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Models Of Protection Against Hiv Siv

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Models of Protection Against HIV SIV

Models of Protection Against HIV SIV Book
Author : Gianfranco Pancino,Guido Silvestri,Keith Fowke
Publisher : Academic Press
Release : 2011-12-02
ISBN : 0123877156
Language : En, Es, Fr & De

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Book Description :

A successful vaccine for the prevention and/or immunotherapy against HIV/AIDS is one of the prominent challenges of the 21st century. To date, all human vaccine trials against this virus/disease have resulted in failure, or at best have shown very low efficacy. The scientific community dealing with HIV/AIDS has unanimously proposed a focus on basic science, with the intention of identifying correlates of protection that can serve as guides in developing and evaluating vaccine preparation. However, Nature seems to have already found several ways of dealing with infections by HIV and related primate lentiviruses, either by resisting infection or, once infected, avoiding immune damage and immunodeficiency. Models of Protection Against HIV/SIV will allow for an in-depth reflection on the perspectives for vaccine and therapy research derived from important recent studies. It will be authored by some of the most well known specialists in the field of HIV resistance/protection: including F. Barré-Sinoussi (2008 Nobel Prize for Medicine winner), B. Walker, S. Rowland-Jones, A. Telenti, M. Lederman and F. Plummer. This book is structured in a unique way, looking at three models of resistance/protection separately and then comparing the models against one another to provide its readership with a detailed examination of the research that is most predominant in the search for a vaccine. This structure presents the information in an easy-to-understand format and gives the book a cross-discipline appeal -- an important reference for those in the scientific community, medical care, public health and academia alike. Provides extensive descriptions and comparisons on the different models of protection agains HIV/AIDS Comprehensive writing and illustrations Contributors are among the most eminent specialists in the field

Models of Protection Against HIV SIV

Models of Protection Against HIV SIV Book
Author : Gianfranco Pancino,Guido Silvestri,Keith Fowke
Publisher : Academic Press
Release : 2011-11-02
ISBN : 0123877164
Language : En, Es, Fr & De

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Book Description :

A successful vaccine for the prevention and/or immunotherapy against HIV/AIDS is one of the prominent challenges of the 21st century. To date, all human vaccine trials against this virus/disease have resulted in failure, or at best have shown very low efficacy. The scientific community dealing with HIV/AIDS has unanimously proposed a focus on basic science, with the intention of identifying correlates of protection that can serve as guides in developing and evaluating vaccine preparation. However, Nature seems to have already found several ways of dealing with infections by HIV and related primate lentiviruses, either by resisting infection or, once infected, avoiding immune damage and immunodeficiency. Models of Protection Against HIV/SIV will allow for an in-depth reflection on the perspectives for vaccine and therapy research derived from important recent studies. It will be authored by some of the most well known specialists in the field of HIV resistance/protection: including F. Barré-Sinoussi (2008 Nobel Prize for Medicine winner), B. Walker, S. Rowland-Jones, A. Telenti, M. Lederman and F. Plummer. This book is structured in a unique way, looking at three models of resistance/protection separately and then comparing the models against one another to provide its readership with a detailed examination of the research that is most predominant in the search for a vaccine. This structure presents the information in an easy-to-understand format and gives the book a cross-discipline appeal -- an important reference for those in the scientific community, medical care, public health and academia alike. Provides extensive descriptions and comparisons on the different models of protection agains HIV/AIDS Comprehensive writing and illustrations Contributors are among the most eminent specialists in the field

Health of HIV Infected People

Health of HIV Infected People Book
Author : Ronald Ross Watson
Publisher : Academic Press
Release : 2015-04-29
ISBN : 0128011416
Language : En, Es, Fr & De

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Book Description :

Health of HIV Infected People: Food, Nutrition and Lifestyle Without Antiretroviral Drugs defines the supportive roles of bioactive foods, exercise, and dietary supplements on the health of HIV infected people who do not have access to resources or those who choose not to utilize antiretroviral drugs. Approaches such as the application of traditional herbs and foods are given careful definition by experts who define the risks and benefits of such practices within this important context. Readers learn how to treat or ameliorate the effects of chronic retroviral disease using readily available, cheap foods, and dietary supplements. Ultimately, this work delivers a current, concise, scientific appraisal of the efficacy of key foods, nutrients, dietary plants, and behavioral changes in preventing and improving the quality of life of HIV infected infants and adults who are not undergoing antiretroviral therapy. Covers the role of nutrients in the prevention and treatment of HIV-induced physiological changes Delivers important coverage on the relationship between HIV infection and infant feeding practice, along with public health policy recommendations in social and cultural context Provides coverage of fitness and exercise regimens, physical activity, and behavioral and lifestyle changes on HIV infected individuals Explores food and treatment of obesity, diabetes, and cardiovascular disease in HIV infected patients, including those without antiretroviral therapeutic treatmen

Adverse Reactions to HIV Vaccines

Adverse Reactions to HIV Vaccines Book
Author : Anonim
Publisher : Office of Technology Assessment
Release : 1995
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Adverse Reactions to HIV Vaccines book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

AIDS Bibliography

AIDS Bibliography Book
Author : Anonim
Publisher : Unknown
Release : 1994-07
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download AIDS Bibliography book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Adverse reactions to HIV vaccines medical ethical and legal issues

Adverse reactions to HIV vaccines   medical  ethical  and legal issues  Book
Author : Anonim
Publisher : DIANE Publishing
Release : 1995
ISBN : 142892003X
Language : En, Es, Fr & De

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Book Description :

AIDS researchers are investigating new vaccines that would prevent infection with HIV and reduce the spread of AIDS. Some have argued that product liability concerns have discouraged investment in HIV vaccine research and development. The purpose of this OTA background paper is to describe the current state of development of HIV vaccines, and to discuss what is known about adverse reactions that may occur. The background paper provides an overview of ethical issues that arise in the conduct of HIV vaccine trials. The report also discusses alternatives to the current product liability system to encourage the development of HIV vaccines and to fairly compensate those who are harmed as a result of adverse reactions to the vaccine. This background paper was prepared in response to a request from the Subcommittee on Health of the House Ways and Means Committee. It is eleventh in OTA's series of studies on HIV-related issues.

Cellular Responses to Aids Virus Infection

Cellular Responses to Aids Virus Infection Book
Author : John Loffredo
Publisher : VDM Publishing
Release : 2008
ISBN : 9783836492867
Language : En, Es, Fr & De

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Book Description :

In 2007, approximately 33 million people were living with HIV/AIDS worldwide, while an estimated 2.5 million new infections occurred and 2.1 million AIDS-related deaths. With >95% of new infections occurring in low and middle income countries with limited access to antiretroviral therapy, the development of a prophylactic HIV vaccine remains one of the world's top public health priorities. Many studies illustrate the important role of CD8+ T lymphocytes, also known as cytotoxic T lymphocytes (CTL), in controlling HIV and simian immunodeficiency virus (SIV) replication. However, the correlates of immune protection remain unknown. The SIV-infected rhesus macaque is the most widely used animal model for studying HIV infection. We enhanced the utility of this model by evaluating the breadth of novel, SIV-specific CTL responses in infected macaques. We then examined the antiviral efficacy of these SIV-specific CTL using a novel viral suppression assay. This information may be important in determining the type of CTL epitopes to be targeted in future HIV vaccines. This research should be especially useful for those studying cellular immune responses against AIDS-virus infection.

Ethical Issues in HIV Vaccine Trials

Ethical Issues in HIV Vaccine Trials Book
Author : T. Kerns
Publisher : Springer
Release : 1996-12-11
ISBN : 0230380018
Language : En, Es, Fr & De

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Book Description :

This book explores some of the complex ethical quandaries entailed by proposed phase III HIV preventive vaccine trials. The book argues that such trials must be initiated as soon as politically and ethically feasible on the one hand, and that no such trials should be undertaken until we can assure full compliance with the Nuremberg Code and the WHO/CIOMS International Ethical Guidelines for Biomedical Research Involving Human Subjects on the other. The tension between these two positions is fully detailed and suggestions offered for how to think about possible resolutions.

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease Book
Author : Sara I. Ruiz,Elizabeth E. Zumbrun,Aysegul Nalca
Publisher : Elsevier Inc. Chapters
Release : 2013-05-29
ISBN : 0128072288
Language : En, Es, Fr & De

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Book Description :

As the threat of exposure to emerging and reemerging viruses within a naive population increases, it is vital that the basic mechanisms of pathogenesis and immune response be thoroughly investigated. By using animal models in this endeavor, the response to viruses can be studied in a more natural context to identify novel drug targets, and assess the efficacy and safety of new products. This is especially true in the advent of the Food and Drug Administration's animal rule. Although no one animal model is able to recapitulate all the aspects of human disease, understanding the current limitations allows for a more targeted experimental design. Important facets to be considered before an animal study are the route of challenge, species of animals, biomarkers of disease, and a humane endpoint. This chapter covers the current animal models for medically important human viruses, and demonstrates where the gaps in knowledge exist.

AIDS Research at EC Level

AIDS Research at EC Level Book
Author : Andre E. Baert
Publisher : IOS Press
Release : 1995
ISBN : 9789051991598
Language : En, Es, Fr & De

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Book Description :

At EC level the fight against AIDS, one of the major health problems and socioeconomic diseases today, is also part of the specific RTD programme in the field of biomedicine and health. About 600 research teams are collaborating within 30 concerted actions networks that are underpinned by centralised facilities. For example, the epidemiology research networks are monitored by the WHO/EC collaborating centre in St. Maurice, France. Common experiments on animal models, antiviral screening, genetic analysis of multiple virus strains and provision of reagents for vaccine development are also centralized facilities in AIDS research carried out under the principles of subsidiarity and Community added value. This publication presents an overview of their ongoing research activities in disease control and prevention, viro-immunological research, clinical research and vaccine development. Covered by Current Contents, Life Sciences (ISI), volume 38, no. 19, May 1995, p. 11-12 'Therefore, for anyone doing AIDS research, this is a must volume to have in order to understand what the European Community is doing in AIDS research. Highly recommended for all medical and academic libraries.' - H. Robert Malinowsky, The University of Illinois, Chicago, USA. AIDS Book Review Journal, no. 27, June 1996

AIDS and Other Manifestations of HIV Infection

AIDS and Other Manifestations of HIV Infection Book
Author : Gary Wormser
Publisher : Elsevier
Release : 2004-02-18
ISBN : 9780080471969
Language : En, Es, Fr & De

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Book Description :

Extensively revised and updated, the new edition of AIDS and Other Manifestations of HIV Infection is an essential reference resource providing a comprehensive overview of the biological properties of this etiologic viral agent, its clinicopathological manifestations, the epidemiology of its infection, and present and future therapeutic options. Expanded section on clinical manifestations includes new chapters on cardiovascular, renal and dermatologic manifestations of HIV infection Additional chapters on molecular diagnostic techniques, the role of host genetic variation in HIV infection and its manifestations, the discovery and development of new HIV medicines, analysis of HIV dynamics using mathematical models, toxicities of antiretroviral therapy, HIV drug susceptibility testing, practical therapeutics and the global impact of HIV and AIDS

Vaccines E Book

Vaccines E Book Book
Author : Stanley A. Plotkin,Walter Orenstein,Paul A. Offit
Publisher : Elsevier Health Sciences
Release : 2012-09-22
ISBN : 1455737984
Language : En, Es, Fr & De

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Book Description :

Apply the latest vaccination knowledge with a reference that Bill Gates calls "an indispensable guide to the enhancement of the well-being of our world." Inside Vaccines, you’ll find comprehensive and current coverage of every aspect of vaccination, from the development of each vaccine to its use in reducing disease. This medical reference book offers the expert information you need to apply the very latest techniques and information in your practice! Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Gain a complete understanding of each disease, including clinical characteristics, microbiology, pathogenesis, diagnosis, and treatment, as well as epidemiology and public health and regulatory issues. Update your knowledge of both existing vaccines and vaccines currently in the research and development stage. Get complete answers on each vaccine, including its stability, immunogenicity, efficacy, duration of immunity, adverse events, indications, contraindications, precautions, administration with other vaccines, and disease-control strategies. Analyze the cost-benefit and cost-effectiveness of different vaccine options. Clearly visualize concepts and objective data through an abundance of tables and figures. Make optimal use of the latest vaccines for pneumococcal disease, rotavirus, human papillomavirus, herpes zoster, meningococcal disease, and much more. Stay at the forefront of new developments with completely updated chapters on malaria and HIV vaccines, a new chapter on vaccine regulations across the world, and many other revisions throughout.

In vivo Models of HIV Disease and Control

In vivo Models of HIV Disease and Control Book
Author : Herman Friedman,Steven Specter,Mauro Bendinelli
Publisher : Springer Science & Business Media
Release : 2007-04-27
ISBN : 0387257411
Language : En, Es, Fr & De

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Book Description :

An AIDS vaccine is still elusive and HIV treatment continues to develop multidrug resistance at alarming rates. Because of the similarities between HIV and immune deficiency infections in a variety of animals, it is only natural that scientists use these animals as models to study pathogenesis, treatment, vaccine development and many other aspects of HIV. Part of the series Infectious Agents and Pathogenesis, this volume reviews the immune deficiency virus in a variety of hosts. Pathogenesis, vaccine and drug development, epidemiology, and the natural history of the monkey, mouse, cat, cow, horse, and other animal viruses are detailed and compared to HIV. Also included are chapters on the history and future of animal models, as well as a chapter on ethical and safety considerations in using animal models for AIDS studies.

Vaccines E Book

Vaccines E Book Book
Author : Stanley A. Plotkin,Walter Orenstein,Paul A. Offit,Kathryn M. Edwards
Publisher : Elsevier Health Sciences
Release : 2017-04-07
ISBN : 0323393012
Language : En, Es, Fr & De

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Book Description :

From the development of each vaccine to its use in reducing disease, Plotkin’s Vaccines, 7th Edition, provides the expert information you need to provide optimal care to your patients. This award-winning text offers a complete understanding of each disease, as well as the latest knowledge of both existing vaccines and those currently in research and development. Described by Bill Gates as "an indispensable guide to the enhancement of the well-being of our world," Plotkin’s Vaccines is a must-have reference for current, authoritative information in this fast-moving field. Includes complete information for each disease, including clinical characteristics, microbiology, pathogenesis, diagnosis, and treatment, epidemiology, and public health and regulatory issues – plus complete information for each vaccine, including its stability, immunogenicity, efficacy, duration of immunity, adverse events, indications, contraindications, precautions, administration with other vaccines, and disease-control strategies. Analyzes the cost-benefit and cost-effectiveness of different vaccine options. Helps you clearly visualize concepts and objective data through an abundance of tables and figures. Covers the new oral cholera and zoster vaccines, as well as newly licensed meningococcal group B vaccines and a newly licensed dengue vaccine. Brings you up to date on successful human trials of Ebola vaccines, an enterovirus 71 vaccine licensed in China, and new recommendations and changes to polio vaccines. Features a new chapter on maternal immunization.

Natural Hosts of SIV

Natural Hosts of SIV Book
Author : Aftab A. Ansari,Guido Silvestri
Publisher : Newnes
Release : 2014-07-04
ISBN : 0124051677
Language : En, Es, Fr & De

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Book Description :

Natural Hosts of SIV: Implications in AIDS thoroughly reviews the possible mechanisms by which African nonhuman primate natural hosts of lentiviruses remain essentially disease-free while other hosts exhibit disease and death. The book ultimately indicates directions for further research and potential translations of this compelling phenomenon into novel approaches to treat and prevent HIV. When Asian non-human primate non-natural hosts are experimentally infected with viruses isolated from African species, disease and death normally results. Meanwhile, these African nonhuman primate natural hosts maintain similar levels of plasma and cellular viremia and exhibit compellingly different, essentially disease-free, states. This work attempts to answer the question of how the natural host remains disease resistant. Summarizes the past 30 years of research in this field and describes the latest developments in AIDS research using nonhuman primate animal models Provides insights into how this large body of scientific work can be translated into novel approaches to treat and prevent HIV Highlights the areas that merit future pursuit, focusing on potential applications for the treatment and prevention of HIV infection

The Laboratory Primate

The Laboratory Primate Book
Author : Anonim
Publisher : Elsevier
Release : 2005-09-19
ISBN : 9780080454160
Language : En, Es, Fr & De

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Book Description :

A volume in the Handbook of Experimental Animals series, The Laboratory Primate details the past and present use of primates in biomedical research, and the husbandry, nutritional requirements, behaviour, and breeding of each of the commonly used species. Practical information on regulatory requirements, not available in other texts, is covered. Sections on experimental models cover the major areas of biomedical research, including AIDS, cancer, neurobiology and gene therapy. Assisted reproductive technology, tissue typing, and minimum group sizes for infectious disease/vaccine studies are also included. Two-color, user-friendly format, with copious illustrations and color plates Includes detailed, well-illustrated sections on gross & microscopic anatomy, common diseases, and special procedures, including surgical techniques

Handbook of Laboratory Animal Science

Handbook of Laboratory Animal Science Book
Author : Jann Hau,Per Svendsen,Steven J. Schapiro
Publisher : CRC Press
Release : 1994-06-02
ISBN : 9780849343902
Language : En, Es, Fr & De

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Book Description :

This two-volume set presents a comprehensive description of laboratory animal genetics, diseases, health monitoring, nutrition, and the environmental impact on animal testing. It considers the ethics of animal experimentation through a complete review of European and North American legislation on the topic. It discusses alternatives to animal experiments, including the use of isolated organs, cell cultures, and computer simulations. The book also examines general methods, including experimental design and statistical evaluation, non-surgical and surgical techniques, anesthesia, and post-mortem examinations. Reviews of animal models for studying diseases of different organ systems, infectious diseases, cancer, and toxicology are featured as well.

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease Book
Author : P. Michael Conn
Publisher : Academic Press
Release : 2017-06-20
ISBN : 0128096993
Language : En, Es, Fr & De

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Book Description :

Animal Models for the Study of Human Disease, Second Edition, provides needed information on model sharing, animal alternatives, animal ethics and access to databanks of models, bringing together common descriptions of models for busy researchers across biomedical and biological sciences. Offering easily searchable advantages and disadvantages for each animal model and organized by disease topics, this resource aids researchers in finding the best animal model for research in human disease. Organized by disease orientation for ease of searchability Provides information on locating resources, animal alternatives, and animal ethics Covers a broad range of animal models used in research for human disease Contributed by leading experts across the globe Expanded coverage of diabetes and neurological diseases

Cumulated Index Medicus

Cumulated Index Medicus Book
Author : Anonim
Publisher : Unknown
Release : 1999
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Cumulated Index Medicus book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

AIDS Research and Human Retroviruses

AIDS Research and Human Retroviruses Book
Author : Anonim
Publisher : Unknown
Release : 1998
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download AIDS Research and Human Retroviruses book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.