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Models of Protection Against HIV SIV

Models of Protection Against HIV SIV Book
Author : Gianfranco Pancino,Guido Silvestri,Keith R. Fowke
Publisher : Academic Press
Release : 2012-01
ISBN : 0123877156
Language : En, Es, Fr & De

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Book Description :

A successful vaccine for the prevention and/or immunotherapy against HIV/AIDS is one of the prominent challenges of the 21st century. To date, all human vaccine trials against this virus/disease have resulted in failure, or at best have shown very low efficacy. The scientific community dealing with HIV/AIDS has unanimously proposed a focus on basic science, with the intention of identifying correlates of protection that can serve as guides in developing and evaluating vaccine preparation. However, Nature seems to have already found several ways of dealing with infections by HIV and related primate lentiviruses, either by resisting infection or, once infected, avoiding immune damage and immunodeficiency. Models of Protection Against HIV/SIV will allow for an in-depth reflection on the perspectives for vaccine and therapy research derived from important recent studies. It will be authored by some of the most well known specialists in the field of HIV resistance/protection: including F. Barré-Sinoussi (2008 Nobel Prize for Medicine winner), B. Walker, S. Rowland-Jones, A. Telenti, M. Lederman and F. Plummer. This book is structured in a unique way, looking at three models of resistance/protection separately and then comparing the models against one another to provide its readership with a detailed examination of the research that is most predominant in the search for a vaccine. This structure presents the information in an easy-to-understand format and gives the book a cross-discipline appeal -- an important reference for those in the scientific community, medical care, public health and academia alike. Provides extensive descriptions and comparisons on the different models of protection agains HIV/AIDS Comprehensive writing and illustrations Contributors are among the most eminent specialists in the field

Models of Protection Against HIV SIV

Models of Protection Against HIV SIV Book
Author : Gianfranco Pancino,Guido Silvestri,Keith Fowke
Publisher : Academic Press
Release : 2011-11-02
ISBN : 0123877164
Language : En, Es, Fr & De

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Book Description :

A successful vaccine for the prevention and/or immunotherapy against HIV/AIDS is one of the prominent challenges of the 21st century. To date, all human vaccine trials against this virus/disease have resulted in failure, or at best have shown very low efficacy. The scientific community dealing with HIV/AIDS has unanimously proposed a focus on basic science, with the intention of identifying correlates of protection that can serve as guides in developing and evaluating vaccine preparation. However, Nature seems to have already found several ways of dealing with infections by HIV and related primate lentiviruses, either by resisting infection or, once infected, avoiding immune damage and immunodeficiency. Models of Protection Against HIV/SIV will allow for an in-depth reflection on the perspectives for vaccine and therapy research derived from important recent studies. It will be authored by some of the most well known specialists in the field of HIV resistance/protection: including F. Barré-Sinoussi (2008 Nobel Prize for Medicine winner), B. Walker, S. Rowland-Jones, A. Telenti, M. Lederman and F. Plummer. This book is structured in a unique way, looking at three models of resistance/protection separately and then comparing the models against one another to provide its readership with a detailed examination of the research that is most predominant in the search for a vaccine. This structure presents the information in an easy-to-understand format and gives the book a cross-discipline appeal -- an important reference for those in the scientific community, medical care, public health and academia alike. Provides extensive descriptions and comparisons on the different models of protection agains HIV/AIDS Comprehensive writing and illustrations Contributors are among the most eminent specialists in the field

11th Annual Symposium on Nonhuman Primate Models for AIDS

11th Annual Symposium on Nonhuman Primate Models for AIDS Book
Author : Anonim
Publisher : Unknown
Release : 1993
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download 11th Annual Symposium on Nonhuman Primate Models for AIDS book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Science Challenging AIDS

Science Challenging AIDS Book
Author : Gaetano Giraldo,Giovanni B. Rossi
Publisher : S Karger Ag
Release : 1992
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Science Challenging AIDS book written by Gaetano Giraldo,Giovanni B. Rossi, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Cellular Immunity Among HIV Exposed Uninfected Individuals

Cellular Immunity Among HIV Exposed  Uninfected Individuals Book
Author : George Makedonas
Publisher : Unknown
Release : 2005
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

"Two models of HIV infection have been studied extensively with the goal of identifying immune correlate(s) of protection against HIV: (1) the simian immunodeficiency virus (SIV) infection of rhesus macaque monkeys and (2) individuals with repeated exposure to HIV who remain uninfected by the virus (EUs). Both paradigms suggest that T cell-mediated immunity plays an important role in controlling HIV replication. Evidence from the SIV/macaque system, however, predicts that HIV vaccines aimed at eliciting T cell responses will fail to induce sterilizing immunity against HIV. The aim of the work presented in this thesis was to correlate HIV-specific T cell immunity in EUs with protection from HIV infection. The study cohort was comprised of (a) men who have unprotected sexual intercourse with HIV-infected men (MSM), (b) intravenous drug users (IVDU) who share syringes with HIV-infected peers, and (c) heterosexual partners of HIV-infected subjects. EUs were shown to exhibit HIV-specific IFN-gamma secretion, IL-2 production, and T cell proliferation, whereas low-risk negative controls did not. Furthermore, HIV-specific IFN-gamma secretion and T cell proliferation were not observed among a population of EUs who seroconverted soon after the tested time point. HIV-specific IL-2 secretion and T cell proliferation were shown to be correlated in our cohort of EUs. These effector functions are considered hallmark properties of central memory T cells (TCM), the subset of memory T cells that has been shown to mediate sterilizing immunity in mouse models of viral infection. The presence of TCM in EUs implies the development of immunity against HIV that is either fully protective or partially so, by increasing the threshold for HIV infection. Since these HIV-specific effector functions were absent in EUs who eventually seroconverted, it can be inferred that EUs in our cohort develop HIV-specific T cell immunity that mediates protection from HIV infection. Thus, our contribution to the EU paradigm is that sterilizing immunity is an attainable goal of prospective HIV vaccines." --

Adverse reactions to HIV vaccines medical ethical and legal issues

Adverse reactions to HIV vaccines   medical  ethical  and legal issues  Book
Author : Anonim
Publisher : DIANE Publishing
Release : 1995
ISBN : 142892003X
Language : En, Es, Fr & De

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Book Description :

AIDS researchers are investigating new vaccines that would prevent infection with HIV and reduce the spread of AIDS. Some have argued that product liability concerns have discouraged investment in HIV vaccine research and development. The purpose of this OTA background paper is to describe the current state of development of HIV vaccines, and to discuss what is known about adverse reactions that may occur. The background paper provides an overview of ethical issues that arise in the conduct of HIV vaccine trials. The report also discusses alternatives to the current product liability system to encourage the development of HIV vaccines and to fairly compensate those who are harmed as a result of adverse reactions to the vaccine. This background paper was prepared in response to a request from the Subcommittee on Health of the House Ways and Means Committee. It is eleventh in OTA's series of studies on HIV-related issues.

AIDS Bibliography

AIDS Bibliography Book
Author : Anonim
Publisher : Unknown
Release : 1994
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download AIDS Bibliography book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The AIDS Knowledge Base

The AIDS Knowledge Base Book
Author : Philip T. Cohen,Merle A. Sande,Paul Volberding
Publisher : Little Brown GBR
Release : 1994
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

(1E 1990; *Select List Medical) Covers epidemiology & transmission/testing for HIV/clinical manifestations/etc.

Analysis of Restriction of HIV 1 Replication in Macaque Cells

Analysis of Restriction of HIV 1 Replication in Macaque Cells Book
Author : Sunee Himathongkham
Publisher : Unknown
Release : 1996
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Analysis of Restriction of HIV 1 Replication in Macaque Cells book written by Sunee Himathongkham, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Mobilizing Against AIDS

Mobilizing Against AIDS Book
Author : Eve K. Nichols
Publisher : Unknown
Release : 1989
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This book presents a examination of data on the spread of AIDS and attempts to prevent that growth; it was drawn from a meeting of the Institute of Medicine, National Academy of Sciences.

AIDS Research and Human Retroviruses

AIDS Research and Human Retroviruses Book
Author : Anonim
Publisher : Unknown
Release : 1998
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download AIDS Research and Human Retroviruses book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Human Retroviruses and AIDS

Human Retroviruses and AIDS Book
Author : Anonim
Publisher : Unknown
Release : 1999
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Human Retroviruses and AIDS book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

AIDS Sourcebook

AIDS Sourcebook Book
Author : Karen Bellenir,Peter D. Dresser
Publisher : Omnigraphics Incorporated
Release : 1995
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Basic Information about AIDS and HIV Infections, Featuring Historical and Statistical Data, Current Research, Prevention, and Other Special Topics of Interest for Persons Living with AIDS, along with Source Listings for Further Assistance

Vaccines E Book

Vaccines E Book Book
Author : Stanley A. Plotkin,Walter Orenstein,Paul A. Offit
Publisher : Elsevier Health Sciences
Release : 2012-09-22
ISBN : 1455737984
Language : En, Es, Fr & De

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Book Description :

Apply the latest vaccination knowledge with a reference that Bill Gates calls "an indispensable guide to the enhancement of the well-being of our world." Inside Vaccines, you’ll find comprehensive and current coverage of every aspect of vaccination, from the development of each vaccine to its use in reducing disease. This medical reference book offers the expert information you need to apply the very latest techniques and information in your practice! Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Gain a complete understanding of each disease, including clinical characteristics, microbiology, pathogenesis, diagnosis, and treatment, as well as epidemiology and public health and regulatory issues. Update your knowledge of both existing vaccines and vaccines currently in the research and development stage. Get complete answers on each vaccine, including its stability, immunogenicity, efficacy, duration of immunity, adverse events, indications, contraindications, precautions, administration with other vaccines, and disease-control strategies. Analyze the cost-benefit and cost-effectiveness of different vaccine options. Clearly visualize concepts and objective data through an abundance of tables and figures. Make optimal use of the latest vaccines for pneumococcal disease, rotavirus, human papillomavirus, herpes zoster, meningococcal disease, and much more. Stay at the forefront of new developments with completely updated chapters on malaria and HIV vaccines, a new chapter on vaccine regulations across the world, and many other revisions throughout.

Development of Humanized Mouse Models for Infectious Diseases and Cancer

Development of Humanized Mouse Models for Infectious Diseases and Cancer Book
Author : Moriya Tsuji,Ramesh Akkina
Publisher : Frontiers Media SA
Release : 2020-02-19
ISBN : 2889634817
Language : En, Es, Fr & De

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Book Description :

Download Development of Humanized Mouse Models for Infectious Diseases and Cancer book written by Moriya Tsuji,Ramesh Akkina, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Research Resources Reporter

Research Resources Reporter Book
Author : Anonim
Publisher : Unknown
Release : 1989
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Research Resources Reporter book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Partial Protection of SIV infected Rhesus Monkeys Against Superinfection with a Heterologous SIV Isolate

Partial Protection of SIV infected Rhesus Monkeys Against Superinfection with a Heterologous SIV Isolate Book
Author : Anonim
Publisher : Unknown
Release : 2009
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Although there is increasing evidence that individuals already infected with human immunodeficiency virus type 1 (HIV-1) can be infected with a heterologous strain of the virus, the extent of protection against superinfection conferred by the first infection and the biologic consequences of superinfection are not well understood. We explored these questions in the simian immunodeficiency virus (SIV)/rhesus monkey model of HIV-1/AIDS. We infected cohorts of rhesus monkeys with either SIVmac251 or SIVsmE660 and then exposed animals to the reciprocal virus through intrarectal inoculations. Employing a quantitative real-time PCR assay, we determined the replication kinetics of the two strains of virus for 20 weeks. We found that primary infection with a replication-competent virus did not protect against acquisition of infection by a heterologous virus but did confer relative control of the superinfecting virus. In animals that became superinfected, there was a reduction in peak replication and rapid control of the second virus. The relative susceptibility to superinfection was not correlated with CD4(+) T-cell count, CD4(+) memory T-cell subsets, cytokine production by virus-specific CD8(+) or CD4(+) cells, or neutralizing antibodies at the time of exposure to the second virus. Although there were transient increases in viral loads of the primary virus and a modest decline in CD4(+) T-cell counts after superinfection, there was no evidence of disease acceleration. These findings indicate that an immunodeficiency virus infection confers partial protection against a second immunodeficiency virus infection, but this protection may be mediated by mechanisms other than classical adaptive immune responses.

The Molecular Biology of HIV AIDS

The Molecular Biology of HIV AIDS Book
Author : A. M. L. Lever
Publisher : John Wiley & Son Limited
Release : 1996-05-07
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This study, based on both clinical and molecular trials, outlines the principles of the molecular biology of HIV and AIDS. Topics such as the origins of the virus, viral interactions with the immune system, antiviral intervention and vaccine prospects are covered.

HIV Immunology and HIV SIV Vaccine Databases 2003

HIV Immunology and HIV SIV Vaccine Databases 2003 Book
Author : Anonim
Publisher : DIANE Publishing
Release : 2021-07-25
ISBN : 1428918124
Language : En, Es, Fr & De

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Book Description :

Download HIV Immunology and HIV SIV Vaccine Databases 2003 book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.