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Modelling Methodology For Physiology And Medicine

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Modelling Methodology for Physiology and Medicine

Modelling Methodology for Physiology and Medicine Book
Author : Ewart Carson,Claudio Cobelli
Publisher : Elsevier Science Limited
Release : 2013-12-01
ISBN : 9780124115576
Language : En, Es, Fr & De

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Book Description :

Modelling Methodology for Physiology and Medicine, Second Edition, offers a unique approach and an unprecedented range of coverage of the state-of-the-art, advanced modeling methodology that is widely applicable to physiology and medicine. The second edition, which is completely updated and expanded, opens with a clear and integrated treatment of advanced methodology for developing mathematical models of physiology and medical systems. Readers are then shown how to apply this methodology beneficially to real-world problems in physiology and medicine, such as circulation and respiration. The focus of Modelling Methodology for Physiology and Medicine, Second Edition, is the methodology that underpins good modeling practice. It builds upon the idea of an integrated methodology for the development and testing of mathematical models. It covers many specific areas of methodology in which important advances have taken place over recent years and illustrates the application of good methodological practice in key areas of physiology and medicine. It builds on work that the editors have carried out over the past 30 years, working in cooperation with leading practitioners in the field. Builds upon and enhances the reader's existing knowledge of modeling methodology and practice Editors are internationally renowned leaders in their respective fields Provides an understanding of modeling methodologies that can address real problems in physiology and medicine and achieve results that are beneficial either in advancing research or in providing solutions to clinical problems

Modelling Methodology for Physiology and Medicine

Modelling Methodology for Physiology and Medicine Book
Author : Ewart Carson,Claudio Cobelli
Publisher : Newnes
Release : 2013-12-05
ISBN : 0124095259
Language : En, Es, Fr & De

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Book Description :

Modelling Methodology for Physiology and Medicine, Second Edition, offers a unique approach and an unprecedented range of coverage of the state-of-the-art, advanced modeling methodology that is widely applicable to physiology and medicine. The second edition, which is completely updated and expanded, opens with a clear and integrated treatment of advanced methodology for developing mathematical models of physiology and medical systems. Readers are then shown how to apply this methodology beneficially to real-world problems in physiology and medicine, such as circulation and respiration. The focus of Modelling Methodology for Physiology and Medicine, Second Edition, is the methodology that underpins good modeling practice. It builds upon the idea of an integrated methodology for the development and testing of mathematical models. It covers many specific areas of methodology in which important advances have taken place over recent years and illustrates the application of good methodological practice in key areas of physiology and medicine. It builds on work that the editors have carried out over the past 30 years, working in cooperation with leading practitioners in the field. Builds upon and enhances the reader's existing knowledge of modeling methodology and practice Editors are internationally renowned leaders in their respective fields Provides an understanding of modeling methodologies that can address real problems in physiology and medicine and achieve results that are beneficial either in advancing research or in providing solutions to clinical problems

Introduction to Modeling in Physiology and Medicine

Introduction to Modeling in Physiology and Medicine Book
Author : Claudio Cobelli,Ewart Carson
Publisher : Academic Press
Release : 2019-08-01
ISBN : 0128158050
Language : En, Es, Fr & De

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Book Description :

Introduction to Modeling in Physiology and Medicine, Second Edition, develops a clear understanding of the fundamental principles of good modeling methodology. Sections show how to create valid mathematical models that are fit for a range of purposes. These models are supported by detailed explanation, extensive case studies, examples and applications. This updated edition includes clearer guidance on the mathematical prerequisites needed to achieve the maximum benefit from the material, a greater detail regarding basic approaches to modeling, and discussions on non-linear and stochastic modeling. The range of case study material has been substantially extended, with examples drawn from recent research experience. Key examples include a cellular model of insulin secretion and its extension to the whole-body level, a model of insulin action during a meal/oral glucose tolerance test, a large-scale simulation model of type 1 diabetes and its use in in silico clinical trials and drug trials. Covers the underlying principles of good quantitative modeling methodology, with applied biomedical engineering and bioscience examples to ensure relevance to students, current research and clinical practice Includes modeling data, modeling systems, linear and non-linear systems, model identification, parametric and non-parametric models, and model validation Presents clear, step-by-step working plus examples and extensive case studies that relate concepts to real world applications Provides end-of-chapter exercises and assignments to reinforce learning

Modeling Methodology for Physiology and Medicine

Modeling Methodology for Physiology and Medicine Book
Author : Ewart Carson,Claudio Cobelli
Publisher : Elsevier
Release : 2017-11-13
ISBN : 9780128102930
Language : En, Es, Fr & De

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Book Description :

"Modelling Methodology for Physiology and Medicine, Second Edition, "offers a unique approach and an unprecedented range of coverage of the state-of-the-art, advanced modeling methodology that is widely applicable to physiology and medicine. The second edition, which is completely updated and expanded, opens with a clear and integrated treatment of advanced methodology for developing mathematical models of physiology and medical systems. Readers are then shown how to apply this methodology beneficially to real-world problems in physiology and medicine, such as circulation and respiration. The focus of "Modelling Methodology for Physiology and Medicine, Second Edition, "is the methodology that underpins good modeling practice. It builds upon the idea of an integrated methodology for the development and testing of mathematical models. It covers many specific areas of methodology in which important advances have taken place over recent years and illustrates the application of good methodological practice in key areas of physiology and medicine. It builds on work that the editors have carried out over the past 30 years, working in cooperation with leading practitioners in the field. Builds upon and enhances the reader's existing knowledge of modeling methodology and practiceEditors are internationally renowned leaders in their respective fieldsProvides an understanding of modeling methodologies that can address real problems in physiology and medicine and achieve results that are beneficial either in advancing research or in providing solutions to clinical problems

Introduction to Modeling in Physiology and Medicine

Introduction to Modeling in Physiology and Medicine Book
Author : Claudio Cobelli,Ewart Carson
Publisher : Elsevier
Release : 2008-02-06
ISBN : 9780080559988
Language : En, Es, Fr & De

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Book Description :

This unified modeling textbook for students of biomedical engineering provides a complete course text on the foundations, theory and practice of modeling and simulation in physiology and medicine. It is dedicated to the needs of biomedical engineering and clinical students, supported by applied BME applications and examples. Developed for biomedical engineering and related courses: speaks to BME students at a level and in a language appropriate to their needs, with an interdisciplinary clinical/engineering approach, quantitative basis, and many applied examples to enhance learning Delivers a quantitative approach to modeling and also covers simulation: the perfect foundation text for studies across BME and medicine Extensive case studies and engineering applications from BME, plus end-of-chapter exercises

Advanced Methods of Physiological System Modeling

Advanced Methods of Physiological System Modeling Book
Author : V.Z. Marmarelis
Publisher : Springer
Release : 2013-04-29
ISBN : 9781475790269
Language : En, Es, Fr & De

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Book Description :

This volume is the third in a series entitled" Advanced Methods of Physiological System Modeling" and the fifth in a series of research volumes published by Plenum under the sponsorship of the Biomedical Simulations Resource (BMSR) at the Uni versity of Southern California in the context of dissemination activities supported by the Biomedical Research Technology Program of the National Center for Research Resources at the National Institutes of Health under Grant No. P41 RR-OI861. These volumes are edited by BMSR principal scientists and report on recent research de velopments in the area of physiological systems modeling, as well as on advanced methods for analysis of physiological signals and data. As in the previous two volumes of this series, the work reported herein is con cerned with the development of advanced modeling methodologies and their novel application to problems of biomedical interest, with emphasis on nonlinear aspects of physiological function. The term "advanced methodologies" is used to indicate that the scope of this work extends beyond the ordinary type of analysis, which is confined traditionally to the linear domain. As the importance of nonlinearities in understanding the complex mechanisms of physiological function is increasingly recognized, the need for effective and practical modeling methodologies that address the issue of nonlinear dynamics in life sciences becomes more and more pressing.

Physiological Control Systems

Physiological Control Systems Book
Author : Michael C. K. Khoo
Publisher : John Wiley & Sons
Release : 2018-06-06
ISBN : 1119055334
Language : En, Es, Fr & De

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Book Description :

A guide to common control principles and how they are used to characterize a variety of physiological mechanisms The second edition of Physiological Control Systems offers an updated and comprehensive resource that reviews the fundamental concepts of classical control theory and how engineering methodology can be applied to obtain a quantitative understanding of physiological systems. The revised text also contains more advanced topics that feature applications to physiology of nonlinear dynamics, parameter estimation methods, and adaptive estimation and control. The author—a noted expert in the field—includes a wealth of worked examples that illustrate key concepts and methodology and offers in-depth analyses of selected physiological control models that highlight the topics presented. The author discusses the most noteworthy developments in system identification, optimal control, and nonlinear dynamical analysis and targets recent bioengineering advances. Designed to be a practical resource, the text includes guided experiments with simulation models (using Simulink/Matlab). Physiological Control Systems focuses on common control principles that can be used to characterize a broad variety of physiological mechanisms. This revised resource: Offers new sections that explore identification of nonlinear and time-varying systems, and provide the background for understanding the link between continuous-time and discrete-time dynamic models Presents helpful, hands-on experimentation with computer simulation models Contains fully updated problems and exercises at the end of each chapter Written for biomedical engineering students and biomedical scientists, Physiological Control Systems, offers an updated edition of this key resource for understanding classical control theory and its application to physiological systems. It also contains contemporary topics and methodologies that shape bioengineering research today.

Nonlinear Dynamic Modeling of Physiological Systems

Nonlinear Dynamic Modeling of Physiological Systems Book
Author : Professor Vasilis Z. Marmarelis
Publisher : John Wiley & Sons
Release : 2004-09-03
ISBN : 9780471469605
Language : En, Es, Fr & De

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Book Description :

The study of nonlinearities in physiology has been hindered by the lack of effective ways to obtain nonlinear dynamic models from stimulus-response data in a practical context. A considerable body of knowledge has accumulated over the last thirty years in this area of research. This book summarizes that progress, and details the most recent methodologies that offer practical solutions to this daunting problem. Implementation and application are discussed, and examples are provided using both synthetic and actual experimental data. This essential study of nonlinearities in physiology apprises researchers and students of the latest findings and techniques in the field.

Biomedical EPR Part A Free Radicals Metals Medicine and Physiology Part B Methodology Instrumentation and Dynamics

Biomedical EPR  Part A  Free Radicals  Metals  Medicine  and Physiology  Part B  Methodology  Instrumentation  and Dynamics Book
Author : Sandra S. Eaton,Gareth R. Eaton,Lawrence Berliner
Publisher : Springer
Release : 2008-05-05
ISBN : 9780387231273
Language : En, Es, Fr & De

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Book Description :

Biomedical EPR – Part A focuses on applications of EPR spectroscopy in the areas of free radicals, metals, medicine, and physiology. The book celebrates the 70th birthday of Prof. James S. Hyde, Medical College of Wisconsin, and his contributions to this field. Chapters are written to provide introductory material for new-comers to the field which lead into up-to-date reviews that provide perspective on the wide range of questions that can be addressed by EPR. Key Features: -Free Radicals in Medicine -Radicals in vivo and in Model Systems, and their Study by Spin Trapping -In vivo EPR, including Oximetry and Imaging -Time Domain EPR at Radio Frequencies -EPR of Copper Complexes: Motion and Frequency Dependence -Time Domain EPR and Electron Spin Echo Envelope Modulation. Biomedical EPR – Part B focuses on applications of EPR techniques and instrumentation, with applications to dynamics. The book celebrates the 70th birthday of Prof. James S. Hyde, Medical College of Wisconsin, and his contributions to this field. Chapters are written to provide introductory material for new-comers to the field that lead into up-to-date reviews that provide perspective on the wide range of questions that can be addressed by EPR. Key Features: -EPR Techniques including Saturation Recovery, ENDOR, ELDOR, and Saturation Transfer -Instrumentation Innovations including Loop Gap Resonators, Rapid Mixing, and Time Locked Sub-Sampling -Motion in Biological Membranes -Applications to Structure Determination in Proteins -Discussion of Trends in EPR Technology and Prognosis for the Future.

Modeling of Physiological Flows

Modeling of Physiological Flows Book
Author : Davide Ambrosi,Alfio Quarteroni,Gianluigi Rozza
Publisher : Springer Science & Business Media
Release : 2012-10-31
ISBN : 8847019354
Language : En, Es, Fr & De

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Book Description :

This book offers a mathematical update of the state of the art of the research in the field of mathematical and numerical models of the circulatory system. It is structured into different chapters, written by outstanding experts in the field. Many fundamental issues are considered, such as: the mathematical representation of vascular geometries extracted from medical images, modelling blood rheology and the complex multilayer structure of the vascular tissue, and its possible pathologies, the mechanical and chemical interaction between blood and vascular walls, and the different scales coupling local and systemic dynamics. All of these topics introduce challenging mathematical and numerical problems, demanding for advanced analysis and efficient simulation techniques, and pay constant attention to applications of relevant clinical interest. This book is addressed to graduate students and researchers in the field of bioengineering, applied mathematics and medicine, wishing to engage themselves in the fascinating task of modeling the cardiovascular system or, more broadly, physiological flows.

Physiology for Engineers

Physiology for Engineers Book
Author : Michael Chappell,Stephen Payne
Publisher : Springer
Release : 2015-11-27
ISBN : 3319261975
Language : En, Es, Fr & De

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Book Description :

This book provides an introduction to qualitative and quantitative aspects of human physiology. It looks at biological and physiological processes and phenomena, including a selection of mathematical models, showing how physiological problems can be mathematically formulated and studied. It also illustrates how a wide range of engineering and physics topics, including electronics, fluid dynamics, solid mechanics and control theory can be used to describe and understand physiological processes and systems. Throughout the text there are introductions to measuring and quantifying physiological processes using both signal and imaging technologies. Physiology for Engineers describes the basic structure and models of cellular systems, the structure and function of the cardiovascular system, the electrical and mechanical activity of the heart and provides an overview of the structure and function of the respiratory and nervous systems. It also includes an introduction to the basic concepts and applications of reaction kinetics, pharmacokinetic modelling and tracer kinetics. It is of interest to final year biomedical engineering undergraduates and graduate students alike, as well as to practising engineers new to the fields of bioengineering or medical physics.

Dynamic Modeling in the Health Sciences

Dynamic Modeling in the Health Sciences Book
Author : James L. Hargrove
Publisher : Springer Science & Business Media
Release : 1998-06-02
ISBN : 9780387949963
Language : En, Es, Fr & De

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Book Description :

The study of complex physiological and metabolic aspects of health can be powerfully enhanced by the use of computer simulation. This book and CD-ROM integrates the use of STELLA' as a tool in understanding health, nutrition and physiology through simulation modeling. Key subjects are discussed, including the theory of metabolic control, weight regulation, bone metabolism, cholesterol dynamics, and gene expression. 122 illus.

Signals and Systems in Biomedical Engineering Physiological Systems Modeling and Signal Processing

Signals and Systems in Biomedical Engineering  Physiological Systems Modeling and Signal Processing Book
Author : Suresh R. Devasahayam
Publisher : Springer
Release : 2019-03-29
ISBN : 9811335311
Language : En, Es, Fr & De

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Book Description :

Physiology is a set of processes that maintain homeostasis, and physiological measurement is a means of observing these processes. Systems theory and signal processing offer formal tools for the study of processes and measured quantities. This book shows that systems modeling can be used to develop simulations of physiological systems, which use formal relations between the underlying processes and the observed measurements. The inverse of such relations suggest signal processing tools that can be applied to interpret experimental data. Both signal processing and systems modeling are invaluable in the study of human physiology. Discussing signal processing techniques ranging from filtering and spectrum analysis to wavelet analysis, the book uses graphs and analogies to supplement the mathematics and make the book more accessible to physiologists and more interesting to engineers. Physiological systems modeling helps in both gaining insight and generating methods of analysis. This book shows how numerical computation with graphical display, haptics and multimedia can be used to simulate physiological systems. In this third edition the simulations are more closely related to clinical examination and experimental physiology than in previous editions. Detailed models of nerve and muscle at the cellular and systemic levels, and simplified models of cardiovascular blood flow provide examples for the mathematical methods and computer simulations. Several of the models are sufficiently sophisticated to be of value in understanding real world issues like neuromuscular disease. The book features expanded problem sets and a link to extra downloadable material containing simulation programs that are solutions to the theory developed in the text.

Control Theory in Biomedical Engineering

Control Theory in Biomedical Engineering Book
Author : Olfa Boubaker
Publisher : Academic Press
Release : 2020-06-30
ISBN : 0128226218
Language : En, Es, Fr & De

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Book Description :

Control Theory in Biomedical Engineering: Applications in Physiology and Medical Robotics highlights the importance of control theory and feedback control in our lives and explains how this theory is central to future medical developments. Control theory is fundamental for understanding feedback paths in physiological systems (endocrine system, immune system, neurological system) and a concept for building artificial organs. The book is suitable for graduate students and researchers in the control engineering and biomedical engineering fields, and medical students and practitioners seeking to enhance their understanding of physiological processes, medical robotics (legs, hands, knees), and controlling artificial devices (pacemakers, insulin injection devices). Control theory profoundly impacts the everyday lives of a large part of the human population including the disabled and the elderly who use assistive and rehabilitation robots for improving the quality of their lives and increasing their independence. Gives an overview of state-of-the-art control theory in physiology, emphasizing the importance of this theory in the medical field through concrete examples, e.g., endocrine, immune, and neurological systems Takes a comprehensive look at advances in medical robotics and rehabilitation devices and presents case studies focusing on their feedback control Presents the significance of control theory in the pervasiveness of medical robots in surgery, exploration, diagnosis, therapy, and rehabilitation

Computational Hemodynamics Theory Modelling and Applications

Computational Hemodynamics     Theory  Modelling and Applications Book
Author : Jiyuan Tu,Kiao Inthavong,Kelvin Kian Loong Wong
Publisher : Springer
Release : 2015-02-24
ISBN : 9401795940
Language : En, Es, Fr & De

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Book Description :

This book discusses geometric and mathematical models that can be used to study fluid and structural mechanics in the cardiovascular system. Where traditional research methodologies in the human cardiovascular system are challenging due to its invasive nature, several recent advances in medical imaging and computational fluid and solid mechanics modelling now provide new and exciting research opportunities. This emerging field of study is multi-disciplinary, involving numerical methods, computational science, fluid and structural mechanics, and biomedical engineering. Certainly any new student or researcher in this field may feel overwhelmed by the wide range of disciplines that need to be understood. This unique book is one of the first to bring together knowledge from multiple disciplines, providing a starting point to each of the individual disciplines involved, attempting to ease the steep learning curve. This book presents elementary knowledge on the physiology of the cardiovascular system; basic knowledge and techniques on reconstructing geometric models from medical imaging; mathematics that describe fluid and structural mechanics, and corresponding numerical/computational methods to solve its equations and problems. Many practical examples and case studies are presented to reinforce best practice guidelines for setting high quality computational models and simulations. These examples contain a large number of images for visualization, to explain cardiovascular physiological functions and disease. The reader is then exposed to some of the latest research activities through a summary of breakthrough research models, findings, and techniques. The book’s approach is aimed at students and researchers entering this field from engineering, applied mathematics, biotechnology or medicine, wishing to engage in this emerging and exciting field of computational hemodynamics modelling.

Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society

Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society Book
Author : IEEE Engineering in Medicine and Biology Society. Annual Conference
Publisher : Unknown
Release : 1989
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society book written by IEEE Engineering in Medicine and Biology Society. Annual Conference, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Advanced Methods of Biomedical Signal Processing

Advanced Methods of Biomedical Signal Processing Book
Author : Sergio Cerutti,Carlo Marchesi
Publisher : John Wiley & Sons
Release : 2011-06-09
ISBN : 9781118007730
Language : En, Es, Fr & De

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Book Description :

This book grew out of the IEEE-EMBS Summer Schools on Biomedical Signal Processing, which have been held annually since 2002 to provide the participants state-of-the-art knowledge on emerging areas in biomedical engineering. Prominent experts in the areas of biomedical signal processing, biomedical data treatment, medicine, signal processing, system biology, and applied physiology introduce novel techniques and algorithms as well as their clinical or physiological applications. The book provides an overview of a compelling group of advanced biomedical signal processing techniques, such as multisource and multiscale integration of information for physiology and clinical decision; the impact of advanced methods of signal processing in cardiology and neurology; the integration of signal processing methods with a modelling approach; complexity measurement from biomedical signals; higher order analysis in biomedical signals; advanced methods of signal and data processing in genomics and proteomics; and classification and parameter enhancement.

Models of Calcium Signalling

Models of Calcium Signalling Book
Author : Geneviève Dupont,Martin Falcke,Vivien Kirk,James Sneyd
Publisher : Springer
Release : 2016-06-07
ISBN : 3319296477
Language : En, Es, Fr & De

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Book Description :

This book discusses the ways in which mathematical, computational, and modelling methods can be used to help understand the dynamics of intracellular calcium. The concentration of free intracellular calcium is vital for controlling a wide range of cellular processes, and is thus of great physiological importance. However, because of the complex ways in which the calcium concentration varies, it is also of great mathematical interest.This book presents the general modelling theory as well as a large number of specific case examples, to show how mathematical modelling can interact with experimental approaches, in an interdisciplinary and multifaceted approach to the study of an important physiological control mechanism. Geneviève Dupont is FNRS Research Director at the Unit of Theoretical Chronobiology of the Université Libre de Bruxelles; Martin Falcke is head of the Mathematical Cell Physiology group at the Max Delbrück Center for Molecular Medicine, Berlin; Vivien Kirk is an Associate Professor in the Department of Mathematics at the University of Auckland, New Zealand; James Sneyd is a Professor in the Department of Mathematics at The University of Auckland, New Zealand.

Advanced Methods of Physiological System Modeling

Advanced Methods of Physiological System Modeling Book
Author : V.Z. Marmarelis
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 1461397898
Language : En, Es, Fr & De

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Book Description :

This volume is the second in a series of publications sponsored by the Biomedical Simulations Resource (BMSR) at the University of Southern California that report on recent research developments in the area of physiological systems modeling and anal ysis of physiological signals. As in the first volume of this series, the work reported herein is concerned with the development of advanced methodologies and their novel application to problems of biomedical interest, with emphasis on nonlinear aspects of physiological function. The term "advanced methodologies" is used to indicate that the scope of this work extends beyond the ordinary type of analysis used by most investigators in this area, which is confined primarily in the linear domain. As the im portance of nonlinearities in understanding the complex mechanisms of physiological function is increasingly recognized, the need for effective and practical methodolo gies that address the issue of nonlinear dynamics in life sciences becomes more and more pressing. The publication of these volumes and the workshops, organized by the BMSR on the same subject, are two key activities in our efforts to promote and intensify research in this area, foster interaction and collaboration among interested investigators, and disseminate recent results throughout the biomedical community.

Proceedings of a Special Symposium on Critical Emerging Issues in Biomedical Engineering

Proceedings of a Special Symposium on Critical Emerging Issues in Biomedical Engineering Book
Author : Charles J. Robinson,George V. Kondraske
Publisher : Unknown
Release : 1986
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This a partial contents listing by general subject areas: artificial organs; biosensors; bioelectric phenomena; intelligent devices, systems and models; tissue-field interaction and electromagnetic compatibility; critical care and operating room monitoring; rehabilitation engineering; medical imaging; The symposium schedule is included.