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Modelling And Control Of Drug Delivery Systems

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Modeling and Control of Drug Delivery Systems

Modeling and Control of Drug Delivery Systems Book
Author : Ahmad Taher Azar
Publisher : Academic Press
Release : 2021-02-06
ISBN : 0128211954
Language : En, Es, Fr & De

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Book Description :

Modeling and Control of Drug Delivery Systems provides comprehensive coverage of various drug delivery and targeting systems and their state-of-the-art related works, ranging from theory to real-world deployment and future perspectives. Various drug delivery and targeting systems have been developed to minimize drug degradation and adverse effect and increase drug bioavailability. Site-specific drug delivery may be either an active and/or passive process. Improving delivery techniques that minimize toxicity and increase efficacy offer significant potential benefits to patients and open up new markets for pharmaceutical companies. This book will attract many researchers working in DDS field as it provides an essential source of information for pharmaceutical scientists and pharmacologists working in academia as well as in the industry. In addition, it has useful information for pharmaceutical physicians and scientists in many disciplines involved in developing DDS, such as chemical engineering, biomedical engineering, protein engineering, gene therapy. Presents some of the latest innovations of approaches to DDS from dynamic controlled drug delivery, modeling, system analysis, optimization, control and monitoring Provides a unique, recent and comprehensive reference on DDS with the focus on cutting-edge technologies and the latest research trends in the area Covers the most recent works, in particular, the challenging areas related to modeling and control techniques applied to DDS

Model Based and Parametric Control for Drug Delivery Systems

Model Based and Parametric Control for Drug Delivery Systems Book
Author : Pinky Dua
Publisher : Unknown
Release : 2005
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Model Based and Parametric Control for Drug Delivery Systems book written by Pinky Dua, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Modelling Optimization and Control of Biomedical Systems

Modelling Optimization and Control of Biomedical Systems Book
Author : Efstratios N. Pistikopoulos,Ioana Nascu,Eirini G. Velliou
Publisher : John Wiley & Sons
Release : 2018-01-09
ISBN : 1118965590
Language : En, Es, Fr & De

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Book Description :

Shows the newest developments in the field of multi-parametric model predictive control and optimization and their application for drug delivery systems This book is based on the Modelling, Control and Optimization of Biomedical Systems (MOBILE) project, which was created to derive intelligent computer model-based systems for optimization of biomedical drug delivery systems in the cases of diabetes, anaesthesia, and blood cancer. These systems can ensure reliable and fast calculation of the optimal drug dosage without the need for an online computer—while taking into account the specifics and constraints of the patient model, flexibility to adapt to changing patient characteristics and incorporation of the physician’s performance criteria, and maintaining the safety of the patients. Modelling Optimization and Control of Biomedical Systems covers: mathematical modelling of drug delivery systems; model analysis, parameter estimation, and approximation; optimization and control; sensitivity analysis & model reduction; multi-parametric programming and model predictive control; estimation techniques; physiologically-based patient model; control design for volatile anaesthesia; multiparametric model based approach to intravenous anaesthesia; hybrid model predictive control strategies; Type I Diabetes Mellitus; in vitro and in silico block of the integrated platform for the study of leukaemia; chemotherapy treatment as a process systems application; and more. Introduces readers to the Modelling, Control and Optimization of Biomedical Systems (MOBILE) project Presents in detail the theoretical background, computational tools, and methods that are used in all the different biomedical systems Teaches the theory for multi-parametric mixed-integer programming and explicit optimal control of volatile anaesthesia Provides an overview of the framework for modelling, optimization, and control of biomedical systems This book will appeal to students, researchers, and scientists working on the modelling, control, and optimization of biomedical systems and to those involved in cancer treatment, anaesthsia, and drug delivery systems.

Modeling and Control of a Magnetic Drug Delivery System

Modeling and Control of a Magnetic Drug Delivery System Book
Author : Sepideh Afshar
Publisher : Unknown
Release : 2012
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Therapeutic operation risk has been reduced by the use of micro-robots, allowing highly invasive surgery to be replaced by low invasive surgery (LIS), which provides an effective tool even in previously inaccessible parts of the human body. LIS techniques help delivering drugs effectively via micro-carriers. The micro-carriers are divided into two groups: tethered devices, which are supported by internally supplied propulsion mechanism, and untethered devices. Remote actuation is the critical issue in micro-device navigation, especially through blood vessels. To achieve remote control within the cardiovascular system, magnetic propulsion offers an advantage over other proposed actuation methods. In the literature, most research has focused on micro-device structural design, while there is a lack of research into design and analysis of combined structure and control. As the main part, integrating the principle of electromagnetic induced force by feedback control design will lead to the desired automatic movement. An actuator configuration should thus first be designed to initiate the desired force. The design is basically defining the type and placement of a set of coils to achieve an operational goal. In this project, the magnetic actuation is initiated by a combination of four electromagnets and two sets of uniform coils. Preliminary studies on 2D navigation of a ferromagnetic particle are used to show the effect of actuator structure on controller performance. Accordingly, the performance of the four electromagnets combination is compared to the proposed augmented structure with uniform coils. The simulation results show the improved efficiency of the augmented structure. In more general cases, the arrangement and number of electromagnets are unknown and should be defined. An optimization method is suggested to find these variables when the working space is maximized. Finally, the problem of robust output regulation of the electromagnetic system driven by a linear exosystem, is also addressed in this project. The exosystem is assumed to be neutrally stable with unknown frequencies. The parallel connection of two controllers, a robust stabilizer and an internal model-based controller, is presented to eliminate the output error. In the latter one, an adaptation is used to tune the internal model frequencies such that a steady-state control is produced to maintain the output-zeroing condition. The robust regulation with a local domain of convergence is achieved for a special class of decomposable MIMO nonlinear minimum-phase system. The simulation results show the effectiveness and robustness of this method for the electromagnetic system when two different paths are considered.

Intelligent Sensory Evaluation

Intelligent Sensory Evaluation Book
Author : Da Ruan,Xianyi Zeng
Publisher : Springer Science & Business Media
Release : 2013-03-09
ISBN : 366207950X
Language : En, Es, Fr & De

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Book Description :

In today's industrial companies, sensory evaluation is widely used in quality inspection of products, in marketing study and in many other fields such as risk evaluation, investment evaluation and safety evaluation. This book collects a number of representative methods on sensory evaluation. The book reports recent research results and provides a state of the art on intelligent techniques-based sensory evaluation in industrial applications. The focus is especially on theoretical/analytical solutions to the problems of real interest in intelligent techniques with applications to engineers and managers of different industrial departments such as production, quality inspection, product design and development and marketing.

Controlled Release in Oral Drug Delivery

Controlled Release in Oral Drug Delivery Book
Author : Clive G. Wilson,Patrick J. Crowley
Publisher : Springer Science & Business Media
Release : 2011-09-22
ISBN : 9781461410041
Language : En, Es, Fr & De

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Book Description :

Controlled Release in Oral Drug Delivery provides focus on specific topics, complementing other books in the initial CRS series. Each chapter sets the context for the inventions described and describe the latitude that the inventions allow. In order to provide some similar look to each chapter, the coverage includes the historical overview, candidate drugs, factors influencing design and development, formulation and manufacturing and delivery system design. This volume was written along three main sections: the relevant anatomy and physiology, a discussion on candidates for oral drug delivery and the major three groups of controlled release systems: diffusion control (swelling and inert matrices); environmental control (pH sensitive coatings, time control, enzymatic control, pressure control) and finally lipidic systems.

Bioavailability Control by Drug Delivery System Design

Bioavailability Control by Drug Delivery System Design Book
Author : Victor F. Smolen,LuAnn Ball
Publisher : Wiley-Interscience
Release : 1985
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Bioavailability Control by Drug Delivery System Design book written by Victor F. Smolen,LuAnn Ball, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Encyclopedia of Optimization

Encyclopedia of Optimization Book
Author : Christodoulos A. Floudas,Panos M. Pardalos
Publisher : Springer Science & Business Media
Release : 2008-09-04
ISBN : 0387747583
Language : En, Es, Fr & De

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Book Description :

The goal of the Encyclopedia of Optimization is to introduce the reader to a complete set of topics that show the spectrum of research, the richness of ideas, and the breadth of applications that has come from this field. The second edition builds on the success of the former edition with more than 150 completely new entries, designed to ensure that the reference addresses recent areas where optimization theories and techniques have advanced. Particularly heavy attention resulted in health science and transportation, with entries such as "Algorithms for Genomics", "Optimization and Radiotherapy Treatment Design", and "Crew Scheduling".

Quantitative Systems Pharmacology

Quantitative Systems Pharmacology Book
Author : Davide Manca
Publisher : Elsevier
Release : 2018-07-18
ISBN : 0444639675
Language : En, Es, Fr & De

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Book Description :

Quantitative Systems Pharmacology: Models and Model-Based Systems with Applications, Volume 42, provides a quantitative approach to problem-solving that is targeted to engineers. The book gathers the contributions of doctors, pharmacists, biologists, and chemists who give key information on the elements needed to model a complex machine like the human body. It presents information on diagnoses, administration and release of therapeutics, distribution metabolism and excretion of drugs, compartmental pharmacokinetics, physiologically-based pharmacokinetics, pharmacodynamics, identifiability of models, numerical methods for models identification, design of experiments, in vitro and in vivo models, and more. As the pharma community is progressively acknowledging that a quantitative and systematic approach to drug administration, release, pharmacokinetics and pharmacodynamics is highly recommended to understand the mechanisms and effects of drugs, this book is a timely resource. Outlines a model-based approach (based on Process Systems Engineering-OSE and Computer Aided Process Engineering-CAPE) in quantitative pharmacology Explains how therapeutics work in the human body and how anatomy and physiology influences drug efficacy Discusses how drugs are driven to specific targets using nanoparticles Offers insight into how in vitro and in vivo experiments help understand the drug mechanism of action and optimize their performance Includes case studies showing the positive outcome of these methods in personalized therapies, therapeutic drug monitoring, clinical trials analysis and drug formulation

Modelling Drug Delivery Mechanisms for Microencapsulated Substances Applied on Textile Substracts

Modelling Drug Delivery Mechanisms for Microencapsulated Substances Applied on Textile Substracts Book
Author : Núria Carreras Parera
Publisher : Unknown
Release : 2013
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Mathematical drug release modelling of biodegradable polymeric systems by microencapsulation technology in textiles has not progressed much yet, because it is generally too complex. The release of a therapeutic agent from a formulation applied to the skin surface and its transport to the systemic circulation has a multistep process. The transdermal drug released is a feasible administration route for powerful, low-molecular weight therapeutic agents, which has to be accurate in their control of drug distribution. Moreover, many drugs are difficult to handle because they must be delivered slowly over a prolonged period to have a beneficial effect. In the present work, several examples of practical applications of mathematical models, developed through experimental drug release data, are given. For those involved in the design and development of biodegradable drug delivery systems, it will be useful to choose the generic mathematical model for several specific drug release problems. This transport model is based on the appropriate solution to Fick's second law of diffusion and can be used to explain drug release kinetics into this complex biological membrane (skin). Microspheres containing active principles were prepared using a solvent evaporation procedure with poly(vinyl alcohol) as surfactant in the external aqueous phase. Several biodegradable microspheres of biocompatible polymers, taken as delivery systems for active agent, have been studied. Polymers were PLGA (Poly(lactide-co-glycolide)) and PCL (poly(e-caprolactone)). The active compounds chosen were cosmetics and drugs, such as gallic acid, caffeine and ibuprofen. The microspheres obtained were characterized by the measure of encapsulation efficiency. The surface morphology and chemical structure of the micro particles were investigated using scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FT-IR). Nanosizer was used for particle size distribution. The application of the microspheres in the fabrics was carried out using Pad-Dry technique, since it is a simple and efficient technology and its working conditions are harmless to the system. The drug release system was analyzed, through samples of the treated fibre (cotton, polyamide, acrylic and polyester) in order to study the drug delivery behaviour in different media, deionized water and physiological saline (T=37oC). The skin penetration profile by in vitro technique for different active principles was determined using pigskin. The release experiments are performed resorting to the Franz Diffusion cells apparatus (Lara-Spiral, Courtenon, France) consisting of two thermostatic chambers, the upper donor and the lower receptor chamber, divided by a skin biopsy. The main objective of this study is to create smart textiles which allow a controlled drug release for any active compound/substance. Such objective will allow the control of the textiles drug release in such a way that the active compound is released in the right quantity, at the right time and at the right place. The present study has shown that the main objective has been successfully achieved. According to that, microencapsulation applied on fabrics can be considered as a good controlled release system. As a result, the project reached to a general kinetic model using smart textiles as a mass transport system through the skin.

Theoretical Prediction of Drug Release in GI Tract from Spherical Matrix Systems

Theoretical Prediction of Drug Release in GI Tract from Spherical Matrix Systems Book
Author : Naga Lakshmi Ramana Susarla
Publisher : Unknown
Release : 2011
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The significance of controlled release drug delivery systems (CRDDS) lies in their ability to deliver the drug at a steady rate thus reducing the dosage interval and providing a prolonged pharmacodynamic effect. But despite the steadily increasing practical importance of these devices, little is known regarding their underlying drug release mechanisms. Mathematical modeling of these drug delivery systems could help us understand the underlying mass transport mechanisms involved in the control of drug release. Mathematical modeling also plays an important role in providing us with valuable information such as the amount of drug released during a certain period of time and when the next dosage needs to be administered. Thus, potentially reducing the number of in-vitro and in-vivo experiments which in some cases are infeasible. There is a large spectrum of published mathematical models for predicting drug release from CRDDS in vitro following conventional approaches. These models describe drug release from various types of controlled delivery devices for perfect sink conditions. However in a real system (human body) a sink condition may not be applicable. For a CRDDS along with the physiochemical properties (solubility, diffusion, particle size, crystal form etc.) the physiological factors such as gastrointestinal tract (GI) pH, stomach emptying, (GI) motility, presence of food, elimination kinetics etc., also affect the rate of drug release. As the drug delivery system is expected to stay in the human body for a longer period of time when compared to a immediate release dosage form the process of drug release occurs in conjunction with the absorption (for oral delivery systems) and elimination kinetics. Earlier work by Ouruemchi et.al.[71] include prediction of the plasma drug concentration for an oral diffusion controlled drug delivery system. Amidon et.al.[68] developed several models for predicting the amount of drug absorbed within through the intestine walls for immediate release dosage forms. However none of these models study the effect of absorption rate on the rate of drug release for an oral controlled drug delivery system. In this work mathematical models are developed for prediction of drug release from both diffusion controlled and dissolution controlled drug delivery systems taking into account the affect of absorption rate. Spherical geometry of the particles is considered. The model is developed by assuming that the drug is release into a finite volume and is thereby absorbed through the intestine wall following first order kinetics. A closed form solution is obtained for the prediction of fraction of drug released for a diffusion controlled drug delivery system. The results are compared with both experimental data (taken from literature) as well as existing models in the literature. Whereas for a dissolution-diffusion controlled drug delivery system non linear dissolution kinetics are taken into consideration and the problem is solved by both numerical and analytical techniques. In addition two simple models are also presented for dissolution controlled drug delivery devices.

Practical Aspects of Chemical Engineering

Practical Aspects of Chemical Engineering Book
Author : Marek Ochowiak,Szymon Woziwodzki,Piotr Tomasz Mitkowski,Michał Doligalski
Publisher : Springer Nature
Release : 2020-05-08
ISBN : 3030398676
Language : En, Es, Fr & De

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Book Description :

This book discusses chemical engineering and processing, presenting selected contributions from PAIC 2019. It covers interdisciplinary technologies and sciences, like drug-delivery systems, nanoscale technology, environmental control, modelling and computational methods. The book also explores interdisciplinary aspects of chemical and biochemical engineering interconnected with process system engineering, process safety and computer science.

Transdermal Drug Delivery Systems

Transdermal Drug Delivery Systems Book
Author : Jonathan Hadgraft
Publisher : CRC Press
Release : 2002-10-29
ISBN : 1135565198
Language : En, Es, Fr & De

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Book Description :

Presents authoritative state-of-the-art discussions of the key issues pertinent to transdermal drug delivery, examining those topics necessary to enable a critical evaluation of a drug candidate's potential to be delivered across the skin; from physical chemistry and assessment of drug permeability to available enhancement technolgies, to regulator

Drug Delivery Systems

Drug Delivery Systems Book
Author : Kewal K. Jain
Publisher : Springer Science & Business Media
Release : 2008-03-07
ISBN : 1588298914
Language : En, Es, Fr & De

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Book Description :

In this concise and systematic book, a team of experts select the most important, cutting-edge technologies used in drug delivery systems. They take into account significant drugs, new technologies such as nanoparticles, and therapeutic applications. The chapters present step-by-step laboratory protocols following the highly successful Methods in Molecular BiologyTM series format, offering readily reproducible results vital for pharmaceutical physicians and scientists.

Fast Ferrous

Fast   Ferrous Book
Author : Vinura Ramal Jayaneththi
Publisher : Unknown
Release : 2020
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Magnetic polymer composites, or MPCs, are a class of material actuator that operate using magnetic fields. Similar to other soft material actuators, MPCs are capable of large strains, high stresses and quick response. The key feature of MPCs, however, is wireless, decoupled actuation. Wireless actuation removes the need for on-board electronics, computing, and power supply, thus allowing MPC-driven systems to operate in harsh environments, such as inside the body. Promising MPC applications include artificial muscle, lab-on-a-chip, and biomimetic robots. The unique features of MPCs position them as ideal candidates for biomedical applications. However, they also present a complex design challenge. Shape-change is coupled to the actuator’s material properties as well as the magnetic field stimulus (and field source itself). Due to the complexity and multi-physics nature of MPC systems, many questions remain concerning modelling, control and application. Hence, the motivation behind this work was to address these three knowledge gaps and develop a thorough understanding of wireless MPC systems. The ultimate goal of this research is to aid the development of MPC-driven devices. MPC modelling is important because it provides insight into how material properties, system configuration and physical geometries affect actuator performance. Previous studies on MPC modelling, however, have demonstrated limited or no experimental validation. The lack of validation has led to uncertainty surrounding model accuracy. This research presents two modelling approaches (equivalent systems and finite element) for simulating MPC deformation. Both models explicitly considered the electromagnet to simulate the entire system. Each method was validated and demonstrated good agreement against experimental data. Importantly, the developed models revealed the highly nonlinear nature of these wireless actuator systems and established accurate modelling tools for MPC device design. Actuators for robotics and biomedical applications require accuracy and precision. Given the nonlinearity of MPC systems, highlighted by the modelling work, error-free position tracking necessitates closed-loop control strategies. The infancy of the field has meant that MPC control has been neglected until now. This research revealed the requirement of nonlinear control methods for accurate MPC position tracking and variable stiffness control. Ultimately, this study unveiled the performance potential of MPC systems, proving these wireless systems are capable of sub-millimetre tracking accuracy and confirming their feasibility for robotic applications. Finally, this research identified a promising application of MPC in transdermal drug delivery. Transdermal drug delivery, i.e., delivering drug compounds to the dermal layers of skin, is undergoing a transformation due to microneedle technology. This work described the development of a battery-less drug delivery microneedle patch and highlighted the advantages of wireless MPC actuation. The novel device demonstrated on-demand, controllable drug release alongside accurate wireless dosage sensing. Altogether, this research contributes to the field by advancing modelling and control methods for MPC systems. The summation of this work establishes a toolkit for MPC design. With the newly gleaned insights into simulation techniques and MPC performance, novel uses for this wireless material actuator will become more apparent.

Assessing Bioavailablility of Drug Delivery Systems

Assessing Bioavailablility of Drug Delivery Systems Book
Author : Jean-Maurice Vergnaud,Iosif-Daniel Rosca
Publisher : CRC Press
Release : 2005-05-26
ISBN : 1420037854
Language : En, Es, Fr & De

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Book Description :

Exploring how to apply in vitro/in vivo correlations for controlled release dosage forms, Bioavailability of Drug Delivery Systems: Mathematical Modeling clearly elucidates this complex phenomena and provides a guide for the respective mathematical modeling. The book introduces mathematical modeling methods for calculating the profiles of plasma le

Treatise on Controlled Drug Delivery

Treatise on Controlled Drug Delivery Book
Author : Agis F. Kydonieus
Publisher : Routledge
Release : 2017-10-02
ISBN : 1351406876
Language : En, Es, Fr & De

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Book Description :

An introductory but detailed treatise which includes some 1,000 references and solved examples and end-of-chapter problems, making it useful to both students and practitioners. The pharmokinetics, pharmacodynamics, and biological and biopharmaceutical parameters pertinent to each route of administra

Artificial Neural Network for Drug Design Delivery and Disposition

Artificial Neural Network for Drug Design  Delivery and Disposition Book
Author : Munish Puri,Yashwant Pathak,Vijay Kumar Sutariya,Srinivas Tipparaju,Wilfrido Moreno
Publisher : Academic Press
Release : 2015-10-15
ISBN : 0128017449
Language : En, Es, Fr & De

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Book Description :

Artificial Neural Network for Drug Design, Delivery and Disposition provides an in-depth look at the use of artificial neural networks (ANN) in pharmaceutical research. With its ability to learn and self-correct in a highly complex environment, this predictive tool has tremendous potential to help researchers more effectively design, develop, and deliver successful drugs. This book illustrates how to use ANN methodologies and models with the intent to treat diseases like breast cancer, cardiac disease, and more. It contains the latest cutting-edge research, an analysis of the benefits of ANN, and relevant industry examples. As such, this book is an essential resource for academic and industry researchers across the pharmaceutical and biomedical sciences. Written by leading academic and industry scientists who have contributed significantly to the field and are at the forefront of artificial neural network (ANN) research Focuses on ANN in drug design, discovery and delivery, as well as adopted methodologies and their applications to the treatment of various diseases and disorders Chapters cover important topics across the pharmaceutical process, such as ANN in structure-based drug design and the application of ANN in modern drug discovery Presents the future potential of ANN-based strategies in biomedical image analysis and much more

Control of Biological and Drug Delivery Systems for Chemical Biomedical and Pharmaceutical Engineering

Control of Biological and Drug Delivery Systems for Chemical  Biomedical  and Pharmaceutical Engineering Book
Author : Laurent Simon
Publisher : John Wiley & Sons
Release : 2012-11-27
ISBN : 1118396480
Language : En, Es, Fr & De

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Book Description :

Enables readers to apply process dynamics and control theory to solve bioprocess and drug delivery problems The control of biological and drug delivery systems is critical to the health of millions of people worldwide. As a result, researchers in systems biology and drug delivery rely on process dynamics and control theory to build our knowledge of cell behavior and to develop more effective therapeutics, controlled release devices, and drug administration protocols to manage disease. Written by a leading expert and educator in the field, this text helps readers develop a deep understanding of process dynamics and control theory in order to analyze and solve a broad range of problems in bioprocess and drug delivery systems. For example, readers will learn how stability criteria can be used to gain new insights into the regulation of biological pathways and lung mechanics. They'll also learn how the concept of a time constant is used to capture the dynamics of diffusive processes. Readers will also master such topics as external disturbances, transfer functions, and input/output models with the support of the author's clear explanations, as well as: Detailed examples from the biological sciences and novel drug delivery technologies 160 end-of-chapter problems with step-by-step solutions Demonstrations of how computational software such as MATLAB and Mathematica solve complex drug delivery problems Control of Biological and Drug-Delivery Systems for Chemical, Biomedical, and Pharmaceutical Engineering is written primarily for undergraduate chemical and biomedical engineering students; however, it is also recommended for students and researchers in pharmaceutical engineering, process control, and systems biology. All readers will gain a new perspective on process dynamics and control theory that will enable them to develop new and better technologies and therapeutics to treat human disease.