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Modeling Neuropsychiatric Disorders In Laboratory Animals

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Modeling Neuropsychiatric Disorders in Laboratory Animals

Modeling Neuropsychiatric Disorders in Laboratory Animals Book
Author : Kurt Leroy Hoffman
Publisher : Woodhead Publishing
Release : 2015-08-28
ISBN : 0081001061
Language : En, Es, Fr & De

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Book Description :

Modeling Neuropsychiatric Disorders in Laboratory Animals serves as a guide for students and basic investigators in the fields of behavioral sciences, psychology, neuroscience, psychiatry, and other professionals interested in the use of animal models in preclinical research related to human neuropsychiatric disorders. The text focuses on the rationale and theory of using animal behavior, both pathological and normal, as a tool for understanding the neural underpinnings of neuropsychiatric disorders. Chapters contain discussions on both classical and modern views on the validation of animal models for neuropsychiatric disorders, also discussing the utility of endophenotypes in modeling neuropsychiatric disease. Subsequent chapters deal with four specific classes of disorders, including anxiety disorders, depressive disorders, obsessive-compulsive and related disorders. Final sections discuss the future for the development, validation, and use of animal models in basic and preclinical research. Focuses on the rationale and theory of using animal behavior, both pathological and normal, as a tool for understanding the neural underpinnings of neuropsychiatric disorders Serves as a guide for students and basic investigators in the fields of behavioral sciences, psychology, neuroscience, psychiatry, and other professionals Discusses specific classes of disorders, including anxiety disorders, depressive disorders, obsessive-compulsive and related disorders

Animal Models of Neurological Disease II

Animal Models of Neurological Disease  II Book
Author : Alan A. Boulton,Glen B. Baker,Roger F. Butterworth
Publisher : Humana
Release : 2013-08-11
ISBN : 9781489943897
Language : En, Es, Fr & De

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Book Description :

to the Animal Models Volumes This and several other volumes in the Neuromethods series will describe a number of animal models of neuropsychiatric disorders. Because of increasing public concern over the ethical treatment of animals in research, we felt it incumbent upon us to include this general preface to these volumes in order to indicate why we think further - search using animals is necessary and why animal models of psychiatric disorders, in particular, are so important. We recognize that animals should only be used when suitable alternatives are not available. We think it self-e- dent, however, that humans can only be experimented upon in severely proscribed circumstances and alternative pro- dures using cell or tissue culture are inadequate in any models requiring assessments of behavioral change or of complex in vivo processes. However, when the distress, discomfort, or pain to the animals outweighs the anticipated gains for human welfare, then the research is not ethical and should not be carried out. It is imperative that each individual researcher examine his/her own research from a critical moral standpoint - fore engaging in it, taking into consideration the animals’ welfare as well as the anticipated gains. Furthermore, once a decision to proceed with research is made, it is the researcher’s responsibility to ensure that the animals’ w- fare is of prime concern in terms of appropriate housing, feeding, and maximum reduction of any uncomfortable or distressing effects of the experimental conditions, and that these conditions undergo frequent formalized monitoring.

Endophenotypes Of Psychiatric And Neurodegenerative Disorders In Rodent Models

Endophenotypes Of Psychiatric And Neurodegenerative Disorders In Rodent Models Book
Author : Sylvie Granon
Publisher : Unknown
Release : 2009-01-01
ISBN : 9788178954028
Language : En, Es, Fr & De

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Book Description :

Psychiatric disorders are uniquely human. Yet we need animal models to test hypotheses about biological mechanisms. Treatment development relies on model systems to evaluate the efficacy of therapeutics. How can such a profound paradox be resolved? Dr. Sylvie Granon of the Institute Pasteur in Paris has successfully assembled a collection of fifteen review chapters that address multiple aspects of rodent models of neuropsychiatric disorders. Outstanding experts describe paradigms relevant to Alzheimer s disease, mental retardation, schizophrenia, autism, attentional deficit hyperactivity disorder, impulsivity, drug addiction, post-traumatic stress disorder, multiple sclerosis, and sudden infant death syndrome. Traditional lesioning and pharmacological methods are contrasted with newer targeted gene mutation strategies for generating rodent models. Strengths and limitations of transgenic and knockout mouse models are discussed by many of the insightful authors. In Alice in Wonderland, the Cheshire Cat speaks English and tell us We re all mad here. Unfortunately, real animals do not talk, and cannot tell us about their abnormal internal emotional or mental states, if any. It is essential to recognize that researchers will never be able to replicate schizophrenia or autism or depression in a mouse. Many psychiatric dysfunctions appear to originate primarily in the human frontal cerebral cortex, a highly developed structure that dramatically eclipses the modest frontal cortex of rodents. Numbers of synapses and available pathways for making neural connections that permit higher executive functions are enormously greater in humans as compared to other species. Expansion of the human prefrontal cortex is an evolutionary recent phenomenon. There has not been enough time for thorough trouble-shooting and beta-testing of its neural circuitry. No wonder so much can go so wrong. Endophenotypes offer a neat solution to our conundrum. Rather than trying to replicate the full human syndrome, specific components of behavioral symptoms and neuroanatomical abnormalities can be modeled in rodents. While mental illnesses that are primarily caused by incorrect developmental neuroanatomy or aberrant neurotransmitter pharmacology in the prefrontal cortex may be difficult to model in mice, whose prefrontal cortex is minimal, connections between frontal cortex and other brain regions such as thalamus are similar across species. Homologies between rodents and primates in frontal cortex connections and specific behavioral functions have been extensively described by Bryan Kolb. The inability of Alzheimer s patients to store new memories represents a discrete characteristic that can be paralleled in rats and mice, who store new memories using similar neurophysiological mechanisms. Schizophrenic patients display deficits in sensorimotor gating and errors in working memory. Very similar procedures and equipment are available to assay prepulse inhibition and working memory in humans, monkeys, rats, and mice. Neuropharmacological pathways mediating the biological actions of abused drugs are similar in humans and rats. Drug addicts show poor impulse control and poor decision making in tasks that are analogous to some forms of errors in the five choice serial reaction time task for rats and mice. Genetic mutations that produce synaptic dysfunctions or amyloid plaques in the human brain are inserted into the mouse genome to create mouse models of mental retardation, which are then evaluated on learning and memory tasks. Thus, a simpler focus on individual endophenotype components of a human disease permits reasonable analogies to be generated in model organisms. The ideal animal model of a human syndrome is quantitative, readily replicated across laboratories, and incorporates three types of validity. Face validity is the conceptual analogy to a human symptom or endophenotype. Some unusual social behaviors in mice offer a conceptual analogy to the first diagnostic symptom of autism, abnormal reciprocal social interactions. Construct validity employs the same cause or precipitating event in the animal model and the human disease. Inflammatory demyelination presents construct validity for a rodent model of multiple sclerosis. Predictive validity confirms the specific therapeutic response. Treatments that work in the human disease also work in the animal model. For example, antidepressants that are effective in treating post-traumatic stress disorder should effectively reverse the behavioral traits of a rat model of this syndrome. Very few animal models of neuropsychiatric diseases incorporate all three types of validity. The authors contributing to this volume explain the challenges, failures and successes of an impressively wide range of model organisms. As the true causes of mental illnesses are identified, neuroscientists and pharmaceutical researchers will design more targeted model systems with true construct validity to the etiologies of neuropsychiatric syndromes. Behavioral assays will continue to be invented and refined to optimize face validity to the endophenotypes of the human disease. Ultimately these endeavors will result in model organisms with high predictive validity and translational value, to enhance the discovery of effective cures for debilitating major mental illnesses.

Animal Models Of Neuropsychiatric Diseases

Animal Models Of Neuropsychiatric Diseases Book
Author : Michael Koch
Publisher : World Scientific
Release : 2006-05-11
ISBN : 1783260068
Language : En, Es, Fr & De

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Book Description :

Animal models of neuro- and psychopathological states in humans are an indispensable part of both experimental neurology and biological psychiatry. Written by a team of experts, this book provides an up-to-date detailed overview of the current approaches to the design of viable animal models for eight prominent neuropsychiatric diseases. The book is specifically written with the research-oriented reader in mind — both in academia and the pharmaceutical industry. It contains first-hand information on how to design viable animal models for Alzheimer's disease, epilepsy, Huntington's disease, Parkinson's disease, addiction, depression, fear and anxiety, and schizophrenia. Each chapter also critically discusses the limitations of the animal experimental approach towards an understanding of human neuropsychiatric disorders.The book is an essential source of reference for researchers who seek to successfully continue and elaborate the experimental work that will finally lead to a better understanding of the neurobiological basis of the diseases, as well as to an improvement of both diagnosis and therapy.

Animal Models of Neurological Disease II

Animal Models of Neurological Disease  II Book
Author : Alan A. Boulton,Glen B. Baker,Roger F. Butterworth
Publisher : Humana Press
Release : 1992-07-29
ISBN : 9780896032118
Language : En, Es, Fr & De

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Book Description :

to the Animal Models Volumes This and several other volumes in the Neuromethods series will describe a number of animal models of neuropsychiatric disorders. Because of increasing public concern over the ethical treatment of animals in research, we felt it incumbent upon us to include this general preface to these volumes in order to indicate why we think further - search using animals is necessary and why animal models of psychiatric disorders, in particular, are so important. We recognize that animals should only be used when suitable alternatives are not available. We think it self-e- dent, however, that humans can only be experimented upon in severely proscribed circumstances and alternative pro- dures using cell or tissue culture are inadequate in any models requiring assessments of behavioral change or of complex in vivo processes. However, when the distress, discomfort, or pain to the animals outweighs the anticipated gains for human welfare, then the research is not ethical and should not be carried out. It is imperative that each individual researcher examine his/her own research from a critical moral standpoint - fore engaging in it, taking into consideration the animals’ welfare as well as the anticipated gains. Furthermore, once a decision to proceed with research is made, it is the researcher’s responsibility to ensure that the animals’ w- fare is of prime concern in terms of appropriate housing, feeding, and maximum reduction of any uncomfortable or distressing effects of the experimental conditions, and that these conditions undergo frequent formalized monitoring.

Transgenic and Knockout Models of Neuropsychiatric Disorders

Transgenic and Knockout Models of Neuropsychiatric Disorders Book
Author : Gene S. Fisch,Jonathan Flint
Publisher : Springer Science & Business Media
Release : 2007-11-06
ISBN : 1597450588
Language : En, Es, Fr & De

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Book Description :

In this up-to-date survey and critical assessment of transgenic and knockout models in neuropsychiatry and behavior, a panel of leading researchers comprehensively assesses how and whether the genetic abnormalities produced from these models manifest the neuropsychiatric disorders to which they correspond. The authors focus on transgenic and knockout models of neurocognitive dysfunction and neuropsychiatric dysfunction. The discussion of neurobiological problems covers mental retardation, polyglutamate, and speech disorders, as well as disorders that involve cognitive, social, speech, and language dysfunction. The neuropsychiatric dysfunctions examined include psychosis and schizophrenia, anxiety, depression, and bipolar disorder.

Animal Models of Neurological Disease I

Animal Models of Neurological Disease  I Book
Author : Alan A. Boulton,Glen B. Baker,Roger F. Butterworth
Publisher : Humana Press
Release : 2013-08-18
ISBN : 9781489940223
Language : En, Es, Fr & De

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Book Description :

to the Animal Models Volumes This and several other volumes in the Neuromethods series will describe a number of animal models of neu- psychiatric disorders. Because of increasing public concern over the ethical treatment of animals in research, we felt it incumbent upon us to include this general preface to these volumes in order to indicate why we think further research using animals is necessary and why animal models of psychi- ric and neurologic disorders, in particular, are so important. We recognize that animals should only be used when suitable alternatives are not available. We think it self-e- dent, however, that humans can only be experimented upon in severely proscribed circumstances and alternative pro- dures using cell or tissue culture are inadequate in any models requiring assessments of behavioral change or of complex in vivo processes. However, when the distress, discomfort, or pain to the animals outweighs the anticipated gains for human welfare, then the research is not ethical and should not be carried out.

Therapy and the Neural Network Model

Therapy and the Neural Network Model Book
Author : Theodore Wasserman,Lori Drucker Wasserman
Publisher : Springer Nature
Release : 2019-10-16
ISBN : 3030269213
Language : En, Es, Fr & De

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Book Description :

This innovative work explores integrating emerging research into how the brain processes information in applied therapeutic interventions. Typically, clinicians select therapeutic interventions based on their own training, personal experience or preference. This book aims to provide a new model, based upon the neural networks, to both understand the development of mental health issues and their persistence, and how and why to apply therapeutic interventions to impact the systems which are maintaining them. This work begins with a short and accessible overview of the neural network model, and the general aims of therapy. It elucidates components of the neural network model of learning such as reward recognition, automaticity, and memory reconsolidation, and how they apply to both general learning and new learning through the process in therapy. Next, the authors explore how the neural network model can be integrated across existing systems of therapy, including Cognitive Behavior therapy (CBT), Dialectical Behavior Therapy (DBT), third wave therapies and analytic therapies. Therapy and the Neural Network Model is an exciting resource for researchers and practitioners interested in understanding more about the applications of a neural network model for therapy and the how and why of building new mentally healthy cognitions, behaviors and emotions. Therapy and the Neural Network Model is also an essential theoretical foundation for both researchers and practitioners who wish to base their therapeutic practice on neuroscience and integrate their work with related fields such as behavioral medicine, health psychology, social work and public health.

Animal Models of Neurological Disorders

Animal Models of Neurological Disorders Book
Author : Puneet Kumar Bansal,Rahul Deshmukh
Publisher : Springer
Release : 2018-01-17
ISBN : 9811059810
Language : En, Es, Fr & De

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Book Description :

This book introduces undergraduate, postgraduate and research students and scientists to animal models of neurological disorders, along with their working principle and brief procedures. Addressing all the disorders related to the central nervous system (CNS) in a single platform, on the basis of various literature surveys it describes different procedures to induce a single disease with the help of toxins/chemicals. It also includes numerous protocols for inducing single neurological diseases, thus fulfilling an urgent need for a book that makes specific procedures for neurological disorders available, so that specific disease can be induced in laboratories according to the availability of resources. Further, it acquaints readers with the pathological changes that occur in a particular neurological disorder, which reflect specific signs and symptoms of any particular disease, and examines how they affect everyday life. It is a valuable resource for researchers aiming to eradicate or improve neurological disorders by testing the benefits of different drugs.

Experimental Animal Models in Neurobehavioral Research

Experimental Animal Models in Neurobehavioral Research Book
Author : Allan V. Kalueff
Publisher : Nova Science Pub Incorporated
Release : 2009
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Behavioural research has been an exciting staple of the neuroscientific community's efforts in combating the rising challenges of mental healthcare. New innovations are bringing a greater understanding of the pathogenic mechanisms behind the disorders and allowing for progress towards their remedies. this translational approach, using newly developed animal modes, is of critical importance for the study of neuropsychiatric disorders. While the differences between the subjects of clinical research and basic research are obvious, there are many neurobiological similarities that allow for the possibility of creating an accurate animal analogue of a human disorder. These tools contribute to translational research and are the best hope for countering the challenges facing the field of mental health. This book provides chapters on a range of issues in biopsychology and behavioural neuroscience. It offers innovative methodological and conceptual advances regarding topics such as sleep, depression, and anxiety, as well as how these domains interact. All authors of the book are recognised experts in the field, and have written their chapters for an international audience of basic and clinical neuroscientists who are interested in behavioural neurophenotyping. The writing will also be accessible to students at the undergraduate level, while still providing an important update to graduate students and professional researchers in the disciplines of psychology, biology, and neuroscience on this rapidly developing field.

In vivo Models for Drug Discovery

In vivo Models for Drug Discovery Book
Author : José Miguel Vela,Rafael Maldonado,Michel Hamon
Publisher : John Wiley & Sons
Release : 2014-07-31
ISBN : 3527679367
Language : En, Es, Fr & De

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Book Description :

This one-stop reference is the first to present the complete picture -- covering all relevant organisms, from single cells to mammals, as well as all major disease areas, including neurological disorders, cancer and infectious diseases. Addressing the needs of the pharmaceutical industry, this unique handbook adopts a broad perspective on the use of animals in the early part of the drug development process, including regulatory rules and limitations, as well as numerous examples from real-life drug development projects. After a general introduction to the topic, the expert contributors from research-driven pharmaceutical companies discuss the basic considerations of using animal models, including ethical issues. The main part of the book systematically surveys the most important disease areas for current drug development, from cardiovascular to endocrine disorders, and from infectious to neurological diseases. For each area, the availability of animal models for target validation, hit finding and lead profiling is reviewed, backed by numerous examples of both successes and failures among the use of animal models. The whole is rounded off with a discussion of perspectives and challenges. Key knowledge for drug researchers in industry as well as academia.

Behavioral Models in Stress Research

Behavioral Models in Stress Research Book
Author : Allan V. Kalueff,Justin L. LaPorte
Publisher : Nova Publishers
Release : 2008
ISBN : 9781604563610
Language : En, Es, Fr & De

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Book Description :

Stress is an adaptive response that has developed throughout evolution, and is associated with multiple changes in the biochemistry, histology and physiology of an organism. As stress may induce or contribute to multiple neuropsychiatric disorders, the rigorous investigation of the neural substrates of stress has become a critical endeavour of contemporary biomedical science. This book explores the physiological responses that researchers have attempted to assess in stress-evoked behavioural changes, using both human and animal "experimental" models in clinical and non-clinical research. Though all aspects of the field have their challenges, animal experimental research of stress is a particularly difficult but meaningful task. This book provides succinct and relevant summaries of progress in the area of assessing stress response and the conditions contributing to it.

Psychiatric Disorders

Psychiatric Disorders Book
Author : Firas Kobeissy
Publisher : Humana Press
Release : 2012-01-10
ISBN : 9781617794599
Language : En, Es, Fr & De

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Book Description :

New high throughput techniques in neuroscience and psychiatry have enhanced the development of experimental, customizable animal models that are predictive of human neuropsychiatric pathology and give vital insights on the mechanisms and pathways involved. In Psychiatric Disorders: Methods and Protocols, key experts have written integrated chapters on neuropsychiatric research sharing their insightful expertise and opinions focusing on both the animal models as well as the cutting edge techniques applied. Beginning with an overview of the animal research in psychiatric illness and substance abuse, this comprehensive volume continues with the modeling of neuropsychiatric illness, drug abuse paradigms and techniques, biomarker identification, autoimmune inflammatory response, and neuroendocrine alteration in the areas of psychiatry, as well as state-of-the-art “Omics approaches” and neurosystems biology/data mining techniques to compute and analyze genomic and proteomics alteration occurring within neuropsychiatric models. As a part of the highly successful Methods in Molecular BiologyTM series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and easily applicable, Psychiatric Disorders: Methods and Protocols offers the detailed and clearly illustrated tools necessary for neuroscientists and psychiatrists to handle many unanswered scientific questions with a more creative and insightful approach.

Electrical Brain Stimulation in Psychiatric Disorders

Electrical Brain Stimulation in Psychiatric Disorders Book
Author : Kris Van Kuyck
Publisher : Leuven University Press
Release : 2006-11-30
ISBN : 9789058675545
Language : En, Es, Fr & De

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Book Description :

Download Electrical Brain Stimulation in Psychiatric Disorders book written by Kris Van Kuyck, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The Metaphor of the Monster

The Metaphor of the Monster Book
Author : Keith Moser,Karina Zelaya
Publisher : Bloomsbury Publishing USA
Release : 2020-10-15
ISBN : 1501364340
Language : En, Es, Fr & De

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Book Description :

The Metaphor of the Monster offers fresh perspectives and a variety of disciplinary approaches to the ever-broadening field of monster studies. The eclectic group of contributors to this volume represents areas of study not generally considered under the purview of monster studies, including world literature, classical studies, philosophy, ecocriticism, animal ethics, and gender studies. Combining historical overviews with contemporary and global outlooks, this volume recontextualizes the monstrous entities that have always haunted the human imagination in the age of the Anthropocene. It also invites reflection on new forms of monstrosity in an era epitomized by an unprecedented deluge of (mis)information. Uniting researchers from varied academic backgrounds in a common effort to challenge the monstrous labels that have historically been imposed upon "the Other," this book endeavors above all to bring the monster out of the shadows and into the light of moral consideration.

Stress and Mental Disorders

Stress and Mental Disorders Book
Author : Richard McCarty
Publisher : Oxford University Press, USA
Release : 2020
ISBN : 0190697261
Language : En, Es, Fr & De

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Book Description :

Stress has been recognized as an important factor in the development or recurrence of various mental disorders, from major depressive disorder to bipolar disorder to anxiety disorders. Stressful stimuli also appear to exert their effects by acting upon individuals with susceptible genotypes. Over the past 50 years, animal models have been developed to study these dynamic interactions between stressful stimuli and genetically susceptible individuals during prenatal and postnatal development and into adulthood. Stress and Mental Disorders: Insights from Animal Models begins with a discussion of the history of psychiatric diagnosis and the recent goal of moving toward precision psychiatry, followed by a review of clinical research on connections between stressful stimuli and the development of psychiatric disorders. Chapters are also included on neuroendocrine, immune, and brain systems involved in responses to stress. Additional chapters focus on the development of animal models in psychiatry and the susceptibility of the developing organism to stressful stimuli. Subsequent chapters are devoted to animal models of specific stress-sensitive psychiatric disorders, including schizophrenia, autism spectrum disorders, bipolar disorder, anxiety disorders, depression, and post-traumatic stress disorder. These chapters also focus on identification of promising molecular targets for development of new drug therapies. The section concludes with a chapter on animal models of resilience to stress-induced behavioral alterations as a newer approach to understanding why some animals are susceptible to stress and others are resilient, even though they are essentially genetically identical. The final chapter discusses how these basic laboratory studies are providing promising leads for future breakthroughs in the diagnosis, treatment, and prevention of mental disorders.

Addiction Treatment

Addiction Treatment Book
Author : Katherine van Wormer,Diane Rae Davis
Publisher : Cengage Learning
Release : 2016-12-05
ISBN : 1337514101
Language : En, Es, Fr & De

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Book Description :

ADDICTION TREATMENT covers the biological, psychological, and social aspects of alcoholism, eating disorders, compulsive gambling, and other addictions. The authors bridge the gap between the popular twelve-step and harm-reduction approaches, thus illuminating how practitioners can guide clients down a trusted path that is tailored towards the client's particular needs. Through a number of first-person narratives about the experience of addiction, students will discover a realism and depth not commonly found in textbooks. In addition, the authors include student-friendly topics, such as the case against so-called underage drinking laws, to draw students into the material and illustrate the importance of reducing harm within the biopsychological framework that ties the text together. Updated to reflect the DSM-5, this edition also includes the latest insights into social determinants of health, trauma-informed care, working with transgender populations, and other timely topics. Important Notice: Media content referenced within the product description or the product text may not be available in the ebook version.

Experimental Models in Serotonin Transporter Research

Experimental Models in Serotonin Transporter Research Book
Author : Allan V. Kalueff,Justin L. LaPorte
Publisher : Cambridge University Press
Release : 2010-03-04
ISBN : 1139482254
Language : En, Es, Fr & De

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Book Description :

The serotonin transporter is a key brain protein that modulates the reuptake of the neurotransmitter serotonin from synaptic spaces back into the presynaptic neuron. This control over neuronal signalling makes it a prime area of neuroscientific study. In this book an international team of top experts introduce and explicate the role of serotonin and the serotonin transporter in both human and animal brains. They demonstrate the relevance of the transporter and indeed the serotonergic system to substrates of neuropsychiatric disorders, and explain how this knowledge is translated into valid animal models that will help foster new discoveries in human neurobiology. Writing for graduate students and academic researchers, they provide a comprehensive coverage of a wide spectrum of data from animal experimentation to clinical psychiatry, creating the only book exclusively dedicated to this exciting new avenue of brain research.

Animal Models in Psychiatry I

Animal Models in Psychiatry  I Book
Author : Alan A. Boulton,Glen B. Baker,Mathew T. Martin-Iverson
Publisher : Springer Science & Business Media
Release : 1991-08-20
ISBN : 0896031985
Language : En, Es, Fr & De

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Book Description :

The two Animal Models in Psychiatry volumes are loosely organized by subject. The first volume contains a number of chapters concerned with schizophrenia, psyc- ses, neuroleptic-induced tardive dyskinesias, and other d- orders that may involve dopamine, such as attention deficit disorder and mania. The second volume deals with affective and anxiety disorders, but also includes chapters on subjects not easily classified as either psychotic, or affective, or an- ety-related, such as aggression, mental retardation, and memory disorders. Four chapters on animal models of schizophrenia or psychoses are included in the present v- ume because of the importance of these disorders in p- chiatry. Likewise, three chapters in the subsequent volume deal with depression. The first of the two volumes begins with an introd- tion by Paul Willner reviewing the criteria for assessing the validity of animal models in psychiatry. He has written - tensively on this subject, and his thorough description of the issues of various forms of validity provides a framework in which to evaluate the subsequent chapters. As will be seen, the remaining chapters in both volumes will refer frequently to these issues. The second chapter, by Melvin Lyon, describes a large number of different procedures that have been p- posed as potential animal models of schizophrenia. This is a departure from the usual format, consisting of detailed - scriptions of specific models.

The Cerebral Cortex in Neurodegenerative and Neuropsychiatric Disorders

The Cerebral Cortex in Neurodegenerative and Neuropsychiatric Disorders Book
Author : David F. Cechetto,Nina Weishaupt
Publisher : Academic Press
Release : 2017-02-24
ISBN : 0128019565
Language : En, Es, Fr & De

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Book Description :

The Cerebral Cortex in Neurodegenerative and Neuropsychiatric Disorders: Experimental Approaches to Clinical Issues focuses on how pre-clinical investigations are addressing the clinical issues surrounding the involvement of the cerebral cortex in selected conditions of the nervous system, including Alzheimer’s Disease, Parkinson’s, addiction, and cardiovascular dysregulation. Each chapter is written by an expert in his/her field who provides a comprehensive review of the clinical manifestations of cortical involvement and experimental techniques currently available to tackle cortical issues in disease. Thus, this present title provides a link between cortical clinical problems and investigational approaches to help foster future research with high translational value. Offers a comprehensive overview on the best available in vivo and in vitro models to study cortical involvement Presents models and specific techniques that help to guide investigators in their choices on how to address research questions experimentally Provides expert commentary and a perspective on future trends at the end of each chapter Addresses translational advances and promising therapeutic options Includes references to key articles for additional detailed study