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Modeling Neuropsychiatric Disorders In Laboratory Animals

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Modeling Neuropsychiatric Disorders in Laboratory Animals

Modeling Neuropsychiatric Disorders in Laboratory Animals Book
Author : Kurt Leroy Hoffman
Publisher : Woodhead Publishing
Release : 2015-08-28
ISBN : 0081001061
Language : En, Es, Fr & De

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Book Description :

Modeling Neuropsychiatric Disorders in Laboratory Animals serves as a guide for students and basic investigators in the fields of behavioral sciences, psychology, neuroscience, psychiatry, and other professionals interested in the use of animal models in preclinical research related to human neuropsychiatric disorders. The text focuses on the rationale and theory of using animal behavior, both pathological and normal, as a tool for understanding the neural underpinnings of neuropsychiatric disorders. Chapters contain discussions on both classical and modern views on the validation of animal models for neuropsychiatric disorders, also discussing the utility of endophenotypes in modeling neuropsychiatric disease. Subsequent chapters deal with four specific classes of disorders, including anxiety disorders, depressive disorders, obsessive-compulsive and related disorders. Final sections discuss the future for the development, validation, and use of animal models in basic and preclinical research. Focuses on the rationale and theory of using animal behavior, both pathological and normal, as a tool for understanding the neural underpinnings of neuropsychiatric disorders Serves as a guide for students and basic investigators in the fields of behavioral sciences, psychology, neuroscience, psychiatry, and other professionals Discusses specific classes of disorders, including anxiety disorders, depressive disorders, obsessive-compulsive and related disorders

Biomedical Index to PHS supported Research

Biomedical Index to PHS supported Research Book
Author : Anonim
Publisher : Unknown
Release : 1992
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Biomedical Index to PHS supported Research book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Research Awards Index

Research Awards Index Book
Author : Anonim
Publisher : Unknown
Release : 1982
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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New Oxford Textbook of Psychiatry

New Oxford Textbook of Psychiatry Book
Author : John R. Geddes,Nancy C. Andreasen
Publisher : Oxford University Press, USA
Release : 2020-02-20
ISBN : 0198713002
Language : En, Es, Fr & De

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Book Description :

Over its two editions, The New Oxford Textbook of Psychiatry has come to be regarded as one of the most popular and trusted standard psychiatry texts among psychiatrists and trainees. Bringing together 146 chapters from the leading figures in the discipline, it presents a comprehensive account of clinical psychiatry, with reference to its scientific basis and to the patient's perspective throughout. The New Oxford Textbook of Psychiatry, Third Edition has been extensively re-structured and streamlined to keep pace with the significant developments that have taken place in the fields of clinical psychiatry and neuroscience since publication of the second edition in 2009. The new edition has been updated throughout to include the most recent versions of the two main classification systems---the DSM-5 and the ICD-11---used throughout the world for the diagnosis of mental disorders. In the years since publication of the first edition, many new and exciting discoveries have occurred in the biological sciences, which are having a major impact on how we study and practise psychiatry. In addition, psychiatry has fostered closer ties with philosophy, and these are leading to healthy discussions about how we should diagnose and treat mental illness. This new edition recognises these and other developments. Throughout, accounts of clinical practice are linked to the underlying science, and to the evidence for the efficacy of treatments. Physical and psychological treatments, including psychodynamic approaches, are covered in depth. The history of psychiatry, ethics, public health aspects, and public attitudes to psychiatry and to patients are all given due attention.

Alcohol Research Health

Alcohol Research   Health Book
Author : Anonim
Publisher : Unknown
Release : 2000
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Alcohol Research Health book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Stress and Mental Disorders

Stress and Mental Disorders Book
Author : Richard McCarty
Publisher : Oxford University Press, USA
Release : 2020
ISBN : 0190697261
Language : En, Es, Fr & De

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Book Description :

Stress has been recognized as an important factor in the development or recurrence of various mental disorders, from major depressive disorder to bipolar disorder to anxiety disorders. Stressful stimuli also appear to exert their effects by acting upon individuals with susceptible genotypes. Over the past 50 years, animal models have been developed to study these dynamic interactions between stressful stimuli and genetically susceptible individuals during prenatal and postnatal development and into adulthood. Stress and Mental Disorders: Insights from Animal Models begins with a discussion of the history of psychiatric diagnosis and the recent goal of moving toward precision psychiatry, followed by a review of clinical research on connections between stressful stimuli and the development of psychiatric disorders. Chapters are also included on neuroendocrine, immune, and brain systems involved in responses to stress. Additional chapters focus on the development of animal models in psychiatry and the susceptibility of the developing organism to stressful stimuli. Subsequent chapters are devoted to animal models of specific stress-sensitive psychiatric disorders, including schizophrenia, autism spectrum disorders, bipolar disorder, anxiety disorders, depression, and post-traumatic stress disorder. These chapters also focus on identification of promising molecular targets for development of new drug therapies. The section concludes with a chapter on animal models of resilience to stress-induced behavioral alterations as a newer approach to understanding why some animals are susceptible to stress and others are resilient, even though they are essentially genetically identical. The final chapter discusses how these basic laboratory studies are providing promising leads for future breakthroughs in the diagnosis, treatment, and prevention of mental disorders.

Ethopharmacology Primate Models of Neuropsychiatric Disorders

Ethopharmacology  Primate Models of Neuropsychiatric Disorders Book
Author : Klaus A. Miczek
Publisher : Alan R. Liss
Release : 1983
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Ethopharmacology Primate Models of Neuropsychiatric Disorders book written by Klaus A. Miczek, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Postdoctoral Research Fellowship Opportunities

Postdoctoral Research Fellowship Opportunities Book
Author : National Institutes of Health (U.S.)
Publisher : Unknown
Release : 1995
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Postdoctoral Research Fellowship Opportunities book written by National Institutes of Health (U.S.), available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Directory of Federal Laboratory Technology Resources

Directory of Federal Laboratory   Technology Resources Book
Author : Anonim
Publisher : Unknown
Release : 1993
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

A locating tool for government-sponsored research and engineering projects situated in federal laboratories and engineering facilities. With the departments of agriculture, commerce, defense, energy, health and human services, Interior, transportation, The Environmental Protection Agency, NASA, The National Science Foundation, and The Veterans Administration. Also included is a listing of technology transfer contracts.

Serotonin in Major Psychiatric Disorders

Serotonin in Major Psychiatric Disorders Book
Author : Emil F. Coccaro,Dennis L. Murphy
Publisher : Amer Psychiatric Pub Incorporated
Release : 1990
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

A discussion of current strategies for the assessment of central serotonin system function as well as data regarding the various serotonergic hypotheses for different behavioural diseases, such as autism, schizophrenia and major psychiatric disorders.

Brain Behavior and Evolution

Brain  Behavior and Evolution Book
Author : Anonim
Publisher : Unknown
Release : 1991
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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Pharmacology

Pharmacology Book
Author : Anonim
Publisher : Unknown
Release : 1991-10
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Pharmacology book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Drug Discovery and Development

Drug Discovery and Development Book
Author : H. P. Rang,Daniel Vasella
Publisher : Churchill Livingstone
Release : 2006
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

'Drug Discovery and Development' describes the huge complexities involved in bringing a drug to market and how new molecular understanding and techniques can make the process more targeted and successful.

Alternatives to Laboratory Animals

Alternatives to Laboratory Animals Book
Author : Anonim
Publisher : Unknown
Release : 2006
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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Molecular Genetic Approaches to Neuropsychiatric Diseases

Molecular Genetic Approaches to Neuropsychiatric Diseases Book
Author : Jurgen Brosius,Jürgen Brosius,Robert T. Fremeau
Publisher : Unknown
Release : 1991
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Reviews recent advances in the molecular foundation of neurological diseases and discusses current work in the context of classical Mendelian genetics. The molecular techniques used to study genetic disease, as well as animal models and human genome mapping, are also studied.

Endophenotypes Of Psychiatric And Neurodegenerative Disorders In Rodent Models

Endophenotypes Of Psychiatric And Neurodegenerative Disorders In Rodent Models Book
Author : Sylvie Granon
Publisher : Unknown
Release : 2009-01-01
ISBN : 9788178954028
Language : En, Es, Fr & De

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Book Description :

Psychiatric disorders are uniquely human. Yet we need animal models to test hypotheses about biological mechanisms. Treatment development relies on model systems to evaluate the efficacy of therapeutics. How can such a profound paradox be resolved? Dr. Sylvie Granon of the Institute Pasteur in Paris has successfully assembled a collection of fifteen review chapters that address multiple aspects of rodent models of neuropsychiatric disorders. Outstanding experts describe paradigms relevant to Alzheimer s disease, mental retardation, schizophrenia, autism, attentional deficit hyperactivity disorder, impulsivity, drug addiction, post-traumatic stress disorder, multiple sclerosis, and sudden infant death syndrome. Traditional lesioning and pharmacological methods are contrasted with newer targeted gene mutation strategies for generating rodent models. Strengths and limitations of transgenic and knockout mouse models are discussed by many of the insightful authors. In Alice in Wonderland, the Cheshire Cat speaks English and tell us We re all mad here. Unfortunately, real animals do not talk, and cannot tell us about their abnormal internal emotional or mental states, if any. It is essential to recognize that researchers will never be able to replicate schizophrenia or autism or depression in a mouse. Many psychiatric dysfunctions appear to originate primarily in the human frontal cerebral cortex, a highly developed structure that dramatically eclipses the modest frontal cortex of rodents. Numbers of synapses and available pathways for making neural connections that permit higher executive functions are enormously greater in humans as compared to other species. Expansion of the human prefrontal cortex is an evolutionary recent phenomenon. There has not been enough time for thorough trouble-shooting and beta-testing of its neural circuitry. No wonder so much can go so wrong. Endophenotypes offer a neat solution to our conundrum. Rather than trying to replicate the full human syndrome, specific components of behavioral symptoms and neuroanatomical abnormalities can be modeled in rodents. While mental illnesses that are primarily caused by incorrect developmental neuroanatomy or aberrant neurotransmitter pharmacology in the prefrontal cortex may be difficult to model in mice, whose prefrontal cortex is minimal, connections between frontal cortex and other brain regions such as thalamus are similar across species. Homologies between rodents and primates in frontal cortex connections and specific behavioral functions have been extensively described by Bryan Kolb. The inability of Alzheimer s patients to store new memories represents a discrete characteristic that can be paralleled in rats and mice, who store new memories using similar neurophysiological mechanisms. Schizophrenic patients display deficits in sensorimotor gating and errors in working memory. Very similar procedures and equipment are available to assay prepulse inhibition and working memory in humans, monkeys, rats, and mice. Neuropharmacological pathways mediating the biological actions of abused drugs are similar in humans and rats. Drug addicts show poor impulse control and poor decision making in tasks that are analogous to some forms of errors in the five choice serial reaction time task for rats and mice. Genetic mutations that produce synaptic dysfunctions or amyloid plaques in the human brain are inserted into the mouse genome to create mouse models of mental retardation, which are then evaluated on learning and memory tasks. Thus, a simpler focus on individual endophenotype components of a human disease permits reasonable analogies to be generated in model organisms. The ideal animal model of a human syndrome is quantitative, readily replicated across laboratories, and incorporates three types of validity. Face validity is the conceptual analogy to a human symptom or endophenotype. Some unusual social behaviors in mice offer a conceptual analogy to the first diagnostic symptom of autism, abnormal reciprocal social interactions. Construct validity employs the same cause or precipitating event in the animal model and the human disease. Inflammatory demyelination presents construct validity for a rodent model of multiple sclerosis. Predictive validity confirms the specific therapeutic response. Treatments that work in the human disease also work in the animal model. For example, antidepressants that are effective in treating post-traumatic stress disorder should effectively reverse the behavioral traits of a rat model of this syndrome. Very few animal models of neuropsychiatric diseases incorporate all three types of validity. The authors contributing to this volume explain the challenges, failures and successes of an impressively wide range of model organisms. As the true causes of mental illnesses are identified, neuroscientists and pharmaceutical researchers will design more targeted model systems with true construct validity to the etiologies of neuropsychiatric syndromes. Behavioral assays will continue to be invented and refined to optimize face validity to the endophenotypes of the human disease. Ultimately these endeavors will result in model organisms with high predictive validity and translational value, to enhance the discovery of effective cures for debilitating major mental illnesses.

Transgenic Animal Models

Transgenic Animal Models Book
Author : Anonim
Publisher : Unknown
Release : 2003
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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Pharmacological Management of Neurological and Psychiatric Disorders

Pharmacological Management of Neurological and Psychiatric Disorders Book
Author : Sam J. Enna,Joseph T. Coyle
Publisher : McGraw-Hill
Release : 1998
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

A practical, user-friendly guide for the diagnosis, management, and treatment of neurologic and psychiatric disorders. An introductory chapter covers basic neuroscience and pharmacology as they pertain to the diagnosis and treatment of central nervous system disorders. Subsequent chapters cover the full spectrum of major psychiatric and neurological conditions including schizophrenia, ADD and developmental disorders, obsessive-compulsive behavior, disorders of sleep, neuromuscular disorders, delirium and dementia, and much more. Chapter organization for each condition features a clinical description (presenting symptoms), diagnostic criteria (pathophsiology), pharmacotherapeutics, and recommended management and treatment regimens.

Kyoto University Bulletin

Kyoto University Bulletin Book
Author : Kyōto Daigaku
Publisher : Unknown
Release : 1999
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Kyoto University Bulletin book written by Kyōto Daigaku, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Comprehensive medicinal chemistry II

Comprehensive medicinal chemistry II Book
Author : John B. Taylor,D. J. Triggle
Publisher : Elsevier Science Ltd
Release : 2007
ISBN : 9780080445137
Language : En, Es, Fr & De

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Book Description :

The first edition of Comprehensive Medicinal Chemistry was published in 1990 and very well received. Comprehensive Medicinal Chemistry II is much more than a simple updating of the contents of the first edition. Completely revised and expanded, this new edition has been refocused to reflect the significant developments and changes over the past decade in genomics, proteomics, bioinformatics, combinatorial chemistry, high-throughput screening and pharmacology, and more. The content comprises the most up-to-date, authoritative and comprehensive reference text on contemporary medicinal chemistry and drug research, covering major therapeutic classes and targets, research strategy and organisation, high-throughput technologies, computer-assisted design, ADME and selected case histories. It is this coverage of the strategy, technologies, principles and applications of medicinal chemistry in a single work that will make Comprehensive Medicinal Chemistry II a unique work of reference and a single point of entry to the literature for pharmaceutical and biotechnology scientists of all disciplines and for many industry executives as well.Comprehensive Medicinal Chemistry II will be available online in 2007 via the proven platform ScienceDirect providing the user with enhanced features such as cross-referencing and dynamic linking. * Comprehensively reviews - for the first time in one single work - the strategies, technologies, principles and applications of modern medicinal chemistry * Provides a global and current perspective of today's drug discovery process and discusses the major therapeutic classes and targets * Includes a unique collection of case studies and personal assays reviewing the discovery and development of key drugs