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Modeling Neuropsychiatric Disorders In Laboratory Animals

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Modeling Neuropsychiatric Disorders in Laboratory Animals

Modeling Neuropsychiatric Disorders in Laboratory Animals Book
Author : Kurt Leroy Hoffman
Publisher : Woodhead Publishing Limited
Release : 2015-09-15
ISBN : 9780081000991
Language : En, Es, Fr & De

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Book Description :

Modeling Neuropsychiatric Disorders in Laboratory Animals serves as a guide for students and basic investigators in the fields of behavioral sciences, psychology, neuroscience, psychiatry, and other professionals interested in the use of animal models in preclinical research related to human neuropsychiatric disorders. The text focuses on the rationale and theory of using animal behavior, both pathological and normal, as a tool for understanding the neural underpinnings of neuropsychiatric disorders. Chapters contain discussions on both classical and modern views on the validation of animal models for neuropsychiatric disorders, also discussing the utility of endophenotypes in modeling neuropsychiatric disease. Subsequent chapters deal with four specific classes of disorders, including anxiety disorders, depressive disorders, obsessive-compulsive and related disorders. Final sections discuss the future for the development, validation, and use of animal models in basic and preclinical research. Focuses on the rationale and theory of using animal behavior, both pathological and normal, as a tool for understanding the neural underpinnings of neuropsychiatric disorders Serves as a guide for students and basic investigators in the fields of behavioral sciences, psychology, neuroscience, psychiatry, and other professionals Discusses specific classes of disorders, including anxiety disorders, depressive disorders, obsessive-compulsive and related disorders

Modeling Neuropsychiatric Disorders in Laboratory Animals

Modeling Neuropsychiatric Disorders in Laboratory Animals Book
Author : Kurt Leroy Hoffman
Publisher : Woodhead Publishing
Release : 2015-08-28
ISBN : 0081001061
Language : En, Es, Fr & De

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Book Description :

Modeling Neuropsychiatric Disorders in Laboratory Animals serves as a guide for students and basic investigators in the fields of behavioral sciences, psychology, neuroscience, psychiatry, and other professionals interested in the use of animal models in preclinical research related to human neuropsychiatric disorders. The text focuses on the rationale and theory of using animal behavior, both pathological and normal, as a tool for understanding the neural underpinnings of neuropsychiatric disorders. Chapters contain discussions on both classical and modern views on the validation of animal models for neuropsychiatric disorders, also discussing the utility of endophenotypes in modeling neuropsychiatric disease. Subsequent chapters deal with four specific classes of disorders, including anxiety disorders, depressive disorders, obsessive-compulsive and related disorders. Final sections discuss the future for the development, validation, and use of animal models in basic and preclinical research. Focuses on the rationale and theory of using animal behavior, both pathological and normal, as a tool for understanding the neural underpinnings of neuropsychiatric disorders Serves as a guide for students and basic investigators in the fields of behavioral sciences, psychology, neuroscience, psychiatry, and other professionals Discusses specific classes of disorders, including anxiety disorders, depressive disorders, obsessive-compulsive and related disorders

Animal and Translational Models for CNS Drug Discovery Neurological Disorders

Animal and Translational Models for CNS Drug Discovery  Neurological Disorders Book
Author : Robert A. McArthur,Franco Borsini
Publisher : Academic Press
Release : 2008-11-18
ISBN : 9780080920382
Language : En, Es, Fr & De

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Book Description :

Neurological Disorders is written for researchers in both academia and the pharmaceutical industry who use animal models in research and development of drugs for neurological disorders such as neurofibromatosis, Alzheimer’s disease, Parkinson’s disease, Huntington disease, ALS, and the epilepsies. Neurological Disorders has introductory chapters expressing the view of the role and relevance of animal models for drug discovery and development for the treatment of psychiatric disorders from the perspective of (a) academic basic neuroscientific research, (b) applied pharmaceutical drug discovery and development, and (c) issues of clinical trial design and regulatory agencies limitations. Each volume examines the rationale, use, robustness and limitations of animal models in each therapeutic area covered and discuss the use of animal models for target identification and validation. The clinical relevance of animal models is discussed in terms of major limitations in cross-species comparisons, clinical trial design of drug candidates, and how clinical trial endpoints could be improved. The aim of this series of volumes on Animal and Translational Models for CNS Drug Discovery is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery. This is the second volume in the three volume-set, Animal and Translational Models for CNS Drug Discovery 978-0-12-373861-5, which is also available for purchase individually. Clinical, academic, government and industry perspectives fostering integrated communication between principle participants at all stages of the drug discovery process Critical evaluation of animal and translational models improving transition from drug discovery and clinical development Emphasis on what results mean to the overall drug discovery process Exploration of issues in clinical trial design and conductance in each therapeutic area

Animal Models in Medicine and Biology

Animal Models in Medicine and Biology Book
Author : Eva Tvrdá,Sarat Chandra Yenisetti
Publisher : BoD – Books on Demand
Release : 2020-04-08
ISBN : 1838800115
Language : En, Es, Fr & De

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Book Description :

Thanks to animal models, our knowledge of biology and medicine has increased enormously over the past decades, leading to significant breakthroughs that have had a direct impact on the prevention, management and treatment of a wide array of diseases.This book presents a comprehensive reference that reflects the latest scientific research being done in a variety of medical and biological fields utilizing animal models. Chapters on Drosophila, rat, pig, rabbit, and other animal models reflect frontier research in neurology, psychiatry, cardiology, musculoskeletal disorders, reproduction, chronic diseases, epidemiology, and pain and inflammation management. Animal Models in Medicine and Biology offers scientists, clinicians, researchers and students invaluable insights into a wide range of issues at the forefront of medical and biological progress.

Animal Models of Neurological Disease II

Animal Models of Neurological Disease  II Book
Author : Alan A. Boulton,Glen B. Baker,Roger F. Butterworth
Publisher : Humana
Release : 2013-08-11
ISBN : 9781489943897
Language : En, Es, Fr & De

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Book Description :

to the Animal Models Volumes This and several other volumes in the Neuromethods series will describe a number of animal models of neuropsychiatric disorders. Because of increasing public concern over the ethical treatment of animals in research, we felt it incumbent upon us to include this general preface to these volumes in order to indicate why we think further - search using animals is necessary and why animal models of psychiatric disorders, in particular, are so important. We recognize that animals should only be used when suitable alternatives are not available. We think it self-e- dent, however, that humans can only be experimented upon in severely proscribed circumstances and alternative pro- dures using cell or tissue culture are inadequate in any models requiring assessments of behavioral change or of complex in vivo processes. However, when the distress, discomfort, or pain to the animals outweighs the anticipated gains for human welfare, then the research is not ethical and should not be carried out. It is imperative that each individual researcher examine his/her own research from a critical moral standpoint - fore engaging in it, taking into consideration the animals’ welfare as well as the anticipated gains. Furthermore, once a decision to proceed with research is made, it is the researcher’s responsibility to ensure that the animals’ w- fare is of prime concern in terms of appropriate housing, feeding, and maximum reduction of any uncomfortable or distressing effects of the experimental conditions, and that these conditions undergo frequent formalized monitoring.

Therapy and the Neural Network Model

Therapy and the Neural Network Model Book
Author : Theodore Wasserman,Lori Drucker Wasserman
Publisher : Springer Nature
Release : 2019-10-16
ISBN : 3030269213
Language : En, Es, Fr & De

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Book Description :

This innovative work explores integrating emerging research into how the brain processes information in applied therapeutic interventions. Typically, clinicians select therapeutic interventions based on their own training, personal experience or preference. This book aims to provide a new model, based upon the neural networks, to both understand the development of mental health issues and their persistence, and how and why to apply therapeutic interventions to impact the systems which are maintaining them. This work begins with a short and accessible overview of the neural network model, and the general aims of therapy. It elucidates components of the neural network model of learning such as reward recognition, automaticity, and memory reconsolidation, and how they apply to both general learning and new learning through the process in therapy. Next, the authors explore how the neural network model can be integrated across existing systems of therapy, including Cognitive Behavior therapy (CBT), Dialectical Behavior Therapy (DBT), third wave therapies and analytic therapies. Therapy and the Neural Network Model is an exciting resource for researchers and practitioners interested in understanding more about the applications of a neural network model for therapy and the how and why of building new mentally healthy cognitions, behaviors and emotions. Therapy and the Neural Network Model is also an essential theoretical foundation for both researchers and practitioners who wish to base their therapeutic practice on neuroscience and integrate their work with related fields such as behavioral medicine, health psychology, social work and public health.

Patterns of Parental Behavior

Patterns of Parental Behavior Book
Author : Gabriela González-Mariscal
Publisher : Springer Nature
Release : 2022-09-28
ISBN : 3030977625
Language : En, Es, Fr & De

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Book Description :

Modern neuroscience has presented new opportunities for exploring the molecular and neural mechanisms controlling specific social responses. This book reviews insights into the neural circuits underlying a particularly fascinating form of social interaction, parental behavior. This book presents a detailed review of maternal and paternal behavior of particular mammalian species. It offer neuroscientists a spectrum of specific mammals that can be used as experimental models to explore particular topics on the functions of the nervous system. It shows that results coming from the laboratory can be translated into useful information for raising mammals on the farm, and it stimulates biologists to gain insights into the underpinnings of the complex mechanisms governing mammalian behavior in the wild. It also discusses the implications of this research for human parental behavior.

The Metaphor of the Monster

The Metaphor of the Monster Book
Author : Keith Moser,Karina Zelaya
Publisher : Bloomsbury Publishing USA
Release : 2020-10-15
ISBN : 1501364340
Language : En, Es, Fr & De

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Book Description :

The Metaphor of the Monster offers fresh perspectives and a variety of disciplinary approaches to the ever-broadening field of monster studies. The eclectic group of contributors to this volume represents areas of study not generally considered under the purview of monster studies, including world literature, classical studies, philosophy, ecocriticism, animal ethics, and gender studies. Combining historical overviews with contemporary and global outlooks, this volume recontextualizes the monstrous entities that have always haunted the human imagination in the age of the Anthropocene. It also invites reflection on new forms of monstrosity in an era epitomized by an unprecedented deluge of (mis)information. Uniting researchers from varied academic backgrounds in a common effort to challenge the monstrous labels that have historically been imposed upon "the Other," this book endeavors above all to bring the monster out of the shadows and into the light of moral consideration.

Handbook of Laboratory Animal Science Volume II

Handbook of Laboratory Animal Science  Volume II Book
Author : Jann Hau,Steven J. Schapiro
Publisher : CRC Press
Release : 2011-04-22
ISBN : 1420084585
Language : En, Es, Fr & De

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Book Description :

Biomedical research involving animals remains essential for the advancement of the medical, veterinary, agricultural, and biological sciences. Following in the footsteps of its predecessors, the Handbook of Laboratory Animal Science, Volume II, Third Edition: Animal Models explains in great detail the comparative considerations underlying the choic

Handbook of Laboratory Animal Science

Handbook of Laboratory Animal Science Book
Author : Jann Hau,Steven J. Schapiro
Publisher : CRC Press
Release : 2021-05-17
ISBN : 0429801599
Language : En, Es, Fr & De

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Book Description :

Building upon the success of previous editions of the bestselling Handbook of Laboratory Animal Science, first published in 1994, this latest revision combines all three volumes in one definitive guide. It covers the essential principles and practices of Laboratory Animal Science as well as selected animal models in scientific disciplines where much progress has been made in recent years. Each individual chapter focuses on an important subdiscipline of laboratory animal science, and the chapters can be read and used as stand-alone texts, with only limited necessity to consult other chapters for information. With new contributors at the forefront of their fields, the book reflects the scientific and technological advances of the past decade. It also responds to advances in our understanding of animal behavior, emphasizing the importance of implementing the three Rs: replacing live animals with alternative methods, reducing the number of animals used, and refining techniques to minimize animal discomfort. This fourth edition will be useful all over the world as a textbook for laboratory animal science courses for postgraduate and undergraduate students and as a handbook for scientists who work with animals in their research, for university veterinarians, and for other specialists in laboratory animal science.

Animal Models in Psychiatry I

Animal Models in Psychiatry  I Book
Author : Alan A. Boulton,Glen B. Baker,Mathew T. Martin-Iverson
Publisher : Springer Science & Business Media
Release : 1991-08-20
ISBN : 0896031985
Language : En, Es, Fr & De

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Book Description :

The two Animal Models in Psychiatry volumes are loosely organized by subject. The first volume contains a number of chapters concerned with schizophrenia, psyc- ses, neuroleptic-induced tardive dyskinesias, and other d- orders that may involve dopamine, such as attention deficit disorder and mania. The second volume deals with affective and anxiety disorders, but also includes chapters on subjects not easily classified as either psychotic, or affective, or an- ety-related, such as aggression, mental retardation, and memory disorders. Four chapters on animal models of schizophrenia or psychoses are included in the present v- ume because of the importance of these disorders in p- chiatry. Likewise, three chapters in the subsequent volume deal with depression. The first of the two volumes begins with an introd- tion by Paul Willner reviewing the criteria for assessing the validity of animal models in psychiatry. He has written - tensively on this subject, and his thorough description of the issues of various forms of validity provides a framework in which to evaluate the subsequent chapters. As will be seen, the remaining chapters in both volumes will refer frequently to these issues. The second chapter, by Melvin Lyon, describes a large number of different procedures that have been p- posed as potential animal models of schizophrenia. This is a departure from the usual format, consisting of detailed - scriptions of specific models.

Translational Neuroimaging

Translational Neuroimaging Book
Author : Robert A. McArthur
Publisher : Academic Press
Release : 2012-10-26
ISBN : 0123869455
Language : En, Es, Fr & De

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Book Description :

With a unique collaborative approach of author teams from industry and academia, Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment provides an integrated perspective of small animal and human brain imaging in the development of translational models and biomarkers to understand human neuropsychiatric disorders and to accelerate the development of novel drugs for their treatment. The book provides chapters on methodical issues in human and animal neuroimaging translational research, allowing a beginning researcher or researcher outside of his/her expertise the opportunity to understand the background of translational research and the use of imaging in studies. Additional chapters cover selected neuropsychiatric disorders, examining the role of neuroimaging in translational model development from the preclinical, animal model perspective as well as from the human experimental medicine perspective. Offering an accompanying website with illustrations and text available for further knowledge and presentations, Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment appeals to researchers working in and studying CNS drug treatment research across industry and academia. Provides a background of translational research and the use of imaging in studies Dicusses the application of imaging in specific disease states Features an accompanying website with additional images and text

Handbook of Medical Psychiatry

Handbook of Medical Psychiatry Book
Author : Jair C. Soares,Samuel Gershon
Publisher : CRC Press
Release : 2003-03-19
ISBN : 0203912489
Language : En, Es, Fr & De

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Book Description :

This volume examines attempts to identify genetic risk factors and environmental components contributing to the development of psychiatric disorders. It explores the symptoms, courses, outcomes, treatment responses and aetiologies of a range of psychiatric illnesses to improve disease classification schemes.

Translational Research Methods in Neurodevelopmental Disorders

Translational Research Methods in Neurodevelopmental Disorders Book
Author : Stéphane Martin,Frédéric Laumonnier
Publisher : Springer Nature
Release : 2022-09-29
ISBN : 1071625691
Language : En, Es, Fr & De

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Book Description :

This volume explores the latest techniques used to study neurodevelopmental diseases (NDD) that range from molecular aspects to integrated research approaches and brain imaging in living rodents. Chapters in this book cover topics such as protocols to deliver shRNA in vitro and in vivo using lentiviral particles to knock-down specific protein expression; experimental procedures to use recombinant fluorescent probes to visualize endogenous proteins at the mammalian synapse; CRISPR/Cas9 toolkit to assess either gain- or loss-of-gene function in brain organoids; detailed protocols to use in vivo manipulations to correct the behavioral phenotypes in cognitive disorder mouse lines; and experimental approaches to genetically engineer macaque models of NDDs and investigate how genetic predisposition may cause neural and functional alterations. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and practical, Translational Research Methods in Neurodevelopmental Disorders is a valuable resource for all researchers who want to learn more about this important and developing field.

Glutamate and Neuropsychiatric Disorders

Glutamate and Neuropsychiatric Disorders Book
Author : Zoran M. Pavlovic
Publisher : Springer Nature
Release : 2022-04-10
ISBN : 303087480X
Language : En, Es, Fr & De

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Book Description :

This volume provides a comprehensive overview of recent advances in targeting glutamate signaling for the treatment of major psychiatric and neurological disorders. It draws on the latest findings in glutamate neurobiology and offers valuable insights into the application of translational principles in neuroscience drug discovery and development. In each chapter, glutamate as a neurotransmitter, its receptors and transporters, and their interplay with other neurotransmitters and neurotrophic factors, are discussed in the context of a specific, highly prevalent and disabling CNS disease. Most recent and detailed information is provided on Ischemic Stroke, Chronic Stress, Major Depressive Disorder, Bipolar Disorder, Autism Spectrum Disorders (ASD), Posttraumatic Stress Disorder (PTSD), Alzheimer’s Dementia, Schizophrenia, Impulsive Aggression, Substance Use Disorders (SUD), Amyotrophic Lateral Sclerosis (ALS), Chronic Pain, Multiple Sclerosis, Parkinson’s Disease, Attention Deficit Hyperactivity Disorder (ADHD), Migraine, Epilepsy and Anxiety disorders. Moreover, the book includes an extensive overview of glutamatergic treatments already available on the market, and those which are currently in pharmaceutical drug development pipelines. The primary beneficiaries will be neurology and psychiatry specialists and residents, neuroscientists, neuropharmacologists, pharmaceutical industry and clinical research organization professionals, academics, and clinicians working with psychiatric and neurological patients with comorbidities such as cardiologists, pulmonologists, and endocrinologists. This book will also appeal to psychiatry and neurology subspecialists and clinicians working in neuroscience labs seeking an easy-to-understand yet comprehensive overview of contemporary evidence-based clinical insights backed by basic science (preclinical) research evidence. Given its scope, the book is also a unique and indispensable resource for both preclinical and clinical neuroscientists, medical advisors, and clinical research specialists in the pharmaceutical industry. In addition, it will appeal to neuroscience and neuropsychopharmacology students and guide them through the complexities of glutamate involvement in the pathophysiology of the most common debilitating brain diseases with high unmet medical needs.

Psychiatric Vulnerability Mood and Anxiety Disorders

Psychiatric Vulnerability  Mood  and Anxiety Disorders Book
Author : Jaanus Harro
Publisher : Springer Nature
Release : 2022-09-30
ISBN : 1071627481
Language : En, Es, Fr & De

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Book Description :

This volume looks at classic and novel methods currently used by researchers to understand mood and anxiety disorders and foster precision medicine. Chapters in this book cover topics such as how the sucrose preference succeeds or fails as a measurement of anhedonia; fear conditioning in laboratory rodents; animal models for mania; rodent models for studying the impact of variation in early life mother-infant interactions on mood and anxiety; and prediction of susceptibility/resilience toward animal models of PTSD. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Comprehensive and cutting-edge, accommodating the novel views on how the neurobiology of psychiatric disorders should be reconceptualized, Psychiatric Vulnerability, Mood, and Anxiety Disorders: Tests and Models in Mice and Rats is a valuable resource for all researchers interested in learning more about this important and developing field.

Psychiatry

Psychiatry Book
Author : Allan Tasman,Jerald Kay,Jeffrey A. Lieberman,Michael B. First,Michelle Riba
Publisher : John Wiley & Sons
Release : 2015-01-29
ISBN : 1118845498
Language : En, Es, Fr & De

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Book Description :

Now in a new Fourth Edition, Psychiatry remains the leading reference on all aspects of the current practice and latest developments in psychiatry. From an international team of recognised expert editors and contributors, Psychiatry provides a truly comprehensive overview of the entire field of psychiatry in 132 chapters across two volumes. It includes two new sections, on psychosomatic medicine and collaborative care, and on emergency psychiatry, and compares Diagnostic and Statistical Manual (DSM-5) and International Classification of Diseases (ICD10) classifications for every psychiatric disorder. Psychiatry, Fourth Edition is an essential reference for psychiatrists in clinical practice and clinical research, residents in training, and for all those involved in the treatment psychiatric disorders. Includes a a companion website at www.tasmanpsychiatry.com featuring PDFs of each chapter and downloadable images

The Endocannabinoid System Filling the Translational Gap between Neuroscience and Psychiatry

The Endocannabinoid System  Filling the Translational Gap between Neuroscience and Psychiatry Book
Author : Marco Colizzi,Sagnik Bhattacharyya,Danilo De Gregorio,Mirella Ruggeri
Publisher : Frontiers Media SA
Release : 2022-01-24
ISBN : 2889741486
Language : En, Es, Fr & De

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Book Description :

Download The Endocannabinoid System Filling the Translational Gap between Neuroscience and Psychiatry book written by Marco Colizzi,Sagnik Bhattacharyya,Danilo De Gregorio,Mirella Ruggeri, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Psychiatry 2 Volume Set

Psychiatry  2 Volume Set Book
Author : Allan Tasman,Jerald Kay,Jeffrey A. Lieberman,Michael B. First,Michelle Riba
Publisher : John Wiley & Sons
Release : 2015-03-30
ISBN : 1118845471
Language : En, Es, Fr & De

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Book Description :

Now in a new Fourth Edition, Psychiatry remains the leading reference on all aspects of the current practice and latest developments in psychiatry. From an international team of recognised expert editors and contributors, Psychiatry provides a truly comprehensive overview of the entire field of psychiatry in 132 chapters across two volumes. It includes two new sections, on psychosomatic medicine and collaborative care, and on emergency psychiatry, and compares Diagnostic and Statistical Manual (DSM-5) and International Classification of Diseases (ICD10) classifications for every psychiatric disorder. Psychiatry, Fourth Edition is an essential reference for psychiatrists in clinical practice and clinical research, residents in training, and for all those involved in the treatment psychiatric disorders. Includes a a companion website at www.tasmanpsychiatry.com featuring PDFs of each chapter and downloadable images

Experimental Animal Models in Neurobehavioral Research

Experimental Animal Models in Neurobehavioral Research Book
Author : Allan V. Kalueff
Publisher : Nova Science Pub Incorporated
Release : 2009
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Behavioural research has been an exciting staple of the neuroscientific community's efforts in combating the rising challenges of mental healthcare. New innovations are bringing a greater understanding of the pathogenic mechanisms behind the disorders and allowing for progress towards their remedies. this translational approach, using newly developed animal modes, is of critical importance for the study of neuropsychiatric disorders. While the differences between the subjects of clinical research and basic research are obvious, there are many neurobiological similarities that allow for the possibility of creating an accurate animal analogue of a human disorder. These tools contribute to translational research and are the best hope for countering the challenges facing the field of mental health. This book provides chapters on a range of issues in biopsychology and behavioural neuroscience. It offers innovative methodological and conceptual advances regarding topics such as sleep, depression, and anxiety, as well as how these domains interact. All authors of the book are recognised experts in the field, and have written their chapters for an international audience of basic and clinical neuroscientists who are interested in behavioural neurophenotyping. The writing will also be accessible to students at the undergraduate level, while still providing an important update to graduate students and professional researchers in the disciplines of psychology, biology, and neuroscience on this rapidly developing field.