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Mitochondrial Metabolism An Approach For Disease Management

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Mitochondrial Metabolism

Mitochondrial Metabolism Book
Author : Jalal Pourahmad,Mohsen Rezaei
Publisher : Academic Press
Release : 2021-08-09
ISBN : 0128224096
Language : En, Es, Fr & De

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Book Description :

Mitochondrial Metabolism: An Approach for Disease Management covers mitotherapy from three combined perspectives, Pharmacology, Toxicology and Biochemistry. After an introduction from world-renowned experts, the book's chapters cover the balancing role in reduction/oxidation mitochondria play, mitochondria as targets for therapeutics through its metabolism, mitochondrial contributions to the cell death process, mitochondrial response to environmental toxicants, the mitochondrial role in aging, the impact of calorie restrictive diets, new advances in the identification of altered mitochondria associated signaling pathways in carcinogenesis, and much more. This book provides bioscientists new horizons to realize the importance of mitochondria in present-day research on therapies dealing with mitochondria associated chronic diseases, including diabetes, cancer and neurodegenerative disorders. Details the significant role of mitochondria in chronic diseases Presents new insights on the targeting of mitochondria for therapeutic purposes Includes updated results on mitotherapy and other mitochondria-oriented therapies

Mitochondrial Metabolism

Mitochondrial Metabolism Book
Author : Jalal Pourahmad,Mohsen Rezaei
Publisher : Elsevier
Release : 2021-08-23
ISBN : 0128224169
Language : En, Es, Fr & De

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Book Description :

Mitochondrial Metabolism: An Approach for Disease Management covers mitotherapy from three combined perspectives, Pharmacology, Toxicology and Biochemistry. After an introduction from world-renowned experts, the book's chapters cover the balancing role in reduction/oxidation mitochondria play, mitochondria as targets for therapeutics through its metabolism, mitochondrial contributions to the cell death process, mitochondrial response to environmental toxicants, the mitochondrial role in aging, the impact of calorie restrictive diets, new advances in the identification of altered mitochondria associated signaling pathways in carcinogenesis, and much more. This book provides bioscientists new horizons to realize the importance of mitochondria in present-day research on therapies dealing with mitochondria associated chronic diseases, including diabetes, cancer and neurodegenerative disorders. Details the significant role of mitochondria in chronic diseases Presents new insights on the targeting of mitochondria for therapeutic purposes Includes updated results on mitotherapy and other mitochondria-oriented therapies

Mitochondria in Obesity and Type 2 Diabetes

Mitochondria in Obesity and Type 2 Diabetes Book
Author : Beatrice Morio,Luc Penicaud,Michel Rigoulet
Publisher : Academic Press
Release : 2019-04-15
ISBN : 0128117524
Language : En, Es, Fr & De

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Book Description :

Mitochondria in Obesity and Type 2 Diabetes: Comprehensive Review on Mitochondrial Functioning and Involvement in Metabolic Diseases synthesizes discoveries from laboratories around the world, enhancing our understanding of the involvement of mitochondria in the etiology of diseases, such as obesity and type 2 diabetes. Chapters illustrate and provide an overview of key concepts on topics such as the role of mitochondria in adipose tissue, cancer, cardiovascular comorbidities, skeletal muscle, the liver, kidney, and more. This book is a must-have reference for students and educational teams in biology, physiology and medicine, and researchers. Synthesizes actual knowledge on mitochondrial function Provides an integrated vision of each tissue in the etiology of obesity and type 2 diabetes Identifies the interactive networks that involve alteration in mitochondrial mass and function in disease progression Highlights the role played by mitochondria in the prevention and treatment of obesity and type 2 diabetes

Oxidative Stress in Lung Diseases

Oxidative Stress in Lung Diseases Book
Author : Sajal Chakraborti,Narasimham L. Parinandi,Rita Ghosh,Nirmal K. Ganguly,Tapati Chakraborti
Publisher : Springer Nature
Release : 2019-11-23
ISBN : 9813293667
Language : En, Es, Fr & De

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Book Description :

This is the second volume of the comprehensive, two-volume work on oxidative stress in lung diseases. Adopting a multidisciplinary approach, it demonstrates the cellular and molecular mechanisms associated with ROS (reactive oxygen species)-induced initiation and progression of a variety of lung diseases, such as COPD, emphysema, asthma, cystic fibrosis, occupational pulmonary diseases and pulmonary hypertension and discusses points for therapeutic intervention. The book also covers translational research and the latest research on prevention and therapeutics. Each chapter includes in-depth insights into the mechanisms associated with lung diseases and into identifying targets for drug development. Bridging the gap between fundamental and translational research, and examining applications in the biomedical and pharmaceutical industry, it is a thought- provoking read for basic and applied scientists engaged in biomedical research.

Inborn Errors of Metabolism

Inborn Errors of Metabolism Book
Author : Brendan Lee MD, PhD,Fernando Scaglia MD
Publisher : Oxford University Press
Release : 2014-10-01
ISBN : 0199797684
Language : En, Es, Fr & De

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Book Description :

Texts on inborn errors of metabolism (IEMs) have traditionally focused on classical biochemistry, clinical presentation, and standard treatment approaches. Inborn Errors of Metabolism is an expansion on this model, one that establishes an innovative pathway approach and provides a new authority on this family of disease. Alongside the standard cadre of molecular and clinical underpinnings, this volume includes coverage of newborn screenings and an overarching treatment of IEMs as complex diseases -- how basic alterations can lead to complex secondary and tertiary effects in metabolism that contribute to increasingly recognized natural histories of disease.

Inborn Metabolic Diseases

Inborn Metabolic Diseases Book
Author : Jean-Marie Saudubray,Georges van den Berghe,John H. Walter
Publisher : Springer Science & Business Media
Release : 2011-11-16
ISBN : 3642157203
Language : En, Es, Fr & De

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Book Description :

Being up to Date: Status Quo and Trends of Treatment For those involved in the identification and management of patients with inborn errors of metabolism, this book is now recognised as the standard textbook in this interdisciplinary field. It has proved to be indispensable for professionals in specialities ranging from pediatrics, neonatology, pathological biochemistry and genetics to neurology, internal medicine, nursing, dietetics and psychology. This 5th edition has been extensively revised and updated. What ́s new - Additional chapter focusing on inborn errors affecting adults, particularly the late neurological presentations - Numerous updates on diagnostic procedures and treatment - Newly discovered disorders. As with previous editions, the book opens with a section presenting the clinical approach to inborn metabolic diseases for those cases in which a diagnosis is being sought. This now includes a chapter on the clinical presentation of metabolic diseases in the older age range, using an analogous structure. If a particular diagnosis is already suspected, the reader may refer to the following sections of the book containing general chapters on diagnostic procedures and treatment, and on specific groups of disorders. As with earlier editions, the chapters have been written by authors who are internationally recognised experts on their subjects. They provide information in a clear, relevant and concise manner using a coherent structure.

Mitochondrial Physiology and Vegetal Molecules

Mitochondrial Physiology and Vegetal Molecules Book
Author : Marcos Roberto de Oliveira
Publisher : Academic Press
Release : 2021-07-14
ISBN : 0128215836
Language : En, Es, Fr & De

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Book Description :

Mitochondrial Physiology and Vegetal Molecules: Therapeutic potential of natural compounds on mitochondrial health provides a comprehensive overview of mitochondrial physiology throughout the human life span, as well as the effect of molecules of vegetal origin on mitochondrial health. The editor has lined up a team of worldwide experts to cover the most exciting and high-impact advancements of research in this area. This book is structured into two parts that provide a balance of both foundational and applied content. Part I provides an overview of mitochondrial physiology including its structure, dynamics, biogenesis, membranes, DNA transcription, and translation in the mitochondria. Part I also covers other themes such as apoptosis. Part II then covers the effect of specific vegetable-derived molecules on mitochondrial health, including anthocyanins, caffeine, cannabinoids, carnosic and rosmarinic acids, citrus flavonoids, polyphenols, pterostilbene, resveratrol, and sulforaphane, among others. Mitochondrial Physiology and Vegetal Molecules: Therapeutic potential of natural compounds on mitochondrial health is a complete resource for researchers in this exciting field. Its comprehensive coverage makes it particularly interesting to bioscience researchers willing to understand the foundations of mitochondrial physiology throughout the human life span. Clinician researchers, MDs, nutritionists, pharmacologists, and sports scientists may be attracted to the detailed information on the health effects of vegetal origin molecules on the organelle. Contains detailed information on plant products and their effect on mitochondria Proposes therapies and reviews mechanisms of absorption at the cellular level Discusses the limited bioavailability of plant molecules/compounds in the human organism Includes coverage of specific conditions such as Sports and affective disorders, among others Presents the protective effects of plant products in mitochondrial health through all stages of life

Cancer as a Metabolic Disease

Cancer as a Metabolic Disease Book
Author : Thomas Seyfried
Publisher : John Wiley & Sons
Release : 2012-06-26
ISBN : 0470584920
Language : En, Es, Fr & De

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Book Description :

The book addresses controversies related to the origins of cancer and provides solutions to cancer management and prevention. It expands upon Otto Warburg's well-known theory that all cancer is a disease of energy metabolism. However, Warburg did not link his theory to the "hallmarks of cancer" and thus his theory was discredited. This book aims to provide evidence, through case studies, that cancer is primarily a metabolic disease requring metabolic solutions for its management and prevention. Support for this position is derived from critical assessment of current cancer theories. Brain cancer case studies are presented as a proof of principle for metabolic solutions to disease management, but similarities are drawn to other types of cancer, including breast and colon, due to the same cellular mutations that they demonstrate.

A Practical Approach to Movement Disorders

A Practical Approach to Movement Disorders Book
Author : Dr. Hubert Fernandez, MD,Ramon L. Rodriguez, MD,Frank M. Skidmore, MD,Michael Okun, MD
Publisher : Demos Medical Publishing
Release : 2007-06-14
ISBN : 1933864141
Language : En, Es, Fr & De

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Book Description :

"This book provides the busy clinician with a quick, symptom-based guide to the clinical presentation, diagnosis, work-up, and management of the most common types of movement disorders encountered in clinical practice, including Parkinson's disease, chorea, dystonia, myoclonus, and ataxia. Written in expanded outline format, with frequent diagnostic and therapeutic algorithms, tables, and scales, it is an essential guide for clinicians faced with patients with movement disorders. A Practical Approach to Movement Disorders is a welcome departure from the typical lengthy, disease-based hardbound texts ill suited for the busy clinician. Practical yet authoritative, this fit-in-your-coat-pocket guide begins with a comprehensive description of the different presentations of movement disorders. It then details the medical, surgical, and non-pharmacological approaches, including speech and swallowing therapy and physical and occupational therapy. Key features include: Symptom-based, rather than disease-based, chapters A focus on the most common movement disorders A unique section on the neurological aspects of deep brain stimulation (DBS) Dozens of diagnostic and management pearls Suggested readings for each chapter Handy and comprehensive, A Practical Approach to Movement Disorders is the only guide for busy clinicians needing quick information on movement disorders."

Diagnosis and Management of Mitochondrial Disorders

Diagnosis and Management of Mitochondrial Disorders Book
Author : Michelangelo Mancuso,Thomas Klopstock
Publisher : Springer
Release : 2019-05-03
ISBN : 3030055175
Language : En, Es, Fr & De

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Book Description :

This book will help readers navigate the complexity of mitochondrial disorders, by addressing the role of mitochondrial dysfunction and the complex pathophysiological mechanisms associated with a growing number of illnesses, not only of neurological interest. Further, it provides updated concepts on genotype-phenotype correlations, clinical syndromes, diagnostic algorithms and therapies. Written by the world’s foremost mitochondrial researchers, the book comprehensively presents the state-of-the-art in mitochondrial medicine, making it of interest to a wide variety of specialists, including neurologists, geneticists, internists and biologists.

Systems Analysis of Energy Metabolism Elucidates the Roles of Mitochondria in Human Health and Disease

Systems Analysis of Energy Metabolism Elucidates the Roles of Mitochondria in Human Health and Disease Book
Author : Thuy D. Vo
Publisher : Unknown
Release : 2007
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Beginning as the science of life, biology has been transformed and expanded throughout the years to give rise to fields such as ecology, molecular biology, biophysics, and biochemistry. The distinction among these disciplines is perhaps artificial as the study of any particular biological process or system often spans multiple fields. The research on energy metabolism to follow involves three fields: bioinformatics, bioengineering, and systems biology. The informatics aspect deals with the mining, organization, and management of genomic, proteomic, microarray and biochemical data for reconstructing metabolic networks. The engineering aspect employs the application of mathematics and scientific fundamentals to construct constraint-based models for examination. The systems biology paradigm allows the analysis and interpretation of the models and data from a holistic perspective. Specifically, the findings of this work center on energy metabolism as understood by resource allocation and roles or mitochondria in mammalian cells in health and diseased states. The constraint-based framework provides the facilities for biological discovery using tools from the three mentioned disciplines. This modeling approach describes a biological system as a network of components whose behaviors can be predicted upon the application of constraints. Energy metabolism of four systems - mitochondria, cardiomyocytes, hepatocytes, and fibroblasts - is investigated here. The application of linear constraints on metabolite mass, reaction reversibility and substrate utilization allows an exploration of network capability and topology. The capability and topology of the mitochondrial metabolic network are evaluated based on the theoretical energetic yield of substrates, the number of alternate pathways satisfying the same metabolic objective, and the effects of diabetic and ischemic conditions on feasible steady states. The second part of this dissertation involves the use of stable isotopes to uncover physiological steady states assumed by the cell. Nonlinear constraints are used to balance isotopomers and select for a set of flux distributions that match GC-MS data. Results from studies with cardiomyocytes and hepatocytes elucidate the paths undertaken by substrates as well as effects of media composition on intracellular flux distributions. Most significantly, results from tissue culture study identify complex II as the deficient complex in fibroblasts derived from a patient affected with Leigh's disease.

Anderson s Pediatric Cardiology E Book

Anderson   s Pediatric Cardiology E Book Book
Author : Robert H. Anderson,Kumar Krishna,Kathleen A. Mussato,Andrew Redington,James S. Tweddell,Justin Tretter
Publisher : Elsevier Health Sciences
Release : 2019-04-29
ISBN : 0702079243
Language : En, Es, Fr & De

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Book Description :

As a leading reference on pediatric cardiology and congenital heart disease, Anderson's Pediatric Cardiology provides exhaustive coverage of potential pediatric cardiovascular anomalies, potential sequelae related to these anomalies, comorbidities and neurodevelopmental problems, and current methods for management and treatment. The fully revised 4th Edition addresses significant and ongoing changes in practice, including recent developments in fetal, neonatal, and adult congenital heart conditions as well as expanded content on intensive care, nursing issues, and societal implications. The outstanding illustration program provides superb visual guidance, and is now supplemented with a remarkable collection of more than 200 professionally curated, author-narrated videos. Offers authoritative, long-term coverage of a broad spectrum of cardiology conditions ranging from fetal development to age 21, including congenital heart disease, adult congenital heart disease (ACHD), acquired heart disease, cardiomyopathies, and rhythm disturbances. Features exceptionally detailed and original drawings by Dr. Robert Anderson and Diane Spicer, including over 850 anatomic, photographic, imaging, and algorithmic figures, and incorporating new images using virtual dissections of 3D datasets obtained in living patients. Contains new chapters on quality improvement in congenital heart disease, models of care delivery, neurocognitive assessment and outcomes, psychosocial issues for patients and families, ethics, nursing implications, acute and chronic renal complications, and telemedicine. Offers a completely new section on fetal imaging and management. Provides a new focus on patient and family-centered care with expert advice on how to communicate difficult diagnoses to patients and families. Features new integration of nursing content into all disease-specific chapters, as well as updated content on genetics, congenital heart disease and follow-up, and new imaging modalities. Contains chapters on new and emerging topics such as MRI and Quantifying the Fetal Circulation in Congenital Cardiac Disease; Congenital Anomalies of the Coronary Arteries; and The Global Burden of Pediatric Heart Disease and Pediatric Cardiac Care in Low- and Middle-Income Countries. Shares the experience and knowledge of an international team of multidisciplinary experts in medicine and advanced practice nursing.

Food and Nutrients in Disease Management

Food and Nutrients in Disease Management Book
Author : Ingrid Kohlstadt
Publisher : CRC Press
Release : 2016-04-19
ISBN : 9781420067637
Language : En, Es, Fr & De

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Book Description :

Food and nutrients are the original medicine and the shoulders on which modern medicine stands. But in recent decades, food and medicine have taken divergent paths and the natural healing properties of food have been diminished in the wake of modern technical progress. With contributions from highly regarded experts who work on the frontlines of di

Inborn Metabolic Diseases

Inborn Metabolic Diseases Book
Author : Jean-Marie Saudubray,Matthias R. Baumgartner,Angeles García-Cazorla,John H. Walter
Publisher : Springer
Release : 2021-08-12
ISBN : 9783662631225
Language : En, Es, Fr & De

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Book Description :

This 7th edition is a milestone in the series of Inborn Metabolic Diseases (IMD), recognised as the standard textbook for professionals involved in the diagnosis and management of IMD. Within the last 5 years a Copernican revolution in our understanding of IMD has changed the definition, concepts, paradigms, and classification. This new edition now extends the concept of IMD to include those disturbances in molecular machinery diagnosed by molecular techniques but currently without measurable metabolic markers. The book presents a clinical and biochemical approach to the diagnosis and management of IEM with many diagnostic algorithms for patients of all ages and with a particular focus on neurological presentations. It includes separate, comprehensive sections on IEM classified in 3 major pathophysiological categories: disorders of energy metabolism, both mitochondrial and non-mitochondrial; small molecule disorders, mostly diagnosed with metabolic markers; and complex molecules disorders, mostly diagnosed with molecular techniques. Two new chapters were added, describing around 600 disorders of nucleic acid metabolism, tRNA metabolism, ribosomal biogenesis, and cellular trafficking.

Mitochondria in Obesity and Type 2 Diabetes

Mitochondria in Obesity and Type 2 Diabetes Book
Author : Beatrice Morio,Luc Penicaud,Michel Rigoulet
Publisher : Academic Press
Release : 2019-04-13
ISBN : 0128118598
Language : En, Es, Fr & De

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Book Description :

Mitochondria in Obesity and Type 2 Diabetes: Comprehensive Review on Mitochondrial Functioning and Involvement in Metabolic Diseases synthesizes discoveries from laboratories around the world, enhancing our understanding of the involvement of mitochondria in the etiology of diseases, such as obesity and type 2 diabetes. Chapters illustrate and provide an overview of key concepts on topics such as the role of mitochondria in adipose tissue, cancer, cardiovascular comorbidities, skeletal muscle, the liver, kidney, and more. This book is a must-have reference for students and educational teams in biology, physiology and medicine, and researchers. Synthesizes actual knowledge on mitochondrial function Provides an integrated vision of each tissue in the etiology of obesity and type 2 diabetes Identifies the interactive networks that involve alteration in mitochondrial mass and function in disease progression Highlights the role played by mitochondria in the prevention and treatment of obesity and type 2 diabetes

Cumulated Index Medicus

Cumulated Index Medicus Book
Author : Anonim
Publisher : Unknown
Release : 1995
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Cumulated Index Medicus book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Principles of Perinatal Neonatal Metabolism

Principles of Perinatal Neonatal Metabolism Book
Author : Richard M. Cowett
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 1461216427
Language : En, Es, Fr & De

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Book Description :

Here, a stellar international group of contributors examines the various aspects of metabolism in the human adult during pregnancy, in the foetus, and in the new-born. This second edition has been completely updated and now has more than 17 new chapters. Divided into five sections, the book contains discussions of methodologies using molecular biology techniques, expanded coverage of central nervous system metabolism, and an entirely new section on organ-specific metabolism organised according to each organ-system. A must for every physician who cares for the pregnant patient and her child.

Genetics Diagnosis Inborn Errors of Metabolism and Newborn Screening An Update An Issue of Clinics in Perinatology

Genetics Diagnosis  Inborn Errors of Metabolism and Newborn Screening  An Update  An Issue of Clinics in Perinatology  Book
Author : Michael J. Gambello
Publisher : Elsevier Health Sciences
Release : 2015-08-12
ISBN : 0323356850
Language : En, Es, Fr & De

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Book Description :

Genetic testing and genome sequencing have opened up the possibility to clinicians and families to treat diseases, syndromes, and malformations earlier and provide therapeutic interventions.The guest editors seek to provide a basic overview of the topic for the neonatologist/perinatologist. Articles addres dysmorphology, syndromes in the infant, skeletal dysplasias, limb malformations, craniofacial anomolies, GI/liver disease, disorders of sexual develoment, brain defects, inborn errors of metabolism, and congenital heart disease.

Pediatric and Adult Nutrition in Chronic Diseases Developmental Disabilities and Hereditary Metabolic Disorders

Pediatric and Adult Nutrition in Chronic Diseases  Developmental Disabilities  and Hereditary Metabolic Disorders Book
Author : Shirley W. Ekvall,Valli K. Ekvall
Publisher : Oxford University Press
Release : 2017-03-15
ISBN : 0199398917
Language : En, Es, Fr & De

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Book Description :

"Packed with information that is useful on a daily basis. This book will be useful for all who care for children with disabilities or chronic disase." --Journal of Parental and Enteral Nutrition Food and nutrition studies are more relevant to the practice of medicine than ever before. As scientific understanding of these links has expanded over the last decade, the need for an authoritative reference has never been greater. This fully revised and updated edition of PEDIATRIC AND ADULT NUTRITION IN CHRONIC DISEASES, DEVELOPMENTAL DISABILITIES, AND HEREDITARY METABOLIC DISORDERS offers a comprehensive reference to the nutritional interventions for diseases across the lifespan. Comprising more than 60 topic-based chapters from leading figures in nutrition and medicine, this book is the most up-to-date work on diet as a symptom of, and therapy for, chronic, hereditary, and developmental disorders. Enriched with tables and charts that distill the latest recommendations for nutrient intake, physical activity, this third edition is a convenient and essential resource for busy clinicians and students in nutrition, dietetics, and medical specialties.

Disorders of Voluntary Muscle

Disorders of Voluntary Muscle Book
Author : George Karpati
Publisher : Cambridge University Press
Release : 2010-01-21
ISBN : 110737734X
Language : En, Es, Fr & De

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Book Description :

This major new edition fulfils the need for a single-volume, up-to-date information resource on the etiology, pathogenesis, diagnosis and treatment of diseases of skeletal muscles, including the muscular dystrophies, mitochondrial myopathies, metabolic myopathies, ion channel disorders, and dysimmune myopathies. As background to the clinical coverage, relevant information on advances in molecular and developmental biology, immunopathology, mitochondrial biology, ion-channel dynamics, cell membrane and signal transduction science, and imaging technology is summarized. Combining essential new knowledge with the fundamentals of history-taking and clinical examination, this extensively illustrated book will continue to be the mainstay for practising physicians and biomedical scientists concerned with muscle disease. Regular updates on the clinical and basic science aspects of muscle disease - written mainly by rising stars of myology - will be published on an accompanying website.