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Mitochondrial Metabolism An Approach For Disease Management

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Mitochondrial Metabolism

Mitochondrial Metabolism Book
Author : Jalal Pourahmad,Mohsen Rezaei
Publisher : Academic Press
Release : 2021-07-28
ISBN : 0128224096
Language : En, Es, Fr & De

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Book Description :

Mitochondrial Metabolism: An Approach for Disease Management covers mitotherapy from three combined perspectives, Pharmacology, Toxicology and Biochemistry. After an introduction from world-renowned experts, the book's chapters cover the balancing role in reduction/oxidation mitochondria play, mitochondria as targets for therapeutics through its metabolism, mitochondrial contributions to the cell death process, mitochondrial response to environmental toxicants, the mitochondrial role in aging, the impact of calorie restrictive diets, new advances in the identification of altered mitochondria associated signaling pathways in carcinogenesis, and much more. This book provides bioscientists new horizons to realize the importance of mitochondria in present-day research on therapies dealing with mitochondria associated chronic diseases, including diabetes, cancer and neurodegenerative disorders. Details the significant role of mitochondria in chronic diseases Presents new insights on the targeting of mitochondria for therapeutic purposes Includes updated results on mitotherapy and other mitochondria-oriented therapies

Mitochondrial Dynamics in Cardiovascular Medicine

Mitochondrial Dynamics in Cardiovascular Medicine Book
Author : Gaetano Santulli
Publisher : Springer
Release : 2017-05-25
ISBN : 3319553305
Language : En, Es, Fr & De

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Book Description :

This text covers the basic principles of mitochondrial dynamics in cardiovascular medicine, with particular emphasis on their functional roles in physiology and disease. The book will include articles pertaining to mitochondrial fitness on a global basis, providing therefore an update on the progress made in several aspects in the field. Thus, it will assist scientists and clinicians alike in furthering basic and translational research. Organized in sections focusing on: basic science, mitochondrial dysfunction in cardiac disorders, in vascular disorders, in metabolic disorders, in kidney disease, therapeutic challenges and options, this essential volume fills imperative gaps in understanding and potentially treating several cardiovascular disorders.

Cancer as a Metabolic Disease

Cancer as a Metabolic Disease Book
Author : Thomas Seyfried
Publisher : John Wiley & Sons
Release : 2012-05-18
ISBN : 1118310306
Language : En, Es, Fr & De

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Book Description :

The book addresses controversies related to the origins of cancer and provides solutions to cancer management and prevention. It expands upon Otto Warburg's well-known theory that all cancer is a disease of energy metabolism. However, Warburg did not link his theory to the "hallmarks of cancer" and thus his theory was discredited. This book aims to provide evidence, through case studies, that cancer is primarily a metabolic disease requring metabolic solutions for its management and prevention. Support for this position is derived from critical assessment of current cancer theories. Brain cancer case studies are presented as a proof of principle for metabolic solutions to disease management, but similarities are drawn to other types of cancer, including breast and colon, due to the same cellular mutations that they demonstrate.

Mitochondrial Dysfunction

Mitochondrial Dysfunction Book
Author : Lawrence H. Lash,Dean P. Jones
Publisher : Unknown
Release : 1993
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Mitochondrial Dysfunction book written by Lawrence H. Lash,Dean P. Jones, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Mitochondrial Metabolism in Ischemic Heart Disease

Mitochondrial Metabolism in Ischemic Heart Disease Book
Author : Shijun Wang,Jian Wu,Lei-Lei Ma,Yang Li,Haiyang Tang
Publisher : Frontiers Media SA
Release : 2022-07-27
ISBN : 2889766209
Language : En, Es, Fr & De

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Book Description :

Download Mitochondrial Metabolism in Ischemic Heart Disease book written by Shijun Wang,Jian Wu,Lei-Lei Ma,Yang Li,Haiyang Tang, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The Role of Mitochondrial Metabolism and PGC 1 on Breast Cancer Bioenergetics and Metastasis

The Role of Mitochondrial Metabolism and PGC 1   on Breast Cancer Bioenergetics and Metastasis Book
Author : Sylvia Andrzejewski
Publisher : Unknown
Release : 2018
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Breast cancer is the most common cancer affecting women today. Although many advancements in treatment have been made, breast cancer is still the second leading cause of cancer-related deaths in Canadian women- demonstrating the need for a greater understanding of this complex disease. The re-wiring of cellular metabolism represents an important alteration in cancer cells that is needed to support their exponential growth. In addition, each step of cancer progression to metastatic disease presents novel bioenergetic and biosynthetic challenges, requiring metabolic adaptations within the cancer cells. Despite increasing knowledge about cancer progression, the characterization of such metabolic changes is incomplete. Classically, the Warburg effect states that cancer cells adopt an extremely glycolytic phenotype, taking up large amounts of glucose for rapid ATP production. Over the years this has been attributed to dysfunctional mitochondria in cancer cells. More recently however it is understood that mitochondria play vital roles in cancer progression and support various cellular metabolic rearrangements in cancer cells. In this work, we show a novel methodology to study isolated functional mitochondria from cancer cells in order to obtain insights into their intrinsic properties- to ultimately understand their contribution to cancer progression. Using this approach, we investigate and characterize the mode of action of metformin, the most commonly prescribed drug for the treatment of type II diabetes, which is being evaluated for use in cancer treatment. We show that metformin directly targets mitochondria and deregulates cellular bioenergetics and metabolism in cancer cells. Lastly, we investigate PGC-1, a central regulator of cellular and mitochondrial metabolism, and its role in breast cancer progression, metastasis and response to bioenergetic drugs. Overall, we elucidate the role of mitochondrial metabolism on cancer cell progression and metastasis as well as shed light on the effects of metformin on these processes.

Reviews on New Drug Targets in Age Related Disorders

Reviews on New Drug Targets in Age Related Disorders Book
Author : Paul C. Guest
Publisher : Springer Nature
Release : 2021-03-16
ISBN : 3030550354
Language : En, Es, Fr & De

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Book Description :

Aging is an inevitable part of life, and is becoming a worldwide social, economic and health problem due to the fact that an increasing proportion of individuals in the advanced age category have a higher probability of developing age-related disorders. New therapeutic approaches are still in need to decrease or slow the effects of such diseases in this aging society. Advances in ‘omic technologies such as genomics, transcriptomics, proteomics and metabolomics have significantly advanced our understanding of diseases in multiple medical areas. It is hoped that emerging hits from these analyses might be prioritized for further screening as potential novel drug targets for increasing the human healthspan in line with the lifespan, which will in turn lead to new therapeutic strategies and drug development projects by the pharmaceutical industry. This new book presents a series of reviews describing studies which have resulted in the identification of potential new drug targets for age-related disorders. Much of this information has come from ‘omic comparisons of healthy and disease states or from testing the effects of potential new therapeutic approaches. Each chapter will be presented in the context of specific chronic diseases or different therapeutic strategies, providing important information on disease mechanisms related to the aging process. This book will be of interest to researchers in the areas of aging and chronic disease, as well as clinical scientists, physicians, and major drug companies. With contributors from Australia, Brazil, Canada, France, Germany, India, Iran, Iraq, South Africa, South Korea, Thailand, Ukraine, United Kingdom, United States of America, Uruguay and Vietnam, this is a timely follow up to Guest’s previous book Reviews on New Drug Targets in Age-Related Disorders.

Novel Therapeutic Approaches for the Treatment of Ocular Disease Volume I

Novel Therapeutic Approaches for the Treatment of Ocular Disease  Volume I Book
Author : Kyriaki Thermos,Stephanie C. Joachim,Deniz Hos,Giovanni Casini
Publisher : Frontiers Media SA
Release : 2022-07-27
ISBN : 2889766284
Language : En, Es, Fr & De

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Book Description :

Download Novel Therapeutic Approaches for the Treatment of Ocular Disease Volume I book written by Kyriaki Thermos,Stephanie C. Joachim,Deniz Hos,Giovanni Casini, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Metabolism and Medicine

Metabolism and Medicine Book
Author : Brian Fertig
Publisher : CRC Press
Release : 2022-02-01
ISBN : 1000472140
Language : En, Es, Fr & De

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Book Description :

Chronic disease states of aging should be viewed through the prism of metabolism and biophysical processes at all levels of physiological organization present in the human body. This book connects these insights to what causes them to go awry in the context of unhealthy human behaviors and aging, aiming to buttress scientific creativity. It also provides links between the art and science of medicine that strengthens problem-solving in patient care. New and important discoveries in the area of metabolic health and metabolic diseases are discussed in exquisite detail. Key Features: Broad and up-to-date overview of the field of metabolic aspects of health and chronic disease development, especially connecting the spectrum of topics that range from molecular clocks to stress response to nuclear hormone receptors and the role of microbiota in human health Provides a deeper basic science and interdisciplinary understanding of biological systems that broaden the perspectives and therapeutic problem solving by elaborating on the usefulness of the Physiological Fitness Landscape Describes the importance of insulin resistance in metabolic disease, especially diabetes but also includes links to cancer and Alzheimer’s disease Examines the process of aging from the perspective of metabolic decline illustrating it with the Physiological Fitness Landscape This book, the second volume in a two-volume set, primarily targets an audience of clinical and science students, biomedical researchers and physicians who would benefit from understanding each other’s language.

Mitochondria in Obesity and Type 2 Diabetes

Mitochondria in Obesity and Type 2 Diabetes Book
Author : Beatrice Morio,Luc Penicaud,Michel Rigoulet
Publisher : Academic Press
Release : 2019-04-15
ISBN : 0128117524
Language : En, Es, Fr & De

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Book Description :

Mitochondria in Obesity and Type 2 Diabetes: Comprehensive Review on Mitochondrial Functioning and Involvement in Metabolic Diseases synthesizes discoveries from laboratories around the world, enhancing our understanding of the involvement of mitochondria in the etiology of diseases, such as obesity and type 2 diabetes. Chapters illustrate and provide an overview of key concepts on topics such as the role of mitochondria in adipose tissue, cancer, cardiovascular comorbidities, skeletal muscle, the liver, kidney, and more. This book is a must-have reference for students and educational teams in biology, physiology and medicine, and researchers. Synthesizes actual knowledge on mitochondrial function Provides an integrated vision of each tissue in the etiology of obesity and type 2 diabetes Identifies the interactive networks that involve alteration in mitochondrial mass and function in disease progression Highlights the role played by mitochondria in the prevention and treatment of obesity and type 2 diabetes

The Functions Disease Related Dysfunctions and Therapeutic Targeting of Neuronal Mitochondria

The Functions  Disease Related Dysfunctions  and Therapeutic Targeting of Neuronal Mitochondria Book
Author : J. Marie Hardwick
Publisher : John Wiley & Sons
Release : 2015-11-09
ISBN : 1118709233
Language : En, Es, Fr & De

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Book Description :

This book focuses on dysfunctional neuronal mitochondria, their functions, cell pathways, and properties and how they relate to therapeutics and pharmacology. For scientists and researchers in both industry and academia, this book provides detailed discussion, examples, and approaches, to illustrate the potential of mitochondria as therapeutic targets for neuronal diseases. The book is divided into three parts that cover mitochondrial structure and function, mitochondrial dysfunction and its relationship to neuronal disease, and targeting of dysfunctional neuronal mitochondria for drug development and therapeutics. 30 chapters cover hot and emerging topics in the field, like mitophagy and mitochondria in Parkinson's disease, bioenergetics, genetic diseases, the link between mitochondrial metabolic syndrome and Alzheimer's disease, Huntington's disease, novel neuroprotective agents, mitochondria-targeted peptide antioxidants, molecular chaperones for improved sensor recovery, mitochondrial function in diabetic neuropathy, among others. This book encompasses all of the necessary tools and perspectives to help decipher challenges in the field and lead to the development of strategies in more targeted approaches and personalized treatments.

The Role of Mitochondrial Metabolism and PGC 1 alpha on Breast Cancer Bioenergetics and Metastasis

The Role of Mitochondrial Metabolism and PGC 1 alpha  on Breast Cancer Bioenergetics and Metastasis Book
Author : Sylvia Andrzejewski
Publisher : Unknown
Release : 2018
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

"Breast cancer is the most common cancer affecting women today. Although many advancements in treatment have been made, breast cancer is still the second leading cause of cancer-related deaths in Canadian women- demonstrating the need for a greater understanding of this complex disease. The re-wiring of cellular metabolism represents an important alteration in cancer cells that is needed to support their exponential growth. In addition, each step of cancer progression to metastatic disease presents novel bioenergetic and biosynthetic challenges, requiring metabolic adaptations within the cancer cells. Despite increasing knowledge about cancer progression, the characterization of such metabolic changes is incomplete. Classically, the Warburg effect states that cancer cells adopt an extremely glycolytic phenotype, taking up large amounts of glucose for rapid ATP production. Over the years this has been attributed to dysfunctional mitochondria in cancer cells. More recently however it is understood that mitochondria play vital roles in cancer progression and support various cellular metabolic rearrangements in cancer cells. In this work, we show a novel methodology to study isolated functional mitochondria from cancer cells in order to obtain insights into their intrinsic properties- to ultimately understand their contribution to cancer progression. Using this approach, we investigate and characterize the mode of action of metformin, the most commonly prescribed drug for the treatment of type II diabetes, which is being evaluated for use in cancer treatment. We show that metformin directly targets mitochondria and deregulates cellular bioenergetics and metabolism in cancer cells. Lastly, we investigate PGC-1, a central regulator of cellular and mitochondrial metabolism, and its role in breast cancer progression, metastasis and response to bioenergetic drugs. Overall, we elucidate the role of mitochondrial metabolism on cancer cell progression and metastasis as well as shed light on the effects of metformin on these processes." --

Cardiac Energy Metabolism in Health and Disease

Cardiac Energy Metabolism in Health and Disease Book
Author : Gary D. Lopaschuk,Naranjan S. Dhalla
Publisher : Springer
Release : 2014-08-22
ISBN : 1493912275
Language : En, Es, Fr & De

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Book Description :

The heart has a very high energy demand but very little energy reserves. In order to sustain contractile function, the heart has to continually produce a large amount of ATP. The heart utilizes free fatty acids mainly and carbohydrates to some extent as substrates for making energy and any change in this energy supply can seriously compromise cardiac function. It has emerged that alterations in cardiac energy metabolism are a major contributor to the development of a number of different forms of heart disease. It is also now known that optimizing energy metabolism in the heart is a viable and important approach to treating various forms of heart disease. Cardiac Energy Metabolism in Health and Disease describes the research advances that have been made in understanding what controls cardiac energy metabolism at molecular, transcriptional and physiological levels. It also describes how alterations in energy metabolism contribute to the development of heart dysfunction and how optimization of energy metabolism can be used to treat heart disease. The topics covered include a discussion of the effects of myocardial ischemia, diabetes, obesity, hypertrophy, heart failure, and genetic disorders of mitochondrial oxidative metabolism on cardiac energetics. The treatment of heart disease by optimizing energy metabolism is also discussed, which includes increasing overall energy production as well as increasing the efficiency of energy production and switching energy substrate preference of the heart. This book will be a valuable source of information to graduate students, postdoctoral fellows, and investigators in the field of experimental cardiology as well as biochemists, physiologists, pharmacologists, cardiologists, cardiovascular surgeons and other health professionals.

Mitochondrial Mechanisms of Degeneration and Repair in Parkinson s Disease

Mitochondrial Mechanisms of Degeneration and Repair in Parkinson s Disease Book
Author : Lori M. Buhlman
Publisher : Springer
Release : 2016-09-13
ISBN : 3319421395
Language : En, Es, Fr & De

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Book Description :

This volume brings together various theories of how aberrations in mitochondrial function and morphology contribute to neurodegeneration in idiopathic and familial forms of Parkinson’s disease. Moreover, it comprehensively reviews the current search for therapies, and proposes how molecules are involved in specific functions as attractive therapeutic targets. It is expected to facilitate critical thought and discussion about the fundamental aspects of neurodegeneration in Parkinson’s disease and foster the development of therapeutic strategies among researchers and graduate students. Theories of idiopathic Parkinson’s etiology support roles for chronic inflammation and exposure to heavy metals or pesticides. Interestingly, as this project proposes, a case can be made that abnormalities in mitochondrial morphology and function are at the core of each of these theories. In fact, the most common approach to the generation of animal and cell-culture models of idiopathic Parkinson’s disease involves exposure to mitochondrial toxins. Even more compelling is the fact that most familial patients harbor genetic mutations that cause disruptions in normal mitochondrial morphology and function. While there remains to be no effective treatment for Parkinson’s disease, efforts to postpone, prevent and “cure” onset mitochondrial aberrations and neurodegeneration associated with Parkinson’s disease in various models are encouraging. While only about ten percent of Parkinson’s patients inherit disease-causing mutations, discovering common mechanisms by which familial forms of Parkinson’s disease manifest will likely shed light on the pathophysiology of the more common idiopathic form and provide insight to the general process of neurodegeneration, thus revealing therapeutic targets that will become more and more accessible as technology improves.

Mitochondria and Cancer

Mitochondria and Cancer Book
Author : Keshav Singh,Leslie Costello
Publisher : Springer Science & Business Media
Release : 2009-04-05
ISBN : 9780387848358
Language : En, Es, Fr & De

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Book Description :

Nearly a century of scientific research has revealed that mitochondrial dysfunction is one of the most common and consistent phenotypes of cancer cells. A number of notable differences in the mitochondria of normal and cancer cells have been described. These include differences in mitochondrial metabolic activity, molecular composition of mitochondria and mtDNA sequence, as well as in alteration of nuclear genes encoding mitochondrial proteins. This book, Mitochondria and Cancer, edited by Keshav K. Singh and Leslie C. Costello, presents thorough analyses of mitochondrial dysfunction as one of the hallmarks of cancer, discusses the clinical implications of mitochondrial defects in cancer, and as unique cellular targets for novel and selective anti-cancer therapy.

Inborn Errors of Metabolism

Inborn Errors of Metabolism Book
Author : Brendan Lee MD, PhD,Fernando Scaglia MD
Publisher : Oxford University Press
Release : 2014-10-01
ISBN : 0199797684
Language : En, Es, Fr & De

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Book Description :

Texts on inborn errors of metabolism (IEMs) have traditionally focused on classical biochemistry, clinical presentation, and standard treatment approaches. Inborn Errors of Metabolism is an expansion on this model, one that establishes an innovative pathway approach and provides a new authority on this family of disease. Alongside the standard cadre of molecular and clinical underpinnings, this volume includes coverage of newborn screenings and an overarching treatment of IEMs as complex diseases -- how basic alterations can lead to complex secondary and tertiary effects in metabolism that contribute to increasingly recognized natural histories of disease.

Current State of Alzheimer s Disease Research and Therapeutics

Current State of Alzheimer s Disease Research and Therapeutics Book
Author : Mary Lou Michaelis,Elias K. Michaelis
Publisher : Academic Press
Release : 2012
ISBN : 0123948169
Language : En, Es, Fr & De

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Book Description :

"Providing a cross-section of current research, treatments and potential clinical developments, this volume of Advances in Pharmacology is an essential resource for biologists, pharmacologists and those engaged with Alzheimer's research."--P. [4] of cover.

Anderson s Pediatric Cardiology E Book

Anderson   s Pediatric Cardiology E Book Book
Author : Robert H. Anderson,Kumar Krishna,Kathleen A. Mussato,Andrew Redington,James S. Tweddell,Justin Tretter
Publisher : Elsevier Health Sciences
Release : 2019-04-29
ISBN : 0702079243
Language : En, Es, Fr & De

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Book Description :

As a leading reference on pediatric cardiology and congenital heart disease, Anderson's Pediatric Cardiology provides exhaustive coverage of potential pediatric cardiovascular anomalies, potential sequelae related to these anomalies, comorbidities and neurodevelopmental problems, and current methods for management and treatment. The fully revised 4th Edition addresses significant and ongoing changes in practice, including recent developments in fetal, neonatal, and adult congenital heart conditions as well as expanded content on intensive care, nursing issues, and societal implications. The outstanding illustration program provides superb visual guidance, and is now supplemented with a remarkable collection of more than 200 professionally curated, author-narrated videos. Offers authoritative, long-term coverage of a broad spectrum of cardiology conditions ranging from fetal development to age 21, including congenital heart disease, adult congenital heart disease (ACHD), acquired heart disease, cardiomyopathies, and rhythm disturbances. Features exceptionally detailed and original drawings by Dr. Robert Anderson and Diane Spicer, including over 850 anatomic, photographic, imaging, and algorithmic figures, and incorporating new images using virtual dissections of 3D datasets obtained in living patients. Contains new chapters on quality improvement in congenital heart disease, models of care delivery, neurocognitive assessment and outcomes, psychosocial issues for patients and families, ethics, nursing implications, acute and chronic renal complications, and telemedicine. Offers a completely new section on fetal imaging and management. Provides a new focus on patient and family-centered care with expert advice on how to communicate difficult diagnoses to patients and families. Features new integration of nursing content into all disease-specific chapters, as well as updated content on genetics, congenital heart disease and follow-up, and new imaging modalities. Contains chapters on new and emerging topics such as MRI and Quantifying the Fetal Circulation in Congenital Cardiac Disease; Congenital Anomalies of the Coronary Arteries; and The Global Burden of Pediatric Heart Disease and Pediatric Cardiac Care in Low- and Middle-Income Countries. Shares the experience and knowledge of an international team of multidisciplinary experts in medicine and advanced practice nursing.

Mitochondria and Their Role in Cardiovascular Disease

Mitochondria and Their Role in Cardiovascular Disease Book
Author : José Marín-García
Publisher : Springer Science & Business Media
Release : 2012-11-19
ISBN : 146144599X
Language : En, Es, Fr & De

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Book Description :

Over the past two decades, due to dramatic advances in molecular and cell biology, biochemistry, and genetics, our view on mitochondria as a relatively static cellular powerhouse has changed radically. We now know that these organelles play a critical role in the normal and in the damaged heart. Written by Dr. José Marín-García, Director of the Molecular Cardiology and Neuromuscular Institute, Mitochondria and Their Role in Cardiovascular Disease brings readers up- to-date on the many significant advances in the field of mitochondrial cardiovascular medicine. The book begins with a general introduction to mitochondria, followed by laboratory methods to study the structure and function of the organelle, regulation of replication and biogenesis, and the mechanisms and functional consequences of mitophagia and mitochondrial dynamics. Subsequent chapters deal with mitochondrial oxidative stress and the role that the organelle plays in cell signaling and cell death. Discussions will be undertaken on the biochemistry of mitochondrial cell signaling, including the nature of the proteins engaged in these processes, many of them only recently discovered. Later chapters examine the role of mitochondria and mitochondrial abnormalities in cardiovascular diseases, including their diagnosis, therapeutic options currently available, animal models of mitochondrial disease, and new frontiers in mitochondria cardiovascular medicine, including areas of research that are relatively new or developing, such as proteomics, next generation sequencing, and systems biology.

Herbs for Diabetes and Neurological Disease Management

Herbs for Diabetes and Neurological Disease Management Book
Author : Vikas Kumar,Addepalli Veeranjaneyulu
Publisher : CRC Press
Release : 2018-01-02
ISBN : 1351801082
Language : En, Es, Fr & De

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Book Description :

This new volume provides a plethora of new information about potential medicinal herbs and their usefulness in treating diabetes and neurological diseases. Most large multinational companies are interested and engaged in the commercialization of herb-based formulations, and consumers continue to seek natural-based therapies. Herbs for Diabetes and Neurological Disease Management provides insight into plant-based novel molecules targeted for diabetes and neurological disorders. It looks at a selection of herbs that have proven effective in the management of diabetes and neurological disorders, including migraine, epilepsy, memory disorders, depression, and more. Divided into ten chapters focusing on diabetes and its macro- and microvascular complications (migraine, epilepsy, memory disorders, depression and other neuropsychiatric disorders), this book is structured to provide a source of reliable information and enrich the knowledge of readers. Each chapter briefly explains the epidemiology and pathophysiology of the disease state and the possible role of herbal drugs in the prevention of the particular disease. The reported pharmacological activities and possible mechanism of action of herbal drugs are also discussed in detail, which makes this book informative and unique. This new volume will be a reliable reference complementing the substantial information on the use of herbal drugs in diabetes and neurological disorders that serve as the pillars of drug discovery and development.