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Mitochondria In Neurological Disorders

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Mitochondrial Disorders in Neurology

Mitochondrial Disorders in Neurology Book
Author : Anthony Henry Vernon Schapira,Salvatore DiMauro
Publisher : Unknown
Release : 1994
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Mitochondrial Disorders in Neurology provides an overview of mitochondrial diseases. This book discusses the effects of mitochondrial dysfunction based on the relevant biochemistry and molecular genetics. The abnormal muscle and mitochondrial morphology in a variety of clinical presentations from isolated ophthalmoplegia to severe encephalopathy are also elaborated. This text likewise deliberates Leber's hereditary optic neuropathy, neurodegenerative disorders, and respiratory chain defects. Other topics covered include mitochondrial DNA and the genetics of mitochondrial disease; cytochrome ox ...

Mitochondria and Brain Disorders

Mitochondria and Brain Disorders Book
Author : Stavros Baloyannis
Publisher : BoD – Books on Demand
Release : 2020-03-11
ISBN : 1789855314
Language : En, Es, Fr & De

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Book Description :

The mitochondrion is a unique and ubiquitous organelle that contains its own genome, encoding essential proteins that are major components of the respiratory chain and energy production system. Mitochondria play a dominant role in the life and function of eukaryotic cells including neurons and glia, as their survival and activity depend upon mitochondrial energy production and supply. Besides energy production, mitochondria also play a vital role in calcium homeostasis and may induce apoptosis by excitotoxicity. Mitochondrial dysfunction is related to common neurological diseases, such as Parkinson's disease, Alzheimer's disease, Friedreich's ataxia, Huntington's disease, and Multiple Sclerosis. An efficient treatment of mitochondrial dysfunction would open new horizons in the therapeutic perspectives of a substantial number of inflammatory and degenerative neurological disorders.

Mitochondrial Dysfunction

Mitochondrial Dysfunction Book
Author : Lawrence H. Lash,Dean P. Jones
Publisher : Unknown
Release : 1993
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Mitochondrial Dysfunction book written by Lawrence H. Lash,Dean P. Jones, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Mitochondria in Neurological Disorders

Mitochondria in Neurological Disorders Book
Author : Rajat Sandhir
Publisher : Academic Press
Release : 2021-12-01
ISBN : 0128217324
Language : En, Es, Fr & De

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Book Description :

Mitochondria in Neurological Diseases highlights various therapeutic approaches targeting mitochondria in neurological conditions. Focused on diverse neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, depression, and Amyotrophic lateral sclerosis, topics span basic mitochondrial physiology to mitochondrial dynamics and to the altered states of the nervous system. This book is appropriate for anyone interested in learning more about the physiological and pathophysiological functions of mitochondria in the nervous system. Provides up-to-date information on role of mitochondria in nervous system for graduate students and researchers Presents chapters on energy substrate utilization, calcium handling, mitochondria-organelle communication, and cell signaling Discusses recent techniques in understanding mitochondrial functions in the nervous system Emphasizes the role of altered mitochondrial functions in various neurological conditions and their potential treatment strategies for targeting mitochondria Includes chapter references (key articles, books, protocols) for additional detailed study

The Functions Disease Related Dysfunctions and Therapeutic Targeting of Neuronal Mitochondria

The Functions  Disease Related Dysfunctions  and Therapeutic Targeting of Neuronal Mitochondria Book
Author : J. Marie Hardwick
Publisher : John Wiley & Sons
Release : 2015-11-09
ISBN : 1118709233
Language : En, Es, Fr & De

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Book Description :

This book focuses on dysfunctional neuronal mitochondria, their functions, cell pathways, and properties and how they relate to therapeutics and pharmacology. For scientists and researchers in both industry and academia, this book provides detailed discussion, examples, and approaches, to illustrate the potential of mitochondria as therapeutic targets for neuronal diseases. The book is divided into three parts that cover mitochondrial structure and function, mitochondrial dysfunction and its relationship to neuronal disease, and targeting of dysfunctional neuronal mitochondria for drug development and therapeutics. 30 chapters cover hot and emerging topics in the field, like mitophagy and mitochondria in Parkinson's disease, bioenergetics, genetic diseases, the link between mitochondrial metabolic syndrome and Alzheimer's disease, Huntington's disease, novel neuroprotective agents, mitochondria-targeted peptide antioxidants, molecular chaperones for improved sensor recovery, mitochondrial function in diabetic neuropathy, among others. This book encompasses all of the necessary tools and perspectives to help decipher challenges in the field and lead to the development of strategies in more targeted approaches and personalized treatments.

Clinical Mitochondrial Medicine

Clinical Mitochondrial Medicine Book
Author : Patrick F. Chinnery,Michael Keogh
Publisher : Cambridge University Press
Release : 2018-04-30
ISBN : 0521132983
Language : En, Es, Fr & De

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Book Description :

This interactive clinical textbook takes a system- and case-based approach in understanding mitochondrial disorders in clinical practice.

Mitochondrial Metabolism

Mitochondrial Metabolism Book
Author : Jalal Pourahmad,Mohsen Rezaei
Publisher : Academic Press
Release : 2021-07-28
ISBN : 0128224096
Language : En, Es, Fr & De

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Book Description :

Mitochondrial Metabolism: An Approach for Disease Management covers mitotherapy from three combined perspectives, Pharmacology, Toxicology and Biochemistry. After an introduction from world-renowned experts, the book's chapters cover the balancing role in reduction/oxidation mitochondria play, mitochondria as targets for therapeutics through its metabolism, mitochondrial contributions to the cell death process, mitochondrial response to environmental toxicants, the mitochondrial role in aging, the impact of calorie restrictive diets, new advances in the identification of altered mitochondria associated signaling pathways in carcinogenesis, and much more. This book provides bioscientists new horizons to realize the importance of mitochondria in present-day research on therapies dealing with mitochondria associated chronic diseases, including diabetes, cancer and neurodegenerative disorders. Details the significant role of mitochondria in chronic diseases Presents new insights on the targeting of mitochondria for therapeutic purposes Includes updated results on mitotherapy and other mitochondria-oriented therapies

Mitochondrial Dysfunction in Neurodegenerative Disorders

Mitochondrial Dysfunction in Neurodegenerative Disorders Book
Author : Amy Katherine Reeve,Kim Jennifer Krishnan,Michael R. Duchen,Doug M Turnbull
Publisher : Springer Science & Business Media
Release : 2011-11-15
ISBN : 9780857297013
Language : En, Es, Fr & De

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Book Description :

As age related diseases increase in prevalence and impact more significantly on medical resources it is imperative to understand these diseases and the mechanisms behind their progression. New research has stimulated a growing interest in mitochondrial involvement in neurodegenerative disorders such as Parkinson’s disease, Alzheimer’s disease and multiple sclerosis and the mechanisms which lead from mitochondrial dysfunction to neurodegeneration. Mitochondrial Dysfunction in Neurodegenerative Disorders brings together contributions from leaders in the field internationally on the various ways in which mitochondrial dysfunction contributes to the pathogenesis of these diseases, guiding the reader through the basic functions of mitochondria and the mechanisms that lead to their dysfunction, to the consequences of this dysfunction on neuronal function before finishing with the modelling of these disorders and discussion of new potential therapeutic targets. Mitochondrial Dysfunction in Neurodegenerative Disorders provides an accessible, authoritative guide to this important area for neurologists; research and clinical neuroscientists; neuropathologists; and residents with an interest in clinical research.

Mitochondrial Dynamics and Neurodegeneration

Mitochondrial Dynamics and Neurodegeneration Book
Author : Bingwei Lu
Publisher : Springer Science & Business Media
Release : 2011-05-16
ISBN : 940071291X
Language : En, Es, Fr & De

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Book Description :

Mitochondria are essential organelles in eukaryotic cells that control such diverse processes as energy metabolism, calcium buffering, and cell death. Recent studies have revealed that changes in mitochondrial morphology by fission and fusion, a process known as mitochondrial dynamics, is particularly important for neuronal function and survival. Defects in this process are commonly found in neurodegenerative diseases, offering a new paradigm for investigating mechanisms of neurodegeneration. To provide researchers working on neurodegenerative diseases and mitochondria with updated information on this rapidly progressing field, we have invited experts in the field to critically review recent progresses and identify future research directions. The topics include genetics of mitochondrial dynamics, mitochondrial dynamics and bioenergetics, autophagy, apoptosis, and axonal transport, and its role in neurological diseases, including Alzheimer’s, Parkinson’s, and Huntington’s diseases.

Mitochondria in Health and Disease

Mitochondria in Health and Disease Book
Author : Carolyn D. Berdanier
Publisher : CRC Press
Release : 2005-06-09
ISBN : 1420028847
Language : En, Es, Fr & De

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Book Description :

It was once assumed that mitochondrial diseases were rare and that few people were affected. As knowledge has grown about these organelles and their function, it became clear that mitochondrial malfunction could be linked to several chronic diseases. Diabetes has been associated with DNA mutation and can cause mutation itself. This text discusses findings involving the effects of disease on mitochondrial number, mitogenesis, and the base sequence of mitochondrial DNA. Experts discuss their study of mitochondria and what happens when it malfunctions. This book also explores the idea that mutated mitochondrial DNA can result in disease, and vice versa.

Diagnosis and Management of Mitochondrial Disorders

Diagnosis and Management of Mitochondrial Disorders Book
Author : Michelangelo Mancuso,Thomas Klopstock
Publisher : Springer
Release : 2019-03-30
ISBN : 9783030055165
Language : En, Es, Fr & De

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Book Description :

This book will help readers navigate the complexity of mitochondrial disorders, by addressing the role of mitochondrial dysfunction and the complex pathophysiological mechanisms associated with a growing number of illnesses, not only of neurological interest. Further, it provides updated concepts on genotype-phenotype correlations, clinical syndromes, diagnostic algorithms and therapies. Written by the world’s foremost mitochondrial researchers, the book comprehensively presents the state-of-the-art in mitochondrial medicine, making it of interest to a wide variety of specialists, including neurologists, geneticists, internists and biologists.

Cerebral and Cerebellar Cortex

Cerebral and Cerebellar Cortex Book
Author : Stavros J. Baloyannis
Publisher : BoD – Books on Demand
Release : 2021-09-15
ISBN : 1839680938
Language : En, Es, Fr & De

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Book Description :

Cerebral and Cerebellar Cortex – Interaction and Dynamics in Health and Disease discusses several important issues of cerebro-cerebellar collaboration and interactions. The morphological and functional study of the cerebral and cerebellar cortices and their interaction has considerable value for interpreting the clinical phenomenology of cortical degenerations in the initial stage of the disease. In addition, the analysis of cerebro-cerebellar interactions strongly supports the concept of the close functional unity and harmonization of the brain and the cerebellum, underlining the important role that the cerebellar cortex plays in the performance of higher mental faculties, creativity, emotional processes, and homeostatic equilibrium of the human body.

Mitochondrial Dysfunction in Ageing and Diseases

Mitochondrial Dysfunction in Ageing and Diseases Book
Author : Jaime M. Ross,Giuseppe Coppotelli,Lars Olson
Publisher : MDPI
Release : 2018-09-28
ISBN : 3038422517
Language : En, Es, Fr & De

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Book Description :

This book is a printed edition of the Special Issue "Mitochondrial Dysfunction in Ageing and Diseases" that was published in IJMS

Pharmacology of Mitochondria

Pharmacology of Mitochondria Book
Author : Harpreet Singh,Shey-Shing Sheu
Publisher : Springer
Release : 2017-08-11
ISBN : 3319573136
Language : En, Es, Fr & De

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Book Description :

This special book is conceived to highlight mitochondrial structural and functional integrity and how they are associated with several human diseases such as cardiovascular, cancer, renal, neurological disorder, and genetic disorders. The chapters contributed by leading mitochondrial researchers in the handbook will take us through the novel pharmacological strategies via mitochondria to understand their physiological and pathological role as well as present them as therapeutic targets.

Role of Mitochondria in Neurological Disease

Role of Mitochondria in Neurological Disease Book
Author : Anthony S. Basile
Publisher : Unknown
Release : 2002
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Role of Mitochondria in Neurological Disease book written by Anthony S. Basile, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Mitochondria and the Future of Medicine

Mitochondria and the Future of Medicine Book
Author : Lee Know
Publisher : Chelsea Green Publishing
Release : 2018
ISBN : 1603587675
Language : En, Es, Fr & De

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Book Description :

With information for patients and practitioners on optimizing mitochondrial function for greater health and longevity Why do we age? Why does cancer develop? What's the connection between heart failure and Alzheimer's disease, or infertility and hearing loss? Can we extend lifespan, and if so, how? What is the Exercise Paradox? Why do antioxidant supplements sometimes do more harm than good? Many will be amazed to learn that all these questions, and many more, can be answered by a single point of discussion: mitochondria and bioenergetics. In Mitochondria and the Future of Medicine, Naturopathic Doctor Lee Know tells the epic story of mitochondria, the widely misunderstood and often-overlooked powerhouses of our cells. The legendary saga began over two billion years ago, when one bacterium entered another without being digested, which would evolve to create the first mitochondrion. Since then, for life to exist beyond single-celled bacteria, it's the mitochondria that have been responsible for this life-giving energy. By understanding how our mitochondria work, in fact, it is possible to add years to our lives, and life to our years. Current research, however, has revealed a dark side: many seemingly disconnected degenerative diseases have tangled roots in dysfunctional mitochondria. However, modern research has also endowed us with the knowledge on how to optimize its function, which is of critical importance to our health and longevity. Lee Know offers cutting-edge information on supplementation and lifestyle changes for mitochondrial optimization, such as CoQ10, D-Ribose, cannabinoids, and ketogenic dietary therapy, and how to implement their use successfully. Mitochondria and the Future of Medicine is an invaluable resource for practitioners interested in mitochondrial medicine and the true roots of chronic illness and disease, as well as anyone interested in optimizing their health.

Mitochondrial Medicine

Mitochondrial Medicine Book
Author : Salvatore DiMauro,Michio Hirano,Eric A. Schon
Publisher : CRC Press
Release : 2019-11-26
ISBN : 9780367446369
Language : En, Es, Fr & De

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Book Description :

Mitochondrial dysfunction is increasingly being recognized as the basis of a wide variety of human diseases. Providing an authoritative update on our current knowledge of mitochondrial medicine, this text draws together world authorities from various fields to present general therapeutic strategies, as well as the treatments presently available in different specialties - thus making it essential reading for clinicians involved with the management of patients with mitochondrial diseases. A unique work, this text covers a range of specialties, including cardiology, ophthalmology, otology, nephrology, gastroenterology, hematology-oncology, and reproductive medicine, and does not focus exclusively on the more commonly known neurologic conditions. An accessible, user-friendly text, it also presents translational concepts of mitochondrial biogenesis and genetics in vignettes related to specific questions raised by the disease under discussion, rather than concentrating on basic science, which can often intimidate clinicians. This pioneering work is primarily directed to a clinical audience who are interested in the diverse and diagnostically challenging clinical presentations of mitochondrial diseases and their pathophysiology.

Mitochondrial Dysfunction in Aging and Diseases of Aging

Mitochondrial Dysfunction in Aging and Diseases of Aging Book
Author : Richard H. Haas
Publisher : MDPI
Release : 2019-10-01
ISBN : 303921327X
Language : En, Es, Fr & De

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Book Description :

This collection of review articles authored by international experts pulls together current information about the role of mitochondria in aging and diseases of aging. Mitochondria are vitally important cellular organelles and undergo their own aging process becoming less efficient in aged animals including humans. These changes have wide-ranging significance contributing to immune dysfunction (autoimmunity and immune deficiency), inflammation, delayed healing, skin and retinal damage, cancer and most of the degenerative diseases of aging. Mitochondrial aging predisposes to drug toxicity in the geriatric population and to many of the features of normal aging. The research detailed in this book summarizes current understanding of the role of mitochondria in the complex molecular changes of aging, moving on to specific diseases of aging. Mitochondrial dysfunction is an important target for development of treatments for aging and disease. The last article details how exercise is a treatment and combats many features of the aging process.

Cerebellar Disorders

Cerebellar Disorders Book
Author : Mario Ubaldo Manto
Publisher : Cambridge University Press
Release : 2010-03-25
ISBN : 1139487264
Language : En, Es, Fr & De

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Book Description :

During the last three decades, many laboratories worldwide have dedicated their research activities to understanding the roles of the cerebellum in motor control, cognitive processes and the biology of mental processes, behavioral symptoms and emotion. These advances have been associated with discoveries of new clinical disorders, in particular in the field of genetic ataxias, and the growing number of diseases presents a source of difficulty for clinicians during daily practice. This practical guide summarizes and evaluates current knowledge in the field of cerebellar disorders. Encompassing details of both common and uncommon cerebellar ataxias, including vascular, immune, neoplastic, infectious, traumatic, toxic and inherited disorders, this book will assist clinicians in the diagnosis and management of the full spectrum of cerebellar ataxias encountered in daily practice. Essential reading for clinicians, including general practitioners, neurologists, pediatricians, radiologists, psychiatrists and neuropsychologists, this will also prove a valuable tool for students, trainees and researchers.

Neuroprotection

Neuroprotection Book
Author : Matilde Otero-Losada,Francisco Capani,Santiago Perez Lloret
Publisher : BoD – Books on Demand
Release : 2020-11-26
ISBN : 1838804390
Language : En, Es, Fr & De

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Book Description :

Neurological disease affects nearly 25%–30% of the world’s population, exerting enormous financial strain on the healthcare system. Estimated current costs are around $800 annual billion, and this number is expected to increase exponentially as the global population ages. As such, new and alternative neuroprotective strategies are urgently needed. This book examines some of the most promising approaches in neuroprotection as well as discusses current goals and prospects. Organized into three sections, chapters cover such topics as the use of cannabinoids, medicinal plants, and essential oils in Alzheimer’s and Parkinson’s; protein misfolding and the neuroprotective potential of vitamin E in cerebral ischemia; and potential new neurological treatments and their mechanisms of action.