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Micrornas And Epigenetic Regulation

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Epigenetic Regulation in the Nervous System

Epigenetic Regulation in the Nervous System Book
Author : Quan Lin,Yi E. Sun
Publisher : Elsevier Inc. Chapters
Release : 2012-12-31
ISBN : 0128058447
Language : En, Es, Fr & De

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Download Epigenetic Regulation in the Nervous System book written by Quan Lin,Yi E. Sun, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Epigenetic Regulation of MicroRNAs in Chronic Lymphocytic Leukemia

Epigenetic Regulation of MicroRNAs in Chronic Lymphocytic Leukemia Book
Author : Constance Regina Bär
Publisher : Unknown
Release : 2013
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Download Epigenetic Regulation of MicroRNAs in Chronic Lymphocytic Leukemia book written by Constance Regina Bär, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Epigenetics of B Cells and Antibody Responses

Epigenetics of B Cells and Antibody Responses Book
Author : Paolo Casali
Publisher : Frontiers Media SA
Release : 2016-04-12
ISBN : 2889197905
Language : En, Es, Fr & De

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Book Description :

Epigenetics is the study of changes in gene activity that are heritable but not caused by changes in the DNA sequence. By modulating gene activities, epigenetic changes regulate cell functions. They include DNA methylation, histone posttranslational modifications and gene silencing by the action of non-coding RNAs, particularly microRNAs. It is now clear that epigenetic changes regulate B cell development. By acting in concert with networks of transcription factors, they modulate the activation of B cell lineage specific gene programs and repress inappropriate gene transcription in particular B cell differentiation states.

A hallmark of B cell development in the bone marrow is the assembly of the B cell receptor (BCR) for antigen through rearrangement of immunoglobulin heavy (IgH) and light (IgL) chain V(D)J genes, as mediated by RAG1/RAG2 recombinases. Ig V(D)J rearrangement critically times the progression from pro-B cell to pre-B cell and, finally, mature B cell. Such progression is modulated by epigenetic marks, such as DNA methylation and histone posttranslational modifications, that increase chromatin accessibility and target RAG/RAG2 to V, D and J DNA. It is also dependent on the expression of multiple microRNAs. Mice deficient in Ago2, which is essential for microRNA biogenesis and function, have B cell development blocked at the pro-B cell stage. In agreement with this, B cell specific ablation of microRNA by B cell-specific knockout of Dicer virtually blocks B cell differentiation at the pro-B to pre-B cell transition.

After mature B cells encounter antigen, changes of the epigenetic landscape are induced by the same stimuli that drive the antibody response; such epigenetic changes underpin the maturation of the antibody response itself. They instruct those B cell differentiation processes, somatic hypermutation (SHM), class switch DNA recombination (CSR) and plasma cell differentiation, that are central to the maturation of the antibody response as well as differentiation of memory B cells. Inducible histone modifications, together with DNA methylation and microRNAs modulate the transcriptome, particularly the expression of activation-induced cytidine deaminase (AID), central to SHM and CSR, and B lymphocyte-induced maturation protein-1 (Blimp-1), which is central to plasma cell differentiation.

Combinatorial histone modifications also function as histone codes in the targeting of the CSR and, possibly, the SHM machinery to the Ig locus by recruiting specific adaptors (histone code readers) that can in turn target and/or stabilize CSR/SHM factors. Epigenetic alterations in memory B cells contribute to their functionally distinction from their naive counterparts. Memory B cells inherit epigenetic information from their precursors and acquire new epigenetic marks, which make these resting B cells poised to promptly respond to antigen. The cross/feedback regulation of different epigenetic modifications/elements further increases the complexity of the B cell epigenome, which interacts with the genetic information for precise modulation of gene expression. It is increasingly evident that epigenetic dysregulation in B cells, including aberrant expression of microRNAs, can result in aberrant antibody responses to microbial pathogens, emergence of pathogenic autoantibodies or B cell neoplastic transformation. Epigenetic marks are potential targets for new therapeutics in autoimmunity and B cell malignancy.

Epigenetics of Chronic Pain

Epigenetics of Chronic Pain Book
Author : Anonim
Publisher : Academic Press
Release : 2018-10-29
ISBN : 0128140712
Language : En, Es, Fr & De

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Book Description :

Epigenetics of Chronic Pain, Volume Nine, presents comprehensive information on the role of epigenetics in chronic pain sensitivity, providing a detailed, but accessible, view of the field from basic principles, to clinical application. Leading international researchers discuss essential mechanisms of chronic pain epigenetics, including the molecular processes of chromatin remodeling, histone modifications, and the microRNAs and noncoding RNAs involved in regulating genes tied to pain sensitivity. The influence of epigenetics in inflammatory, neuropathic, visceral and other pain models is examined, with data derived from epigenetic studies on peripheral and central mechanisms of pain sensitivity in animal models and clinical cases studies. The studies and case examples cited highlight therapeutic pathways of significance and next steps for researchers to develop epigenetic-based treatments for chronic pain. In recent years, epigenetic regulation of gene expression has been shown to play a central role in managing human pain sensitivity. Findings show that expression of many genes critical to increases or decreases in pain sensitivity are indeed regulated by DNA methylation and its enzymes, histone-involved chromatin remodeling, and noncoding RNAs, mainly microRNAs. Compiles all known information on epigenetic regulation of chronic pain in one volume Covers the basic functionality of epigenetic mechanisms involved in pain management, applications of recent research in understanding different types of chronic pain, and pathways for developing therapeutics Leading international researchers from across academia, clinical settings, and the pharmaceutical industry discuss epigenetics in inflammatory, neuropathic, visceral, and other pain models in-depth Enables clinicians, researchers, and pharmacologists to better understand and treat chronic pain

Interplay of Epigenetics with Gynecological Cancer

Interplay of Epigenetics with Gynecological Cancer Book
Author : Coralia Bleotu
Publisher : Unknown
Release : 2016
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Recent data on the cell deregulation that occurs during the progression to cancer underlines the cooperation between genetic and epigenetic alterations leading to a malignant phenotype. Unlike genetic alterations, the epigenetic changes do not affect the DNA sequence of the genes, but determine the regulation of gene expression acting upon the genome. Moreover, unlike genetic changes, epigenetic ones are reversible, making them therapeutic targets in various conditions in general and in cancer disease in particular. The term epigenetics includes a series of covalent modifications that regulate the methylation pattern of DNA and posttranslational modifications of histones. Gene expression can also be regulated at the posttranscriptional level by microRNAs (miRNAs), a family of small noncoding RNAs that inhibit the translation of mRNA to protein. miRNAs can act as 'oncomiRs', as tumor suppressors, or both. In this chapter, we will (1) summarize the current literature on the key processes responsible for epigenetic regulation: DNA methylation, histone modifications and posttranscriptional gene regulation by miRNAs; (2) evaluate aberrant epigenetic modifications as essential players in cancer progression; (3) establish the roles of microenvironment-mediated epigenetic perturbations in the development of gynecological neoplasia; (4) evaluate epigenetic factors involved in drug resistance.

Epigenetic Regulation in the Nervous System

Epigenetic Regulation in the Nervous System Book
Author : J. David Sweatt,Eric J. Nestler,Michael J. Meaney,Schahram Akbarian
Publisher : Elsevier Inc. Chapters
Release : 2012-12-31
ISBN : 0128058366
Language : En, Es, Fr & De

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Book Description :

Download Epigenetic Regulation in the Nervous System book written by J. David Sweatt,Eric J. Nestler,Michael J. Meaney,Schahram Akbarian, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Cross talk Between Epigenetic Regulation and Mir 17 92 Cluster Expression in Idiopathic Pulmonary Fibrosis IPF

Cross talk Between Epigenetic Regulation and Mir 17 92 Cluster Expression in Idiopathic Pulmonary Fibrosis  IPF  Book
Author : Duaa Dakhlallah
Publisher : Unknown
Release : 2011
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Abstract: Interstitial lung disease/idiopathic pulmonary fibrosis (ILD/IPF) is the most progressive form of pulmonary fibrosis disorder and leads to death in patients afflicted. The etiology and pathogenesis of ILD/IPF in poorly understood with no known prevention or cure available. ILD/IPF is associated with increased expression of certain fibrogenic genes such as CTGF, VEGF, GM-CSF, and TSP-1; however, the precise mechanism responsible for the increased gene and protein expression is not known. Since there are a large number of genes differentially expressed in the lungs of patients with ILD/IPF compared to controls, we speculated that elements like microRNAs (miRNAs) may be involved. miRNAs, also known as miRs, are small regulatory RNAs that alter gene expression by causing degradation, translational repression, or epigenetic regulation resulting in a change in protein expression. Changes in miRNA expression are associated with up to 30% of cancers (Volinia et. al., 2010) and a variety of other diseases (Nana-Sinkam et. al., 2009). Using miRNA profiling, we identified a specific miRNA cluster that was reduced in expression in ILD/IPF lung tissue compared to normal lung tissue and lung tissue from patients with chronic obstructive pulmonary disease (COPD), the miR-17~92 cluster. The miR-17~92 polycistron cluster is ~ 1Kb located within the third intron of the open reading frame13q31.3 (C13orf25) which encodes six microRNAs (miR-17, miR-18a, miR-19a, miR-20a, miR-19b-1 and miR-92a-1). This locus is overexpressed in B-cell lymphomas and lung cancer. In ILD/IPF, miR-17~92 miRNA cluster targets genes, such as metalloproteinases, collagen, and transforming growth factor that are highly expressed. Our preliminary data indicated decreased expression of the miR-17~92 miRNA cluster family members in the lungs from patients with ILD/IPF. Notably, miR-19b and miR-20a decreased proportionally to disease severity (and pulmonary function) of ILD/IPF. In ILD/IPF lung tissue, miR-19b and miR-20a expression was reduced and its predicted targets, CTGF, VEGF, TGF-[beta], TSP-1 and Ets-1 were up-regulated. Importantly, we noticed that the 5'-region of the promoter is heavily occupied with CpG Islands (>90%) and sought to define if this area was affected by methylation in ILD/IPF, as the mechanism causing downregulation of the cluster expression in ILD/IPF. Our preliminary data suggested that this epigenetic silencing of miR-17~92 clusters was due to methylation of the promoter, and was increased with the severity of ILD/IPF. Indeed, we found this CpG island methylated in ILD/IPF and by relieving this methylation with 5'-aza-2'-deoxycytidine, enhanced cluster expression and decreased expression of the target genes. In addition, we found that the miR-17~92 cluster targeted DNA methyltransferases (DNMTs), which we believe are responsible for the methylation events in ILD/IPF. Interestingly, our data showed direct regulation of miR-17, miR-19b, miR-20a and miR-92 on the 3'UTR of DNMT-1 in lung fibroblasts isolated from patients with IPF, indicating a negative feedback mechanism of the cluster to its own promoter though an epigenetic modifier. In fact, inhibition of DNA methylation by 5'-aza-2'-deoxycytidine in our in vivo murine bleomycin-induced pulmonary fibrosis model recovered miR-17~92 cluster expression to that of normal lung tissue, rescued the animals' lungs from fibrosis, and decreased fibrotic gene expression in their lungs. Thus, our data indicate that dysregulation of miRNA expression in IPF may contribute to the development and/or progression of the disease. 5'-aza-2'-deoxycytidine treatment, or miR-17~92 overexpression, could be a therapeutic intervention in ILD/IPF.

Current Perspectives in microRNAs miRNA

Current Perspectives in microRNAs  miRNA  Book
Author : Shao-Yao Ying
Publisher : Springer Science & Business Media
Release : 2008-09-12
ISBN : 1402085338
Language : En, Es, Fr & De

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Book Description :

Nearly 97% of the human genome is the non-coding DNA, which varies from one species to another, and changes in these sequences are frequently noticed to manifest clinical and circumstantial malfunction. Numerous non-protein-coding genes are recently found to encode microRNAs, which are responsible for RNA-mediated gene silencing through RNA interference (RNAi)-like pathways. MicroRNAs (miRNAs), small single-stranded 17–25 nucleotide RNAs capable of interfering with intracellular messenger RNAs (mRNAs) that contain either complete or partial complementarity, are useful for the design of new therapies against cancer polymorphism and viral mutation. Currently over 1000 native miRNA species found in vertebrates and many more new miRNA homologs continue to be identified; however, most of their functions remain to be determined. In this book, many new perspectives of the miRNA research are reviewed and discussed, including their roles in stem cell maintenance, embryonic development, tissue differentiation, adult physiology, disease pathology, cancer research, viral infection, genetic engineering in plants, and utility in cosmetic applications. These new findings may not only provide significant insight into the various mechanisms of miRNAs but also offer a great opportunity in developing new therapeutic interventions.

miRNA and Cancer

miRNA and Cancer Book
Author : Anonim
Publisher : Academic Press
Release : 2017-09-04
ISBN : 0128119233
Language : En, Es, Fr & De

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Book Description :

miRNA and Cancer, Volume 135, the latest volume in the Advances in Cancer Research series, provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents original reviews on research bridging oncology and gene expression, and includes specific chapters on Non-coding RNAs as Biomarkers of Cancer, The Enigma of microRNA Regulation in Cancer, Animal Models to Study microRNA functions, Non-coding RNAs and Cancer, microRNAs in Cancer Susceptibility, ts-RNAs versus microRNAs, microRNAs and AML, and microRNAs and Epigenetics. Provides information on cancer research Offers outstanding and original reviews on a range of cancer research topics Serves as an indispensable reference for researchers and students alike

Epigenetic Regulation and Epigenomics

Epigenetic Regulation and Epigenomics Book
Author : Robert A. Meyers
Publisher : John Wiley & Sons
Release : 2012-10-02
ISBN : 3527668624
Language : En, Es, Fr & De

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Book Description :

Epigenetics is a term in biology referring to heritable traits that do not involve changes in the underlying DNA sequence of the organism. Epigenetic traits exist on top of or in addition to the traditional molecular basis for inheritance. The "epigenome" is a parallel to the word "genome," and refers to the overall epigenetic state of a cell. Cancer and stem cell research have gradually focused attention on these genome modifications. The molecular basis of epigenetics involves modifications to DNA and the chromatin proteins that associate with it. Methylation, for example, can silence a nearby gene and seems to be involved in some cancers. Epigenetics is beginning to form and take shape as a new scientific discipline, which will have a major impact on Medicine and essentially all fields of biology. Increasingly, researchers are unearthing links between epigenetics and a number of diseases. Although in recent years cancer has been the main focus of epigenetics, recent data suggests that epigenetic plays a critical role in psychology and psychopathology. It is being realized that normal behaviors such as maternal care and pathologies such as Schizophrenia and Alzheimer's might have an epigenetic basis. It is also becoming clear that nutrition and life experiences have epigenetic consequences. Discover more online content in the Encyclopedia of Molecular Cell Biology and Molecular Medicine.

Epigenetics and Cancer

Epigenetics and Cancer Book
Author : Fazlul H. Sarkar
Publisher : Springer Science & Business Media
Release : 2013-05-29
ISBN : 9400766122
Language : En, Es, Fr & De

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Book Description :

Overall, this book illustrates the complexities of the regulation and deregulation of genes mediated through epigenetics in the development and progression of human malignancies. All the articles have been carefully chosen to represent several cancer systems with state of our knowledge on the role of epigenetic deregulation of microRNAs (miRNAs) and their target mRNAs along with epigenetic deregulation of mRNAs. This book also illustrates the role of several dietary agents, collectively called nutraceuticals or natural agents in modulating the epigenetic reprogramming of miRNAs and mRNAs for the prevention and/or treatment of human malignancies. It is well known that genetic aberrations, especially inherited through parents (somatic genetic alterations) contribute to the development of less than 10% of all cancer yet epigenetic alterations in genes especially through selective methylation and acetylation appears to be responsible for the development and progression of the vast majority of all cancers. Therefore, understanding the role of epigenetics in the regulation of genes especially through deregulated expression of miRNAs as presented in this book will allow scientists to devise targeted therapeutic strategies for re-expression of the lost genes or down-regulate the genes that are over-expressed in order to eradicate cancer. It is hoped that targeting epigenetics will not only target cancer cells but it will also target the tumor microenvironment (more like the entire tumor environment such as the entire host) for achieving better treatment outcomes for patients diagnosed with cancer which will lead to achieve the long-term objective for complete eradication of cancer. This book contains fifteen chapters which begins with the concept of systems and network biology for investigating the epigenetics of cancer followed by a series of articles on the role of miRNAs and their target genes in the biology of pancreatic cancer and other cancers such as breast, kidney, prostate and and colon. Since it is becoming increasingly clear that cancer stem cells (CSCs) are important in the development and progression of cancer, and CSCs are important in therapeutic resistance, treatment failure and tumor recurrence, thus the importance of CSCs and epigenetics has been highlighted by a very timely article on epigenetic variations of stem cell markers in cancer including miRNAs. Moreover, just targeting heterogeneous cancer cell populations may not be optimal to eradicate tumors and for which one must take a holistic approach for developing drugs that could also target the tumor microenvironment and tumor dormancy that are regulated through epigenetics. Keeping abreast with this thought process the concluding chapter provides a concept towards curative cancer therapy with maspin, which could be a unique window of opportunity to target tumor dormancy. Therefore, it suggest that targeting the tumor dormancy and the tumor microenvironment using novel therapeutics specifically by targeting epigenetics would become the future of medicine.

Epigenetic Regulation in the Nervous System

Epigenetic Regulation in the Nervous System Book
Author : J. David Sweatt,Michael J. Meaney,Eric J. Nestler,Schahram Akbarian
Publisher : Academic Press
Release : 2012-12-31
ISBN : 0123944058
Language : En, Es, Fr & De

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Book Description :

Epigenetic Regulation in the Nervous System addresses current understanding of the roles of epigenetic processes at the molecular/cellular level, their impact on neural development and behavior, and the potential roles of these mechanisms in neurological and psychiatric disorders. This award-winning volume spans molecular epigenetics, development, cellular physiology and biochemistry, synaptic and neural plasticity, and behavioral models, and is unique in covering epigenetically based disorders of the central nervous system. Behavioral epigenetics is the study of how environmental factors alter behavior, addressing the fundamental mechanisms that shape development and individual vulnerability/resilience to adverse behavioral outcomes. By understanding the molecular mechanisms involved in epigenetic modulation, researchers may be able to develop targeted therapies for those individuals in whom it malfunctions. Edited by the most highly regarded leaders in the field, this book offers a comprehensive review of behavioral epigenetics and a balanced treatment of the strengths and weaknesses in experimentation in this area. Covering background material as well as topics of current interest, it serves both as a cutting-edge resource and a foundational reference. The book will benefit neuroscience researchers and graduate students with an interest in the links between gene regulation and behavior, as will clinicians dealing with disorders such as addiction, depression, and schizophrenia. BMA Medical Book Awards 2014 - Highly Commended, Neurology, British Medical Association BMA Medical Book Awards 2014 - First Prize, Neurology, British Medical Association 2013 PROSE Award winner for Best in Reference Works and Best Single Volume Reference in Science from the Association of American Publishers Presents a unified view of epigenetic mechanisms from behavior to genes and everything in between Discusses clinically relevant disorders in the context of epigenetics research, making the volume appealing to clinicians as well as basic scientists Provides numerous practical examples for the new investigator to facilitate implementation of research in neuroepigenetics

Epigenetic Regulation in the Nervous System

Epigenetic Regulation in the Nervous System Book
Author : Isabelle M. Mansuy,Rahia Mashoodh,Frances A. Champagne
Publisher : Elsevier Inc. Chapters
Release : 2012-12-31
ISBN : 012805848X
Language : En, Es, Fr & De

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Book Description :

Download Epigenetic Regulation in the Nervous System book written by Isabelle M. Mansuy,Rahia Mashoodh,Frances A. Champagne, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Epigenetic Shaping of Sociosexual Interactions From Plants to Humans

Epigenetic Shaping of Sociosexual Interactions  From Plants to Humans Book
Author : Anonim
Publisher : Academic Press
Release : 2014-08-22
ISBN : 0128003332
Language : En, Es, Fr & De

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Book Description :

Epigenetic Shaping of Sociosexual Interactions: From Plants to Humans is the first attempt to interpret the higher social functions of organisms. This volume covers an extraordinarily wide range of biological research and provides a novel framework for understanding human-specific brain functions. Covers an extraordinarily wide range of biological research Provides a novel framework for understanding human-specific brain functions.

Pitx2 Expression and Epigenetic Regulation of Muscle Cell Differentiation

Pitx2 Expression and Epigenetic Regulation of Muscle Cell Differentiation Book
Author : Jing Rong
Publisher : Unknown
Release : 2014
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Epigenetic modifications are heritable, stable and potentially reversible changes in gene expression, and occur without change in DNA sequence. These changes may involve DNA methylation, histone acetylation, or regulation of non-coding RNAs such as microRNAs. The significance of epigenetic modifications has been highlighted in human diseases ranging from inherited cancer to muscular dystrophy. In our previous study, significant DNA methylation change of paired-like homedomain 2 (Pitx2) gene was found in human skeletal muscle of the kwashiorkor and marasmus survivors; three CpG sites on Pitx2 were differentially methylated. Therefore, this study explores the relationship between Pitx2 expression and epigenetic modifications, in particular DNA methylation and microRNA regulation, during myogenic differentiation by using the murine C2C12 myoblast cell line as an in vitro muscle cell model. It was found that Pitx2 expression change during myogenic differentiation in C2C12 myoblasts was not accompanied by the DNA methylation change in the three CpG sites of interest. In addition, following Pitx2 knock-down and myogenic differentiation in C2C12 myoblasts, two myogenic regulators Myf5 and Myogenin were up-regulated and microRNA miR-127 and miR-486 expression were significantly inhibited. In addition, miR-27a, miR-29b and miR-133a tended to decrease following Pitx2 knock-down. Overall data suggest that Pitx2 may participate in the myogenic regulatory network through regulating microRNA at least via miR-486. Furthermore, results from this study also suggest that Myogenin may be an important mediator in these regulatory pathways.

Nutritional Epigenomics

Nutritional Epigenomics Book
Author : Anonim
Publisher : Academic Press
Release : 2019-07-20
ISBN : 0128173106
Language : En, Es, Fr & De

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Book Description :

Nutritional Epigenomics offers a comprehensive overview of nutritional epigenomics as a mode of study, along with nutrition’s role in the epigenomic regulation of disease, health and developmental processes. Here, an expert team of international contributors introduces readers to nutritional epigenomic regulators of gene expression, our diet’s role in epigenomic regulation of disease and disease inheritance, caloric restriction and exercise as they relate to recent epigenomic findings, and the influence of nutritional epigenomics over circadian rhythms, aging and longevity, and fetal health and development, among other processes. Disease specific chapters address metabolic disease (obesity and diabetes), cancer, and neurodegeneration, among other disorders. Diet-gut microbiome interactions in the epigenomic regulation of disease are also discussed, as is the role of micronutrients and milk miRNAs in epigenetic regulation. Finally, chapter authors examine ongoing discussions of race and ethnicity in the social-epigenomic regulation of health and disease. Empowers the reader to employ nutritional epigenomics approaches in their own research Discusses the latest topics in nutritional epigenomics in the regulation of aging, circadian rhythm, inheritance and fetal development, as well as metabolism and disease Offers a full grounding in epigenetic reprogramming and nutritional intervention in the treatment and prevention of disease, as informed by population-based studies

Insect Epigenetics

Insect Epigenetics Book
Author : Anonim
Publisher : Academic Press
Release : 2017-08-24
ISBN : 0128118342
Language : En, Es, Fr & De

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Book Description :

Insect Epigenetics, Volume 53 provides readers with the latest interdisciplinary reviews on the topic. Updated chapters in this new release include Epigenetics in insects: Mechanisms, ecological outcomes, and evolutionary consequences, Nutrition and epigenetic change in insects, microRNAs in Drosophila insulin regulation, Epigenetic regulation of longevity in insects, Epigenetic influences on diapause, the Impact of parasites on epigenetics of their insect hosts, The molecular physiology of locust swarming behavior, The future of environmental epigenetics: insights using the clonal water-flea model, and. Epigenetics – A hidden target of insecticides. Led by volume editor Heleen Verlinden, this is an essential reference source for entomologists, zoologists, geneticists and insect chemists. Presents a comprehensive overview of environmental impacts on insect epigenetics Written by leaders in their respective areas of research Ideal resource for entomologists, zoologists, geneticists and insect chemists

Environmental Epigenetics

Environmental Epigenetics Book
Author : L. Joseph Su,Tung-chin Chiang
Publisher : Springer
Release : 2015-05-18
ISBN : 1447166787
Language : En, Es, Fr & De

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Book Description :

This book examines the toxicological and health implications of environmental epigenetics and provides knowledge through an interdisciplinary approach. Included in this volume are chapters outlining various environmental risk factors such as phthalates and dietary components, life states such as pregnancy and ageing, hormonal and metabolic considerations and specific disease risks such as cancer cardiovascular diseases and other non-communicable diseases. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses.

MicroRNA and Cancer

MicroRNA and Cancer Book
Author : Wei Wu
Publisher : Humana Press
Release : 2016-08-23
ISBN : 9781493957743
Language : En, Es, Fr & De

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Book Description :

The tiny microRNAs (miRNAs) can have huge impacts on the regulation of a variety of genes and play crucial roles in the fundamental cellular processes. Recent miRNA studies change the landscape of cancer genetics by scrutinizing the alterations of genome-wide miRNA expressions in most common cancers and their regulatory functions during the development of cancer. The connections between miRNAs and cancer are widespread enough to warrant more comprehensive investigations in the systems biology perspective. In MicroRNA and Cancer: Methods and Protocols, internationally renowned experts provide the latest miRNA knowledge, the various techniques and methodologies currently available for cancer research application. Ranging from the fundamental concepts to practical applications, this book presents: • Overview of microRNA biogenesis, computational prediction of new miRNAs in the cancer genome, and miRNA-based therapeutic approaches for cancer treatment • Detailed experimental protocols in miRNA detection with novel and high-throughput technology, miRNA library cloning, miRNA epigenetic regulation, and miRNA pathway study • Stepwise computational and bioinformatic procedures for miRNA complex networks in cancer genomes with a variety of softwares and programs • Cross-cited notes on troubleshooting and avoiding known pitfalls Authoritative and cutting-edge, MicroRNA and Cancer: Methods and Protocols serves researchers with the basic principles of experimental and computational methods for microRNA study in cancer research and provides a firm grounding for those who wish to further develop their own applications and tailor them to their own specific research needs.

Transcriptional and Translational Regulation of Stem Cells

Transcriptional and Translational Regulation of Stem Cells Book
Author : Gary Hime,Helen Abud
Publisher : Springer Science & Business Media
Release : 2013-05-22
ISBN : 9400766211
Language : En, Es, Fr & De

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Book Description :

This volume describes the latest findings on transcriptional and translational regulation of stem cells. Both transcriptional activators and repressors have been shown to be crucial for the maintenance of the stem cell state. A key element of stem cell maintenance is repression of differentiation factors or developmental genes – achieved transcriptionally, epigenetically by the Polycomb complex, and post-transcriptionally by RNA-binding proteins and microRNAs. This volume takes two approaches to this topic – (1) illustrating the general principles outlined above through a series of different stem cell examples – embryonic, iPS and adult stem cells, and (2) describing several molecular families that have been shown to have roles in regulation of multiple stem cell populations.