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Microcirculation

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Microcirculation

Microcirculation Book
Author : Ronald F. Tuma,Walter N. Duran,Klaus Ley
Publisher : Academic Press
Release : 2011-04-28
ISBN : 9780080569932
Language : En, Es, Fr & De

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Book Description :

This reference is a volume in the Handbook of Physiology, co-published with The American Physiological Society. Growth in knowledge about the microcirculation has been explosive with the field becoming fragmented into numerous subdisciplines and subspecialties. This volume pulls all of the critical information into one volume. Meticulously edited and reviewed. Benefit: Provides investigators a unique tool to explore the significance of their findings in the context of other aspects of the microcirculation. In this way, the updated edition has a direct role in helping to develop new pathways of research and scholarship Highlights the explosive growth in knowledge about the microcirculation including the biology of nitric oxide synthase (NOS), endothelial cell signaling, angiogenesis, cell adhesion molecules, lymphocyte trafficking, ion channels and receptors, and propagated vasomotor responses. Benefit: Microcirculatory biology has become fragmented into numerous sub-disciplines and subspecialties, and these reference reintegrates the information in one volume

Microcirculation and Insulin Resistance

Microcirculation and Insulin Resistance Book
Author : Nicolas Wiernsperger,Eliete Bouskela,Luiz Guilherme Kraemer-Aguiar
Publisher : Bentham Science Publishers
Release : 2010-05-03
ISBN : 1608050572
Language : En, Es, Fr & De

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Book Description :

"Insulin resistance is the main factor involved in the occurrence of the metabolic syndrome and later development of type2 diabetes. Despite decades of research on hormone's target tissues and the identification of most diverse candidates, the factors resp"

Ion Channels and Calcium Signaling in the Microcirculation

Ion Channels and Calcium Signaling in the Microcirculation Book
Author : William F. Jackson
Publisher : Academic Press
Release : 2020-06
ISBN : 0128200901
Language : En, Es, Fr & De

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Book Description :

Ion Channels and Calcium Signaling in the Microcirculation, Volume 85, the latest release in the Current Topics in Membranes series, highlights the latest advances in the expression and function of ion channels and calcium signaling in vascular smooth muscle and endothelial cells in resistance arteries, arterioles and capillaries, critical components of microcirculation, the business end of the cardiovascular system. Leading experts have contributed chapters, including Smooth muscle ion channels and calcium signaling in the regulation of striated muscle arteriolar tone; Endothelial KIR channels as a key component of shear stress-induced mechanotransduction; Endothelial TRPV4 channels and vasodilator reactivity, and much more. Additional sections cover cerebral capillary endothelial TRPA channels and the regulation of blood flow; Endothelial mineralocorticoid receptors and the regulation of TRPV4 function in cerebral parenchymal arterioles in hypertension; Subcellular calcium signaling and myogenic tone development in the retinal microcirculation; Microvascular KIR channels: Basis, properties and regulation by lipid and hemodynamic forces, Ion channels and calcium signaling in capillary endothelial cells; Ion channels and calcium signaling in bladder arterioles and resistance arteries, and Myoendothelial feedback and endothelial IKCa and sKCa channels.

The Pathophysiology of the Microcirculation

The Pathophysiology of the Microcirculation Book
Author : Nicholas A. Mortillaro,Aubrey E. Taylor
Publisher : CRC Press
Release : 1994-02-28
ISBN : 9780849345470
Language : En, Es, Fr & De

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Book Description :

This book is devoted to the pathophysiology of the microcirculation, an intensely studied area of the circulatory system. Featuring contributions from 29 top investigators in the field, the book begins with an introduction to the general structure of the normal microvascular system, with special emphasis on the characteristics of blood vessel segments collectively comprising the system. Significant areas covered in the book include angiogenesis, neoplasias, hypertension, shock, ischemia/reperfusion, diabetes, immunologic injury, and thermal injury. It also covers the effects of aging and environmental factors on the microcirculation-topics not often examined in depth. More than 80 figures and tables illustrate key concepts throughout the book.

Organ Microcirculation

Organ Microcirculation Book
Author : H. Ishii,M. Suematsu,K. Tanishita,H. Suzuki
Publisher : Springer Science & Business Media
Release : 2006-03-16
ISBN : 4431271740
Language : En, Es, Fr & De

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Book Description :

The concept of microcirculation means not only the assembly of small vessels-those of less than 100 um in diameter, but also its functional circulatory and metabolic units. Its principal function is to permit the transfer of substances between the tissues and the circulation, making it a fundamental factor in disease processes, including the spread of cancer, delayed healing, circulatory shock, and complications of diabetes . Organ Microcirculation: A Gateway to Diagnostic and Therapeutic Interventions covers the latest developments in nano-biotechnology for microvascular interventions, gastroduodenal microcirculation and disease, liver microvascular research, cell adhesion and traffic in micmcirculation, and the sensing and bioregulation of gaseous molecules in microcirculation . It provides invaluable information for those engaged in microvascular research in the fields of pharmacology, physiology, gastroenterology, and bioengineering.

Microcirculation in Cancer Metastasis

Microcirculation in Cancer Metastasis Book
Author : F. William Orr,Michael R. Buchanan,Leonard Weiss
Publisher : CRC Press
Release : 1991-07-25
ISBN : 9780849361548
Language : En, Es, Fr & De

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Book Description :

Although mechanisms involved in the spread of cancer have been the subject of a major research endeavor over the past decade, metastatic tumors still account for significant clinical morbidity and the failure of cancer treatment. Not only are the vascular pathways the most common route for the dissemination of cancer cells, but interactions between the cells and the circulation act as important rate-regulators for the metastatic process. This authoritative, multi-authored volume addresses the importance of microcirculation in cancer metastasis. The book begins with up-to-date reviews on the biology of endothelial cells and the structure and physiology of the normal and tumor microcirculations, and then emphasizes interactions between components of the microcirculation and cancer cells. Metastasis is discussed through chapters exploring the entry of cancer cells into the circulation, the biophysics and morphology of cancer cell traffic and arrest, interactions with host cells and the basement membranes, and angiogenesis. This fascinating book will interest oncologists, pathologists, and students of metastasis or the microcirculation.

Microcirculation in Chronic Venous Insufficiency

Microcirculation in Chronic Venous Insufficiency Book
Author : K. Messmer
Publisher : Karger Medical and Scientific Publishers
Release : 1999
ISBN : 3805568215
Language : En, Es, Fr & De

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Book Description :

TThis volume contains expert articles on the physiology and function of the microvascular and microlymphatic systems, the physiology of microvascular fluid filtration and reabsorption, interactions between blood cells and the microvascular endothelium, and molecular mechanisms of leukocyte activation. The therapeutic goals in chronic venous insufficiency include reduction of postischemic leukocyte-endothelial cell interaction, repair of microvascular barrier and improvement of microlymphatic drainage. In addition to measures to counteract inflammatory reactions elicited by local ischemia, surgical procedures such as transplantation of lymph vessels and subfascial division of perforating veins by an endoscopic approach are reviewed. Written by leading experts in the field, this book provides the first synopsis of the role of microcirculatory disturbances in chronic venous insufficiency. It will be of particular interest to phlebologists, angiologists, dermatologists, gerontologists, vascular, plastic and reconstructive surgeons, and general physicians.

Microcirculation

Microcirculation Book
Author : Maria Dorobantu,Lina Badimon
Publisher : Springer Nature
Release : 2019-11-04
ISBN : 303028199X
Language : En, Es, Fr & De

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Book Description :

This comprehensive reference book of coronary microcirculation broadly covers theoretical aspects, clinical cases and therapeutic considerations from an innovative perspective. Topics covered include: ischemic heart disease, silent cerebral damage, heart failure, left ventricular hypertrophy arrhythmias, and cerebral and renal microcirculation. Microcirculation: From Bench to Bedside underlines the clinical importance of addressing coronary microcirculation with relevant clinical examples that are often encountered by practitioners. It therefore provides a critical resource on microcirculation for both specialist and non-specialist practitioners.

Microcirculation Imaging

Microcirculation Imaging Book
Author : Martin J. Leahy
Publisher : John Wiley & Sons
Release : 2012-05-22
ISBN : 3527651217
Language : En, Es, Fr & De

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Book Description :

Adopting a multidisciplinary approach with input from physicists, researchers and medical professionals, this is the first book to introduce many different technical approaches for the visualization of microcirculation, including laser Doppler and laser speckle, optical coherence tomography and photo-acoustic tomography. It covers everything from basic research to medical applications, providing the technical details while also outlining the respective strengths and weaknesses of each imaging technique. Edited by an international team of top experts, this is the ultimate handbook for every clinician and researcher relying on microcirculation imaging.

Microcirculation

Microcirculation Book
Author : Richard Effros
Publisher : Elsevier
Release : 2012-12-02
ISBN : 0323155499
Language : En, Es, Fr & De

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Book Description :

Microcirculation: Current Physiologic, Medical, and Surgical Concepts is based primarily on a course and a series of lectures presented at a congress on microcirculation held at the University of California in August 1979. The book gives an overview of the concepts regarding the structure and properties of small vessels, a topic mostly read only in specialized journals. The primary focus of the text is on the function and dysfunction of small blood vessels. Three major parts comprise the text. Part I discusses the morphology, physiology, and pharmacology of circulation, and Part II presents the dynamics or role of the microcirculation in the study of diabetes. Finally, Part III discusses also the role of microcirculation in disease states, particularly hemoconcentration. The book will provide much information to researchers and students in the fields of biology, medicine, physiology, and pharmacology.

Mikrozirkulation Microcirculation

Mikrozirkulation   Microcirculation Book
Author : M. Boutet,U. Fuchs,P. Gaethgens,O.H. Gauer,F. Hammersen,D.L. Heene,I. Hüttner,K. Kirsch,J. Lang,H.G. Lasch,D.W. Lübbers,R.G. Mason,R. Poche,G. Rona,H. Schmid-Schönbein,D.E. Sharp
Publisher : Springer-Verlag
Release : 2013-03-07
ISBN : 3642663907
Language : En, Es, Fr & De

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Book Description :

GOETHE bemerkt in seinen "Maximen und Reflexionen": "Zur Verewigung des Irrtums tragen die Werke besonders bei, die enzyklopädisch das Wahre und Falsche des Tages überliefern. Hier kann die Wissenschaft nicht bearbeitet werden, sondern was man weiß, glaubt, wähnt, wird aufgenommen; deswegen sehen solche Werke nach fünfzig Jahren gar wunderlich aus. " Diese kritische Einstellung zum "Handbuch" hatte ich vor Augen, als ich mit den Vorbereitun gen für den Band "Mikrozirkulation" begann. Den Mut, dennoch ein nicht abgeschlossenes Werk vorzulegen, begründe ich damit, daß die Sorge, zur Ver ewigung des Irrtums beizutragen, für das heutige Verständnis der Wissenschaft nicht mehr gilt. Zwar halten manche Forscher daran fest - und das ist auch ihr gutes Recht - zu versuchen, einmal Erarbeitetes mit neuen Methoden oder durch ergänzende Befunde zu bestätigen und zu erhärten, im Grunde geben sie aber durch ihre weiteren Arbeiten zu - und sie sind auch darauf gefaßt -, daß jeder einzelne Befund, jede Grundlage und jede entwickelte Hypothese sich als falsch erweisen kann. Diese skeptische Grundhaltung der Forscher gegen über den Ergebnissen der Wissenschaft rührt daher, daß sie einerseits nicht mehr glauben, sich mit Hilfe der Wissenschaft jemals der Wahrheit direkt versi chern zu können, andererseits können sie Glauben im Sinne des Fest-für-wahr Haltens in der Wissenschaft nicht gelten lassen. In dem Bestreben, die Dinge kritisch und realistisch zu sehen, bemühen sich die theoretischen, d. h.

The Physiology and Pharmacology of the Microcirculation

The Physiology and Pharmacology of the Microcirculation Book
Author : Nicholas A. Mortillaro
Publisher : Elsevier
Release : 2013-10-22
ISBN : 1483262081
Language : En, Es, Fr & De

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Book Description :

The Physiology and Pharmacology of the Microcirculation, Volume 2, discusses the microcirculatory function of specific organ systems. The first volume of The Physiology and Pharmacology of the Microcirculation presented some general aspects of microcirculatory function and then concentrated on the microcirculation of a specific organ system, namely, brain, eye, heart, and kidneys. This second and final volume continues the presentation of microcirculatory function of specific organ systems. The book begins with a chapter on the microcirculation of the lungs, with a description of its microcirculatory features and current methods of study. This is followed by separate chapters on the microcirculation of the splanchnic organs. These include the stomach, emphasizing hemodynamics, tissue oxygenation, and control of blood flow; the small and large intestine. Subsequent chapters deal with the microcirculatory responses of both the liver and spleen to different physiological and pharmacological challenges; the microcirculation of the skin, with emphasis on human microcirculation; normal and abnormal microcirculatory dynamics in skeletal muscle; microcirculation of bone; and microcirculation of the salivary glands and exocrine pancreas. The final chapter presents a selective review of pathological events involving the microcirculation, with the emphasis directed toward human diseases.

Microcirculation in Circulatory Disorders

Microcirculation in Circulatory Disorders Book
Author : Hisao Manabe,Benjamin W. Zweifach,Konrad Messmer
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 4431680780
Language : En, Es, Fr & De

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Book Description :

This book presents recent progress in microvascular disorders including cerebral, myocardial and peripheral tissue ischemia, multiple organ failure and gastroenterological disorders. Knowledge of microcirculation is essential in order to understand thoroughly the mechanism of organ disorders. This book successfully elucidates the pathophysiologic significance of microcirculation in ischemia and other diseases. It is useful for basic researchers and clinicians who are interested in the early diagnosis and prevention of cardiovascular diseases as well as in the mechanism of circulatory disorders.

Microcirculation in Fractal Branching Networks

Microcirculation in Fractal Branching Networks Book
Author : Tatsuhisa Takahashi
Publisher : Springer Science & Business Media
Release : 2013-09-17
ISBN : 4431545085
Language : En, Es, Fr & De

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Book Description :

This book presents a new method for analyzing the structure and function of the biological branching systems of fractal trees, with a focus on microcirculation. Branching systems in humans (vascular and bronchial trees) and those in the natural world (plants, trees, and rivers) are characterized by a fractal nature. To date, fractal studies have tended to concentrate on fractal dimensions, which quantify the complexity of objects, but the applications for practical use have remained largely unexplored. This book breaks new ground with topics that include the human retinal microcirculatory network, oxygen consumption by vascular walls, the Fåhraeus-Lindqvist effect, the bifurcation exponent, and the asymmetrical microvascular network. Readers are provided with simple formulas to express functions and a simulation graph with in vivo data. The book also discusses the mechanisms regulating blood flow and pressure and how they are related to pathological changes in the human body. Researchers and clinicians alike will find valuable new insights in these pioneering studies.

Microcirculation as Related to Shock

Microcirculation as Related to Shock Book
Author : David Shepro
Publisher : Elsevier
Release : 2012-12-02
ISBN : 0323157130
Language : En, Es, Fr & De

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Book Description :

Microcirculation as Related to Shock contains the proceedings of the 1967 Conference on the Microcirculation as Related to Shock held at Boston University. Contributors address reduced blood flow in the microcirculation and microcirculatory hypoperfusion as the focal point of shock. They also review significant progress in shock research, basic cardiovascular physiology, and cognate interdisciplinary fields. This volume is organized into four sections encompassing 26 chapters and begins with an overview of organs and systems involved in shock, including splanchnic circulation, regulatory mechanisms in shock, and microcirculatory studies in hypotension. The next chapters explore the causative factors that produce the state of low blood flow as found in shock, and whether microcirculatory hypoperfusion in humans can be prevented and treated. The book also discusses whether microcirculatory hypoperfusion can be measured in the patient and concludes with an assessment of promising avenues for further research, emphasizing the measurement of blood viscosity, shear stress, and rheological factors as indices of the degree of hypotension. This book is a valuable source of information for physiologists, biologists, and pathologists, as well as those involved in the medical sciences.

Inflammation and the Microcirculation

Inflammation and the Microcirculation Book
Author : D. Neil Granger,Elena Senchenkova
Publisher : Biota Publishing
Release : 2010-06-01
ISBN : 1615041664
Language : En, Es, Fr & De

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Book Description :

The microcirculation is highly responsive to, and a vital participant in, the inflammatory response. All segments of the microvasculature (arterioles, capillaries, and venules) exhibit characteristic phenotypic changes during inflammation that appear to be directed toward enhancing the delivery of inflammatory cells to the injured/infected tissue, isolating the region from healthy tissue and the systemic circulation, and setting the stage for tissue repair and regeneration. The best characterized responses of the microcirculation to inflammation include impaired vasomotor function, reduced capillary perfusion, adhesion of leukocytes and platelets, activation of the coagulation cascade, and enhanced thrombosis, increased vascular permeability, and an increase in the rate of proliferation of blood and lymphatic vessels. A variety of cells that normally circulate in blood (leukocytes, platelets) or reside within the vessel wall (endothelial cells, pericytes) or in the perivascular space (mast cells, macrophages) are activated in response to inflammation. The activation products and chemical mediators released from these cells act through different well-characterized signaling pathways to induce the phenotypic changes in microvessel function that accompany inflammation. Drugs that target a specific microvascular response to inflammation, such as leukocyte-endothelial cell adhesion or angiogenesis, have shown promise in both the preclinical and clinical studies of inflammatory disease. Future research efforts in this area will likely identify new avenues for therapeutic intervention in inflammation.

An Introduction to Microcirculation

An Introduction to Microcirculation Book
Author : M.P. Wiedeman
Publisher : Elsevier
Release : 2012-12-02
ISBN : 032315946X
Language : En, Es, Fr & De

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Book Description :

An Introduction to Microcirculation is written in response to the need for a book containing the most basic information about microcirculation. The book aims to consolidate information gained from the numerous vascular beds that have been used for in vivo microscopic observations, to note the similarities and differences in architecture and function, to reveal the origin of certain terms and concepts, and to discuss hemodynamics of the micro vessels. The book is divided into three parts. Part 1 covers a historical introduction to the study; general anatomical comparisons; the microvasculature of specific organs and tissues; and methods of preparation of tissues for microscopic observation. Part 2 discusses factors that are involved in this process and the exchange in the microcirculation. Part 3 explores the hemodynamics in the microcirculation and quantitative techniques for measurement of velocity and blood pressure. The text is for medical students, graduate students, clinicians, and young investigators who wish to have a greater knowledge on microcirculation and the concepts behind it.

Cardiovascular Physiology Microcirculation and Capillary Exchange

Cardiovascular Physiology  Microcirculation and Capillary Exchange Book
Author : A. G. B. Kovàch,J. Hamar,L. Szabó
Publisher : Elsevier
Release : 2013-10-22
ISBN : 1483189953
Language : En, Es, Fr & De

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Book Description :

Advances in Physiological Sciences, Volume 7: Cardiovascular Physiology: Microcirculation and Capillary Exchange is a collection of papers that tackles the advances in the understanding of microcirculation and capillary exchange. The text first details the coordination of microcirculatory function with oxygen demand in skeletal muscle, and then proceeds to discussing the role of intravascular pressure in the regulation of the microcirculation. Next, the selection covers the circulatory actions of prostacyclin and thromboxane, along with the routes of transcapillary transport. The last two parts of the text deal with the lymphatic system and blood-brain barrier. The book will be of great interest to health professionals, particularly cardiologists and cardiovascular surgeons.

Clinical Investigation of the Microcirculation

Clinical Investigation of the Microcirculation Book
Author : John E. Tooke,L.H. Smaje
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 1461323355
Language : En, Es, Fr & De

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Book Description :

In 1628 William Harvey published his discovery of the existence of the microcirculation which he deduced from careful anatomical and physiological study. Thirty-three years later, Malpighi confirmed the presence of capillaries through direct microscopical observation. Subsequent scientific advance has been slow, and in view of the fact that microvascular in the genesis and expression of many pathophysiology may be implicated diseases, our know ledge of human microvascular function is surprisingly limited. This ignorance attests to the difficulty of studying something that is both minute and inaccessible without disturbing the quantity that is being measured. In the last fifteen years, however, direct techniques have been developed for studying human microvascular pressure, flow and permeability. These methods have provided new insights into human microvascular function in health and disease. At the same time there has been a steady growth of new indirect techniques based on a w ide range of physical principles that reflect some or other aspect of microvascular function.

Morphofunctional Aspects of Tumor Microcirculation

Morphofunctional Aspects of Tumor Microcirculation Book
Author : Domenico Ribatti
Publisher : Springer Science & Business Media
Release : 2012-09-28
ISBN : 9400749368
Language : En, Es, Fr & De

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Book Description :

Blood vessels of tumors display many structural and functional abnormalities. Their unusual leakiness, potential for rapid growth and remodeling, and expression of distinctive surface molecules mediate the dissemination of tumor cells in the bloodstream and maintain the tumor microenvironment. Like normal blood vessels, they consist of endothelial cells, mural cells and their enveloping basement membrane. Common features, irrespective of their origin, size and growth pattern, are absent hierarchy, formation of large-caliber sinusoidal vessels, markedly heterogeneous density, increased permeability, decreased and abnormal pericyte-endothelial cell adhesion, irregular basement membrane structure, and the incorporation of bone-marrow-derived endothelial progenitor cells in the microvasculature. A number of specific tumor endothelial markers have been identified, as well as chromosomal abnormalities. These markers may be used to deliver drugs specifically and selectively to the tumor microvasculature.