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Gut Microbiota

Gut Microbiota Book
Author : Alper Evrensel,Barış Önen Ünsalver
Publisher : BoD – Books on Demand
Release : 2018-12-12
ISBN : 1789848148
Language : En, Es, Fr & De

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Book Description :

The gut-brain axis has gained considerable attention from different branches of the scientific community in recent years. In this book, scientists from different disciplines present current scientific knowledge on the topic. The interaction between the prokaryote and eukaryote cells stimulates the evolutionary processes, and results in various systemic illnesses such as neuropsychiatric disorders and may help the continuity of health. Nature has provided us with healthy food that builds our pharmacy. This natural pharmacy store may help the body's healing processes through its effects on gut microbiota and the immune system. This book aims to provide the reader with detailed analyses of the current scientific knowledge on the gut-brain axis and its relation with health and disease. We hope that the reader benefits from the presented material.

Microbiota Brain Axis

Microbiota Brain Axis Book
Author : Jane A. Foster,Rochellys Diaz Heijtz
Publisher : Academic Press
Release : 2020-12-15
ISBN : 9780128148006
Language : En, Es, Fr & De

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Book Description :

Microbiota Brain Axis: A Neuroscience Primer provides neuroscience researchers with a comprehensive guide on how to conduct effective microbiota-brain research, understand the appropriate methodologies, and collect and analyze microbiota data. The book begins with an introduction to the importance of the microbiota-brain communication in development and how microbiota impact neurodevelopmental disorders, mental health and neurodegeneration. In addition, the book discusses advances in microbiota analysis tools and techniques for neuroscience related research. Reviews the many approaches to manipulating the microbiota in animal studies - including the use of germ-free animals, antibiotics and diet - and covers the strengths and limitations of each Outlines available microbiota research tools, such as 16S sequencing and shot-gun metagenomics Provides a comprehensive guide to analyzing microbiota-related data and the many choices for bioinformatics

Microbial Endocrinology The Microbiota Gut Brain Axis in Health and Disease

Microbial Endocrinology  The Microbiota Gut Brain Axis in Health and Disease Book
Author : Mark Lyte,John F. Cryan
Publisher : Springer
Release : 2014-07-05
ISBN : 1493908979
Language : En, Es, Fr & De

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Book Description :

The field of microbial endocrinology is expressly devoted to understanding the mechanisms by which the microbiota (bacteria within the microbiome) interact with the host (“us”). This interaction is a two-way street and the driving force that governs these interactions are the neuroendocrine products of both the host and the microbiota. Chapters include neuroendocrine hormone-induced changes in gene expression and microbial endocrinology and probiotics. This is the first in a series of books dedicated to understanding how bi-directional communication between host and bacteria represents the cutting edge of translational medical research, and hopefully identifies new ways to understand the mechanisms that determine health and disease.​

The Gut Brain Axis

The Gut Brain Axis Book
Author : Niall Hyland,Catherine Stanton
Publisher : Academic Press
Release : 2016-05-13
ISBN : 0128025441
Language : En, Es, Fr & De

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Book Description :

The Gut-Brain Axis: Dietary, Probiotic, and Prebiotic Interventions on the Microbiota examines the potential for microbial manipulation as a therapeutic avenue in central nervous system disorders in which an altered microbiota has been implicated, and explores the mechanisms, sometimes common, by which the microbiota may contribute to such disorders. Focuses on specific areas in which the microbiota has been implicated in gut-brain communication Examines common mechanisms and pathways by which the microbiota may influence brain and behavior Identifies novel therapeutic strategies targeted toward the microbiota in the management of brain activity and behavior

Emotional Gut the Relation Between Gut Microbiome and Mental Health

Emotional Gut  the Relation Between Gut Microbiome and Mental Health Book
Author : Inu00eas Figueiredo
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The central nervous system and the human gastrointestinal tract are connected via the brain-gut axis, which involves bidirectional communication via neural, endocrine and immune pathways. It has recently been discovered that this communication also involves interactions with the intestinal microbiota, which release immune activating and other signaling molecules that may play an important role in regulating the brain and subsequent behaviour. Since then, it has been found that alterations in the gut microbiota-brain-axis may be implicated in stress-related disorders such as depression and anxiety, neurodevelopmental disorders such as autism, and in cognitive functioning. This discoveries have provided the basis for development of new therapeutic approaches, through the modulation of the microbiota- gut-brain axis by means of prebiotic and probiotic administration. Psychobiotics are a new class of probiotics which, when ingested, confer mental health benefits through interactions with the microbiota-gut-brain axis.MATERIALS AND METHODSNon-systematic review of the literature published in Pubmed/Medline database, using the following keywords:

Microbiome gut brain axis

Microbiome gut brain axis Book
Author : R.Z. Sayyed,Mahejibin Khan
Publisher : Springer
Release : 2021-07-31
ISBN : 9789811616259
Language : En, Es, Fr & De

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Book Description :

The book highlights the importance of prebiotics, probiotics and synbiotics in the signalling mechanism between gut microbiota and brain, also referred to as the gut-brain axis. A stable gut microbiota is essential for normal gut physiology and overall health, since it assists in proper signalling along the brain–gut axis. The book describes how the cross talks between gut microbiota and brain, not only regulate gastro-intestinal functions but also ensure proper functioning of cognitive behaviour and immunological functions. The various chapters describe probiotic microorganisms that colonize gastrointestinal tract and provide an array of health benefits to the host. It further elaborates about certain non-digestible oligosaccharides (prebiotics) are easily fermented by specialist microbes in the gut, to produce health-promoting metabolites and inhibit the growth of pathogenic bacteria. This book is useful for students, researchers and scientists in the field of microbiology, food science and nutrition. It is also meant for industry experts involved in developing nutraceuticals.

Gut Microbiota Its Modifications and the Gut brain Axis

Gut Microbiota  Its Modifications and the Gut brain Axis Book
Author : Anonim
Publisher : Unknown
Release : 2021
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Gut Microbiota Its Modifications and the Gut brain Axis book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The Complex Interplay Between Gut Brain Gut Liver and Liver Brain Axes

The Complex Interplay Between Gut Brain  Gut Liver  and Liver Brain Axes Book
Author : Cristina Stasi
Publisher : Academic Press
Release : 2021-04-06
ISBN : 0128219289
Language : En, Es, Fr & De

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Book Description :

The Complex Interplay Between Gut–Brain, Gut–Liver, and Liver–Brain Axes provides current and wide-ranging information in the field of gastrointestinal, liver, and brain interactions that can be used in resolving important clinical issues. This book is systematically split into three distinct sections. The first section introduces the pathophysiology of the gut–brain connection, including the causative effect of the interactions between the gut and brain in gastrointestinal and psychiatric/neurological disorders, and the role of serotonin and its pathways in gastrointestinal disorders. The second section examines the pathophysiology of the gut–liver connection along with the interactions between gut microbiota and liver in chronic liver diseases, with special focus on the role of serotonin and its pathways in hepatic fibrogenesis. Finally, the third section describes the pathophysiology of the liver–brain connection, including the role of gut microbiota in hepatic encephalopathy, as well as dietary and therapeutic interventions that target the gut microbiome. Provides current and wide-ranging knowledge in the field of gastrointestinal, liver, and brain interactions. Resolves important clinical issues concerning gut, liver, and brain interactions. Demonstrates advances in the understanding of the pathophysiology of gastrointestinal and liver diseases.

The Possible Role of the Microbiota gut brain axis in Autism Spectrum Disorder

The Possible Role of the Microbiota gut brain axis in Autism Spectrum Disorder Book
Author : Piranavie Srikantha
Publisher : Unknown
Release : 2019
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download The Possible Role of the Microbiota gut brain axis in Autism Spectrum Disorder book written by Piranavie Srikantha, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Role of Nutraceuticals in Modulation of Gut Brain Axis in Elderly Persons

Role of Nutraceuticals in Modulation of Gut Brain Axis in Elderly Persons Book
Author : Ana-Maria Enciu
Publisher : Unknown
Release : 2018
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

A rather new and somewhat unusual concept connects brain functions to gut microbiota. It is called "gut-brain axis" (or "microbiota-gut-brain axis") and states that probiotics consumption and a healthy gut microbiota positively influence brain functions related to behavior and cognition. Synergistic with a low chronic grade peripheral inflammation, this faulty barrier exposes the aged brain to negative extra-cerebral signals. Given the quasi-constant failure of pharmacological treatments in neurodegenerative diseases, increased interest is directed toward allopathic medicine, including dietary supplements. Interplay between gut microbiota and central nervous system by immune, neural and metabolic pathways is being explored as a possible modulator of cognitive impairment and behavior disorders. In elderly persons, this axis has been reported to be altered, contributing to systemic inflammation and was also indicated as a possible marker for early frailty in younger population. Currently, there are several clinical trials addressing the relationship between gut microbiota and central nervous system psychiatric disorders and at least one directly investigating whether there is a correlation between composition of gut microbiome, permeability of intestinal barrier and systemic inflammation in patients with dementia. This chapter discusses evidence-based data on positive modulation of gut-brain axis to alleviate behavior and cognition alterations in the elderly.

Nod1 Nod2 Receptors Modulate the Microbiota Gut Brain Axis

Nod1 Nod2 Receptors Modulate the Microbiota Gut Brain Axis Book
Author : Melinda A. Schneider
Publisher : Unknown
Release : 2015
ISBN : 9781321910902
Language : En, Es, Fr & De

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Book Description :

The association between intestinal diseases, mood disorders and cognitive deficits is increasingly recognized. Previous studies from our lab suggest that chronic intestinal diseases, such as infection with an enteric pathogen, in combination with an acute psychological stressor (water avoidance stress [WAS]), can induce anxiety-like behavior and memory defects in mice. In our current study, we hypothesized that nucleotide binding oligomerization domain (Nod) receptors, as important modulators of homeostasis between the host immune system and the gut microbiota, are integral regulators of the microbiota-gut-brain (MGB) axis. Using Nod1/Nod2 double knockout (NodDKO) mice, we performed behavioral testing, qPCR analysis of stool bacterial DNA, and serum corticosterone analysis. Compared to wild type (WT) controls (C57BL/6), NodDKO mice displayed anxiety-like behaviors (light/dark box test, p

The Microbiome and the Brain

The Microbiome and the Brain Book
Author : David Perlmutter
Publisher : CRC Press
Release : 2019-12-06
ISBN : 1351235680
Language : En, Es, Fr & De

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Book Description :

Brain related disorders are among the most challenging health issues of our time. The development of effective therapeutic and preventive strategies for these disorders relies on a comprehensive understanding of the underlying causative mechanisms. And, until recently, these mechanisms have remained somewhat elusive. The newly discovered pivotal role of the intestinal microbiome in brain health, functionality, and resistance to disease is revolutionizing neuroscience. The Microbiome and the Brain, through the contributions of some of the most forward thinking researchers and clinicians in the field, comprehensively reveals the leading edge of our understanding of the fundamental role of gut microbes and their metabolites in a wide array of seemingly diverse brain issues including Alzheimer’s disease, autism, multiple sclerosis, and mood disorders. In addition, mechanisms defining these relationships are explored along with a presentation of the state-of-the-art as it relates to interpretation of relevant laboratory assessments. Finally, novel therapeutic opportunities, derived from this exciting science are presented. Readers will learn: The highly validated relationship between alterations of gut microbes and their metabolites, and risk for Alzheimer’s disease. The important link between autism and intestinal dysbiosis. Appropriate interpretation of available laboratory assessments of the intestinal microbiome. The potential role of fecal microbial transplant in neurological diseases. The influence of diet and other lifestyle choices on the microbiome as it relates to brain health and functionality.

The Microbiome

The Microbiome Book
Author : Anonim
Publisher : Academic Press
Release : 2020-11-01
ISBN : 0128207981
Language : En, Es, Fr & De

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Book Description :

The Microbiome, Volume 176, assembles known facts and provides guidance for their implementation on topics relating to associations between the gut microbiome and personality traits, depression, anxiety, autism, schizophrenia, cognition, dementia and neurodegeneration. Additionally, this volume considers the influence of the maternal microbiome on brain development, with chapters covering Intervention, prevention, and the brain: prebiotics, probiotics, and fecal transplants, The microbiota-gut-brain axis: focus on the fundamental communication pathways, and Microbiome composition and locations. Provides a comprehensive review of the bidirectional interactions between gut microbes and the brain Includes data across the lifespan Focuses on microbiome related therapies with broad appeal within, and beyond, the medical and scientific community

The Interplay of Microbiome and Immune Response in Health and Diseases

The Interplay of Microbiome and Immune Response in Health and Diseases Book
Author : Gwendolyn Barcel´o-Coblijn,Amedeo Amedei
Publisher : MDPI
Release : 2019-11-06
ISBN : 3039216465
Language : En, Es, Fr & De

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Book Description :

[Increasing evidence suggests that microbiota and especially the gut microbiota (the microbes inhabiting the gut including bacteria, archaea, viruses, and fungi) plays a key role in human physiology and pathology. Recent findings indicate how dysbiosis—an imbalance in the composition and organization of microbial populations—could severely impact the development of different medical conditions (from metabolic to mood disorders), providing new insights into the comprehension of diverse diseases, such as IBD, obesity, asthma, autism, stroke, diabetes, and cancer. Given that microbial cells in the gut outnumber host cells, microbiota influences human physiology both functionally and structurally. Microbial metabolites bridge various—even distant—areas of the organism by way of the immune and hormone system. For instance, it is now clear that the mutual interaction between the gastrointestinal tract and the brain (gut–brain axis), often involves gut microbiota, indicating that the crosstalk between the organism and its microbial residents represents a fundamental aspect of both the establishment and maintenance of healthy conditions. Moreover, it is crucial to recognize that beyond the intestinal tract, microbiota populates other host organs and tissues (e.g., skin and oral mucosa). We have edited this eBook with the aim of publishing manuscripts focusing on the impact of microbiota in the development of different diseases and their associated treatments.]

Do You Have Guts to be Happy

Do You Have Guts to be Happy  Book
Author : Annick V Hartstra
Publisher : Unknown
Release : 2020
ISBN : 9789464161519
Language : En, Es, Fr & De

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Book Description :

Download Do You Have Guts to be Happy book written by Annick V Hartstra, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

15 FOOD CREATES MOOD THE GUT BRAIN MICROBIOTA AXIS AND DEPRESSION

15   FOOD CREATES MOOD  THE GUT BRAIN MICROBIOTA AXIS AND DEPRESSION Book
Author : Sara Rodrigues
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

OBJECTIVESThis review aims to shed light on the impact of gut microbiome on mood disorders, particularly depression, as well as to precise which factors influencing gut-brain signaling could be manipulated for better mental health management.BACKGROUND AND AIMSA constant bi-directional communication is known to take place between the gut and the brain. This interaction is referred to in the literature as the gut-brain-microbiota axis and may be key in triggering mood disorders. It is our aim to understand how microbiome respond to external factors and how managing gut bacteria might be useful as a potential therapeutic approach, as evidence on this matter remains limited.MATERIALS AND METHODSWe conducted a review on all articles concerning gut-brain-microbiome axis published in the last 5 years on PubMed database. A query comprising u201cpsychobiotics OR ((microbiome OR microbiota) AND depression)u201d was used, with full-text available articles being selected.RESULTSAn increasing number of studies suggest that gut microbiome exerts direct influence on mental health. As digestion of food by commensal bacteria living in the gut leads to neurotransmitters regulation and creation, gut bacteria affect brain function and human behavior. Recent studies show growing interest in the concept of psychobiotics - bacteria which when ingested may be beneficial to mental health. Its effects via enteric nervous system on emotional and cognitive functions seem to be prominent, with evidence suggesting potential antidepressant effects. CONCLUSIONSGut-brain-microbiome axis management and psychobiotics stand as promising therapeutic alternatives to treat mood disorders such as depression.

Skin Gut Breast Microbiota Axes

Skin Gut Breast Microbiota Axes Book
Author : Lorenzo Drago
Publisher : MDPI
Release : 2021-06-10
ISBN : 3036508988
Language : En, Es, Fr & De

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Book Description :

This book represents the latest research on microbiota axes, with a special focus on the gut-skin axis and the role of microbial breast bacteria on human health communication. This book also contains discussions of the microorganism-derived products that can directly or indirectly be signals for our organs and systems. Gut dysbiosis, representing a disruption of intestinal integrity, can create aberrant physiological conditions (including immunological disorders, intestinal stress, and anxiety-like behavior), as well as high serum levels of microbial metabolites increasing oxidative stress dysfunctions and generalized inflammation. Much research in this field has been carried out in animal models, and establishing whether those findings translate to humans will be crucial but challenging. On the other hand, several studies conducted on humans have evaluated the link between fecal microbiota composition and quality of life by recruiting thousands of participants. As well as identifying bacterial genera associated with higher quality of life, they carried out metagenomic analyses that indicated that the potential of microorganisms to synthesize certain active metabolites, and especially their interrelation, may also correlate with general wellbeing. It is clear that many axes can influence our lives; the most important include “the gut-brain axis” and the “skin-gut-breast axis”. Together, the studies presented in this book have laid the foundations for a better understanding of the effects of gut microbiota on skin and on our body in general. The mechanisms that underlie them may represent the ideal focus for the initial efforts to explore the relevance of these axes for human wellbeing.

Administration of Probiotics Normalizes Deficits in the Microbiota Gut Brain Axis Induced by DSS Colitis

Administration of Probiotics Normalizes Deficits in the Microbiota Gut Brain Axis Induced by DSS Colitis Book
Author : Kevin Huynh
Publisher : Unknown
Release : 2015
ISBN : 9781321892956
Language : En, Es, Fr & De

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Book Description :

Altered behavior and mood disorders, including anxiety, depression and cognitive dysfunction, are increasingly found to occur in the context of intestinal diseases such as inflammatory bowel disease (IBD) and negatively affect patient quality of life. The aim was to determine whether colonic inflammation precipitates behavioral deficits and whether these changes can be ameliorated by administration of probiotic organisms. Dextran sodium sulfate (DSS; 3% w/v) was administered to 6-7 week old C57BL/6 mice via drinking water for 5 days followed by either 3 days (8 d post-DSS; height of disease) or 9 days (14 d post-DSS; resolution of disease) of normal drinking water. A subset of mice was given probiotics (Lactobacillus rhamnosus [R0011] and L. helveticus [R0052]; 109 CFU/ml orally) starting 7 days prior to DSS and continuing until the end of the experiment. Changes in weight, colon length, behavior and microbiota were assessed. At 8 d post-DSS, weight loss and colonic shortening (both p

Microbiota Modulation of Behavior and Stress Responses

Microbiota Modulation of Behavior and Stress Responses Book
Author : Daniel J. Davis
Publisher : Unknown
Release : 2016
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The gut microbiota (GM) consists of a large microbial community whose collective set of genes encodes a vast array of functions. These microbes play a major role in many physiological processes within the host and are essential for survival. Ongoing research suggests that the GM is not only involved in gut physiology but may also have significant effects on brain function and behavior. The gut-brain axis is a bidirectional route of communication between the gastrointestinal tract and the central nervous system via neural, hormonal, and immunological pathways. The influence of the GM on gut-brain signaling is not well characterized. This dissertation research is aimed at investigating the role of the GM on stress-related brain function and behavior, as well as developing unique approaches for neuroimmune research. My first project was to investigate the influence the GM has on behavior in genetically identical mice. First, I isolated a subset of bacteria that colonize the ileum of mice from a particular vendor that has been shown to produce mice with very diverse GM. Isogenic colonies of mice were then generated with and without this subset of microbes and subjected to stress testing and behavioral analysis. From this study we were able to determine that the GM does play a significant role in stress-related brain function and behavior. However, dissecting out individual microbes and mechanisms by which the GM uses to communicate through the gut-brain axis proves to be a challenging task. In order to address some of these questions we began to explore more basic model systems, such as zebrafish. Zebrafish are an emerging high-throughput model system that exhibit many behaviors that have been correlated with those seen in human neurological disorders. The ability to easily control and manipulate the microbial environment in developing zebrafish makes neuroimmune research in zebrafish advantageous over other model systems. This research characterizes the ability of the GM to alter stress- and anxiety-related behavior and to mitigate stress responses in zebrafish. Furthermore, this research investigates potential pathways of communication to provide insight for mechanisms by which the GM influences the gut-brain axis. Since neurobehavioral research in zebrafish is an evolving field, my initial zebrafish project was to determine an optimal euthanasia agent for use in stress studies. This was crucial for eliminating euthanasia-induced stress responses which could confound results in our experiments. My next project was to generate gnotobiotic zebrafish in order to examine the significance of the GM in anxiety-related behavior and stress responses. Lastly, through bacterial metabolite experiments and probiotic studies, we began to investigate mechanisms of communication through the GM-gut-brain axis. This research sets the foundation for using zebrafish for neuroimmune research and will help elucidate the role that the GM plays in modulating brain function and behavior. A better understanding of the influence microbes have on the gut-brain axis will facilitate the potential for probiotic therapeutics targeting neurological disorders.

The microbiome Interactions with organ systems diet and genetics An Issue of Gastroenterology Clinics of North America Ebook

The microbiome  Interactions with organ systems  diet  and genetics  An Issue of Gastroenterology Clinics of North America  Ebook Book
Author : Rochellys Diaz Heijtz
Publisher : Elsevier Health Sciences
Release : 2019-08-09
ISBN : 0323679013
Language : En, Es, Fr & De

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Book Description :

In consultation with Consulting Editor, Dr. Alan Buchman, Dr. Rocheyllys Diaz Heijtz has put together a state-of the-art issue of the Gastroenterology Clinics of North America devoted to The Microbiome: Interactions with Organ Systems, Diet, and Genetics. Clinical review articles from expert authors are specifically devoted to the following: The Role of the Microbiome of o the Female Reproductive Tract on Health and Pregnancy; Eating Disorders and the Gut Microbiota; Maturation of the Infant Microbiome Community Structure and Function; Microbe-Host Interactions in Allergic Diseases; Emerging Role of the Gut Microbiota in Neurodevelopmental Disorders; Brain-Gut-Microbiota Axis and Mood Disorders; Brain-Gut-Microbiota and ADHD; The Microbiota-Gut-Brain Axis and Postpartum Depression; and The Microbiota and Pancreatic Cancer. Readers will come away with the latest information on the microbiome and how to incorporate the information into gut health for patients.