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The Complex Interplay Between Gut Brain Gut Liver and Liver Brain Axes

The Complex Interplay Between Gut Brain  Gut Liver  and Liver Brain Axes Book
Author : Cristina Stasi
Publisher : Academic Press
Release : 2021-04-06
ISBN : 0128219289
Language : En, Es, Fr & De

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Book Description :

The Complex Interplay Between Gut–Brain, Gut–Liver, and Liver–Brain Axes provides current and wide-ranging information in the field of gastrointestinal, liver, and brain interactions that can be used in resolving important clinical issues. This book is systematically split into three distinct sections. The first section introduces the pathophysiology of the gut–brain connection, including the causative effect of the interactions between the gut and brain in gastrointestinal and psychiatric/neurological disorders, and the role of serotonin and its pathways in gastrointestinal disorders. The second section examines the pathophysiology of the gut–liver connection along with the interactions between gut microbiota and liver in chronic liver diseases, with special focus on the role of serotonin and its pathways in hepatic fibrogenesis. Finally, the third section describes the pathophysiology of the liver–brain connection, including the role of gut microbiota in hepatic encephalopathy, as well as dietary and therapeutic interventions that target the gut microbiome. Provides current and wide-ranging knowledge in the field of gastrointestinal, liver, and brain interactions. Resolves important clinical issues concerning gut, liver, and brain interactions. Demonstrates advances in the understanding of the pathophysiology of gastrointestinal and liver diseases.

Fundamentals of Microbiome Science

Fundamentals of Microbiome Science Book
Author : Angela E. Douglas
Publisher : Princeton University Press
Release : 2018-05-01
ISBN : 0691160341
Language : En, Es, Fr & De

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Book Description :

An essential introduction to microbiome science, a new cutting-edge discipline that is transforming the life sciences This book provides an accessible and authoritative guide to the fundamental principles of microbiome science, an exciting and fast-emerging new discipline that is reshaping many aspects of the life sciences. Resident microbes in healthy animals--including humans—can dictate many traits of the animal host. This animal microbiome is a second immune system conferring protection against pathogens; it can structure host metabolism in animals as diverse as reef corals and hibernating mammals; and it may influence animal behavior, from social recognition to emotional states. These microbial partners can also drive ecologically important traits, from thermal tolerance to diet, and have contributed to animal diversification over long evolutionary timescales. Drawing on concepts and data across a broad range of disciplines and systems, Angela Douglas provides a conceptual framework for understanding these animal-microbe interactions while shedding critical light on the scientific challenges that lie ahead. Douglas explains why microbiome science demands creative and interdisciplinary thinking—the capacity to combine microbiology with animal physiology, ecological theory with immunology, and evolutionary perspectives with metabolic science. An essential introduction to a cutting-edge field that is revolutionizing the life sciences, this book explains why microbiome science presents a more complete picture of the biology of humans and other animals, and how it can deliver novel therapies for many medical conditions and new strategies for pest control.

The Microbiome in Prenatal and Neonatal Life

The Microbiome in Prenatal and Neonatal Life Book
Author : Josef Neu
Publisher : Academic Press
Release : 2021-01-18
ISBN : 0128206098
Language : En, Es, Fr & De

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Book Description :

The Microbiome in Prenatal and Neonatal Life clarifies that the microbiome in the maternal fetal unit and immediate changes that occur as new microbes are acquired postnatally play major roles in subsequent health and disease. Rapidly developing technologies for multi-omic analyses and systems biology are shifting paradigms in both scientific knowledge and clinical care with regard to this topic. In essence, we are changing the idea that newborns emerge from sterile environments. As such, in-utero colonization may have impacts on the development of immunity and metabolism that, with epigenetic modifications, will lead to diseases in later life. In addition, the microbial profile that develops during and after birth depends on mode of delivery, type of feeding (human milk versus formula), and various other environmental factors to which the newborn is exposed. Discusses the critical nonredundant timeframe in a newborn's life during which many factors drive immune and tissue maturation and influence the susceptibility to immune-mediated and other diseases in adult life Proves that the fetus and uterine membranes are exposed to not only microbes in close proximity but also to microbial products from metabolism of microbes in the mother Shows that since early life periods are a critical window for development, epigenetic and/or immunologic alterations may occur that can affect not only the infant during his/her lifetime but also subsequent generations Gives insight into factors that may affect the newborn microbiome and subsequent development

Handbook of Developmental Neurotoxicology

Handbook of Developmental Neurotoxicology Book
Author : William Slikker, Jr.,Merle G. Paule,Cheng Wang
Publisher : Academic Press
Release : 2018-01-04
ISBN : 0128093943
Language : En, Es, Fr & De

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Book Description :

Handbook of Developmental Neurotoxicology, Second Edition, provides a comprehensive view of the fundamental aspects of neurodevelopment, the pathways and agents that affect them, relevant clinical syndromes, and risk assessment procedures for developmental neurotoxicants. The editors and chapter authors are internationally recognized experts whose collaboration heralds a remarkable advance in the field, bridging developmental neuroscience with the principles of neurotoxicology. The book features eight new chapters with newly recruited authors, making it an essential text for students and professionals in toxicology, neurotoxicology, developmental biology, pharmacology, and neuroscience. Presents a comprehensive, up-to-date resource on developmental neurotoxicology with updated chapters from the first edition Contains new chapters that focus on subjects recent to the field Includes well-illustrated material, with diagrams, charts, and tables Contains compelling case studies and chapters written by world experts

Gut Microbiome and Behavior

Gut Microbiome and Behavior Book
Author : Anonim
Publisher : Academic Press
Release : 2016-10-25
ISBN : 0128039760
Language : En, Es, Fr & De

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Book Description :

Gut Microbiome and Behavior, the latest volume in the International Review of Neurobiology series, provides a comprehensive overview of the gut microbiome on the brain and behavior, fully encapsulating the latest research in the field and defining the scope of this influence to outline potential mechanisms and possible implications. Contains the expertise of contributors in the field who discuss the gut microbiome and its effect on the brain and behavior Defines the scope of the influence of the gut microbiome and the potential mechanisms and implications Charts the way forward in this frontier area of research

The Gut Microbiome An Issue of Gastroenterology Clinics of North America E Book

The Gut Microbiome  An Issue of Gastroenterology Clinics of North America  E Book Book
Author : Eamonn M.M. Quigley
Publisher : Elsevier Health Sciences
Release : 2017-02-09
ISBN : 0323509975
Language : En, Es, Fr & De

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Book Description :

Dr. Quigley has created a must-have reference on the gut microbiome for the practicing gastroenterologist. A leader in the field of human physiology and digestive disorders, he has laid out the basics on this increasingly important topic, devoting articles to the organization and biology of the human gut microbiome as well as its diagnostic potential. Top international authors have presented articles that discuss the intersection of the gut microbiome and diet and the gut-brain axis. Clinical implications of the gut microbiome are discussed with disease states like IBD, GI cancer, and liver diseases. Finally, the issue ends with the cutting-edge clinical innovation of fecal microbial transplantation. This issue bridges the gap between science and clinical practice and should be an important reference to practicing gastroenterologists.

Probiotics in Mental Health

Probiotics in Mental Health Book
Author : Colin R. Martin,Derek Larkin
Publisher : CRC Press
Release : 2018-05-30
ISBN : 1466573570
Language : En, Es, Fr & De

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Book Description :

The concept that the gut and brain are intricately linked is widely accepted not just within the lay community but increasingly within scientific and therapeutic circles as well. Terms such as "heartache" and "gut wrenching" are more than mere metaphor, they represent key fundamental aspects of human experience which all individuals will invariably endure from time to time. The relationship between the gut and brain is complex but fundamental to health and wellbeing. Increasing and compelling evidence supports the existence of a relationship between the health and status of the gut and the manifestation of significant psychopathology. Uniquely within the field of mental health and psychiatry, the role of gut flora and probiotics in both the understanding and treatment of mental illness represents an emerging science whether the potential for therapeutic intervention, through the use of probiotics, offers an opportunity to determine efficacy within a coherent evidence-based model of both action and pathology or, moreover, offers interventions that are comparatively benign compared to the side-effect profile associated with most drugs used to treat mental illness. Probiotics in Mental Health examines the role of probiotics in a range of clinical presentations associated with significant psychopathology and facilitates a reconsideration of how mental illness may be conceptualised within a coherent gut-brain model of health and wellbeing. Under the rubric of enhancing wellbeing rather than dwelling on illness and disease, this exciting new volume not only comprises the latest evidence in the field but also advocates an approach characterised by the understanding of mental disorder within an evidence-based model and the pursuit of mental health and wellbeing through the most benign of interventions.

Clinical Physiology in Anesthetic Practice

Clinical Physiology in Anesthetic Practice Book
Author : Michael G. Levitzky
Publisher : McGraw Hill Professional
Release : 2020-12-04
ISBN : 1259641961
Language : En, Es, Fr & De

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Book Description :

A clinically relevant, reader -friendly text covering everything the anesthesia provider must know about physiology This well-illustrated new resource is the most concise and high-yield presentation of physiology topics available to the anesthesia provider. The authors (who are both educators and clinicians) deliver a complete overview of physiology, but, since this book is written for the anesthesia provider, the bulk of the text is dedicated to cardiovascular and respiratory physiology. Clinical Physiology in Anesthetic Practice distinguishes itself from general medical physiology books by the inclusion of case studies and clinical correlation boxed inserts that emphasize key fact that relate to real-world practice. •Numerous case studies demonstrate the clinical relevance of basic science•The author are experienced educators and clinicians, and know how to present difficult concepts in the most interesting and reader-friendly manner possible•Key Points summarize must-know information, providing an excellent framework for board review

Diet Microbe Interactions in the Gut

Diet Microbe Interactions in the Gut Book
Author : Kieran Tuohy,Daniele Del Rio
Publisher : Academic Press
Release : 2014-08-04
ISBN : 0124079415
Language : En, Es, Fr & De

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Book Description :

Drawing on expert opinions from the fields of nutrition, gut microbiology, mammalian physiology, and immunology, Diet-Microbe Interactions for Human Health investigates the evidence for a unified disease mechanism working through the gut and its resident microbiota, and linking many inflammation-related chronic diet associated diseases. State of the art post-genomic studies can highlight the important role played by our resident intestinal microbiota in determining human health and disease. Many chronic human diseases associated with modern lifestyles and diets — including those localized to the intestinal tract like inflammatory bowel disease and celiac disease, and more pervasive systemic conditions such as obesity, diabetes and cardiovascular disease — are characterized by aberrant profiles of gut bacteria or their metabolites. Many of these diseases have an inflammatory basis, often presenting with a chronic low-grade systemic inflammation, hinting at persistent and inappropriate activation of inflammatory pathways. Through the presentation and analysis of recent nutrition studies, this book discusses the possible mechanisms underpinning the disease processes associated with these pathologies, with high fat diets appearing to predispose to disease, and biologically active plant components, mainly fiber and polyphenols, appearing to reduce the risk of chronic disease development. One comprehensive, translational source for all aspects of nutrition and diet's effect on gastrointestinal health and disease Experts in nutrition, diet, microbiology and immunology take readers from the bench research (cellular and biochemical mechanisms of vitamins and nutrients) to new preventive and therapeutic approaches Clear presentations by leading researchers of the cellular mechanisms underlying diet, immune response, and gastrointestinal disease help practicing nutritionists and clinicians (gastroenterologists, endocrinologists) map out new areas for clinical research and structuring clinical recommendations

Recent Discoveries in Evolutionary and Genomic Microbiology

Recent Discoveries in Evolutionary and Genomic Microbiology Book
Author : Anton G. Kutikhin,Arseniy E. Yuzhalin
Publisher : Frontiers Media SA
Release : 2015-08-04
ISBN : 2889196178
Language : En, Es, Fr & De

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Book Description :

This collection represents certain discoveries that were made in evolutionary and genomic microbiology during the recent ten years. We attempted to shed light on topical issues of microbial evolution and microbiome biology. In our eyes, these articles are of an excellent quality and may be helpful both for casual readers and for specialists in the field.

Harrison s Principles of Internal Medicine 20 E Vol 1 Vol 2 ebook

Harrison s Principles of Internal Medicine 20 E  Vol 1   Vol 2   ebook  Book
Author : Dennis L. Kasper,Anthony S. Fauci,Stephen L. Hauser,Dan L. Longo,J. Larry Jameson,Joseph Loscalzo
Publisher : McGraw Hill Professional
Release : 2018-02-06
ISBN : 1259644049
Language : En, Es, Fr & De

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Book Description :

MASTER MODERN MEDICINE! Introducing the Landmark Twentieth Edition of the Global Icon of Internal Medicine The definitive guide to internal medicine is more essential than ever with the latest in disease mechanisms, updated clinical trial results and recommended guidelines, state-of-the art radiographic images, therapeutic approaches and specific treatments, hundreds of demonstrative full-color drawings, and practical clinical decision trees and algorithms Recognized by healthcare professionals worldwide as the leading authority on applied pathophysiology and clinical medicine, Harrison’s Principles of Internal Medicine gives you the informational foundation you need to provide the best patient care possible. Essential for practice and education, the landmark 20th Edition features: Thoroughly revised content—covering the many new breakthroughs and advances in clinical medicine that have occurred since the last edition of Harrison’s. Chapters on acute and chronic hepatitis, management of diabetes, immune-based therapies in cancer, multiple sclerosis, cardiovascular disease, HIV, and many more, deliver the very latest information on disease mechanisms, diagnostic options, and the specific treatment guidance you need to provide optimal patient care. State-of-the-art coverage of disease mechanisms: Harrison’s focuses on pathophysiology with rigor, and with the goal of linking disease mechanisms to treatments. Improved understanding of how diseases develop and progress not only promotes better decision-making and higher value care, but also makes for fascinating reading and improved retention. Harrison’s summarizes important new basic science developments, such as the role of mitochondria in programmed and necrotic cell death, the immune system’s role in cancer development and treatment, the impact of telomere shortening in the aging and disease processes, and the role of the microbiome in health and disease. Understanding the role of inflammation in cardiovascular disease, the precise mechanisms of immune deficiency in HIV/AIDS, prions and misfolded proteins in neurodegenerative diseases, and obesity as a predisposition to diabetes are just a few examples of how this edition provides essential pathophysiology information for health professionals. All-new sections covering a wide range of new and emerging areas of vital interest to all healthcare professionals. New sections include: Sex and Gender-based Issues in Medicine; Obesity, Diabetes Mellitus, and Metabolic Syndrome; and Consultative Medicine— Plus, a new Part covering cutting-edge topics in research and clinical medicine includes great new chapters on the role of Epigenetics in Health and Disease, Behavioral Strategies to Improve Health, Genomics and Infectious Diseases, Emerging Neuro-Therapeutic Technologies, and Telomere Function in Health and Disease, and Network System Medicine. Important and timely new chapters—such as Promoting Good Health, LGBT Health, Systems of Healthcare, Approach to Medical Consultation, Pharmacogenomics, Antimicrobial Resistance, Worldwide Changes in Patterns of Infectious Diseases, Neuromyelitis Optica, and more—offer the very latest, definitive perspectives on must-know topics in medical education and practice. Updated clinical guidelines, expert opinions, and treatment approaches from world-renowned editors and authors contribute to the accuracy and immediacy of the text material and present a clear blueprint for optimizing patient outcomes. End-of-chapter suggested readings reinforce the text material and provide a robust platform for further study and research.

Follow Your Gut

Follow Your Gut Book
Author : Rob Knight
Publisher : Simon and Schuster
Release : 2015-04-07
ISBN : 1476784744
Language : En, Es, Fr & De

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Book Description :

Details the tiny word of microbes living inside our bodies and how they affect our health, asserting that proper regulation of these microbes through diet choices, probiotics and more can help battle allergies, asthma, obesity, acne, stomachaches and more.

Principles of Rehabilitation Medicine

Principles of Rehabilitation Medicine Book
Author : Raj Mitra
Publisher : McGraw Hill Professional
Release : 2018-10-12
ISBN : 0071793348
Language : En, Es, Fr & De

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Book Description :

A high-yield board review and quick reference for Rehabilitation Medicine Rehabilitation Medicine Rapid Review is written primarily for Physical Medicine and Rehabilitation residents preparing for their board exams, and is also an excellent reference for practicing physicians who need a primer on this rapidly growing specialty. With content organized around the American board of Physical Medicine and Rehabilitation core curriculum, this powerful review is enhanced by more than 500 review questions and answers, and concise, bulleted, high-yield text. Readers will find quick answers to common and infrequent issues encountered in rehabilitation medicine

Clinical Cases for General Practice Exams Fourth Edition

Clinical Cases for General Practice Exams  Fourth Edition Book
Author : Susan Wearne
Publisher : McGraw-Hill Education Australia
Release : 2019-08-14
ISBN : 1743767463
Language : En, Es, Fr & De

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Book Description :

Clinical Cases for General Practice Exams 4e is the ideal reference for the Australian general practice clinical examination. This fourth edition continues with the role-play style of the highly regarded previous editions. Inspired by real-life patient presentations, the cases allow learners to practise their clinical examination skills. Each case includes instructions for the exam candidate, role-playing patient and case facilitator. The text is perfect for medical students and doctors training to be general practitioners. Features • All cases have been reviewed and updated. • Problem-based learning scenarios encourage critical thinking, communication and compassionate care in consultation, treatment and management. • Case Commentaries and Common Pitfalls reinforce key points and important issues raised by cases. What’s new? • New cases on refugee health, family violence and Aboriginal and Torres Strait Islander health.

Psychosomatic Medicine

Psychosomatic Medicine Book
Author : Chiharu Kubo,Tomifusa Kuboki
Publisher : Elsevier Science Health Science Division
Release : 2006
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

These proceedings are based on the papers given the 18th World Congress on Psychosomatic Medicine. They cover current areas of particular interest in psychosomatic medicine, such as: mechanism of interactions of mind and body on psychosomatic diseases, psychoneuroimmunology, stress science and its evaluation, basic study and treatment of eating disorders, panic disorders, psycho-oncology, sexual dysfunction, cardiovascular disorders, gastrointestinal disorders, respiratory disorders, chronic pain disorders, chronic fatigue syndrome, complementary and alternative medicine, doctor-patient relationship, and all of other clinical problems.

Cell Tissue Injury and Cytoprotection Organoprotection in the Gastrointestinal Tract

Cell Tissue Injury and Cytoprotection Organoprotection in the Gastrointestinal Tract Book
Author : L.P. Filaretova,K. Takeuchi
Publisher : Karger Medical and Scientific Publishers
Release : 2012-06-22
ISBN : 3318021849
Language : En, Es, Fr & De

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Book Description :

In recent years, there have been significant advances both in understanding the mechanisms involved in gastrointestinal mucosal injury and protection, as well as in the development of successful strategies for prevention and treatment of gastrointestinal injury. Nevertheless, many people worldwide still suffer from gastrointestinal damage.This book contains contributions by an international panel of researchers in the form of up-to-date reviews on the mechanisms of gastrointestinal injury and protection. These are complemented by papers discussing how these new findings about cell/tissue injury and cytoprotection/organoprotection can be applied to the prevention and treatment of tissue damage in the gastrointestinal tract. Moreover, the publication includes a special chapter on Andre Robert, who has discovered the phenomenon of gastric cytoprotection.This publication will be of great interest for both basic and clinical researchers in gastroenterology and pharmacology, reviewing the advances made so far and pointing towards future developments.

Digestive Wellness Strengthen the Immune System and Prevent Disease Through Healthy Digestion Fifth Edition

Digestive Wellness  Strengthen the Immune System and Prevent Disease Through Healthy Digestion  Fifth Edition Book
Author : Elizabeth Lipski
Publisher : McGraw Hill Professional
Release : 2019-11-22
ISBN : 1260019403
Language : En, Es, Fr & De

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Book Description :

Optimize your overall health through digestive wellness! Fewer antacids and less bloating aren’t the only benefits of good digestion. When your digestive system is healthy and balanced, you sleep better, have more energy, think more clearly, experience less pain, and combat disease more effectively. Digestive Health shows how everything from migraines to skin disease to arthritis are connected to your digestive system. And now, this go-to guide has been updated with critical new research and developments, including late-breaking information on: • Probiotics and Prebiotics • Celiac Disease • The Gut-Brain Connection • Carbohydrates • Leaky Gut Syndrome • Auto-Immune Conditions • Kidney and Bone Health • Cancer Prevention • Alzheimer’s Disease You’ll find practical solutions to numerous conditions and disorders, along with expert guidance on the newest advances in testing and diagnosis, nutrition, and natural therapies. A perfect balance of science and practical advice, Digestive Health explains how your digestive system works and what to do when it doesn’t function properly. It provides everything you need to take control of your overall health through close, careful attention to your digestive system.

Peripheral and Central Mechanisms in Irritable Bowel Syndrome

Peripheral and Central Mechanisms in Irritable Bowel Syndrome Book
Author : Olga Bednarska
Publisher : Linköping University Electronic Press
Release : 2019-05-07
ISBN : 9176850935
Language : En, Es, Fr & De

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Book Description :

Irritable bowel syndrome (IBS) is a chronic visceral pain disorder with female predominance, characterized by recurrent abdominal pain and disturbed bowel habits in the absence of an identifiable organic cause. This prevalent and debilitating disease, which accounts for a substantial economic and individual burden, lacks exact diagnostic tools and effective treatment, since its pathophysiology remains uncertain. The bidirectional and multilayered brain-gut axis is a well-established disease model, however, the interactions between central and peripheral mechanisms along the brain-gut axis remain incompletely understood. One of the welldescribed triggering factors, yet accounting for only a fraction of IBS prevalence, is bacterial gastroenteritis that affects mucosal barrier function. Altered gut microbiota composition as well as disturbed intestinal mucosal barrier function and its neuroimmune regulation have been reported in IBS, however, the impact of live bacteria, neither commensal nor pathogenic, on intestinal barrier has not been studied yet. Furthermore, abnormal central processing of visceral sensations and psychological factors such as maladaptive coping have previously been suggested as centrally-mediated pathophysiological mechanisms of importance in IBS. Brain imaging studies have demonstrated an imbalance in descending pain modulatory networks and alterations in brain regions associated with interoceptive awareness and pain processing and modulation, particularly in anterior insula (aINS), although biochemical changes putatively underlying these central alterations remain poorly understood. Most importantly, however, possible associations between these documented changes on central and peripheral levels, which may as complex interactions contribute to disease onset and chronification of symptoms, are widely unknown. This thesis aimed to investigate the peripheral and central mechanisms in women with IBS compared to female healthy controls (HC) and to explore possible mutual associations between these mechanisms. In Paper I, we studied paracellular permeability and passage of live bacteria, both commensal and pathogenic through colonic biopsies mounted in Ussing chambers. We explored the regulation of the mucosal barrier function by mast cells and the neuropeptide vasoactive intestinal polypeptide (VIP) as well as a correlation between mucosal permeability and gastrointestinal and psychological symptoms. We observed increased paracellular permeability and the passage of commensal and pathogenic live bacteria in patients with IBS compared with HC, which was diminished by blocking the VIP receptors as well as after stabilizing mast cells in both groups. Moreover, higher paracellular permeability was associated with less somatic and psychological symptoms in patients. In Paper II, we aimed to determine the association between colonic mucosa paracellular permeability and structural and resting state functional brain connectivity. We demonstrated different patterns of associations between mucosa permeability and functional and structural brain connectivity in IBS patients compared to HC. Specifically, lower paracellular permeability in IBS, similar to the levels detected in HC, was associated with more severe IBS symptoms and increased functional and structural connectivity between intrinsic brain resting state network and descending pain modulation brain regions. Our findings further suggested that this association between mucosa permeability and functional brain connectivity was mainly mediated by coping strategies. In Paper III, we investigated putative alterations in excitatory and inhibitory neurotransmission of aINS, as the brain’s key node of the salience network crucially involved in cognitive control, in IBS patients relative to HC and addressed possible connections with both symptoms and psychological factors. We found decreased concentrations of the excitatory neurotransmitter Glx in bilateral aINS in IBS patients compared to HC, while inhibitory neurotransmitter GABA+ levels were comparable. Further, we demonstrated hemisphere-specific associations between abdominal pain, coping and aINS excitatory neurotransmitter concentration. In conclusion, this thesis broadens the knowledge on peripheral and central mechanisms in IBS and presents novel findings that bring together the ends of brain-gut axis. Our results depict association between mucosal permeability, IBS symptoms and functional and structural connectivity engaging brain regions involved in emotion and pain modulation as well as underlying neurotransmitter alterations.

Immunopsychiatry

Immunopsychiatry Book
Author : Antonio L. Teixeira,Moises E. Bauer
Publisher : Oxford University Press, USA
Release : 2019-01-18
ISBN : 0190884460
Language : En, Es, Fr & De

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Book Description :

In recent years, a dedicated effort has been made to understand the immune dysfunction that is associated with major psychiatric disorders. The expanding knowledge of the immune system as a major homeostatic system has been very helpful in indicating new potential biomarkers and therapeutic targets to reduce the burden of psychiatric disorders. Indeed, immune cells, their secreted molecules, and cell signalling events are highly promising. Yet, the literature on immunology of psychiatric disorders is still dispersed, and only a few attempts have been made to consolidate the current knowledge in this expanding area. This book assembles and presents the available data on the immune/inflammatory dysfunction in psychiatric disorders, indicating the potential of immune mechanisms as either biomarkers or therapeutic targets, as well as discussing the challenges ahead of incorporating this knowledge into clinical practice. An international team of senior experts in the field review all psychiatric disorders in order to provide an integrated, in-depth understanding of the role of immune changes in psychiatric diseases for mental health clinicians as well as for researchers in immunology, psychiatry, neurology, and pharmacology.

Harrison s Principles of Internal Medicine 19 E Vol 1 Vol 2 ebook

Harrison s Principles of Internal Medicine 19 E  Vol 1   Vol 2   ebook  Book
Author : Dennis L. Kasper,Anthony S. Fauci,Stephen L. Hauser,Dan L. Longo,J. Larry Jameson,Joseph Loscalzo
Publisher : McGraw Hill Professional
Release : 2015-04-17
ISBN : 0071802169
Language : En, Es, Fr & De

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Book Description :

The landmark guide to internal medicine— updated and streamlined for today’s students and clinicians The only place you can get ALL the great content found in the two print volumes AND the acclaimed DVD in one convenient resource! Through six decades, no resource has matched the authority, esteemed scholarship, and scientific rigor of Harrison’s Principles of Internal Medicine. Capturing the countless advances and developments across the full span of medicine, the new 19th edition of Harrison’s provides a complete update of essential content related to disease pathogenesis, clinical trials, current diagnostic methods and imaging approaches, evidence-based practice guidelines, and established and newly approved treatment methods. Here are just a few of the outstanding features of the new Nineteenth Edition: Content is practically organized around two basic themes: education and clinical practice The teaching and learning sections cover foundational principles, cardinal manifestations of disease and approach to differential diagnosis; the content devoted to clinical practice focuses on disease pathogenesis and treatment NEW chapters on important topics such as Men’s Health, The Impact of Global Warming on Infectious Diseases, Fatigue, and many more Critical updates in management and therapeutics in Hepatitis, Coronary Artery Disease, Ebola Virus Disease, Multiple Sclerosis, Diabetes, Hypertension, Deep Vein Thrombosis and Pulmonary Embolism, Acute and Chronic Kidney Disease, Inflammatory Bowel Disease, Lipoprotein Disorders, HIV and AIDS, and more. Increased number of the popular Harrison’s clinical algorithms; clinically relevant radiographic examples spanning hundreds of diseases; clinical-pathological images in full color; crystal clear, full color drawings and illustrations and helpful tables and summary lists that make clinical application of the content faster than ever Outstanding multi-media resources including practical videos demonstrating essential bedside procedures, physical examination techniques, endoscopic findings, cardiovascular findings, are available for easy download Supporting the renowned coverage are supplemental resources that reflect and assist modern medical practice: more than 1,000 full-color photographs to aid visual recognition skills, hundreds of state-of-the-art radiographs, from plain film to 3D CT to PET Scans; beautiful illustrations that bring applied anatomy and processes to life; the renowned Harrison’s patient-care algorithms, essential summary tables, and practical demonstrative videos. In addition, several digital atlases highlight noninvasive imaging, percutaneous revascularization, gastrointestinal endoscopy, diagnosis and management of vasculitis, and numerous other issues commonly encountered in clinical practice. Acclaim for Harrison’s: “Covering nearly every possible topic in the field of medicine, the book begins with a phenomenal overview of clinical medicine, discussing important topics such as global medicine, decision-making in clinical practice, the concepts of disease screening and prevention, as well as the importance of medical disorders in specific groups (e.g. women, surgical patients, end of life). The extensive chapters that follow focus on a symptom-based presentation of disease and then illness organized by organ system. Numerous tables, graphs, and figures add further clarity to the text." ...Written by experts in the field, this book is updated with the latest advances in pathophysiology and treatment. It is organized in a way that makes reading from beginning to end a logical journey, yet each chapter can stand alone as a quick reference on a particular topic. “ Doody’s Review Service reviewing the previous edition of Harrison’s