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Microbial Metabolic Pathways And Disease

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Microbial Metabolism and Disease

Microbial Metabolism and Disease Book
Author : Elena L. Paley
Publisher : Academic Press
Release : 2021-03-13
ISBN : 0323884466
Language : En, Es, Fr & De

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Book Description :

Microbiome Metabolic Pathways and Disease provides insight into the interaction of microbial metabolic pathways in the human body and the impact these can have on a variety of diseases. By analyzing these pathways the book seeks to investigate how these metabolic processes can be targeted and manipulated in order to treat various disorders and diseases. Topics covered in the book include microbial shikimate pathways, protein biosynthesis, tryptophan metabolites, microbiome metabolic engineering, fecal microbiota transplantation, and virulence factors. Additionally, a variety of conditions are covered, such as disorders associated with metabolic syndromes, serotonin syndromes, Alzheimer’s disease, and Covid-19, providing a detailed overview of how metabolic pathways of microbiome can impact health and disease in the human body. Explores microbial metabolic pathways in the human body and implications for disease Investigates specific steps involved in metabolic reactions in the human microbiome, including shikimate pathways and tryptophan pathways Considers a variety of diseases and disorders, such as Alzheimer’s disease, metabolic syndromes, Crohn’s disease and Covid-19 Includes analysis of various amino acids and enzymes in microbial and human cells and how these can impact health

Engineering Rumen Metabolic Pathways Where We Are and Where Are We Heading

Engineering Rumen Metabolic Pathways  Where We Are  and Where Are We Heading Book
Author : Emilio M. Ungerfeld,C. James Newbold
Publisher : Frontiers Media SA
Release : 2018-03-13
ISBN : 2889454266
Language : En, Es, Fr & De

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Book Description :

Ruminants were domesticated in the Middle East about 10,000 years ago and have since become an inseparable part of human diet, society, and culture. Ruminants can transform inedible plant fiber and non-protein nitrogen into meat, milk, wool and traction, thus allowing human utilization of non-tillable land and industrial by-products. The nutritional flexibility of ruminants is conferred by the rumen´s complex microbial community. Driven by rising income and population growth in emergent economies, the global demand for livestock products, including milk and meat from ruminants, has been increasingly growing, and is predicted to continue growing in the next few decades. The increase in production necessary to satisfy this rising demand is putting much pressure on already dwindling natural resources. There are also concerns about the emissions of methane and nitrous oxide, potent greenhouse gases associated to ruminant production. The need to make ruminant production more efficient in the use of natural resources poses a big challenge to ruminant science, and within it, rumen microbiology. Recent years have seen important advances in basic and applied rumen microbiology and biochemistry. The knowledge generated has significant implications for the efficiency and sustainability of ruminant production and the quality of ruminant products for human health. The present compilation is an update of recent advances in rumen microbiology and ruminant digestion and fermentation, including original research, reviews, and hypothesis and theory articles. We hope that the experimental results, discussion, models and ideas presented herein are useful to foster future research contributing to sustainable ruminant production.

Sequence Evolution Function

Sequence     Evolution     Function Book
Author : Eugene V. Koonin,Michael Galperin
Publisher : Springer Science & Business Media
Release : 2013-06-29
ISBN : 1475737831
Language : En, Es, Fr & De

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Book Description :

Sequence - Evolution - Function is an introduction to the computational approaches that play a critical role in the emerging new branch of biology known as functional genomics. The book provides the reader with an understanding of the principles and approaches of functional genomics and of the potential and limitations of computational and experimental approaches to genome analysis. Sequence - Evolution - Function should help bridge the "digital divide" between biologists and computer scientists, allowing biologists to better grasp the peculiarities of the emerging field of Genome Biology and to learn how to benefit from the enormous amount of sequence data available in the public databases. The book is non-technical with respect to the computer methods for genome analysis and discusses these methods from the user's viewpoint, without addressing mathematical and algorithmic details. Prior practical familiarity with the basic methods for sequence analysis is a major advantage, but a reader without such experience will be able to use the book as an introduction to these methods. This book is perfect for introductory level courses in computational methods for comparative and functional genomics.

The Science and Applications of Synthetic and Systems Biology

The Science and Applications of Synthetic and Systems Biology Book
Author : Institute of Medicine,Board on Global Health,Forum on Microbial Threats
Publisher : National Academies Press
Release : 2011-12-30
ISBN : 0309219396
Language : En, Es, Fr & De

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Book Description :

Many potential applications of synthetic and systems biology are relevant to the challenges associated with the detection, surveillance, and responses to emerging and re-emerging infectious diseases. On March 14 and 15, 2011, the Institute of Medicine's (IOM's) Forum on Microbial Threats convened a public workshop in Washington, DC, to explore the current state of the science of synthetic biology, including its dependency on systems biology; discussed the different approaches that scientists are taking to engineer, or reengineer, biological systems; and discussed how the tools and approaches of synthetic and systems biology were being applied to mitigate the risks associated with emerging infectious diseases. The Science and Applications of Synthetic and Systems Biology is organized into sections as a topic-by-topic distillation of the presentations and discussions that took place at the workshop. Its purpose is to present information from relevant experience, to delineate a range of pivotal issues and their respective challenges, and to offer differing perspectives on the topic as discussed and described by the workshop participants. This report also includes a collection of individually authored papers and commentary.

The Human Microbiome Diet and Health

The Human Microbiome  Diet  and Health Book
Author : Food Forum,Food and Nutrition Board,Institute of Medicine
Publisher : National Academies Press
Release : 2013-02-27
ISBN : 030926586X
Language : En, Es, Fr & De

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Book Description :

The Food Forum convened a public workshop on February 22-23, 2012, to explore current and emerging knowledge of the human microbiome, its role in human health, its interaction with the diet, and the translation of new research findings into tools and products that improve the nutritional quality of the food supply. The Human Microbiome, Diet, and Health: Workshop Summary summarizes the presentations and discussions that took place during the workshop. Over the two day workshop, several themes covered included: The microbiome is integral to human physiology, health, and disease. The microbiome is arguably the most intimate connection that humans have with their external environment, mostly through diet. Given the emerging nature of research on the microbiome, some important methodology issues might still have to be resolved with respect to undersampling and a lack of causal and mechanistic studies. Dietary interventions intended to have an impact on host biology via their impact on the microbiome are being developed, and the market for these products is seeing tremendous success. However, the current regulatory framework poses challenges to industry interest and investment.

Metabolic Interaction in Infection

Metabolic Interaction in Infection Book
Author : Ricardo Silvestre,Egídio Torrado
Publisher : Springer
Release : 2018-04-06
ISBN : 3319749323
Language : En, Es, Fr & De

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Book Description :

This book focuses on host–pathogen interactions at the metabolic level. It explores the metabolic requirements of the infectious agents, the microbial metabolic pathways that are dedicated to circumvent host immune mechanisms as well as the molecular mechanisms by which pathogens hijack host cell metabolism for their own benefit. Finally, it provides insights on the possible clinical and immunotherapeutic applications, as well as on the available experimental and analytical methods. The contributions break new ground in understanding the metabolic crosstalk between host and pathogen.

Bacterial Physiology and Metabolism

Bacterial Physiology and Metabolism Book
Author : Byung Hong Kim,Geoffrey Michael Gadd
Publisher : Cambridge University Press
Release : 2008-02-21
ISBN : 9781139467629
Language : En, Es, Fr & De

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Book Description :

Recent determination of genome sequences for a wide range of bacteria has made in-depth knowledge of prokaryotic metabolic function essential in order to give biochemical, physiological, and ecological meaning to the genomic information. Clearly describing the important metabolic processes that occur in prokaryotes under different conditions and in different environments, this advanced text provides an overview of the key cellular processes that determine bacterial roles in the environment, biotechnology, and human health. Prokaryotic structure is described as well as the means by which nutrients are transported into cells across membranes. Glucose metabolism through glycolysis and the TCA cycle are discussed, as well as other trophic variations found in prokaryotes, including the use of organic compounds, anaerobic fermentation, anaerobic respiratory processes, and photosynthesis. The regulation of metabolism through control of gene expression and control of the activity of enzymes is also covered, as well as survival mechanisms used under starvation conditions.

Molecular Biology of the Cell

Molecular Biology of the Cell Book
Author : Bruce Alberts
Publisher : Unknown
Release : 2004
ISBN : 9780815332183
Language : En, Es, Fr & De

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Book Description :

Download Molecular Biology of the Cell book written by Bruce Alberts, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Reprogramming Microbial Metabolic Pathways

Reprogramming Microbial Metabolic Pathways Book
Author : Xiaoyuan Wang,Jian Chen,Peter Quinn
Publisher : Springer Science & Business Media
Release : 2012-10-20
ISBN : 9400750544
Language : En, Es, Fr & De

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Book Description :

Metabolic engineering has been developed over the past 20 years to become an important tool for rational engineering of microorganisms. This book has a particular interest in the methods and applications of metabolic engineering to improve the production and yield of a variety of metabolites in microorganisms. The overall goal is to achieve a better understanding of metabolism in different microorganisms, and provide a rational basis to reprogram microorganisms for improved biochemical production. This book brings together contributions from leading researchers at the cutting edge of these topics. The subject matter is divided into two sections. The first section deals with novel and emerging methods for redesigning microorganisms exploiting systems biology and gene regulation. The second discusses practical aspects of metabolic engineering for over production of a variety of valuable chemicals and materials by fermentation.

Mapping Metabolic Pathways for Mucosal Health at the Host microbe Interface

Mapping Metabolic Pathways for Mucosal Health at the Host microbe Interface Book
Author : Katti R. Crakes
Publisher : Unknown
Release : 2020
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Background: Human body surfaces are lined by mucosal membranes composed of epithelial cells which serve as the primary barrier for protection against pathogens. These mucous membranes function in a shared environment with resident microbes, creating a complex ecosystem with communal sources of nutrients for the host as well as its microbes. Encounters with viral, fungal, and bacterial pathogens can directly or indirectly damage epithelial cells, disrupting tight junctions that keep mucosal barriers intact. Disruption of epithelial barriers lead to downstream inflammation, translocation of microbial products into the bloodstream, and exacerbation of disease. For example, Human immunodeficiency virus-1 (HIV) proteins can target zonula occludens for viral entry and dissemination, Clostridium perfringens utilizes claudin proteins as receptors for entry, and candidalysin toxin from Candida albicans targets junctional complexes for translocation, all of which induce permeability in epithelial barriers. Furthermore, autoimmune diseases such as inflammatory bowel disease and diabetes exhibit similar pathologies in intestinal barrier disruption and microbial dysbiosis. While these barrier defects have been observed across a broad range of diseases, there is a lack of understanding in how tight junctions are regulated by epithelial cells and which therapeutic targets will be effective. My dissertation takes two approaches to address this issue: 1) mucosal repair in chronic inflammation and 2) mucosal protection against pathogens. I hypothesized that strategies targeting entry of pathogens and cellular metabolism at mucosal sites will be fundamental for effective prevention and treatment of chronic diseases. This dissertation presents three studies that advance our knowledge about mucosal repair/protection by leveraging host-microbial metabolic pathways and mucoadhesive drug delivery systems. 1: Repair of gut epithelial barriers during SIV-induced chronic gut inflammation through the mitochondria-microbiota crosstalk. Chronic gut inflammatory diseases are associated with disruption of intestinal epithelial barriers and impaired mucosal immunity. HIV causes depletion of mucosal CD4+ T cells early in infection and disruption of gut epithelium, resulting in chronic inflammation and immunodeficiency. Although antiretroviral therapy is effective in suppressing viral replication, it is incapable of restoring the "leaky gut," which poses an impediment for HIV cure efforts. Using the intestinal loop model in SIV-infected rhesus macaques, we found rapid repair of gut epithelial barriers within five hours of administering Lactobacillus plantarum into virally inflamed gut. The rapid recovery was driven by peroxisome proliferator-activated receptor (PPAR[alpha]) activation and occurred independent of mucosal CD4+ T cell recovery, highlighting a metabolic repair pathway in mitochondrial [beta]-oxidation that can be targeted for epithelial repair prior to complete immune recovery. These findings highlight the critical role of PPAR[alpha] at the intersection between microbial metabolism and epithelial repair in virally inflamed gut and as a potential mitochondrial target for restoring gut barriers in infectious or inflammatory diseases. Study 2: Renewal of gut epithelial barriers in metabolic disease through PPAR[alpha] signaling at the host-microbe interface in metabolic disease. Metabolic disease affects approximately one-third of the US adult population, and is defined by pathological conditions associated with obesity, insulin resistance, hypertension, and hyperlipidemia. Metabolic disease is concomitant to dysfunctions in the intestinal barrier and an increased risk for mucosal infection and systemic inflammation, all of which are poorly understood. Using a canine model of diabetes mellitus (DM), we translated our findings in Study 1 and tested the clinical translation of PPAR[alpha] activation on gut epithelial barriers using fenofibrate, a known PPAR[alpha] agonist. We found that a 3-week oral dosage of fenofibrate alleviates small intestinal barrier disruption and improves lipid metabolism in dogs with DM. Reduction of plasma triglycerides after 3 weeks correlated with lower immune activation and reduction of intraepithelial T lymphocytes in the duodenum. The gut microbial composition remained stable after fenofibrate administration, suggesting that repair of intestinal barriers can be achieved independent of surrounding microbiota. These findings indicate that lipid metabolism is essential to functionality of the gut epithelium, which can be rescued by PPAR[alpha] activation in DM. Study 3: Protection of genital mucosal surfaces against HIV and SHIV viruses using Silk fibroin mucoadhesive delivery platform. Efforts to end the AIDS epidemic using anti-retroviral therapy have been widely successful in reducing HIV-related deaths. However, challenges for the prevention of new HIV infections have not been fully resolved. Most new HIV infections occur through mucosal transmission, so it is imperative that HIV prevention platforms are effective at mucosal sites, can be produced inexpensively, and are accessible to vulnerable populations. In these cases, protection against HIV transmission must overcome individual-to-individual variation in the context of mucosal microbiota composition, host metabolic status, and immune response. In this study, we developed a silk fibroin (SF)-based drug delivery platform that encapsulates a potent HIV entry inhibitor Griffithsin (Grft) that can be readily administered into genital mucosal sites for HIV prevention. The SF formulation, capable of holding several anti-HIV proteins, is thermodynamically stable for over one year, can be released over the course of one month, and provides an innovative platform that is safe and effective against transmission of HIV. We demonstrate the safety and efficacy of SF-Grft in both vaginal and rectal compartments using a non-human primate model in vivo and human explant cultures ex vivo. Effective release and mucosal adherence of SF-Grft protected against HIV and SHIV challenge with negligible changes in local microbiota or inflammatory responses. These findings provide support for the development of SF as an effective HIV prevention modality at mucosal sites to help address the global disparity in HIV infection. Conclusion: These studies provide novel insights into new metabolic targets to repair inflamed gut mucosa and impart protection against pathogens at mucosal surfaces through innovative mucoadhesive technology. This dissertation deciphers the molecular, cellular, and microbial components involved in chronic gut inflammatory diseases, identifies molecular mechanisms of reversing mucosal damage, and defines the significance of addressing this complexity to bolster systemic and mucosal health.

Food Microbiology

Food Microbiology Book
Author : Osman Erkmen,T. Faruk Bozoglu
Publisher : John Wiley & Sons
Release : 2016-06-13
ISBN : 1119237769
Language : En, Es, Fr & De

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Book Description :

This book covers application of food microbiology principles into food preservation and processing. Main aspects of the food preservation techniques, alternative food preservation techniques, role of microorganisms in food processing and their positive and negative features are covered. Features subjects on mechanism of antimicrobial action of heat, thermal process, mechanisms for microbial control by low temperature, mechanism of food preservation, control of microorganisms and mycotoxin formation by reducing water activity, food preservation by additives and biocontrol, food preservation by modified atmosphere, alternative food processing techniques, and traditional fermented products processing. The book is designed for students in food engineering, health science, food science, agricultural engineering, food technology, nutrition and dietetic, biological sciences and biotechnology fields. It will also be valuable to researchers, teachers and practising food microbiologists as well as anyone interested in different branches of food.

Protein Biosynthesis Interference in Disease

Protein Biosynthesis Interference in Disease Book
Author : Elena L. Paley
Publisher : Academic Press
Release : 2020-10-08
ISBN : 0128234865
Language : En, Es, Fr & De

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Book Description :

Protein Biosynthesis Interference in Disease offers a thorough discussion and overview of protein biosynthesis interference, its mechanisms of action, and influence over disease processes. This book examines the role of protein biosynthesis interference in Alzheimer’s and other neurodegenerative conditions, cancer and inflammatory disorders, with specific attention paid to the biochemical dynamics of tryptamine, biogenic amines and aminoacyl-tRNA synthetases in these pathologies. Methods of regulating protein translation and interference mechanisms, including gene therapy, are presented, empowering biochemists, molecular biologists, disease researchers, and health professionals to understand the underlying factors of protein disease and improve patient outcomes. Enables biochemists, molecular biologists and disease researchers to advance disease prevention, laboratory testing, and treatment pathways for protein biosynthesis interference related disorders Examines the biochemical and molecular basis of protein biosynthesis interference in neurodegenerative disorders, cancer and inflammatory conditions, among other diseases Analyzes tryptamine, biogenic amines, and aminoacyl-tRNA synthetases dynamics in protein translation and possible treatment pathways regulating protein biosynthesis

What You Need to Know about Infectious Disease

What You Need to Know about Infectious Disease Book
Author : Madeline Drexler
Publisher : Unknown
Release : 2022-08-08
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download What You Need to Know about Infectious Disease book written by Madeline Drexler, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Antibody Techniques

Antibody Techniques Book
Author : Vedpal S. Malik,Erik P. Lillehoj
Publisher : Academic Press
Release : 2013-10-22
ISBN : 1483285138
Language : En, Es, Fr & De

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Book Description :

The applicability of immunotechniques to a wide variety of research problems in many areas of biology and chemistry has expanded dramatically over the last two decades ever since the introduction of monoclonal antibodies and sophisticated immunosorbent techniques. Exquisitely specific antibody molecules provide means of separation, quantitative and qualitative analysis, and localization useful to anyone doing biological or biochemical research. This practical guide to immunotechniques is especially designed to be easily understood by people with little practical experience using antibodies. It clearly presents detailed, easy-to-follow, step-by-step methods for the widely used techniques that exploit the unique properties of antibodies and will help researchers use antibodies to their maximum advantage. Detailed, easy-to-follow, step-by-step protocols Convenient, easy-to-use format Extensive practical information Essential background information Helpful hints

Applications of Herbal Medicine to Control Chronic Kidney Disease

Applications of Herbal Medicine to Control Chronic Kidney Disease Book
Author : Jianping Chen,Karl Tsim,Ying-Yong Zhao
Publisher : Frontiers Media SA
Release : 2021-10-21
ISBN : 2889715280
Language : En, Es, Fr & De

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Book Description :

Download Applications of Herbal Medicine to Control Chronic Kidney Disease book written by Jianping Chen,Karl Tsim,Ying-Yong Zhao, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The Metabolic Challenges of Immune Cells in Health and Disease

The Metabolic Challenges of Immune Cells in Health and Disease Book
Author : Claudio Mauro,Christian Frezza
Publisher : Unknown
Release : 2015-07-13
ISBN : 2889196224
Language : En, Es, Fr & De

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Book Description :

Obesity and its co-morbidities, including atherosclerosis, insulin resistance and diabetes, are a world-wide epidemic. Inflammatory immune responses in metabolic tissues have emerged as a universal feature of these metabolic disorders. While initial work highlighted the contribution of macrophages to tissue inflammation and insulin resistance, recent studies demonstrate that cells of the adaptive immune compartment, including T and B lymphocytes and dendritic cells also participate in obesity-induced pathogenesis of these conditions. However, the molecular and cellular pathways by which the innate and adaptive branches of immunity control tissue and systemic metabolism remain poorly understood. To engage in growth and activation, cells need to increase their biomass and replicate their genome. This process presents a substantial bioenergetic challenge: growing and activated cells must increase ATP production and acquire or synthesize raw materials, including lipids, proteins and nucleic acids. To do so, they actively reprogram their intracellular metabolism from catabolic mitochondrial oxidative phosphorylation to glycolysis and other anabolic pathways. This metabolic reprogramming is under the control of specific signal transduction pathways whose underlying molecular mechanisms and relevance to physiology and disease are subject of considerable current interest and under intense study. Recent reports have elucidated the physiological role of metabolic reprogramming in macrophage and T cell activation and differentiation, B- and dendritic cell biology, as well as in the crosstalk of immune cells with endothelial and stem cells. It is also becoming increasingly evident that alterations of metabolic pathways play a major role in the pathogenesis of chronic inflammatory disorders. Due to the scientific distance between immunologists and experts in metabolism (e.g., clinicians and biochemists), however, there has been limited cross-talk between these communities. This collection of articles aims at promoting such cross-talk and accelerating discoveries in the emerging field of immunometabolism.

Microbiology

Microbiology Book
Author : Nina Parker,OpenStax,Mark Schneegurt,AnhHue Thi Tu,Brian M. Forster,Philip Lister
Publisher : Unknown
Release : 2016-05-30
ISBN : 9781938168147
Language : En, Es, Fr & De

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Book Description :

"Microbiology covers the scope and sequence requirements for a single-semester microbiology course for non-majors. The book presents the core concepts of microbiology with a focus on applications for careers in allied health. The pedagogical features of the text make the material interesting and accessible while maintaining the career-application focus and scientific rigor inherent in the subject matter. Microbiology's art program enhances students' understanding of concepts through clear and effective illustrations, diagrams, and photographs. Microbiology is produced through a collaborative publishing agreement between OpenStax and the American Society for Microbiology Press. The book aligns with the curriculum guidelines of the American Society for Microbiology."--BC Campus website.

Shaping of Human Immune System and Metabolic Processes by Viruses and Microorganisms

Shaping of Human Immune System and Metabolic Processes by Viruses and Microorganisms Book
Author : Marina I. Arleevskaya,Rustam Aminov,Wesley H. Brooks,Gayane Manukyan,Yves Renaudineau
Publisher : Frontiers Media SA
Release : 2019-08-15
ISBN : 2889459411
Language : En, Es, Fr & De

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Book Description :

Recent advances in the understanding of microbiota in health and diseases are presented in this special issue of Frontiers in Immunology and Frontiers in Microbiology as well as their impact on the immune system that can lead to the development of pathologies. Potential perspectives and biomarkers are also addressed. We offer this Research Topic involving 64 articles and 501 authors to discuss recent advances regarding: 1. An overview of the human microbiota and its capacity to interact with the human immune system and metabolic processes, 2. New developments in understanding the immune system’s strategies to respond to infections and escape strategies used by pathogens to counteract such responses, 3. The link between the microbiota and pathology in terms of autoimmunity, allergy, cancers and other diseases.

Metabolic Pathway Engineering

Metabolic Pathway Engineering Book
Author : Jean F. Challacombe
Publisher : CRC Press
Release : 2021-07-15
ISBN : 1000260542
Language : En, Es, Fr & De

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Book Description :

Metabolic systems engineering combines the tools and approaches of systems biology, synthetic biology, and evolutionary engineering. This book reviews studies on metabolism, from the earliest work of Lavoisier and Buchner to current cutting-edge research in metabolic systems engineering. This technology has been used in bioengineering applications to create high-performing microbes and plants that produce important chemicals, pharmaceuticals, crops, and other natural products. Current applications include optimizing metabolic pathways to enhance degradation of biomass for biofuel production and accelerated processing of environmental waste products and contaminants. The book includes examples to illustrate the applications of this technology in the optimization of metabolic pathways to create robust industrial strains as well as in the engineering of biological processes involving health and diseases of humans, animals, and plants. Written by a seasoned computational biologist with many years of experience in genomics, bioinformatics, and systems biology, this book will appeal to anyone interested in metabolic systems analysis and metabolic pathway engineering.

Metabolism and Bacterial Pathogenesis

Metabolism and Bacterial Pathogenesis Book
Author : Tyrrell Conway,Paul S. Cohen
Publisher : John Wiley & Sons
Release : 2015-09-01
ISBN : 1683673344
Language : En, Es, Fr & De

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Book Description :

Groundbreaking thinking on how bacterial metabolism is foundational to pathogenesis For too long, bacterial metabolism and bacterial pathogenesis have been studied as separate entities. However, the scientific community is beginning to realize that not only are bacterial nutrient acquisition and utilization essential for pathogenesis, but that interfering with the pathogen-specific metabolic pathways used during infection can regulate virulence factor expression and might lead to effective breakthroughs in a variety of treatments. Editors Paul Cohen and Tyrrell Conway, who pioneered the use of metabolic mutants in competitive colonization assays, an approach now widely used to investigate the nutrition of pathogens in vivo, are uniquely qualified to advance our knowledge of this integrative field of research. They convened a group of contributors who are breaking new ground in understanding how bacterial metabolism is foundational to pathogenesis to share their expert perspectives and outlook for the future. Beginning with overviews, Metabolism and Bacterial Pathogenesis covers a wide range of diseases and both Gram-positive and -negative bacteria that serve as model systems for in vitro and in vivo investigations intracellular, respiratory, and enteric pathogens pathogen-specific nutrient acquisition in hosts mechanisms of host-driven metabolic adaptation by pathogens metabolic regulation of virulence gene expression Useful for specialists in bacterial pathogenesis and specialists in metabolism as well as molecular biologists, physicians, veterinarians, dentists, graduate and undergraduate students, and laboratory technicians, Metabolism and Bacterial Pathogenesis is also essential reading for scientists studying the microbiome.