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Micro Drops And Digital Microfluidics

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Micro Drops and Digital Microfluidics

Micro Drops and Digital Microfluidics Book
Author : Jean Berthier
Publisher : William Andrew
Release : 2012-12-31
ISBN : 1455728004
Language : En, Es, Fr & De

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Book Description :

In this 2nd edition of Micro-Drops and Digital Microfluidics, Jean Berthier explores the fundamentals and applications of digital microfluidics, enabling engineers and scientists to design this important enabling technology into devices and harness the considerable potential of digital microfluidics in testing and data collection. This book describes the most recent developments in digital microfluidics, with a specific focus on the computational, theoretical and experimental study of microdrops. Unique in its emphasis on digital microfluidics and with diverse applications ranging from drug delivery to point-of-care diagnostic chips, organic synthesis to microreactors, Micro-Drops and Digital Microfluidics meets the needs of audiences across the fields of bioengineering and biotechnology, and electrical and chemical engineering. Authoritative reporting on the latest changes in microfluidic science, where microscopic liquid volumes are handled as ""microdrops"" and separately from ""nanodrops." A methodical examination of how liquid microdrops behave in the complex geometries of modern miniaturized systems and interact with different morphological (micro-fabricated, textured) solid substrates A thorough explanation of how capillary forces act on liquid interfaces in contact with micro-fabricated surfaces Analysis of how droplets can be manipulated, handled, or transported using electric fields (electrowetting), acoustic actuation (surface acoustic waves), or by a carrier liquid (microflow) A fresh perspective on the future of microfluidics

Microdrops and Digital Microfluidics

Microdrops and Digital Microfluidics Book
Author : Jean Berthier
Publisher : William Andrew Pub
Release : 2008
ISBN : 9780815515449
Language : En, Es, Fr & De

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Book Description :

In this 2nd edition of Micro-Drops and Digital Microfluidics, Jean Berthier explores the fundamentals and applications of digital microfluidics, enabling engineers and scientists to design this important enabling technology into devices and harness the considerable potential of digital microfluidics in testing and data collection. This book describes the most recent developments in digital microfluidics, with a specific focus on the computational, theoretical and experimental study of microdrops. Unique in its emphasis on digital microfluidics and with diverse applications ranging from drug delivery to point-of-care diagnostic chips, organic synthesis to microreactors, Micro-Drops and Digital Microfluidics meets the needs of audiences across the fields of bioengineering and biotechnology, and electrical and chemical engineering. . Authoritative reporting on the latest changes in microfluidic science, where microscopic liquid volumes are handled as ""microdrops"" and separately from ""nanodrops."" . A methodical examination of how liquid microdrops behave in the complex geometries of modern miniaturized systems and interact with different morphological (micro-fabricated, textured) solid substrates. . A thorough explanation of how capillary forces act on liquid interfaces in contact with micro-fabricated surfaces. . Analysis of how droplets can be manipulated, handled, or transported using electric fields (electrowetting), acoustic actuation (surface acoustic waves), or by a carrier liquid (microflow). . A fresh perspective on the future of microfluidics.

Micro Drops and Digital Microfluidics

Micro Drops and Digital Microfluidics Book
Author : Jean Berthier
Publisher : Elsevier
Release : 2008-03-20
ISBN : 0815518358
Language : En, Es, Fr & De

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Book Description :

After spending over 12 years developing new microsystems for biotechnology – especially concerned with the microfluidic aspects of these devices – Jean Berthier is considered a leading authority in the field. Now, following the success of his book, Microfluidics for Biotechnology, Dr. Berthier returns to explain how new miniaturization techniques have dramatically expanded the area of microfluidic applications and microsystems into microdrops and digital microfluidics. Engineers interested in designing more versatile microsystems and students who seek to learn the fundamentals of microfluidics will all appreciate the wide-range of information found within Microdrops and Digital Microfluidics. The most recent developments in digital microfluidics are described in clear detail, with a specific focus on the computational, theoretical and experimental study of microdrops. • Over 500 equations and more than 400 illustrations. • Authoritative reporting on the latest changes in microfluidic science, where microscopic liquid volumes are handled as ""microdrops"" and separately from ""nanodrops."" • A methodical examination of how liquid microdrops behave in the complex geometries of modern miniaturized systems and interact with different morphological (micro-fabricated, textured) solid substrates. • A thorough explanation of how capillary forces act on liquid interfaces in contact with micro-fabricated surfaces. • Analysis of how droplets can be manipulated, handled, or transported using electric fields (electrowetting), acoustic actuation (surface acoustic waves), or by a carrier liquid (microflow). • A fresh perspective on the future of microfluidics.

Micro Electrode Dot Array Digital Microfluidic Biochips

Micro Electrode Dot Array Digital Microfluidic Biochips Book
Author : Zipeng Li,Krishnendu Chakrabarty,Tsung-Yi Ho,Chen-Yi Lee
Publisher : Springer
Release : 2018-12-14
ISBN : 3030029646
Language : En, Es, Fr & De

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Book Description :

This book provides an insightful guide to the design, testing and optimization of micro-electrode-dot-array (MEDA) digital microfluidic biochips. The authors focus on the characteristics specific for MEDA biochips, e.g., real-time sensing and advanced microfluidic operations like lamination mixing and droplet shape morphing. Readers will be enabled to enhance the automated design and use of MEDA and to develop a set of solutions to facilitate the full exploitation of design complexities that are possible with standard CMOS fabrication techniques. The book provides the first set of design automation and test techniques for MEDA biochips. The methods described in this book have been validated using fabricated MEDA biochips in the laboratory. Readers will benefit from an in-depth look at the MEDA platform and how to combine microfluidics with software, e.g., applying biomolecular protocols to software-controlled and cyberphysical microfluidic biochips.

VLSI Design and Test

VLSI Design and Test Book
Author : Brajesh Kumar Kaushik,Sudeb Dasgupta,Virendra Singh
Publisher : Springer
Release : 2017-12-21
ISBN : 9811074704
Language : En, Es, Fr & De

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Book Description :

This book constitutes the refereed proceedings of the 21st International Symposium on VLSI Design and Test, VDAT 2017, held in Roorkee, India, in June/July 2017. The 48 full papers presented together with 27 short papers were carefully reviewed and selected from 246 submissions. The papers were organized in topical sections named: digital design; analog/mixed signal; VLSI testing; devices and technology; VLSI architectures; emerging technologies and memory; system design; low power design and test; RF circuits; architecture and CAD; and design verification.

Fluid Mechanics and Fluid Power

Fluid Mechanics and Fluid Power Book
Author : T. Prabu,P. Viswanathan,Amit Agrawal,Jyotirmay Banerjee
Publisher : Springer Nature
Release : 2021-08-03
ISBN : 9811606986
Language : En, Es, Fr & De

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Book Description :

div="" style="" This book comprises select proceedings of the 46th National Conference on Fluid Mechanics and Fluid Power (FMFP 2019). The contents of this book focus on aerodynamics and flow control, computational fluid dynamics, fluid structure interaction, noise and aero-acoustics, unsteady and pulsating flows, vortex dynamics, nuclear thermal hydraulics, heat transfer in nanofluids, etc. This book serves as a useful reference beneficial to researchers, academicians and students interested in the broad field of mechanics. ^

Formal Modeling and Verification of Cyber Physical Systems

Formal Modeling and Verification of Cyber Physical Systems Book
Author : Rolf Drechsler,Ulrich Kühne
Publisher : Springer
Release : 2015-06-05
ISBN : 3658099941
Language : En, Es, Fr & De

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Book Description :

This book presents the lecture notes of the 1st Summer School on Methods and Tools for the Design of Digital Systems, 2015, held in Bremen, Germany. The topic of the summer school was devoted to modeling and verification of cyber-physical systems. This covers several aspects of the field, including hybrid systems and model checking, as well as applications in robotics and aerospace systems. The main chapters have been written by leading scientists, who present their field of research, each providing references to introductory material as well as latest scientific advances and future research directions. This is complemented by short papers submitted by the participating PhD students.

Green Analytical Chemistry

Green Analytical Chemistry Book
Author : Mihkel Koel,Mihkel Kaljurand
Publisher : Royal Society of Chemistry
Release : 2015-11-09
ISBN : 178262600X
Language : En, Es, Fr & De

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Book Description :

Concerns about environmental pollution, global climate change and hazards to human health have increased dramatically. This has led to a call for change in chemical processes including those that are part of chemical analysis. The development of analytical chemistry continues and every new discovery in chemistry, physics, molecular biology, and materials science brings new opportunities and challenges. Yet, contemporary analytical chemistry does not consume resources optimally. Indeed, the usage of toxic chemical compounds is at the highest rate ever. All this makes the emerging field of green chemistry a “hot topic” in industrial, governmental laboratories as well as in academia. This book starts by introducing the twelve principles of green chemistry. It then goes on to discuss how the principles of green chemistry can be used to assess the ‘greenness’ of analytical methodologies. The ‘green profile’ proposed by the ACS Green Chemistry Institute is also presented. A chapter on “Greening” sample preparation describes approaches to minimizing toxic solvent use, using non-toxic alternatives, and saving energy. The chapter on instrumental methods describes existing analytical approaches that are inherently green and making non-green methods greener. The final chapter on signal acquisition describes how quantitative structure-property relationship (QSPR) ideas could reduce experimental work thus making analysis greener. The book concludes with a discussion of how green chemistry is both possible and necessary. Green Analytical Chemistry is aimed at managers of analytical laboratories but will also interest teachers of analytical chemistry and green public policy makers.

The Physics of Microdroplets

The Physics of Microdroplets Book
Author : Jean Berthier,Kenneth A. Brakke
Publisher : John Wiley & Sons
Release : 2012-04-30
ISBN : 1118401336
Language : En, Es, Fr & De

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Book Description :

The Physics of Microdroplets gives the reader the theoretical and numerical tools to understand, explain, calculate, and predict the often nonintuitive observed behavior of droplets in microsystems. Microdrops and interfaces are now a common feature in most fluidic microsystems, from biology, to biotechnology, materials science, 3D-microelectronics, optofluidics, and mechatronics. On the other hand, the behavior of droplets and interfaces in today's microsystems is complicated and involves complex 3D geometrical considerations. From a numerical standpoint, the treatment of interfaces separating different immiscible phases is difficult. After a chapter dedicated to the general theory of wetting, this practical book successively details: The theory of 3D liquid interfaces The formulas for volume and surface of sessile and pancake droplets The behavior of sessile droplets The behavior of droplets between tapered plates and in wedges The behavior of droplets in microchannels The effect of capillarity with the analysis of capillary rise The onset of spontaneous capillary flow in open microfluidic systems The interaction between droplets, like engulfment The theory and application of electrowetting The state of the art for the approach of 3D-microelectronics using capillary alignment

Microfluidics

Microfluidics Book
Author : Yu Song,Daojian Cheng,Liang Zhao
Publisher : John Wiley & Sons
Release : 2018-05-07
ISBN : 3527341064
Language : En, Es, Fr & De

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Book Description :

The first book offering a global overview of fundamental microfluidics and the wide range of possible applications, for example, in chemistry, biology, and biomedical science. As such, it summarizes recent progress in microfluidics, including its origin and development, the theoretical fundamentals, and fabrication techniques for microfluidic devices. The book also comprehensively covers the fluid mechanics, physics and chemistry as well as applications in such different fields as detection and synthesis of inorganic and organic materials. A useful reference for non-specialists and a basic guideline for research scientists and technicians already active in this field or intending to work in microfluidics.

Microfluidics for Biotechnology

Microfluidics for Biotechnology Book
Author : Jean Berthier,Pascal Silberzan
Publisher : Artech House
Release : 2010
ISBN : 1596934441
Language : En, Es, Fr & De

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Book Description :

The application of microfluidics to biotechnology is an exciting new area that has already begun to revolutionize how researchers study and manipulate macromolecules like DNA, proteins and cells in vitro and within living organisms. Now in a newly revised and expanded second edition, the Artech House bestseller, Microfluidics for Biotechnology brings you to the cutting edge of this burgeoning field. Among the numerous updates, the second edition features three entirely new chapters on: non-dimensional numbers in microfluidics; interface, capillarity and microdrops; and digital, two-phase and droplet microfluidics.Presenting an enlightening balance of numerical approaches, theory, and experimental examples, this book provides a detailed look at the mechanical behavior of the different types of micro/nano particles and macromolecules that are used in biotechnology. You gain a solid understanding of microfluidics theory and the mechanics of microflows and microdrops. The book examines the diffusion of species and nanoparticles, including continuous flow and discrete Monte-Carlo methods.This unique volume describes the transport and dispersion of biochemical species and particles. You learn how to model biochemical reactions, including DNA hybridization and enzymatic reactions. Moreover, the book helps you master the theory, applications, and modeling of magnetic beads behavior and provides an overview of self-assembly and magnetic composite. Other key topics include the electric manipulation of micro/nanoparticles and macromolecules and the experimental aspects of biological macromolecule manipulation.

Digital Microfluidic Biochips

Digital Microfluidic Biochips Book
Author : Krishnendu Chakrabarty,Fei Su
Publisher : CRC Press
Release : 2018-10-03
ISBN : 1420008307
Language : En, Es, Fr & De

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Book Description :

Digital Microfluidic Biochips focuses on the automated design and production of microfluidic-based biochips for large-scale bioassays and safety-critical applications. Bridging areas of electronic design automation with microfluidic biochip research, the authors present a system-level design automation framework that addresses key issues in the design, analysis, and testing of digital microfluidic biochips. The book describes a new generation of microfluidic biochips with more complex designs that offer dynamic reconfigurability, system scalability, system integration, and defect tolerance. Part I describes a unified design methodology that targets design optimization under resource constraints. Part II investigates cost-effective testing techniques for digital microfluidic biochips that include test resource optimization and fault detection while running normal bioassays. Part III focuses on different reconfiguration-based defect tolerance techniques designed to increase the yield and dependability of digital microfluidic biochips. Expanding upon results from ongoing research on CAD for biochips at Duke University, this book presents new design methodologies that address some of the limitations in current full-custom design techniques. Digital Microfluidic Biochips is an essential resource for achieving the integration of microfluidic components in the next generation of system-on-chip and system-in-package designs.

Advances in Microfluidics

Advances in Microfluidics Book
Author : Xiao-Ying Yu
Publisher : BoD – Books on Demand
Release : 2016-11-23
ISBN : 9535127853
Language : En, Es, Fr & De

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Book Description :

Increasing innovations and applications make microfluidics a versatile choice for researchers in many disciplines. This book consists of multiple review chapters that aim to cover recent advances and new applications of microfluidics in biology, electronics, energy, and materials sciences. It provides comprehensive views of various aspects of microfluidics ranging from fundamentals of fabrication, flow control, and droplet manipulation to the most recent exploration in emerging areas such as material synthesis, imaging and novel spectroscopy, and marriage with electronics. The chapters have many illustrations showcasing exciting results. This book should be useful for those who are eager to learn more about microfluidics as well as researchers who want to pick up new concepts and developments in this fast-growing field.

Droplet Microfluidics

Droplet Microfluidics Book
Author : Abraham Lee,Carolyn Ren
Publisher : Royal Society of Chemistry
Release : 2020-11-27
ISBN : 1788017692
Language : En, Es, Fr & De

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Book Description :

Edited by two leaders, this book has drawn together expertise from around the globe to form a unified, cohesive resource for the droplet microfluidics community. Starting with the basic theory of droplet microfluidics before introducing its use as a tool, the reader is treated to chapters on important techniques, including robust passive and active droplet manipulations and applications such as single cell analysis, which is key for drug discovery. This book is a go-to resource for the community yearning to adopt and promote droplet microfluidics into different applications.

Microfluidics Modeling Mechanics and Mathematics

Microfluidics  Modeling  Mechanics and Mathematics Book
Author : Bastian E. Rapp
Publisher : William Andrew
Release : 2016-12-13
ISBN : 145573151X
Language : En, Es, Fr & De

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Book Description :

This practical, lab-based approach to nano- and microfluidics provides readers with a wealth of practical techniques, protocols, and experiments ready to be put into practice in both research and industrial settings. The practical approach is ideally suited to researchers and R&D staff in industry; additionally the interdisciplinary approach to the science of nano- and microfluidics enables readers from a range of different academic disciplines to broaden their understanding. Dr Rapp fully engages with the multidisciplinary nature of the subject. Alongside traditional fluid/transport topics, there is a wealth of coverage of materials and manufacturing techniques, chemical modification/surface functionalization, biochemical analysis, and the biosensors involved. As well as providing a clear and concise overview to get started into the multidisciplinary field of microfluidics and practical guidance on techniques, pitfalls and troubleshooting, this book supplies: A set of hands-on experiments and protocols that will help setting up lab experiments but which will also allow a quick start into practical work. A collection of microfluidic structures, with 3D-CAD and image data that can be used directly (files provided on a companion website). A practical guide to the successful design and implementation of nano- and microfluidic processes (e.g. biosensing) and equipment (e.g., biosensors, such as diabetes blood glucose sensors). Provides techniques, experiments, and protocols ready to be put to use in the lab, in an academic, or industry setting. A collection of 3D-CAD and image files is provided on a companion website.

Open Channel Microfluidics

Open Channel Microfluidics Book
Author : Jean Berthier,Ashleigh B Theberge,Erwin Berthier
Publisher : Morgan & Claypool Publishers
Release : 2019-09-04
ISBN : 1643276646
Language : En, Es, Fr & De

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Book Description :

Open microfluidics, the study of microflows having a boundary with surrounding air, encompasses different aspects such as paper or thread-based microfluidics, droplet microfluidics and open-channel microfluidics. Open-channel microflow is a flow at the micro-scale, guided by solid structures, and having at least a free boundary (with air or vapor) other than the advancing meniscus. This book is devoted to the study of open-channel microfluidics which (contrary to paper or thread or droplet microfluidics) is still very sparsely documented, but bears many new applications in biology, biotechnology, medicine, material and space sciences. Capillarity being the principal force triggering an open microflow, the principles of capillarity are first recalled. The onset of open-channel microflow is next analyzed and the fundamental notion of generalized Cassie angle (the apparent contact angle which accounts for the presence of air) is presented. The theory of the dynamics of open-channel microflows is then developed, using the notion of averaged friction length which accounts for the presence of air along the boundaries of the flow domain. Different channel morphologies are studied and geometrical features such as valves and capillary pumps are examined. An introduction to two-phase open-channel microflows is also presented showing that immiscible plugs can be transported by an open-channel flow. Finally, a selection of interesting applications in the domains of space, materials, medicine and biology is presented, showing the potentialities of open-channel microfluidics.

Microfluidic Devices for Biomedical Applications

Microfluidic Devices for Biomedical Applications Book
Author : Xiujun James Li,Yu Zhou
Publisher : Elsevier
Release : 2013-10-31
ISBN : 0857097040
Language : En, Es, Fr & De

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Book Description :

Microfluidics or lab-on-a-chip (LOC) is an important technology suitable for numerous applications from drug delivery to tissue engineering. Microfluidic devices for biomedical applications discusses the fundamentals of microfluidics and explores in detail a wide range of medical applications. The first part of the book reviews the fundamentals of microfluidic technologies for biomedical applications with chapters focussing on the materials and methods for microfabrication, microfluidic actuation mechanisms and digital microfluidic technologies. Chapters in part two examine applications in drug discovery and controlled-delivery including micro needles. Part three considers applications of microfluidic devices in cellular analysis and manipulation, tissue engineering and their role in developing tissue scaffolds and stem cell engineering. The final part of the book covers the applications of microfluidic devices in diagnostic sensing, including genetic analysis, low-cost bioassays, viral detection, and radio chemical synthesis. Microfluidic devices for biomedical applications is an essential reference for medical device manufacturers, scientists and researchers concerned with microfluidics in the field of biomedical applications and life-science industries. Discusses the fundamentals of microfluidics or lab-on-a-chip (LOC) and explores in detail a wide range of medical applications Considers materials and methods for microfabrication, microfluidic actuation mechanisms and digital microfluidic technologies Considers applications of microfluidic devices in cellular analysis and manipulation, tissue engineering and their role in developing tissue scaffolds and stem cell engineering

Encyclopedia of Microfluidics and Nanofluidics

Encyclopedia of Microfluidics and Nanofluidics Book
Author : Dongqing Li
Publisher : Springer Science & Business Media
Release : 2008-08-06
ISBN : 0387324682
Language : En, Es, Fr & De

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Book Description :

Covering all aspects of transport phenomena on the nano- and micro-scale, this encyclopedia features over 750 entries in three alphabetically-arranged volumes including the most up-to-date research, insights, and applied techniques across all areas. Coverage includes electrical double-layers, optofluidics, DNC lab-on-a-chip, nanosensors, and more.

Microfluidics for Biotechnology

Microfluidics for Biotechnology Book
Author : Jean Berthier,Pascal Silberzan
Publisher : Artech House Publishers
Release : 2010
ISBN : 9781596934436
Language : En, Es, Fr & De

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Book Description :

The application of microfluidics to biotechnology is an exciting new area that has already begun to revolutionize how researchers study and manipulate macromolecules like DNA, proteins and cells in vitro and within living organisms. Now in a newly revised and expanded second edition, the Artech House bestseller, Microfluidics for Biotechnology brings you to the cutting edge of this burgeoning field. Among the numerous updates, the second edition features three entirely new chapters on: non-dimensional numbers in microfluidics; interface, capillarity and microdrops; and digital, two-phase and droplet microfluidics. Presenting an enlightening balance of numerical approaches, theory, and experimental examples, this book provides a detailed look at the mechanical behavior of the different types of micro/nano particles and macromolecules that are used in biotechnology. You gain a solid understanding of microfluidics theory and the mechanics of microflows and microdrops. The book examines the diffusion of species and nanoparticles, including continuous flow and discrete Monte-Carlo methods. This unique volume describes the transport and dispersion of biochemical species and particles. You learn how to model biochemical reactions, including DNA hybridization and enzymatic reactions. Moreover, the book helps you master the theory, applications, and modeling of magnetic beads behavior and provides an overview of self-assembly and magnetic composite. Other key topics include the electric manipulation of micro/nanoparticles and macromolecules and the experimental aspects of biological macromolecule manipulation.

Microdroplet Technology

Microdroplet Technology Book
Author : Philip Day,Andreas Manz,Yonghao Zhang
Publisher : Springer Science & Business Media
Release : 2012-07-28
ISBN : 1461432650
Language : En, Es, Fr & De

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Book Description :

Microdroplet technology has recently emerged to provide new and diverse applications via microfluidic functionality, especially in various areas of biology and chemistry. This book, then, gives an overview of the principle components and wide-ranging applications for state-of-the-art of droplet-based microfluidics. Chapter authors are internationally-leading researchers from chemistry, biology, physics and engineering that present various key aspects of micrdroplet technology -- fundamental flow physics, methodology and components for flow control, applications in biology and chemistry, and a discussion of future perspectives. This book acts as a reference for academics, post-graduate students, and researcher wishing to deepen their understand of microfluidics and introduce optimal design and operation of new droplet-based microfluidic devices for more comprehensive analyte assessments.