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Metagenomics Techniques Applications Challenges and Opportunities

Metagenomics  Techniques  Applications  Challenges and Opportunities Book
Author : Reena Singh Chopra,Chirag Chopra,Neeta Raj Sharma
Publisher : Springer Nature
Release : 2020-09-08
ISBN : 9811565295
Language : En, Es, Fr & De

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Book Description :

This book summarizes the various areas of research in metagenomics and their potential applications in medicine, the environment and biotechnology. The book presents the recent advances in theoretical, methodological and applied aspects of metagenomics and highlights their applications in the fields of environmental microbial forensics, bioremediation, drug-discovery and agriculture. In addition, the book discusses various metagenomics approaches used for understanding the microbial physiology and biochemistry. Lastly the book describes a range of bioinformatics tools and computational methods for metagenomics analysis as well as the functional diversity and dynamics of microbial communities colonizing the human skin.

Metagenomics

Metagenomics Book
Author : Muniyandi Nagarajan
Publisher : Academic Press
Release : 2017-10-29
ISBN : 9780081022689
Language : En, Es, Fr & De

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Book Description :

Metagenomics: Perspectives, Methods, and Applications provides thorough coverage of the rapidly growing field of metagenomics. A diverse range of chapters from international experts offers an introduction to the field and examines methods for metagenomic analysis of microbiota, metagenomic computational tools and pipelines, and recent metagenomic studies in various environments. The emphasis on application makes this text particularly useful for translational researchers, clinicians, and students seeking to employ metagenomic approaches to advance knowledge in the biomedical and life sciences. Case study-based chapters explore topics ranging from viral metagenome profiling to metagenomic insights into the human oral and gut microbiome and metabolic syndromes, functional annotation of metagenomes, and metagenomic analysis of extreme environments. Additionally, perspectives on future potential instill motivation for continued study in this exciting and fruitful research area.

Viral Metagenomics

Viral Metagenomics Book
Author : Vitantonio Pantaleo,Michela Chiumenti
Publisher : Humana
Release : 2019-03-17
ISBN : 9781493992577
Language : En, Es, Fr & De

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Book Description :

This volume explores the use of viral metagenomics to diagnose known viruses for plant and food production, human and animal health, and identifying viral vectors like insects. The chapters in this book cover topics, such as sRNAs isolation from tissues of grapevines and woody plants, high-resolution screening of arthropod and plant viral communities, identifying new pathogens in fish, detecting viruses in mycorrhizal fungi and their orchid host, and insect virus discovery through metagenomic and cell culture-based approaches. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and comprehensive, Viral Metagenomics: Methods and Protocols is a valuable resource for researchers and specialists who are interested in learning more about this evolving field.

Metagenomics for Microbiology

Metagenomics for Microbiology Book
Author : Jacques Izard,Maria Rivera,Maria C. Rivera
Publisher : Academic Press
Release : 2014-10-13
ISBN : 9780124104723
Language : En, Es, Fr & De

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Book Description :

Concisely discussing the application of high throughput analysis to move forward our understanding of microbial principles, Metagenomics for Microbiology provides a solid base for the design and analysis of omics studies for the characterization of microbial consortia. The intended audience includes clinical and environmental microbiologists, molecular biologists, infectious disease experts, statisticians, biostatisticians, and public health scientists. This book focuses on the technological underpinnings of metagenomic approaches and their conceptual and practical applications. With the next-generation genomic sequencing revolution increasingly permitting researchers to decipher the coding information of the microbes living with us, we now have a unique capacity to compare multiple sites within individuals and at higher resolution and greater throughput than hitherto possible. The recent articulation of this paradigm points to unique possibilities for investigation of our dynamic relationship with these cellular communities, and excitingly the probing of their therapeutic potential in disease prevention or treatment of the future. Expertly describes the latest metagenomic methodologies and best-practices, from sample collection to data analysis for taxonomic, whole shotgun metagenomic, and metatranscriptomic studies Includes clear-headed pointers and quick starts to direct research efforts and increase study efficacy, eschewing ponderous prose Presented topics include sample collection and preparation, data generation and quality control, third generation sequencing, advances in computational analyses of shotgun metagenomic sequence data, taxonomic profiling of shotgun data, hypothesis testing, and mathematical and computational analysis of longitudinal data and time series. Past-examples and prospects are provided to contextualize the applications.

The New Science of Metagenomics

The New Science of Metagenomics Book
Author : National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on Metagenomics: Challenges and Functional Applications
Publisher : National Academies Press
Release : 2007-05-24
ISBN : 9780309185752
Language : En, Es, Fr & De

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Book Description :

Although we can't usually see them, microbes are essential for every part of human life -- indeed all life on Earth. The emerging field of metagenomics offers a new way of exploring the microbial world that will transform modern microbiology and lead to practical applications in medicine, agriculture, alternative energy, environmental remediation, and many others areas. Metagenomics allows researchers to look at the genomes of all of the microbes in an environment at once, providing a "meta" view of the whole microbial community and the complex interactions within it. It's a quantum leap beyond traditional research techniques that rely on studying -- one at a time -- the few microbes that can be grown in the laboratory. At the request of the National Science Foundation, five Institutes of the National Institutes of Health, and the Department of Energy, the National Research Council organized a committee to address the current state of metagenomics and identify obstacles current researchers are facing in order to determine how to best support the field and encourage its success. The New Science of Metagenomics recommends the establishment of a "Global Metagenomics Initiative" comprising a small number of large-scale metagenomics projects as well as many medium- and small-scale projects to advance the technology and develop the standard practices needed to advance the field. The report also addresses database needs, methodological challenges, and the importance of interdisciplinary collaboration in supporting this new field.

Metagenomics Methods and Protocols

Metagenomics  Methods and Protocols Book
Author : Wolfgang R. Streit,Rolf Daniel
Publisher : Methods in Molecular Biology
Release : 2018-12-14
ISBN : 9781493982745
Language : En, Es, Fr & De

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Book Description :

Download Metagenomics Methods and Protocols book written by Wolfgang R. Streit,Rolf Daniel, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Heterologous Expression in the Metagenomics Era

Heterologous Expression in the Metagenomics Era Book
Author : Zakee Louis Sabree
Publisher : Unknown
Release : 2007
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Heterologous Expression in the Metagenomics Era book written by Zakee Louis Sabree, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Metagenomics of the Human Body

Metagenomics of the Human Body Book
Author : Karen E. Nelson
Publisher : Springer Science & Business Media
Release : 2010-11-16
ISBN : 9781441970893
Language : En, Es, Fr & De

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Book Description :

The book brings a completely different perspective than available books by combining the information gained from the human genome with that derived from parallel metagenomic studies, and new results from investigating the effects of these microbes on the host immune system. Although there are a number of books that focus on the human genome that are currently available, there are no books that bring to the forefront the mix of the human genome and the genomes and metagenomes of the microbial species that live within and on us.

Metagenomics

Metagenomics Book
Author : Wael N. Hozzein
Publisher : BoD – Books on Demand
Release : 2020-03-25
ISBN : 1838800557
Language : En, Es, Fr & De

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Book Description :

This book is for the students starting their research projects in the field of metagenomics, for researchers interested in the new developments and applications in this field; and for teachers involved in teaching this subject. The book is divided into three sections as indicated from its title, namely; the basics of metagenomics, metagenomic analysis, and applications of metagenomics. It covers the basics of metagenomics from its history and background, to the analysis of metagenomic data as well as its recent applications in different fields. The book contains excellent texts at both the introductory and advanced levels, that describe the latest metagenomic approaches and applications, from sampling to data analysis for taxonomic, environmental, and medical studies. Finally, the publication of this book was an interesting journey for me and I hope the readers will enjoy reading it.

Metagenomics

Metagenomics Book
Author : Muniyandi Nagarajan
Publisher : Academic Press
Release : 2017-11-06
ISBN : 0128134038
Language : En, Es, Fr & De

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Book Description :

Metagenomics: Perspectives, Methods, and Applications provides thorough coverage of the growing field of metagenomics. A diverse range of chapters from international experts offer an introduction to the field and examine methods for metagenomic analysis of microbiota, metagenomic computational tools, and recent metagenomic studies in various environments. The emphasis on application makes this text particularly useful for applied researchers, practitioners, clinicians and students seeking to employ metagenomic approaches to advance knowledge in the biomedical and life sciences. Case-study based application chapters examine topics ranging from viral metagenome profiling, metagenomics in oral disease and health, metagenomic insights into the human gut microbiome and metabolic syndromes, and more. Additionally, perspectives on future potential at the end of each chapter provoke new thought and motivations for continued study in this exciting and fruitful research area. Provides thorough coverage of the rapidly growing field of metagenomics, with an emphasis on applications of relevance to translational researchers, practitioners, clinicians and students Features a diverse range of chapters from international experts that offer an introduction to the field and examine methods for metagenomic analysis of microbiota, metagenomic computational tools and research pipelines Highlights perspectives on future potential at the end of each chapter to provoke new thought and motivations for continued study in this exciting and fruitful research area

Using Genomics Metagenomics and Other Omics to Assess Valuable Microbial Ecosystem Services and Novel Biotechnological Applications

Using Genomics  Metagenomics and Other  Omics  to Assess Valuable Microbial Ecosystem Services and Novel Biotechnological Applications Book
Author : Diana Elizabeth Marco,Florence Abram
Publisher : Frontiers Media SA
Release : 2019-05-15
ISBN : 2889458148
Language : En, Es, Fr & De

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Book Description :

Most ecosystem services and goods human populations use and consume are provided by microbial populations and communities. Indeed, numerous provisioning services (e.g. food and enzymes for industrial processes), regulating services (e.g. water quality, contamination alleviation and biological processes such as plant-microbial symbioses), and supporting services (e.g. nutrient cycling, agricultural production and biodiversity) are mediated by microbes. The fast development of metagenomics and other meta-omics technologies is expanding our understanding of microbial diversity, ecology, evolution and functioning. This enhanced knowledge directly translates into the emergence of new applications in an unlimited variety of areas across all microbial ecosystem services and goods. The varied topics addressed in this Research Topic include the development of innovative industrial processes, the discovery of novel natural products, the advancement of new agricultural methods, the amelioration of negative effects of productive or natural microbiological processes, as well as food security and human health, and archeological conservation. The articles compiled provide an updated, high-quality overview of current work in the field. This body of research makes a valuable contribution to the understanding of microbial ecosystem services, and expands the horizon for finding and developing new and more efficient biotechnological applications.

Handbook of Molecular Microbial Ecology II

Handbook of Molecular Microbial Ecology II Book
Author : Frans J. de Bruijn
Publisher : John Wiley & Sons
Release : 2011-09-27
ISBN : 0470647191
Language : En, Es, Fr & De

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Book Description :

"Handbook of Molecular Microbial Ecology I: Metagenomics and Complementary Approaches is the first comprehensive reference covering the various metagenomics in a large variety of habitats, which could not previously have been analysed without metagenomic methodology. This Volume includes topics such as species designations in microbiology, metagenomics, consortia and databases, bioinformatics, microarrays, and other metagenomics applications. This reference is ideal for researchers in metagenomics, microbiology, environmental microbiology, those working on the Human Microbiome Project, microbial geneticists, molecular microbiology, and bioinformatics"--

Handbook of Molecular Microbial Ecology I

Handbook of Molecular Microbial Ecology I Book
Author : Frans J. de Bruijn
Publisher : John Wiley & Sons
Release : 2011-10-14
ISBN : 1118010493
Language : En, Es, Fr & De

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Book Description :

The premiere two-volume reference on revelations from studying complex microbial communities in many distinct habitats Metagenomics is an emerging field that has changed the way microbiologists study microorganisms. It involves the genomic analysis of microorganisms by extraction and cloning of DNA from a group of microorganisms, or the direct use of the purified DNA or RNA for sequencing, which allows scientists to bypass the usual protocol of isolating and culturing individual microbial species. This method is now used in laboratories across the globe to study microorganism diversity and for isolating novel medical and industrial compounds. Handbook of Molecular Microbial Ecology is the first comprehensive two-volume reference to cover unculturable microorganisms in a large variety of habitats, which could not previously have been analyzed without metagenomic methodology. It features review articles as well as a large number of case studies, based largely on original publications and written by international experts. This first volume, Metagenomics and Complementary Approaches, covers such topics as: Background information on DNA reassociation and use of 16 rRNA and other DNA fingerprinting approaches Species designation in microbiology Metagenomics: Introduction to the basic tools with examples Consortia and databases Bioinformatics Computer-assisted analysis Complementary approaches—microarrays, metatranscriptomics, metaproteomics, metabolomics, and single cell analysis A special feature of this volume is the highlighting of the databases and computer programs used in each study; they are listed along with their sites in order to facilitate the computer-assisted analysis of the vast amount of data generated by metagenomic studies. Handbook of Molecular Microbial Ecology I is an invaluable reference for researchers in metagenomics, microbiology, and environmental microbiology; those working on the Human Microbiome Project; microbial geneticists; molecular microbial ecologists; and professionals in molecular microbiology and bioinformatics.

Metagenomics for Gut Microbes

Metagenomics for Gut Microbes Book
Author : Ranjith Kumavath
Publisher : BoD – Books on Demand
Release : 2018-05-09
ISBN : 1789231108
Language : En, Es, Fr & De

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Book Description :

This book focuses on metagenomics for gut microbiomes. The host is deprived of various benefits derived from the numerous gut microbes for food metabolism and health. However, polysaccharides such as cellulose, xylans, resistant starch, and inulin that are found in vegetables in our diet are digested by certain species that colonize the intestines. In contrast, metagenomic studies that reiterate microbiome intrinsic factors from particular communities and lifestyles and are extremely important for bacterial communities traveling over a long distance have entered a new era. Predominantly to understand the behavior of organisms and their action in a host, next-generation sequencing will provide a new insight into analyzing the livestock industry, agriculture, and human health risks and will consider for future development novel therapies for various diseases through identification of advanced tools. Hence, the book will give more precise information on the role of gut microbiomes in the host.

Functional Metagenomics Tools and Applications

Functional Metagenomics  Tools and Applications Book
Author : Trevor C. Charles,Mark R. Liles,Angela Sessitsch
Publisher : Springer
Release : 2017-10-09
ISBN : 3319615106
Language : En, Es, Fr & De

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Book Description :

In this book, the latest tools available for functional metagenomics research are described.This research enables scientists to directly access the genomes from diverse microbial genomes at one time and study these “metagenomes”. Using the modern tools of genome sequencing and cloning, researchers have now been able to harness this astounding metagenomic diversity to understand and exploit the diverse functions of microorganisms. Leading scientists from around the world demonstrate how these approaches have been applied in many different settings, including aquatic and terrestrial habitats, microbiomes, and many more environments. This is a highly informative and carefully presented book, providing microbiologists with a summary of the latest functional metagenomics literature on all specific habitats.

Virus Discovery by Metagenomics The Im possibilities

Virus Discovery by Metagenomics  The  Im possibilities Book
Author : Bas E. Dutilh,Alejandro Reyes,Richard J. Hall,Katrine L. Whiteson
Publisher : Frontiers Media SA
Release : 2017-10-25
ISBN : 2889453081
Language : En, Es, Fr & De

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Book Description :

Since the late 1800s, the discovery of new viruses was a gradual process. Viruses were described one by one using a suite of techniques such as (electron) microscopy and viral culture. Investigators were usually interested in a disease state within an organism, and expeditions in viral ecology were rare. The advent of metagenomics using high-throughput sequencing has revolutionized not only the rate of virus discovery, but also the nature of the discoveries. For example, the viral ecology and etiology of many human diseases are being characterized, non-pathogenic viral commensals are ubiquitous, and the description of environmental viromes is making progress. This Frontiers in Virology Research Topic showcases how metagenomic and bioinformatic approaches have been combined to discover, classify and characterize novel viruses.

Enzyme Technologies

Enzyme Technologies Book
Author : Wu-Kuang Yeh,Hsiu-Chiung Yang,James R. McCarthy
Publisher : John Wiley & Sons
Release : 2011-09-28
ISBN : 0470627298
Language : En, Es, Fr & De

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Book Description :

An authoritative review of the latest developments in the chemical biology of enzymes In the first decade of the twenty-first century, enzymes and their multiple applications have played a critical role in the discovery and development of many new therapeutic agents.This book is a coordinated compilation of research expertise and current opinion uniquely focused on enzymes and their properties and applications. Compiled by editors with a combined pharmaceutical experience of over sixty years, the text provides in-depth reviews of recent developments in selective topics on biosynthesis, biocatalysis, and chemical biology of enzymes as it applies to drug discovery, development, and manufacture. The first in a multi-part series on enzymes, this volume features three sections: New Approaches to Find and Modify Enzymes describes the emerging field of metagenomics, presents the practical applications of directed evolution to enzymes and pathways, and explores approaches for the discovery and design of biocatalysts Biocatalytic Applications reviews specific applications of different reactions in producing active pharmaceutical ingredients and surveys recent developments employing enzymes in organic synthesis Biosynthetic Applications goes over successful drug discoveries and developments by combinatorial biosynthesis and reviews the application of combinatorial biosynthesis among multiple compatible hosts These timely discussions, which cover everything from chemical biology of enzymes, to the redesign of binding and catalytic specificities of enzymes, make this volume a valuable tool for keeping up to date. As such, it is an important read for researchers, students, and professors in the study of biotechnology, life sciences, biochemistry, enzymology, medicinal chemistry, and natural products.

Encyclopedia of Metagenomics

Encyclopedia of Metagenomics Book
Author : Karen E. Nelson
Publisher : Springer
Release : 2015-01-22
ISBN : 9781489974792
Language : En, Es, Fr & De

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Book Description :

Metagenomics has taken off as one of the major cutting-edge fields of research. The field has broad implications for human health and disease, animal production and environmental health. Metagenomics has opened up a wealth of data, tools, technologies and applications that allow us to access the majority of organisms that we still cannot access in pure culture (an estimated 99% of microbial life). Numerous research groups are developing tools, approaches and applications to deal with this new field, as larger data sets from environments including the human body, the oceans and soils are being generated. See for example the human microbiome initiative (HMP) which has become a world-wide effort and the Global Ocean Sampling (GOS) surveys. The number of publications as measured through PubMed that are focused on metagenomics continues to increase. The field of metagenomics continues to evolve with large common datasets available to the scientific community. A concerted effort is needed to collate all this information in a centralized place. By having all the information in an Encyclopedia form, we have an opportunity to gather seminal contributions from the leaders in the field, and at the same time provide this information to a significant number of junior and senior scientists. It is anticipated that the Encyclopedia will also be used by many other groups including, clinicians, undergraduate and graduate level students, as well as ethical and legal groups associated with or interested in the issues surrounding metagenome science.

Marine Metagenomics

Marine Metagenomics Book
Author : Takashi Gojobori,Tokio Wada,Takanori Kobayashi,Katsuhiko Mineta
Publisher : Springer
Release : 2019-07-24
ISBN : 9811381348
Language : En, Es, Fr & De

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Book Description :

This book presents the state-of-art marine metagenome research and explains the method of marine metagenomic analysis in an easy-to-understand manner. Changes in the marine environment due to global warming and pollution have become a major global problem. Maintaining a healthy marine ecosystem requires advanced environmental monitoring and assessment systems. As such, the book presents a novel metagenomic monitoring method, which has been developed for comprehensive analyses of the DNA of microorganisms living in seawater to further our understanding of the dynamics of the marine environment. The book can be used as a primer for new researchers and as a manual on experimental methods.