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Metabolomics for Biomedical Research

Metabolomics for Biomedical Research Book
Author : Jerzy Adamski
Publisher : Academic Press
Release : 2020-04
ISBN : 0128127848
Language : En, Es, Fr & De

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Book Description :

Metabolomics for Biomedical Research brings together recent progress on study design, analytics, biostatistics and bioinformatics for the success of metabolomics research. Metabolomics represents a very interdisciplinary research prominent in the functional analyses of living systems; hence, this book focuses on translation and medical aspects. The book discusses topics such as biomarkers and their requirements to be used in medical research, with the parameters and approaches on how to validate their quality; and animal models and other approaches, as stem cells and organoid culture. Additionally, it explains how metabolomics may be applied in prediction of individual response to drug or disease progression. This book is a valuable source for researchers on systems biology and other members of biomedical field interested in metabolism-oriented studies for medical research.

Metabolomics for Biomedical Research

Metabolomics for Biomedical Research Book
Author : Jerzy Adamski
Publisher : Academic Press
Release : 2020-03-20
ISBN : 0128127856
Language : En, Es, Fr & De

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Book Description :

Metabolomics for Biomedical Research brings together recent progress on study design, analytics, biostatistics and bioinformatics for the success of metabolomics research. Metabolomics represents a very interdisciplinary research prominent in the functional analyses of living systems; hence, this book focuses on translation and medical aspects. The book discusses topics such as biomarkers and their requirements to be used in medical research, with the parameters and approaches on how to validate their quality; and animal models and other approaches, as stem cells and organoid culture. Additionally, it explains how metabolomics may be applied in prediction of individual response to drug or disease progression. This book is a valuable source for researchers on systems biology and other members of biomedical field interested in metabolism-oriented studies for medical research. Focuses on metabolomics in translational and medical research Provides basics for, and concepts of, contemporary translational personalized medicine research with metabolomics Brings the major recent progresses on design, analytics, biostatistics and bioinformatics relating to the success of metabolomics research

Advancements of Mass Spectrometry in Biomedical Research

Advancements of Mass Spectrometry in Biomedical Research Book
Author : Alisa G. Woods,Costel C. Darie
Publisher : Springer
Release : 2019-07-25
ISBN : 3030159507
Language : En, Es, Fr & De

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Book Description :

This volume explores the use of mass spectrometry for biomedical applications. Chapters focus on specific therapeutic areas such as oncology, infectious disease, and psychiatry. Additional chapters focus on methodology, technologies and instrumentation, as well as on analysis of protein-protein interactions, protein quantitation, and protein post-translational modifications. Various omics fields such as proteomics, metabolomics, glycomics, lipidomics, and adductomics are also covered. Applications of mass spectrometry in biotechnological and pharmaceutical industry are also discussed. This volume provides readers with a comprehensive and informative manual that will allow them to appreciate mass spectrometry and proteomic research, but also to initiate and improve their own work. This book acts as a technical guide as well as a conceptual guide to the newest information in this exciting field.

Metabolomics Perspectives

Metabolomics Perspectives Book
Author : Jacopo Troisi
Publisher : Academic Press
Release : 2021-12-15
ISBN : 9780323850629
Language : En, Es, Fr & De

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Book Description :

Metabolomics Perspectives: From Theory to Practical Application provides a thorough overview of metabolomics fundamentals, techniques, data analytics approaches, and their direct applications in the life sciences, medicine and industry. The book begins with metabolomic profiling methods and data analysis approaches, followed by descriptions and guidance for applying metabolomics in biomedicine, drug discovery, public health, precision medicine, plant, food science, agriculture, and cell biology and microbiology, among other disciplines. In addition, methods and protocol instructions are provided on experimental design, mass spectrometry, NMR, neonatal screening, metabolomics standardization, and metabolomic profiling in life science research and biomarker discovery. Guidance in network analysis, use of R codes, univariate analysis, square discriminant analysis, random forest, support vectoral machine, artificial neural network, ensembling, and genetic algorithms is also included. Finally, the book features a pool of specifically designed commented codes (R scripts) and several sets of metabolomics data that is hosted on a companion website. Describes metabolomics approaches across a range of applications, including life science and biomedical research, drug discovery, food and agriculture and microbiology Features chapter contributions from international leaders in the field Includes commented codes (R scripts) and several sets of metabolomics data hosted on a companion website

Untargeted Metabolomics to Assess Metabolic Consequences of Gene Mutations in Early Stage Murine Embryos and Bacteria

Untargeted Metabolomics to Assess Metabolic Consequences of Gene Mutations in Early Stage Murine Embryos and Bacteria Book
Author : Alex Robert Hansler,Cornell University. Weill Cornell Graduate School of Medical Sciences
Publisher : Unknown
Release : 2014
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Metabolomics, the study of small molecule metabolites, is an emerging "omics" field that defines one of the major next-generation approaches in systems biology. By revealing a comprehensive snapshot of all metabolic processes occurring in a biological system, metabolomic-based investigations have potential to inform science and medicine as to the molecular mechanisms underlying physiological function and dysfunction. In this thesis research, I present my work using innovative high-performance liquid chromatography-mass spectrometry (LC-MS)-based metabolomic technologies to approach complex biological questions. I explore the molecular basis of structural birth defects in early-stage murine embryos as well as critical mechanisms of radioresistance in the extremeophilic bacterium Deinococcus radiodurans (Drad). Metabolomic analyses assisted in the determination of metabolic abnormalities that were unique to neural tube defect (NTD)-affected murine embryos. Differentially expressed metabolites in NTD-affected embryos were related to folate-regulated one-carbon metabolism pathways, substantiating findings of gene expression profiling studies as well as partially explaining the observed folate-responsiveness of these birth defects. Notably, these studies established proof-of-principle for using whole-embryo metabolomics to study consequences of gene mutation in early development. Additionally, untargeted metabolomics provided critical insight as to the metabolic basis for radioprotection afforded by endogenous nitric oxide (NO) in Drad. In particular, endogenous NO was found to be essential for maintaining the physiological pattern of carotenoid biosynthesis, an activity that likely is fundamental for the extreme radioresistance of this bacterium. Furthermore, untargeted metabolite profiling allowed the membrane composition of wild type Drad to be redefined and led to our discovery of carotenoid-glucosides-- previously unknown membrane lipids in Drad whose abundances were altered by endogenous NO production. Additional examination of mechanisms of radioresistance in Drad may provide novel strategies to reduce radiation damage in higher organisms or conversely lead to enhanced approaches to sensitize mammalian tumors to radiotherapy. In these studies, LC-MS-based untargeted metabolite profiling proved to be an indispensable tool for determining the physiological consequences of gene mutation. Further, these experiments demonstrate the utility of untargeted metabolomics in biomedical research; metabolomics datasets provide powerful and robust explanations of phenotype and will allow the advancement of our understanding of biology and disease from a systematic viewpoint.

Pediatric Biomedical Informatics

Pediatric Biomedical Informatics Book
Author : John J. Hutton
Publisher : Springer Science & Business Media
Release : 2012-12-13
ISBN : 9400751494
Language : En, Es, Fr & De

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Book Description :

Advances in the biomedical sciences, especially genomics, proteomics, and metabolomics, taken together with the expanding use of electronic health records, are radically changing the IT infrastructure and software applications needed to support the transfer of knowledge from bench to bedside. Pediatric Biomedical Informatics: Computer Applications in Pediatric Research describes the core resources in informatics necessary to support biomedical research programs and how these can best be integrated with hospital systems to receive clinical information that is necessary to conduct translational research.The focus is on the authors’ recent practical experiences in establishing an informatics infrastructure in a large research-intensive children’s hospital. This book is intended for translational researchers and informaticians in pediatrics, but can also serve as a guide to all institutions facing the challenges of developing and strengthening informatics support for biomedical research. The first section of the book discusses important technical challenges underlying computer-based pediatric research, while subsequent sections discuss informatics applications that support biobanking and a broad range of research programs. Pediatric Biomedical Informatics provides practical insights into the design, implementation, and utilization of informatics infrastructures to optimize care and research to benefit children. Dr. John Hutton is the Vice President and Director of Biomedical Informatics at Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA. He is also Professor of Pediatrics and Associate Dean for Information Services at the University of Cincinnati College of Medicine.

Pediatric Biomedical Informatics

Pediatric Biomedical Informatics Book
Author : John J. Hutton
Publisher : Springer
Release : 2015-01-29
ISBN : 9789401782203
Language : En, Es, Fr & De

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Book Description :

Advances in the biomedical sciences, especially genomics, proteomics, and metabolomics, taken together with the expanding use of electronic health records, are radically changing the IT infrastructure and software applications needed to support the transfer of knowledge from bench to bedside. Pediatric Biomedical Informatics: Computer Applications in Pediatric Research describes the core resources in informatics necessary to support biomedical research programs and how these can best be integrated with hospital systems to receive clinical information that is necessary to conduct translational research.The focus is on the authors’ recent practical experiences in establishing an informatics infrastructure in a large research-intensive children’s hospital. This book is intended for translational researchers and informaticians in pediatrics, but can also serve as a guide to all institutions facing the challenges of developing and strengthening informatics support for biomedical research. The first section of the book discusses important technical challenges underlying computer-based pediatric research, while subsequent sections discuss informatics applications that support biobanking and a broad range of research programs. Pediatric Biomedical Informatics provides practical insights into the design, implementation, and utilization of informatics infrastructures to optimize care and research to benefit children. Dr. John Hutton is the Vice President and Director of Biomedical Informatics at Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA. He is also Professor of Pediatrics and Associate Dean for Information Services at the University of Cincinnati College of Medicine.

Volatile Organic Compound Analysis in Biomedical Diagnosis Applications

Volatile Organic Compound Analysis in Biomedical Diagnosis Applications Book
Author : Raquel Cumeras,Xavier Correig
Publisher : CRC Press
Release : 2018-11-22
ISBN : 042978242X
Language : En, Es, Fr & De

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Book Description :

This volume presents a thought-provoking state-of-the-art picture of how volatile compounds are used in metabolomics, currently a hot topic in the metabolomics field. It provides a thorough description of what volatile organic compounds (VOCs) are, why they are important in biomedicine, and what the analytical platforms are used. It also looks at multivariate analysis and databases needs. Because VOCs are end-up compounds of metabolic processes, volatiles can be linked to different diseases or pathologies for both diagnosis and prognosis. The authors provide authoritative information and guidance on the analytical and statistical techniques used and how to identify, and they review the main current areas of application, which include breath metabolomics, cancer diagnosis, and microbial volatiles. Key Features: Presents a thorough overview of volatile research in biomedical applications Examines both gold standard techniques (metabolomics based) and artificial olfactory systems Reviews all aspects of volatile metabolites in biomedicine research, from origin to detection platforms Describes relevant diseases diagnosis and prognosis achievements, including cancer

Toward Precision Medicine

Toward Precision Medicine Book
Author : National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on A Framework for Developing a New Taxonomy of Disease
Publisher : National Academies Press
Release : 2012-01-16
ISBN : 0309222222
Language : En, Es, Fr & De

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Book Description :

Motivated by the explosion of molecular data on humans-particularly data associated with individual patients-and the sense that there are large, as-yet-untapped opportunities to use this data to improve health outcomes, Toward Precision Medicine explores the feasibility and need for "a new taxonomy of human disease based on molecular biology" and develops a potential framework for creating one. The book says that a new data network that integrates emerging research on the molecular makeup of diseases with clinical data on individual patients could drive the development of a more accurate classification of diseases and ultimately enhance diagnosis and treatment. The "new taxonomy" that emerges would define diseases by their underlying molecular causes and other factors in addition to their traditional physical signs and symptoms. The book adds that the new data network could also improve biomedical research by enabling scientists to access patients' information during treatment while still protecting their rights. This would allow the marriage of molecular research and clinical data at the point of care, as opposed to research information continuing to reside primarily in academia. Toward Precision Medicine notes that moving toward individualized medicine requires that researchers and health care providers have access to very large sets of health- and disease-related data linked to individual patients. These data are also critical for developing the information commons, the knowledge network of disease, and ultimately the new taxonomy.

OMICS

OMICS Book
Author : Debmalya Barh,Kenneth Blum,Margaret A. Madigan
Publisher : CRC Press
Release : 2016-04-19
ISBN : 1439850097
Language : En, Es, Fr & De

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Book Description :

A reflection of the explosion of research and development in this field, OMICS: Biomedical Perspectives and Applications explores applications of omics in bioinformatics, cancer research and therapy, diabetes research, plant science, molecular biology, and neurosciences. A select editorial panel of experts discusses their cutting edge omics research and novel technologies, supplying a basic platform of methods and applications and a resource for enhanced cross-pollination in a multiomics approach to future endeavors in the fertile fields of omics research. After an introduction on the omics universe, the book presents modern omics and its applications in nanotechnology, genomics, proteomics, metagenomics, toxicogenomics, immunomics, nutrigenomics, diabetes, neurology, cardiology, and cancer to name just a few. The book begins with an overview of omics and omic technologies such as cellomics, glycomics, and lipidomics. It also discusses bioinformatics, demonstrating how it can be a tool in omics, and examines the various approaches of omics technology in toxicology research and applications in biomedical sciences. While there are a long list of omics books available, most focus narrowly on one area. Presenting a wide view of the current status of integrative omics, this resource contains complete coverage of omics in research and therapy, ranging from neuroscience to cardiology. It collates recent developments in the field into a state-of-the-art framework for this discipline.

Genetics Meets Metabolomics

Genetics Meets Metabolomics Book
Author : Karsten Suhre
Publisher : Springer Science & Business Media
Release : 2012-06-15
ISBN : 1461416892
Language : En, Es, Fr & De

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Book Description :

This book is written by leading researchers in the fields about the intersection of genetics and metabolomics which can lead to more comprehensive studies of inborn variation of metabolism.

Metabolomic responses to Recombinant Human Erythropoietin administration

Metabolomic responses to Recombinant Human Erythropoietin administration Book
Author : Tushar Chatterji
Publisher : GRIN Verlag
Release : 2012-02-22
ISBN : 3656137838
Language : En, Es, Fr & De

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Book Description :

Master's Thesis from the year 2011 in the subject Medicine - Biomedical Engineering, grade: B2,Merit, University of Glasgow (Cardiovascular and Medical Sciences), course: Master's of Research Biomedical Sciences, language: English, abstract: Metabolomics is the comprehensive analysis of the metabolite profiles within a biological system. r-HuEPO stimulates red blood cell production, thereby enhancing maximal oxygen delivery to the tissues. The ergogenic potential of r-HuEPO, demonstrated through improved aerobic capacity and performance has reported r-HuEPO to be the most widely abused erythropoietic stimulant till date. This study was aimed at determining the effects of r-HuEPO on the human metabolome by analyzing metabolites from blood plasma and urine. Analysis of these metabolites was then used to determine how such metabolic interactions affected physiological status and exercise performance. Three well trained individuals participated in the study. Blood and urine were collected from the subjects. Plasma and urine samples were analyzed for metabolites by LC-MS Orbitrap and data was analyzed in the form of heatmaps and PCA plots. Further data interpretations for metabolites of interest were performed by a software, mzMatch/PeakML. Analysis of the human metabolome revealed 1000 metabolites which were manually categorized into 190 human metabolites. Significant metabolite patterns in response to r-HuEPO suggested the physiological effects of r-HuEPO on certain metabolites. A better understanding of the metabolic changes mediated by r-HuEPO might provide an insight into the metabolic signals in response to exercise performance.

Knowledge Based Bioinformatics

Knowledge Based Bioinformatics Book
Author : Gil Alterovitz,Marco Ramoni
Publisher : John Wiley & Sons
Release : 2011-04-20
ISBN : 9781119995838
Language : En, Es, Fr & De

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Book Description :

There is an increasing need throughout the biomedical sciences for a greater understanding of knowledge-based systems and their application to genomic and proteomic research. This book discusses knowledge-based and statistical approaches, along with applications in bioinformatics and systems biology. The text emphasizes the integration of different methods for analysing and interpreting biomedical data. This, in turn, can lead to breakthrough biomolecular discoveries, with applications in personalized medicine. Key Features: Explores the fundamentals and applications of knowledge-based and statistical approaches in bioinformatics and systems biology. Helps readers to interpret genomic, proteomic, and metabolomic data in understanding complex biological molecules and their interactions. Provides useful guidance on dealing with large datasets in knowledge bases, a common issue in bioinformatics. Written by leading international experts in this field. Students, researchers, and industry professionals with a background in biomedical sciences, mathematics, statistics, or computer science will benefit from this book. It will also be useful for readers worldwide who want to master the application of bioinformatics to real-world situations and understand biological problems that motivate algorithms.

Advances in Gas Chromatography

Advances in Gas Chromatography Book
Author : Xinghua Guo
Publisher : BoD – Books on Demand
Release : 2014-02-26
ISBN : 9535112279
Language : En, Es, Fr & De

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Book Description :

For decades gas chromatography has been and will remain an irreplaceable analytical technique in many research areas for both quantitative analysis and qualitative characterization/identification, which is still supplementary with HPLC. This book highlights a few areas where significant advances have been reported recently and/or a revisit of basic concepts is deserved. It provides an overview of instrumental developments, frontline and modern research as well as practical industrial applications. The topics include GC-based metabolomics in biomedical, plant and microbial research, natural products as well as characterization of aging of synthetic materials and industrial monitoring, which are contributions of several experts from different disciplines. It also contains best hand-on practices of sample preparation (derivatization) and data processing in daily research. This book is recommended to both basic and experienced researchers in gas chromatography.

International Research Centers Directory

International Research Centers Directory Book
Author : Anonim
Publisher : Unknown
Release : 2009
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

"A world guide to government, university, independent nonprofit, and commercial research and development centers, institutes, laboratories, bureaus, test facilities, experiment stations, and data collection and analysis centers, as well as foundations, councils and other organizations which support research," [1992/93-].

Single Cell Sequencing and Systems Immunology

Single Cell Sequencing and Systems Immunology Book
Author : Xiangdong Wang
Publisher : Springer
Release : 2015-03-27
ISBN : 9401797536
Language : En, Es, Fr & De

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Book Description :

The volume focuses on the genomics, proteomics, metabolomics, and bioinformatics of a single cell, especially lymphocytes and on understanding the molecular mechanisms of systems immunology. Based on the author’s personal experience, it provides revealing insights into the potential applications, significance, workflow, comparison, future perspectives and challenges of single-cell sequencing for identifying and developing disease-specific biomarkers in order to understand the biological function, activation and dysfunction of single cells and lymphocytes and to explore their functional roles and responses to therapies. It also provides detailed information on individual subgroups of lymphocytes, including cell characters, function, surface markers, receptor function, intracellular signals and pathways, production of inflammatory mediators, nuclear receptors and factors, omics, sequencing, disease-specific biomarkers, bioinformatics, networks and dynamic networks, their role in disease and future prospects. Dr. Xiangdong Wang is a Professor of Medicine, Director of Shanghai Institute of Clinical Bioinformatics, Director of Fudan University Center for Clinical Bioinformatics, Director of the Biomedical Research Center of Zhongshan Hospital, Deputy Director of Shanghai Respiratory Research Institute, Shanghai, China.

Design and Synthesis of Advanced Materials for Separation Science

Design and Synthesis of Advanced Materials for Separation Science Book
Author : Michael Douglas Slater
Publisher : Unknown
Release : 2009
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Design and Synthesis of Advanced Materials for Separation Science book written by Michael Douglas Slater, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

New Scientist

New Scientist Book
Author : Anonim
Publisher : Unknown
Release : 2009
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download New Scientist book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.