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Metabolomics And Microbiomics

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Metabolomics and Microbiomics

Metabolomics and Microbiomics Book
Author : Vassilios Fanos
Publisher : Academic Press
Release : 2016-08-30
ISBN : 0128054506
Language : En, Es, Fr & De

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Book Description :

Metabolomics and Microbiomics: Personalized Medicine from the Fetus to the Adult encompasses the most recent advances on the usage of metabolomics and microbiome research to improve disease diagnosis and healthcare. Medicine is changing from epidemiologic, descriptive, reductionist, and reactive approaches to individualized, predictive, and holistic ones by applying microbiomics to understand the functionality of the human body. The book discusses topics such as systems biology approaches, omics technologies, perinatal programming, and personalized medicine. It also discusses the ethical implications of microbiomics research and new pathways of research, such as renal regenerative medicine, gender medicine in perinatology, and animals and the science of healing. The book is a valuable resource for medical professionals and researchers in metabolomics, nutrition, microbiology, and personalized-predictive medicine. The book also will appeal to non-specialized professionals who may take advantage of its captivating and simple language. Covers the latest scientific discoveries in order to improve health and early diagnosis of diseases Brings a holistic and perinatal programming approach—from fetus to adulthood—to early and long-term prevention of diseases Provides illustrations and diagrams to facilitate understanding for readers Discusses the ethical implications of microbiomics research and new pathways of research, such as renal regenerative medicine, gender medicine in perinatology, and animals and the science of healing

Translational Systems Medicine and Oral Disease

Translational Systems Medicine and Oral Disease Book
Author : Stephen Sonis,Alessandro Villa
Publisher : Academic Press
Release : 2019-09-14
ISBN : 0128137630
Language : En, Es, Fr & De

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Book Description :

Translational Systems Medicine and Oral Disease bridges the gap between discovery science and clinical oral medicine, providing opportunities for both the scientific and clinical communities to understand how to apply recent findings in cell biology, genomic profiling, and systems medicine to favorably impact the diagnosis, treatment and management of oral diseases. Fully illustrated chapters from leading international contributors explore clinical applications of genomics, proteomics, metabolomics, microbiomics and epigenetics, as well as analytic methods and functional omics in oral medicine. Disease specific chapters detail systems approaches to periodontal disease, salivary gland diseases, oral cancer, bone disease, and autoimmune disease, among others. In addition, the book emphasizes biological synergisms across disciplines and their translational impact for clinicians, researchers and students in the fields of dentistry, dermatology, gastroenterology, otolaryngology, oncology and primary care. Presents the work of leading international researchers and clinicians who speak on the clinical applications of genomics, proteomics, metabolomics, microbiomics, and epigenetics, as well as analytic methods and functional omics in oral medicine Provides full-color, richly illustrated chapters that examine systems approaches to periodontal disease, salivary gland diseases, oral cancer, bone disease and autoimmune diseases Includes clinical case studies that illustrate examples of oral disease diagnostics and management, highlighting points of key importance for the reader Emphasizes biological synergisms across disciplines and their translational impact for clinicians, researchers, and students in the fields of dentistry, dermatology, gastroenterology, otolaryngology, oncology, and primary care

The Human Microbiome Diet and Health

The Human Microbiome  Diet  and Health Book
Author : Institute of Medicine,Food and Nutrition Board,Food Forum
Publisher : National Academies Press
Release : 2013-03-13
ISBN : 0309265851
Language : En, Es, Fr & De

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Book Description :

The Food Forum convened a public workshop on February 22-23, 2012, to explore current and emerging knowledge of the human microbiome, its role in human health, its interaction with the diet, and the translation of new research findings into tools and products that improve the nutritional quality of the food supply. The Human Microbiome, Diet, and Health: Workshop Summary summarizes the presentations and discussions that took place during the workshop. Over the two day workshop, several themes covered included: The microbiome is integral to human physiology, health, and disease. The microbiome is arguably the most intimate connection that humans have with their external environment, mostly through diet. Given the emerging nature of research on the microbiome, some important methodology issues might still have to be resolved with respect to undersampling and a lack of causal and mechanistic studies. Dietary interventions intended to have an impact on host biology via their impact on the microbiome are being developed, and the market for these products is seeing tremendous success. However, the current regulatory framework poses challenges to industry interest and investment.

Statistical Analysis of Microbiome Data

Statistical Analysis of Microbiome Data Book
Author : Somnath Datta,Subharup Guha
Publisher : Springer Nature
Release : 2021-10-27
ISBN : 3030733513
Language : En, Es, Fr & De

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Book Description :

Microbiome research has focused on microorganisms that live within the human body and their effects on health. During the last few years, the quantification of microbiome composition in different environments has been facilitated by the advent of high throughput sequencing technologies. The statistical challenges include computational difficulties due to the high volume of data; normalization and quantification of metabolic abundances, relative taxa and bacterial genes; high-dimensionality; multivariate analysis; the inherently compositional nature of the data; and the proper utilization of complementary phylogenetic information. This has resulted in an explosion of statistical approaches aimed at tackling the unique opportunities and challenges presented by microbiome data. This book provides a comprehensive overview of the state of the art in statistical and informatics technologies for microbiome research. In addition to reviewing demonstrably successful cutting-edge methods, particular emphasis is placed on examples in R that rely on available statistical packages for microbiome data. With its wide-ranging approach, the book benefits not only trained statisticians in academia and industry involved in microbiome research, but also other scientists working in microbiomics and in related fields.

Metabolic Profiling

Metabolic Profiling Book
Author : Georgios A. Theodoridis,Helen G. Gika,Ian D. Wilson
Publisher : Humana
Release : 2019-04-30
ISBN : 9781493992522
Language : En, Es, Fr & De

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Book Description :

This volume explores the different approaches and techniques used by researchers to study the recent challenges and developments in metabolic profiling. This book is divided into IV parts. Part I contains chapters that highlight basic concepts, such as experimental design, data treatment, metabolite identification, and harmonization. Part II describes experimental protocols for both targeted and untargeted metabolomics covering the basic analytical technologies: LC-MS, GC-MS, NMR and CE-MS. In addition the protocols describe methods for the study of tissues, feces, blood and other types of biological samples as well as the application of chemical derivatization for GC-MS. Parts III and IV present the use of metabolomics in the study of food, plants and the life sciences, with examples from the quest for the discovery of disease biomarkers, physical exercise omics and metabolic profiling of food, fruit and wine. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and thorough, Metabolic Profiling: Methods and Protocols is a valuable resource for researchers who are interested in expanding their knowledge of this rapidly developing field.

Comprehensive Natural Products III

Comprehensive Natural Products III Book
Author : Anonim
Publisher : Elsevier
Release : 2020-07-22
ISBN : 0081026919
Language : En, Es, Fr & De

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Book Description :

Comprehensive Natural Products III, Third Edition, updates and complements the previous two editions, including recent advances in cofactor chemistry, structural diversity of natural products and secondary metabolites, enzymes and enzyme mechanisms and new bioinformatics tools. Natural products research is a dynamic discipline at the intersection of chemistry and biology concerned with isolation, identification, structure elucidation, and chemical characteristics of naturally occurring compounds such as pheromones, carbohydrates, nucleic acids and enzymes. This book reviews the accumulated efforts of chemical and biological research to understand living organisms and their distinctive effects on health and medicine and to stimulate new ideas among the established natural products community. Provides readers with an in-depth review of current natural products research and a critical insight into the future direction of the field Bridges the gap in knowledge by covering developments in the field since the second edition published in 2010 Split into 7 sections on key topics to allow students, researchers and professionals to find relevant information quickly and easily Ensures that the knowledge within is easily understood by and applicable to a large audience

Precision Medicine for Investigators Practitioners and Providers

Precision Medicine for Investigators  Practitioners and Providers Book
Author : Joel Faintuch,Salomao Faintuch
Publisher : Academic Press
Release : 2019-11-16
ISBN : 0128191791
Language : En, Es, Fr & De

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Book Description :

Precision Medicine for Investigators, Practitioners and Providers addresses the needs of investigators by covering the topic as an umbrella concept, from new drug trials to wearable diagnostic devices, and from pediatrics to psychiatry in a manner that is up-to-date and authoritative. Sections include broad coverage of concerning disease groups and ancillary information about techniques, resources and consequences. Moreover, each chapter follows a structured blueprint, so that multiple, essential items are not overlooked. Instead of simply concentrating on a limited number of extensive and pedantic coverages, scholarly diagrams are also included. Provides a three-pronged approach to precision medicine that is focused on investigators, practitioners and healthcare providers Covers disease groups and ancillary information about techniques, resources and consequences Follows a structured blueprint, ensuring essential chapters items are not overlooked

Metagenomic Systems Biology

Metagenomic Systems Biology Book
Author : Shailza Singh
Publisher : Springer
Release : 2021-12-22
ISBN : 9789811585647
Language : En, Es, Fr & De

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Book Description :

Download Metagenomic Systems Biology book written by Shailza Singh, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Metabolomics From Fundamentals to Clinical Applications

Metabolomics  From Fundamentals to Clinical Applications Book
Author : Alessandra Sussulini
Publisher : Springer
Release : 2017-01-28
ISBN : 3319476564
Language : En, Es, Fr & De

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Book Description :

This book provides a comprehensive view of metabolomics, from the basic concepts, through sample preparation and analytical methodologies, to data interpretation and applications in medicine. It is the first volume to cover metabolomics clinical applications while also emphasizing analytical and statistical features. Moreover, future trends and perspectives in clinical metabolomics are also presented. For researches already experienced in metabolomics, the book will be useful as an updated definitive reference. For beginners in the field and graduate students, the book will provide detailed information about concepts and experimental aspects in metabolomics, as well as examples and perspectives of applications of this strategy to clinical questions.

Genomics Proteomics and Metabolomics

Genomics  Proteomics  and Metabolomics Book
Author : Babak Arjmand
Publisher : Springer Nature
Release : 2019-11-14
ISBN : 3030277275
Language : En, Es, Fr & De

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Book Description :

This book provides thorough coverage of high-throughput OMICs technologies for the monitoring of stem cells and regenerative medicine. Specific topics covered include the genomics, proteomics, and metabolomics aspects of regenerative medicine, metabolic profiling of mesenchymal stem cells, genome profiling of mesenchymal stem cells, OMICs monitoring of stem cell-derived exosomes, stem cell proteomics, lipidomics, OMICs profiling of cancer (stem) cells, and finally ethical considerations of OMICs-based investigations. Chapters are authored by world-renowned scientists who have valuable expertise in the field of OMICs and regenerative medicine. Genomics, Proteomics, and Metabolomics: Stem Cells Monitoring in Regenerative Medicine, part of Springer’s Stem Cell Biology and Regenerative Medicine series, is essential reading for researchers, clinicians, biologists, biochemists, and pharmaceutical experts conducting research in the fields of stem cell biology, molecular aspects of stem cell research, tissue engineering, regenerative medicine, cellular therapy, OMICs, bioinformatics, and ethics.

Comprehensive Foodomics

Comprehensive Foodomics Book
Author : Anonim
Publisher : Elsevier
Release : 2020-11-12
ISBN : 0128163968
Language : En, Es, Fr & De

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Book Description :

Comprehensive Foodomics offers a definitive collection of over 150 articles that provide researchers with innovative answers to crucial questions relating to food quality, safety and its vital and complex links to our health. Topics covered include transcriptomics, proteomics, metabolomics, genomics, green foodomics, epigenetics and noncoding RNA, food safety, food bioactivity and health, food quality and traceability, data treatment and systems biology. Logically structured into 10 focused sections, each article is authored by world leading scientists who cover the whole breadth of Omics and related technologies, including the latest advances and applications. By bringing all this information together in an easily navigable reference, food scientists and nutritionists in both academia and industry will find it the perfect, modern day compendium for frequent reference. List of sections and Section Editors: Genomics - Olivia McAuliffe, Dept of Food Biosciences, Moorepark, Fermoy, Co. Cork, Ireland Epigenetics & Noncoding RNA - Juan Cui, Department of Computer Science & Engineering, University of Nebraska-Lincoln, Lincoln, NE Transcriptomics - Robert Henry, Queensland Alliance for Agriculture and Food Innovation, The University of Queensland, St Lucia, Australia Proteomics - Jens Brockmeyer, Institute of Biochemistry and Technical Biochemistry, University Stuttgart, Germany Metabolomics - Philippe Schmitt-Kopplin, Research Unit Analytical BioGeoChemistry, Neuherberg, Germany Omics data treatment, System Biology and Foodomics - Carlos Leon Canseco, Visiting Professor, Biomedical Engineering, Universidad Carlos III de Madrid Green Foodomics - Elena Ibanez, Foodomics Lab, CIAL, CSIC, Madrid, Spain Food safety and Foodomics - Djuro Josić, Professor Medicine (Research) Warren Alpert Medical School, Brown University, Providence, RI, USA & Sandra Kraljević Pavelić, University of Rijeka, Department of Biotechnology, Rijeka, Croatia Food Quality, Traceability and Foodomics - Daniel Cozzolino, Centre for Nutrition and Food Sciences, The University of Queensland, Queensland, Australia Food Bioactivity, Health and Foodomics - Miguel Herrero, Department of Bioactivity and Food Analysis, Foodomics Lab, CIAL, CSIC, Madrid, Spain Brings all relevant foodomics information together in one place, offering readers a ‘one-stop,’ comprehensive resource for access to a wealth of information Includes articles written by academics and practitioners from various fields and regions Provides an ideal resource for students, researchers and professionals who need to find relevant information quickly and easily Includes content from high quality authors from across the globe

Microbiome and Metabolome in Diagnosis Therapy and other Strategic Applications

Microbiome and Metabolome in Diagnosis  Therapy  and other Strategic Applications Book
Author : Joel Faintuch,Salomao Faintuch
Publisher : Academic Press
Release : 2019-01-03
ISBN : 0128152508
Language : En, Es, Fr & De

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Book Description :

Microbiome and Metabolome in Diagnosis, Therapy, and Other Strategic Applications is the first book to simultaneously cover the microbiome and the metabolome in relevant clinical conditions. In a pioneering fashion, it addresses not only the classic intestinal environment, but also the oral, gastric, lung, skin and vaginal microbiome that is in line with the latest investigations. Nonbacterial microbiomes, such as fungi and viruses are not overlooked, and the plasma microbiome is also discussed. As plasma, brain, placenta, tumor cells, and other sterile fluids and tissues, are increasingly recognized to potentially host a microbiome, albeit a limited one, this is a timely resource. The book's editors were fortunate to have the input of renowned collaborators from nearly all continents. This is truly an international effort that brings the latest in the field to students and professionals alike. Provides comprehensive coverage on diagnosis, therapy, pharmacotherapy and disease prevention in context of the microbiome and metabolome Focuses on the proposed physiological or pathological conditions Presents an up-to-date, useful reference

The OMICs

The OMICs Book
Author : Giovanni Coppola
Publisher : Oxford University Press
Release : 2014
ISBN : 0199855455
Language : En, Es, Fr & De

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Book Description :

The OMICs:Applications in Neuroscience summarizes the state of the art in OMICs applications in neurology and neuroscience, attracting neurologists who are interested in the progress of this field towards clinical applications, and neuroscientists who may be not familiar with the most recent advances in this ever-changing field. The book will include an overview of most relevant high-throughput approaches (collectively known as 'OMICs') and how they relate to neurology and neuroscience. The explosion of high-throughput assays has introduced large datasets, computational servers, and bioinformatics approaches to neuroscience and medicine in general. The reader will be provided with an overview of the application or method, a perspective on the current and future applications in neurology and neuroscience, and a few published examples illustrating possible practical use. Emerging topics such as ethical issues related to personal genome sequencing, epigenetics, network analysis, and role of peripheral biomarkers in disease diagnosis and follow-up will be covered as well.

Microbial Metabolomics

Microbial Metabolomics Book
Author : David J. Beale,Konstantinos A. Kouremenos,Enzo A. Palombo
Publisher : Springer
Release : 2016-12-05
ISBN : 3319463268
Language : En, Es, Fr & De

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Book Description :

This book brings together contributions from global experts who have helped to facilitate the exciting and rapid advances that are taking place in microbial metabolomics. The main application of this field is in clinical and veterinary microbiology, but there is a great potential to apply metabolomics to help to better understand complex biological systems that are dominated by multiple-species microbial populations exposed to changing growth and nutritional conditions. In particular, environmental (e.g., water, soil), food (e.g., microbial spoilage, food pathogens), and agricultural and industrial applications are seen as developing areas for microbial metabolomics. As such, the book includes contributions with clinical, environmental, and industrial perspectives.

Metabolic Interaction in Infection

Metabolic Interaction in Infection Book
Author : Ricardo Silvestre,Egídio Torrado
Publisher : Springer
Release : 2018-04-06
ISBN : 3319749323
Language : En, Es, Fr & De

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Book Description :

This book focuses on host–pathogen interactions at the metabolic level. It explores the metabolic requirements of the infectious agents, the microbial metabolic pathways that are dedicated to circumvent host immune mechanisms as well as the molecular mechanisms by which pathogens hijack host cell metabolism for their own benefit. Finally, it provides insights on the possible clinical and immunotherapeutic applications, as well as on the available experimental and analytical methods. The contributions break new ground in understanding the metabolic crosstalk between host and pathogen.

Cruciferous Vegetables Isothiocyanates and Indoles

Cruciferous Vegetables  Isothiocyanates and Indoles Book
Author : International Agency for Research on Cancer,IARC Working Group on the Evaluation of Cancer-Preventive Strategies,World Health Organization
Publisher : IARC
Release : 2004
ISBN : 9789283230090
Language : En, Es, Fr & De

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Book Description :

This publication sets outs the findings of an IARC Working Group, held in Lyon, France in November 2003, which considered the benefits of a diet rich in cruciferous vegetables in helping to reduce the risk of various cancers. Cruciferous vegetables, such as broccoli, cabbage, cauliflower, watercress and brussel sprouts, contain substantial amounts of compounds which have been shown to inhibit the growth of cancers. This publication reviews current knowledge on the topic, including data from human, experimental and mechanistic studies, as well as making recommendations for future research and public health policy options.

The Handbook of Metabolic Phenotyping

The Handbook of Metabolic Phenotyping Book
Author : John C. Lindon,Jeremy K. Nicholson,Elaine Holmes
Publisher : Elsevier
Release : 2018-09-25
ISBN : 9780128122938
Language : En, Es, Fr & De

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Book Description :

The Handbook of Metabolic Phenotyping is the definitive work on the rapidly developing subject of metabolic phenotyping. It explores the wide array of analytical chemistry and statistical modelling techniques used in the field, also presenting surveys of various application areas in human development, nutrition, disease, therapy and epidemiology. The book covers recent studies that integrate the various -omics datasets to derive a system biology view. It also addresses current issues on standardization, assay and statistics validation, and data storage and sharing. Written by experts, the book is a valuable resource for post-grads and research scientists studying and furthering the field of metabolomics. Contains theoretical and practical explanations of all the main analytical chemistry techniques used in metabolic phenotyping Explores, in detail, the many diverse statistical approaches used in the field Offers practical tips for successfully conducting metabolic phenotyping studies Features reviews of all of the various fields of activity relating to human studies

Food Allergy An Issue of Immunology and Allergy Clinics of North America

Food Allergy  An Issue of Immunology and Allergy Clinics of North America Book
Author : Amal Assa’Ad
Publisher : Elsevier Health Sciences
Release : 2021-04-22
ISBN : 0323813208
Language : En, Es, Fr & De

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Book Description :

This issue of Immunology & Allergy Clinics, guested edited by Dr. Amal Assa’ad, focuses on Food Allergy. Topics include, but are not limited to: Food Allergy: An example of translational Research, The Phenotype of the Food Allergic Patient, Psychosocial aspects of food allergy: Resiliency, challenges and opportunities, Racial/Ethnic Differences in Food Allergy, Tackling Food Allergy in Infancy, Developing National and International guidelines, Dietary Management of Food Allergy, Biologics and Novel Therapies for Food Allergy, The Infant Microbiome and Its Impact on Development of Food Allergy, Genetics of Food Allergy, The Unmet Needs of Patients with Food Allergies, Food Allergy, the Present and the Future, and more.

Innovative Technologies and Signal Processing in Perinatal Medicine

Innovative Technologies and Signal Processing in Perinatal Medicine Book
Author : Danilo Pani,Chiara Rabotti,Maria Gabriella Signorini,Laura Burattini
Publisher : Springer Nature
Release : 2020-10-20
ISBN : 3030544036
Language : En, Es, Fr & De

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Book Description :

Pregnancy is a critical time for the health of the mother and the fetus, with important potential risks for both. Tools for antenatal diagnosis and pregnancy monitoring can support prevention and management of potential risks and complications. In particular, the perinatal period, spanning from the third trimester of pregnancy up to one month after birth, is the most critical for the baby. For this reason, in the last decades, biomedical engineering supported and fostered the scientific research towards the identification of new models, parameters, algorithms, and tools that can improve the quality of fetal monitoring, predict the outcomes and allow physicians to intervene in an appropriate manner to ensure a healthy future for the baby. This book follows the First International Summer School on Technologies and Signal Processing in Perinatal Medicine and reflects some of its most important master lectures. It represents a valuable guide for students and young researchers approaching this topic for the first time, as well as experienced researchers and practitioners looking for a clear representation of the themes and techniques presented by recognized experts in the field. Presents current and innovative technologies for fetal and neonatal monitoring Emphasis on both technology/signal processing and clinical aspects Offers a clear didactic approach to the subject matter

Obesity and Diabetes

Obesity and Diabetes Book
Author : Joel Faintuch,Salomão Faintuch
Publisher : Springer Nature
Release : 2020-12-14
ISBN : 3030533700
Language : En, Es, Fr & De

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Book Description :

Now in its second edition, this comprehensive handbook provides a state-of-the-art overview of recent advances in drug and non-drug therapies for obesity and diabetes. It also addresses major comorbidities, covering topics such as, cardiovascular diseases, renal and neuropsychiatric disorders, appetite control and micro RNAs. Special attention is also devoted to pediatric care, including the latest recommendations for therapy and prevention. Obesity and type 2 diabetes are among the top global health-care budget concerns worldwide and impact professional practice at all levels: in hospitals, clinics and physicians’ offices alike. They prominently feature in headlines, and virtually no family, community or country is exempt from their protean, deleterious consequences. Furthermore, given the multiple intersections in their pathways, they often go hand in hand. The good news is that scientific advances in all fields, including genomics, metabolomics, lipidomics and microbiomics, are increasing our understanding of these two disease areas. At the same time, artificial intelligence, machine learning, mobile health and advanced implantable and external devices are rendering prevention and management more available, safe and cost-effective. In addition, bariatric and metabolic surgery has evolved from a niche specialty to an officially endorsed option for several modalities of obesity and diabetes. This book presents the latest lifestyle, pharmacological, surgical and non-surgical treatment options, including endoscopic intervention and cell therapy. Objectively reviewing natural and artificial sweeteners and critically examining issues such as public health initiatives, government mandated taxes for unhealthy foods and environmental planning, no stone is left unturned in gathering the latest practical information. As such, the book will appeal to seasoned specialists, as well as students and healthcare professionals in training.