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Mesenchymal Stromal Cells As Tumor Stromal Modulators

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Mesenchymal Stromal Cells as Tumor Stromal Modulators

Mesenchymal Stromal Cells as Tumor Stromal Modulators Book
Author : Marcela Bolontrade,Mariana García
Publisher : Academic Press
Release : 2016-10-24
ISBN : 0128031034
Language : En, Es, Fr & De

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Book Description :

Mesenchymal stromal/ stem cells (MSCs) represent a heterogeneous cell population with immunomodulating, tissue repairing, differentiating, migratory and angiogenic abilities, making them important tools for clinical and translational research. An understanding of the role of MSCs in modulating tumor growth provides a glimpse into their role in non-pathological tissue remodeling and potential regenerative tissue therapies. Mesenchymal Stromal Cells as Tumor Stromal Modulators is a comprehensive source for the understanding of the role of MSCs as ubiquitous connective tissue cell components, which may have both direct and indirect effects on the tumor microenvironment and potential for regenerative therapeutics for various diseases. Using cancer as a model disease, this book explores the transformative role MSCs play in the recruitment of disease cells, cell repair and immunological defenses. Explores the biology of mesenchymal stromal cells (MSCs) and tissue related function Discusses the bidirectional communication between tumor stroma and MSCs derived from bone marrow, from adipose tissue and from other tissue types Provides in-depth analysis of the effects of MSCs on key processes that regulate disease progression, such as angiogenesis, metastatic potential, invasion, proliferation, tumor immune privileges

Mesenchymal Stromal Cells in Healthy and Melanoma Infiltrated Human Lymph Nodes

Mesenchymal Stromal Cells in Healthy and Melanoma Infiltrated Human Lymph Nodes Book
Author : Jennifer Eom
Publisher : Unknown
Release : 2019
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Mesenchymal stromal cells (MCs) in the tumour micro environment (TME) are receiving increasing interest, as they can support tumourigenesis. The analysis of MCs in lymph node (LN) is important as what happens in this organ may support early tumour metastasis and may regulate generation of anti-tumour immune responses. However, very little is known about the phenotype and function MCs in both healthy LNs and tumour infiltrated LNs, which hinders targeting of these cells in cancer therapy. In this study, we present molecular markers that enable a new level of discrimination between the different subtypes of MCs in healthy LNs. We characterised a population of CD90+ CD34+ cells residing in the capsule, trabeculae and hilum and overall showed a similar phenotypic profile to adult mesenchymal stem/stromal cells (MSCs) identified in other tissues. We showed that we could distinguish pericytes (CD34- podoplanin- CD146+ cells) from other LN MCs. These cells showed interesting dichotomy of NG2 and CD36 expression on arterial versus venous vasculature. This finding is likely to be helpful in distinguishing pericyte populations in other human tissues as well. We next sought to examine melanoma infiltrated LNs (MILNs) surgically resected from patients. We identified CD90+ CD34+ MCs in regions containing dense collagen fibres. These cells expressed FAP and CD26, suggesting they have become activated. CD34- reticular cells showed dim or no expression of immune cell adhesion molecules, ICAM1 and VCAM1. Despite this, we observed tight association of T cells with the stromal network, which suggested that CD34- reticular cells may be preventing T cells from migrating into melanoma nests. These results suggest that both CD90+ CD34+ cells and CD34- reticular cells were altered by infiltrating melanoma cells to acquire different phenotypic and functional properties. We subsequently examined the transcriptome profile of CD90+ CD34+ cells and CD34- reticular cells using microarray. CD90+ CD34+ cells expressed several genes that are part of ECM or related to ECM modulation, as well as genes related to adipogenic, osteogenic and chondrogenic lineages. CD34- reticular cells expressed genes that promote migration of immune cells, as well as number of other genes associated with immune system. Overall, the gene signature of CD90+ CD34+ cells were similar to adult MSCs, and the gene signature of CD34- reticular cells were similar to reticular stromal cells in healthy LNs. CD90+ CD34+ cells also expressed genes associated with chemokine degradation, suggesting that interplay of 2 types of MCs may play key roles in modulating migration of T cells. The revealed markers now offer new ways to further discriminate melanoma-associated MCs. Next, we sought to analyse the function of MCs in vitro. However, the MCs in vitro showed different phenotypic profiles to MCs in tissues and we were not able to observe any functional differences between MCs cultured from healthy LNs and MILNs. These results highlighted the difficulties in establishing in vitro analysis of MCs that properly represents their function in vivo. Collectively, we now have better understanding about the diversity of MCs in both healthy and melanoma LNs. For the first time, we described the presence of CD34+ cells in MILNs and we have divided melanoma-associated MCs into distinct subtypes; CD90+ CD34+ cells producing thick ECM, CD34- reticular cells producing chemokines and CD34- podoplanin- CD146+ pericytes surrounding vasculature. These results will enable deeper analysis of melanoma-associated MCs and aid discovery of new therapeutic targets.

The Biology and Therapeutic Application of Mesenchymal Cells Set

The Biology and Therapeutic Application of Mesenchymal Cells   Set Book
Author : Kerry Atkinson
Publisher : John Wiley & Sons
Release : 2017-01-17
ISBN : 1118907515
Language : En, Es, Fr & De

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Book Description :

The Biology and Therapeutic Application of Mesenchymal Cells comprehensively describes the cellular and molecular biology of mesenchymal stem cells and mesenchymal stromal cells, describing their therapeutic potential in a wide variety of preclinical models of human diseases and their mechanism of action in these preclinical models. Chapters also discuss the current status of the use of mesenchymal stem and stromal cells in clinical trials in a wide range of human diseases and disorders, for many of which there are limited, or no other, therapeutic avenues. • Provides coverage on both the biology of mesenchymal stem cells and stromal cells, and their therapeutic applications • Describes the therapeutic potential of mesenchymal stem and stromal cells in a wide variety of preclinical models of human diseases and their mechanism of action in these preclinical models • Discusses the current status of mesenchymal stem and stromal cells in clinical trials in a wide range of human diseases and disorders, for many of which there are limited, or no other, therapeutic avenues • Written and edited by leaders in the field The Biology and Therapeutic Application of Mesenchymal Cells is an invaluable resource for those studying stem cells, cell biology, genetics, gene or cell therapy, or regenerative medicine. About the Author Kerry Atkinson, MBBS MD DTM&H FRCP FRACP, is an Adjunct Professor at the University of Queensland Centre for Clinical Research in Brisbane, Australia, an Adjunct Professor in the Stem Cell Laboratories, Queensland University of Technology at the Translational Research Institute, Brisbane, Queensland, Australia and a Specialist in Internal Medicine at the Salisbury Medical Centre, Brisbane, Queensland, Australia.

Mesenchymal Stromal Cells MSCs

Mesenchymal Stromal Cells  MSCs  Book
Author : Randy Morrison
Publisher : Unknown
Release : 2017
ISBN : 9781634857208
Language : En, Es, Fr & De

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Book Description :

Mesenchymal stromal cells (MSCs) are considered an important tool in tissue engineering due to their multilineage potential in vitro as in vivo beyond their capacity to produce bioactive molecules involved in tissue regeneration. MSCs are essential elements of the microenvironment because they are the precursors of all stromal cells. MSCs influence HPC functions, such as proliferation, apoptosis, and clonogenic growth, directly via cell-cell contacts or indirectly via the secretion of soluble factors. This book reviews the biology, mechanisms of action and clinical uses of MSCs. Chapter One analyzes the modulation of adhesion molecules on MSCs to help in understanding their possible contribution to cancer initiation and progression. Chapter Two studies adipose derived MSCs in cancer therapy. Chapter Three discusses the improvement of clinical uses of MSCs by 3D scaffold-free constructs. Chapter Four reviews the application of MSCs in veterinary medicine.

Proteoglycans in Stem Cells

Proteoglycans in Stem Cells Book
Author : Martin Götte
Publisher : Springer Nature
Release : 2021-10-21
ISBN : 3030734536
Language : En, Es, Fr & De

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Book Description :

Download Proteoglycans in Stem Cells book written by Martin Götte, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Essentials of Cancer Genomic Computational Approaches and Precision Medicine

 Essentials of Cancer Genomic  Computational Approaches and Precision Medicine Book
Author : Nosheen Masood,Saima Shakil Malik
Publisher : Springer Nature
Release : 2020-03-20
ISBN : 9811510679
Language : En, Es, Fr & De

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Book Description :

This book concisely describes the role of omics in precision medicine for cancer therapies. It outlines our current understanding of cancer genomics, shares insights into the process of oncogenesis, and discusses emerging technologies and clinical applications of cancer genomics in prognosis and precision-medicine treatment strategies. It then elaborates on recent advances concerning transcriptomics and translational genomics in cancer diagnosis, clinical applications, and personalized medicine in oncology. Importantly, it also explains the importance of high-performance analytics, predictive modeling, and system biology in cancer research. Lastly, the book discusses current and potential future applications of pharmacogenomics in clinical cancer therapy and cancer drug development.

Mesenchymal Stem Cells and Immunomodulation

Mesenchymal Stem Cells and Immunomodulation Book
Author : Charles J. Malemud,Eben Alsberg
Publisher : Springer
Release : 2016-12-10
ISBN : 3319467336
Language : En, Es, Fr & De

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Book Description :

This essential volume explores mesenchymal stem cells (MSCs) and their potential to suppress immune-mediated inflammation. The chapters examine applications in autoimmune diseases such as lupus, rheumatoid arthritis and multiple sclerosis; blood cancers such as leukemia and lymphoma; and reproductive complications, specifically pre-term labor and use of MSCs in vitro and in animal models to discover methods of suppressing the causal inflammatory response. It also further defines the methodologies required to develop research on MSCs in vitro into established preclinical animal models including those which are proven replicas of autoimmunity and pre-term labor, to name but two. Mesenchymal Stem Cells and Immunomodulation, part of Springer’s Stem Cell Biology and Regenerative Medicine, is an invaluable resource for researchers and clinicians working with stem cells, autoimmune disease, oncology, and reproductive medicine.

Epidemiology of Brain and Spinal Tumors

Epidemiology of Brain and Spinal Tumors Book
Author : Jahangir Moini,Nicholas Avgeropoulos,Mohtashem Samsam
Publisher : Academic Press
Release : 2021-04-16
ISBN : 0128217553
Language : En, Es, Fr & De

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Book Description :

Epidemiology of Brain and Spinal Tumors provides a single volume resource on imaging methods and neuroepidemiology of both brain and spinal tumors. The book covers a variety of imaging techniques, including computed tomography (CT), MRI, positron emission tomography (PET), and other laboratory tests used in diagnosis and treatment. Detailed epidemiology, various imaging methods, and clinical considerations of tumors of the CNS make this an ideal reference for users who will also find diverse information about structures and functions, cytology, epidemiology (including molecular epidemiology), diagnosis and treatment. This book is appropriate for neuroscience researchers, medical professionals and anyone interested in a complete guide to visualizing and understanding CNS tumors. Provides the most up-to-date information surrounding the epidemiology, biology and imaging techniques for brain and spinal tumors, including CT, MRI, PET, and others Includes full color figures, photos, tables, graphs and radioimaging Contains information that will be valuable to anyone interested in the field of neurooncology and the treatment of patients with brain and spinal tumors Serves as a source of background information for basic scientists and pharmaceutical researchers who have an interest in imaging and treatment

Vertebrate Skeletal Histology and Paleohistology

Vertebrate Skeletal Histology and Paleohistology Book
Author : Vivian de Buffrénil,Armand J. de Ricqlès,Louise Zylberberg,Kevin Padian
Publisher : CRC Press
Release : 2021-06-25
ISBN : 1351189573
Language : En, Es, Fr & De

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Book Description :

Vertebrate Skeletal Histology and Paleohistology summarizes decades of research into the biology and biological meaning of hard tissues, in both living and extinct vertebrates. In addition to outlining anatomical diversity, it provides fundamental phylogenetic and evolutionary contexts for interpretation. An international team of leading authorities review the impact of ontogeny, mechanics, and environment in relation to bone and dental tissues. Synthesizing current advances in the biological problems of growth, metabolism, evolution, ecology, and behavior, this comprehensive and authoritative volume is built upon a foundation of concepts and technology generated over the past fifty years.

Epidemiology of Endocrine Tumors

Epidemiology of Endocrine Tumors Book
Author : Jahangir Moini,Craig Badolato,Raheleh Ahangari
Publisher : Elsevier
Release : 2021-02-17
ISBN : 0128232668
Language : En, Es, Fr & De

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Book Description :

Epidemiology of Endocrine Tumors brings current data and clinical research into one source for a multidisciplinary audience. The book discusses the prevalence, incidence, etiology, pathology, diagnosis and treatment of various endocrine tumors. With clear and focused writing, it is essential reading for healthcare professionals, endocrinologists, oncologists, and public health professionals. Users will be able to bridge the knowledge gap that exists in the comprehensive coverage surrounding the epidemiology of endocrine tumors. Globally, the prevalence and incidence of endocrine tumors is high. This audience needs a treatise where they can gain a broad overview of endocrine tumors with a focus on epidemiology. Supplies information about the epidemiology of various endocrine tumors, both benign and malignant, to endocrinologists, oncologists and related health care professionals Focuses on the impact upon costs and patient deaths due to complications of these tumors Describes how endocrine tumors affect various age groups and ethnicities, discussing the prevention of endocrine tumors Presents chapters on Cancer Problem, Specific Endocrine Tumors, Prevention, Detection and Diagnosis, and Treatment of Endocrine Tumors Provides review questions with an answer key and detailed glossary

Cancer Stem Cells

Cancer Stem Cells Book
Author : Stanley Shostak
Publisher : BoD – Books on Demand
Release : 2011-08-01
ISBN : 9533075805
Language : En, Es, Fr & De

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Book Description :

Over the last thirty years, the foremost inspiration for research on metastasis, cancer recurrence, and increased resistance to chemo- and radiotherapy has been the notion of cancer stem cells.The twenty-eight chapters assembled in Cancer Stem Cells - The Cutting Edge summarize the work of cancer researchers and oncologists at leading universities and hospitals around the world on every aspect of cancer stem cells, from theory and models to specific applications (glioma), from laboratory research on signal pathways to clinical trials of bio-therapies using a host of devices, from solutions to laboratory problems to speculation on cancers' stem cells' evolution. Cancer stem cells may or may not be a subset of slowly dividing cancer cells that both disseminate cancers and defy oncotoxic drugs and radiation directed at rapidly dividing bulk cancer cells, but research on cancer stem cells has paid dividends for cancer prevention, detection, targeted treatment, and improved prognosis.

Update on Mesenchymal and Induced Pluripotent Stem Cells

Update on Mesenchymal and Induced Pluripotent Stem Cells Book
Author : Khalid Ahmed Al-Anazi
Publisher : BoD – Books on Demand
Release : 2020-04-22
ISBN : 1789238072
Language : En, Es, Fr & De

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Book Description :

This book represents an updated overview on selected topics related to mesenchymal stem cells as well as induced pluripotent stem cells. The book is divided into three main sections that cover several topics including: sources of both stem cell types, their preparation and general properties, as well as their therapeutic indications and clinical utilization with particular attention given to their use in infectious diseases, osteoarthritis, as well as immunological disorders.

Cell Biology and Translational Medicine Volume 5

Cell Biology and Translational Medicine  Volume 5 Book
Author : Kursad Turksen
Publisher : Springer
Release : 2019-05-22
ISBN : 3030175898
Language : En, Es, Fr & De

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Book Description :

Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions. This book series 'Cell Biology and Translational Medicine (CBTMED)' as part of SpringerNature’s longstanding and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the fifth volume of a continuing series.

Therapeutic Targeting of Cancer Stem Like Cells CSC The Current State of the Art

Therapeutic Targeting of Cancer Stem Like Cells  CSC      The Current State of the Art Book
Author : Cyril Corbet,Alexandre Prieur
Publisher : Frontiers Media SA
Release : 2020-04-03
ISBN : 288963647X
Language : En, Es, Fr & De

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Book Description :

Download Therapeutic Targeting of Cancer Stem Like Cells CSC The Current State of the Art book written by Cyril Corbet,Alexandre Prieur, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Mesenchymal Stromal Cells

Mesenchymal Stromal Cells Book
Author : Peiman Hematti,Armand Keating
Publisher : Springer Science & Business Media
Release : 2013-01-16
ISBN : 1461457114
Language : En, Es, Fr & De

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Book Description :

Mesenchymal Stromal Cell (MSC) biology has been studied for more than 4 decades and the cells have been investigated for potential clinical applications for more than 15 years. Progress has become exponential over the past decade due mainly to the broad therapeutic potential of these cells. However, MSC studies have also been subject to controversy and increasing scrutiny as new mechanisms of action are reported and ever-expanding therapeutic applications pursued. In this book, leading authorities from all over the world, who are actively involved in this field, provide state-of-the-art knowledge of the basic biology, translational requirements and latest clinical experience with MSCs. This cutting edge book is the ideal resource for scientists and clinicians interested in pursuing an important and rapidly developing field of research that will eventually help patients and address urgent unmet medical needs. Features include: Coverage of the biology of MSCs, latest understanding of mechanisms of action, and role in tissue homeostasis and regeneration Identifying the potential of MSCs in proceeding from bench to bedside from regulatory , GMP production, ethical and safety aspects Critical analysis of clinical studies and the potential of MSCs to treat a wide variety of human diseases and tissues.

Electroporation Based Therapies for Cancer

Electroporation Based Therapies for Cancer Book
Author : Raji Sundararajan
Publisher : Elsevier
Release : 2014-08-28
ISBN : 1908818298
Language : En, Es, Fr & De

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Book Description :

Electroporation-Based Therapies for Cancer reviews electroporation-based clinical studies in hospitals for various cancer treatments, including melanomas, head and neck cancers, chest wall breast carcinomas, and colorectal cancers, as well as research studies in the lab using cell lines, primary cells, and animals. Cancer kills about one American per minute, amounting to over 500,000 deaths in the United States and millions, worldwide, each year. There is a critical need for safe, effective, and affordable alternative treatment modalities, especially for inoperable, recurring, and chemo-resistant cancers, that do not respond well to current treatment regimen. An electrical-pulse-mediated, enhanced drug delivery technique known as electroporation is one way to effectively treat these patients. This technique is especially suitable for low- and middle-income countries, where lack of infrastructure and resources leads to cancer diagnoses at late stages. This quick, safe, effective, economical, out-patient-based technique is a boon to these patients for palliative and other care with enhanced quality of life. This book features discussions by interdisciplinary authors—including practicing oncological surgeons, medical professionals, and academic and other researchers—of the basics and clinical medical applications of electroporation. Provides novel and recent clinical applications of electrochemotherapy for various cancers, including melanomas, sarcomas, superficial extreme melanoma, chest wall breast carcinoma, and colorectal cancers Extensive study of a number of cell lines, including human breast cancer, lung cancer, cervical cancer, leukemia, and mouse breast cancer using both reversible and irreversible electroporation techniques In vitro study of delivery of various commonly prescribed/administered breast cancer chemo and hormone drugs, such as Doxorubicin, Paclitaxel, Bleomycin, and Tamoxifen

Advances in Organ Transplantation Research and Application 2011 Edition

Advances in Organ Transplantation Research and Application  2011 Edition Book
Author : Anonim
Publisher : ScholarlyEditions
Release : 2012-01-09
ISBN : 1464921938
Language : En, Es, Fr & De

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Book Description :

Advances in Organ Transplantation Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Organ Transplantation. The editors have built Advances in Organ Transplantation Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Organ Transplantation in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Organ Transplantation Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Oligomerization and Allosteric Modulation in G Protein Coupled Receptors

Oligomerization and Allosteric Modulation in G Protein Coupled Receptors Book
Author : Anonim
Publisher : Academic Press
Release : 2012-12-02
ISBN : 012394791X
Language : En, Es, Fr & De

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Book Description :

In this thematic volume of Progress in Molecular Biology and Translational Science, researchers reflect on recent developments and research surrounding G protein-coupled receptors. The chapters cover a large breadth of research, including GPCR role in stem cell function and pharmacology. Authors explore in-depth research techniques and applications of GPCR usage, covering theory, laboratory approaches, and unique qualities that make GPCRs a crucial tool in microbiological and cancer research. Contributions from leading authorities Informs and updates on all the latest developments in the field

Stem Cells as Targeted Drug Delivery Vehicles

Stem Cells as Targeted Drug Delivery Vehicles Book
Author : Rebecca Lim,Jessica E. Frith,Gina D. Kusuma,Christopher G. Sobey
Publisher : Frontiers Media SA
Release : 2021-02-03
ISBN : 2889664481
Language : En, Es, Fr & De

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Book Description :

Topic Editor RL is a patent inventor on exosome-related patents, PCT/AU2017/050821 and PCT/AU2016/050468. All other Topic Editors declare no competing interests with regards to the Research Topic subject.

Stem Cells in Regenerative Medicine

Stem Cells in Regenerative Medicine Book
Author : Alain A. Vertes,Nasib Qureshi,Arnold I. Caplan,Lee E. Babiss
Publisher : John Wiley & Sons
Release : 2015-09-14
ISBN : 1118846206
Language : En, Es, Fr & De

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Book Description :

This book is a unique guide to emerging stem cell technologies and the opportunities for their commercialisation. It provides in-depth analyses of the science, business, legal, and financing fundamentals of stem cell technologies, offering a holistic assessment of this emerging and dynamic segment of the field of regenerative medicine. • Reviews the very latest advances in the technology and business of stem cells used for therapy, research, and diagnostics • Identifies key challenges to the commercialisation of stem cell technology and avenues to overcome problems in the pipeline • Written by an expert team with extensive experience in the business, basic and applied science of stem cell research This comprehensive volume is essential reading for researchers in cell biology, biotechnology, regenerative medicine, and tissue engineering, including scientists and professionals, looking to enter commercial biotechnology fields.