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Mesenchymal Stem Cells And Skeletal Regeneration

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Mesenchymal Stem Cells and Skeletal Regeneration

Mesenchymal Stem Cells and Skeletal Regeneration Book
Author : Peter Giannoudis,Elena Jones,Xuebin Yang,Dennis Mcgonagle
Publisher : Academic Press
Release : 2013-02-20
ISBN : 0124081312
Language : En, Es, Fr & De

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Book Description :

This book covers our current understanding of the role of mesenchymal stem cells (MSCs) and other mesenchymal progenitors in skeletal regeneration, encompassing bone, cartilage and whole joint regeneration. The expansion reflects developments in the field to include data on the use of MSCs in drug development, growth factors, scaffolds and biomechanical manipulations for skeletal trauma and diseases, including osteoporosis and arthritis. Written for an audience of clinicians and young researchers who are exposed to MSCs in their work, this work summarizes recent findings pertaining to the definition and characterization of MSCs in skeletal tissues and discusses the mechanisms of their actions in regeneration of bone in vivo. The authors describe recent findings pertaining to the efficacy of MSC therapies in animal models and in human clinical trials and bring together literature showing that the ways MSCs are extracted, expanded and implanted can considerably affect bone formation outcomes. Finally, it presents the latest knowledge on the nature of native MSCs in skeletal tissues, which provide a platform for novel in situ tissue regeneration approaches for systemic bone disease such as osteoporosis. Focuses specifically on the use of stem cells in skeletal tissue generation for a broad audience of stem cell, cancer, and bone biologists, orthopedists, oncologists, and regenerative medicine specialists Provides a short historical ‘detour’ and foundational information on founding concepts, discoveries and personalities in MSC research Assists a new generation of scientists and clinicians in digesting the multitude of journal articles on the topic by providing easily-absorbed and condensed foundational context

Mesenchymal Stem Cells and Skeletal Regeneration

Mesenchymal Stem Cells and Skeletal Regeneration Book
Author : Anonim
Publisher : Unknown
Release : 2013
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This book covers our current understanding of the role of mesenchymal stem cells (MSCs) and other mesenchymal progenitors in skeletal regeneration, encompassing bone, cartilage and whole joint regeneration. The expansion reflects developments in the field to include data on the use of MSCs in drug development, growth factors, scaffolds and biomechanical manipulations for skeletal trauma and diseases, including osteoporosis and arthritis. Written for an audience of clinicians and young researchers who are exposed to MSCs in their work, this work summarizes recent findings pertaining to the definition and characterization of MSCs in skeletal tissues and discusses the mechanisms of their actions in regeneration of bone in vivo. The authors describe recent findings pertaining to the efficacy of MSC therapies in animal models and in human clinical trials and bring together literature showing that the ways MSCs are extracted, expanded and implanted can considerably affect bone formation outcomes. Finally, it presents the latest knowledge on the nature of native MSCs in skeletal tissues, which provide a platform for novel in situ tissue regeneration approaches for systemic bone disease such as osteoporosis. Focuses specifically on the use of stem cells in skeletal tissue generation for a broad audience of stem cell, cancer, and bone biologists, orthopedists, oncologists, and regenerative medicine specialistsProvides a short historical 'detour' and foundational information on founding concepts, discoveries and personalities in MSC researchAssists a new generation of scientists and clinicians in digesting the multitude of journal articles on the topic by providing easily-absorbed and condensed foundational context.

Mesenchymal Stem Cells and Skeletal Regeneration

Mesenchymal Stem Cells and Skeletal Regeneration Book
Author : Elena Jones
Publisher : Unknown
Release : 2013
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This book covers our current understanding of the role of mesenchymal stem cells (MSCs) and other mesenchymal progenitors in skeletal regeneration, encompassing bone, cartilage and whole joint regeneration. The expansion reflects developments in the field to include data on the use of MSCs in drug development, growth factors, scaffolds and biomechanical manipulations for skeletal trauma and diseases, including osteoporosis and arthritis. Written for an audience of clinicians and young researchers who are exposed to MSCs in their work, this work summarizes recent findings pertaining to the definition and characterization of MSCs in skeletal tissues and discusses the mechanisms of their actions in regeneration of bone in vivo. The authors describe recent findings pertaining to the efficacy of MSC therapies in animal models and in human clinical trials and bring together literature showing that the ways MSCs are extracted, expanded and implanted can considerably affect bone formation outcomes. Finally, it presents the latest knowledge on the nature of native MSCs in skeletal tissues, which provide a platform for novel in situ tissue regeneration approaches for systemic bone disease such as osteoporosis. Focuses specifically on the use of stem cells in skeletal tissue generation for a broad audience of stem cell, cancer, and bone biologists, orthopedists, oncologists, and regenerative medicine specialistsProvides a short historical 'detour' and foundational information on founding concepts, discoveries and personalities in MSC researchAssists a new generation of scientists and clinicians in digesting the multitude of journal articles on the topic by providing easily-absorbed and condensed foundational context.

Mesenchymal Stem Cells in Skeletal Muscle Regeneration

Mesenchymal Stem Cells in Skeletal Muscle Regeneration Book
Author : Anabel Sofía Garza-Rodea
Publisher : Unknown
Release : 2011
ISBN : 9789088913235
Language : En, Es, Fr & De

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Book Description :

Download Mesenchymal Stem Cells in Skeletal Muscle Regeneration book written by Anabel Sofía Garza-Rodea, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Bone and Cartilage Regeneration

Bone and Cartilage Regeneration Book
Author : Phuc Van Pham
Publisher : Springer
Release : 2017-01-24
ISBN : 3319401440
Language : En, Es, Fr & De

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Book Description :

This invaluable resource discusses clinical applications with effects and side-effects of applications of stem cells in bone and cartilage regeneration. Each chapter is contributed by a pre-eminent scientist in the field and covers such topics as skeletal regeneration by mesenchymal stem cells, clinical improvement of mesenchymal stem cell injection in injured cartilage and osteoarthritis, Good manufacturing practice (GMP), minimal critera of stem cells for clinical applications, future directions of the discussed therapies and much more. Bone & Cartilage Regeneration and the other books in the Stem Cells in Clinical Applications series will be invaluable to scientists, researchers, advanced students and clinicians working in stem cells, regenerative medicine or tissue engineering.

Stem Cells and Bone Tissue

Stem Cells and Bone Tissue Book
Author : Rajkumar Rajendram,Victor R. Preedy,Vinood Patel
Publisher : CRC Press
Release : 2013-01-23
ISBN : 1466578416
Language : En, Es, Fr & De

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Book Description :

Stem cells potentially offer a novel therapeutic platform to treat bone disease. They also help the scientist understand the molecular and cellular aetiology of bone disorders. Gaining knowledge on the nature and application of stem cell sciences is a prerequisite for understanding their potential in treating or preventing bone disorders. Stem Cells and Bone Tissue is designed to address these areas in three sections: Introductory Text and Sources of Stem Cells for Skeletal Tissue Cellular and Molecular Aspects Conditions, Applications, Treatments and Repairs Coverage includes general aspects of stems cells, sources of stems cells, isolation and purification, applications in regeneration, nanoscale topography, myostatin (GDF-8) signalling, c-Jun, Lnk, cell-derived Factor 1/CXCR4, chromatin remodelling, osteoporosis, osteoarthritis, hypophosphatasia, osteopetrosis, osteogenesis, and many other areas of merit too numerous to mention.

Mesenchymal Stem Cells and Craniofacial Regeneration

Mesenchymal Stem Cells and Craniofacial Regeneration Book
Author : Jing Wang ,YunFeng Lin
Publisher : Bentham Science Publishers
Release : 2016-10-19
ISBN : 1681083159
Language : En, Es, Fr & De

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Book Description :

This monograph provides a current and in-depth review of scholarly information about mesenchymal stem cells and their application in the craniofacial region of the human body. Chapters in this volume cover biological and conceptual information about mesenchymal stem cells, induced pluripotent stem cells, craniofacial regeneration, new methods of scaffold fabrication, tooth regeneration and three-dimensional printing in dentistry. The book is suitable for clinicians and cell biologists aiming to gain a better understanding of the promising field of craniofacial regenerative medicine.

Stem Cells in Craniofacial Development and Regeneration

Stem Cells in Craniofacial Development and Regeneration Book
Author : George T.J. Huang,Irma Thesleff
Publisher : John Wiley & Sons
Release : 2013-02-15
ISBN : 1118498119
Language : En, Es, Fr & De

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Book Description :

Stem Cells, Craniofacial Development and Regeneration is anintroduction to stem cells with an emphasis on their role incraniofacial development. Divided into five sections, chaptersbuild from basic introductory information on the definition andcharacteristics of stem cells to more indepth explorations oftheir role in craniofacial development. Section I covers embryonicand adult stem cells with a focus on the craniofacial region, whilesections II-IV cover the development and regeneration ofcraniofacial bone, tooth, temporomandibular joint, salivary glandsand muscle. Concluding chapters describe the current, cutting-edgeresearch utilizing stem cells for craniofacial tissuebioengineering to treat lost or damaged tissue. The authoritative resource for dentistry students as well ascraniofacial researchers at the graduate and post-graduate level,Stem Cells, Craniofacial Development and Regenerationexplores the rapidly expanding field of stem cells and regenerationfrom the perspective of the dentistry and craniofacial community,and points the way forward in areas of tissue bioengineering andcraniofacial stem cell therapies.

Stem Cell Biology and Regenerative Medicine

Stem Cell Biology and Regenerative Medicine Book
Author : Mehdi Razavi
Publisher : Bentham Science Publishers
Release : 2017-10-02
ISBN : 168108578X
Language : En, Es, Fr & De

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Book Description :

Tissue engineering is an interdisciplinary field which involves the fabrication of tissues by using a porous protein scaffold, cells and bioactive molecules. The aim of tissue engineering is to enhance medical applications and procedures. This volume introduces the reader to the basics of employing pluripotent stem cells in tissue engineering. Successive chapters present knowledge about relevant tissue engineering techniques in different medical and physiological specialties including dentistry, cardiovascular physiology, hepatology, nephrology, dermatology and orthopedics. The text offers a wealth of information that will be of use to all students, bioengineers, materials scientists, chemists, physicians and surgeons concerned with the properties, performance, and the application of tissue engineering scaffolds in clinical settings.

Stem Cell and Tissue Engineering

Stem Cell and Tissue Engineering Book
Author : Song Li,Nicolas L'Heureux,Jennifer H. Elisseeff
Publisher : World Scientific
Release : 2011
ISBN : 9814317055
Language : En, Es, Fr & De

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Book Description :

Tissue engineering integrates knowledge and tools from biological sciences and engineering for tissue regeneration. A challenge for tissue engineering is to identify appropriate cell sources. The recent advancement of stem cell biology provides enormous opportunities to engineer stem cells for tissue engineering. The impact of stem cell technology on tissue engineering will be revolutionary. This book covers state-of-the-art knowledge on the potential of stem cells for the regeneration of a wide range of tissues and organs and the technologies for studying and engineering stem cells. It serves as a valuable reference book for researchers and students.

A Tissue Regeneration Approach to Bone and Cartilage Repair

A Tissue Regeneration Approach to Bone and Cartilage Repair Book
Author : Hala Zreiqat,Colin R. Dunstan,Vicki Rosen
Publisher : Springer
Release : 2014-12-05
ISBN : 3319132660
Language : En, Es, Fr & De

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Book Description :

Reviewing exhaustively the current state of the art of tissue engineering strategies for regenerating bones and joints through the use of biomaterials, growth factors and stem cells, along with an investigation of the interactions between biomaterials, bone cells, growth factors and added stem cells and how together skeletal tissues can be optimised, this book serves to highlight the importance of biomaterials composition, surface topography, architectural and mechanical properties in providing support for tissue regeneration. Maximizing reader insights into the importance of the interplay of these attributes with bone cells (osteoblasts, osteocytes and osteoclasts) and cartilage cells (chondrocytes), this book also provides a detailed reference as to how key signalling pathways are activated. The contribution of growth factors to drive tissue regeneration and stem cell recruitment is discussed along with a review the potential and challenges of adult or embryonic mesenchymal stem cells to further enhance the formation of new bone and cartilage tissues. This book serves to demonstrate the interconnectedness of biomaterials, bone/cartilage cells, growth factors and stem cells in determining the regenerative process and thus the clinical outcome.

Osteogenesis and Bone Regeneration

Osteogenesis and Bone Regeneration Book
Author : Haisheng Yang
Publisher : BoD – Books on Demand
Release : 2019-04-24
ISBN : 1789857678
Language : En, Es, Fr & De

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Book Description :

Osteogenesis is a core component of the skeletal system and depends on the well-coordinated proliferation and differentiation of osteogenic cells. Multiple signaling pathways and transcriptional factors tightly regulate the process of osteogenesis. Any abnormities in bone formation could cause severe disorders such as osteogenesis imperfecta and osteoporosis. Bone regeneration, a complex and well-orchestrated physiological process of osteogenesis, remains a medical challenge in the field of orthopedics and maxillofacial surgery. This book provides an overview of the current developments in osteogenesis and bone regeneration, including molecular and cellular mechanisms, physical therapies (low-level laser, distraction osteogenesis), biological therapies (mesenchymal stem cells, stem cell derived exosomes, inflammatory factor, Chinese medicine), as well as tissue engineering approaches promoting bone regeneration by targeting osteogenesis.

Trends in Mesenchymal Stem Cells Applications for Skeletal Muscle Repair and Regeneration

Trends in Mesenchymal Stem Cells  Applications for Skeletal Muscle Repair and Regeneration Book
Author : A.R. Caseiro
Publisher : Unknown
Release : 2015
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Skeletal muscle injuries are quite frequent in traumatic scenarios, such as war injuries or road- or work-related accidents. The skeletal muscle has good regenerative ability, but the extent or recurrence of muscle injury might impair complete structural and functional recovery. Severe tissue loss overwhelms skeletal muscle ́s intrinsic regenerative capabilities and culminates in the development of noncontractile fibrous tissue scar. Conservative RICE -based and surgical treatments show limited efficacy in terms of improving these severe cases outcomes, pressing the need for new approaches on skeletal muscle's therapy. Since the first suggestions of the potential of mesenchymal stem cells for regenerative medicine and tissue engineering, many applications have been explored for a variety of tissues and diseases, including the skeletal muscle, which is the focus of this literature review.

Skeletal Regeneration by Mesenchymal Stem Cells What Else

Skeletal Regeneration by Mesenchymal Stem Cells  What Else  Book
Author : José A. Andrades,Enrique Guerado,José Becerra,José Ma López-Puertas,Manuel Monleón,María C. Araque,Pedro Jiménez-Palomo,Plácido Zamora-Navas,Silvia Claros
Publisher : Unknown
Release : 2011
ISBN : 9789533076638
Language : En, Es, Fr & De

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Book Description :

Download Skeletal Regeneration by Mesenchymal Stem Cells What Else book written by José A. Andrades,Enrique Guerado,José Becerra,José Ma López-Puertas,Manuel Monleón,María C. Araque,Pedro Jiménez-Palomo,Plácido Zamora-Navas,Silvia Claros, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Frontiers in Stem Cell and Regenerative Medicine Research

Frontiers in Stem Cell and Regenerative Medicine Research Book
Author : Atta-ur Rahman,Shazia Anjum
Publisher : Bentham Science Publishers
Release : 2017-05-11
ISBN : 1681084759
Language : En, Es, Fr & De

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Book Description :

Stem cell and regenerative medicine research is a hot area of research which promises to change the face of medicine as it will be practiced in the years to come. Challenges in the 21st century to combat diseases such as cancer, Alzheimer and related diseases may well be addressed employing stem cell therapies and tissue regeneration. Frontiers in Stem Cell and Regenerative Medicine Research is essential reading for researchers seeking updates in stem cell therapeutics and regenerative medicine. The fifth volume of this series features reviews on vascular regeneration, neuronal tissue grafting in animal CNS disease models, template mediated biomineralization in bones, corneal endothelium differentiation and stem cell uses for managing hepatocellular carcinoma.

Stem Cells and Cancer Stem Cells Volume 4

Stem Cells and Cancer Stem Cells  Volume 4 Book
Author : M.A. Hayat
Publisher : Springer Science & Business Media
Release : 2012-02-09
ISBN : 9400728271
Language : En, Es, Fr & De

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Book Description :

Vast therapeutic applications of the following specific stem cells in disease and tissue injury are discussed: embryonic stem cells, induced pluripotent stem cells, human hair follicle stem cells, bone marrow-derived human mesenchymal stem cells, adipose-derived stem cells, periodontal/progenitor cells, cancer stem cells, and breast cancer stem cells. Because human embryonic stem cells possess the potential to produce unlimited quantities of any human cell type, considerable focus is placed on this type of stem cells in this volume. The role of cancer stem cells, specifically in breast cancer is explained. Transplantation of mesenchymal stem cells to aid the injured brain is included. Immune recovery after stem cells transplantation in severe combined immunodeficiency patients is described. The role of mesenchymal stem cells in enhancing the growth and metastasis of colon cancer is discussed. Clinical application of human follicle stem cells is presented. Treatment of malignant gliomas using genetically-modified neural stem cells as a marker is discussed. The impact of cancer stem cell hypothesis on designing new cancer therapies is explained. In the field of regenerative medicine, the use of stem cells in the repair of the central nervous system, tendon injury, and as a cardiac regenerative medicine is described. The role of DNA methylation in maintaining stemness induced pluripotent stem cells from human extraembryonic amnion cells is discussed. Insights on the understanding of molecular pathways involved in tumor biology are explained, which lead to the development of effective drugs. Information on pathways, such as hedgehog, facilitates targeted therapies in cancer.

Mesenchymal stem cells in Transplantation and Tissue Regeneration

Mesenchymal stem cells in Transplantation and Tissue Regeneration Book
Author : Martin J. Hoogduijn,Frank J. Dor
Publisher : Frontiers E-books
Release : 2013-08-23
ISBN : 2889191591
Language : En, Es, Fr & De

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Book Description :

Normal 0 false false false EN-GB X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin-top:0in; mso-para-margin-right:0in; mso-para-margin-bottom:10.0pt; mso-para-margin-left:0in; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-ansi-language:EN-GB;} Mesenchymal stem cells (MSC) have induced expansive interest from both scientific and clinical points of view over the last decennium. This interest stems from the capacity of these cells to differentiate into multiple lineages and from their secretion of growth factors that can activate progenitor cells, which make MSC potentially applicable for tissue regenerative purposes. When exposed to inflammatory conditions, MSC furthermore exhibit immunosuppressive properties. The reduction of chronic or acute inflammatory responses by MSC may halt the development of injury and allow regenerative processes to take place. This prospective has initiated attempts to use MSC as an immunosuppressive and regenerative agent in transplantation and regeneration of tissues like kidney, liver, heart, bone and multiple others. Nevertheless, the conditions under which MSC therapy is effective and via what mechanisms MSC operate are, in particular in in vivo settings, not clear. The route of administration and the reigning immunological conditions are likely to be key for the efficacy of MSC. Studies have demonstrated for instance that MSC may be immunostimulatory under immunological quiescent conditions. Whereas some reports indicate that homing of MSC to inflamed tissues and their secretion of growth and anti-inflammatory factors are responsible for their effect, others show that MSC rapidly disappear after administration and may not have time to actively contribute to immunosuppression and tissue repair. Many aspects of MSC have to be clarified in order to develop efficient therapies. In this special topic, different views on the mechanisms of immunomodulation and regeneration by MSC and on the possible applications of MSC in transplantation and tissue regeneration will be put together.

Frontiers in Skeletal Muscle Wasting Regeneration and Stem Cells

Frontiers in Skeletal Muscle Wasting  Regeneration and Stem Cells Book
Author : Carlos Hermano J. Pinheiro,Lucas Guimarães-Ferreira
Publisher : Frontiers Media SA
Release : 2016-05-25
ISBN : 2889198324
Language : En, Es, Fr & De

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Book Description :

The search for knowledge on cellular and molecular mechanisms involved in skeletal muscle mass homeostasis and regeneration is an exciting scientific area and extremely important to develop therapeutic strategies for neuromuscular disorders and conditions related to muscle wasting. The mechanisms involved in the regulation of skeletal muscle mass and regeneration consist of molecular signaling pathways modulating protein synthesis and degradation, bioenergetics alterations and preserved function of muscle stem cells. In the last years, different kinds of stem cells has been reported to be localized into skeletal muscle (satellite cells, mesoangioblasts, progenitor interstitial cells and others) or migrate from non-muscle sites, such as bone marrow, to muscle tissue in response to injury. In addition, myogenic progenitor cells are also activated in skeletal muscle wasting disorders. The goal of this research topic is to highlight the available knowledge regarding skeletal muscle and stem cell biology in the context of both physiological and pathological conditions. Our purpose herein is to facilitate better dissemination of research into skeletal muscle physiology field. Frontiers in Physiology is a journal indexed in: PubMed Central, Scopus, Google Scholar, DOAJ, CrossRef.