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Mesenchymal Stem Cell Derived Exosomes

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Mesenchymal Stem Cell Derived Exosomes

Mesenchymal Stem Cell Derived Exosomes Book
Author : Yaoliang Tang,Buddhadeb Dawn
Publisher : Academic Press
Release : 2015-09-02
ISBN : 0128004975
Language : En, Es, Fr & De

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Book Description :

Mesenchymal stem cell-derived exosomes are at the forefront of research in two of the most high profile and funded scientific areas – cardiovascular research and stem cells. Mesenchymal Stem Cell Derived Exosomes provides insight into the biofunction and molecular mechanisms, practical tools for research, and a look toward the clinical applications of this exciting phenomenon which is emerging as an effective diagnostic. Primarily focused on the cardiovascular applications where there have been the greatest advancements toward the clinic, this is the first compendium for clinical and biomedical researchers who are interested in integrating MSC-derived exosomes as a diagnostic and therapeutic tool. Introduces the MSC-exosome mediated cell-cell communication Covers the major functional benefits in current MSC-derived exosome studies Discusses strategies for the use of MSC-derived exosomes in cardiovascular therapies

Mesenchymal Stem Cell derived Exosomes Ameliorate Disease in a Model of Relapsing remitting Multiple Sclerosis

Mesenchymal Stem Cell derived Exosomes Ameliorate Disease in a Model of Relapsing remitting Multiple Sclerosis Book
Author : Oliver Yuan
Publisher : Unknown
Release : 2018
ISBN : 9780438291003
Language : En, Es, Fr & De

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Book Description :

Multiple sclerosis (MS) is a demyelinating autoimmune disease that results in neurological disability. There are now 15 medications approved to treat relapsing-remitting MS, however, none of the available therapies halts disease progression or directly reverses central nervous system damage. The two salient features of MS pathology involve an over-activation of the inflammatory response in the central nervous system (CNS) and auto-antibody targeting of the myelin sheath that insulates axons. Remyelination in MS does not occur due to the lack of differentiation of oligodendrocyte progenitor cells (OPCs) into myelin-secreting mature oligodendrocytes. Mesenchymal stem cell-derived exosomes (mExo) are small extracellular vesicles secreted by mesenchymal stem cells (MSCs) and are capable of recapitulating many of the anti-inflammatory and neuroprotective effects of MSCs with a potentially simplified path to commercialization. Here we demonstrate that mExo significantly reduces the inflammatory response of lymphocytes, potentiates upregulation of regulatory T cells (Tregs) and induces OPC maturation. mExo significantly reduced symptoms in a murine model of relapsing-remitting MS, and increased Treg engraftment. These data indicate that mExo warrant further preclinical investigation as a regenerative therapy for the future treatment of MS.

0410 Effect of Combined Platelet Rich Plasma and Mesenchymal Stem Cell Derived Exosomes on Chondrocyte Gene Expression

0410   Effect of Combined Platelet Rich Plasma and Mesenchymal Stem Cell Derived Exosomes on Chondrocyte Gene Expression Book
Author : Anonim
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

INTRODUCTION: Platelet-rich plasma (PRP) and mesenchymal stem cells (MSCs) serve as two of the most popular potential therapies to enhance cartilage regeneration. Platelets contain alpha granules that house a plethora of growth factors, cytokines, and other molecules that may potentiate tissue healing. Some studies posit that MSCs exert regenerative effects via paracrine signaling [1] which may be mediated by exosomes. Defined as extracellular vesicles released from the fusion of a cytosolic multivesicular body with the cell membrane, exosomes have been implicated in intracellular communication and molecular transport [2]. Early evidence suggests that MSC-derived exosomes possess chondroprotective and anti-inflammatory properties [3]. Similarly, PRP has been shown to increase chondrocyte proliferation and gene expression indicative of extracellular matrix (ECM) production [4]. However, no studies have examined the concomitant effects of PRP and MSC-derived exosomes on chondrocyte gene expression in both a neutral and inflammatory environment. It was hypothesized that chondrocytes cultured in a combination of PRP and exosomes would demonstrate enhanced gene expression suggestive of ECM synthesis and decreased inflammation than chondrocytes grown with PRP or exosomes in isolation.METHODS: Articular chondrocytes were harvested from articular surfaces of bovine ankle joints and cultured in DMEM-F12 medium with 10% fetal bovine serum (FBS) and 1% antibiotic-antimycotic (AA) solution. MSCs were isolated from the bone marrow of Sprague-Dawley rats and cultured in low-glucose DMEM medium with 15% FBS and 1% AA. Both cell lines were incubated with 5% CO2 at 37u00b0C. PRP was obtained from one healthy donor using a Regen PRP kit. Following a previously published protocol [5], exosomes were obtained from MSCs as a 100K pellet. Chondrocytes were seeded at 50,000 cells/well into 24-well plates. They were partitioned into one control (media only) and five experimental conditions: exosomes alone (Exo), 1% unactivated PRP (1u), 5u, combined exosomes and 1% uPRP (Exo1), and Exo5. Exosomes were added to the appropriate treatment groups at a concentration of 10 u03bcg/ml. All conditions were further allocated into one of two environments: with or without IL-1u03b2 (10 ng/ml) to simulate an osteoarthritic or neutral environment respectively. Following 1 and 3 days, RNA was harvested, isolated, and reverse transcribed into cDNA. Quantitative RT-PCR was then performed (n = 3 per condition), using glyceraldehyde 3-phosphate dehydrogenase (GAPDH) as the endogenous control, for the following target genes: aggrecan (ACAN), sex-determining region Y box 9 (SOX9), alpha-1 chain of type I collagen (Col1), alpha-1 chain of type II collagen (Col2), and matrix metalloproteinase 3 (MMP3), thioredoxin-interacting protein (TXNIP), and proliferating cell nuclear antigen (PCNA). The data were analyzed according to the 2-u0394u0394CT method. Because significant deviations from normality were observed, within-day comparisons across conditions and within-condition comparisons across days were analyzed with Kruskal-Wallis tests followed by Conover-Iman post hoc tests. Due to the large number of comparisons performed, the Benjamini-Hochberg procedure was employed to control the false discovery rate. Significance was determined if p

Regenerative Potential of Mesenchymal Stem Cell Derived Exosomes

Regenerative Potential of Mesenchymal Stem Cell Derived Exosomes Book
Author : Andrew P. Wong
Publisher : Unknown
Release : 2019
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Bone defects are a pervasive complication arising from many clinical conditions, both mechanical and pathological. Current treatments for large bony defects focus on applying bone grafts or synthetic materials to the defect area. Cell-based-and especially stem-cell-therapies have advanced greatly thanks to increasing attention focused on their ability to generate new tissues in situ with biomechanical properties approaching that of native tissue, but they suffer from their own shortcomings as well. Exosomes have been shown to play critical roles in cell-signaling and tissue regeneration and are therefore potentially ideal therapeutic vehicles for treating bone defects. Exosomes are small microvesicles counted amongst stem cells' paracrine factors capable of delivering nucleic acid and enzymatic protein cargoes in a targeted 2 manner. Our previous studies have shown that hM. S.C-Exosomes are both proliferative and chemotactic, inhibit inflammatory cytokine production, and suppress osteoclast differentiation. Our long term goal is to develop hMSC-Exosome as a clinical therapy for bone regeneration. The objectives of this study were to determine the ability of hMSC-Exosome to enhance bone healing in a rat calvarial defect model, and to further investigate the integrity of the exosome under certain storage conditions. The specific aims of this study were: 1) To determine the osteogenic potential of hMSC-Exosomes in rat calvarial defects, and 2) To determine the impact of variable storage conditions on the integrity of exosomes. To investigate in vivo regenerative potential, rats with surgically-created craniotomy defects were treated with hMSC-Exosome suspension via a collagen gel matrix. After 4 weeks, the calvaria were harvested and analyzed via micro-CT. Volumetric micro-CT analysis showed that hMSC-Exosome could significantly enhance center healing, structural integrity, and growth uniformity in a calvarial defect model. Western blot and TEM showed thorough destruction of surface protein markers and decreased membrane integrity in lyophilized exosome fraction; moderate progressive surface protein marker loss and aggregation were observed with increasing freeze-thaw cycles. In summary, hMSC-Exosome is a promising therapeutic for treatment of bone defects.

Stem Cell Drugs A New Generation of Biopharmaceuticals

Stem Cell Drugs   A New Generation of Biopharmaceuticals Book
Author : Phuc Van Pham
Publisher : Springer
Release : 2018-10-25
ISBN : 3319993283
Language : En, Es, Fr & De

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Book Description :

This invaluable resource discusses the current revolution in stem cell-based drugs and their potential use in clinical applications. Each chapter is contributed by a pre-eminent scientist in the field. An introductory section presents current stem cell drugs and stem cell-based products and a discussion of production, quality control, mechanisms, and efficacy. Following sections include discussions on stem cell-derived microvesicles based products, and derived exosomes based products. Stem Cell Drugs - A New Generation of Biopharmaceuticals and the other books in the Stem Cells in Clinical Applications series are invaluable to scientists, researchers, advanced students and clinicians working in stem cells, regenerative medicine or tissue engineering. This groundbreaking volume is also essential reading for those researching or studying drug development or pharmaceutical science.

Mesenchymal Stem Cell Exosomes Mediate Angiogenesis and Contain Neurotrophic Proteins

Mesenchymal Stem Cell Exosomes Mediate Angiogenesis and Contain Neurotrophic Proteins Book
Author : Johnathon David Anderson
Publisher : Unknown
Release : 2015
ISBN : 9781339543802
Language : En, Es, Fr & De

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Book Description :

Mesenchymal stem cells (MSC) are known to facilitate healing of damaged tissues through the secretion of trophic factors. Recent studies show that MSC derived exosomes function as paracrine effectors of angiogenesis and neurotrophic factors, however, the identity of which components of the exosome proteome responsible for these effects remains elusive. To address this we used high-resolution isoelectric focusing coupled liquid chromatography tandem mass spectrometry (HiRIEF LC-MS/MS), an unbiased high throughput proteomics approach to comprehensively characterize the proteinaceous contents of MSCs and MSC derived exosomes. We probed the proteome of MSCs and MSC derived exosomes from cells cultured under expansion conditions and under ischemic tissue simulated conditions to elucidate key angiogenic paracrine and neurotrophic effectors present and potentially differentially expressed in these conditions. In total, 6,342 proteins were identified in MSCs and 1,927 proteins in MSC derived exosomes, representing to our knowledge the first time these proteomes have been probed comprehensively. Multi-layered analyses identified several putative paracrine effectors of angiogenesis and neurite outgrowth present in MSC exosomes and increased in expression in MSCs exposed to ischemic tissue-simulated conditions; these include platelet derived growth factor (PDGF), epidermal growth factor (EGF), fibroblast growth factor (FGF) and most notably nuclear factor-kappaB (NFkB) signaling pathway proteins. Collectively, the results of our proteomic analysis show that MSC derived exosomes contain a robust profile of angiogenic and neurotrophic effectors, which have potential for the treatment of ischemic tissue-related diseases.

Role of Exosomes in Biological Communication Systems

Role of Exosomes in Biological Communication Systems Book
Author : Faisal A. Alzahrani,Islam M. Saadeldin
Publisher : Springer Nature
Release : 2020-11-20
ISBN : 9811565996
Language : En, Es, Fr & De

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Book Description :

This book reviews the role of exosomes and extracellular vesicles in both normal and pathological conditions. It first explains isolation methods for exosomes, and analyzes their fine structure and biological functions. Further, it highlights exosomes’ role as the key regulator in embryonic-maternal communication, and in the pathogenesis of various diseases, including cancer and urogenital, infectious, and neurodegenerative diseases. Moreover, it reviews the latest advances in using stem-cell-derived exosomes as a cell-free strategy in regenerative medicine, as well as the potential of exosomal microRNA as a promising non-invasive biomarker and targetable factor in cancer diagnosis and treatment. Lastly, it explores the use of natural and synthetic exosomes as nano-vehicles for efficient drug delivery.

Therapeutic Applications of Mesenchymal Stem Cell Vesicles

Therapeutic Applications of Mesenchymal Stem Cell Vesicles Book
Author : Milad Riazifar
Publisher : Unknown
Release : 2017
ISBN : 9780355414066
Language : En, Es, Fr & De

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Book Description :

Mesenchymal Stem Cell-derived Exosomes Promote Neurologic Recovery in Experimental Autoimmune Encephalomyelitis model of Multiple Sclerosis By Milad Riazifar Doctor of Philosophy in Pharmacological Sciences University of California, 2017 Professor Weian Zhao, Chair Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS) in which autoreactive T cells attack CNS, resulting in demyelination, neuronal injury and death, which account for the neurological disability. Preclinical studies revealed immunomodulatory and immunosuppressive properties of mesenchymal stem cell (MSC) to treat MS. However, Lung entrapment, maldifferentiation, phenotype change and potentially tumor formation are current challenges for stem cell therapy. The much smaller size of MSC-derived exosomes (Exo), allow reduced lung entrapment, achieve superior biocompatibility, are more stable and expose fewer risks, which together makes them an attractive alternative.Here, using experimental autoimmune encephalomyelitis (EAE) as a MS mouse model (n = 30), we show that systemic injection of MSC-Exo (150 microg) result in sustained recovery and improved motor function (p

Genomics Proteomics and Metabolomics

Genomics  Proteomics  and Metabolomics Book
Author : Babak Arjmand
Publisher : Springer Nature
Release : 2019-11-14
ISBN : 3030277275
Language : En, Es, Fr & De

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Book Description :

This book provides thorough coverage of high-throughput OMICs technologies for the monitoring of stem cells and regenerative medicine. Specific topics covered include the genomics, proteomics, and metabolomics aspects of regenerative medicine, metabolic profiling of mesenchymal stem cells, genome profiling of mesenchymal stem cells, OMICs monitoring of stem cell-derived exosomes, stem cell proteomics, lipidomics, OMICs profiling of cancer (stem) cells, and finally ethical considerations of OMICs-based investigations. Chapters are authored by world-renowned scientists who have valuable expertise in the field of OMICs and regenerative medicine. Genomics, Proteomics, and Metabolomics: Stem Cells Monitoring in Regenerative Medicine, part of Springer’s Stem Cell Biology and Regenerative Medicine series, is essential reading for researchers, clinicians, biologists, biochemists, and pharmaceutical experts conducting research in the fields of stem cell biology, molecular aspects of stem cell research, tissue engineering, regenerative medicine, cellular therapy, OMICs, bioinformatics, and ethics.

The Role of Human M S C Derived Exosomes in the Treatment of Periodontal Diseases

The Role of Human M S C Derived Exosomes in the Treatment of Periodontal Diseases Book
Author : Sonia S. Talegaonkar
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Periodontal disease affects 47% of Americans over 30. Characterized by microbial dysbiosis and unregulated inflammation, severe periodontitis causes degradation of bone and soft tissue around teeth. Current treatments have limited regenerative outcomes and frequent reinfection by harmful bacteria. Human mesenchymal stem cells (hM. S. Cs) have been shown to promote wound healing and tissue regeneration. Many therapeutic benefits of hMSCs are due to their secretome products, like exosomes. Our long-term goal is to develop periodontal therapies with hMSC exosomes. The objectives of this study were to determine the effect of hMSC-derived exosomes on cellular activity of hMSCs and investigate whether hMSC exosome treatment reduces pro-inflammatory cytokine production in LPS-activated RAW264.7 cells. The specific aims of this study were: 1) Determine the characteristics of hMSC-derived exosomes, 2) Determine the biological effect of exosomes on cellular activity of hMSCs, 3) Determine whether exosomes treatment can inhibit cytokine production in activated RAW264.7 cells, and 4) Determine the role of exosomal miRNA in pro-inflammatory cytokine production of RAW264.7 cells. To investigate, exosomes were first harvested from hMSCs culture media through ultracentrifugation. Exosomes were then observed under a transmission electron microscope (TEM) and assessed for surface markers using Western Blot. A transwell migration assay was used to evaluate the chemotactic effect of exosomes. To study the effect of exosomes on stem cell proliferation, exosomes were administered to hMSCs. The immunogenicity of MSC exosome was also evaluated. After 72 hours, cells were lysed and DNA was measured. To study anti-inflammatory effects of exosomes, LPS stimulated RAW264.7 cells were treated with exosomes. Interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF[alpha]) levels of supernatant were measured by ELISA. To study exosomal miRNA, exosomal miRNAs were overexpressed in RAW264.7 cells and these cells were stimulated with LPS. IL-6 and TNF[alpha] were measured by ELISA. TEM images showed that exosomes are nano-sized vesicles (~100 nm). Western blot images showed that CD63 and CD81 are enriched in exosomes compared to total cell lysates. Exosome treatment increased cell proliferation and migration in hMSCs. At the doses that are chemotactic and mitogenic, MSC exosomes had minimal effect on the inflammatory cytokine IL-6 production. Treatment with exosomes significantly decreased IL-6 and TNF[alpha] production in RAW264.7 cells activated by LPS. Transfecting RAW264.7 cells with exosomal miR-760 significantly decreased IL-6 production, but had minimal effect on TNF[alpha]. Our results indicate that exosomes have a pleiotropic activity, which includes stimulating stem cell migration and proliferation, and mitigating the inflammatory response. Therefore, hMSC exosome delivery is promising for the treatment of periodontal diseases.

Osteogenesis and Bone Regeneration

Osteogenesis and Bone Regeneration Book
Author : Haisheng Yang
Publisher : BoD – Books on Demand
Release : 2019-04-24
ISBN : 1789857678
Language : En, Es, Fr & De

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Book Description :

Osteogenesis is a core component of the skeletal system and depends on the well-coordinated proliferation and differentiation of osteogenic cells. Multiple signaling pathways and transcriptional factors tightly regulate the process of osteogenesis. Any abnormities in bone formation could cause severe disorders such as osteogenesis imperfecta and osteoporosis. Bone regeneration, a complex and well-orchestrated physiological process of osteogenesis, remains a medical challenge in the field of orthopedics and maxillofacial surgery. This book provides an overview of the current developments in osteogenesis and bone regeneration, including molecular and cellular mechanisms, physical therapies (low-level laser, distraction osteogenesis), biological therapies (mesenchymal stem cells, stem cell derived exosomes, inflammatory factor, Chinese medicine), as well as tissue engineering approaches promoting bone regeneration by targeting osteogenesis.

Exosomes as Therapeutic Systems

Exosomes as Therapeutic Systems Book
Author : Robert Steven Conlan,Deyarina Gonzalez,Bruna Corradetti,Ines Mendes Pinto
Publisher : Frontiers Media SA
Release : 2021-10-01
ISBN : 2889713768
Language : En, Es, Fr & De

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Book Description :

Download Exosomes as Therapeutic Systems book written by Robert Steven Conlan,Deyarina Gonzalez,Bruna Corradetti,Ines Mendes Pinto, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Exosomes Stem Cells and MicroRNA

Exosomes  Stem Cells and MicroRNA Book
Author : Karl L. Mettinger,Pranela Rameshwar,Vinod Kumar
Publisher : Springer
Release : 2018-04-07
ISBN : 3319744704
Language : En, Es, Fr & De

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Book Description :

This volume provides insight into the pivotal roles of stem cells, exosomes and other microvesicles in biofunction and molecular mechanisms and their therapeutic potential in translational nanomedicine. It further highlights evidence from recent studies as to how stem cell derived exosomes and microRNAs may restore and maintain tissue homeostasis, enable cells to recover critical cellular functions and begin repair regeneration. These early studies in animal models of aging also show evidence of improved immune, cardiovascular and cognitive functions as well as improved health span and life span. The use of exosomes from body fluids to define specific biomarkers for various tumors may also clear the path to patient-targeted treatments by developing exosome-derived microRNA based cancer therapeutics. It is essential reading for graduate students, research fellow and biomedical researchers in academia or the pharmaceutical or biotech industries.

Exosomes in Cardiovascular Diseases

Exosomes in Cardiovascular Diseases Book
Author : Junjie Xiao,Sanda Cretoiu
Publisher : Springer
Release : 2017-09-19
ISBN : 9811043973
Language : En, Es, Fr & De

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Book Description :

The book provides and intensive overview on exosomes in cardiovascular diseases, its potential as biomarkers, as well as pathological and therapeutic effects. It firstly describes the general aspects of exosomes including the definition, formation and secretion of exosomes and highlight their roles as biomarkers and pathological and therapeutic effects in cardiovascular diseases as well. Secondly, basic aspects of exosomes including the purification methods of exosomes, exosomes content, and functional roles of the cardiovascular exosomes are summarized. Thirdly, exosomes as biomarkers of cardiovascular diseases are overviewed including their roles in diagnosis, prognosis and reaction to therapy. Fourthly, pathological effects of exosomes and therapeutic effects of exosomes are highlighted. Finally, future prospects of exosomes in cardiovascular research would be provided. This is an essential reference for researchers working in cell biology and regeneration, as well as clinicians such as cardiologist.

Safety Efficacy and Mechanisms of Action of Mesenchymal Stem Cell Therapies

Safety  Efficacy and Mechanisms of Action of Mesenchymal Stem Cell Therapies Book
Author : Guido Moll,Martin Johannes Hoogduijn,James A. Ankrum
Publisher : Frontiers Media SA
Release : 2020-07-24
ISBN : 2889636003
Language : En, Es, Fr & De

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Book Description :

Download Safety Efficacy and Mechanisms of Action of Mesenchymal Stem Cell Therapies book written by Guido Moll,Martin Johannes Hoogduijn,James A. Ankrum, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Cell Biology and Translational Medicine Volume 2

Cell Biology and Translational Medicine  Volume 2 Book
Author : Kursad Turksen
Publisher : Springer
Release : 2018-11-28
ISBN : 3030041700
Language : En, Es, Fr & De

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Book Description :

Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions. This online first book series 'Cell Biology and Translational Medicine (CBTMED)' as part of SpringerNature’s longstanding and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the second volume of a continuing series.

Stem Cells

Stem Cells Book
Author : Mariusz Z. Ratajczak
Publisher : Springer Nature
Release : 2020-01-02
ISBN : 3030312062
Language : En, Es, Fr & De

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Book Description :

Since different types of stem cells for therapeutic applications have recently been proposed, this timely volume explores various sources of stem cells for tissue and organ regeneration and discusses their advantages and limitations. Also discussed are pros and cons for using embryonic stem cells, induced pluripotent stem cells, and adult stem cells isolated from postnatal tissues. Different types of adult stem cells for therapeutic applications are also reviewed, including hematopoietic stem cells, epidermal stem cells, endothelial progenitors, neural stem cells, mesenchymal stem cells, and very small embryonic-like stem cells. This book also addresses paracrine effects of stem cells in regenerative medicine that are mediated by extracellular microvesicles and soluble secretome. Finally, potential applications of stem cells in cardiology, gastroenterology, neurology, immunotherapy, and aging are presented. This is an ideal book for students and researchers working in the stem cell research field.

Mesenchymal Stromal Cells as Tumor Stromal Modulators

Mesenchymal Stromal Cells as Tumor Stromal Modulators Book
Author : Marcela Bolontrade,Mariana García
Publisher : Academic Press
Release : 2016-10-24
ISBN : 0128031034
Language : En, Es, Fr & De

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Book Description :

Mesenchymal stromal/ stem cells (MSCs) represent a heterogeneous cell population with immunomodulating, tissue repairing, differentiating, migratory and angiogenic abilities, making them important tools for clinical and translational research. An understanding of the role of MSCs in modulating tumor growth provides a glimpse into their role in non-pathological tissue remodeling and potential regenerative tissue therapies. Mesenchymal Stromal Cells as Tumor Stromal Modulators is a comprehensive source for the understanding of the role of MSCs as ubiquitous connective tissue cell components, which may have both direct and indirect effects on the tumor microenvironment and potential for regenerative therapeutics for various diseases. Using cancer as a model disease, this book explores the transformative role MSCs play in the recruitment of disease cells, cell repair and immunological defenses. Explores the biology of mesenchymal stromal cells (MSCs) and tissue related function Discusses the bidirectional communication between tumor stroma and MSCs derived from bone marrow, from adipose tissue and from other tissue types Provides in-depth analysis of the effects of MSCs on key processes that regulate disease progression, such as angiogenesis, metastatic potential, invasion, proliferation, tumor immune privileges

Microenvironment Derived Stem Cell Plasticity

Microenvironment Derived Stem Cell Plasticity Book
Author : Jelena Krstic,Marietta Herrmann,Ivana Gadjanski,Slavko Mojsilovic
Publisher : Frontiers Media SA
Release : 2017-12-21
ISBN : 2889453448
Language : En, Es, Fr & De

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Book Description :

Plasticity is the hallmark of stem cells. At the same time, stem cells, like any other cell type, are influenced by their microenvironment and respond to it accordingly. A specific microenvironment is defined by a variety of factors, including biological and chemical factors, cell-cell interactions, but also metabolic and mechanical cues. Such dynamic and specialized microenvironment where the stem cells reside is considered a stem cell niche. Tissue injury as well as malignant tissue alterations lead to changes in the niche influencing the plasticity and biology of residing stem cells. Similarly, the niche changes upon tissue damage, which eventually induces differentiation of stem cells and ultimately regeneration of the tissue.

Update on Mesenchymal and Induced Pluripotent Stem Cells

Update on Mesenchymal and Induced Pluripotent Stem Cells Book
Author : Khalid Ahmed Al-Anazi
Publisher : BoD – Books on Demand
Release : 2020-04-22
ISBN : 1789238072
Language : En, Es, Fr & De

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Book Description :

This book represents an updated overview on selected topics related to mesenchymal stem cells as well as induced pluripotent stem cells. The book is divided into three main sections that cover several topics including: sources of both stem cell types, their preparation and general properties, as well as their therapeutic indications and clinical utilization with particular attention given to their use in infectious diseases, osteoarthritis, as well as immunological disorders.