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Mechanotransduction Cell Signaling To Cell Response

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Mechanotransduction

Mechanotransduction Book
Author : Paul A. Sundaram
Publisher : Academic Press
Release : 2020-11-18
ISBN : 0128178833
Language : En, Es, Fr & De

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Book Description :

Mechanotransduction: Cell Signaling to Cell Response covers the cell machinery responsible for the process of mechanotransduction and the manner in which cells respond to an external mechanical stimulus. The effect of mechanical stimulus on individual cells and entire tissues is discussed, with an emphasis on the practical results of this physiological process. Mechanotransduction of stem cells and cancerous cells are also covered, along with future directions in this yet nascent field. This book gives insights on basic processes that occur (or may occur) in the human body as a result of the application of mechanical stimulus. It is ideal for both biomedical engineers and biologists, and is an ideal resource for teaching. It provides a current state of conceptual and practical aspects of the field and will enable students and professionals to venture further into this incipient area which is of fundamental importance to biomedical engineering and biology fields. Covers fundamental concepts of signaling in cells as a result of mechanical stimulus Includes the physiological results of mechanical stimulus on the human body Explores the advantages of mechanical loads on the human body

Mechanosensitivity and Mechanotransduction

Mechanosensitivity and Mechanotransduction Book
Author : Irina Kiseleva,Andre Kamkin
Publisher : Springer Science & Business Media
Release : 2010-11-18
ISBN : 904819881X
Language : En, Es, Fr & De

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Book Description :

This book presents the latest findings in the field of research of mechanosensitivity and mechanotransduction in different cells and tissues. Mechanosensitivity and mechanotransduction of the heart and vascular cells, in the lung, in bone and joint tissues, in sensor systems and in blood cells are described in detail. This Volume focuses on molecular mechanisms of mechanosensitivity and mechanotransduction via cytoskeleton. Integrin-mediated mechanotransduction, the role of actin cytoskeleton and the role of other cytoskeletal elements are discussed. It contains a detailed description of several stretch-induced signaling cascades with multiple levels of crosstalk between different pathways. It contains a description of the role of nitric oxide in regulation of cardiac activity and in regulation of mechanically gated channels in the heart. In the heart mechanical signals are propagated into the intracellular space primarily via integrin-linked complexes, and are subsequently transmitted from cell to cell via paracrine signaling. Biochemical signals derived from mechanical stimuli activate both acute phosphorylation of signaling cascades, such as in the PI3K, FAK, and ILK pathways, and long-term morphological modii cations via intracellular cytoskeletal reorganization and extracellular matrix remodelling. Cellular and molecular effects of mechanical stretch on vascular cells are also discussed. This Volume highlights the role of mechanotransduction in the lung, in bone and joint tissues. For the first time mechanosensitivity and mechanotransduction in blood cells are discussed. It contains new insights into mechanosensitive K+ channels functioning in mouse B lymphocytes. This book is a unique collection of reviews outlining current knowledge and future developments in this rapidly growing field. Currently, investigations of the molecular mechanisms of mechanosensitivity and mechanotransduction are focused on several issues. The majority of studies investigate intracellular signaling pathways. Knowledge of the mechanisms which underlie these processes is necessary for understanding of the normal functioning of different organs and tissues and allows to predict changes, which arise due to alterations of their environment. Possibly such knowledge will allow the development of new methods of artificial intervention and therapies. This book brings up the problem closer to the experts in related medical and biological sciences as well as practicing doctors besides just presenting the latest achievements in the field.

Cellular Mechanotransduction

Cellular Mechanotransduction Book
Author : Mohammad R. K. Mofrad,Roger D. Kamm
Publisher : Cambridge University Press
Release : 2009-11-23
ISBN : 1316139476
Language : En, Es, Fr & De

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Book Description :

'Mechanotransduction' is the term for the ability, first described by 19th-century anatomist Julius Wolff, of living tissues to sense mechanical stress and respond by tissue remodeling. More recently, the scope of mechanotransduction has been expanded to include the sensation of stress, its translation into a biochemical signal, and the sequence of biological responses it produces. This book looks at mechanotransduction in a more restricted sense, focusing on the process of stress sensing and transducing a mechanical force into a cascade of biochemical signals. This stress has become increasingly recognized as one of the primary and essential factors controlling biological functions, ultimately affecting the function of the cells, tissues, and organs. A primary goal of this broad book is also to help define the new field of mechanomics, which attempts to describe the complete mechanical state of a biological system.

Mechanotransduction

Mechanotransduction Book
Author : Anonim
Publisher : Academic Press
Release : 2014-07-29
ISBN : 0123983274
Language : En, Es, Fr & De

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Book Description :

Progress in Molecular Biology and Translational Science provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology. It contains contributions from leaders in their fields and abundant references. Volume 126 features in-depth reviews that focus on the tools required to investigate mechanotransduction. Additional chapters focus on how we can use these tools to answer fundamental questions about the interaction of physical forces with cell biology, morphogenesis, and function of mature structures. Chapters in the volume are authored by a unique combination of cell biologists and engineers, providing a range of perspectives on mechanotransduction. Provides a unique combination of perspectives from biologists and engineers Engaging to people of many training backgrounds

Tissue Engineering

Tissue Engineering Book
Author : Clemens Van Blitterswijk,Jan De Boer
Publisher : Academic Press
Release : 2014-12-10
ISBN : 0124202101
Language : En, Es, Fr & De

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Book Description :

Tissue Engineering is a comprehensive introduction to the engineering and biological aspects of this critical subject. With contributions from internationally renowned authors, it provides a broad perspective on tissue engineering for students coming to the subject for the first time. In addition to the key topics covered in the previous edition, this update also includes new material on the regulatory authorities, commercial considerations as well as new chapters on microfabrication, materiomics and cell/biomaterial interface. Effectively reviews major foundational topics in tissue engineering in a clear and accessible fashion Includes state of the art experiments presented in break-out boxes, chapter objectives, chapter summaries, and multiple choice questions to aid learning New edition contains material on regulatory authorities and commercial considerations in tissue engineering

Cellular Mechanotransduction Mechanisms in Cardiovascular and Fibrotic Diseases

Cellular Mechanotransduction Mechanisms in Cardiovascular and Fibrotic Diseases Book
Author : Anonim
Publisher : Academic Press
Release : 2021-10-22
ISBN : 0128215240
Language : En, Es, Fr & De

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Book Description :

Endothelial Signaling, Mechanotransduction, Vascular Biology and Atherosclerosis, Volume 87, the latest release in the Current Topics in Membranes series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics. Each chapter is written by an international board of authors. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in "Current Topics in Membranes" series Updated release includes the latest information on Endothelial Signaling, Mechanotransduction, Vascular Biology and Atherosclerosis

TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades

TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades Book
Author : Wolfgang B. Liedtke, MD, PH.D.
Publisher : CRC Press
Release : 2006-09-29
ISBN : 1420005847
Language : En, Es, Fr & De

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Book Description :

Since the first TRP ion channel was discovered in Drosophila melanogaster in 1989, the progress made in this area of signaling research has yielded findings that offer the potential to dramatically impact human health and wellness. Involved in gateway activity for all five of our senses, TRP channels have been shown to respond to a wide range of stimuli from both within and outside the cell body. How we sense heat and cold, how we taste food, how eggs are fertilized, how the heart expands and contracts is each dependent on the function of these channels. While no single book could possibly cover all the research being undertaken, TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades presents the most advanced compilation of work in this area to date. All 31 chapters are written by international pioneers working at the vanguard of TRP ion channel research. They explain much about the pivotal function and behavior of these channels, which are most exquisitely tuned to their specific tasks, and delve into how researchers are putting this knowledge to use in the development of novel pharmaceuticals, which may well prove effective in ameliorating treatment-resistant conditions including cancer, heart disease, inflammation, and immune system dysfunctions. Individual chapters shed light on selected topics of interest in the TRP arena, such as signal transduction in axonal path-finding, and in vascular, renal, and auditory functions, as well as pain. The text also covers subjects as diverse as mating and fertilization, inflammatory pain, and mechanisms of pheromone detection in mammals. While the book presents much new insight and explores findings that will be of interest to those involved with advanced research, it also includes significant background material for those looking to familiarize themselves with this exceptionally promising path of inquiry.

Mechanobiology in Health and Disease

Mechanobiology in Health and Disease Book
Author : Stefaan Verbruggen
Publisher : Academic Press
Release : 2018-08-09
ISBN : 0128129530
Language : En, Es, Fr & De

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Book Description :

Mechanobiology in Health and Disease brings together contributions from leading biologists, clinicians, physicists and engineers in one convenient volume, providing a unified source of information for researchers in this highly multidisciplinary area. Opening chapters provide essential background information on cell mechanotransduction and essential mechanobiology methods and techniques. Other sections focus on the study of mechanobiology in healthy systems, including bone, tendons, muscles, blood vessels, the heart and the skin, as well as mechanobiology studies of pregnancy. Final chapters address the nascent area of mechanobiology in disease, from the study of bone conditions, skin diseases and heart diseases to cancer. A discussion of future perspectives for research completes each chapter in the volume. This is a timely resource for both early-career and established researchers working on mechanobiology. Provides an essential digest of primary research from many fields and disciplines in one convenient volume Covers both experimental approaches and descriptions of mechanobiology problems from mathematical and numerical perspectives Addresses the hot topic of mechanobiology in disease, a particularly dynamic field of frontier science

Mechanosensitive Ion Channels

Mechanosensitive Ion Channels Book
Author : Anonim
Publisher : Elsevier
Release : 2011-09-21
ISBN : 0080494404
Language : En, Es, Fr & De

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Book Description :

Current Topics in Membranes provides a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. Each volume is a guest edited compendium of membrane biology. This series has been a mainstay for practicing scientists and students interested in this critical field of biology. Articles covered in the volume include ENaC Proteins in Vascular Smooth Muscle Mechanotransduction; Regulation of the Mechano-Gated K2P Channel TREK-1 by Membrane Phospholipids; MechanoTRPs and TRPA1; TRPC; The Cytoskeletal Connection to Ion Channels as a Potential Mechanosensory Mechanism. Lessons From Polycystin-2 (TRPP2); Lipid Stress at Play: Mechanosensitivity of Voltage-Gated Channels; Hair Cell Mechanotransduction: The Dynamic Interplay between Structure and Function; Pharmacology of Hair Cell MS Channels; Hair Cell Mechanotransduction; Models of Hair Cell Mechanotrasduction; Touch; Mechanosensitive Ion Channels in Dystrophic Muscle; Mechanotransduction in Endothelial Cells; MS Channels in Tumor Cell Migration; Mechanosensitive Channels in Regulating Smooth Muscle Contraction in the GI; Mechanosensitive Ion Channels in Blood-Pressure-Sensing Baroreceptor Neurons.

T Cell Development

T Cell Development Book
Author : Rémy Bosselut,Melanie S. Vacchio
Publisher : Humana Press
Release : 2015-08-22
ISBN : 9781493928088
Language : En, Es, Fr & De

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Book Description :

​This volume provides simple and accessible experiment protocols to explore thymus biology. T-Cell Development: Methods and Protocols is divided into three parts presenting short reviews on T cell development, analysis strategies, protocols for cell preparation, flow cytometry analyses, and multiple aspects of thymocyte biology. As a volume in the highly successful Methods in Molecular Biology series, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Concise and easy-to-use, T-Cell Development: Methods and Protocols aims to ensure successful results in the further study of this vital field.

Mechanobiology of Cell Cell and Cell Matrix Interactions

Mechanobiology of Cell Cell and Cell Matrix Interactions Book
Author : A. Wagoner Johnson,Brendan Harley
Publisher : Springer Science & Business Media
Release : 2011-02-21
ISBN : 1441980830
Language : En, Es, Fr & De

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Book Description :

Mechanobiology of Cell-Matrix Interactions focuses on characterization and modeling of interactions between cells and their local extracellular environment, exploring how these interactions may mediate cell behavior. Studies of cell-matrix interactions rely on integrating engineering, (molecular and cellular) biology, and imaging disciplines. Recent advances in the field have begun to unravel our understanding of how cells gather information from their surrounding environment, and how they interrogate such information during the cell fate decision making process. Topics include adhesive and integrin-ligand interactions; extracellular influences on cell biology and behavior; cooperative mechanisms of cell-cell and cell-matrix interactions; the mechanobiology of pathological processes; (multi-scale) modeling approaches to describe the complexity or cell-matrix interactions; and quantitative methods required for such experimental and modeling studies.

Molecular and Cellular Mechanobiology

Molecular and Cellular Mechanobiology Book
Author : Shu Chien,Adam J. Engler,Peter Yingxiao Wang
Publisher : Springer
Release : 2016-08-10
ISBN : 1493956175
Language : En, Es, Fr & De

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Book Description :

This book will cover the cutting-edge developments in molecular and cellular mechanobiology to date. Readers will have a clear understanding of mechanobiology at the molecular and cellular levels, encompassing the mechanosensors, transducers, and transcription. An integrative approach across different scales from molecular sensing to mechanotransduction and gene modulation for physiological regulation of cellular functions will be explored, as well as applications to pathophysiological states in disease. A comprehensive understanding of the roles of physicochemical microenvironment and intracellular responses in determining cellular function in health and disease will also be discussed.

Current Topics in Membranes

Current Topics in Membranes Book
Author : Anonim
Publisher : Academic Press
Release : 1992-01-08
ISBN : 9780080585109
Language : En, Es, Fr & De

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Book Description :

Current Topics in Membranes

Cell Signaling in Vascular Inflammation

Cell Signaling in Vascular Inflammation Book
Author : Jahar Bhattacharya
Publisher : Springer Science & Business Media
Release : 2007-11-15
ISBN : 1592599095
Language : En, Es, Fr & De

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Book Description :

A comprehensive survey by leading basic and clinical researchers of the signal transduction mechanisms responsible for lung inflammation, including vascular hyperpermeability, white cell accumulation, and vascular remodeling. The authors cut across disciplines to bring together a broad-based presentation of inflammatory challenge, both in the initial phases of the inflammatory response, as well as in the more prolonged phase of genomic involvement. The book illuminates not only the processes of lung inflammation, but also the potential for developing new therapeutic strategies to combat inflammatory lung disease.

Mechanotransduction Chondroyctye

Mechanotransduction   Chondroyctye Book
Author : DR AMRIT RATTAN K. BAIDWAN - MACFARLAND
Publisher : Authorhouse UK
Release : 2021-12-03
ISBN : 9781665595209
Language : En, Es, Fr & De

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Book Description :

A seminal and novel finding in a scientific study of Dr Amrit Rattan K Baidwan MacFarland (Amrit K Macfarland), as Senior Scientist/ Molecular Geneticist, resulted in the discovery of key signalling pathways in chondrocytes (cartilage explants) in response to cyclic and static loading of connective tissues. The work was presented as a first proof in multiple peer reviewed international conferences, in the United Kingdom, United States, most of Europe, Asia, and the Middle East. The pre-requisite for planning new and novel research experiments and coping with future trends in science is a thorough analysis of the present state of knowledge and in finding new ways of thinking and planning. On this basis, new research hypotheses and strategies will have to be built. This book aims to present a short review of key concepts around Dr MacFarland's research experiments on signal transduction in diverse systems, such as cancer blood brain barrier studies, coronary heart disease, mechanotranduction mechanisms in connective tissues mainly articular cartilage and meniscus with special attention paid to the reactions of these two tissues, as responses in vitro loading model regimens. The current interest in loading stems from how little we know of the aetiology of osteoarthritis a degenerative joint disease, the most crippling of musculoskeletal disorder and diseases. Signal transduction mechanisms are also examined in endothelial and smooth muscle and the role of cholesterol ester transfer protein in coronary heart disease. The object of Dr MacFarland's scientific and medical research in signal transduction is ambitious, as both scientific research leading to therapeutic remedies needed high ideals setting goals; to give novel relevant results as was the case of the discovery of the first signalling molecule in her research in a unique biological system, as well as the response of connective tissue cells to mechanical stimulus. Therefore, far off as it may be, the prevention of diseases must be the ultimate objective and the overwhelming character of the problems, compels scientists in specific in the age of nano technology to seek cures and create the means of prevention of the disease. Aspects of her studies show the relevance in high impact sports injuries and daily working conditions, whether they degrade or maintain the health of joints in general, and benefit or harm joints and health. AUTHORHOUSE - ACADEMIC PRESS

Cellular Signaling in Health and Disease

Cellular Signaling in Health and Disease Book
Author : Martin Beckerman
Publisher : Springer Science & Business Media
Release : 2009-05-28
ISBN : 9780387981734
Language : En, Es, Fr & De

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Book Description :

In today’s world, three great classes of non-infectious diseases – the metabolic syndromes (such as type 2 diabetes and atherosclerosis), the cancers, and the neurodegenerative disorders – have risen to the fore. These diseases, all associated with increasing age of an individual, have proven to be remarkably complex and difficult to treat. This is because, in large measure, when the cellular signaling pathways responsible for maintaining homeostasis and health of the body become dysregulated, they generate equally stable disease states. As a result the body may respond positively to a drug, but only for a while and then revert back to the disease state. Cellular Signaling in Health and Disease summarizes our current understanding of these regulatory networks in the healthy and diseased states, showing which molecular components might be prime targets for drug interventions. This is accomplished by presenting models that explain in mechanistic, molecular detail how a particular part of the cellular signaling web operates properly in health and improperly in disease. The stability of the health- and disease-associated states is dynamic and supported by multiple feedback loops acting positively and negatively along with linkages between pathways. During the past few years an ongoing series of important discoveries have been made that advance our understanding of how the body works and may guide us on how to better deal with these diseases. These include the discovery of chronic inflammation as a causal factor in all of these disease classes, the appearance of reactive oxygen species as a messenger molecule that can act both positively and negatively, the propensity of proteins to misfold into aggregation- and disease-prone forms, and the rise of epigenetics including the emergence of small non-coding RNA with important regulatory functions out of the so-called junk RNA. Chapters are devoted to each of these classes of findings with additional details integrated into the chapters dealing directly with the diseases. The connections responsible for maintaining stability are explored in depth.

Collagen

Collagen Book
Author : Peter Fratzl
Publisher : Springer Science & Business Media
Release : 2008-05-10
ISBN : 0387739068
Language : En, Es, Fr & De

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Book Description :

Not only does this book provide a comprehensive review of current research advances in collagen structure and mechanics, it also explores this biological macromolecule’s many applications in biomaterials and tissue engineering. Readers gain an understanding of the structure and mechanical behavior of type I collagen and collagen-based tissues in vertebrates across all length scales, from the molecular (nano) to the organ (macro) level.

Orthodontics E Book

Orthodontics   E Book Book
Author : Lee W. Graber,Robert L. Vanarsdall,Katherine W. L. Vig,Greg J. Huang
Publisher : Elsevier Health Sciences
Release : 2016-07-15
ISBN : 0323444326
Language : En, Es, Fr & De

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Book Description :

Comprehensive, cutting-edge content prepares you for today’s orthodontics! Orthodontics: Current Principles and Techniques, 6th Edition provides evidence-based coverage of orthodontic diagnosis, planning strategies, and treatment protocols, including esthetics, genetics, temporary anchorage devices, aligners, technology-assisted biomechanics, and much more. New to this edition is an Expert Consult website using videos and additional visuals to show concepts difficult to explain with words alone. Expert Consult also adds three online-only chapters, research updates, and a fully searchable version of the text. From respected editors Lee Graber, Robert Vanarsdall, Katherine Vig, and Greg Huang, along with a veritable Who’s Who of expert contributors, this classic reference has a concise, no-nonsense approach to treatment that makes it the go-to book for orthodontic residents and practitioners! Comprehensive coverage provides a one-stop resource for the field of orthodontics, including foundational theory and the latest on the materials and techniques used in today’s practice. Experienced, renowned editors lead a team of expert, international contributors, bringing the most authoritative clinical practice and supporting science from the best and brightest in the industry. More than 3,400 images include a mixture of radiographs, full-color clinical photos, and anatomic or schematic line drawings, showing examples of treatment, techniques, and outcomes. Extensive references make it easy to look up the latest in orthodontic research and evidence-based information, and all references also appear online. Detailed, illustrated case studies show the decision-making process, showing the consequences of various treatment techniques over time. NEW! Seven all-new chapters include Orthodontic Diagnosis and Treatment Planning with Cone-Beam Computed Tomography Imaging; Upper Airway, Cranial Morphology, and Sleep Apnea; Management of Impactions; Iatrogenic Effects of Orthodontic Appliances; Minimally and Non-Invasive Approaches to Accelerate Tooth Movement; Management of Dental Luxation and Avulsion Injuries in the Permanent Dentition; and Patient Management and Motivation for the Child and Adolescent Patient. NEW! Expert Consult website includes online-only chapters, instructional videos, many references linked to PubMed, and research updates including additional case studies. UPDATED CHAPTERS include Biomechanical Considerations with Temporary Anchorage Devices, Bonding in Orthodontics, Clear Aligner Treatment, Lingual Appliance Treatment, Psychological Aspects of Diagnosis and Treatment, Clinically Relevant Aspects of Dental Materials Science in Orthodontics, The Biologic Basis of Orthodontics, and more. New co-editor Greg J. Huang is joined by new contributors who are highly regarded experts within their respective subspecialties in orthodontics.

Disease and the Hippo Pathway

Disease and the Hippo Pathway Book
Author : Carsten Gram Hansen
Publisher : MDPI
Release : 2019-11-22
ISBN : 3039217763
Language : En, Es, Fr & De

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Book Description :

The Hippo pathway is a highly dynamic cellular signaling nexus that plays central roles in multiple cell types and regulates regeneration, metabolism, and development. The Hippo pathway integrates mechanotransduction, cell polarity, inflammation, and numerous types of paracrine signaling. If not tightly regulated, dysregulated Hippo pathway signaling drives the onset and progression of a range of diseases, including fibrosis and cancer. The molecular understanding of the Hippo pathway is rapidly evolving. This Special Issue contains ten articles contributed by established and up-and-coming Hippo pathway experts that, as a whole, provides an up-to-date overview of how dysregulated Hippo pathway activity is a common driver of specific diseases. The articles have a particular focus on the underlying molecular and cellular mechanisms that cause the Hippo pathway to go awry, and especially how this drives disease. The articles analyze disease-specific as well as common themes, which provides valuable insights into the fundamental molecular mechanisms in the dysfunctioning Hippo pathway, and thereby offer practical insights into potential future therapeutic intervention strategies.

Cell Mechanoresponse at Cell Material Interface

Cell Mechanoresponse at Cell Material Interface Book
Author : Qiang Wei,Elisabetta Ada Cavalcanti-Adam,Liming Bian
Publisher : Frontiers Media SA
Release : 2022-02-01
ISBN : 2889741966
Language : En, Es, Fr & De

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Book Description :

Download Cell Mechanoresponse at Cell Material Interface book written by Qiang Wei,Elisabetta Ada Cavalcanti-Adam,Liming Bian, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.