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Mechanobiology

Mechanobiology Book
Author : Simon Rawlinson
Publisher : John Wiley & Sons
Release : 2017-02-06
ISBN : 1118966147
Language : En, Es, Fr & De

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Book Description :

An emerging field at the interface of biology and engineering, mechanobiology explores the mechanisms by which cells sense and respond to mechanical signals—and holds great promise in one day unravelling the mysteries of cellular and extracellular matrix mechanics to cure a broad range of diseases. Mechanobiology: Exploitation for Medical Benefit presents a comprehensive overview of principles of mechanobiology, highlighting the extent to which biological tissues are exposed to the mechanical environment, demonstrating the importance of the mechanical environment in living systems, and critically reviewing the latest experimental procedures in this emerging field. Featuring contributions from several top experts in the field, chapters begin with an introduction to fundamental mechanobiological principles; and then proceed to explore the relationship of this extensive force in nature to tissues of musculoskeletal systems, heart and lung vasculature, the kidney glomerulus, and cutaneous tissues. Examples of some current experimental models are presented conveying relevant aspects of mechanobiology, highlighting emerging trends and promising avenues of research in the development of innovative therapies. Timely and important, Mechanobiology: Exploitation for Medical Benefit offers illuminating insights into an emerging field that has the potential to revolutionise our comprehension of appropriate cell biology and the future of biomedical research.

The Mathematics of Mechanobiology

The Mathematics of Mechanobiology Book
Author : Antonio DeSimone,Benoît Perthame,Alfio Quarteroni,Lev Truskinovsky
Publisher : Springer Nature
Release : 2020-06-29
ISBN : 3030451976
Language : En, Es, Fr & De

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Book Description :

This book presents the state of the art in mathematical research on modelling the mechanics of biological systems – a science at the intersection between biology, mechanics and mathematics known as mechanobiology. The book gathers comprehensive surveys of the most significant areas of mechanobiology: cell motility and locomotion by shape control (Antonio DeSimone); models of cell motion and tissue growth (Benoît Perthame); numerical simulation of cardiac electromechanics (Alfio Quarteroni); and power-stroke-driven muscle contraction (Lev Truskinovsky). Each section is self-contained in terms of the biomechanical background, and the content is accessible to all readers with a basic understanding of differential equations and numerical analysis. The book disentangles the phenomenological complexity of the biomechanical problems, while at the same time addressing the mathematical complexity with invaluable clarity. The book is intended for a wide audience, in particular graduate students and applied mathematicians interested in entering this fascinating field.

Mechanobiology Handbook Second Edition

Mechanobiology Handbook  Second Edition Book
Author : Jiro Nagatomi,Eno Essien Ebong
Publisher : CRC Press
Release : 2018-12-07
ISBN : 042981674X
Language : En, Es, Fr & De

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Book Description :

Mechanobiology—the study of the effects of mechanics on biological events—has evolved to answer numerous research questions. Mechanobiology Handbook 2nd Edition is a reference book for engineers, scientists, and clinicians who are interested in mechanobiology and a textbook for senior undergraduate to graduate level students of this growing field. Readers will gain a comprehensive review of recent research findings as well as elementary chapters on solid mechanics, fluid mechanics, and molecular analysis techniques. The new edition presents, in addition to the chapters of the first edition, homework problem sets that are available online and reviews of research in uncovered areas. Moreover, the new edition includes chapters on statistical analysis, design of experiments and optical imaging. The editors of this book are researchers and educators in mechanobiology. They realized a need for a single volume to assist course instructors as a guide for didactic teaching of mechanobiology to a diverse student body. A mechanobiology course is frequently made up of both undergraduate and graduate students pursuing degrees in engineering, biology, or integrated engineering and biology. Their goal was to present both the elementary and cutting-edge aspects of mechanobiology in a manner that is accessible to students from many different academic levels and from various disciplinary backgrounds. Moreover, it is their hope that the readers of Mechanobiology Handbook 2nd Edition will find study questions at the end of each chapter useful for long-term learning and further discussion. Comprehensive collection of reviews of recent research Introductory materials in mechanics, biology, and statistics Discussion of pioneering and emerging mechanobiology concepts Presentation of cutting-edge mechanobiology research findings across various fields and organ systems End of chapter study questions, available online Considering the complexity of the mechanics and the biology of the human body, most of the world of mechanobiology remains to be studied. Since the field is still developing, the Mechanobiology Handbook raises many different viewpoints and approaches with the intention of stimulating further research endeavours.

Molecular and Cellular Mechanobiology

Molecular and Cellular Mechanobiology Book
Author : Shu Chien,Adam J. Engler,Peter Yingxiao Wang
Publisher : Springer
Release : 2016-08-10
ISBN : 1493956175
Language : En, Es, Fr & De

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Book Description :

This book will cover the cutting-edge developments in molecular and cellular mechanobiology to date. Readers will have a clear understanding of mechanobiology at the molecular and cellular levels, encompassing the mechanosensors, transducers, and transcription. An integrative approach across different scales from molecular sensing to mechanotransduction and gene modulation for physiological regulation of cellular functions will be explored, as well as applications to pathophysiological states in disease. A comprehensive understanding of the roles of physicochemical microenvironment and intracellular responses in determining cellular function in health and disease will also be discussed.

Mechanobiology of Cell Cell and Cell Matrix Interactions

Mechanobiology of Cell Cell and Cell Matrix Interactions Book
Author : A. Wagoner Johnson,Brendan Harley
Publisher : Springer Science & Business Media
Release : 2011-02-21
ISBN : 9781441980830
Language : En, Es, Fr & De

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Book Description :

Mechanobiology of Cell-Matrix Interactions focuses on characterization and modeling of interactions between cells and their local extracellular environment, exploring how these interactions may mediate cell behavior. Studies of cell-matrix interactions rely on integrating engineering, (molecular and cellular) biology, and imaging disciplines. Recent advances in the field have begun to unravel our understanding of how cells gather information from their surrounding environment, and how they interrogate such information during the cell fate decision making process. Topics include adhesive and integrin-ligand interactions; extracellular influences on cell biology and behavior; cooperative mechanisms of cell-cell and cell-matrix interactions; the mechanobiology of pathological processes; (multi-scale) modeling approaches to describe the complexity or cell-matrix interactions; and quantitative methods required for such experimental and modeling studies.

Integrative Mechanobiology

Integrative Mechanobiology Book
Author : Yu Sun,Deok-Ho Kim,Craig A. Simmons
Publisher : Cambridge University Press
Release : 2015-11-12
ISBN : 1107078393
Language : En, Es, Fr & De

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Book Description :

Experts describe state-of-the-art micro-nano techniques for cell mechanobiology and introduce the most recent advances in the field.

Mechanobiology

Mechanobiology Book
Author : Glen L. Niebur
Publisher : Elsevier
Release : 2019-12-01
ISBN : 0128179325
Language : En, Es, Fr & De

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Book Description :

Mechanobiology: From Molecular Sensing to Disease will provide a review of the current state of understanding of mechanobiology and its role in health and disease. It covers: Current understanding of the main molecular pathways by which cells sense and respond to mechanical stimuli, A review of diseases that with known or purported mechanobiological underpinnings; The role of mechanobiology in tissue engineering and regenerative medicine; Experimental methods to capture mechanobiological phenomena; Computational models in mechanobiology. Presents our current understanding of the main molecular pathways by which cells sense and respond to mechanical stimuli Provides a review of diseases with known or purported mechanobiological underpinnings Includes the role of mechanobiology in tissue engineering and regenerative medicine Covers experimental methods to capture mechanobiological phenomena

Hemodynamics and Mechanobiology of Endothelium

Hemodynamics and Mechanobiology of Endothelium Book
Author : Tzung K. Hsiai,Brett Blackman,Hanjoong Jo
Publisher : World Scientific
Release : 2010
ISBN : 9814280410
Language : En, Es, Fr & De

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Book Description :

The book represents a paradigm shift from the traditional static model of investigation of oxidative biology to the dynamic model of vascular oxidative stress. The investigation of vascular biology and cardiovascular medicine is made possible by the use of tissue engineering, nanotechnology and stem cell research. This is the first textbook to target a wide readership from academia to industry and government agencies in the field of cardiovascular diseases.

Cellular and Biomolecular Mechanics and Mechanobiology

Cellular and Biomolecular Mechanics and Mechanobiology Book
Author : Amit Gefen
Publisher : Springer Science & Business Media
Release : 2010-12-02
ISBN : 9783642142185
Language : En, Es, Fr & De

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Book Description :

This book describes these exciting new developments, and presents experimental and computational findings that altogether describe the frontier of knowledge in cellular and biomolecular mechanics, and the biological implications, in health and disease. The book is written for bioengineers with interest in cellular mechanics, for biophysicists, biochemists, medical researchers and all other professionals with interest in how cells produce and respond to mechanical loads.

Mechanobiology

Mechanobiology Book
Author : J. F. Stoltz
Publisher : IOS Press
Release : 2008
ISBN : 9781586039271
Language : En, Es, Fr & De

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Book Description :

This book covers the proceedings of the Fifth Symposium on Mechanobiology of Cartilage and Chondrocyte. Mechanobiology can be now considered as a vigorous branch of biomechanics, biorheology and physiology mainly concerned with the study of the influence of mechanical forces on cells and tissues and their clinical or therapeutical applications. As we are now in the age of proteomics, genomics and cell micro mechanical approaches, suing methods like laser tweezers or confocal microscopy, mechanobiology brings new challenges. With such new research, mechanobiology promises new diagnostic and therapeutic approaches. In other respect there has been increasing interest over recent years in the fundamental role played by local mechanical parameters in chondrocyte regulations and cartilage dysfunctions as a first step in the development of osteoarthritis. These proceedings are sub-divided into four parts: Theoretical approaches and mechanobiology of chondrocyte; Cartilage and chondrocyte studies; Osteoarthritis: inflammation degradation and clinical approaches; and, Cartilage engineering

Lung The Developmental Morphogenesis Mechanobiology And Stem Cells

Lung  The  Developmental Morphogenesis  Mechanobiology  And Stem Cells Book
Author : Ahmed El-hashash,Eiman Abdel Meguid
Publisher : World Scientific
Release : 2019-01-29
ISBN : 9813277084
Language : En, Es, Fr & De

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Book Description :

With detailed scientific background and up-to-date research, this book examines recent developmental and cell biology, mechanobiology and stem cell biology discoveries to help provide a better understanding of lung development, repair and regeneration.Lung regeneration is an urgent therapeutic priority. The current major challenge is the generation of complex vascularized structures that can ultimately support or replace impaired lung function. Recent discoveries in biomedical engineering are analysed within the structural context of the lung to help provide a better understanding of the innovative solutions that could be used for restoring normal morphogenesis and regeneration of the lung. This also includes insights from basic developmental mechanisms of human lung development through the derivation and identification of stem cells, both from the early embryo as well as from differentiated organs and tissues.Suitable for a wide range of readers, including physicians and surgeons, scientists and researchers, and undergraduate and postgraduate students, this guide is an essential read for those working in the field of lung disease and development.

Multiscale Modeling in Biomechanics and Mechanobiology

Multiscale Modeling in Biomechanics and Mechanobiology Book
Author : Suvranu De,Wonmuk Hwang,Ellen Kuhl
Publisher : Springer
Release : 2014-10-10
ISBN : 1447165993
Language : En, Es, Fr & De

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Book Description :

Presenting a state-of-the-art overview of theoretical and computational models that link characteristic biomechanical phenomena, this book provides guidelines and examples for creating multiscale models in representative systems and organisms. It develops the reader's understanding of and intuition for multiscale phenomena in biomechanics and mechanobiology, and introduces a mathematical framework and computational techniques paramount to creating predictive multiscale models. Biomechanics involves the study of the interactions of physical forces with biological systems at all scales – including molecular, cellular, tissue and organ scales. The emerging field of mechanobiology focuses on the way that cells produce and respond to mechanical forces – bridging the science of mechanics with the disciplines of genetics and molecular biology. Linking disparate spatial and temporal scales using computational techniques is emerging as a key concept in investigating some of the complex problems underlying these disciplines. Providing an invaluable field manual for graduate students and researchers of theoretical and computational modelling in biology, this book is also intended for readers interested in biomedical engineering, applied mechanics and mathematical biology.

Mechanobiology Handbook

Mechanobiology Handbook Book
Author : Jiro Nagatomi
Publisher : CRC Press
Release : 2011-03-15
ISBN : 1420091220
Language : En, Es, Fr & De

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Book Description :

Mechanobiology-the study of the effects of mechanical environments on the biological processes of cells-has evolved from traditional biomechanics via the incorporation of strong elements of molecular and cell biology. Currently, a broad range of organ systems are being studied by surgeons, physicians, basic scientists, and engineers. These mechanob

Mechanobiology in Health and Disease

Mechanobiology in Health and Disease Book
Author : Stefaan Verbruggen
Publisher : Academic Press
Release : 2018-08-09
ISBN : 0128129530
Language : En, Es, Fr & De

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Book Description :

Mechanobiology in Health and Disease brings together contributions from leading biologists, clinicians, physicists and engineers in one convenient volume, providing a unified source of information for researchers in this highly multidisciplinary area. Opening chapters provide essential background information on cell mechanotransduction and essential mechanobiology methods and techniques. Other sections focus on the study of mechanobiology in healthy systems, including bone, tendons, muscles, blood vessels, the heart and the skin, as well as mechanobiology studies of pregnancy. Final chapters address the nascent area of mechanobiology in disease, from the study of bone conditions, skin diseases and heart diseases to cancer. A discussion of future perspectives for research completes each chapter in the volume. This is a timely resource for both early-career and established researchers working on mechanobiology. Provides an essential digest of primary research from many fields and disciplines in one convenient volume Covers both experimental approaches and descriptions of mechanobiology problems from mathematical and numerical perspectives Addresses the hot topic of mechanobiology in disease, a particularly dynamic field of frontier science

Continuum Modeling in Mechanobiology

Continuum Modeling in Mechanobiology Book
Author : Larry A. Taber
Publisher : Springer Nature
Release : 2020-06-15
ISBN : 3030432092
Language : En, Es, Fr & De

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Book Description :

This book examines key theoretical tools that are currently used to develop mathematical models as an aid in understanding the biological response of cells and tissues to mechanical stimuli. Problems in growth and remodeling, tissue and organ development, and functional adaptation are all covered. Chapters on tensor analysis and nonlinear elasticity provide the necessary background for understanding the engineering theories that are currently used to solve challenges in mechanobiology. This is an ideal book for biomechanical engineers who work on problems in mechanobiology and tissue engineering.

Basic Orthopaedic Biomechanics Mechano biology

Basic Orthopaedic Biomechanics   Mechano biology Book
Author : Van C. Mow,Rik Huiskes
Publisher : Lippincott Williams & Wilkins
Release : 2005
ISBN : 9780781739337
Language : En, Es, Fr & De

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Book Description :

Biomaterials / Ahmed El-Ghannam and Paul Ducheyne -- Biomechanics of the spine / Ian A. F. Stokes and James C. Iatridis -- Biomechanics of fracture fixation and fracture healing / Lutz E. Claes and Keita Ito -- Biomechanics and preclinical testing of artificial joints: the hip / Rik Huiskes and Jan Stolk -- Biomechanics of total knee replacement designs / Peter S. Walker.

Skeletal Function and Form

Skeletal Function and Form Book
Author : Dennis R. Carter,Gary S. Beaupré
Publisher : Cambridge University Press
Release : 2007-08-25
ISBN : 9780521714754
Language : En, Es, Fr & De

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Book Description :

The intimate relationship between form and function inherent in the design of animals is perhaps nowhere more evident than in the musculoskeletal system. In the bones, cartilage, tendons, ligaments, and muscles of all vertebrates there is a graceful and efficient physical order. This book is about how function determines form. It addresses the role of mechanical factors in the development, adaptation, maintenance, ageing and repair of skeletal tissues. The authors refer to this process as mechanobiology and develop their theme within an evolutionary framework. They show how the normal development of skeletal tissues is influenced by mechanical stimulation beginning in the embryo and continuing throughout life into old age. They also show how degenerative disorders such as arthritis and osteoporosis are regulated by the same mechanical processes that influence development and growth. Skeletal Function and Form bridges important gaps among disciplines, providing a common ground for understanding, and will appeal to a wide audience of bioengineers, zoologists, anthropologists, palaeontologists and orthopaedists.

Forces in Biology Cell and Developmental Mechanobiology and Its Implications in Disease

Forces in Biology   Cell and Developmental Mechanobiology and Its Implications in Disease Book
Author : Selwin K. Wu,Michael Smutny,Samantha J. Stehbens,Guillermo A. Gomez
Publisher : Frontiers Media SA
Release : 2020-12-11
ISBN : 2889662179
Language : En, Es, Fr & De

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Book Description :

Download Forces in Biology Cell and Developmental Mechanobiology and Its Implications in Disease book written by Selwin K. Wu,Michael Smutny,Samantha J. Stehbens,Guillermo A. Gomez, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Mechanobiology of the Endothelium

Mechanobiology of the Endothelium Book
Author : Helim Aranda-Espinoza
Publisher : CRC Press
Release : 2015-02-25
ISBN : 1482207257
Language : En, Es, Fr & De

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Book Description :

The endothelium is an excellent example of where biology meets physics and engineering. It must convert mechanical forces into chemical signals to maintain homeostasis. It also controls the immune response, drug delivery through the vasculature, and cancer metastasis. Basic understanding of these processes is starting to emerge and the knowledge gained from research is now being used in applications from drug delivery to imaging modalities. This book reviews current knowledge in mechanobiology of the endothelium and its implications for the development of theranostic devices.

Modern Mechanobiology

Modern Mechanobiology Book
Author : Juhyun Lee,Sharon Gerecht,Hanjoong Jo,Tzung Hsiai
Publisher : CRC Press
Release : 2021-02-25
ISBN : 1000020924
Language : En, Es, Fr & De

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Book Description :

Modern mechanobiology converges both engineering and medicine to address personalized medicine. This book is built on the previously well-received edition, Hemodynamics and Mechanobiology of Endothelium. The central theme is "omic" approaches to mechanosignal transduction underlying tissue development, injury, and repair. A cadre of investigators has contributed to the chapters, enriching the interface between mechanobiology and precision medicine for personalized diagnosis and intervention. The book begins with the fundamental basis of vascular disease in response to hemodynamic shear stress and then details cardiovascular development and regeneration, valvular and cardiac morphogenesis, mechanosensitive microRNA and histone unfolding, computational fluid dynamics, and light-sheet imaging. This edition represents a paradigm shift from traditional biomechanics and signal transduction to transgenic models, including novel zebrafish and chick embryos, and targets a wider readership from academia to industry and government agencies in the field of mechanobiology.