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Mechanobiology in Health and Disease

Mechanobiology in Health and Disease Book
Author : Stefaan Verbruggen
Publisher : Academic Press
Release : 2018-06
ISBN : 9780128129524
Language : En, Es, Fr & De

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Book Description :

Mechanobiology in Health and Disease brings together contributions from leading biologists, clinicians, physicists and engineers in one convenient volume, providing a unified source of information for researchers in this highly multidisciplinary area. Opening chapters provide essential background information on cell mechanotransduction and essential mechanobiology methods and techniques. Other sections focus on the study of mechanobiology in healthy systems, including bone, tendons, muscles, blood vessels, the heart and the skin, as well as mechanobiology studies of pregnancy. Final chapters address the nascent area of mechanobiology in disease, from the study of bone conditions, skin diseases and heart diseases to cancer. A discussion of future perspectives for research completes the volume. This is a timely resource for both early-career and established researchers working on mechanobiology. Provides an essential digest of primary research from many fields and disciplines in one convenient volume Covers both experimental approaches and descriptions of mechanobiology problems from mathematical and numerical perspectives Addresses the hot topic of mechanobiology in disease, a particularly dynamic field of frontier science

Vascular Mechanobiology in Physiology and Disease

Vascular Mechanobiology in Physiology and Disease Book
Author : Markus Hecker,Dirk J. Duncker
Publisher : Springer Nature
Release : 2021-03-10
ISBN : 3030631648
Language : En, Es, Fr & De

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Book Description :

This volume of the series Cardiac and Vascular Biology presents the most relevant aspects of vascular mechanobiology along with many more facets of this fascinating, timely and clinically highly relevant field. Mechanotransduction, mechanosensing, fluid shear stress, hameodynamics and cell fate, are just a few topics to name. All important aspects of vascular mechanobiology in health and disease are reviewed by some of the top experts in the field. This volume, together with a second title on cardiac mechanobiology featured in this series, will be of high relevance to scientists and clinical researchers in the area of vascular biology, cardiology and biomedical engineering.

Mechanobiology in Health and Disease

Mechanobiology in Health and Disease Book
Author : Stefaan Verbruggen
Publisher : Academic Press
Release : 2018-08-09
ISBN : 0128129530
Language : En, Es, Fr & De

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Book Description :

Mechanobiology in Health and Disease brings together contributions from leading biologists, clinicians, physicists and engineers in one convenient volume, providing a unified source of information for researchers in this highly multidisciplinary area. Opening chapters provide essential background information on cell mechanotransduction and essential mechanobiology methods and techniques. Other sections focus on the study of mechanobiology in healthy systems, including bone, tendons, muscles, blood vessels, the heart and the skin, as well as mechanobiology studies of pregnancy. Final chapters address the nascent area of mechanobiology in disease, from the study of bone conditions, skin diseases and heart diseases to cancer. A discussion of future perspectives for research completes each chapter in the volume. This is a timely resource for both early-career and established researchers working on mechanobiology. Provides an essential digest of primary research from many fields and disciplines in one convenient volume Covers both experimental approaches and descriptions of mechanobiology problems from mathematical and numerical perspectives Addresses the hot topic of mechanobiology in disease, a particularly dynamic field of frontier science

Mechanobiology

Mechanobiology Book
Author : Glen L. Niebur
Publisher : Elsevier
Release : 2019-12-01
ISBN : 0128179325
Language : En, Es, Fr & De

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Book Description :

Mechanobiology: From Molecular Sensing to Disease will provide a review of the current state of understanding of mechanobiology and its role in health and disease. It covers: Current understanding of the main molecular pathways by which cells sense and respond to mechanical stimuli, A review of diseases that with known or purported mechanobiological underpinnings; The role of mechanobiology in tissue engineering and regenerative medicine; Experimental methods to capture mechanobiological phenomena; Computational models in mechanobiology. Presents our current understanding of the main molecular pathways by which cells sense and respond to mechanical stimuli Provides a review of diseases with known or purported mechanobiological underpinnings Includes the role of mechanobiology in tissue engineering and regenerative medicine Covers experimental methods to capture mechanobiological phenomena

Molecular and Cellular Mechanobiology

Molecular and Cellular Mechanobiology Book
Author : Shu Chien,Adam J. Engler,Peter Yingxiao Wang
Publisher : Springer
Release : 2016-08-10
ISBN : 1493956175
Language : En, Es, Fr & De

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Book Description :

This book will cover the cutting-edge developments in molecular and cellular mechanobiology to date. Readers will have a clear understanding of mechanobiology at the molecular and cellular levels, encompassing the mechanosensors, transducers, and transcription. An integrative approach across different scales from molecular sensing to mechanotransduction and gene modulation for physiological regulation of cellular functions will be explored, as well as applications to pathophysiological states in disease. A comprehensive understanding of the roles of physicochemical microenvironment and intracellular responses in determining cellular function in health and disease will also be discussed.

Cellular and Biomolecular Mechanics and Mechanobiology

Cellular and Biomolecular Mechanics and Mechanobiology Book
Author : Amit Gefen
Publisher : Springer Science & Business Media
Release : 2010-12-02
ISBN : 3642142184
Language : En, Es, Fr & De

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Book Description :

This book describes these exciting new developments, and presents experimental and computational findings that altogether describe the frontier of knowledge in cellular and biomolecular mechanics, and the biological implications, in health and disease. The book is written for bioengineers with interest in cellular mechanics, for biophysicists, biochemists, medical researchers and all other professionals with interest in how cells produce and respond to mechanical loads.

Mechanobiology Handbook

Mechanobiology Handbook Book
Author : Jiro Nagatomi
Publisher : CRC Press
Release : 2011-03-15
ISBN : 1420091212
Language : En, Es, Fr & De

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Book Description :

Mechanobiology—the study of the effects of mechanical environments on the biological processes of cells—has evolved from traditional biomechanics via the incorporation of strong elements of molecular and cell biology. Currently, a broad range of organ systems are being studied by surgeons, physicians, basic scientists, and engineers. These mechanobiologists aim to create new therapies and further biological understanding by quantifying the mechanical environment of cells and the molecular mechanisms of mechanically induced pathological conditions. To achieve these goals, investigators must be familiar with both the basic concepts of mechanics and the modern tools of cellular/molecular biology. Unfortunately, current literature contains numerous studies that misuse standard mechanical estimations and terminology, or fail to implement appropriate molecular analyses. Therefore, the Mechanobiology Handbook not only presents cutting-edge research findings across various fields and organ systems, but also provides the elementary chapters on mechanics and molecular analysis techniques to encourage cross-field understanding and appropriate planning. Aided by the continuous advancement of research tools in both mechanics and biology, more sophisticated experiments and analyses are possible—thus fueling the growth of the field of mechanobiology. Considering the complexity of the mechanics and the biology of the human body, most of the world of biomechanics remains to be studied. Since the field is still developing, the Mechanobiology Handbook does not force one unified theory, but brings out many different viewpoints and approaches to stimulate further research questions.

Cellular and Biomolecular Mechanics and Mechanobiology

Cellular and Biomolecular Mechanics and Mechanobiology Book
Author : Amit Gefen
Publisher : Springer
Release : 2011-02-26
ISBN : 9783642142178
Language : En, Es, Fr & De

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Book Description :

This book describes these exciting new developments, and presents experimental and computational findings that altogether describe the frontier of knowledge in cellular and biomolecular mechanics, and the biological implications, in health and disease. The book is written for bioengineers with interest in cellular mechanics, for biophysicists, biochemists, medical researchers and all other professionals with interest in how cells produce and respond to mechanical loads.

Cardiovascular Biomechanics

Cardiovascular Biomechanics Book
Author : Peter R. Hoskins,Patricia V. Lawford,Barry J. Doyle
Publisher : Springer
Release : 2017-02-16
ISBN : 3319464078
Language : En, Es, Fr & De

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Book Description :

This book provides a balanced presentation of the fundamental principles of cardiovascular biomechanics research, as well as its valuable clinical applications. Pursuing an integrated approach at the interface of the life sciences, physics and engineering, it also includes extensive images to explain the concepts discussed. With a focus on explaining the underlying principles, this book examines the physiology and mechanics of circulation, mechanobiology and the biomechanics of different components of the cardiovascular system, in-vivo techniques, in-vitro techniques, and the medical applications of this research. Written for undergraduate and postgraduate students and including sample problems at the end of each chapter, this interdisciplinary text provides an essential introduction to the topic. It is also an ideal reference text for researchers and clinical practitioners, and will benefit a wide range of students and researchers including engineers, physicists, biologists and clinicians who are interested in the area of cardiovascular biomechanics.

Phylogenomic Approaches to Deal with Particularly Challenging Plant Lineages

Phylogenomic Approaches to Deal with Particularly Challenging Plant Lineages Book
Author : Marcial Escudero,Gonzalo Nieto Feliner,Lisa Pokorny,Daniel Spalink,Juan Viruel
Publisher : Frontiers Media SA
Release : 2021-01-08
ISBN : 2889663671
Language : En, Es, Fr & De

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Book Description :

Download Phylogenomic Approaches to Deal with Particularly Challenging Plant Lineages book written by Marcial Escudero,Gonzalo Nieto Feliner,Lisa Pokorny,Daniel Spalink,Juan Viruel, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Mechanobiology

Mechanobiology Book
Author : Simon C. F. Rawlinson
Publisher : John Wiley & Sons
Release : 2017-01-31
ISBN : 1118966163
Language : En, Es, Fr & De

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Book Description :

An emerging field at the interface of biology and engineering, mechanobiology explores the mechanisms by which cells sense and respond to mechanical signals—and holds great promise in one day unravelling the mysteries of cellular and extracellular matrix mechanics to cure a broad range of diseases. Mechanobiology: Exploitation for Medical Benefit presents a comprehensive overview of principles of mechanobiology, highlighting the extent to which biological tissues are exposed to the mechanical environment, demonstrating the importance of the mechanical environment in living systems, and critically reviewing the latest experimental procedures in this emerging field. Featuring contributions from several top experts in the field, chapters begin with an introduction to fundamental mechanobiological principles; and then proceed to explore the relationship of this extensive force in nature to tissues of musculoskeletal systems, heart and lung vasculature, the kidney glomerulus, and cutaneous tissues. Examples of some current experimental models are presented conveying relevant aspects of mechanobiology, highlighting emerging trends and promising avenues of research in the development of innovative therapies. Timely and important, Mechanobiology: Exploitation for Medical Benefit offers illuminating insights into an emerging field that has the potential to revolutionise our comprehension of appropriate cell biology and the future of biomedical research.

The Science Etiology and Mechanobiology of Diabetes and its Complications

The Science  Etiology and Mechanobiology of Diabetes and its Complications Book
Author : Amit Gefen
Publisher : Academic Press
Release : 2021-04-21
ISBN : 0128210710
Language : En, Es, Fr & De

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Book Description :

The Science, Etiology and Mechanobiology of Diabetes and Its Complications presents the most comprehensive synthesis of contemporary global research on diabetes, covering a novel and unique mechanobiological perspective – addressing prevention, management and treatment of tissue, organ and body system damage associated with diabetes and its complications. The book provides a unique approach to communicating diabetes-associated symptoms and opens avenues for development of novel therapeutic and preventive methods. It offers descriptive pathophysiology of diabetes and its complications with great emphasis on mechanobiology. Content coverage also includes management of tissue, organ and body system damage caused by chronic hyperglycemia. Biologists, life scientists, physicians, pharmacists, biomedical engineers, medical physicists, biomathematicians and computer scientists who are interested in the state-of-science and current challenges in the mechanobiology of diabetes should find this book very useful. Likewise, medical researchers in fields such as endocrinology, cardiovascular medicine, oncology, obesity, the immune system, inflammation and wound care and others who wish to be updated about the latest achievements in this exciting arena of research will find that information here. Covers the state-of-knowledge in diabetes research from a mechanobiological perspective, including cell death and (neural, connective, adipose, vascular, renal etc.) tissue damage cascades and healing processes Describes state-of-the-art technology in prevention, diagnosis, prognosis and treatment of tissue, organ and body system damage caused by chronic hyperglycemia and diabetes Explores emerging research directions and future technology trends in the field of diabetes prevention and care, including common complications of diabetes (foot ulcers and amputation, peripheral neuropathy, retinal damage, renal damage, vascular and cardiac damage, connective tissue damage etc.) at the early stage of research and development in academia and industry

Mechanobiology Handbook Second Edition

Mechanobiology Handbook  Second Edition Book
Author : Jiro Nagatomi,Eno Essien Ebong
Publisher : CRC Press
Release : 2018-12-07
ISBN : 0429816731
Language : En, Es, Fr & De

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Book Description :

This will be a substantial revision of a former reference work that willl now be developed as a primary text for emerging courses in mechanobiology/cell mechanics being offered in a growing number of biomedical engineering and chemical engineering departments worldwide. It will also serve as a professional reference book for engineers, scientisits and clinicians who are interested in mechanobiology, which is the study of the effects of mechanical environments on the biological processess of cells. The readers will gain a comprehensive review of recent research findings as well as elementary chapters on solid mechanics, fluide mechanics, and molecular analysis techniques.

Textbook on Scar Management

Textbook on Scar Management Book
Author : Luc Téot,Thomas A. Mustoe,Esther Middelkoop,Gerd G. Gauglitz
Publisher : Springer Nature
Release : 2020-12-07
ISBN : 3030447669
Language : En, Es, Fr & De

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Book Description :

This text book is open access under a CC BY 4.0 license. Written by a group of international experts in the field and the result of over ten years of collaboration, it allows students and readers to gain to gain a detailed understanding of scar and wound treatment – a topic still dispersed among various disciplines. The content is divided into three parts for easy reference. The first part focuses on the fundamentals of scar management, including assessment and evaluation procedures, classification, tools for accurate measurement of all scar-related elements (volume density, color, vascularization), descriptions of the different evaluation scales. It also features chapters on the best practices in electronic-file storage for clinical reevaluation and telemedicine procedures for safe remote evaluation. The second section offers a comprehensive review of treatment and evidence-based technologies, presenting a consensus of the various available guidelines (silicone, surgery, chemical injections, mechanical tools for scar stabilization, lasers). The third part evaluates the full range of emerging technologies offered to physicians as alternative or complementary solutions for wound healing (mechanical, chemical, anti-proliferation). Textbook on Scar Management will appeal to trainees, fellows, residents and physicians dealing with scar management in plastic surgery, dermatology, surgery and oncology, as well as to nurses and general practitioners

Mechanobiology of Cell Cell and Cell Matrix Interactions

Mechanobiology of Cell Cell and Cell Matrix Interactions Book
Author : A. Wagoner Johnson,Brendan Harley
Publisher : Springer Science & Business Media
Release : 2011-02-21
ISBN : 1441980830
Language : En, Es, Fr & De

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Book Description :

Mechanobiology of Cell-Matrix Interactions focuses on characterization and modeling of interactions between cells and their local extracellular environment, exploring how these interactions may mediate cell behavior. Studies of cell-matrix interactions rely on integrating engineering, (molecular and cellular) biology, and imaging disciplines. Recent advances in the field have begun to unravel our understanding of how cells gather information from their surrounding environment, and how they interrogate such information during the cell fate decision making process. Topics include adhesive and integrin-ligand interactions; extracellular influences on cell biology and behavior; cooperative mechanisms of cell-cell and cell-matrix interactions; the mechanobiology of pathological processes; (multi-scale) modeling approaches to describe the complexity or cell-matrix interactions; and quantitative methods required for such experimental and modeling studies.

Principles of Regenerative Medicine

Principles of Regenerative Medicine Book
Author : Anthony Atala,Robert Lanza,Tony Mikos,Robert Nerem
Publisher : Academic Press
Release : 2018-08-09
ISBN : 0128098937
Language : En, Es, Fr & De

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Book Description :

Principles of Regenerative Medicine, Third Edition, details the technologies and advances applied in recent years to strategies for healing and generating tissue. Contributions from a stellar cast of researchers cover the biological and molecular basis of regenerative medicine, highlighting stem cells, wound healing and cell and tissue development. Advances in cell and tissue therapy, including replacement of tissues and organs damaged by disease and previously untreatable conditions, such as diabetes, heart disease, liver disease and renal failure are also incorporated to provide a view to the future and framework for additional studies. Comprehensively covers the interdisciplinary field of regenerative medicine with contributions from leaders in tissue engineering, cell and developmental biology, biomaterials sciences, nanotechnology, physics, chemistry, bioengineering and surgery Includes new chapters devoted to iPS cells and other alternative sources for generating stem cells as written by the scientists who made the breakthroughs Edited by a world-renowned team to present a complete story of the development and promise of regenerative medicine

Mechanobiology

Mechanobiology Book
Author : J. F. Stoltz
Publisher : IOS Press
Release : 2008
ISBN : 9781586039271
Language : En, Es, Fr & De

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Book Description :

This book covers the proceedings of the Fifth Symposium on Mechanobiology of Cartilage and Chondrocyte. Mechanobiology can be now considered as a vigorous branch of biomechanics, biorheology and physiology mainly concerned with the study of the influence of mechanical forces on cells and tissues and their clinical or therapeutical applications. As we are now in the age of proteomics, genomics and cell micro mechanical approaches, suing methods like laser tweezers or confocal microscopy, mechanobiology brings new challenges. With such new research, mechanobiology promises new diagnostic and therapeutic approaches. In other respect there has been increasing interest over recent years in the fundamental role played by local mechanical parameters in chondrocyte regulations and cartilage dysfunctions as a first step in the development of osteoarthritis. These proceedings are sub-divided into four parts: Theoretical approaches and mechanobiology of chondrocyte; Cartilage and chondrocyte studies; Osteoarthritis: inflammation degradation and clinical approaches; and, Cartilage engineering

Modern Mechanobiology

Modern Mechanobiology Book
Author : Juhyun Lee,Sharon Gerecht,Hanjoong Jo,Tzung Hsiai
Publisher : CRC Press
Release : 2021-02-25
ISBN : 1000020924
Language : En, Es, Fr & De

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Book Description :

Modern mechanobiology converges both engineering and medicine to address personalized medicine. This book is built on the previously well-received edition, Hemodynamics and Mechanobiology of Endothelium. The central theme is "omic" approaches to mechanosignal transduction underlying tissue development, injury, and repair. A cadre of investigators has contributed to the chapters, enriching the interface between mechanobiology and precision medicine for personalized diagnosis and intervention. The book begins with the fundamental basis of vascular disease in response to hemodynamic shear stress and then details cardiovascular development and regeneration, valvular and cardiac morphogenesis, mechanosensitive microRNA and histone unfolding, computational fluid dynamics, and light-sheet imaging. This edition represents a paradigm shift from traditional biomechanics and signal transduction to transgenic models, including novel zebrafish and chick embryos, and targets a wider readership from academia to industry and government agencies in the field of mechanobiology.

Introduction to Cell Mechanics and Mechanobiology

Introduction to Cell Mechanics and Mechanobiology Book
Author : Christopher R. Jacobs,Hayden Huang,Ronald Y. Kwon
Publisher : Garland Pub
Release : 2013
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

"Introduction to Cell Mechanics and Mechanobiology teaches advanced undergraduate students a quantitative understanding of the way cells detect, modify, and respond to the physical properties within the cell environment. Coverage includes the mechanics of single molecule polymers, polymer networks, two-dimensional membranes, whole-cell mechanics, and mechanobiology, as well as primer chapters on solid, fluid, and statistical mechanics"--Provided by publisher.

Cartilage Injury of the Knee

Cartilage Injury of the Knee Book
Author : Aaron J. Krych,Leela C. Biant,Andreas H. Gomoll,João Espregueira-Mendes,Alberto Gobbi,Norimasa Nakamura
Publisher : Springer Nature
Release : 2021
ISBN : 3030780511
Language : En, Es, Fr & De

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Book Description :

Cartilage injuries of the knee are common, and diagnosis and treatment options have continued to evolve. This book focuses on current non-operative and surgical treatment strategies for articular cartilage injuries, highlighting the controversies and different approaches from an international perspective. This book includes information on the basic science of cartilage structure and function, expert perspectives on imaging and diagnosing, as well as work-up of athletes and patients presenting with acute or chronic cartilage injury. It also provides an evidence base for current cutting-edge cartilage repair and restoration. Written by leading experts in the field, the book, published in collaboration with ISAKOS and ICRS, is vital reading for orthopaedic and sports medicine surgeons, fellows and residents. It is also of interest to sports trainers, physiotherapists, medical students, postgraduate students, and physical medicine and rehabilitation specialists.