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Mechanisms Of Cell Death And Opportunities For Therapeutic Development

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Mechanisms of Cell Death and Opportunities for Therapeutic Development

Mechanisms of Cell Death and Opportunities for Therapeutic Development Book
Author : Diaqing Liao
Publisher : Academic Press
Release : 2021-10-26
ISBN : 012814209X
Language : En, Es, Fr & De

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Book Description :

Mechanisms of Cell Death and Opportunities for Therapeutic Development, volume four in the Perspectives in Translational Cell Biology series, offers content for professors, students and researchers across basic and translational biology. The book covers fundamental mechanisms, ranging from different forms of cell death and drug development, to efforts for treating disease, providing a valuable resource for readers interested in understanding cell death and relevant translational research. The book's editor, Diaqing Liao, has over twenty years’ experience teaching topics of cell death. Provides a comprehensive overview of current knowledge on the process of apoptosis, its potential role in health and disease, and a discussion of potential alternative forms, such as autophagy Covers fundamental mechanisms and relevant translational research

Clinical Perspectives and Targeted Therapies in Apoptosis

Clinical Perspectives and Targeted Therapies in Apoptosis Book
Author : Rupinder K. Sodhi,Jitender Madan
Publisher : Academic Press
Release : 2020-10-15
ISBN : 0128157631
Language : En, Es, Fr & De

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Book Description :

Clinical Perspectives and Targeted Therapies in Apoptosis: Drug Discovery, Drug Delivery, and Disease Prevention provides comprehensive coverage, from basic cell biology, to modern assessment techniques for apoptosis in all major disease areas. Chapters provide an introduction to the fundamentals of cell biology, biochemical mechanisms, and the pathophysiological consequences of apoptosis. In addition, the book covers the tools and techniques used to quantify apoptosis and the significance of apoptosis in drug discovery, drug delivery, and its applications in disease prevention. Finally, the book provides a comprehensive compilation of the apoptosis targeting drugs that recently underwent clinical trials. This combination of fundamentals, along with applications in drug discovery, drug delivery, and clinical research make this book a useful resource for those in both academia and industry who are engaged in pharmaceutical, biomedical and biotechnology research. Offers standard and innovative therapeutic approaches to modulate apoptosis in clinical interventions, such as cardiovascular diseases, immune disorders, cancer chemotherapy and neurological ailments Covers cutting-edge laboratory techniques and traditional protocols to determine apoptosis, both in vitro and in vivo Examines clinical study reports of new drug moieties that are explored for various pathological conditions associated with apoptosis

Mechanisms of Cell Death

Mechanisms of Cell Death Book
Author : Cell Death Society
Publisher : Unknown
Release : 1999
ISBN : 9781573312400
Language : En, Es, Fr & De

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Book Description :

As the body of research on apoptosis grows, it paradoxically becomes simpler as the principles that define the field become more flexible and inclusive. Discussions of the role of cell death in AIDS, inflammatory disease, lung and cardiac disease, and lupus each emphasize the importance of understanding and regulating inflammation and the production of apoptotic bodies. Included in these proceedings is an in-depth review of the role of death cell genes, including intriguing studies of the existence of inhibitors of apoptosis in embryos. Many of these researchers now feel it is a combination, rather than any single gene, that activates apoptosis.

Regulated Cell Death Part A

Regulated Cell Death Part A Book
Author : Avi Ashkenazi,Junying Yuan,Jim Wells
Publisher : Elsevier
Release : 2014-06-25
ISBN : 0124171753
Language : En, Es, Fr & De

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Book Description :

Regulated Cell Death Part A & Part B of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in apoptosis focusing on the important areas of intrinsic pathway, extrinsic pathway, caspases, cellular assays and post-apoptotic effects and model organisms; as well as topics on necroptosis and screening approaches. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers research methods in biomineralization science Regulated Cell Death Part A & Part B contains sections on such topics as apoptosis focusing on the important areas of intrinsic pathway, extrinsic pathway, caspases, cellular assays and post-apoptotic effects and model organisms; as well as topics on necroptosis and screening approaches

Fifth Interdiciplinary Conference on Mechanisms of Cell Death and Disease

Fifth Interdiciplinary Conference on Mechanisms of Cell Death and Disease Book
Author : Anonim
Publisher : Unknown
Release : 2004
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Fifth Interdiciplinary Conference on Mechanisms of Cell Death and Disease book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Sixth Euroconference on Mechanisms of Cell Death and Disease

Sixth     Euroconference on Mechanisms of Cell Death and Disease Book
Author : Anonim
Publisher : Unknown
Release : 2006
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Sixth Euroconference on Mechanisms of Cell Death and Disease book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Regulated Cell Death Part B

Regulated Cell Death Part B Book
Author : Anonim
Publisher : Academic Press
Release : 2014-07-24
ISBN : 0128016191
Language : En, Es, Fr & De

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Book Description :

Regulated Cell Death Part A & Part B of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in apoptosis focusing on the important areas of intrinsic pathway, extrinsic pathway, caspases, cellular assays and post-apoptotic effects and model organisms; as well as topics on necroptosis and screening approaches. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers research methods in biomineralization science Regulated Cell Death Part A & Part B contains sections on such topics as apoptosis focusing on the important areas of intrinsic pathway, extrinsic pathway, caspases, cellular assays and post-apoptotic effects and model organisms; as well as topics on necroptosis and screening approaches

Cell Death

Cell Death Book
Author : Douglas R. Green
Publisher : Unknown
Release : 2018-09-30
ISBN : 9781621822141
Language : En, Es, Fr & De

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Book Description :

One million cells in our bodies die every second--they commit suicide by a mechanism known as apoptosis. Apoptosis is essential for survival of the body as a whole and has critical roles in various developmental processes and the immune system. In Cell Death, Douglas Green provides a clear and comprehensive view of apoptosis and other cell death mechanisms. Taking a bottom-up approach, he starts with the enzymes that perform the execution process (a family of proteases termed caspases) and examines their cellular targets and the ways in which they are activated. He then looks at the molecular machinery that links signals that cause cell death to caspases, emphasizing the importance of the BCL-2 family of proteins and the role of cytochrome c released from mitochondria. The final stage of the process, phagocytic removal of dead or dying cells, is also covered. Green outlines the roles of apoptosis and death mechanisms such as necrosis in embryogenesis, neuronal selection, and the development of self-tolerance in the immune system. In addition, he explains how cell death defends the body against cancer and traces the evolutionary origins of the apoptosis machinery back over a billion years. This new edition contains critical new information on recent exciting advances in the field, such as new forms for cell death and important insights into the mechanisms and control of apoptosis. The book is thus of great use to all biologists interested in how cells function in the context of multicellular organisms and will appeal to everyone from undergraduates encountering the topic for the first time to researchers actively working in the field.

Death Receptors in Cancer Therapy

Death Receptors in Cancer Therapy Book
Author : Wafik S. El-Deiry
Publisher : Springer Science & Business Media
Release : 2007-11-15
ISBN : 159259851X
Language : En, Es, Fr & De

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Book Description :

An in depth review of our latest understanding of the molecular events that regulate cell death and those molecules that provide targets for developing agonists or antagonists to modulate death signaling for therapeutic purposes. The authors focus on the extrinsic system of death receptors, their regulation and function, and their abnormalities in cancer. Topics of particular interest include resistance to apoptosis, TRAIL signaling, death receptors in embryonic development, mechanisms of caspase activation, and death receptor mutations in cancer. Additional chapters address death signaling in melanoma, synthetic retinoids and death receptors, the role of p53 in death receptor regulation, immune suppression of cancer, and combination therapy with death ligands.

Apoptosis and Cancer

Apoptosis and Cancer Book
Author : Seamus J. Martin
Publisher : S Karger Ag
Release : 1997-01-01
ISBN : 9783805565790
Language : En, Es, Fr & De

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Book Description :

Apoptosis and Cancer is an up-to-date overview of our understanding of apoptosis and how it effects cancer development and cancer treatment. Written by leading researchers in the field of apoptosis, this book provides an extremely valuable reference for those already familiar with apoptosis as well as a jumping-off point for those new to the field. It will appeal to scientists interested in mechanisms of cell transformation that lead to cancer and to oncologists interested in investigating and understanding new cancer therapies.

Proteasome Inhibitors in Cancer Therapy

Proteasome Inhibitors in Cancer Therapy Book
Author : Julian Adams
Publisher : Springer Science & Business Media
Release : 2004-05-25
ISBN : 1592597947
Language : En, Es, Fr & De

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Book Description :

A panel of leading academic and pharmaceutical investigators takes stock of the remarkable work that has been accomplished to date with proteasome inhibitors in cancer, and examines emerging therapeutic possibilities. The topics range from a discussion of the chemistry and cell biology of the proteasome and the rationale for proteasome inhibitors in cancer to a review of current clinical trials underway. The discussion of rationales for testing proteasome inhibitors in cancer models covers the role of the proteasome in NF-kB activation, the combining of conventional chemotherapy and radiation with proteasome inhibition, notably PS-341, new proteasome methods of inhibiting viral maturation, and the role of protesome inhibition in the treatment of AIDS. The authors also document the development of bortezomib (VelcadeTM) in Phase I clinical trials and in a multicentered Phase II clinical trials in patients with relapsed and refractory myeloma.

Cell Survival and Cell Death

Cell Survival and Cell Death Book
Author : Eric H. Baehrecke,Sally Kornbloth,Douglas R. Green,Guy Salvesen
Publisher : Much-in-Little
Release : 2013
ISBN : 9781936113316
Language : En, Es, Fr & De

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Book Description :

Billions of cells die every day in the human body. This is required for normal development and physiology, as well as the elimination of errant cells. Apoptosis and other cell death mechanisms are complex and carefully controlled. If cell death does not occur when it should, cancer and other diseases may develop. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers all aspects of apoptosis, autophagy, and necrosis. Contributors describe in detail the molecular mechanisms of cell death signaling, including death receptor-ligand systems, BCL-2 family proteins, mitochondrial permeabilization, the endocytic pathway, caspases, and signals that trigger the clearance of dying cells. Survival mechanisms and proteins such as IAPs that antagonize cell death are also described. This volume includes discussion of tumor suppression, the altered metabolism of cancer cells, and the development of therapeutic drugs. It is an essential reference for cell and developmental biologists, cancer biologists, and all who want to understand when and how cell death is required for life.

Apoptosis in Cancer Pathogenesis and Anti cancer Therapy

Apoptosis in Cancer Pathogenesis and Anti cancer Therapy Book
Author : Christopher D. Gregory
Publisher : Springer
Release : 2016-08-24
ISBN : 3319394061
Language : En, Es, Fr & De

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Book Description :

This book discusses properties of apoptosis and other cell death modalities in cancer pathogenesis and treatment. Its nine chapters discuss modulation of anti-tumor inflammatory and immune responses, effects on the tumor microenvironment, to strategies for improving pro-apoptotic therapies, mechanisms and implications for disease pathogenesis, axl and mer receptor tyrosine kinases, immunogenic apoptotic cell death and anti-cancer immunity and cancer cell death-inducing radiotherapy. This book places the onco-biology of apoptosis in clear and objective perspective through an expertly synthesized series of reviews. Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy is a deft and thorough exploration of cutting-edge research in apoptosis and anti-cancer mechanisms from basic biology to oncology. It highlights a rapidly growing field within cancer research and is essential reading for oncologists, biochemists and advanced graduate students alike.

Cell Death Signaling in Cancer Biology and Treatment

Cell Death Signaling in Cancer Biology and Treatment Book
Author : Daniel Johnson
Publisher : Springer Science & Business Media
Release : 2012-11-19
ISBN : 1461458471
Language : En, Es, Fr & De

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Book Description :

A key goal in the treatment of cancer is to achieve selective and efficient killing of tumor cells. The aim of Cell Death Signaling in Cancer Biology and Treatment is to describe state-of-the-art approaches and future opportunities for achieving this goal by targeting mechanisms and pathways that regulate cancer cell death. In this book, molecular defects in cell death signaling that characterize cancer cells, including dysregulation of cell death due to overexpression/hyperactivation of oncoproteins, as well as the loss of tumor suppressor proteins will be described. The potential for targeting microRNAs will be discussed. Multiple chapters will describe preclinical and clinical approaches that are currently being used to target epigenetic modifications, DNA repair pathways, and protein chaperones, as a means of provoking tumor cell death. Finally, the development and application of novel agents and approaches for targeting specific components of cell death signaling pathways and machinery will be reviewed.

Regulation and Dysfunction of Apoptosis

Regulation and Dysfunction of Apoptosis Book
Author : Yusuf Tutar
Publisher : BoD – Books on Demand
Release : 2022-04-06
ISBN : 183969193X
Language : En, Es, Fr & De

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Book Description :

The book provides a comprehensive review of apoptotic cell death. It discusses the mechanism of apoptosis and emerging principles of drug resistance in cancer. The development of novel drug targets and drug delivery systems for inhibiting or inducing apoptosis are the ultimate goal. Further, upregulation of anti-apoptotic proteins and loss of pro-apoptotic proteins strongly favors apoptosis evasion. The ability of cancer cells to evade apoptosis is critical for the progression and clonal expansion of malignantly transformed cells. Defective apoptosis imparts proliferative advantage to cancer cells or cells with the potential to become cancerous. The mechanisms employed by cancer cells to evade apoptosis can be used in the strategic design of therapeutic regimens aimed at exploiting apoptotic signaling networks to ensure tumor-specific cell death. This book presents knowledge of the molecular mechanisms of defective apoptosis that could be translated into the development of novel therapeutic agents and therapeutic modalities for cancer treatment.

Cell Survival and Cell Death Second Edition

Cell Survival and Cell Death  Second Edition Book
Author : Kim Newton,James Murphy,Edward Miao
Publisher : Unknown
Release : 2020-03-13
ISBN : 9781621823551
Language : En, Es, Fr & De

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Book Description :

Cell death plays a critical role in development, normal physiology, and many diseases, including cancer. This new edition on the subject provides a state-of-the-art summary of our understanding of the signaling mechanisms that regulate cell survival and cell death, along with the molecular mechanisms underlying the various different death processes seen in cells. Topics covered in this essential volume include: - Phagocyte Responses to Cell Death in Flies - Targeting Death Receptors in Cancer and Inflammation - Cell Death and Neurodegeneration - Neutrophil Extracellular Traps in Host Defense

Lysosomes

Lysosomes Book
Author : Frederick R. Maxfield,James M. Willard,Shuyan Lu
Publisher : John Wiley & Sons
Release : 2016-05-31
ISBN : 1118978307
Language : En, Es, Fr & De

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Book Description :

Discussing recent findings, up-to-date research, and novel strategies, the book integrates perspectives from pharmacology, toxicology, and biochemistry to illustrate the potential of lysosomes in drug discovery and development. • Explores basic principles and properties of lysosomes that allow them to act as regulators of cell metabolism, therapeutic targets, and sites for activation of drug conjugates • Discusses the role of lysosomes in metabolism, drug targeting, apoptosis, cancer, aging, inflammation, autophagy, metabolism, toxicity, and membrane repair • Introduces new pathways in therapeutic development and new mechanisms in drug development

Programmed Cell Death

Programmed Cell Death Book
Author : Hala Gali-Muhtasib,Omar Nasser Rahal
Publisher : BoD – Books on Demand
Release : 2020-01-15
ISBN : 1789847486
Language : En, Es, Fr & De

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Book Description :

This book incorporates developments in our understanding of cell death mechanisms and highlights recent advances in programmed cell death regulation processes. It provides the reader with the network of pathways targeted by herbal anticancer drugs and discusses the role of endoplasmic reticulum stress in cell death mechanisms in addition to highlighting the mechanisms of autophagy and its role in diseases. This book provides valuable material for researchers and for teaching postgraduate students. Emphasis on recent advances and their clinical applications offers insights to researchers that will likely lead to the development of novel therapeutic approaches.

Necrotic Cell Death

Necrotic Cell Death Book
Author : Han-Ming Shen,Peter Vandenabeele
Publisher : Springer Science & Business Media
Release : 2014-03-29
ISBN : 1461482208
Language : En, Es, Fr & De

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Book Description :

Starting with discussion of basic concepts and the molecular mechanisms of necrosis, this book looks first at several forms of necrotic cell death that have been identified, including necroptosis, autophagic cell death, and PARP-mediated cell death. As necrotic cell death is increasingly known to play a critical role in many physiological processes, the next chapters discuss its effect on metabolism, inflammation, immunity, and development. Necrotic cell death is closely implicated in human diseases like cancer, so the next chapters examine its relevance to human diseases, and final chapters cover methodologies for measuring necrosis. This book presents comprehensive coverage of necrosis from recognized experts from leading academic and medical institutions around the world. ​In contrast to apoptosis, well-defined as a form of programmed cell death, necrosis used to be considered as accidental (i.e., non-programmed) cell death, usually in response to a severe injury. Accumulating evidence now suggests, however, that necrosis is also programmed and controlled by distinctive "death machinery" in response to various stimuli like oxidative stress or DNA damage.