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Mechanisms Of Cell Death And Opportunities For Therapeutic Development

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Apoptotis Pharmacological Implications and Therapeutic Opportunities

Apoptotis  Pharmacological Implications and Therapeutic Opportunities Book
Author : N.A
Publisher : Academic Press
Release : 1997-07-23
ISBN : 0080581331
Language : En, Es, Fr & De

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Book Description :

Programmed cell death (PCD) has become a topic of widespread interest and experimentation over the past decade. Written by experts in the field, Apoptosis: Pharmacological Implications and Therapeutic Opportunities concentrates on presenting an overview of PCD pathways as they are currently understood, and strives to identify important unanswered questions as well as other therapeutic possibilities suggested by recent biochemical discoveries. Understanding the biochemical pathways that participate in the cell death process has become an important goal in developmental biology, neurobiology, cardiology, and infectious disease research. The control of apoptosis has also become a major area of investigation in the field of cancer biology. Apoptosis: Pharmacological Implications and Therapeutic Opportunities contains an overview for those with a general interest in apoptosis, and provides discussions of sufficient depth to be useful for specialists in the field.

Cell Death Signaling in Cancer Biology and Treatment

Cell Death Signaling in Cancer Biology and Treatment Book
Author : Daniel Johnson
Publisher : Springer Science & Business Media
Release : 2012-11-19
ISBN : 1461458471
Language : En, Es, Fr & De

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Book Description :

A key goal in the treatment of cancer is to achieve selective and efficient killing of tumor cells. The aim of Cell Death Signaling in Cancer Biology and Treatment is to describe state-of-the-art approaches and future opportunities for achieving this goal by targeting mechanisms and pathways that regulate cancer cell death. In this book, molecular defects in cell death signaling that characterize cancer cells, including dysregulation of cell death due to overexpression/hyperactivation of oncoproteins, as well as the loss of tumor suppressor proteins will be described. The potential for targeting microRNAs will be discussed. Multiple chapters will describe preclinical and clinical approaches that are currently being used to target epigenetic modifications, DNA repair pathways, and protein chaperones, as a means of provoking tumor cell death. Finally, the development and application of novel agents and approaches for targeting specific components of cell death signaling pathways and machinery will be reviewed.

Death Receptors in Cancer Therapy

Death Receptors in Cancer Therapy Book
Author : Wafik S. El-Deiry
Publisher : Springer Science & Business Media
Release : 2007-11-15
ISBN : 159259851X
Language : En, Es, Fr & De

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Book Description :

An in depth review of our latest understanding of the molecular events that regulate cell death and those molecules that provide targets for developing agonists or antagonists to modulate death signaling for therapeutic purposes. The authors focus on the extrinsic system of death receptors, their regulation and function, and their abnormalities in cancer. Topics of particular interest include resistance to apoptosis, TRAIL signaling, death receptors in embryonic development, mechanisms of caspase activation, and death receptor mutations in cancer. Additional chapters address death signaling in melanoma, synthetic retinoids and death receptors, the role of p53 in death receptor regulation, immune suppression of cancer, and combination therapy with death ligands.

Apoptosis and Beyond 2 Volume Set

Apoptosis and Beyond  2 Volume Set Book
Author : James A. Radosevich
Publisher : Wiley-Blackwell
Release : 2018-12-18
ISBN : 1119432421
Language : En, Es, Fr & De

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Book Description :

These volumes teach readers to think beyond apoptosis and describes all of the known processes that cells can undergo which result in cell death This two-volume source on how cells dies is the first, comprehensive collection to cover all of the known processes that cells undergo when they die. It is also the only one of its kind to compare these processes. It seeks to enlighten those in the field about these many processes and to stimulate their thinking at looking at these pathways when their research system does not show signs of activation of the classic apoptotic pathway. In addition, it links activities like the molecular biology of one process (eg. Necrosis) to another process (eg. apoptosis) and contrasts those that are close to each. Volume 1 of Apoptosis and Beyond: The Many Ways Cells Die begins with a general view of the cytoplasmic and nuclear features of apoptosis. It then goes on to offer chapters on targeting the cell death mechanism; microbial programmed cell death; autophagy; cell injury, adaptation, and necrosis; necroptosis; ferroptosis; anoikis; pyronecrosis; and more. Volume 2 covers such subjects as phenoptosis; pyroptosis; hematopoiesis and eryptosis; cyclophilin d-dependent necrosis; and the role of phospholipase in cell death. Covers all known processes that dying cells undergo Provides extensive coverage of a topic not fully covered before Offers chapters written by top researchers in the field Provides activities that link and contrast processes to each other Apoptosis and Beyond: The Many Ways Cells Die will appeal to students and researchers/clinicians in cell biology, molecular biology, oncology, and tumor biology.

Animal Models of Molecular Pathology

Animal Models of Molecular Pathology Book
Author : P. Michael Conn
Publisher : Academic Press
Release : 2012
ISBN : 0123945968
Language : En, Es, Fr & De

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Book Description :

This volume explores some of the most exciting recent advances in basic research on animal models of molecular pathology. This series provides a forum for discussion of new discoveries, approaches, and ideas Contributions from leading scholars and industry experts Reference guide for researchers involved in molecular biology and related fields

Programmed Cell Death in Cancer Progression and Therapy

Programmed Cell Death in Cancer Progression and Therapy Book
Author : Roya Khosravi-Far,Eileen White
Publisher : Springer Science & Business Media
Release : 2007-12-29
ISBN : 9781402065545
Language : En, Es, Fr & De

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Book Description :

Programmed cell death (PCD) plays pivotal roles in tumor progression, cancer therapeutics and resistance of tumor cells to therapy. This book examines the mechanisms involved in mediating and regulating PCD in cancer. It also provides a detailed indication of the utility of PCD in cancer therapy. The book features chapters on the current and future of RNA interference in therapeutics and Pathways involved in Stem Cell Survival and Death.

Apoptosis in Normal Development and Cancer

Apoptosis in Normal Development and Cancer Book
Author : M Sluyser
Publisher : CRC Press
Release : 2002-09-11
ISBN : 0203483154
Language : En, Es, Fr & De

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Book Description :

In apoptosis in the mammalian system, cells have a finite life - they develop, are used and then die. Cancer cells escape this programmed routine but, from an understanding of apoptosis, they can be programmed to die. This book addresses the

Apoptotic Pathways as Targets for Novel Therapies in Cancer and Other Diseases

Apoptotic Pathways as Targets for Novel Therapies in Cancer and Other Diseases Book
Author : Marek Los,Spencer B. Gibson
Publisher : Springer Science & Business Media
Release : 2006-06-20
ISBN : 0387236953
Language : En, Es, Fr & De

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Book Description :

As our understanding of apoptotic pathway expands, we are coming to realize the great potential of utilizing this pathway to treat diseases such as cancer. The book attempts to review, summarize, and speculate on the apoptotic pathways, how are they regulated and how targeted therapies are being used to treat a wide variety of diseases. Special emphasis is placed on cancer since new treatments either being developed or currently in the clinical setting are showing great promise to increase survival rates for cancer patients. Chapters will address the biology behind regulating the apoptotic pathways and what goes wrong in disease states whereas other chapters will concentrate on new therapies targeting apoptotic pathways. The reader by the end of the book should have greater insight into the understanding and utilization of apoptotic pathways to fight diseases such as cancer.

Cell Death

Cell Death Book
Author : Hao Wu
Publisher : Springer Science & Business Media
Release : 2013-11-19
ISBN : 1461493021
Language : En, Es, Fr & De

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Book Description :

Beginning from centuries of anecdotal descriptions of cell death, such as those on the development of the midwife toad in 1842 by Carl Vogt, to modern-day investigations of cell death as a biological discipline, it has become accepted that cell death in multicellular organisms is a normal part of life. This book provides a comprehensive view of cell death, from its mechanisms of initiation and execution, to its implication in human disease and therapy. Physiological cell death plays critical roles in almost all aspects of biology, and the book details its roles in lymphocyte homeostasis, neuronal function, metabolism, and the DNA damage response. When physiological cell death goes awry, diseases can arise, and cancer is presented as a central paradigm for the consequences of derangements in the interplay between cell survival and cell death. At the same time, the potential promise of targeted therapies aimed at interdicting cell death machineries are also discussed extensively. The molecular mechanisms that underlie apoptotic cell death are illustrated from the perspectives of both the intrinsic, mitochondrial apoptotic pathway and the extrinsic, death receptor pathway. Key players in these pathways, such as the Bcl2 family proteins, cytochrome c, Apaf-1, caspases, death receptor adapter proteins, and inhibitor of apoptosis proteins, are presented from both functional and structural angles. Until only a few years ago, programmed cell death has been considered essentially synonymous with apoptosis. However, we now know that programmed cell death can also take other forms such as necrosis or necroptosis, and to this end, the mechanisms that underlie programmed necrosis in development and host defense are illustrated. The past twenty plus years have seen an incredible growth of research in cell death, with one breakthrough after another, and the legacy still goes on with constant new surprises and findings. Long live cell death!

Comprehensive Toxicology

Comprehensive Toxicology Book
Author : N.A
Publisher : Elsevier
Release : 2017-12-01
ISBN : 0081006128
Language : En, Es, Fr & De

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Book Description :

Comprehensive Toxicology, Third Edition, discusses chemical effects on biological systems, with a focus on understanding the mechanisms by which chemicals induce adverse health effects. Organized by organ system, this comprehensive reference work addresses the toxicological effects of chemicals on the immune system, the hematopoietic system, cardiovascular system, respiratory system, hepatic toxicology, renal toxicology, gastrointestinal toxicology, reproductive and endocrine toxicology, neuro and behavioral toxicology, developmental toxicology and carcinogenesis, also including critical sections that cover the general principles of toxicology, cellular and molecular toxicology, biotransformation and toxicology testing and evaluation. Each section is examined in state-of-the-art chapters written by domain experts, providing key information to support the investigations of researchers across the medical, veterinary, food, environment and chemical research industries, and national and international regulatory agencies. Thoroughly revised and expanded to 15 volumes that include the latest advances in research, and uniquely organized by organ system for ease of reference and diagnosis, this new edition is an essential reference for researchers of toxicology. Organized to cover both the fundamental principles of toxicology and unique aspects of major organ systems Thoroughly revised to include the latest advances in the toxicological effects of chemicals on the immune system Features additional coverage throughout and a new volume on toxicology of the hematopoietic system Presents in-depth, comprehensive coverage from an international author base of domain experts

Cell Cycle Mechanisms and Neuronal Cell Death

Cell Cycle Mechanisms and Neuronal Cell Death Book
Author : Agata Copani,Ferdinando Nicoletti
Publisher : Springer Science & Business Media
Release : 2007-03-06
ISBN : 0387293906
Language : En, Es, Fr & De

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Book Description :

Cell-Cycle Mechanisms and Neuronal Cell Death examines the role of cell cycle activation in the molecular mechanisms leading to neuronal degeneration. Leading Authors discuss this topic in relation to the major neurological disorders, including Alzheimer’s disease, stroke and epilepsy. This book serves to gain new insights into the molecular determinants of neuronal death and to establish new targets for therapeutic intervention.

Abeloff s Clinical Oncology E Book

Abeloff s Clinical Oncology E Book Book
Author : John E. Niederhuber,James O. Armitage,James H Doroshow,Michael B. Kastan,Joel E. Tepper
Publisher : Elsevier Health Sciences
Release : 2013-09-12
ISBN : 1455728810
Language : En, Es, Fr & De

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Book Description :

Practical and clinically focused, Abeloff’s Clinical Oncology is a trusted medical reference book designed to capture the latest scientific discoveries and their implications for cancer diagnosis and management of cancer in the most accessible manner possible. Abeloff’s equips everyone involved - from radiologists and oncologists to surgeons and nurses - to collaborate effectively and provide the best possible cancer care. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Select the most appropriate tests and imaging studies for cancer diagnosis and staging of each type of cancer, and manage your patients in the most effective way possible by using all of the latest techniques and approaches in oncology. Enhance your understanding of complex concepts with a color art program that highlights key points and illustrates relevant scientific and clinical problems. Stay at the forefront of the latest developments in cancer pharmacology, oncology and healthcare policy, survivorship in cancer, and many other timely topics. See how the most recent cancer research applies to practice through an increased emphasis on the relevance of new scientific discoveries and modalities within disease chapters. Streamline clinical decision making with abundant new treatment and diagnostic algorithms as well as concrete management recommendations. Take advantage of the collective wisdom of preeminent multidisciplinary experts in the field of oncology, including previous Abeloff’s editors John E. Niederhuber, James O. Armitage, and Michael B. Kastan as well as new editors James H. Doroshow from the National Cancer Institute and Joel E. Tepper of Gunderson & Tepper: Clinical Radiation Oncology. Quickly and effortlessly access the key information you need with the help of an even more user-friendly, streamlined format. Access the complete contents anytime, anywhere at Expert Consult, and test your mastery of the latest knowledge with 500 online multiple-choice review questions.

Programmed Cell Death in Protozoa

Programmed Cell Death in Protozoa Book
Author : Jose Perez-Martin
Publisher : Springer Science & Business Media
Release : 2008-12-10
ISBN : 9780387767178
Language : En, Es, Fr & De

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Book Description :

Under the name of programmed cell death (PCD) are included diverse molecular mechanisms of cell suicide which play an essential role in the development of multicellular organisms. The best known PCD mechanism in multicellular organisms is called apoptosis. However, recent studies indicate that PCD is also present in protozoa and unicellular eukaryotes. The eleven chapters of this book give the reader a comprehensive update of the progress in the understanding of the mechanisms of PCD in protozoa. The chapters have been written by experts in this field of research and are arranged following an evolutionary point of view.

Artificial Cells Cell Engineering and Therapy

Artificial Cells  Cell Engineering and Therapy Book
Author : S Prakash
Publisher : Woodhead Publishing
Release : 2007-06-14
ISBN : 9781845690366
Language : En, Es, Fr & De

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Book Description :

Artificial cells, cell engineering and therapy are emerging technologies which will make a significant impact on the future of medicine and healthcare. However, research within the field is vast. This unique book provides a comprehensive study of the most recent advances in the field and its practical applications. The first part of the book offers the reader an introduction to the basics of artificial cell technology with chapters on its origins, design, current status within medicine and future prospects. Part two covers apoptosis, the use of bone marrow stromal cells in myocardial regeneration together with signalling and tissue engineering. Part three discusses artificial cells for therapy, procedures for various clinical conditions and the current status of the discipline within the field. The book concludes with a final section on the role of artificial cells in medicine with particular focus on the use of artificial cells as blood substitutes and their potential use in myocardial regeneration, drug delivery and in treating kidney and bowel diseases, diabetes and cancer. Artificial cells, cell engineering and therapy is a valuable reference for researchers, students and practitioners within the field. Introduces the basics of artificial cell technology Provides a comprehensive study of the most recent advances in artificial cells, cell engineering and cell therapy Discusses the design, engineering and uses of artificial cells

Apoptosis in Health and Disease

Apoptosis in Health and Disease Book
Author : Martin Holcik,Eric C. LaCasse,Alex E. MacKenzie
Publisher : Cambridge University Press
Release : 2012-01-26
ISBN : 052115944X
Language : En, Es, Fr & De

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Book Description :

A 2005 survey of the role of apoptosis in the pathogenesis of many significant human illnesses and injury states.

Programmed Cell Death

Programmed Cell Death Book
Author : Hala Gali-Muhtasib,Omar Nasser Rahal
Publisher : BoD – Books on Demand
Release : 2020-01-15
ISBN : 1789847486
Language : En, Es, Fr & De

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Book Description :

This book incorporates developments in our understanding of cell death mechanisms and highlights recent advances in programmed cell death regulation processes. It provides the reader with the network of pathways targeted by herbal anticancer drugs and discusses the role of endoplasmic reticulum stress in cell death mechanisms in addition to highlighting the mechanisms of autophagy and its role in diseases. This book provides valuable material for researchers and for teaching postgraduate students. Emphasis on recent advances and their clinical applications offers insights to researchers that will likely lead to the development of novel therapeutic approaches.

Progress in Clinical Neurosciences

Progress in Clinical Neurosciences Book
Author : Vedantam Rajshekhar
Publisher : Byword Books Private Limited
Release : 2008-09-11
ISBN : 8181930320
Language : En, Es, Fr & De

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Book Description :

This volume of Progress in Clinical Neurosciences comprises review articles on various aspects of movement disorders and cerebrovascular diseases in Neurology, and vascular surgery and neuro-oncology in Neurosurgery. Besides these, there are chapters on the Consumer Protection Act, normal pressure hydro-cephalus and miscellaneous topics. The authors of these chapters are well recognized for their work and the exhaustive review of the literature contained in the chapters will benefit not only postgraduate students but will also update the knowledge of practising clinicians.

Apoptosis Senescence and Cancer

Apoptosis  Senescence and Cancer Book
Author : David A. Gewirtz,Shawn E. Holt,Steven Grant
Publisher : Springer Science & Business Media
Release : 2007-12-17
ISBN : 1588295273
Language : En, Es, Fr & De

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Book Description :

Provides insight into established practices and research into apoptosis and senescence by examining techniques and research in the fields of cell death pathways, senescence growth arrest, drugs and resistance, DNA damage response, and other topics which still hold mysteries for researchers. This book concludes with established cancer therapies.

Nasopharyngeal Carcinoma

Nasopharyngeal Carcinoma Book
Author : Pierre Busson
Publisher : Springer Science & Business Media
Release : 2013-03-12
ISBN : 1461459478
Language : En, Es, Fr & De

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Book Description :

This volume intends to contribute to “translational medicine and biology”. By this, we mean a bi-directional process whose aim is to develop knowledge from basic science towards diagnostic and therapeutic applications and reciprocally to raise new questions for basic scientists. One general requirement for translational research is to establish a multidisciplinary knowledge base shared by the actors of various specialties. This is precisely the aim of the 12 chapters of this book. It will be useful for scientists, including PhD students, who want to become more familiar with the main concepts of NPC pathology, medical imaging and current therapeutics. Conversely, medical doctors who want to update their knowledge of NPC biology will benefit from chapters on viral and cellular oncogenesis and various aspects of host-tumor interactions.

Cancer Principles Practice of Oncology

Cancer  Principles   Practice of Oncology Book
Author : Vincent T. DeVita,Theodore S. Lawrence,Steven A. Rosenberg
Publisher : Lippincott Williams & Wilkins
Release : 2012-03-28
ISBN : 1451156006
Language : En, Es, Fr & De

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Book Description :

Drawn from the content of the new Ninth Edition of Cancer: Principles and Practice of Oncology, this unique publication brings together the basic scientific information on the molecular biology of cancer. The format is designed to be useful both to research scientists interested in the study of cancer and to oncologists who need to understand these new developments that are having a profound impact on the care of patients with cancer. Leading scientists and clinicians in the field of molecular biology and clinical oncology have lent their expertise to this project. The text has been divided into two parts. Part I includes thirteen chapters that deal with the general principles of the molecular biology of cancer that provide the basic framework for an understanding of the behavior of cancer cells. Part II includes an up-to-date description of how this new information has affected the understanding of the biology of 19 of the most common cancers, with an emphasis on how these new findings have been translated to impact the management of cancer patients. This distinctive text provides a single concise source of information for scientists and clinicians in this rapidly developing field