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Mathematical Approaches To Liver Transplantation

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Mathematical Approaches to Liver Transplantation

Mathematical Approaches to Liver Transplantation Book
Author : Eduardo Massad,Eleazar Chaib
Publisher : Academic Press
Release : 2020-03-20
ISBN : 0128174374
Language : En, Es, Fr & De

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Book Description :

Mathematical Approaches to Liver Transplantation provides mathematical approaches to the optimization of liver graft distribution. Through mathematical and computational methods, several aspects related to organ allocation are tackled, with possible solutions presented. The book discusses topics such as patient selection for liver transplantation, transplantation procedures, dynamics of organs waiting list, improvement on grafts allocation, live donors and MELD scale. The content focuses on liver transplantation, however the mathematical approaches presented can be successfully replicated to different organs. This book is a valuable source for mathematical biologists, bioinformaticians, and several members of biomedical field who are involved in decision-making related to organs transplantation. Provides a mathematical approach to the optimization of liver grafts distribution Presents mathematical and computational methods for several aspects relating to organ allocations and discusses possible solutions Encompasses optimization models for the best organ distribution strategy to support decision-makers that are responsible for liver and other organ transplantation policies

Redesigning Liver Allocation Regions Through Optimization

Redesigning Liver Allocation Regions Through Optimization Book
Author : Timothy Edward Scully
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

End-stage liver disease is one of the leading causes of death in the United States, and the only viable treatment is liver transplantation. Since the quality of a donor liver decreases with transportation time, United States organ policy prioritizes transplants within geographic regions. However, the boundaries of these regions were defined mostly by informal relationships between transplant centers many decades ago, which has created local imbalances in supply and demand. As a result, candidates on the waiting list for donor livers face drastically different odds of receiving a transplant. Policy makers have noticed this geographic inequity and are considering proposals for alternative liver allocation approaches. This thesis uses mathematical optimization to redesign liver allocation regions by modeling and including several key elements of the allocation process directly in the optimization formulation. Specifically, we use a fluid approximation to model the dynamics of the wait-list progression and liver allocation. The model is fit using historical data of wait-list candidates and donors. Then, we propose two optimization formulations to reduce geographic inequality. The first directly minimizes the variation in median level of illness at the time of transplant across geographical areas, which is a key metric used by policy makers in addressing geographic inequality. The second approach minimizes the liver transport distance, subject to a certain allowable level of geographic variation. We discuss how these models can flexibly incorporate additional policy constraints to create more realistic models to reduce geographic variation. The region configurations are evaluated on key metrics relating to fairness and system efficiency using a standardized, validated, simulation approach widely accepted by policymakers. Finally, we propose a region design that significantly reduces geographic inequality without any substantial impact on the system's efficiency.

Bioartificial Livers

Bioartificial Livers Book
Author : Adam James Davidson
Publisher : Unknown
Release : 2011
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

In this work, a mathematical modelling approach is taken to improve and optimize the designs of bioartificial liver (BAL) systems. BALs are an alternative therapy for the extremely serious condition of liver failure where liver transplant is currently the only viable option. As yet, large-scale clinical trials have not been successful enough in order for BALs to gain regulatory approval. Through the work in this report, it is envisaged that BAL design can be improved to the point where they can gain clinical acceptance. One of the main issues in BAL design is the provision of adequate oxygen to the cell mass. To this end, a mathematical model to describe oxygen mass transport is developed based on the principle of Krogh cylinders. The results of this model are subsequently interpreted and presented in Operating Region charts, an image of a parameter space that corresponds to viable BAL designs. These charts allow several important design trends to be identified, e.g. numerous short and thin hollow fibres are favourable over fewer thicker, longer fibres. In addition, it is shown that a physiologically relevant cell number of more than 10% of the native liver cell mass can be supported in these devices under the right conditions. Subsequently the concept of the Operating Region is expanded to include zonation, a metabolic phenomenon where local oxygen tension is a primary modulator of liver cell function. It is found that zonation profiles can be well controlled and under standard conditions a plasma flow rate of 185 ml/min to the BAL would distribute the three metabolic zones evenly. Finally, the principles of the Operating Region charts and zonation are applied to three existing commercial BAL designs; the HepaMate, BLSS and ELAD systems. In each case it could be seen that the default designs of each system did not present ideal environments for liver cells. Through consideration of zonation profiles, each device design and operating parameters could be optimized to produce in vivo-like environments. In the case of the ELAD, reducing the plasma flow rate from 500 to 90 ml/min resulted in a balanced zonation profile. Overall, the work in this report has developed and detailed a series of tools that will assist a BAL designer in making judicious choices over bioreactor design and operating parameters. As a result, it is hoped that BALs can take a step forward towards clinical practice and ultimately saving lives.

Transplant International Official Journal of the European Society for Organ Transplantation

Transplant International Official Journal of the European Society for Organ Transplantation Book
Author : G. Opelz,W.A. Buurman,J.P. van Hooff,P. MacMaster,J. Wallwork
Publisher : Springer Science & Business Media
Release : 2013-11-11
ISBN : 3642774237
Language : En, Es, Fr & De

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Book Description :

This supplement to Transplant International contains the Proceedings of the successful 5th Congress of the European Society for Organ Transplantation held in Maastricht from 7-10 October 1991. Of 827 abstracts submitted to the congress, 548 were selected by the Scien tific Committee for either oral or poster presentation. Of these 548 presenta tions, the guest editors selected 212 full papers for publication in this book. Two aspects are important where proceedings are concerned-the quality of the papers and the speed of publication. I thank our authors and guest editors, whose combined expertise has given us a guarantee of quality. I also thank our editorial and production teams for their tremendous efforts to hasten editing, proofreading, printing, and publication. In particular, I would like to express my gratitude to Maurits Booster, M.D., and Sylvia van Roosmalen for their assist ance and support in seeing this supplement through to completion. As a concession to time, we have waived some of our stringent rules of style and limited our correspondence with authors by, for example, page proofs being reviewed and corrected in house only. This enables us to publish two months earlier but has the disadvantage that, given the allotted time, we have not been able to ensure that each and every article has an abstract, nor that every "i" has been dotted in the reference lists or in the addresses/institute affiliations of all the authors.

Mathematical Methods in Survival Analysis Reliability and Quality of Life

Mathematical Methods in Survival Analysis  Reliability and Quality of Life Book
Author : Catherine Huber,Nikolaos Limnios,Mounir Mesbah,Mikhail S. Nikulin
Publisher : John Wiley & Sons
Release : 2013-03-01
ISBN : 1118624114
Language : En, Es, Fr & De

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Book Description :

Reliability and survival analysis are important applications of stochastic mathematics (probability, statistics and stochastic processes) that are usually covered separately in spite of the similarity of the involved mathematical theory. This title aims to redress this situation: it includes 21 chapters divided into four parts: Survival analysis, Reliability, Quality of life, and Related topics. Many of these chapters were presented at the European Seminar on Mathematical Methods for Survival Analysis, Reliability and Quality of Life in 2006.

Tissue Engineering I

Tissue Engineering I Book
Author : Kyongbum Lee,David Kaplan
Publisher : Springer Science & Business Media
Release : 2006-10-16
ISBN : 3540319441
Language : En, Es, Fr & De

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Book Description :

This book covers trends in modern biotechnology. All aspects of this interdisciplinary technology, where knowledge, methods and expertise are required from Chemistry, Biochemistry, Microbiology, Genetics, Chemical Engineering and Computer Science, are treated. More information as well as the electronic version available at springeronline.com

Proceedings of the International Conference on Health Care Systems Engineering

Proceedings of the International Conference on Health Care Systems Engineering Book
Author : Andrea Matta,Jingshan Li,Evren Sahin,Ettore Lanzarone,John Fowler
Publisher : Springer Science & Business Media
Release : 2013-11-20
ISBN : 3319018485
Language : En, Es, Fr & De

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Book Description :

The International Conference on Health Care Systems Engineering (HCSE) provided a timely opportunity to discuss statistical analysis and operations management issues in health care delivery systems. The conference took place in Milan between May 22nd and 24th, 2013. Scientists and practitioners discussed new ideas, methods and technologies for improving the operation of health care organizations. The event and this resulting volume emphasize research in the field of health care systems engineering developed in close collaboration with clinicians.​ Topics applicable to researchers and practitioners include: hospital drug logistics, operating theatres, modelling and simulation in patient care and healthcare organizations, home care services.

BIOMAT 2013

BIOMAT 2013 Book
Author : Rubem P Mondaini
Publisher : World Scientific
Release : 2014-03-18
ISBN : 981460223X
Language : En, Es, Fr & De

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Book Description :

This is a book of a series on interdisciplinary topics on the Biological and Mathematical Sciences. The chapters correspond to selected papers on special research themes, which have been presented at BIOMAT 2013 International Symposium on Mathematical and Computational Biology which was held in the Fields Institute for Research in Mathematical Sciences, Toronto, Ontario, Canada, on November 04 – 08, 2013. The treatment is both pedagogical and advanced in order to motivate research students as well as to fulfill the requirements of professional practitioners. There are comprehensive reviews written by prominent scientific leaders of famous research groups. Contents:Population Dynamics:The Princess and the Pea: The Unexpected Importance of Movement Algorithms (Rebecca Tyson)Plankton Nutrient Interaction Model with Harvesting under Constant Environment (Samares Pal and A Chatterjee)Traveling Wave Solutions for a Chemotaxis System (F Catrina and V M Reyes G)Dynamics of a General Stage Structured N Parallel Food Chains (Isam Al-Darabsah and Yuan Yuan)Pattern Recognition of Biological Phenomena:Complex Data Clustering: From Neural Network Architecture to Theory and Applications of Nonlinear Dynamics of Pattern Recognition (Guojun Gan, Jialun Yin, Yulia Wang and Jianhong Wu)Dynamic and Geometric Modelling of Biomolecular Structures:A Two-Step Kinetic Model of Insulin Aggregation with a Competitive Inhibitor (Mark Whidden, Allison Ho and Santiago Schnell)Optimal Control Techniques in Mathematical Modelling of Biological Phenomena:Optimal Control of Resource Coefficient in a Parabolic Population Model (J Bintz, H Finotti and S Lenhart)Optimization of Costs for Combating Aedes Aegypti in Optimal Time-Windows (W O Dias, G A Xavier, D A P Lima, E F Wanner and R T N Cardoso)Dynamics of a Varroa-Infested Honey Bee Colonies Model (K O Okosun)Computational Biology:Probability Distributions of GC Content Reflect the Evolution of Primate Species (Marco V José, Qi Lu and Juan R Bobadilla)Mining the Constraints of Protein Evolution (Fernando Encinas and Antonio Basilio de Miranda)Entropy Measures Based Methods for the Classification of Protein Domains into Families and Clans (Nicolas Carels, Cecilia F Mondaini and Rubem P Mondaini)Modelling Physiological Disorders:Modelling of Porous Elastic and Viscoelastic Media and Its Application to the Brain (R Begg, J Murley, M. Kohandel and S Sivaloganathan)The Mathematics of Liver Transplantation (F A B Coutinho, E Chaib, M Amaku, M M Burattini and E Massad)Complexity of Molecular Signaling Networks for Various Types of Cancer and Neurological Diseases Correlates with Patient Survivability (D Breitkreutz, E A Rietman, P Hinow, M Healey and J A Tuszynski)Mathematical Modelling of Infectious Diseases:Modelling Malaria Dynamics in Temperate Regions with Long Term Incubation Period (Kyeongah Nah, Gergely Röst and Yongkuk Kim)A Simulation of the U S Influenza Outbreak in 2009–2010 Using a Patch SIR Model based on Airport Transportation Data (D L Wallace and M Chen)Modelling Directly Transmitted Infections considering Age-structured Contact Rate and Vaccination (H M Yang and C H Dezotti)A General Framework for Agent-Based Modelling with Applications to Infectious Disease Dynamics (Marek Laskowski and Seyed M Moghadas)Analysis of the Basic Reproduction Number from the Initial Growth Phase of the Outbreak in Diseases Caused by Vectors (R P Sanches and E Massad)Parameter Estimation of a Tuberculosis Model in a Patchy Environment: Case of Cameroon (D P Moualeu, S Bowong and J Kürts)An Agent-Based Modelling Framework for Tuberculosis Infection with Drug-Resistance (Aquino L Espindola, A S Martinez and Seyed M Moghadas)Some Extensions of the Classical Epidemic Models (Fred Brauer) Readership: Undergraduates, graduates, researchers and all practitioners on the interdisciplinary fields of Mathematical Biology, Biological Physics and Mathematical Modelling of Biosystems. Keywords:Mathematical Biology;Biomathematics;Mathematical Modelling of Biosystems;Biological Physics;Biophysics;Computational Biology;Bioinformatics

14th Nordic Baltic Conference on Biomedical Engineering and Medical Physics

14th Nordic Baltic Conference on Biomedical Engineering and Medical Physics Book
Author : Alexei Katashev,Yuri Dekhtyar,Janis Spigulis
Publisher : Springer Science & Business Media
Release : 2008-07-30
ISBN : 354069367X
Language : En, Es, Fr & De

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Book Description :

14th Nordic – Baltic Conference on Biomedical Engineering and Medical Physics – NBC-2008 – brought together scientists not only from the Nordic – Baltic region, but from the entire world. This volume presents the Proceedings of this international conference, jointly organized by the Latvian Medical Engineering and Physics Society, Riga Technical University and University of Latvia in close cooperation with International Federation of Medical and Biological Engineering (IFMBE) The topics covered by the Conference Proceedings include: Biomaterials and Tissue Engineering; Biomechanics, Artificial Organs, Implants and Rehabilitation; Biomedical Instrumentation and Measurements, Biosensors and Transducers; Biomedical Optics and Lasers; Healthcare Management, Education and Training; Information Technology to Health; Medical Imaging, Telemedicine and E-Health; Medical Physics; Micro- and Nanoobjects, Nanostructured Systems, Biophysics

Healthcare Analytics

Healthcare Analytics Book
Author : Hui Yang,Eva K. Lee
Publisher : John Wiley & Sons
Release : 2016-10-13
ISBN : 1119374642
Language : En, Es, Fr & De

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Book Description :

Features of statistical and operational research methods and tools being used to improve the healthcare industry With a focus on cutting-edge approaches to the quickly growing field of healthcare, Healthcare Analytics: From Data to Knowledge to Healthcare Improvement provides an integrated and comprehensive treatment on recent research advancements in data-driven healthcare analytics in an effort to provide more personalized and smarter healthcare services. Emphasizing data and healthcare analytics from an operational management and statistical perspective, the book details how analytical methods and tools can be utilized to enhance healthcare quality and operational efficiency. Organized into two main sections, Part I features biomedical and health informatics and specifically addresses the analytics of genomic and proteomic data; physiological signals from patient-monitoring systems; data uncertainty in clinical laboratory tests; predictive modeling; disease modeling for sepsis; and the design of cyber infrastructures for early prediction of epidemic events. Part II focuses on healthcare delivery systems, including system advances for transforming clinic workflow and patient care; macro analysis of patient flow distribution; intensive care units; primary care; demand and resource allocation; mathematical models for predicting patient readmission and postoperative outcome; physician–patient interactions; insurance claims; and the role of social media in healthcare. Healthcare Analytics: From Data to Knowledge to Healthcare Improvement also features: • Contributions from well-known international experts who shed light on new approaches in this growing area • Discussions on contemporary methods and techniques to address the handling of rich and large-scale healthcare data as well as the overall optimization of healthcare system operations • Numerous real-world examples and case studies that emphasize the vast potential of statistical and operational research tools and techniques to address the big data environment within the healthcare industry • Plentiful applications that showcase analytical methods and tools tailored for successful healthcare systems modeling and improvement The book is an ideal reference for academics and practitioners in operations research, management science, applied mathematics, statistics, business, industrial and systems engineering, healthcare systems, and economics. Healthcare Analytics: From Data to Knowledge to Healthcare Improvement is also appropriate for graduate-level courses typically offered within operations research, industrial engineering, business, and public health departments.

Mathematics Unlimited 2001 and Beyond

Mathematics Unlimited   2001 and Beyond Book
Author : Björn Engquist,Wilfried Schmid
Publisher : Springer
Release : 2017-04-05
ISBN : 364256478X
Language : En, Es, Fr & De

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Book Description :

This is a book guaranteed to delight the reader. It not only depicts the state of mathematics at the end of the century, but is also full of remarkable insights into its future de- velopment as we enter a new millennium. True to its title, the book extends beyond the spectrum of mathematics to in- clude contributions from other related sciences. You will enjoy reading the many stimulating contributions and gain insights into the astounding progress of mathematics and the perspectives for its future. One of the editors, Björn Eng- quist, is a world-renowned researcher in computational sci- ence and engineering. The second editor, Wilfried Schmid, is a distinguished mathematician at Harvard University. Likewi- se the authors are all foremost mathematicians and scien- tists, and their biographies and photographs appear at the end of the book. Unique in both form and content, this is a "must-read" for every mathematician and scientist and, in particular, for graduates still choosing their specialty. Limited collector's edition - an exclusive and timeless work. This special, numbered edition will be available until June 1, 2000. Firm orders only.

Mathematics Everywhere

Mathematics Everywhere Book
Author : Martin Aigner,Ehrhard Behrends
Publisher : American Mathematical Soc.
Release : 2010
ISBN : 0821843494
Language : En, Es, Fr & De

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Book Description :

Mathematics is all around us. Often we do not realize it, though. Mathematics Everywhere is a collection of presentations on the role of mathematics in everyday life, through science, technology, and culture. The common theme is the unique position of mathematics as the art of pure thought and at the same time as a universally applicable science. The authors are renowned mathematicians; their presentations cover a wide range of topics. From compact discs to the stock exchange, from computer tomography to traffic routing, from electronic money to climate change, they make the ``math inside'' understandable and enjoyable. An additional attractive feature is the leisurely treatment of some hot topics that have gained prominence in recent years, such as Fermat's Theorem, Kepler's packing problem, and the solution of the Poincare Conjecture. Or maybe you have heard about the Nash equilibrium (of ``A Beautiful Mind'' fame), or the strange future of quantum computers, and want to know what it is all about? Well, open the book and take an up-to-date trip into the fascinating world of the mathematics all around us.

Perspective in Image Guided Surgery

Perspective in Image Guided Surgery Book
Author : Anonim
Publisher : Unknown
Release : 2022-01-24
ISBN : 9814482498
Language : En, Es, Fr & De

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Book Description :

Download Perspective in Image Guided Surgery book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Liver Pathophysiology

Liver Pathophysiology Book
Author : Pablo Muriel
Publisher : Academic Press
Release : 2017-03-02
ISBN : 0128043210
Language : En, Es, Fr & De

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Book Description :

Liver Pathophysiology: Therapies and Antioxidants is a complete volume on morphology, physiology, biochemistry, molecular biology and treatment of liver diseases. It uses an integral approach towards the role of free radicals in the pathogenesis of hepatic injury, and how their deleterious effects may be abrogated by the use of antioxidants. Written by the most prominent authors in the field, this book will be of use to basic and clinical scientists and clinicians working in the biological sciences, especially those dedicated to the study and treatment of liver pathologies. Presents the most recent advances in hepatology, with a special focus on the role of oxidative stress in liver injury. Provides in vivo and in vitro models to study human liver pathology. Explains the beneficial effects of antioxidants on liver diseases. Contains the most recent and modern treatments of hepatic pathologies, including, but not limited to, stem cells repopulation, gene therapy and liver transplantation.

Systems Biology and Bioinformatics in Gastroenterology and Hepatology

Systems Biology and Bioinformatics in Gastroenterology and Hepatology Book
Author : Steven Dooley,Kai Breuhahn,Andreas Teufel
Publisher : Frontiers Media SA
Release : 2020-01-03
ISBN : 2889633497
Language : En, Es, Fr & De

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Book Description :

Download Systems Biology and Bioinformatics in Gastroenterology and Hepatology book written by Steven Dooley,Kai Breuhahn,Andreas Teufel, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Translational Research Methods in Diabetes Obesity and Nonalcoholic Fatty Liver Disease

Translational Research Methods in Diabetes  Obesity  and Nonalcoholic Fatty Liver Disease Book
Author : Andrew J. Krentz,Christian Weyer,Marcus Hompesch
Publisher : Springer
Release : 2019-04-02
ISBN : 3030117480
Language : En, Es, Fr & De

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Book Description :

This book aims to aid the selection of the most appropriate methods for use in early phase (1 and 2) clinical studies of new drugs for diabetes, obesity, non-alcoholic fatty liver disease (NAFLD) and related cardiometabolic disorders. Clinical research methods to assess the pharmacokinetics and pharmacodynamics of new diabetes drugs, e.g. the euglycemic clamp technique, have become well-established in proof-of-mechanism studies. However, selection of the most appropriate techniques is by no means straightforward. Moreover, the application of such methods must conform to the regulatory requirements for new drugs. This book discusses the need for new pharmacotherapies for diabetes, obesity and NAFLD and the molecular targets of drugs currently in development. Emerging technologies including functional imaging, circulating biomarkers and omics are considered together with practical and ethical issues pertaining to early phase clinical trials in subjects with cardiometabolic disorders. Translational Research Methods in Diabetes, Obesity, and Non-Alcoholic Fatty Liver Disease is of interest to biomedical scientists, pharmacologists, academics involved in metabolic research and clinicians practicing in these specialties.

Diabetes Literature Index

Diabetes Literature Index Book
Author : Anonim
Publisher : Unknown
Release : 1976
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Diabetes Literature Index book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Assessing Medical Technologies

Assessing Medical Technologies Book
Author : Institute of Medicine,Division of Health Promotion and Disease Prevention,Division of Health Sciences Policy,Committee for Evaluating Medical Technologies in Clinical Use
Publisher : National Academies Press
Release : 1985-02-01
ISBN : 030903583X
Language : En, Es, Fr & De

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Book Description :

New drugs, new devices, improved surgical techniques, and innovative diagnostic procedures and equipment emerge rapidly. But development of these technologies has outpaced evaluation of their safety, efficacy, cost-effectiveness, and ethical and social consequences. This volume, which is "strongly recommended" by The New England Journal of Medicine "to all those interested in the future of the practice of medicine," examines how new discoveries can be translated into better care, and how the current system's inefficiencies prevent effective health care delivery. In addition, the book offers detailed profiles of 20 organizations currently involved in medical technology assessment, and proposes ways to organize U.S. efforts and create a coordinated national system for evaluating new medical treatments and technology.

Biomedical Index to PHS supported Research

Biomedical Index to PHS supported Research Book
Author : Anonim
Publisher : Unknown
Release : 1994
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Biomedical Index to PHS supported Research book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

ACCCN s Critical Care Nursing

ACCCN s Critical Care Nursing Book
Author : Doug Elliott,Leanne Aitken,Wendy Chaboyer
Publisher : Elsevier Australia
Release : 2011-11-21
ISBN : 0729540685
Language : En, Es, Fr & De

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Book Description :

Provides detailed coverage of a number of specialty areas within critical care nursing including intensive care, emergency nursing, cardiac nursing, neuroscience nursing and acute care. It will encourage students to be reflective practitioners, ethical decision makers and providers of evidence based care. Australian authors.