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Lung Epithelial Biology In The Pathogenesis Of Pulmonary Disease

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Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease

Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease Book
Author : Venkataramana K Sidhaye,Michael Koval
Publisher : Academic Press
Release : 2017-03-09
ISBN : 0128038810
Language : En, Es, Fr & De

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Book Description :

Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease provides a one-stop resource capturing developments in lung epithelial biology related to basic physiology, pathophysiology, and links to human disease. The book provides access to knowledge of molecular and cellular aspects of lung homeostasis and repair, including the molecular basis of lung epithelial intercellular communication and lung epithelial channels and transporters. Also included is coverage of lung epithelial biology as it relates to fluid balance, basic ion/fluid molecular processes, and human disease. Useful to physician and clinical scientists, the contents of this book compile the important and most current findings about the role of epithelial cells in lung disease. Medical and graduate students, postdoctoral and clinical fellows, as well as clinicians interested in the mechanistic basis for lung disease will benefit from the books examination of principles of lung epithelium functions in physiological condition. Provides a single source of information on lung epithelial junctions and transporters Discusses of the role of the epithelium in lung homeostasis and disease Includes capsule summaries of main conclusions as well as highlights of future directions in the field Covers the mechanistic basis for lung disease for a range of audiences

How Tobacco Smoke Causes Disease

How Tobacco Smoke Causes Disease Book
Author : Anonim
Publisher : U.S. Government Printing Office
Release : 2010
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Targeting Cellular Signalling Pathways in Lung Diseases

Targeting Cellular Signalling Pathways in Lung Diseases Book
Author : Kamal Dua,Raimar Löbenberg,Ângela Cristina Malheiros Luzo,Shakti Shukla,Saurabh Satija
Publisher : Springer Nature
Release : 2021-07-02
ISBN : 9813368276
Language : En, Es, Fr & De

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Book Description :

The book comprehensively reviews and provides detailed insight into the cellular and molecular signalling mechanisms involved in pathophysiology of various respiratory diseases, towards developing effective therapeutic strategies in the management and treatment of lung disease. It also covers promising advances in the field of therapeutics that could lead to novel clinical therapies capable of preventing or reversing the disease features including novel strategies for targeting chronic lung diseases using advanced drug delivery systems. Importantly, the book examines the significance and relevance of the plant extracts and their constituents with therapeutic efficiencies against lung diseases. As such, the book offers a blend of translational, biological, chemical, and drug delivery aspects relevant to respiratory diseases, thus, offering a valuable resource for pulmonologists and translational researchers working in the field of pulmonary biology and respiratory medicine.

ABC of COPD

ABC of COPD Book
Author : Graeme P. Currie
Publisher : John Wiley & Sons
Release : 2010-11-04
ISBN : 9781444329483
Language : En, Es, Fr & De

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Book Description :

Chronic Obstructive Pulmonary Disease (COPD) is a progressive, largely irreversible lung condition characterised by airflow obstruction. Although cigarette smoking is the single most important risk factor in its development, other associations and risk factors are thought to have increasing relevance throughout the world. COPD is usually managed in primary care, although it is commonly under-diagnosed, and is one of the most common medical conditions necessitating admission to hospital. The second edition of the ABC of COPD provides the entire multidisciplinary team with a reliable, up-to-date and accessible account of COPD. Extensively updated by experienced clinicians - including new chapters on spirometry, inhalers, oxygen, death, dying and end of life issues - this ABC is an authoritative and practical guide for general practitioners, practice nurses, specialist nurses, medical students, paramedical staff, junior doctors, non-specialist doctors and all other health professionals working in both primary and secondary care.

Idiopathic Pulmonary Fibrosis

Idiopathic Pulmonary Fibrosis Book
Author : Joseph P. Lynch
Publisher : CRC Press
Release : 2003-12-18
ISBN : 0203913442
Language : En, Es, Fr & De

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Book Description :

A discussion of the epidemiology, clinical features, and differential diagnoses of idiopathic pulmonary fibrosis (IPF). Key topics include the role of polymorphonuclear leukocytes in the pathogenesis of pulmonary fibrosis, and current treatment options, including medical therapy and lung transplantation.

Notch Signaling in Embryology and Cancer

Notch Signaling in Embryology and Cancer Book
Author : Jörg Reichrath,Sandra Reichrath
Publisher : Springer Science & Business Media
Release : 2012-03-07
ISBN : 1461408997
Language : En, Es, Fr & De

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Book Description :

The goal of this volume is to comprehensively cover a highly readable overview on our present knowledge of the role of Notch signalling for embryology and cancer, with a focus on new findings in molecular biology. Topics that are discussed in-depth by leading researchers and clinicians range from the newest findings in cellular and molecular pathology to new concepts for prophylaxis and treatment of cancer. Experts in the field as well as scientists and health care professionals not intimately involved in these specialized areas are provided with the most significant and timely information related to these topics. It is the aim of this book to summarize essential up-to-date information for every clinician or scientist interested in the role of Notch signalling in embryology and cancer. We hope that this volume will be adopted as the standard text in this area of science and will stimulate new interest in the role of Notch signalling for embryology and cancer. We further hope that this compendium will serve as both a source for current researchers and a guide to stimulate and assist those in related disciplines to enter this exciting field of research.

Lung Stem Cells in Development Health and Disease

Lung Stem Cells in Development  Health and Disease Book
Author : Nikolic, Marko Z.,Hogan, Brigid L.M.
Publisher : European Respiratory Society
Release : 2021-04-01
ISBN : 1849841349
Language : En, Es, Fr & De

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Book Description :

Most organs in the adult human body are able to maintain themselves and undergo repair after injury; these processes are largely dependent on stem cells. In this Monograph, the Guest Editors bring together leading authors in the field to provide information about the different classes of stem cells present both in the developing and adult lung: where they are found, how they function in homeostasis and pathologic conditions, the mechanisms that regulate their behaviour, and how they may be harnessed for therapeutic purposes. The book focuses on stem cells in the mouse and human lung but also includes the ferret as an increasingly important new model organism. Chapters also discuss how lung tissue, including endogenous stem cells, can be generated in vitro from pluripotent stem cell lines. This state-of-the-art collection comprehensively covers one of the most exciting areas of respiratory science

Next generation Interstitial Lung Disease An Issue of Clinics in Chest Medicine EBook

Next generation Interstitial Lung Disease  An Issue of Clinics in Chest Medicine EBook Book
Author : Harold R Collard,Luca Richeldi,Kerri A. Johannson
Publisher : Elsevier Health Sciences
Release : 2021-06-03
ISBN : 0323757847
Language : En, Es, Fr & De

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Book Description :

In this issue of Clinics in Chest Medicine, Guest Editors Harold R Collard, Luca Richeldi, and Kerri A. Johannson bring their considerable expertise to the topic of Next-generation Interstitial Lung Disease. Provides concise and comprehensive coverage of the issues physicians face every day. Presents the latest information on a timely, focused topic under the leadership of experienced editors in the field.

The Lung

The Lung Book
Author : Ahmed El-Hashash
Publisher : Elsevier
Release : 2021-06-29
ISBN : 0128212063
Language : En, Es, Fr & De

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Book Description :

In the lung, more recent data have been accumulated on lung stem cell biology/function and the potential applications of stem cells in pulmonary diseases that are facilitated by the recent development of a broad range of cutting edge in vitro and in vivo research tools and approaches, including mouse and human organoid cultures, genetic editing in vitro and in vivo, human induced pluripotent cell (iPS cell) models of disease, haploid cells for genetic as well as compound screening paradigms, genetically engineered mice, and stem cell transplantation to cure diseases. Stem Cell Innovation in Health and Disease: Volume 2: The Lung, contains two major sections describing cutting edge research for understanding stem cell functions in the lung and respiratory system, and for developing methods to bring stem cells from bench to bedside; respectively. Each section includes insights ranging from using mouse and human organoid cultures, genetic editing in vitro and in vivo, and human induced pluripotent cells (iPSCs) to study stem cell functions and model lung diseases, through the cutting-edge research aiming to bring stem cells from bench to bedside, including the potential application of iPSCs, ESCs and blood stem cells (stem cell transplants) in the treatment of lung diseases/disorders. This book, therefore, discusses the fact-based promise of stem cells and regenerative medicine in the lung in the real world. Provides intensive scientific background and most recent information on cutting edge research to understand respiratory stem cell functions and develop methods to bring stem cells from bench to bedside for different lung diseases Analyzes the current state, opportunities, and challenges of innovative technologies and stem cells from bench to bed, including organoids and iPSC-derived alveolar epithelia cell therapy in the lung Contains two major sections describing cutting-edge research for understanding stem cell functions and for developing methods specific to the lung

Advances in Cell Based and Gene Based Therapies for Respiratory Diseases

Advances in Cell Based and Gene Based Therapies for Respiratory Diseases Book
Author : Miquéias Lopes-Pacheco,Fernanda Ferreira Cruz,Anna Dmitriyevna Krasnodembskaya,Johnatas Dutra Silva,Darcy Elizabeth Wagner
Publisher : Frontiers Media SA
Release : 2022-04-29
ISBN : 2889760456
Language : En, Es, Fr & De

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Book Description :

Prof. Wagner owns stock shares in Pfizer and Merck, patent pending on whole organ decellularisation and recelluarisation US20160067378A1. The other Topic Editors declare no competing interests with regards to the Research Topic theme.

Mustard Lung

Mustard Lung Book
Author : Mostafa Ghanei,Ali Amini Harandi
Publisher : Academic Press
Release : 2016-05-03
ISBN : 0128039795
Language : En, Es, Fr & De

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Book Description :

Mustard Lung: Diagnosis and Treatment of Respiratory Disorders in Sulfur-Mustard Injured Patients brings together the details regarding pathophysiology, medication, and protective issues to provide a comprehensive look at health problems associated with sulfur mustard injury. It provides a bench-to-bedside look at the long term complications of vesicant exposure in humans as well as how mustard gas exposure affects lung function. By providing guidelines and approaches for the diagnosis, pathogenesis, and treatment of SM injury cases, this book is helpful for a wide range of medical researchers and clinicians. For decades, chemical respiratory disorders were diagnosed and managed traditionally similar to other chronic respiratory diseases. However, the exact nature of chemical respiratory disorders is different and needs to be treated as such. Includes the most up-to-date basic and clinical research findings on sulfur mustard from top researchers Provides information on chemical agents, complications that arise due to sulfur mustard exposure, and drugs available to treat injuries Contains an appendix with practical prescription recommendations for patients affected by mustard lung Provides a bench-to-bedside look at the long term complications of vesicant exposure in humans as well as how mustard gas exposure affects lung function

Stem Cell Innovation in Health Disease The Lung Volume 2

Stem Cell Innovation in Health   Disease  The Lung  Volume 2 Book
Author : Ahmed El-Hashash
Publisher : Academic Press
Release : 2021-06-10
ISBN : 0128212071
Language : En, Es, Fr & De

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Book Description :

In the lung, more recent data have been accumulated on lung stem cell biology/function and the potential applications of stem cells in pulmonary diseases that are facilitated by the recent development of a broad range of cutting edge in vitro and in vivo research tools and approaches, including mouse and human organoid cultures, genetic editing in vitro and in vivo, human induced pluripotent cell (iPS cell) models of disease, haploid cells for genetic as well as compound screening paradigms, genetically engineered mice, and stem cell transplantation to cure diseases. Stem Cell Innovation in Health and Disease: Volume 2: The Lung, contains two major sections describing cutting edge research for understanding stem cell functions in the lung and respiratory system, and for developing methods to bring stem cells from bench to bedside; respectively. Each section includes insights ranging from using mouse and human organoid cultures, genetic editing in vitro and in vivo, and human induced pluripotent cells (iPSCs) to study stem cell functions and model lung diseases, through the cutting-edge research aiming to bring stem cells from bench to bedside, including the potential application of iPSCs, ESCs and blood stem cells (stem cell transplants) in the treatment of lung diseases/disorders. This book, therefore, discusses the fact-based promise of stem cells and regenerative medicine in the lung in the real world. Provides intensive scientific background and most recent information on cutting edge research to understand respiratory stem cell functions and develop methods to bring stem cells from bench to bedside for different lung diseases Analyzes the current state, opportunities, and challenges of innovative technologies and stem cells from bench to bed, including organoids and iPSC-derived alveolar epithelia cell therapy in the lung Contains two major sections describing cutting-edge research for understanding stem cell functions and for developing methods specific to the lung

Targeting Chronic Inflammatory Lung Diseases Using Advanced Drug Delivery Systems

Targeting Chronic Inflammatory Lung Diseases Using Advanced Drug Delivery Systems Book
Author : Kamal Dua,Philip M. Hansbro,Ridhima Wadhwa,Mehra Haghi,Lisa G. Pont,Kylie A. Williams
Publisher : Academic Press
Release : 2020-08-04
ISBN : 0128208880
Language : En, Es, Fr & De

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Book Description :

Targeting Chronic Inflammatory Lung Diseases Using Advanced Drug Delivery Systems explores the development of novel therapeutics and diagnostics to improve pulmonary disease management, looking down to the nanoscale level for an efficient system of targeting and managing respiratory disease. The book examines numerous nanoparticle-based drug systems such as nanocrystals, dendrimers, polymeric micelles, protein-based, carbon nanotube, and liposomes that can offer advantages over traditional drug delivery systems. Starting with a brief introduction on different types of nanoparticles in respiratory disease conditions, the book then focuses on current trends in disease pathology that use different in vitro and in vivo models. The comprehensive resource is designed for those new to the field and to specialized scientists and researchers involved in pulmonary research and drug development. Explores recent perspectives and challenges regarding the management and diagnosis of chronic respiratory diseases Provides insights into how advanced drug delivery systems can be effectively formulated and delivered for the management of various pulmonary diseases Includes the most recent information on diagnostic methods and treatment strategies using controlled drug delivery systems (including nanotechnology)

Cystic Fibrosis

Cystic Fibrosis Book
Author : Dennis Wat,Dilip Nazareth
Publisher : BoD – Books on Demand
Release : 2020-07-08
ISBN : 1789841453
Language : En, Es, Fr & De

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Book Description :

Cystic Fibrosis - Heterogeneity and Personalized Treatment provides the latest research and clinical evidence for clinicians, scientists and researchers involved in the care of patients with cystic fibrosis (CF). This book outlines the burden of the CF microbiome, utilisation of CF registries to impact future care, the sequelae of hepatobiliary complication, the use of upcoming technologies to provide patient-centred care, and provides an overview of cystic fibrosis transmembrane regulator (CFTR) modulators. Looking after patients with CF is highly rewarding, allowing those of us to combine our dedication and problem-solving skills to create a personalized approach. This book is invaluable for those involved in the care of CF patients.

Basic Epithelial Ion Transport Principles and Function

Basic Epithelial Ion Transport Principles and Function Book
Author : Kirk L. Hamilton,Daniel C. Devor
Publisher : Springer Nature
Release : 2020-11-26
ISBN : 3030527808
Language : En, Es, Fr & De

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Book Description :

This book discusses unique ion channels and transporters that are located within epithelial tissues of various organs including the kidney, intestine, pancreas and respiratory tract. As the authors show, these channels and transporters play crucial roles in transepithelial ion and fluid transport across epithelia and their contribution to maintaining homeostasis. Readers will be introduced to the fundamentals of ion transport in terms of function, modelling, regulation, structure and pharmacology. This is the first of three volumes highlighting the importance of epithelial ion channels and transporters in basic physiology and pathophysiology of human diseases. This volume focuses on basic fundamentals of epithelial transport physiology. There is a range of chapters dedicated to specific aspects of epithelial ion transport and cell function. Accordingly, the authors discuss techniques used to determine epithelial function, principles of epithelia transport, polarization of epithelial cells, mathematical modelling of epithelial ion transport, protein folding of ion channels, degradation epithelial ion channels, fundamentals of epithelial sodium, potassium and chloride transport, fundamentals of bicarbonate secretion, volume regulation, and microRNA regulation of epithelial channels and transporters. Given its scope, Volume 1 offers a valuable resource for physiology students, scientists and clinicians alike.

Clinical Applications of TGF Beta

Clinical Applications of TGF Beta Book
Author : Gregory Bock,Joan Marsh
Publisher : John Wiley & Son Limited
Release : 1991-05-03
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

TGF-beta, originally identified as a transforming growth factor with similar properties, is now known to exist as a family of factors with similar properties. These factors promote cell proliferation in some tissue types or conditions and induce cell differentiation in others. Features the latest information on the TGF-beta family and its receptors. Describes correlations between TGF-beta and certain cancers, including glioblastomas. Also contains reports of preliminary investigations of clinical applications for TGF-beta in many diseases, including leukemia and its use to accelerate wound healing.

Interstitial Lung Disease

Interstitial Lung Disease Book
Author : Marvin I. Schwarz,Talmadge E. King
Publisher : PMPH-USA
Release : 2003
ISBN : 1550091794
Language : En, Es, Fr & De

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Book Description :

Interstitial Lung Disease, Fourth Edition is a complete publication of interstitial lung diseases and includes clinical, pathologic, radiologic, and physiologic evaluation of the patient with ILD. It provides a basic pathobiology and a complete description of individual disease entities. The book covers a wide array of disorders - sarcoidosis, asbestosis, hypersensitivity pneumonitis, drug-induced lung disease, connective tissue disease, and pulmonary vasculitis, to name but a few. This new edition also features an examination of future potential therapies for interstitial lung disease. Interstitial Lung Disease is divided into three sections. The Clinical Approach section provides the basis for recognizing the key features that allow a specific diagnosis to be achieved. The section dedicated to Basic Mechanisms emphasizes the many advances in genetics and cellular and molecular biology that have greatly expanded our understanding of the biological processes involved in the pathogenesis of the interstitial lung diseases. The third section titled Clinical Entities describes the clinical manifestations, radiologic patterns, histopathological features, and management of the specific p

Oxidative Stress in Lung Diseases

Oxidative Stress in Lung Diseases Book
Author : Sajal Chakraborti,Tapati Chakraborti,Salil Kumar Das,Dhrubajyoti Chattopadhyay
Publisher : Springer Nature
Release : 2019-08-31
ISBN : 9811384134
Language : En, Es, Fr & De

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Book Description :

This first volume of the comprehensive, two-volume work on oxidative stress in lung disease introduces the molecular mechanisms, and the role of oxidants in the progression of different lung diseases. The lungs of humans and animals are under constant threat from oxidants from either endogenous (e.g. in situ metabolic reactions) or exogenous sources (e.g. air pollutants). Further, oxidative stress causes the oxidation of proteins, DNA and lipids, which in turn generates secondary metabolic products. The book consists of sections, each focusing on different aspects of oxidant-mediated lung diseases. As such it is a unique reference resource for postgraduate students, biomedical researchers and also for the clinicians who are interested in studying and understanding oxidant-mediated lung diseases. The second volume will incorporate other aspects of oxidant-mediated lung diseases, including prevention and therapeutics.

Optimizing New in Vitro Methodologies for Assessing the Effects of Mechanical Stimuli on Lung Cells

Optimizing New in Vitro Methodologies for Assessing the Effects of Mechanical Stimuli on Lung Cells Book
Author : Alicia E. Tanneberger
Publisher : Unknown
Release : 2021
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Chronic lung diseases affect millions of people in the United States and are a leading cause of both morbidity and mortality. Studying how environmental factors affect lung cell biology and function is being increasingly recognized as a critical step in understanding lung disease pathogenesis and the development of new therapeutic approaches that combat lung diseases. These factors include lung extracellular matrix (ECM) composition and the mechanobiological factors of stiffness and cyclic mechanical strain, which during breathing, act on cells during the normal expansion and contraction of the lung. However, current methodologies for studying these factors have significant limitations and new approaches are necessary, particularly for investigating how these factors are altered in diseased lungs. As such, the goal of this thesis was to develop and optimize new in vitro methodologies that can be used to assess the effects of these three factors (ECM composition, stiffness, and cyclic mechanical strain (stretch)) on lung cells under both normal and diseased conditions, where idiopathic pulmonary fibrosis served as the disease model. I present work from two independent sets of studies that were designed to investigate the effects of these factors individually and in combinatorial fashion. The first study focused on how stiffness and ECM composition, alone and in combination, can cause changes in a representative relevant human lung cell type, human lung fibroblasts (HLF). A novel approach utilized ECM protein (hydrogel) solutions derived from decellularized normal or diseased human lungs (composition factor) coated onto the surface of CytoSoft® stiffness specific plates (2 kPa, 8 kPa, or 16 kPa) (stiffness factor). Endpoint assessments included cell morphology, growth, metabolism, and relevant gene expression. These results demonstrate that ECM composition and substrate stiffness, both alone and in combination affect HLF behavior. In the second series of studies, the goal was to assess how cyclic mechanical stretch impact function of an important lung cell type: alveolar epithelial type II (AT2) cells, critical for surfactant production. Utilizing AT2s derived from induced pluripotent stem cells (iAT2s) as a model system, the cells underwent biaxial stretch using a FlexCell® FX-5000[trademark symbol] Tension System for either 2 or 24 hours. Endpoint assessments included imaging and gene expression compared to un-stretched cells. The results show unique morphological changes in the stretched samples, while the gene expression data prove to be more variable. Collectively, this work shows how environmental and mechanical factors, including matrix composition, stiffness, and stretch, impact lung cell function and provides optimized methods to study such interactions. The unique methodology utilized should enable further investigations into both normal physiology and lung pathologies.

Asthma and COPD

Asthma and COPD Book
Author : Peter J. Barnes,Jeffrey M. Drazen,Stephen I. Rennard
Publisher : Academic Press
Release : 2009
ISBN : 0123740010
Language : En, Es, Fr & De

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Book Description :

The Second Edition of Asthma and COPD: Basic Mechanisms and Clinical Management continues to provide a unique and authoritative comparison of asthma and COPD. Written and edited by the world's leading experts, it continues to be a comprehensive review of the most recent understanding of the basic mechanisms of both conditions, specifically comparing their etiology, pathogenesis, and treatments. Each chapter considers Asthma and COPD in side-by-side contrast and comparison - not in isolation - in the context of mechanism, triggers, assessments, therapies, and clinical management Presents the latest and most comprehensive understandings of the mechanisms of inflammation in both Asthma and COPD Most extensive reference to primary literature on both Asthma and COPD in one source. Easy-to-read summaries of the latest advances alongside clear illustrations