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Long Non Coding RNA Biology

Long Non Coding RNA Biology Book
Author : M.R.S. Rao
Publisher : Springer
Release : 2017-08-16
ISBN : 9811052034
Language : En, Es, Fr & De

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Book Description :

This contributed volume offers a comprehensive and detailed overview of the various aspects of long non-coding RNAs and discusses their emerging significance. Written by leading experts in the field, it motivates young researchers around the globe, and offers graduate and postgraduate students fascinating insights into genes and their regulation in eukaryotes and higher organisms.

Long Non Coding RNAs

Long Non Coding RNAs Book
Author : Durdica Ugarkovic
Publisher : Springer Science & Business Media
Release : 2011-02-01
ISBN : 9783642165023
Language : En, Es, Fr & De

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Book Description :

Long non-coding RNAs (lncRNAs), tentatively defined as ncRNAs of more than two hundred nucleotides in length, are characterized by the complexity and diversity of their sequences and mechanisms of action. Based on genome-wide studies, more than 3,300 of them exist, but to date only the limited number of functional lncRNAs have been identified and characterized. Nonetheless, lncRNAs have emerged as key molecules involved in the control of transcriptional and posttranscriptional gene regulatory pathways. They take part in the recruitment of chromatin modifying complexes and regulate splicing, localization, stability and translation of the target mRNAs. This book provides an overview of the rapidly advancing field of long ncRNAs, describing the epigenetic and non-epigenetic mechanisms by which they regulate various biological functions in model systems, from yeast to mammals. The role of ncRNAs in sex chromosome dosage compensation in flies and mammals is described, as well as their role in centromere and telomere biology. Long non-coding RNAs involved in environmental stress response and development are presented and their mechanisms of action discussed.

Molecular Biology of Long Non coding RNAs

Molecular Biology of Long Non coding RNAs Book
Author : Ahmad M. Khalil
Publisher : Springer
Release : 2019-07-30
ISBN : 3030170861
Language : En, Es, Fr & De

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Book Description :

This second edition shows how long non-coding RNAs (lnc)RNAs have emerged as a new paradigm in epigenetic regulation of the genome. Thousands of lncRNAs have been identified and observed in a wide range of organisms. Unlike mRNA, lncRNA have no protein-coding capacity. So, while their function is not entirely clear, they may serve as key organizers of protein complexes that allow for higher order regulatory events. Advances in the field also include better characterization of human long non-coding RNAs, novel insights into their roles in human development and disease, their diverse mechanisms of action and novel technologies to study them.

Long Non coding RNAs in Human Disease

Long Non coding RNAs in Human Disease Book
Author : Kevin V. Morris
Publisher : Springer
Release : 2016-04-13
ISBN : 3319239074
Language : En, Es, Fr & De

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Book Description :

This volume focuses on the roles of long non-coding RNAs (lncRNAs) in contexts ranging from human cancers to cardiovascular disease and ageing. The role of lncRNAs in X-inactivation and those lncRNAs derived from pseudogenes, past retroelements integrated within the human genome, as well as the role these pseudogene-derived lncRNAs play in cancer development are discussed in detail. Further, the book examines the function of lncRNAs in diseases such as diabetes, in smooth muscle formation, and in the modulation of nuclear receptors, as well as in connection with perspectives on the development of personalized therapeutics. It offers an appealing and insightful resource for scientists and clinicians alike.

The Chemical Biology of Long Noncoding RNAs

The Chemical Biology of Long Noncoding RNAs Book
Author : Stefan Jurga,Jan Barciszewski
Publisher : Springer Nature
Release : 2020-10-01
ISBN : 303044743X
Language : En, Es, Fr & De

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Book Description :

This book offers a comprehensive and detailed overview of various aspects of long non-coding RNAs. It discusses their emerging significance in molecular medicine, ranging from human cancers to cardiovascular and metabolic diseases. Transcriptomic studies have demonstrated that the majority of genomes found in complex organisms are expressed in highly dynamic and cell-specific patterns, producing huge numbers of intergenic, antisense and intronic long non-protein-coding RNAs (lncRNAs). Thousands of lncRNAs have been identified, and unlike mRNA, they have no protein-coding capacity. A large repertoire of ncRNAs, actively transcribed from the mammalian genome, control diverse cellular processes, both in terms of development and diseases, through a variety of gene regulatory mechanisms. IncRNAs have emerged as a new paradigm in epigenetic regulation of the genome. Given its scope, the book will be of particular interest to molecular, chemical, cell and developmental biologists, as well as specialists in translational medicine involved in disease-oriented research. It also offers a valuable resource for in silico experts seeking a deeper understanding of lncRNA expression and function through computational analysis of the NGS data.

Long Non Coding RNA

Long Non Coding RNA Book
Author : Syed Mudasir Ahmad,Nazir Ahmad Ganai
Publisher : Cambridge Scholars Publishing
Release : 2020-09-03
ISBN : 1527559106
Language : En, Es, Fr & De

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Book Description :

Long non-coding RNAs (LncRNAs) were originally regarded as “noise” in the genome due to their lack of protein-encoding capacity. However, their roles are now understood to cover various biological functions like gene regulation, cell proliferation, survival, differentiation, and chromatin remodeling. As an emerging group of non-coding RNA molecules, LncRNAs are involved in diverse diseases like cancer, cardiovascular, autoimmune, hormonal disorders, neurodegeneration, and infection, among others. However, knowledge of the mechanisms by which they act is still ambiguous. As such, this book meets the essential need for a textbook dedicated to this topic and provides a comprehensive and captivating account of lncRNA research.

Long Non coding RNA

Long Non coding RNA Book
Author : Antonin Morillon
Publisher : Elsevier
Release : 2018-02-01
ISBN : 0081023553
Language : En, Es, Fr & De

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Book Description :

The dark side of the genome represents vast domains of the genome that are not encoding for proteins – the basic bricks of cellular structure and metabolism. Up to 98% of the human genome is non-coding and produces so-called long non-coding RNA. Some of these non-coding RNA play fundamental roles in cellular identity, cell development and cancer progression. They are now widely studied in many organisms to understand their function. This book reviews this expanding field of research and present the broad functional diversities of those molecules and their putative fundamental and therapeutic roles and develops the recent history of non-coding RNA, their very much debated classification and how they raise a formidable interest for developmental and tumorigenesis biology. Using classical examples and an extensive bibliography, the book illustrates the most studied and attractive examples of these long non-coding RNA, how they interface with epigenetics, genome integrity and expression and what are the current models of their regulatory mechanisms. This book offers a large review about the long non-coding RNA It presents the broad functional diversities of those molecules It presents pioneer works from the field Provides a comprehensive review of the field Presents fundamental and therapeutic interests

The Long and Short Non coding RNAs in Cancer Biology

The Long and Short Non coding RNAs in Cancer Biology Book
Author : Erwei Song
Publisher : Springer
Release : 2016-07-04
ISBN : 9811014981
Language : En, Es, Fr & De

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Book Description :

The book conveys a comprehensive knowledge of long and short ncRNAs in cancer regulation and their potentials as diagnostic biomarkers and therapeutic targets. Topics covered include the molecular mechanisms of various classes of ncRNAs (with emphasis on long non-coding RNAs and microRNAs) in cancer, the functional roles of ncRNAs in regulating different cancer hallmarks (including proliferation, apoptosis, stem-cell properties, epithelial-mesenchymal transition, metabolism, angiogenesis, tumor-host interactions and therapeutic resistance), the role of ncRNAs in regulating cancer signaling circuitry programs (highlighting their involvement in c-myc, p53 and NFkB signaling), a systemic summary of clinical and preclinical studies that evaluate the potential of ncRNA signatures for cancer diagnosis and prognosis and strategies to delivery short ncRNAs as therapeutic molecules for cancer treatment. This book may serve as a comprehensive resource for researchers, graduate students and oncologists in ncRNA and cancer research and help drug development by identifying ncRNA targets.

Long Non Coding RNAs

Long Non Coding RNAs Book
Author : Yi Feng,Lin Zhang
Publisher : Humana Press
Release : 2016-01-01
ISBN : 9781493933761
Language : En, Es, Fr & De

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Book Description :

This volume assembles a broad spectrum of methods used in long non-coding RNAs (lncRNA) research, ranging from computational annotation of lncRNA genes to molecular and cellular analyses of the function of individual lncRNA. Long Non-Coding RNAs: Methods and Protocols also discusses methods used to study circular RNAs and RNA splicing, as well as influential findings on lncRNA in human diseases. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and cutting-edge, Long Non-Coding RNAs: Methods and Protocols is a must-have for molecular biologists, cell and developmental biologists, specialists who conduct disease-oriented research, and bioinformatics experts who seek a better understanding on lncRNA expression and function by computational analysis of the massive sequencing data that are rapidly accumulating in recent years.

Long Non coding RNA Sarrah Staying Young at Heart

Long Non coding RNA Sarrah  Staying Young at Heart Book
Author : Dorotée Julia Trembinski
Publisher : Unknown
Release : 2019
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Long Non coding RNA Sarrah Staying Young at Heart book written by Dorotée Julia Trembinski, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Non coding RNA and the Reproductive System

Non coding RNA and the Reproductive System Book
Author : Dagmar Wilhelm,Pascal Bernard
Publisher : Springer
Release : 2015-12-11
ISBN : 940177417X
Language : En, Es, Fr & De

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Book Description :

This book provides an overview of the role and function of regulatory RNAs that lack protein-coding potential in key reproductive tissues. This includes the role of small interfering RNAs (siRNAs), microRNAs (miRNAs), PIWI-interacting RNAs (piRNAs), small nucleolar RNAs (snoRNAs) and long non-coding RNAs (lncRNAs). Through clear, detailed and comprehensive debate, international leading experts discuss the role these novel regulators in normal development of sexual dimorphisms, including the differentiation of ovaries and testes, the genital tract including prostate, epididymis and uterus, as well as mammary glands. In addition, particular attention is paid on their role in pathophysiological processes within the reproductive tract. The power of next generation sequencing has proved to be an invaluable tool to discover new non-coding RNAs. While the identification of non-coding RNA is relatively easy, analysing their function represents still a challenge today. In this book, authors present historical and conceptual background information, highlight the ways in which non-coding RNAs function is analysed and present their vision of the future research in their key research area.

Non Coding RNAs

Non Coding RNAs Book
Author : Lütfi Tutar,Sumer Aras,Esen Tutar
Publisher : BoD – Books on Demand
Release : 2020-03-04
ISBN : 1789856558
Language : En, Es, Fr & De

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Book Description :

Noncoding RNAs (ncRNAs) are an attractive research field in the RNA world. ncRNAs play important roles in regulating gene expression in animals, plants, and various human diseases. It is clear that current and further research on ncRNAs will change our knowledge of the nature of genome composition by editing previous dogmas. This book provides an overview of current knowledge on ncRNA research by dealing with miRNA and ncRNA-related human diseases, plant miRNA markers, and the roles of lncRNAs in cancer and epigenetics.

Non Coding RNAs and Human Diseases

Non Coding RNAs and Human Diseases Book
Author : Yujing Li,Ge Shan,Zhao-Qian Teng,Thomas S. Wingo
Publisher : Frontiers Media SA
Release : 2020-07-08
ISBN : 2889638324
Language : En, Es, Fr & De

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Book Description :

Download Non Coding RNAs and Human Diseases book written by Yujing Li,Ge Shan,Zhao-Qian Teng,Thomas S. Wingo, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Non Coding RNAs

Non Coding RNAs Book
Author : Jan Barciszewski
Publisher : Springer Science & Business Media
Release : 2003-08-31
ISBN : 9780306478352
Language : En, Es, Fr & De

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Book Description :

General inspection of a role performed in the cell by RNAs allows us to distinguish three major groups of transcripts: I. protein-coding mRNAs, II. non-coding housekeeping and III. regulatory RNAs. The housekeeping RNAs include RNA classes that are generally, constitutively expressed and whose presence is required for normal function and viability of the cells. On the other hand, a group of regulatory RNAs includes RNA species that are expressed at certain stages of organism development or cell differentiation or as a response to external stimuli and can affect expression of other genes on the levels of transcription or translation. Non-coding RNA transcripts form a heterogeneous class of RNAs that can not be characterized by a single specific function. Initially, the term non-coding RNA (ncRNA) was used primarily to describe polyadenylated and a capped eukaryotic RNAs transcribed by RNA polymerase II, but lacking long open reading frames. Now, this definition can be extended to cover all RNA transcripts that do not show protein-coding capacity and is sometimes used to describe any RNA that does not encode protein, including introns. This book is an in-depth look at the function of Non-Coding RNAs and their relationship to Molecular Biology and Molecular Biology.

Long Noncoding RNAs

Long Noncoding RNAs Book
Author : Vinod Scaria
Publisher : Academic Press
Release : 2017-11
ISBN : 9780128042328
Language : En, Es, Fr & De

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Book Description :

Long Noncoding RNAs: Basic Science to Disease Biology provides an overview of the state-of-the-art methods in the field that have created an understanding of the sequence, structure, function and disease associations of lncRNAs. The decade following the availability of the reference human genome has seen tremendous advancements in the scale and throughput of nucleotide sequencing and its widespread application. This sequencing technology has allowed for rapid, advanced study of the functionalities of lncRNAs and has revealed their intricate and important roles in a variety of biological processes and pathophysiology of diseases. Features approaches to characterize the function of lncRNA Presents information on high-throughput functional screening and imaging Includes a chapter on RNA-Capture Seq for the annotation of lncRNAs

Long Non Coding RNAs in Cancer

Long Non Coding RNAs in Cancer Book
Author : Alfons Navarro
Publisher : Humana
Release : 2021-06-17
ISBN : 9781071615805
Language : En, Es, Fr & De

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Book Description :

This volume presents techniques needed for the study of long non-coding RNAs (lncRNAs) in cancer from their identification to functional characterization. Chapters guide readers through identification of lncRNA expression signatures in cancer tissue or liquid biopsies by RNAseq, single Cell RNAseq, Phospho RNAseq or Nanopore Sequencing techniques; validation of lncRNA signatures by Real time PCR, digital PCR or in situ hybridization; and functional analysis by siRNA or CRISPR based methods for lncRNA silencing or overexpression. Lipid based nanoparticles for delivery of siRNAs in vivo, lncRNA-protein interactions, viral lncRNAs and circRNAs are also treated in this volume. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and practical, Long Non-Coding RNAs in Cancer aims to provide a collection of laboratory protocols, bioinformatic pipelines, and review chapters to further research in this vital field.

Plant Long Non Coding RNAs

Plant Long Non Coding RNAs Book
Author : Julia A. Chekanova,Hsiao-Lin V. Wang
Publisher : Humana Press
Release : 2019-04-20
ISBN : 9781493990443
Language : En, Es, Fr & De

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Book Description :

This volume focuses on various approaches to studying long non-coding RNAs (lncRNAs), including techniques for finding lncRNAs, localization, and observing their functions. The chapters in this book cover how to catalog lncRNAs in various plant species; determining subcellular localization; protein interactions; structures; and RNA modifications. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and innovative, Plant Long Non-Coding RNAs: Methods and Protocols is a valuable resource that aids researchers in understanding the functions of lncRNAs in different plant species, and helps them explore currently uncharted facets of plant biology.

Regulation of Angiogenesis by Long Non coding RNA Rhabdomyosarcoma 2 associated Transcript

Regulation of Angiogenesis by Long Non coding RNA Rhabdomyosarcoma 2 associated Transcript Book
Author : Maha Alaqeeli
Publisher : Unknown
Release : 2019
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

"Non-coding RNAs (ncRNAs) have received considerable attention over the past several years. It has been estimated that 68% of ncRNAs in mammalian cells are long non-coding RNAs (lncRNAs), which are transcripts that are longer than 200 nucleotides. Despite the recent discovery of novel lncRNAs, their functional importance in the regulation of endothelial cell (EC) function including survival, proliferation, migration, and differentiation remains unclear. The first report showing that lncRNAs are expressed in human ECs was published in 2014. It was reported that ~56% of the total RNA transcripts in human umbilical vein endothelial cells (HUVECs) are ncRNAs, with the majority being lncRNAs. Malat1 was the first lncRNA to be linked to the regulation of angiogenesis and several studies have reported that inhibition of its expression causes significant impairment of angiogenesis.To indentify novel lncRNAs that may regulate angiogenesis, we screened using qPCR arrays the expression of eighty six lncRNAs in HUVECs exposed to angiopoietin-1 (Ang1), an important angiogenesis factor that promotes angiogenesis and inhibits inflammation by activating Tie-2 receptors. Our results revealed that exposure to Ang1 for 12 hours alters the expression of several lncRNAs including CCAT2, RMST, FGF14-AS2, SOX2-OT, and HOTAIR. The functional importance of these lncRNAs in the regulation of angiogenesis is unknown. To confirm that the expression of these six lncRNAs is regulated by angiogenic stimuli, we measured their expression in HUVECs exposed to acute hypoxia and those co-cultured with human lung fibroblasts for seven days (EC differentiation assays). We found that both hypoxia and differentiation into tube-like structures result in significant upregulation of the expression of CCAT2, RMST, FGF14-AS, SOX2-OT and HOTAIR. In subsequent experiments, we focused our5attention on assessing the regulation and functional importance of RMST (Rhabdomyosarcoma 2-associated transcript) in the regulation of angiogenesis processes including EC viability, proliferation, migration and differentiation. We first detected the presence of ten isoforms of RMST in various ECs and non-ECs and evaluated their expression in response to hypoxia. Our results indicate that ten isoforms of RMST lncRNA are expressed in various human endothelial and non-endothelial cells and that acute hypoxia and EC differentiation trigger significant upregulation of RMST isoforms expression. We used a loss-of-function approach (knockdown of RMST expression with selective GapmeRs) to evaluate the functional importance of RMST in regulating in vitro angiogenesis processes. Measurements of EC viability, proliferation, migration and differentiation using crystal violet, BrdU incorporation, scratch wound healing and MatrigelÒ differentiation assays, respectively, revealed that RMST knockdown has a negative effect on EC survival and migration, a pro-capillary formation effect on EC differentiation but exerted no significant effect on EC proliferation. We conclude that RMST is a novel potential regulator of angiogenesis"--

Long Non coding RNA Regulation of Immune Homeostasis

Long Non coding RNA Regulation of Immune Homeostasis Book
Author : Jonathan J. Kotzin
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The immune system is comprised of diverse cell types that work together to protect the host from infection and maintain tissue homeostasis. To achieve this complex balance, extracellular cues determine highly specific epigenetic landscapes and transcriptional profiles of each immune cell subtype. New evidence indicates that long non-coding RNAs (lncRNAs) play critical roles in epigenetic and transcriptional regulation in mammals. Here we identify the lncRNA Morrbid, and examine its role in immune function. In Chapter 2, we assess the function of Morrbid at homeostasis and describe its role in finely tuning the lifespan of short-lived myeloid cells. In Chapter 3, we examine Morrbid under inflammatory conditions and illustrate its role in restraining CD8 T cell responses following viral infection. These data demonstrate that lncRNAs can function as highly cell-type specific effectors of extracellular cues to control immunological processes that require rapid and strict regulation.

Molecular Function and Regulation of Non coding RNAs in Multifactorial Diseases

Molecular Function and Regulation of Non coding RNAs in Multifactorial Diseases Book
Author : Mohammadreza Hajjari,Seyed Javad Mowla, Mohammad Ali Faghihi
Publisher : Frontiers Media SA
Release : 2016-12-14
ISBN : 2889450023
Language : En, Es, Fr & De

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Book Description :

Our understanding of the mechanisms underlying the development of multifactorial diseases such as diabetes, autism, Alzheimer's disease, and cancer has been greatly advanced. Non-coding RNAs (ncRNAs), generally including microRNAs and long non-coding RNAs, have recently been found to have potential roles in these diseases, and provide new opportunities for developing both specific biomarkers and therapeutic targets. However, the molecular function and regulation of these RNAs still remains challenging. Numerous studies are focusing on this field in order to fully appreciate the role and regulation of these molecules in human medicine and biology. This e-book aims to bring together new findings on Non-coding RNAs in different complex diseases. It will highlight the characterization, roles, mechanism, and mode of action of these RNAs in complex disorders. We believe that the publications on this topic would be exponentially extended in future. The improved approaches at multiple levels may pave the way for designing and applying new biomarker and therapeutic targets for specific diseases based on these attractive molecules.