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Functional Analysis of Long Non Coding RNAs

Functional Analysis of Long Non Coding RNAs Book
Author : Haiming Cao
Publisher : Humana
Release : 2021-02-12
ISBN : 9781071611579
Language : En, Es, Fr & De

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Book Description :

This detailed volume presents a comprehensive bioinformatic and experimental toolbox for prioritizing, annotating, and functionally analyzing long non-coding RNAs (lncRNAs). Playing a vital role in diverse biological progresses and human disease, lncRNAs have proven to be a challenging subject of study due to our limited understanding of their sequence-function relationships, lack of complete genetic annotation, and the unavailability of systems required to define their functional importance and molecular mechanisms, all of which this book seeks to address. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Functional Analysis of Long Non-Coding RNAs: Methods and Protocols provides a timely and convenient resource to facilitate the identification and characterization of disease-associated human lncRNAs, which aims to shed light on their role in biology and pathophysiology and ultimately lead toward novel therapeutic approaches targeting lncRNAs for the amelioration of human diseases.

Long Non Coding RNAs in Cancer

Long Non Coding RNAs in Cancer Book
Author : Alfons Navarro
Publisher : Humana
Release : 2021-06-24
ISBN : 9781071615805
Language : En, Es, Fr & De

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Book Description :

This volume presents techniques needed for the study of long non-coding RNAs (lncRNAs) in cancer from their identification to functional characterization. Chapters guide readers through identification of lncRNA expression signatures in cancer tissue or liquid biopsies by RNAseq, single Cell RNAseq, Phospho RNAseq or Nanopore Sequencing techniques; validation of lncRNA signatures by Real time PCR, digital PCR or in situ hybridization; and functional analysis by siRNA or CRISPR based methods for lncRNA silencing or overexpression. Lipid based nanoparticles for delivery of siRNAs in vivo, lncRNA-protein interactions, viral lncRNAs and circRNAs are also treated in this volume. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and practical, Long Non-Coding RNAs in Cancer aims to provide a collection of laboratory protocols, bioinformatic pipelines, and review chapters to further research in this vital field.

Long Non Coding RNA

Long Non Coding RNA Book
Author : Syed Mudasir Ahmad,Nazir Ahmad Ganai
Publisher : Cambridge Scholars Publishing
Release : 2020-09-03
ISBN : 1527559106
Language : En, Es, Fr & De

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Book Description :

Long non-coding RNAs (LncRNAs) were originally regarded as “noise” in the genome due to their lack of protein-encoding capacity. However, their roles are now understood to cover various biological functions like gene regulation, cell proliferation, survival, differentiation, and chromatin remodeling. As an emerging group of non-coding RNA molecules, LncRNAs are involved in diverse diseases like cancer, cardiovascular, autoimmune, hormonal disorders, neurodegeneration, and infection, among others. However, knowledge of the mechanisms by which they act is still ambiguous. As such, this book meets the essential need for a textbook dedicated to this topic and provides a comprehensive and captivating account of lncRNA research.

Molecular Biology of Long Non coding RNAs

Molecular Biology of Long Non coding RNAs Book
Author : Ahmad M. Khalil,Jeff Coller
Publisher : Springer Science & Business Media
Release : 2013-09-20
ISBN : 1461486211
Language : En, Es, Fr & De

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Book Description :

​Long non-coding RNAs (lnc)RNAs have emerged as a new paradigm in epigenetic regulation of the genome. Thousands of lncRNAs have been identified and observed in a wide range of organisms. Unlike mRNA, lncRNA have no protein-coding capacity. ​So, while their function is not entirely clear, they may serve as key organizers of protein complexes that allow for higher order regulatory events. Discovering these functions has been the result of intense research done of the last few years, and lncRNA research has had several critical developments during that time. This book will consolidate these ideas and models to better examine the most important issues in lncRNA biology. This will include critical studies that have led to the discovery and annotation of lncRNAs in numerous species, and the molecular mechanisms for a few lncRNA that have begun to emerge.

Long Non coding RNA

Long Non coding RNA Book
Author : Antonin Morillon
Publisher : Elsevier
Release : 2018-02-01
ISBN : 0081023553
Language : En, Es, Fr & De

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Book Description :

The dark side of the genome represents vast domains of the genome that are not encoding for proteins – the basic bricks of cellular structure and metabolism. Up to 98% of the human genome is non-coding and produces so-called long non-coding RNA. Some of these non-coding RNA play fundamental roles in cellular identity, cell development and cancer progression. They are now widely studied in many organisms to understand their function. This book reviews this expanding field of research and present the broad functional diversities of those molecules and their putative fundamental and therapeutic roles and develops the recent history of non-coding RNA, their very much debated classification and how they raise a formidable interest for developmental and tumorigenesis biology. Using classical examples and an extensive bibliography, the book illustrates the most studied and attractive examples of these long non-coding RNA, how they interface with epigenetics, genome integrity and expression and what are the current models of their regulatory mechanisms. This book offers a large review about the long non-coding RNA It presents the broad functional diversities of those molecules It presents pioneer works from the field Provides a comprehensive review of the field Presents fundamental and therapeutic interests

Long Non Coding RNAs

Long Non Coding RNAs Book
Author : Durdica Ugarkovic
Publisher : Springer Science & Business Media
Release : 2011-02-01
ISBN : 9783642165023
Language : En, Es, Fr & De

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Book Description :

Long non-coding RNAs (lncRNAs), tentatively defined as ncRNAs of more than two hundred nucleotides in length, are characterized by the complexity and diversity of their sequences and mechanisms of action. Based on genome-wide studies, more than 3,300 of them exist, but to date only the limited number of functional lncRNAs have been identified and characterized. Nonetheless, lncRNAs have emerged as key molecules involved in the control of transcriptional and posttranscriptional gene regulatory pathways. They take part in the recruitment of chromatin modifying complexes and regulate splicing, localization, stability and translation of the target mRNAs. This book provides an overview of the rapidly advancing field of long ncRNAs, describing the epigenetic and non-epigenetic mechanisms by which they regulate various biological functions in model systems, from yeast to mammals. The role of ncRNAs in sex chromosome dosage compensation in flies and mammals is described, as well as their role in centromere and telomere biology. Long non-coding RNAs involved in environmental stress response and development are presented and their mechanisms of action discussed.

Long Non Coding RNA Biology

Long Non Coding RNA Biology Book
Author : M.R.S. Rao
Publisher : Springer
Release : 2017-08-16
ISBN : 9811052034
Language : En, Es, Fr & De

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Book Description :

This contributed volume offers a comprehensive and detailed overview of the various aspects of long non-coding RNAs and discusses their emerging significance. Written by leading experts in the field, it motivates young researchers around the globe, and offers graduate and postgraduate students fascinating insights into genes and their regulation in eukaryotes and higher organisms.

The Chemical Biology of Long Noncoding RNAs

The Chemical Biology of Long Noncoding RNAs Book
Author : Stefan Jurga,Jan Barciszewski
Publisher : Springer Nature
Release : 2020-10-01
ISBN : 303044743X
Language : En, Es, Fr & De

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Book Description :

This book offers a comprehensive and detailed overview of various aspects of long non-coding RNAs. It discusses their emerging significance in molecular medicine, ranging from human cancers to cardiovascular and metabolic diseases. Transcriptomic studies have demonstrated that the majority of genomes found in complex organisms are expressed in highly dynamic and cell-specific patterns, producing huge numbers of intergenic, antisense and intronic long non-protein-coding RNAs (lncRNAs). Thousands of lncRNAs have been identified, and unlike mRNA, they have no protein-coding capacity. A large repertoire of ncRNAs, actively transcribed from the mammalian genome, control diverse cellular processes, both in terms of development and diseases, through a variety of gene regulatory mechanisms. IncRNAs have emerged as a new paradigm in epigenetic regulation of the genome. Given its scope, the book will be of particular interest to molecular, chemical, cell and developmental biologists, as well as specialists in translational medicine involved in disease-oriented research. It also offers a valuable resource for in silico experts seeking a deeper understanding of lncRNA expression and function through computational analysis of the NGS data.

Long Non Coding RNAs

Long Non Coding RNAs Book
Author : Lin Zhang,Xiaowen Hu
Publisher : Humana
Release : 2021-07-27
ISBN : 9781071616963
Language : En, Es, Fr & De

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Book Description :

This second edition provides a broad spectrum of methods used in long non-coding RNAs (lncRNA) research, ranging from computational annotation of lncRNA genes to molecular and cellular analyses of the function of individual lncRNA. Chapters guide readers through studies used to circular RNAs, RNA splicing, and findings on lncRNA in human diseases. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Long Non-Coding RNAs: Methods and Protocols,Second Edition aims to ensure successful results in the further study of this vital field.

Long Non coding RNAs in Plants

Long Non coding RNAs in Plants Book
Author : Santosh Kumar Upadhyay
Publisher : Academic Press
Release : 2020-11-20
ISBN : 0128214635
Language : En, Es, Fr & De

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Book Description :

Long Non-coding RNAs in Plants: Roles in Development and Stress provides the most recent advances in LncRNAs, including identification, characterization, and potential applications and uses. Introductory chapters include the discovery and development of lncRNAs, a comparative analysis of coding versus non-coding lncRNAs, and the role of lncRNAs in abiotic and biotic stress management. The book then provides methodology and protocols for identification and characterization, followed by chapters covering the various different applications of lncRNAs. Written by leading experts, this book is a must-have resource for students and researchers interested in plant science and biotechnology, horticulture, agriculture, and crop science. Stresses such as heat, cold, drought, heavy metals, UV radiations, bacterial and fungal pathogens, and insect pests largely affect the productivity of various horticultural plants and agricultural crops. However, the ever-increasing human population regularly demands an increase in yield and quality of produce. Long non-coding RNAs are associated with various developmental pathways, regulatory systems, abiotic and biotic stress responses, and signaling, and can provide an alternative strategy for stress management in plants. Includes the latest advances and research in long non-coding RNAs in plants Provides alternative strategies for abiotic and biotic stress management in horticultural plants and agricultural crops Focuses on the application and uses of long non-coding RNAs

Long Non Coding RNAs and Immunity

Long Non Coding RNAs and Immunity Book
Author : Adam Williams,Jorge Henao-Mejia
Publisher : Frontiers Media SA
Release : 2021-06-29
ISBN : 2889669173
Language : En, Es, Fr & De

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Book Description :

We acknowledge the initiation and support of this Research Topic by the International Union of Immunological Societies (IUIS). We hereby state publicly that the IUIS has had no editorial input in articles included in this Research Topic, thus ensuring that all aspects of this Research Topic are evaluated objectively, unbiased by any specific policy or opinion of the IUIS.

Non coding RNAs in Complex Diseases

Non coding RNAs in Complex Diseases Book
Author : Xia Li,Juan Xu,Yun Xiao,Shangwei Ning,Yunpeng Zhang
Publisher : Springer
Release : 2018-09-06
ISBN : 9811307199
Language : En, Es, Fr & De

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Book Description :

This book offers an in-depth and comprehensive review on current understanding of regulatory ncRNAs in complex diseases from a view of bioinformatics. It conveys state-of-the-art bioinformatics tools and methods for ncRNAs from computational detection, functional prediction, to their roles in diseases. Computational methods used to investigate uncharacterised ncRNAs in diseases are mainly summarized in seven aspects: DNA variation of ncRNAs in diseases, prioritization of disease-related ncRNAs, dysregulation epigenetic factors that regulate ncRNA misexpression (DNA methylation and histone-modification), complex crosstalk across ncRNAs, ncRNAs acted as competing regulators to mediate the expression of protein-coding genes, non-coding RNAs mediated risk pathways,and their contributions to drug target predictions. The generally used data resources of ncRNAs are also listed in the end. This book provides important information on the current progress in the fast-moving fields of bioinformatics for regulatory ncRNAs. It provides a timely and useful reference for computational biologists, specifically with RNA interests, and other related areas. Prof. Xia Li is a Professor and the Dean of College of Bioinformatics Science and Technology, Harbin Medical University, China. Dr. Yun Xiao, Dr. Juan Xu, Dr. Shangwei Ning and Dr. Yunpeng Zhang are from College of Bioinformatics Science and Technology, Harbin Medical University, China.

Non coding RNA and the Reproductive System

Non coding RNA and the Reproductive System Book
Author : Dagmar Wilhelm,Pascal Bernard
Publisher : Springer
Release : 2015-12-11
ISBN : 940177417X
Language : En, Es, Fr & De

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Book Description :

This book provides an overview of the role and function of regulatory RNAs that lack protein-coding potential in key reproductive tissues. This includes the role of small interfering RNAs (siRNAs), microRNAs (miRNAs), PIWI-interacting RNAs (piRNAs), small nucleolar RNAs (snoRNAs) and long non-coding RNAs (lncRNAs). Through clear, detailed and comprehensive debate, international leading experts discuss the role these novel regulators in normal development of sexual dimorphisms, including the differentiation of ovaries and testes, the genital tract including prostate, epididymis and uterus, as well as mammary glands. In addition, particular attention is paid on their role in pathophysiological processes within the reproductive tract. The power of next generation sequencing has proved to be an invaluable tool to discover new non-coding RNAs. While the identification of non-coding RNA is relatively easy, analysing their function represents still a challenge today. In this book, authors present historical and conceptual background information, highlight the ways in which non-coding RNAs function is analysed and present their vision of the future research in their key research area.

DNA METHYLATION OF MICRO LO

DNA METHYLATION OF MICRO    LO Book
Author : Luqian Wang,王露茜
Publisher : Open Dissertation Press
Release : 2017-01-26
ISBN : 9781361023754
Language : En, Es, Fr & De

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Book Description :

This dissertation, "DNA Methylation of Micro- & Long Non-coding RNA in Chronic Lymphocytic Leukemia" by Luqian, Wang, 王露茜, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: B-cell chronic lymphocytic leukemia (CLL) is characterized accumulation in bone marrow, peripheral blood and secondary lymphoid tissues of neoplastic, mature small B lymphocytes. It is the most common adult leukemia in the western countries but much rarer in Asian countries with an incidence of 3.9/100,000/year in the United States and about 0.45/100,000/year in Hong Kong. Despite being an indolent illness in the majority, it remains an incurable disease with some patients pursuing an aggressive clinical course. Therefore, to optimize treatment outcome, identification of new prognostic markers, and hence better risk-stratification is needed. In the human genome, apart from protein-coding genes (PCGs), with the development of high-throughput RNA sequencing, non-coding RNAs (ncRNAs) with little or no protein-coding capacity were discovered. Based on transcript size, ncRNAs are generally grouped into two major classes: small ncRNAs and lncRNAs. miRNAs, being single-stranded non-coding RNAs measuring 19-25 nucleotides (nt), is an important type of small ncRNAs, which serve as post-transcriptional regulators of gene expression via mRNA cleavage or translational repression of their corresponding target PCGs. lncRNAs, mRNA-like transcripts ranging from 200 nt to 100 kilobases, have been shown to regulate the expression of their target genes through epigenetic, transcriptional or post-transcriptional mechanisms. Indeed, dysregulation of miRNAs and lncRNAs have been implicated in human cancers, suggesting a potential oncogenic or tumor suppressive role for ncRNAs. Apart from histone modification, DNA methylation is another important epigenetic modification leading to gene silencing without altering DNA sequence, and hence impacting cellular signaling and biological processes. In this thesis, the hypothesis that aberrant promoter methylation of tumor suppressor miRNAs or lncRNAs might contribute to CLL leukemogenesis is tested. By the candidate gene approach, the role of DNA methylation of tumor suppressor miRNAs, such as miR-34 family, miR-9 family and miR-3151, together with the lncRNA BM742401 was investigated in CLL. The tumor suppressor role of miR-34b/c, miR-9-3, miR-3151 and BM742401 were demonstrated in CLL cell lines. Remarkably, restoration of miR-9 in CLL cells led to downregulation of NFκB1, which is a known target of miR-9, thereby testifying a role of miR-9-3 methylation in the constitutive activation of NFκB signaling pathway in CLL. Moreover, miR-3151 methylation protected CLL cells from apoptosis through over-expression of both of its direct PCG targets MADD and PIK3R2, leading to constitutive activation of MEK/ERK and PI3K/AKT signaling respectively, and consequently upregulation of MCL1. Furthermore, despite infrequent inactivating TP53 mutation in CLL at diagnosis, methylation of miR-34b/c, which are direct transcriptional targets of TP53, is implicated in the perturbation of the TP53-regulated tumor suppressor network. Finally, in primary CLL samples at diagnosis, frequent methylation of miR-3151 and BM742401 and modest methylation of miR-34b/c and miR-9-3 were demonstrated. Of note, miR-9-3 methylation was shown associated with advanced Rai stage (>= stage 2) in CLL patients, suggesting miR-9-3 methylation as a potential poor risk factor for survival. In conclusion, hypermethylation of tumor suppressor ncRNAs including miR-34b/c, miR-9-3, miR-3151 and

Regulation of Angiogenesis by Long Non coding RNA Rhabdomyosarcoma 2 associated Transcript

Regulation of Angiogenesis by Long Non coding RNA Rhabdomyosarcoma 2 associated Transcript Book
Author : Maha Alaqeeli
Publisher : Unknown
Release : 2019
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

"Non-coding RNAs (ncRNAs) have received considerable attention over the past several years. It has been estimated that 68% of ncRNAs in mammalian cells are long non-coding RNAs (lncRNAs), which are transcripts that are longer than 200 nucleotides. Despite the recent discovery of novel lncRNAs, their functional importance in the regulation of endothelial cell (EC) function including survival, proliferation, migration, and differentiation remains unclear. The first report showing that lncRNAs are expressed in human ECs was published in 2014. It was reported that ~56% of the total RNA transcripts in human umbilical vein endothelial cells (HUVECs) are ncRNAs, with the majority being lncRNAs. Malat1 was the first lncRNA to be linked to the regulation of angiogenesis and several studies have reported that inhibition of its expression causes significant impairment of angiogenesis.To indentify novel lncRNAs that may regulate angiogenesis, we screened using qPCR arrays the expression of eighty six lncRNAs in HUVECs exposed to angiopoietin-1 (Ang1), an important angiogenesis factor that promotes angiogenesis and inhibits inflammation by activating Tie-2 receptors. Our results revealed that exposure to Ang1 for 12 hours alters the expression of several lncRNAs including CCAT2, RMST, FGF14-AS2, SOX2-OT, and HOTAIR. The functional importance of these lncRNAs in the regulation of angiogenesis is unknown. To confirm that the expression of these six lncRNAs is regulated by angiogenic stimuli, we measured their expression in HUVECs exposed to acute hypoxia and those co-cultured with human lung fibroblasts for seven days (EC differentiation assays). We found that both hypoxia and differentiation into tube-like structures result in significant upregulation of the expression of CCAT2, RMST, FGF14-AS, SOX2-OT and HOTAIR. In subsequent experiments, we focused our5attention on assessing the regulation and functional importance of RMST (Rhabdomyosarcoma 2-associated transcript) in the regulation of angiogenesis processes including EC viability, proliferation, migration and differentiation. We first detected the presence of ten isoforms of RMST in various ECs and non-ECs and evaluated their expression in response to hypoxia. Our results indicate that ten isoforms of RMST lncRNA are expressed in various human endothelial and non-endothelial cells and that acute hypoxia and EC differentiation trigger significant upregulation of RMST isoforms expression. We used a loss-of-function approach (knockdown of RMST expression with selective GapmeRs) to evaluate the functional importance of RMST in regulating in vitro angiogenesis processes. Measurements of EC viability, proliferation, migration and differentiation using crystal violet, BrdU incorporation, scratch wound healing and MatrigelÒ differentiation assays, respectively, revealed that RMST knockdown has a negative effect on EC survival and migration, a pro-capillary formation effect on EC differentiation but exerted no significant effect on EC proliferation. We conclude that RMST is a novel potential regulator of angiogenesis"--

Long Non Coding RNA in Non Small Cell Lung Cancers

Long Non Coding RNA in Non Small Cell Lung Cancers Book
Author : Zule Cheng
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Non-small cell lung cancer (NSCLC) accounts for nearly 80% of diagnosed lung cancers. Due to the predominantly late diagnosis of NSCLC and drug resistance in the targeted therapy approaches, the 5-year overall survival rate is still less than 19%. Thus, novel diagnosis and treatment approaches are needed. Many efforts have been made to achieve great progress in understanding the genomic landscape of NSCLC and the molecular mechanisms involved in tumorigenesis. Long non-coding RNAs (lncRNAs) are transcripts longer than 200 nucleotides with little or no protein-coding potential. They are encoded across the genome and are involved in a wide range of cellular and biological processes. Dysregulation of lncRNAs is associated with a number of cancer-related processes, including epigenetic regulation, microRNA silencing, and DNA damage. Furthermore, lncRNAs have been reported to have the potential as biomarker for diagnosis and prognosis, as well as the therapy targets. Here in this chapter, we review some well-characterized lncRNAs associated with NSCLCs and the potential of lncRNAs as biomarkers in the diagnosis and prognosis of NSCLCs.

The Role of Long Non coding RNAs in Pediatric Cancers

The Role of Long Non coding RNAs in Pediatric Cancers Book
Author : Araba Sagoe-Wagner
Publisher : Unknown
Release : 2020
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Emerging studies into long non-coding RNAs in cancers continue to implicate these molecules in roles crucial to tumourigenesis and progression of cancers. Long non-coding RNAs are transcripts greater than 200bp that do not code for protein but have been found to regulate gene expression. Given the extensive knowledge of mutations in the genome that could account for pediatric cancers in children, there is a need for a greater understanding of epigenetic regulation and the epigenome of osteosarcoma and neuroblastoma. LncRNAs contribute to epigenetics, thus these transcripts could also influence the cancers via epigenetic mechanisms. This thesis therefore aims to identify differentially expressed long non-coding RNA in neuroblastoma and osteosarcoma that may have roles which could serve as potential targets in therapeutics. Our findings reveal long non-coding RNAs LINC00261, LINC01133, LINC01268 and LINC01139 that are differentially expressed and could have potential roles in the progression of the disease.

Bioinformatics of Non Coding RNAs with Applications to Biomedicine Recent Advances and Open Challenges

Bioinformatics of Non Coding RNAs with Applications to Biomedicine  Recent Advances and Open Challenges Book
Author : Carlo Maria Croce,Alfredo Ferro,Alessandro Laganà
Publisher : Frontiers Media SA
Release : 2017-01-27
ISBN : 2889450961
Language : En, Es, Fr & De

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Book Description :

The recent discovery of small and long non-coding RNAs (ncRNAs) has represented a major breakthrough in the life sciences. These molecules add a new layer of complexity to biological processes and pathways by revealing a sophisticated and dynamic interconnected system whose structure is just beginning to be uncovered. Genetic and epigenetic aberrations affecting ncRNA gene sequences and their expression have been linked to a variety of pathological conditions, including cancer, cardiovascular and neurological diseases. Latest advances in the development of high throughput analysis techniques may help to shed light on the complex regulatory mechanisms in which ncRNA molecules are involved. Bioinformatics tools constitute a unique and essential resource for non-coding RNA studies, providing a powerful technology to organize, integrate and analyze the huge amount of data produced daily by wet biology experiments in order to discover patterns, identify relationships among heterogeneous biological elements and formulate functional hypotheses. This Research Topic reviews current knowledge, introduces novel methods, and discusses open challenges of this exciting and innovative field in connection with the most important biomedical applications. It consists of four reviews and six original research and methods articles, spanning the full scope of the Research Topic.

Molecular Function and Regulation of Non coding RNAs in Multifactorial Diseases

Molecular Function and Regulation of Non coding RNAs in Multifactorial Diseases Book
Author : Mohammadreza Hajjari,Seyed Javad Mowla, Mohammad Ali Faghihi
Publisher : Frontiers Media SA
Release : 2016-12-14
ISBN : 2889450023
Language : En, Es, Fr & De

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Book Description :

Our understanding of the mechanisms underlying the development of multifactorial diseases such as diabetes, autism, Alzheimer's disease, and cancer has been greatly advanced. Non-coding RNAs (ncRNAs), generally including microRNAs and long non-coding RNAs, have recently been found to have potential roles in these diseases, and provide new opportunities for developing both specific biomarkers and therapeutic targets. However, the molecular function and regulation of these RNAs still remains challenging. Numerous studies are focusing on this field in order to fully appreciate the role and regulation of these molecules in human medicine and biology. This e-book aims to bring together new findings on Non-coding RNAs in different complex diseases. It will highlight the characterization, roles, mechanism, and mode of action of these RNAs in complex disorders. We believe that the publications on this topic would be exponentially extended in future. The improved approaches at multiple levels may pave the way for designing and applying new biomarker and therapeutic targets for specific diseases based on these attractive molecules.

Regulatory Non Coding RNAs

Regulatory Non Coding RNAs Book
Author : Gordon G. Carmichael
Publisher : Humana Press
Release : 2014-09-20
ISBN : 9781493913701
Language : En, Es, Fr & De

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Book Description :

Regulatory Non-Coding RNAs: Methods and Protocols offers a collection of methods for those interested in the discovery, localization, and functional analysis of these non-coding transcripts that have the potential and ability to orchestrate and control gene expression. After a review of the field, this detailed volume continues with methods useful for the study of siRNAs, microRNAs and their targets, techniques concerned with long non-coding RNAs, as well as studies of the critical parameters of functional non-coding RNA protein-RNA interactions and the environment in which they act. Written for the highly successful Methods in Molecular Biology series, chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips for troubleshooting and avoiding known pitfalls. Dependable and easy to use, Regulatory Non-Coding RNAs: Methods and Protocols provides a current, state-of-the-art collection of methods and approaches that will be of value to researchers in this expanding and fascinating field.