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Lipid Signaling And Metabolism

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Lipid Signaling and Metabolism

Lipid Signaling and Metabolism Book
Author : James M. Ntambi
Publisher : Academic Press
Release : 2020-08-09
ISBN : 0128194057
Language : En, Es, Fr & De

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Book Description :

Lipid Signaling and Metabolism provides foundational knowledge and methods to examine lipid metabolism and bioactive lipid signaling mediators that regulate a broad spectrum of biological processes and disease states. Here, world-renowned investigators offer a basic examination of general lipid, metabolism, intracellular lipid storage and utilization that is followed by an in-depth discussion of lipid signaling and metabolism across disease areas, including obesity, diabetes, fatty liver disease, inflammation, cancer, cardiovascular disease and mood-related disorders. Throughout, authors demonstrate how expanding our understanding of lipid mediators in metabolism and signaling enables opportunities for novel therapeutics. Emphasis is placed on bioactive lipid metabolism and research that has been impacted by new technologies and their new potential to transform precision medicine. Provides a clear, up-to-date understanding of lipid signaling and metabolism and the impact of recent technologies critical to advancing new studies Empowers researchers to examine bioactive lipid signaling and metabolism, supporting translation to clinical care and precision medicine Discusses the role of lipid signaling and metabolism in obesity, diabetes, fatty liver disease, inflammation, cancer, cardiovascular disease and mood-related disorders, among others

Membrane Lipid Signaling in Aging and Age Related Disease

Membrane Lipid Signaling in Aging and Age Related Disease Book
Author : M.P. Mattson
Publisher : Elsevier
Release : 2003-05-06
ISBN : 9780080522500
Language : En, Es, Fr & De

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Book Description :

The lipids of cellular membranes not only serve roles in controlling the structure and fluidity of the membrane, but are increasingly recognized for their roles as signalling molecules and modifiers of membrane protein function. Recent studies described in this volume reveal striking changes in membrane lipids during aging and in age-related diseases such as cancer, cardiovascular disease and neurodegenerative disorders. Lipids including inositol phospholipids, cholesterol, sphingolipids and ceramides play important roles in signalling cellular responses to stress and specific stimuli such as growth factors, cytokines and neurotransmitters. One or more of these lipid mediators has been linked to the pathogenesis of age-related diseases. This book provides a comprehensive review of specific membrane lipid mediators and their roles in aging and age-related disease.

Lipid Signaling Protocols

Lipid Signaling Protocols Book
Author : Banafshé Larijani,Rudiger Woscholski,Colin A. Rosser
Publisher : Humana Press
Release : 2014-10-30
ISBN : 9781627038829
Language : En, Es, Fr & De

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Book Description :

Lipid Signaling Protocols assembles in a single volume the various tools and methodologies needed by the interested investigator to unravel lipid dependent signaling and cell function. Divided into two convenient sections, the volume begins by summarizing the physical properties of hydrophobic metabolites as well as the physical methodologies used for their analysis, which leads to the second section and its selection of biological methods, focused around the most relevant lipids, their corresponding metabolizing enzymes and the recognition proteins. Following the highly successful Methods in Molecular BiologyTM series format, the chapters provide readily reproducible laboratory protocols, lists of necessary materials and reagents, and the tips on troubleshooting and avoiding known pitfalls. Contributed to by top researchers in the field, Lipid Signaling Protocols is an essential resource for both experienced and novice researchers who desire a better understanding of the application of physical methodologies in the context of lipid signaling and lipid metabolism in cell biology.

Druggable Lipid Signaling Pathways

Druggable Lipid Signaling Pathways Book
Author : Yasuyuki Kihara
Publisher : Springer Nature
Release : 2020
ISBN : 3030506215
Language : En, Es, Fr & De

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Book Description :

This edited work presents a series of reviews focusing on Druggable Lipid Signaling Pathways. It enables researchers in both academic institutions and industry as well as physicians to understand historical aspects of lipid signaling and future directions of drug discovery targeting lipid signaling pathways. This book provides 9 pathways including acyltransferases, prostanoids, leukotrienes, epoxy fatty acids, sphingolipids, lysophospholipids, endocannabinoids, phosphoinositides, and lipid GPCRs. Readers will discover the importance of each lipid signaling pathway that contributes to broad range of diseases including neurological and neuropsychiatric diseases, pain, metabolic syndromes, cardiovascular diseases, cancer, dermatological diseases, fibrosis, inflammation, etc. Also, readers will recognize that many drugs targeting lipid signaling have been clinically used. Drugs currently under development are also discussed in each chapter, which includes some information about clinical trials and strategic drug designs.

Lipid Signaling Protocols

Lipid Signaling Protocols Book
Author : Banafshé Larijani,Rudiger Woscholski,Colin A. Rosser
Publisher : Humana Press
Release : 2008-11-11
ISBN : 9781588297273
Language : En, Es, Fr & De

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Book Description :

Lipid Signaling Protocols assembles in a single volume the various tools and methodologies needed by the interested investigator to unravel lipid dependent signaling and cell function. Divided into two convenient sections, the volume begins by summarizing the physical properties of hydrophobic metabolites as well as the physical methodologies used for their analysis, which leads to the second section and its selection of biological methods, focused around the most relevant lipids, their corresponding metabolizing enzymes and the recognition proteins. Following the highly successful Methods in Molecular BiologyTM series format, the chapters provide readily reproducible laboratory protocols, lists of necessary materials and reagents, and the tips on troubleshooting and avoiding known pitfalls. Contributed to by top researchers in the field, Lipid Signaling Protocols is an essential resource for both experienced and novice researchers who desire a better understanding of the application of physical methodologies in the context of lipid signaling and lipid metabolism in cell biology.

Lipid Signaling Protocols

Lipid Signaling Protocols Book
Author : Banafshé Larijani,Rudiger Woscholski,Colin A. Rosser
Publisher : Humana Press
Release : 2008-11-11
ISBN : 9781588297273
Language : En, Es, Fr & De

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Book Description :

Lipid Signaling Protocols assembles in a single volume the various tools and methodologies needed by the interested investigator to unravel lipid dependent signaling and cell function. Divided into two convenient sections, the volume begins by summarizing the physical properties of hydrophobic metabolites as well as the physical methodologies used for their analysis, which leads to the second section and its selection of biological methods, focused around the most relevant lipids, their corresponding metabolizing enzymes and the recognition proteins. Following the highly successful Methods in Molecular BiologyTM series format, the chapters provide readily reproducible laboratory protocols, lists of necessary materials and reagents, and the tips on troubleshooting and avoiding known pitfalls. Contributed to by top researchers in the field, Lipid Signaling Protocols is an essential resource for both experienced and novice researchers who desire a better understanding of the application of physical methodologies in the context of lipid signaling and lipid metabolism in cell biology.

Lipid Metabolism in Signaling Systems

Lipid Metabolism in Signaling Systems Book
Author : John N. Fain
Publisher : Academic Press
Release : 2013-10-22
ISBN : 1483288323
Language : En, Es, Fr & De

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Book Description :

Many of the phospholipases and even the receptor for inositol 1,4,5-trisphosphate have recently been cloned and sequenced and play an important role in neurotransmission. Methods developed in recent years for the study of the enzymes and intermediates involved in the regulation of neuronal signal transduction involving phospholipid turnover are presented in this volume. Techniques for examining the role of phosphoinositides in signal transduction Techniques related to protein kinase C Analysis of inositol phosphates Techniques to analyze phospholipid turnover in the brain

Druggable Lipid Signaling Pathways

Druggable Lipid Signaling Pathways Book
Author : Yasuyuki Kihara
Publisher : Springer
Release : 2020-10-18
ISBN : 9783030506209
Language : En, Es, Fr & De

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Book Description :

Lipids are responsible not just for constituting cellular membrane but also for storing energy, transducing signaling, and modifying proteins. Bioactive lipids, or lipid mediators, transduce signaling as intracellular messenger like phosphoinoitides, and also regulate cell-cell communication through G protein-coupled receptors (GPCRs) that are potentially valuable drug targets in many diseases. Until now, about 40 GPCRs within ~300 rhodopsin-like (class A) GPCRs, are identified as lipid GPCRs. Advances of lipid research have enabled to develop novel small molecules targeting lipid GPCRs for several diseases. Most notably, fingolimod (FTY720), a sphingosine 1-phosphate (S1P) receptor modulator, became the first FDA-approved medicine as an orally bioavailable drug for treating relapsing forms of multiple sclerosis (MS). In addition to fingolimod, other drugs targeting lipid GPCRs had been developed such as latanoprost (prostaglandin F2a analogue, used for ocular hypertension and glaucoma), epoprostenol and treprostinil (prostaglandin I2 analogue, used for pulmonary arterial hypertension), montelukast and pranlukast (cysteinyl leukotriene receptor antagonist, used for asthma and allergies), etc. Novel drugs are also expected like lysophosphatidic acid (LPA) receptor antagonist for treatment of pulmonary fibrosis. Drug development targeting lipid signalling pathways are backdated to more than a century, when aspirin was synthesized and selling by Bayer, while the basic mechanism of aspirin's effects (block prostanoid synthesis by inhibiting cyclooxygenases) had not been discovered until 1970s. Nowadays, non-steroidal anti-inflammatory drugs (NSAIDs) like aspirin and ibuprophen are commonly used as antipyretic analgesics and available readily over-the-counter oral drugs. Both upstream and downstream enzymes, such as phospholipase A2s and prostaglandin E synthases, respectively, are also potential therapeutic targets for inflammatory diseases. Recent studies of lipid metabolism expand the lipid biology field from pro-inflammatory lipid mediators to anti-inflammatory epoxy fatty acids (epoxyeicosatrienoic acids), and also omega-3 fatty acid-derived pro-resolving lipid mediators (lipoxin, resolvin, and neuroprotectin). These bioactive lipids, their metabolic pathways and receptors are of great interest in developing next-generation anti-inflammatory and pro-resolving drugs for a wide variety of diseases including. This book summarizes not only historical overview of lipid signaling pathways but also provides summary of cutting-edge studies that may provide some hints of novel “druggable” lipid signaling targets.

Lipid 259 Success Secrets 259 Most Asked Questions on Lipid What You Need to Know

Lipid 259 Success Secrets   259 Most Asked Questions on Lipid   What You Need to Know Book
Author : Lillian Nolan
Publisher : Emereo Publishing
Release : 2014-10-07
ISBN : 9781488853210
Language : En, Es, Fr & De

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Book Description :

Lipid: Theory and Practice. There has never been a Lipid Guide like this. It contains 259 answers, much more than you can imagine; comprehensive answers and extensive details and references, with insights that have never before been offered in print. Get the information you need--fast! This all-embracing guide offers a thorough view of key knowledge and detailed insight. This Guide introduces what you want to know about Lipid. A quick look inside of some of the subjects covered: Lipid rafts - Properties of lipid rafts, G-protein - Lipidation, Phospholipids - Phosphosphingolipids, Lipid metabolism, Hepatocyte - Lipid metabolism, Cell membrane - Lipids, Lipid A - Functions, Phospholipids - Analysis, Phospholipid bilayer, Lipid rafts - Visualization of lipid rafts, Lipid rafts - Immunoglobulin E signaling, Lipid membrane, Endotoxin - Lipid A, Sphingolipid metabolism, Biosynthesis - Phospholipids, List of World Health Organization Essential Medicines - Lipid-lowering agents, Lipid - Fatty acids, Membrane lipids, Lipid signaling - Activators of nuclear receptors, AMP-activated protein kinase - Lipid metabolism, Lipid bilayer - Electroporation, Lipidology, Local anesthetic - Treatment of overdose: Lipid rescue, Cell membrane - Phospholipids forming lipid vesicles, Lipid signaling - Retinol derivatives, Lipids - Polyketides, Inborn errors of lipid metabolism, Lipids - Signaling, Membrane fluidity - Charged lipid membranes, Glycerophospholipids - Examples of glycerophospholipids, Phospholipids - Characterization, Lipid droplet - Formation, Lipid rafts - Lipid raft and signal transduction, Lipids - Biosynthesis, Phospholipid transfer protein, Lipid signaling - Glucosylceramide, Stroke - Blood lipids, Food chemistry - Lipids, Scramblase - Lipid metabolism, Dyslipidemia - Classification, and much more...

The Multifaceted Role of Hypoxia Inducible Factor 1 HIF1 in Lipid Metabolism

The Multifaceted Role of Hypoxia Inducible Factor 1  HIF1  in Lipid Metabolism Book
Author : Guomin Shen
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Hypoxia-inducible factor 1 (HIF1) is a master transcription factor and regulates expression of a large number of genes involving many aspects of biology. In addition to HIF1's roles in glucose metabolism and angiogenesis, numerous studies have revealed an emerging role of HIF1 in controlling lipid homeostasis. In this chapter, we discuss that lipid accumulation is related to HIF1's activity in several diseases and the growing evidence demonstrating the functional importance of HIF1 in controlling lipid metabolism. The functions include lipid uptake and trafficking, fatty acid metabolism, sterol metabolism, triacylglycerol synthesis, phospholipid metabolism, lipid droplet biogenesis, and lipid signaling. Defining the role of HIF1 in lipid metabolism is crucial to understand the pathophysiology of lipid in disease and may help us to identify additional target sites for drug development. This review would shed light on our understanding of the critical role of HIF1 in lipid metabolism.

Stearoyl CoA Desaturase Genes in Lipid Metabolism

Stearoyl CoA Desaturase Genes in Lipid Metabolism Book
Author : James M. Ntambi, Ph.D.
Publisher : Springer Science & Business Media
Release : 2013-08-15
ISBN : 146147969X
Language : En, Es, Fr & De

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Book Description :

Obesity and diabetes develop as a complex result of genetic, metabolic and environmental factors and are characterized by increased lipogenesis and lipid accumulation in many tissues. Stearoyl-CoA desaturase (SCD) genes are a critical regulator of lipogenesis and catalyzes the synthesis of monounsaturated fatty acids (MUFA), mainly oleoyl- (18:1n9) and palmitoleoyl-CoA (16:1n7). These MUFAs are the major fatty acid substrates for the synthesis of triglycerides, cholesterol esters, wax esters and membrane phospholipids. There are 4 SCD isoforms (SCD1-4) in mice and two (hSCD1 and hSCD5) expressed in humans. At first glance, stearoyl-CoA desaturase enzyme would be considered a housekeeping enzyme because it synthesizes oleate a well-known fatty acid that is abundant in many dietary sources. However numerous studies have shown that SCD is a very highly regulated enzyme that features in so many physiological processes ranging from fat differentiation, carbohydrate and fat metabolism, inflammation and cancer. The editor’s studies using stearoyl-CoA desaturase knockout (SCD1-/-) mice and studies of other investigators using pharmacological approaches to reduce SCD1 expression in mouse tissues have all established that the expression of SCD1 gene isoform represents a key step in partitioning of lipids between storage and oxidation. High SCD expression favors fat storage leading to obesity while reduced SCD expression favors fat burning and leanness. Although these studies clearly illustrated that SCD1 expression is involved in the development of obesity and insulin resistance, questions remain in the elucidation of the mechanisms involved and role of SCD1. This book includes chapters by leading researchers on SCD Genes in the brain, heart, muscle, liver metabolism, Colitis, and more. ​

Lipid Signaling in Human Diseases

Lipid Signaling in Human Diseases Book
Author : Julian Gomez-Cambronero,Michael A. Frohman
Publisher : Springer Nature
Release : 2020-04-24
ISBN : 3030336689
Language : En, Es, Fr & De

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Book Description :

Lipids are an integral part of cell membrane architecture, are intermediaries in cell metabolism, and are involved in transmitting cell signals from hormones, growth factors and nutrients. A number of lipases and phospholipases, lipid kinases, lipid phosphatases, sphingosine kinases, and their reaction products have been implicated in fundamental cellular processes including cell proliferation, division and migration. These enzymes and their products underlie the molecular mechanisms of numerous human diseases, in particular metabolic disease (diabetes), cancer, neurodegenerative disease and cardiovascular disease. Over the last decade, studies have advanced to the point that a number of inhibitors for these enzymes have been developed to attempt to ameliorate these conditions; some of the inhibitors are currently in human clinical trial. The need for this book is to review the current status of this field and the prospect for the inhibitors to be clinically important.

The Role of Glycosphingolipids in Insulin Signaling and Lipid Metabolism

The Role of Glycosphingolipids in Insulin Signaling and Lipid Metabolism Book
Author : Nora Bijl
Publisher : Unknown
Release : 2009
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download The Role of Glycosphingolipids in Insulin Signaling and Lipid Metabolism book written by Nora Bijl, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Lipid signaling in plants

Lipid signaling in plants Book
Author : Anonim
Publisher : Frontiers E-books
Release : 2021-12-08
ISBN : 2889191486
Language : En, Es, Fr & De

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Book Description :

Download Lipid signaling in plants book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Lipid Mediators and Their Metabolism in the Brain

Lipid Mediators and Their Metabolism in the Brain Book
Author : Akhlaq A. Farooqui
Publisher : Springer Science & Business Media
Release : 2011-08-12
ISBN : 9781441999405
Language : En, Es, Fr & De

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Book Description :

Lipid Mediators and Their Metabolism in the Brain presents readers with cutting edge and comprehensive information not only on the synthesis and degradation of glycerophospholipid-, sphingolipid-, and cholesterol-derived lipid mediators, but also their involvement in neurological disorders. It is hoped that this monograph will be useful not only to postgraduate student and their teachers, but also to research scientists and physicians, who are curious about the generation and roles of lipid mediators in the brain.

Bioactive Lipids in Health and Disease

Bioactive Lipids in Health and Disease Book
Author : Andres Trostchansky,Homero Rubbo
Publisher : Springer
Release : 2019-05-28
ISBN : 3030114880
Language : En, Es, Fr & De

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Book Description :

The purpose of this book is to introduce the readers on the perspective of the role that unsaturated fatty acids and complex lipids play on health and disease. Bioactive lipids can be modified affecting membrane composition, structure and fluidity in addition to changes in cell signaling associated to lipid-protein (membrane receptors) interactions, issues that are addressed by the authors. This book analyzes key topics involving bioactive lipids and their role in normal signaling and the mechanisms of disease. The book navigates from structural studies of oxidized and non-oxidized lipids to the reactions and cell signaling processes that bioactive lipids play in cardiovascular and neurodegenerative diseases. The book contains the recent advances reported in the literature about lipidomics as well as the role that lipid-derived compounds exert on unfolded protein response and lipid metabolism and disease. This book represents a state of the art introduction to lipid metabolism from a biochemical to an in vivo overview being an useful tool for students and investigators. We hope the mechanistic observations on the role of bioactive lipids in health and disease serve a perspective to improve the existing treatments or propose new lipid-based pharmacology

Inositol Phospholipid Metabolism and Phosphatidyl Inositol Kinases

Inositol Phospholipid Metabolism and Phosphatidyl Inositol Kinases Book
Author : A. Kuksis
Publisher : Gulf Professional Publishing
Release : 2003-09-26
ISBN : 9780444513045
Language : En, Es, Fr & De

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Book Description :

The development of advanced methods for isolation, identification and quantification of old and new inositol lipids and inositol phosphtes from natural and synthetic systems has been a major advancing force in phosphoinositol research. The writing of this book was undertaken as an opportunity fo examine the analytical validity of the biochemical transformations that constitute the basis of the lipid signaling pathways.

Lipid Signaling in T Cell Development and Function

Lipid Signaling in T Cell Development and Function Book
Author : Karsten Sauer,Klaus Okkenhaug
Publisher : Frontiers Media SA
Release : 2015-11-12
ISBN : 2889196976
Language : En, Es, Fr & De

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Book Description :

Lipids are best known as energy storing molecules and core-components of cellular membranes, but can also act as mediators of cellular signaling. This is most prominently illustrated by the paramount importance of the phospholipase C (PLC) and phosphoinositide 3-kinase (PI3K) signaling pathways in many cells, including T cells and cancer cells. Both of these enzymes use the lipid phosphatidylinositol(4,5)bisphosphate (PIP2) as their substrate. PLCs produce the lipid product diacylglycerol (DAG) and soluble inositol(1,4,5)trisphosphate (IP3). DAG acts as a membrane tether for protein kinase C and RasGRP proteins. IP3 is released into the cytosol and controls calcium release from internal stores. The PI3K lipid product phosphatidylinositol(3,4,5)trisphosphate (PIP3) controls signaling by binding and recruiting effector proteins such as Akt and Itk to cellular membranes. Recent research has unveiled important signaling roles for many additional phosphoinositides and other lipids. The articles in this volume highlight how multiple different lipids govern T cell development and function through diverse mechanisms and effectors. In T cells, lipids can orchestrate signaling by organizing membrane topology in rafts or microdomains, direct protein function through covalent lipid-modification or non-covalent lipid binding, act as intracellular or extracellular messenger molecules, or govern T cell function at the level of metabolic regulation. The cellular activity of certain lipid messengers is moreover controlled by soluble counterparts, exemplified by symmetric PIP3/inositol(1,3,4,5)tetrakisphosphate (IP4) signaling in developing T cells. Not surprisingly, lipid producing and metabolizing enzymes have gained attention as potential therapeutic targets for immune disorders, leukemias and lymphomas.

Lipid Mediated Signaling

Lipid Mediated Signaling Book
Author : Eric J. Murphy,Eric Murphy,Thad Rosenberger,Thad A. Rosenberger
Publisher : CRC Press
Release : 2010-03-05
ISBN : 9780849381423
Language : En, Es, Fr & De

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Book Description :

As the highly anticipated update to Lipid Second Messengers (CRC Press, 1999), Lipid-Mediating Signaling is a current and comprehensive overview of research methods used in lipid-mediated signal transduction. Pioneering experts provide a much-needed distillation of a decade’s worth of advances in research techniques that are pertinent in understanding how lipid-mediated signal transduction ties to pathologic disorders. Part I describes methods used to identify activities of and assay the expression of different enzymes involved in lipid-mediated signaling. Part II highlights the use of mass spectrometry to ascertain the lipid content in various systems. Part III contains two chapters devoted to techniques used to determine the role of lipids in the activation of gene transcription. Part IV rounds out the book’s solid coverage by focusing on methods used to assess fatty acid uptake and metabolism. Lipid-Mediating Signaling is an unrivaled reference for this rapidly expanding, yet resource-limited field, and it is a valuable resource for for cell biologists, biochemists, and pharmacologists, as well as for researchers studying signaling transduction.