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Linking Neuroinflammation And Glial Phenotypic Changes In Neurological Diseases

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Linking Neuroinflammation and Glial Phenotypic Changes in Neurological Diseases

Linking Neuroinflammation and Glial Phenotypic Changes in Neurological Diseases Book
Author : Yu Tang,Xuping Li,Xiaobo Mao
Publisher : Frontiers Media SA
Release : 2020-01-15
ISBN : 2889634108
Language : En, Es, Fr & De

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Download Linking Neuroinflammation and Glial Phenotypic Changes in Neurological Diseases book written by Yu Tang,Xuping Li,Xiaobo Mao, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Oxidative Stress and Dietary Antioxidants in Neurological Diseases

Oxidative Stress and Dietary Antioxidants in Neurological Diseases Book
Author : Colin R. Martin,Victor R Preedy
Publisher : Academic Press
Release : 2020-06-12
ISBN : 0128177810
Language : En, Es, Fr & De

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Book Description :

Oxidative Stress and Dietary Antioxidants in Neurological Diseases provides an overview of oxidative stress in neurological diseases and associated conditions, including behavioral aspects and the potentially therapeutic usage of natural antioxidants in the diet. The processes within the science of oxidative stress are described in concert with other processes, such as apoptosis, cell signaling, and receptor mediated responses. This approach recognizes that diseases are often multifactorial and oxidative stress is a single component of this. The book examines basic processes of oxidative stress—from molecular biology to whole organs—relative to cellular defense systems, and across a range of neurological diseases. Sections discuss antioxidants in foods, including plants and components of the diet, examining the underlying mechanisms associated with therapeutic potential and clinical applications. Although some of this material is exploratory or preclinical, it can provide the framework for further in-depth analysis or studies via well-designed clinical trials or the analysis of pathways, mechanisms, and components in order to devise new therapeutic strategies. Very often oxidative stress is a feature of neurological disease and associated conditions which either centers on or around molecular and cellular processes. Oxidative stress can also arise due to nutritional imbalance during a spectrum of timeframes before the onset of disease or during its development. Offers an overview of oxidative stress from molecular biology to whole organs Discusses the potentially therapeutic usage of natural antioxidants in the patient diet Provides the framework for further in-depth analysis or studies of potential treatments

Role of Glial Cells of the Central and Peripheral Nervous System in the Pathogenesis of Neurodegenerative Disorders

Role of Glial Cells of the Central and Peripheral Nervous System in the Pathogenesis of Neurodegenerative Disorders Book
Author : Guanghui Wang,Gerald Muench,Yong-Jing Gao,Haigang Ren,Subashchandrabose Chinnathambi
Publisher : Frontiers Media SA
Release : 2022-05-26
ISBN : 288976236X
Language : En, Es, Fr & De

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Book Description :

Download Role of Glial Cells of the Central and Peripheral Nervous System in the Pathogenesis of Neurodegenerative Disorders book written by Guanghui Wang,Gerald Muench,Yong-Jing Gao,Haigang Ren,Subashchandrabose Chinnathambi, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Nutrition and Immunity

Nutrition and Immunity Book
Author : Maryam Mahmoudi,Nima Rezaei
Publisher : Springer
Release : 2019-07-30
ISBN : 3030160734
Language : En, Es, Fr & De

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Book Description :

This volume provides readers with a systematic assessment of current literature on the link between nutrition and immunity. Chapters cover immunonutrition topics such as child development, cancer, aging, allergic asthma, food intolerance, obesity, and chronic critical illness. It also presents a thorough review of microflora of the gut and the essential role it plays in regulating the balance between immune tolerance and inflammation. Written by experts in the field, Nutrition and Immunity helps readers to further understand the importance of healthy dietary patterns in relation to providing immunity against disorders and offering readily available immunonutritional programming in clinical care. It will be a valuable resource for dietitians, immunologists, endocrinologists and other healthcare professionals.

Neuroinflammation and Neurodegeneration

Neuroinflammation and Neurodegeneration Book
Author : Phillip K. Peterson,Michal Toborek
Publisher : Springer
Release : 2014-07-08
ISBN : 149391071X
Language : En, Es, Fr & De

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Book Description :

State of the art reviews by experts in the fields of neuroscience, immunology, microbiology/infectious diseases and pharmacology addressing the convergence of the immune system (neuroinflammation) and the loss of neurons (neurodegeneration). Many of the diseases that are discussed in the book are of epidemic proportion, e.g., Alzheimer’s disease, Parkinson’s disease, stroke, viral encephalitides and substance abuse. In addition to discussions of the involvement of neuroinflammation and neurodegeneration in these disorders, scientific reviews are presented on the cells and mediators that participate in defense of and damage to the nervous system. With rare exception, no or inadequate treatment exists for the diseases discussed in this book. An underlying premise of the book is that understanding of their shared pathogenic mechanisms will lead to improved therapies. Given the rapid evolution of the field of Neuroimmune Pharmacology, readers will find this book to be the most timely and authoritative reference on the subject of each of its chapters.

Mechanisms of Neuroinflammation

Mechanisms of Neuroinflammation Book
Author : Gonzalo Emiliano Aranda Abreu
Publisher : BoD – Books on Demand
Release : 2017-08-23
ISBN : 9535134515
Language : En, Es, Fr & De

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Book Description :

"Mechanisms of Neuroinflammation" book explains how the neuronal cells become swollen at the moment of the blood-brain barrier disruption and how they lose their immunological isolation. A cascade of cytokines and immune cells from the bloodstream enters the nervous system, inflaming neurons and activating the glia. This produces a neuroinflammatory process that can generate different neurodegenerative diseases. Better understanding of mechanisms that are activated at the time when the damage to the brain occurs could lead to the development of suitable therapies that revert the neuronal inflammation and thus prevent further damage to the nervous system.

Common Pathways Linking Neurodegenerative Diseases The Role of Inflammation

Common Pathways Linking Neurodegenerative Diseases     The Role of Inflammation Book
Author : Grzegorz Kreiner,Andrii Domanskyi,Małgorzata Kujawska
Publisher : Frontiers Media SA
Release : 2021-11-01
ISBN : 2889715639
Language : En, Es, Fr & De

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Book Description :

Download Common Pathways Linking Neurodegenerative Diseases The Role of Inflammation book written by Grzegorz Kreiner,Andrii Domanskyi,Małgorzata Kujawska, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The Role of Glia in Alzheimer s Disease

The Role of Glia in Alzheimer s Disease Book
Author : Beatriz G. Perez-Nievas,Alberto Serrano-Pozo
Publisher : Frontiers Media SA
Release : 2019-03-20
ISBN : 2889457648
Language : En, Es, Fr & De

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Book Description :

We believe that the role of glia is the next frontier to be explored in Alzheimer’s disease research. This eBook is an update on both the current knowledge of astrocytes and microglia involvement in Alzheimer’s disease pathophysiology, and some of the techniques available to study them.

Enteric Glia

Enteric Glia Book
Author : Brian D. Gulbransen
Publisher : Biota Publishing
Release : 2014-07-01
ISBN : 1615046615
Language : En, Es, Fr & De

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Book Description :

The enteric nervous system (ENS) is a complex neural network embedded in the gut wall that orchestrates the reflex behaviors of the intestine. The ENS is often referred to as the “little brain” in the gut because the ENS is more similar in size, complexity and autonomy to the central nervous system (CNS) than other components of the autonomic nervous system. Like the brain, the ENS is composed of neurons that are surrounded by glial cells. Enteric glia are a unique type of peripheral glia that are similar to astrocytes of the CNS. Yet enteric glial cells also differ from astrocytes in many important ways. The roles of enteric glial cell populations in the gut are beginning to come to light and recent evidence implicates enteric glia in almost every aspect of gastrointestinal physiology and pathophysiology. However, elucidating the exact mechanisms by which enteric glia influence gastrointestinal physiology and identifying how those roles are altered during gastrointestinal pathophysiology remain areas of intense research. The purpose of this e-book is to provide an introduction to enteric glial cells and to act as a resource for ongoing studies on this fascinating population of glia. Table of Contents: Introduction / A Historical Perspective on Enteric Glia / Enteric Glia: The Astroglia of the Gut / Molecular Composition of Enteric Glia / Development of Enteric Glia / Functional Roles of Enteric Glia / Enteric Glia and Disease Processes in the Gut / Concluding Remarks / References / Author Biography

Modulating Glial Cells Phenotype New Findings and Therapies

Modulating Glial Cells Phenotype  New Findings and Therapies Book
Author : Alberto Javier Ramos,Yolanda Diz-Chaves,Maria Jose Bellini
Publisher : Frontiers Media SA
Release : 2020-12-21
ISBN : 2889661830
Language : En, Es, Fr & De

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Book Description :

Download Modulating Glial Cells Phenotype New Findings and Therapies book written by Alberto Javier Ramos,Yolanda Diz-Chaves,Maria Jose Bellini, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Glial and Neural Stem Cells as New Therapeutic Targets for Neurodegenerative Disorders

Glial and Neural Stem Cells as New Therapeutic Targets for Neurodegenerative Disorders Book
Author : Sara Xapelli,Maria J. Diógenes,Vincenzo Crunelli,Carlos P. Fitzsimons,Sandra H. Vaz
Publisher : Frontiers Media SA
Release : 2020-06-08
ISBN : 2889637417
Language : En, Es, Fr & De

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Book Description :

Download Glial and Neural Stem Cells as New Therapeutic Targets for Neurodegenerative Disorders book written by Sara Xapelli,Maria J. Diógenes,Vincenzo Crunelli,Carlos P. Fitzsimons,Sandra H. Vaz, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Peripheral Immunity in Parkinson s Disease Emerging Role and Novel Target for Therapeutics

Peripheral Immunity in Parkinson s Disease  Emerging Role and Novel Target for Therapeutics Book
Author : Cristoforo Comi,Marco Cosentino,Rodrigo Pacheco
Publisher : Frontiers Media SA
Release : 2019-12-23
ISBN : 2889632857
Language : En, Es, Fr & De

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Book Description :

Download Peripheral Immunity in Parkinson s Disease Emerging Role and Novel Target for Therapeutics book written by Cristoforo Comi,Marco Cosentino,Rodrigo Pacheco, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Microglial Polarization in the Pathogenesis and Therapeutics of Neurodegenerative Diseases

Microglial Polarization in the Pathogenesis and Therapeutics of Neurodegenerative Diseases Book
Author : Yu Tang,Isidre Ferrer
Publisher : Frontiers Media SA
Release : 2022-08-18
ISBN : 2889455254
Language : En, Es, Fr & De

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Book Description :

Microglia-mediated neuroinflammation is one of the shared prominent hallmarks among various forms of neurodegeneration. Depending on the milieu in which microglia become activated, the polarization of microglia shows to be heterogeneous with diverse functional phenotypes that range from pro-inflammatory phenotypes to immunosuppressive phenotypes. Therefore, targeting microglial polarization holds great promise for the treatment of neurodegeneration. This eBook focuses on the potential mechanisms of microglial polarization that are critically associated with a broad spectrum of neurodegenerative diseases, including Parkinson’s disease (PD), Alzheimer’s disease (AD), Amyotrophic lateral sclerosis (ALS), Huntington’s disease (HD), Traumatic brain injury (TBI), glaucomatous neurodegeneration and prion diseases. This topic also involves the therapeutic targeting of microglial polarization by nutritional and pharmacological modulators. Moreover, this topic describes advanced technologies employed for studying microglia. Age-related changes in microglia functions are also discussed. Overall, this eBook provides comprehensive understandings of microglial polarization in the course of neurodegeneration, linking with aging-related microglial alterations and technologies developed for microglial studies. Hopefully, it will also give comprehensive insights into various aspects of therapeutic treatment for neurodegeneration, through targeting microglial polarization.

Quality Control of Cellular Protein in Neurodegenerative Disorders

Quality Control of Cellular Protein in Neurodegenerative Disorders Book
Author : Uddin, Md. Sahab,Ashraf, Ghulam Md.
Publisher : IGI Global
Release : 2020-02-14
ISBN : 1799813185
Language : En, Es, Fr & De

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Book Description :

Protein misfolding and aggregation are hallmarks of several neurodegenerative proteinopathies. Though multiple factors like aging, oxidative stress, mitochondrial dysfunction, proteotoxic insults, genetic inconsistency, etc. are responsible for the dysfunction of the neuronal protein quality control system, targeting protein quality control has become an auspicious approach to halt the propagation of neurodegeneration. Quality Control of Cellular Protein in Neurodegenerative Disorders provides diverse aspects exploring the role of the protein quality control in neurodegenerative disorders and potential therapeutic strategies to combat the development and propagation of neurodegeneration. Featuring coverage on a broad range of topics such as molecular chaperones, protein misfolding, and stress signaling, this book is ideally designed for neurobiologists, neuropsychologists, neurophysiologists, medical professionals, neuropathologists, researchers, academicians, students, and practitioners engaged in studies of the protein quality control system in neuronal cells.

Microglia in Health and Disease

Microglia in Health and Disease Book
Author : Marie-Ève Tremblay,Amanda Sierra
Publisher : Springer
Release : 2014-09-22
ISBN : 1493914294
Language : En, Es, Fr & De

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Book Description :

These past few years have witnessed a revolution in our understanding of microglia, especially since their roles in the healthy central nervous system (CNS) have started to unravel. These cells were shown to actively maintain health, in concert with neurons and other types of CNS cells, providing further insight into their involvement with diseases. Edited by two pioneers in the field, Marie-Ève Tremblay and Amanda Sierra, Microglia in health and disease aims to share with the broader scientific community some of the recent discoveries in microglia research, from a broad perspective, with a collection of 19 chapters from 52 specialists working in 11 countries across 5 continents. To set microglia on the stage, the book begins by explaining briefly who they are, what they do in the healthy and diseased CNS, and how they can be studied. The first section describes in more details their physiological roles in the maturation, function, and plasticity of the CNS, across development, adolescence, adulthood, neuropathic pain, addiction, and aging. The second section focuses on their implication in pathological conditions impairing the quality of life: neurodevelopmental and neuropsychiatric disorders, AIDS, and multiple sclerosis; and in leading causes of death: ischemia and stroke, neurodegenerative diseases, as well as trauma and injury.

Glial Physiology and Pathophysiology

Glial Physiology and Pathophysiology Book
Author : Alexei Verkhratsky,Arthur Butt
Publisher : John Wiley & Sons
Release : 2013-01-31
ISBN : 1118402057
Language : En, Es, Fr & De

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Book Description :

Glial Physiology and Pathophysiology provides a comprehensive, advanced text on the biology and pathology of glial cells. Coverae includes: the morphology and interrelationships between glial cells and neurones in different parts of the nervous systems the cellular physiology of the different kinds of glial cells the mechanisms of intra- and inter-cellular signalling in glial networks the mechanisms of glial-neuronal communications the role of glial cells in synaptic plasticity, neuronal survival and development of nervous system the cellular and molecular mechanisms of metabolic neuronal-glial interactions the role of glia in nervous system pathology, including pathology of glial cells and associated diseases - for example, multiple sclerosis, Alzheimer's, Alexander disease and Parkinson's Neuroglia oversee the birth and development of neurones, the establishment of interneuronal connections (the 'connectome'), the maintenance and removal of these inter-neuronal connections, writing of the nervous system components, adult neurogenesis, the energetics of nervous tissue, metabolism of neurotransmitters, regulation of ion composition of the interstitial space and many, many more homeostatic functions. This book primes the reader towards the notion that nervous tissue is not divided into more important and less important cells. The nervous tissue functions because of the coherent and concerted action of many different cell types, each contributing to an ultimate output. This reaches its zenith in humans, with the creation of thoughts, underlying acquisition of knowledge, its analysis and synthesis, and contemplating the Universe and our place in it. An up-to-date and fully referenced text on the most numerous cells in the human brain Detailed coverage of the morphology and interrelationships between glial cells and neurones in different parts of the nervous system Describes the role og glial cells in neuropathology Focus boxes highlight key points and summarise important facts Companion website with downloadable figures and slides

Glial Cells Managers of Neuro immunity

Glial Cells  Managers of Neuro immunity Book
Author : Carlos Barcia,Gilles J. Guillemin,James F. Curtin,Jeffrey M. Zirger
Publisher : Frontiers Media SA
Release : 2016-05-30
ISBN : 2889198359
Language : En, Es, Fr & De

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Book Description :

Immune responses within the brain are still scarcely explored. Nerve tissue damage is accompanied by the activation of glial cells, primarily microglia and astroglia, and such activation is responsible for the release of cytokines and chemokines that maintain the local inflammatory response and actively recruit lymphocytes and monocytes to the damaged areas. Theoretically, these responses are designed to repair the brain damage. However, alterations, or a chronic perpetuation of these responses may underlie a number of neuro-pathologies. It is thought that each inflammatory scenario within the brain have a specific biochemical footprint characterized by the release of determined cytokines, chemokines and growing factors able to define particular immunological responses. Alongside, glial cells transform their cell body, become larger and develop higher number of branches adopting an active morphological phenotype. These changes are related with the search of interactions with other cells, such as bystander resident cells of the brain parenchyma, but also cells homing from the blood stream. In this process, microglia and astrocytes communicates with other cells by the formation of specific intercellular connections that are still poorly understood. These interactions are complex and entail the arrangement of cytoskeletal compounds, secretory and phagocytic domains. In this particular crosstalk there is a two-way communication in which glial cells and target cells come together establishing interfaces with specific information exchange. This way, glial cells orchestrate the particular response recruiting cellular subsets within the central nervous system and organizing the resolution of the brain damage. In this Frontiers Research Topic, we compile a selection of articles unfolding diverse aspects of glial-derived inflammation, focused on neurodegenerative diseases and other nervous system disorders, with special emphasis on microglia/macrophages as leading actors managing neuro-immunity.

Neuroglia in Neurodegenerative Diseases

Neuroglia in Neurodegenerative Diseases Book
Author : Alexei Verkhratsky,Margaret S. Ho,Robert Zorec,Vladimir Parpura
Publisher : Springer Nature
Release : 2019-10-03
ISBN : 9811399131
Language : En, Es, Fr & De

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Book Description :

This book provides a comprehensive overview of the role of neuroglia in neurodegenerative diseases. Neuroglia are the most abundant cells in the nervous system and consist of several distinct cell types, such as astrocytes, oligodendrocytes,and microglia. Accumulating evidence suggests that neuroglia participate in the neurodegenerative process, and as such are essential players in a variety of diseases, including Alzheimer’s, Parkinson’s, and Huntington’s. Intended for researchers and students, the book presents recent advances concerning the biology of neuroglia as well as their interaction with neurons during disease progression. In addition, to highlight the function of neuroglia in different types of neurodegenerative disease, it also discusses their mechanisms and effects on protecting or damaging neurons.

Transactions of the Royal Society of South Australia Incorporated

Transactions of the Royal Society of South Australia  Incorporated Book
Author : Royal Society of South Australia
Publisher : Unknown
Release : 1983
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Transactions of the Royal Society of South Australia Incorporated book written by Royal Society of South Australia, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Astrocyte

Astrocyte Book
Author : Maria Teresa Gentile,Luca Colucci D’Amato
Publisher : BoD – Books on Demand
Release : 2018-03-21
ISBN : 9535138855
Language : En, Es, Fr & De

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Book Description :

A team of authors from prestigious academic schools contributed to draw up a project that would give a detailed account of astrocyte's morphology and physiology, examining thoroughly all the astrocyte's types; giving an accurate description of their morphology, location, function in the brain; and illustrating their physiology and pathology in terms of dealing with neurons through "gliotransmitters," ionic channels, and membrane receptors expression. This book gives an overview of the crucial role of astrocytes in the physiology of the CNS and in the pathogenesis of several CNS disorders suggesting that the shift from a neurocentric view to one that incorporates astrocytes in disease models for drug discovery is a critical step in renewing drug development strategies to treat neurodegenerative diseases.