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Lead Compounds From Medicinal Plants For The Treatment Of Neurodegenerative Diseases

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Lead Compounds from Medicinal Plants for the Treatment of Neurodegenerative Diseases

Lead Compounds from Medicinal Plants for the Treatment of Neurodegenerative Diseases Book
Author : Christophe Wiart
Publisher : Academic Press
Release : 2013-12-16
ISBN : 0123983835
Language : En, Es, Fr & De

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Book Description :

Lead Compounds from Medicinal Plants for the Treatment of Neurodegenerative Diseases is the second volume in the series, Pharmaceutical Leads from Medicinal Plants. This book includes key pharmacological and chemical evidence to support the selection of promising pre-clinical candidates for the treatment of neurodegenerative diseases. This important addition to the natural product and drug discovery literature contains the history, synonyms, medicinal uses, phytopharmacology, pre-clinical potential, and rationale for each plant selected. By providing critical evaluation of pharmacological data, mechanisms of action, and structural requirements for the development of future neuroprotective agents, this comprehensive reference is a beneficial resource for industry and academic scientists whose research focuses on neurodegenerative drug discovery and development. Incorporates compelling biological activity data and preclinical structure-activity relationships to help you choose promising lead molecules for further research Includes primary source references to the most recent natural product discoveries in the field of neuroprotection in order to promote new drug discovery in this area Contains detailed discussions of important neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease Each plant section includes a critical evaluation of pharmacological, chemical, and toxicological evidence to support the use of the compound in drug discovery research in neurodegeneration

Phytochemicals as Lead Compounds for New Drug Discovery

Phytochemicals as Lead Compounds for New Drug Discovery Book
Author : Chukwuebuka Egbuna,Shashank Kumar,Jonathan C. Ifemeje,Shahira M. Ezzat,Saravanan Kaliyaperumal
Publisher : Elsevier
Release : 2019-09-07
ISBN : 0128178914
Language : En, Es, Fr & De

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Book Description :

Phytochemicals as Lead Compounds for New Drug Discovery presents complete coverage of the recent advances in the discovery of phytochemicals from medicinal plants as models to the development of new drugs and chemical entities. Functional bioactive compounds of plant origin have been an invaluable source for many human therapeutic drugs and have played a major role in the treatment of diseases around the world. These compounds possess enormous structural and chemical diversity and have led to many important discoveries. This book presents fundament concepts and factors affecting the choice for plant-based products, as well as recent advances in computer-aided drug discovery and FDA drug candidacy acceptance criteria. It also details the various bioactive lead compounds and molecular targets for a range of life-threatening diseases including cancer, diabetes, and neurodegenerative diseases. Written by a global team of experts, Phytochemicals as Lead Compounds for New Drug Discovery is an ideal resource for drug developers, phytochemists, plant biochemists, food and medicinal chemists, nutritionists and toxicologists, chemical ecologists, taxonomists, analytical chemists, and other researchers in those fields. It will also be very valuable to professors, students, and researchers in this domain. Presents fundamental concepts and factors affecting choice for plant-based products Details the FDA drug candidacy acceptance criteria, including bottlenecks and way forward Highlights recent advances in computational-based drug discovery Focuses on the discovery of new drugs and potential druggable targets for the treatment of chronic diseases of world importance

Phytomedicine and Alzheimer s Disorder

Phytomedicine and Alzheimer s Disorder Book
Author : Atanu Bhattacharjee,Akula Ramakrishna,M. Obulesu
Publisher : CRC Press
Release : 2020-09-04
ISBN : 9780367332020
Language : En, Es, Fr & De

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Book Description :

Alzheimer's disease, one of the most rapidly growing neurodegenerative disorders, is characterized by progressive loss of memory. Despite several advancements in the field of medicinal therapeutics, a viable treatment for Alzheimer's disease is the need of great importance. Medicinal plants represent a great deal of untapped reservoir of natural medicines and potential source of anti-Alzheimer's drug. The structural diversity of their phytoconstituents makes them a valuable source of novel lead compounds for the quest of drugs to treat Alzheimer's disease. Based on the traditional literature, various new therapeutically active compounds have been isolated from phytoextracts useful in cognitive disorders. The book "Phytomedicine and Alzheimer's disorder"presents information on Mechanistic aspects of neurodegeneration in Alzheimer's disease and role of phytochemicals as restorative agents Helps in understanding the complex biochemical aspects of Alzheimer's disorder Pre-clinical approaches to evaluate drugs targeting Alzheimer's disease Aternative approach to encounter Alzheimer's disease and role of alternative medicine to delay the symptomatic progression of the same Epigenetic alterations in Alzheimer's disease and its therapeutic, dietary interventions This book serves as an excellent resource for scientific investigators, academician, biochemists, botanists, alternative medicine practitioners who are intended to emphasize the role of phytomedicines to treat Alzheimer's disease.

Phytomedicine and Alzheimer s Disease

Phytomedicine and Alzheimer   s Disease Book
Author : Atanu Bhattacharjee,Akula Ramakrishna,M. Obulesu
Publisher : CRC Press
Release : 2020-10-25
ISBN : 1000171361
Language : En, Es, Fr & De

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Book Description :

Alzheimer's disease, one of the most rapidly growing neurodegenerative disorders, is characterized by a progressive loss of memory. Despite several advances in the field of medical therapeutics, a viable treatment for Alzheimer's disease would be of great importance. Medicinal plants represent a largely untapped reservoir of natural medicines and potential sources of anti-Alzheimer’s drugs. The structural diversity of their phytoconstituents makes these plants a valuable source of novel lead compounds in the quest for drugs to treat Alzheimer's disease. Based on traditional literature and up-to-date research, various new therapeutically active compounds have been identified from phytoextracts, which could be useful in the treatment of cognitive disorders. Phytomedicine and Alzheimer’s Disease presents information on Mechanistic aspects of neurodegeneration in Alzheimer’s disease and the role of phytochemicals as restorative agents Understanding the complex biochemical aspects of Alzheimer’s disease Pre-clinical approaches to evaluating drugs to target Alzheimer’s disease Assessing alternative approaches to treating Alzheimer’s disease and the role of alternative medicine to delay the symptomatic progression of this disease Epigenetic changes in Alzheimer’s disease and possible therapeutic or dietary interventions This book serves as an excellent resource for scientific investigators, academics, biochemists, botanists, and alternative medicine practitioners who work to advance the role of phytomedicines in treating Alzheimer’s disease.

Lead Compounds from Medicinal Plants for the Treatment of Cancer

Lead Compounds from Medicinal Plants for the Treatment of Cancer Book
Author : Christophe Wiart
Publisher : Academic Press
Release : 2013
ISBN : 0123983711
Language : En, Es, Fr & De

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Book Description :

Lead Compounds from Medicinal Plants for the Treatment of Cancer is the first volume in the series, Pharmaceutical Leads from Medicinal Plants. The plant species described in this reference have been carefully selected based on pharmacological evidence and represent today's most promising sources of natural products for the discovery of anti-cancer drugs. Containing references to primary source material, over a hundred botanical illustrations, a table of chemical structures and much more, this book is an essential starting point for cancer researchers and those involved in anti-cancer drug discovery helping you identify the best novel lead molecules for further anti-cancer drug development. Provides a compilation of hundreds of medicinal plants from Europe, Asia, North and South America and Africa that contain prominent lead candidates for anti-cancer drug discovery Contains primary source references and hundreds of the most relevant citations from the current literature for additional research Offers cancer researchers and pharmaceutical scientists valuable tools such as chemical structures and promising pharmacological data to help them select the novel lead compounds that will best aid drug discovery.

Plant Extracts in Neurodegenerative Diseases

Plant Extracts in Neurodegenerative Diseases Book
Author : Magisetty Obulesu
Publisher : Academic Press
Release : 2022-08-01
ISBN : 0323957633
Language : En, Es, Fr & De

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Book Description :

Plant Extracts in Neurodegenerative Disease examines the therapeutic efficacy of plant extracts and the lead compounds contained therein that can significantly improve symptoms of diseases of the brain. Providing insights into the protective mechanisms of these bioactive plant compounds to treat Alzheimer’s Disease, Parkinson’s Disease, motor neuron disease, and other neurodegenerative diseases, the book also discusses the pros and cons of using these types of treatments, along with perspectives to overcome current challenges. With chapters looking at individual diseases, readers will learn about studies unique to each condition, including Huntington’s Disease, spinocerebellar ataxia, SMA, ALS and prion disease. Discusses the therapeutic efficacy of plant extracts and their lead bioactive compounds to treat neurodegenerative disease Describes protective mechanisms, pros and cons, and future perspectives Contains individual diseases in each chapter, including Alzheimer’s, Parkinson’s, Huntington’s, motor neuron disease, spinocerebellar ataxia, prion disease, SMA and ALS

Medicinal Plants

Medicinal Plants Book
Author : Mallappa Kumara Swamy,Jayanta Kumar Patra,Gudepalya Renukaiah Rudramurthy
Publisher : CRC Press
Release : 2019-05-10
ISBN : 0429535600
Language : En, Es, Fr & De

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Book Description :

This book details several important medicinal plants, their occurrence, plant compounds and their chemical structures, and pharmacological properties against various human diseases. It also gives information on isolation and structural elucidation of phytocompounds, bio-assays, metabolomic studies, and therapeutical applications of plant compounds.

Bioactive Compounds in Nutraceutical and Functional Food for Good Human Health

Bioactive Compounds in Nutraceutical and Functional Food for Good Human Health Book
Author : Kavita Sharma,Kanchan Mishra,Kula Kamal Senapati,Corina Danciu
Publisher : BoD – Books on Demand
Release : 2021-04-07
ISBN : 1838808876
Language : En, Es, Fr & De

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Book Description :

Bioactive compounds are abundant in nature, particularly in plants, which have the capacity to synthesize phenolics, flavonoids, caffeine, carotenoids, and much more. Different bioactive compounds can change or alter the life process due to their different biological activities. This book examines bioactive compounds and their sources, structures, and potential uses in various industries, including pharmaceuticals, medicine, cosmetics, and food processing.

Studies in Natural Products Chemistry

Studies in Natural Products Chemistry Book
Author : Atta-ur-Rahman
Publisher : Elsevier
Release : 2016-09-30
ISBN : 0444637567
Language : En, Es, Fr & De

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Book Description :

Studies in Natural Products Chemistry: Bioactive Natural Products (Part XIII) is the latest in a series that covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting-edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis, and pharmacology of a diverse array of bioactive natural products. Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to quickly isolate and determine the structures and biological activity of natural products, thus opening up exciting opportunities in the field of new drug development to the pharmaceutical industry. Focuses on the chemistry of bioactive natural products Contains contributions by leading authorities in the field Presents sources of new pharmacophores

Evidence Based Validation of Herbal Medicine

Evidence Based Validation of Herbal Medicine Book
Author : Pulok K. Mukherjee
Publisher : Elsevier
Release : 2022-07-12
ISBN : 0323984568
Language : En, Es, Fr & De

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Book Description :

Globalization in the context of drug development has increased the use of natural products worldwide. The trends in use of herbal medicine in therapeutics is becoming more popular and is still open to fascinating realms of research. ‘Evidence-Based Validation of Herbal Medicines’ brings together current thinking and practice in the areas of characterization and validation of natural products. This book describes different approaches and techniques for evaluating the quality, safety and efficacy of herbal medicine, particularly methods to assess their activity and understand the compounds responsible and their probable underlying mechanisms of action, which improve the level of understanding of various aspects on evaluation of natural products. This book is an effort to bring together the views, expertise and experiences of scientific experts in the field of medicinal plant research. This will be useful for the researcher to know more about the natural lead with their validation and also useful to exploit traditional medicines, leading to discovery and development of newer drugs through translational research with cutting edge technologies on natural remedies. This book will be an essential reading for the researchers whose professional life impinges on the use of natural resources. Includes state-of-the-art methods for detecting, isolating, and performing structure elucidation by degradation and spectroscopic techniques Highlights the trends in validation and value addition of herbal medicine with different scientific approaches used in therapeutics Contains several all-new chapters on topics such as traditional-medicine-inspired drug development to treat emerging viral diseases, medicinal plants in antimicrobial resistance, TLC bio profiling, botanicals as medicinal foods, bioprospecting and bioassay-guided isolation of medicinal plants, immunomodulators from medicinal plants, and more

Ethnopharmacology of Eastern European Countries

Ethnopharmacology of Eastern European Countries Book
Author : Andrei Mocan,Gianina Crișan,Marina Sokovic,Alexander N. Shikov
Publisher : Frontiers Media SA
Release : 2022-01-12
ISBN : 2889740390
Language : En, Es, Fr & De

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Book Description :

Download Ethnopharmacology of Eastern European Countries book written by Andrei Mocan,Gianina Crișan,Marina Sokovic,Alexander N. Shikov, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Medicinal Natural Products A Disease Focused Approach

Medicinal Natural Products  A Disease Focused Approach Book
Author : Anonim
Publisher : Academic Press
Release : 2020-09-21
ISBN : 0128210206
Language : En, Es, Fr & De

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Book Description :

Medicinal Natural Products: A Disease-Focused Approach, Volume 55 in the Annual Reports in Medicinal Chemistry series, highlights the applications of natural products as medicines or prospective medicinal leads for the treatment of various human ailments. Each chapter covers a particular disease area or medical condition, with chapters in this new release covering Medicinal Natural Products – An Introduction, Anticancer Natural Products, Antimicrobial Natural Products, Antimalarial and Antiparasitic Natural Products, Anti-inflammatory Natural Products, Neuroprotective Natural Products, Hepatoprotective Natural Products, Nephroprotective Natural Products, Cancer Chemopreventive Natural Products, Antipsoriatic Natural Products, Medicinal Natural Products in Osteoporosis, Antidiabetic Natural Products, Anti-obesity Natural Products, and much more. Presents a disease-focused perspective Includes the latest on the medicinal chemistry of natural products Covers natural products in drug delivery

Food Aroma Evolution

Food Aroma Evolution Book
Author : Matteo Bordiga,Leo M.L. Nollet
Publisher : CRC Press
Release : 2019-11-15
ISBN : 0429807244
Language : En, Es, Fr & De

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Book Description :

Of the five senses, smell is the most direct and food aromas are the key drivers of our flavor experience. They are crucial for the synergy of food and drinks. Up to 80% of what we call taste is actually aroma. Food Aroma Evolution: During Food Processing, Cooking, and Aging focuses on the description of the aroma evolution in several food matrices. Not only cooking, but also processing (such as fermentation) and aging are responsible for food aroma evolution. A comprehensive evaluation of foods requires that analytical techniques keep pace with the available technology. As a result, a major objective in the chemistry of food aroma is concerned with the application and continual development of analytical methods. This particularly important aspect is discussed in depth in a dedicated section of the book. Features Covers aromatic evolution of food as it is affected by treatment Focuses on food processing, cooking, and aging Describes both classic and new analytical techniques Explains how the flavor perception results are influenced by other food constituents The book comprises a good mix of referenced research with practical applications, also reporting case studies of these various applications of novel technologies. This text represents a comprehensive reference book for students, educators, researchers, food processors, and food industry personnel providing an up-to-date insight. The range of techniques and materials covered provides engineers and scientists working in the food industry with a valuable resource for their work. Also available in the Food Analysis & Properties Series: Ambient Mass Spectroscopy Techniques in Food and the Environment, edited by Leo M.L. Nollet and Basil K. Munjanja (ISBN: 9781138505568) Hyperspectral Imaging Analysis and Applications for Food Quality, edited by N.C. Basantia, Leo M.L. Nollet, and Mohammed Kamruzzaman (ISBN: 9781138630796) Fingerprinting Techniques in Food Authentication and Traceability, edited by Khwaja Salahuddin Siddiqi and Leo M.L. Nollet (ISBN: 9781138197671) For a complete list of books in this series, please visit our website at: www.crcpress.com/Food-Analysis--Properties/book-series/CRCFOODANPRO

Nutraceuticals in Brain Health and Beyond

Nutraceuticals in Brain Health and Beyond Book
Author : Dilip Ghosh
Publisher : Academic Press
Release : 2020-11-12
ISBN : 0128206101
Language : En, Es, Fr & De

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Book Description :

Nutraceuticals in Brain Health and Beyond focuses on a variety of health disorders where intervention with nutritional supplements prove valuable, such as Alzheimer’s, Parkinson’s, autism, and attention-deficit disorder in children. In addition, Nutraceuticals in Brain Health and Beyond addresses "herb-nutra psychiatry" which is a field of research focused on developing a comprehensive, cohesive, and scientifically rigorous evidence base to shift conceptual thinking around the role of diet and nutrition in mental health. Intended for nutrition researchers, nutritionists, dieticians, regulatory bodies, health professionals, and students studying related fields, Nutraceuticals in Brain Health and Beyond will be a useful reference in understanding the links between nutrition and brain health. • Addresses nutritional psychiatry and cognitive health at all stages of the lifespan • Contains extensive coverage of vitamins, minerals, botanicals, and other nutrients • Offers novel insight into cognitive dysfunctions including depression and other neurodegenerative disorders • Explores the role of genomics and epigenetics, including discussion of the gut–brain axis

Naturally Occurring Chemicals against Alzheimer s Disease

Naturally Occurring Chemicals against Alzheimer   s Disease Book
Author : Tarun Belwal,Seyed Mohammad Nabavi,Seyed Fazel Nabavi,Ahmad Reza Dehpour,Samira Shirooie
Publisher : Academic Press
Release : 2020-11-19
ISBN : 0128192135
Language : En, Es, Fr & De

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Book Description :

Naturally Occurring Chemicals against Alzheimer’s Disease offers a detailed discussion on the roles, molecular mechanisms, structural activity relationships, toxicology and clinical data on phytochemicals in relation to Alzheimer’s disease. The book examines the available phytochemicals and plants that are potentially effective, also determining the role and molecular targets of these phytochemicals in combating AD. This comprehensive resource will be helpful to researchers who are working on herbal drugs on AD, phytochemistry, pharmacology, toxicology, clinical trials, neuroscience and advancement in formulations. Provides information on phytochemistry, pharmacology, toxicology, clinical trials, and advancement in formulations specific to Alzheimer’s Disease in a single source Explores natural compounds, which can be more affordable to the majority of Alzheimer’s Disease patients, who will increasingly be in developing countries Covers a wide array of specific chemical compounds

Medicinal Plants for Cardiovascular and Neurodegenerative Aging related Diseases From Bench to Bedside

Medicinal Plants for Cardiovascular and Neurodegenerative Aging related Diseases  From Bench to Bedside Book
Author : Yue Liu,Valentina Echeverria Moran,Youhua Xu
Publisher : Frontiers Media SA
Release : 2020-12-08
ISBN : 2889661601
Language : En, Es, Fr & De

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Book Description :

Download Medicinal Plants for Cardiovascular and Neurodegenerative Aging related Diseases From Bench to Bedside book written by Yue Liu,Valentina Echeverria Moran,Youhua Xu, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Ethnopharmacology Volume I

Ethnopharmacology   Volume I Book
Author : Elaine Elisabetsky,Nina L. Etkin
Publisher : EOLSS Publications
Release : 2009-10-29
ISBN : 1905839960
Language : En, Es, Fr & De

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Book Description :

Ethnopharmacology is a component of Encyclopedia of Biological, Physiological and Health Sciences in the global Encyclopedia of Life Support Systems (EOLSS), which is an integrated compendium of twenty one Encyclopedias. Ethnopharmacology is the scientific study correlating ethnic groups, their health, and how it relates to their physical habits and methodology in creating and using medicines. This Theme on Ethnopharmacology presents the field as an amalgam of perspectives, primarily those of pharmacology, pharmacognosy, anthropology, and botany. It highlights the uniquely biocultural perspective on ethnopharmacology offered by medical anthropology, which underscores that health and healing are culturally constructed and socially negotiated. The definition of ethnopharmacology that frames this volume is: the study of indigenous medical systems that connects the ethnography of health and healing with the physiological relevance of its medical practices. The history of botanical medicines is traced from primate self-medication to contributions to biomedicine. The methods of ethnopharmacologic inquiry are presented from pharmacologic, ecological, ethnographic, data management, and ethical perspectives. Chapters are devoted to plants used in the treatment of specific disorders: cancer, parasitic infection, AIDS, inflammation, diabetes, and cardiovascular and neurodegenerative disorders. The important role that plant medicines play in the developing world is revealed in discussion of ritual and ceremony, safety issues, health care, and biodiversity. These two volumes are aimed at the following a wide spectrum of audiences from the merely curious to those seeking in-depth knowledge: University and College students Educators, Professional practitioners, Research personnel and Policy analysts, managers, and decision makers and NGOs.

MEDICAL AND HEALTH SCIENCES Volume XIII

MEDICAL AND HEALTH SCIENCES   Volume XIII Book
Author : Osmo Otto Paivio Hanninen; Mustafa Atalay; B.P. Mansourian; A. Wojtezak; S.M. Mahfouz; Harry Majewski; Elaine Elisabetsky; Nina L. Etkin; Ralph Kirby; T.G. Downing and M.I. El Gohary
Publisher : EOLSS Publications
Release : 2010-10-12
ISBN : 1848263929
Language : En, Es, Fr & De

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Book Description :

Medical and Health Sciences is a component of Encyclopedia of Biological, Physiological and Health Sciences in the global Encyclopedia of Life Support Systems (EOLSS), which is an integrated compendium of twenty one Encyclopedias. These volume set contains several chapters, each of size 5000-30000 words, with perspectives, applications and extensive illustrations. It carries state-of-the-art knowledge in the fields of Medical and Health Sciences and is aimed, by virtue of the several applications, at the following five major target audiences: University and College Students, Educators, Professional Practitioners, Research Personnel and Policy Analysts, Managers, and Decision Makers and NGOs.

Bioactive Natural products in Drug Discovery

Bioactive Natural products in Drug Discovery Book
Author : Joginder Singh,Vineet Meshram,Mahiti Gupta
Publisher : Springer Nature
Release : 2020-04-30
ISBN : 9811513945
Language : En, Es, Fr & De

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Book Description :

This book highlights different natural products that are derived from the plants and microbes that have shown potential as the lead compounds against infectious diseases and cancer. Natural products represent an untapped source of strikingly diverse chemotypes with novel mechanisms of action and the potential to serve as anticancer and anti-infective agents. The book discusses a range of biotechnologically valuable bioactive compounds and secondary metabolites that have been derived from plant and microorganisms from various ecological niches. It also reviews the latest developments in the field of genomics, bioinformatics and industrial fermentation for harnessing the microbial products for commercial applications. In turn, the book’s closing section reviews important biotechnological applications of various natural products. Combining the expertise of specialists in this field, the book’s goal is to promote the further investigation of natural sources for the development of standardized, safe and effective therapies.

Ethnopharmacology of Medicinal Plants

Ethnopharmacology of Medicinal Plants Book
Author : Christophe Wiart
Publisher : Springer Science & Business Media
Release : 2007-11-04
ISBN : 1597451606
Language : En, Es, Fr & De

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Book Description :

In 1860, Oliver Wendell Holmes pointedly expressed himself to the Massachusetts Medical Society: “I firmly believe that if the whole Material Medica, as now used, could be sunk to the bottom of the sea, it would be all the better for mankind, and all the worst for the fishes.” Should one think the same about the current approach in drug discovery from plants? Probably yes. Despite the spending of billions of US dollars, and three decades of efforts, high-throughput screenings have only allowed the discovery of a couple of drugs. One could have reasonably expected the discovery of an arsenal of drugs from the millions of plant extracts randomly tested, but “hits” can be inactive in vitro or too toxic, some molecules need to be metabolized first to be active, and false-positive and false-negative results are common. The bitter truth is that the robotic approach in discovering drugs from plants has proven, to date, its inability to excavate the hundreds of molecules that will contribute to the health progress of Man. However, one can reasonably see that the last patches of primary rainforest on earth hold still hundreds of spectacularly active drugs that await discovery.