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Late Stage Fluorination Of Bioactive Molecules And Biologically Relevant Substrates

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Late Stage Fluorination of Bioactive Molecules and Biologically Relevant Substrates

Late Stage Fluorination of Bioactive Molecules and Biologically Relevant Substrates Book
Author : Al Postigo
Publisher : Elsevier
Release : 2018-09-05
ISBN : 0128130393
Language : En, Es, Fr & De

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Book Description :

Late-Stage Fluorination of Bioactive Molecules and Biologically-Relevant Substrates reviews how the use of these techniques on compounds with already known and relevant biological activity can provide new pharmaceutical leads with improved medicinal properties. The fluorination strategies discussed take into account both conventional and novel reagents, including nucleophilic, electrophilic, those of a radical nature, and diverse families of organic compounds, such as (hetero) aromatic rings and aliphatic substrates. Drawing on the authors' expert knowledge, this book provides researchers with a broad set of applicable methods to use in their work. Highlights the latest developments in the field in a concise volume Provides details of key fluorinating reagents across diverse families of organic compounds Explores the current applications and future potential of fluorine in drug development

Nontraditional Activation Methods in Green and Sustainable Applications

Nontraditional Activation Methods in Green and Sustainable Applications Book
Author : Bela Torok,Christian Schaefer
Publisher : Elsevier
Release : 2021-02-28
ISBN : 0128190159
Language : En, Es, Fr & De

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Book Description :

Nontraditional Activation Methods in Green and Sustainable Applications: Microwaves; Ultrasounds; Photo-, Electro- and Mechan-ochemistry and High Hydrostatic Pressure provides a broad overview of non-traditional activation methods to help readers identify and use appropriate approaches in reducing the environmental impact of their work. Sections discuss the fundamental principles of each method and provide examples of their practical use, illustrating their usefulness. Given the importance of expanding laboratory based technologies to the industrial level, chapters that cover both existing and potential industrial and environmental applications are also included. Highlighting the usefulness and adaptability of these methods for a range of practical applications, this book is a practical guide for both those involved with the design and application of synthetic methodologies and those interested in the implementation and impact of green chemistry principles in practice, from synthetic and medicinal chemists, to food developers and environmental policy planners. Discusses, and critically assesses, the advantages of non-traditional activation methods in green and sustainable chemistry applications Features individual chapters written by renowned experts in the field Contains extensive, state-of-the-art reference sections, providing critically filtered information to readers

Organofluorine Chemistry

Organofluorine Chemistry Book
Author : Kalman J. Szabo,Nicklas Selander
Publisher : John Wiley & Sons
Release : 2021-01-05
ISBN : 3527825142
Language : En, Es, Fr & De

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Book Description :

By presenting novel methods for the efficient preparation of fluorinated compounds and their application in pharmaceutical and agrochemical chemistry as well as medicine, this is a valuable source of information for all researchers in academia and industry!

C H and C X Bond Functionalization

C H and C X Bond Functionalization Book
Author : Xavi Ribas
Publisher : Royal Society of Chemistry
Release : 2013
ISBN : 1849735700
Language : En, Es, Fr & De

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Book Description :

Cross-coupling reactions involving C-H and C-X bond functionalisation are commonplace in natural product synthesis and natural products, therapeutic agents, biological probes, and advanced materials. Much attention has been given to understanding the mechanistic strategies used to achieve this, making this a hot topic in recent years. In this edited book, contributions from across the globe examine these strategies, with a particular focus on palladium and copper, as well as iron u an emerging element in this field. Reviewing the recent literature, the book presents an in-depth understanding of the field, guiding the reader to achieving the best synthetic strategies for aromatic functionalisation. Organic and Organometallic chemists, as well as natural product and pharmaceutical scientists, will find this an essential guide to a major transformation currently underway in synthetic chemistry."

Emerging Fluorinated Motifs

Emerging Fluorinated Motifs Book
Author : Dominique Cahard,Jun-An Ma
Publisher : John Wiley & Sons
Release : 2020-04-10
ISBN : 3527824332
Language : En, Es, Fr & De

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Book Description :

A must-have resource for all the researchers working in the organofluorine and related fields This timely two-volume set uniquely focuses on emerging fluorinated motifs beyond R-CF3 and R-F, like R-CF2H, R-OCF3, R-SCF3 and R-SF5. It also offers descriptions of the properties, synthesis, and applications of these emerging fluorinated motifs in order to help readers design new chemical entities, while providing new interest for researchers in organofluorine chemistry and new tools for those in other areas. Emerging Fluorinated Motifs: Synthesis, Properties and Applications begins with a description of carbon-linked fluorine-containing groups that include monofluoromethyl and difluoromethyl groups. It then details combinations of heteroatoms, Oxygen, Sulfur, Selenium, Nitrogen, and Phosphorus with fluorine-containing groups, outlining subsections of the most popular current motifs. Fluoroalkyl ethers, thioethers, and the recent blossoming of the SF5 unit is covered. Other chapters look at: selenium-linked fluorine-containing motifs; construction of N?CF2H, N?CF3, N?CH2CF3 motifs; and the synthesis and applications of P¿Rf-containing molecules. -Focuses on the synthesis, properties, and applications of emerging fluorinated motifs -Covers carbon-linked fluorine-containing motifs, oxygen-linked fluorine-containing motifs, sulfur-linked fluorine-containing motifs, and more -Appeals to academic and industrial researchers working in organic chemistry, medicinal chemistry, food chemistry, and materials science -Edited by world-renowned experts in organofluorine chemistry Emerging Fluorinated Motifs is intended for academic research institutes, university libraries, researchers, graduate students, postdoctors, and researchers in the chemical industry.

Peptide Protein and Enzyme Design

Peptide  Protein and Enzyme Design Book
Author : Anonim
Publisher : Academic Press
Release : 2016-08-27
ISBN : 0128054344
Language : En, Es, Fr & De

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Book Description :

De Novo Enzyme Design, the newest volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume includes the design of metal binding maquettes, insertion of non-natural cofactors, Cu metallopeptides, non-covalent interactions in peptide assemblies, peptide binding and bundling, heteronuclear metalloenzymes, florinated peptides, De Novo imaging agents, and protein-protein interaction. Continues the legacy of this premier serial with quality chapters on de novo enzyme design Represents the newest volume in the Methods in Enzymology series, providing premier, quality chapters authored by leaders in the field Ideal reference for those interested in the study of enzyme design that looks at both structure and mechanism

Journal of the Chemical Society

Journal of the Chemical Society Book
Author : Anonim
Publisher : Unknown
Release : 1994
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Journal of the Chemical Society book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.