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Late Stage Fluorination Of Bioactive Molecules And Biologically Relevant Substrates

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Late Stage Fluorination of Bioactive Molecules and Biologically Relevant Substrates

Late Stage Fluorination of Bioactive Molecules and Biologically Relevant Substrates Book
Author : Al Postigo
Publisher : Unknown
Release : 2018-10
ISBN : 9780128129586
Language : En, Es, Fr & De

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Book Description :

Late Stage Fluorination of Bioactive Molecules and Biologically-Relevant Substrates reviews how the use of these techniques on compounds with already known and relevant biological activity can provide new pharmaceutical leads with improved medicinal properties. The fluorination strategies discussed take into account both conventional and novel reagents, including nucleophilic, electrophilic, those of a radical nature, and diverse families of organic compounds, such as (hetero) aromatic rings and aliphatic substrates. Drawing on the authors' expert knowledge, this book provides researchers with a broad set of applicable methods to use in their work. Highlights the latest developments in the field in a concise volume Provides details of key fluorinating reagents across diverse families of organic compounds Explores the current applications and future potential of fluorine in drug development

Late Stage Fluorination of Bioactive Molecules and Biologically Relevant Substrates

Late Stage Fluorination of Bioactive Molecules and Biologically Relevant Substrates Book
Author : Al Postigo
Publisher : Elsevier
Release : 2018-09-05
ISBN : 0128130393
Language : En, Es, Fr & De

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Book Description :

Late-Stage Fluorination of Bioactive Molecules and Biologically-Relevant Substrates reviews how the use of these techniques on compounds with already known and relevant biological activity can provide new pharmaceutical leads with improved medicinal properties. The fluorination strategies discussed take into account both conventional and novel reagents, including nucleophilic, electrophilic, those of a radical nature, and diverse families of organic compounds, such as (hetero) aromatic rings and aliphatic substrates. Drawing on the authors' expert knowledge, this book provides researchers with a broad set of applicable methods to use in their work. Highlights the latest developments in the field in a concise volume Provides details of key fluorinating reagents across diverse families of organic compounds Explores the current applications and future potential of fluorine in drug development

Nontraditional Activation Methods in Green and Sustainable Applications

Nontraditional Activation Methods in Green and Sustainable Applications Book
Author : Bela Torok,Christian Schaefer
Publisher : Elsevier
Release : 2021-02-28
ISBN : 0128190159
Language : En, Es, Fr & De

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Book Description :

Nontraditional Activation Methods in Green and Sustainable Applications: Microwaves; Ultrasounds; Photo-, Electro- and Mechan-ochemistry and High Hydrostatic Pressure provides a broad overview of non-traditional activation methods to help readers identify and use appropriate approaches in reducing the environmental impact of their work. Sections discuss the fundamental principles of each method and provide examples of their practical use, illustrating their usefulness. Given the importance of expanding laboratory based technologies to the industrial level, chapters that cover both existing and potential industrial and environmental applications are also included. Highlighting the usefulness and adaptability of these methods for a range of practical applications, this book is a practical guide for both those involved with the design and application of synthetic methodologies and those interested in the implementation and impact of green chemistry principles in practice, from synthetic and medicinal chemists, to food developers and environmental policy planners. Discusses, and critically assesses, the advantages of non-traditional activation methods in green and sustainable chemistry applications Features individual chapters written by renowned experts in the field Contains extensive, state-of-the-art reference sections, providing critically filtered information to readers

Principles of Molecular Probe Design and Applications

Principles of Molecular Probe Design and Applications Book
Author : Wellington Pham
Publisher : Springer Nature
Release : 2022-10-28
ISBN : 9811957398
Language : En, Es, Fr & De

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Book Description :

This book describes insight mechanisms for designing molecular probes and methods that these agents can be used for medical diagnosis in preclinical animal models via optical, MRI and PET imaging. The book has a wealth of schemes of synthesis and methods deduced from pioneers in the field, making it possible to immerse into real-world molecular imaging. Written for graduate student training and practitioners, this book will serve as a teaching material and/or reference for anyone interested in exploring the power of chemical synthesis of imaging agents.

Organofluorine Chemistry

Organofluorine Chemistry Book
Author : Kalman J. Szabo,Nicklas Selander
Publisher : John Wiley & Sons
Release : 2021-01-05
ISBN : 3527825142
Language : En, Es, Fr & De

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Book Description :

By presenting novel methods for the efficient preparation of fluorinated compounds and their application in pharmaceutical and agrochemical chemistry as well as medicine, this is a valuable source of information for all researchers in academia and industry!

C H and C X Bond Functionalization

C H and C X Bond Functionalization Book
Author : Xavi Ribas
Publisher : Royal Society of Chemistry
Release : 2013
ISBN : 1849735700
Language : En, Es, Fr & De

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Book Description :

Cross-coupling reactions involving C-H and C-X bond functionalisation are commonplace in natural product synthesis and natural products, therapeutic agents, biological probes, and advanced materials. Much attention has been given to understanding the mechanistic strategies used to achieve this, making this a hot topic in recent years. In this edited book, contributions from across the globe examine these strategies, with a particular focus on palladium and copper, as well as iron û an emerging element in this field. Reviewing the recent literature, the book presents an in-depth understanding of the field, guiding the reader to achieving the best synthetic strategies for aromatic functionalisation. Organic and Organometallic chemists, as well as natural product and pharmaceutical scientists, will find this an essential guide to a major transformation currently underway in synthetic chemistry.

Green Synthetic Approaches for Biologically Relevant Heterocycles

Green Synthetic Approaches for Biologically Relevant Heterocycles Book
Author : Goutam Brahmachari
Publisher : Elsevier
Release : 2021-03-20
ISBN : 0323851304
Language : En, Es, Fr & De

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Book Description :

Green Synthetic Approaches for Biologically Relevant Heterocycles, Second Edition, Volume One: Advanced Synthetic Techniques reviews this significant group of organic compounds within the context of sustainable methods and processes, expanding on the first edition with fully updated coverage and a whole range of new chapters. Volume One explores advanced synthetic techniques, with each chapter presenting in-depth coverage of various green protocols for the synthesis of a wide variety of bioactive heterocycles that are classified on the basis of ring-size and/or the presence of heteroatoms. Techniques covered range from high pressure cycloaddition reactions and microwave irradiation to sustainable one-pot domino reactions. This updated edition is an essential resource on sustainable approaches for academic researchers, R&D professionals, and students working across medicinal, organic, natural product and green chemistry. Provides fully updated coverage of the field of greener heterocycle synthesis Includes new chapters on varied multicomponent reactions, alongside both traditional and novel approaches Presents information in an accessible style with an emphasis on sustainability

Fluorine and Health

Fluorine and Health Book
Author : Alain Tressaud,Gunter Haufe
Publisher : Elsevier
Release : 2008-06-06
ISBN : 9780080558110
Language : En, Es, Fr & De

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Book Description :

Fluorine and Health presents a critical multidisciplinary overview on the contribution of fluorinated compounds to resolve the important global issue of medicinal monitoring and health care. The involved subjects are organized in three thematic parts devoted to Molecular Imaging, Biomedical Materials and Pharmaceuticals. Initially the key-position of partially fluorinated low molecular weight compounds labelled either with the natural 19F-isotope for Magnetic Resonance Imaging (MRI) or labelled with the radioactive [18F]-isotope for Positron Emission Tomography (PET) is highlighted. Both non-invasive methods belong to the most challenging in vivo imaging techniques in oncology, neurology and in cardiology for the diagnosis of diseases having the highest mortality in the industrialized countries. The manifold facets of fluorinated biomaterials range from inorganic ceramics to perfluorinated organic molecules. Liquid perfluorocarbons are suitable for oxygen transport and as potential respiratory gas carriers, while fluorinated polymers are connected to the pathology of blood vessels. Another important issue concerns the application of highly fluorinated liquids in ophthalmology. Moreover, fluorine is an essential trace element in bone mineral, dentine and tooth enamel and is applied for the prophylaxis and treatment of dental caries. The various origins of human exposure to fluoride species is detailed to promote a better understanding of the effect of fluoride species on living organisms. Medicinally relevant fluorinated molecules and their interactions with native proteins are the main focus of the third part. New molecules fluorinated in strategic position are crucial for the development of pharmaceuticals with desired action and optimal pharmacological profile. Among the hundreds of marketed active drug components there are more than 150 fluorinated compounds. The chapters will illustrate how the presence of fluorine atoms alters properties of bioactive compounds at various biochemical steps, and possibly facilitate its emergence as pharmaceuticals. Finally the synthetic potential of a fluorinase, the first C-F bond forming enzyme, is summarized. - New approach of topics involving chemistry, biology and medicinal techniques - Transdisciplinar papers on fluoride products - Importance of fluoride products in health - Updated data on specific topics

Modern Synthesis Processes and Reactivity of Fluorinated Compounds

Modern Synthesis Processes and Reactivity of Fluorinated Compounds Book
Author : Henri Groult,Frederic Leroux,Alain Tressaud
Publisher : Elsevier
Release : 2016-11-04
ISBN : 0128037903
Language : En, Es, Fr & De

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Book Description :

Modern Synthesis Processes and Reactivity of Fluorinated Compounds focuses on the exceptional character of fluorine and fluorinated compounds. This comprehensive work explores examples taken from all classes of fluorine chemistry and illustrates the extreme reactivity of fluorinating media and the peculiar synthesis routes to fluorinated materials. The book provides advanced and updated information on the latest synthesis routes to fluorocompounds and the involved reaction mechanisms. Special attention is given to the unique reactivity of fluorine and fluorinated media, along with the correlation of those properties to valuable applications of fluorinated compounds. Contains quality content edited, and contributed, by leading scholars in the field Presents applied guidance on the preparation of original fluorinated compounds, potentially transferable from the lab scale to industrial applications Provides practical synthesis information for a wide audience interested in fluorine compounds in many branches of chemistry, materials science, and physics

Fluorination

Fluorination Book
Author : Jinbo Hu,Teruo Umemoto
Publisher : Springer
Release : 2020-08-12
ISBN : 9789811038952
Language : En, Es, Fr & De

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Book Description :

This volume reviews the recent advances in formation of C-F bonds and X-F bonds (X = heteroatom) to produce useful fluorinated molecules for pharmaceuticals, materials and more. Reactions and methods associated with fluorination, including monofluorination, difluorination, trifluorination and other polyfluorination that have emerged within the past few years are systematically discussed. With contributions from front-line researchers in this field from both academia and industry, this book provides a valuable resource for scholars, graduate students as well as professionals.

Advances in Organic Synthesis

Advances in Organic Synthesis Book
Author : Atta-ur-Rahman,Kenneth K. Laali
Publisher : Bentham Science Publishers
Release : 2011-01-10
ISBN : 1608051986
Language : En, Es, Fr & De

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Book Description :

"The volume focuses on recent advances in organofluorine chemistry directed towards selective fluorine introduction into various target molecules, employing both traditional and contemporary, electrophilic and nucleophilic, fluorinating agents. It brings t"

Advanced Inorganic Fluorides Synthesis Characterization and Applications

Advanced Inorganic Fluorides  Synthesis  Characterization and Applications Book
Author : T. Nakajima,B. Žemva,A. Tressaud
Publisher : Elsevier
Release : 2000-05-12
ISBN : 9780080525488
Language : En, Es, Fr & De

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Book Description :

This book summarizes recent progresses in inorganic fluorine chemistry. Highlights include new aspects of inorganic fluorine chemistry, such as new synthetic methods, structures of new fluorides and oxide fluorides, their physical and chemical properties, fluoride catalysts, surface modifications of inorganic materials by fluorination process, new energy conversion materials and industrial applications. Fluorine has quite unique properties (highest electronegativity; very small polarizability). In fact, fluorine is so reactive that it forms fluorides with all elements except with the lightest noble gases helium, neon and argon. Originally, due to its high reactivity, fluoride chemistry faced many technical difficulties and remained undeveloped for many years. Now, however, a large number of fluorine-containing materials are currently produced for practical uses on an industrial scale and their applications are rapidly extending to many fields. Syntheses and structure analyses of thermodynamically unstable high-oxidation-state fluorides have greatly contributed to inorganic chemistry in this decade. Fluoride catalysts and surface modifications using fluorine are developing a new field of fluorine chemistry and will enable new syntheses of various compounds. The research on inorganic fluorides is now contributing to many chemical energy conversion processes such as lithium batteries. Furthermore, new theoretical approaches to determining the electronic structures of fluorine compounds are also progressing. On the industrial front, the use of inorganic fluorine compounds is constantly increasing, for example, in semi-conductor industry. "Advanced Inorganic Fluorides: Synthesis, Characterization and Applications" focuses on these new features in inorganic fluorine chemistry and its industrial applications. The authors are outstanding experts in their fields, and the contents of the book should prove to be of valuable assistance to all chemists, graduates, students and researchers in the field of fluorine chemistry.

Pincer Compounds

Pincer Compounds Book
Author : David Morales-Morales
Publisher : Elsevier
Release : 2018-04-11
ISBN : 0128129328
Language : En, Es, Fr & De

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Book Description :

Pincer Compounds: Chemistry and Applications offers valuable state-of-the-art coverage highlighting highly active areas of research—from mechanistic work to synthesis and characterization. The book focuses on small molecule activation chemistry (particularly H2 and hydrogenation), earth abundant metals (such as Fe), actinides, carbene-pincers, chiral catalysis, and alternative solvent usage. The book covers the current state of the field, featuring chapters from renowned contributors, covering four continents and ranging from still-active pioneers to new names emerging as creative strong contributors to this fascinating and promising area. Over a decade since the publication of Morales-Morales and Jensen’s The Chemistry of Pincer Compounds (Elsevier 2007), research in this unique area has flourished, finding a plethora of applications in almost every single branch of chemistry—from their traditional application as very robust and active catalysts all the way to potential biological and pharmaceutical applications. Describes the chemistry and applications of this important class of organometallic and coordination compounds Includes contributions from global leaders in the field, featuring pioneers in the area as well as emerging experts conducting exciting research on pincer complexes Highlights areas of promising and active research, including small molecule activation, earth abundant metals, and actinide chemistry

Fluorine containing Amino Acids

Fluorine containing Amino Acids Book
Author : Valery P. Kukhar,Valeriĭ Pavlovich Kukharʹ,Vadim A. Soloshonok
Publisher : John Wiley & Sons Incorporated
Release : 1995-04-06
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

In recent years, organo-fluorine chemistry has made a marked impact on the design and synthesis of a large variety of biologically active molecules, such as steroids, carbohydrates, amines, amino acids, peptides and other natural products. Naturally occurring amino acids play a pivotal role in living systems, and therefore synthetic fluorine-containing amino acids have been of significant interest to researchers working towards the understanding and modification of physiological processes. Fluorine-containing Amino Acids: is the first volume devoted to the synthesis and properties of fluorine-containing amino acids pays special attention to the preparation of enantiomerically pure acids (which are essential to the modern pharmaceutical industry) deals with a rapidly expanding field of research has been written by experienced researchers who are responsible for many developments in the field highlights the interdisciplinary nature of this topic Fluorine-containing Amino Acids is the only dedicated reference in this subject and will be essential for researchers in synthetic organic, peptide, natural product, and medicinal chemistry and biochemistry.

Trends on the Role of PET in Drug Development

Trends on the Role of PET in Drug Development Book
Author : Philip H. Elsinga
Publisher : World Scientific
Release : 2012
ISBN : 981431773X
Language : En, Es, Fr & De

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Book Description :

Drug development is very expensive and a fight against time. PET offers possibilities to speed up this process by adding unique in vivo information on pharmacokinetics/dynamics of a drug at an early stage. This information can help decision makers to move the drug in the drug development process or to decide to stop further developments. This unique and complete book highlights the different ways PET can be used and describes the latest trends in the various disciplines within nuclear medicine to further improve methodologies and increase the number of tools to accelerate drug development. Various topics within tracer development, instrumentation, data analysis and many clinical and preclinical topics are described by leading scientists from industry and academia.

Carbon Alloys

Carbon Alloys Book
Author : E. Yasuda,Michio Inagaki,K. Kaneko,M. Endo,A. Oya,Y. Tanabe
Publisher : Elsevier
Release : 2003-03-05
ISBN : 9780080528533
Language : En, Es, Fr & De

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Book Description :

In recent years the Japanese have funded a comprehensive study of carbon materials which incorporate other elements including boron, nitrogen and fluorine, hence the title of the project "Carbon Alloys". Coined in 1992, the phrase "Carbon Alloys" can be applied to those materials mainly composed of carbon materials in multi-component systems. The carbon atoms of each component have a physical and/or chemical interactive relationship with other atoms or compounds. The carbon atoms of the components may have different hybrid bonding orbitals to create quite different carbon components. Eiichi Yasuda and his team consider the definition of Carbon Alloys, present the results of the Carbon Alloys projects, describe typical Carbon Alloys and their uses, discuss recent techniques for their characterization, and finally, illustrate potential applications and future developments for Carbon Alloy science. The book contains over thirty chapters on these studies from as many researchers. The most modern of techniques, particularly in the area of spectroscopy, were used as diagnostic tools, and many of these are applicable to pure carbons also. Porosity in carbons received considerable attention.

Emerging Fluorinated Motifs 2 Volume Set

Emerging Fluorinated Motifs  2 Volume Set Book
Author : Dominique Cahard,Jun-An Ma
Publisher : John Wiley & Sons
Release : 2020-07-13
ISBN : 3527346813
Language : En, Es, Fr & De

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Book Description :

A must-have resource for all the researchers working in the organofluorine and related fields This timely two-volume set uniquely focuses on emerging fluorinated motifs beyond R-CF3 and R-F, like R-CF2H, R-OCF3, R-SCF3 and R-SF5. It also offers descriptions of the properties, synthesis, and applications of these emerging fluorinated motifs in order to help readers design new chemical entities, while providing new interest for researchers in organofluorine chemistry and new tools for those in other areas. Emerging Fluorinated Motifs: Synthesis, Properties and Applications begins with a description of carbon-linked fluorine-containing groups that include monofluoromethyl and difluoromethyl groups. It then details combinations of heteroatoms, Oxygen, Sulfur, Selenium, Nitrogen, and Phosphorus with fluorine-containing groups, outlining subsections of the most popular current motifs. Fluoroalkyl ethers, thioethers, and the recent blossoming of the SF5 unit is covered. Other chapters look at: selenium-linked fluorine-containing motifs; construction of N?CF2H, N?CF3, N?CH2CF3 motifs; and the synthesis and applications of P¿Rf-containing molecules. -Focuses on the synthesis, properties, and applications of emerging fluorinated motifs -Covers carbon-linked fluorine-containing motifs, oxygen-linked fluorine-containing motifs, sulfur-linked fluorine-containing motifs, and more -Appeals to academic and industrial researchers working in organic chemistry, medicinal chemistry, food chemistry, and materials science -Edited by world-renowned experts in organofluorine chemistry Emerging Fluorinated Motifs is intended for academic research institutes, university libraries, researchers, graduate students, postdoctors, and researchers in the chemical industry.

Amino Acids Peptides and Proteins Volume 44

Amino Acids  Peptides and Proteins Volume 44 Book
Author : Maxim Ryadnov,Ferenc Hudecz
Publisher : Royal Society of Chemistry
Release : 2020-12-08
ISBN : 1788016890
Language : En, Es, Fr & De

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Book Description :

Compiled by leading researchers, Amino Acids, Peptides and Proteins is a broad ranging title comprising comprehensive and critical reviews of significant developments at the biology and chemistry interface.

Arene Chemistry

Arene Chemistry Book
Author : Jacques Mortier
Publisher : John Wiley & Sons
Release : 2015-11-30
ISBN : 1118754980
Language : En, Es, Fr & De

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Book Description :

Organized to enable students and synthetic chemists to understand and expand on aromatic reactions covered in foundation courses, the book offers a thorough and accessible mechanistic explanation of aromatic reactions involving arene compounds. • Surveys methods used for preparing arene compounds and their transformations • Connects reactivity and methodology with mechanism • Helps readers apply aromatic reactions in a practical context by designing syntheses • Provides essential information about techniques used to determine reaction mechanisms

Bioactive Heterocycles II

Bioactive Heterocycles II Book
Author : Shoji Eguchi
Publisher : Springer
Release : 2007-10-08
ISBN : 354072592X
Language : En, Es, Fr & De

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Book Description :

With contributions by numerous experts