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Key Chiral Auxiliary Applications

Key Chiral Auxiliary Applications Book
Author : Gregory Roos
Publisher : Academic Press
Release : 2014-02-20
ISBN : 9780124170346
Language : En, Es, Fr & De

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Book Description :

The Compendium is a detailed compilation of chiral auxiliaries which are used in the field of organic chemistry to direct "asymmetric synthesis". A molecule is called chiral because it can have two "enantiomers" -- like left and right-handed molecules. An enantiomer is either of two molecules of the same chemical composition that are mirror images of each other but not identical. A "chiral auxiliary" is an aid / auxiliary used to specifically produce either the left or right enantiomer of the chosen molecule, as desired. In this comprehesive reference source, industrial chemists can make informed selections of an auxiliary for a specific application. It is fully cross-referenced to enable the comparative selection of auxiliaries. The work includes over 13,000 auxiliary reaction applications with complete reaction details of the synthetic routes, reagents, and primary literature references. Key Features * This remarkable major reference work is the first such compilation and represents the only total source for the diverse applications of auxiliaries * Thoroughly cross-referenced to enable comparative

Key Chiral Auxiliary Applications

Key Chiral Auxiliary Applications Book
Author : Gregory Roos
Publisher : Academic Press
Release : 2014-01-20
ISBN : 012417115X
Language : En, Es, Fr & De

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Book Description :

Key Chiral Auxiliary Applications, Second Edition is a detailed compilation of chiral auxiliary applications organized by type of transformation. Continuing from the most important and relevant auxiliaries described in its predecessor, the three-volume set Compendium of Chiral Auxiliary Applications (2001), as well as advances in the field, the book provides a vital and timely resource for chemists in the field. Each reaction class includes a series of tables and graphical abstracts of real reactions from the literature and patents to enable easy review and comparison of results. This anticipated edition is based on a screening of nearly 40,000 auxiliary reaction applications, with details supplied for the more than 13,000 selected representative entries: synthetic route, reagents, yields, diastereomeric/enantiomeric excesses, and characterization data. Updated and streamlined with more than 60% new material, Key Chiral Auxiliary Applications provides valuable guidance and reliable content for selecting the best auxiliary for a specific asymmetric synthetic transformation. Provides a comprehensive compilation based on nearly 40,000 diverse applications of chiral auxiliaries for selecting the best synthetic route to optically pure compounds Contains over 60% new material with 13,000+ auxiliary applications categorized by reaction type, with reaction details and chemical and optical yields in one unique resource

Compendium of Chiral Auxiliary Applications Three Volume Set

Compendium of Chiral Auxiliary Applications  Three Volume Set Book
Author : Gregory Roos
Publisher : Academic Press
Release : 2002-01-04
ISBN : 9780125953498
Language : En, Es, Fr & De

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Book Description :

The Compendium is a detailed compilation of chiral auxiliaries which are used in the field of organic chemistry to direct "asymmetric synthesis". A molecule is called chiral because it can have two "enantiomers" -- like left and right-handed molecules. An enantiomer is either of two molecules of the same chemical composition that are mirror images of each other but not identical. A "chiral auxiliary" is an aid / auxiliary used to specifically produce either the left or right enantiomer of the chosen molecule, as desired. In this comprehesive reference source, industrial chemists can make informed selections of an auxiliary for a specific application. It is fully cross-referenced to enable the comparative selection of auxiliaries. The work includes over 13,000 auxiliary reaction applications with complete reaction details of the synthetic routes, reagents, and primary literature references. Key Features * This remarkable major reference work is the first such compilation and represents the only total source for the diverse applications of auxiliaries * Thoroughly cross-referenced to enable comparative

Real Science in Clear English

Real Science in Clear English Book
Author : Cathryn Roos,Gregory Roos
Publisher : Springer
Release : 2019-08-07
ISBN : 9811378207
Language : En, Es, Fr & De

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Book Description :

This book is a timely go-to resource for any professionals wishing to communicate with the growing number of readers whose first language is not English. It highlights the potential language difficulties these readers face, and provides guidelines and tools for overcoming them. The guidelines show how to convey complicated information clearly without affecting the integrity of the subject matter, while the practical ‘before’ and ‘after’ examples clearly illustrate how using these guidelines and improves scientific texts. The book also includes text evaluation tools that allow writers to rapidly assess the readability of their materials. It is based on theory and the authors’ extensive experience in producing highly readable English texts for L2 readers who struggle with materials that were originally prepared for L1 readers.

Advances in Heterocyclic Chemistry

Advances in Heterocyclic Chemistry Book
Author : Anonim
Publisher : Academic Press
Release : 2017-03-19
ISBN : 0128119934
Language : En, Es, Fr & De

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Book Description :

Advances in Heterocyclic Chemistry is the definitive series in the field—one of great importance to organic chemists, polymer chemists, and many biological scientists. Because biology and organic chemistry increasingly intersect, the associated nomenclature is being used more frequently in explanations. Written by established authorities in the field from around the world, this comprehensive review combines descriptive synthetic chemistry and mechanistic insight to yield an understanding of how chemistry drives the preparation and useful properties of heterocyclic compounds. Serves as the go-to reference for organic chemists, polymer chemists, and many biological scientists Provides the latest comprehensive reviews written by established authorities in the field Combines descriptive synthetic chemistry and mechanistic insight to show how chemistry drives the preparation and useful properties of heterocyclic compounds

Principles and Applications of Stereochemistry

Principles and Applications of Stereochemistry Book
Author : Michael North
Publisher : CRC Press
Release : 1998-10-23
ISBN : 9780748739943
Language : En, Es, Fr & De

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Book Description :

A thorough understanding of stereochemistry is essential for the comprehension of almost all aspects of modern organic chemistry. It is also of great significance in many biochemical and medicinal disciplines, since the stereoisomers of a compound can have dramatically different biological properties. This text explains how the different properties of stereoisomers of a compound arise, and what processes can be used to prepare and analyze stereoisomerically pure compounds. It also presents prominent coverage of the stereochemistry of inorganic and organometallic compounds, which is likely to increase in importance, as these compounds are used as symmetric catalysts in asymmetric synthesis. Modern stereochemical terminology is used throughout, although reference is also made to older terms which are still widely used. A set of problems at the end of each chapter aims to further the reader's understanding of how the content can be applied. The book is designed mainly as a textbook for undergraduate students and as a reference source for more advanced levels, but is also intended for academic and professional organic chemists.

Comprehensive Organic Chemistry Experiments for the Laboratory Classroom

Comprehensive Organic Chemistry Experiments for the Laboratory Classroom Book
Author : Carlos A M Afonso,Nuno R Candeias,Dulce Pereira Simão,Alexandre F Trindade,Jaime A S Coelho,Bin Tan,Robert Franzén
Publisher : Royal Society of Chemistry
Release : 2020-08-28
ISBN : 183916297X
Language : En, Es, Fr & De

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Book Description :

This expansive and practical textbook contains organic chemistry experiments for teaching in the laboratory at the undergraduate level covering a range of functional group transformations and key organic reactions.The editorial team have collected contributions from around the world and standardized them for publication. Each experiment will explore a modern chemistry scenario, such as: sustainable chemistry; application in the pharmaceutical industry; catalysis and material sciences, to name a few. All the experiments will be complemented with a set of questions to challenge the students and a section for the instructors, concerning the results obtained and advice on getting the best outcome from the experiment. A section covering practical aspects with tips and advice for the instructors, together with the results obtained in the laboratory by students, has been compiled for each experiment. Targeted at professors and lecturers in chemistry, this useful text will provide up to date experiments putting the science into context for the students.

Strategic Applications of Named Reactions in Organic Synthesis

Strategic Applications of Named Reactions in Organic Synthesis Book
Author : Laszlo Kurti,Barbara Czako
Publisher : Elsevier
Release : 2005-04-29
ISBN : 0080575412
Language : En, Es, Fr & De

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Book Description :

Kurti and Czako have produced an indispensable tool for specialists and non-specialists in organic chemistry. This innovative reference work includes 250 organic reactions and their strategic use in the synthesis of complex natural and unnatural products. Reactions are thoroughly discussed in a convenient, two-page layout--using full color. Its comprehensive coverage, superb organization, quality of presentation, and wealth of references, make this a necessity for every organic chemist. * The first reference work on named reactions to present colored schemes for easier understanding * 250 frequently used named reactions are presented in a convenient two-page layout with numerous examples * An opening list of abbreviations includes both structures and chemical names * Contains more than 10,000 references grouped by seminal papers, reviews, modifications, and theoretical works * Appendices list reactions in order of discovery, group by contemporary usage, and provide additional study tools * Extensive index quickly locates information using words found in text and drawings

Journal of Research of the National Institute of Standards and Technology

Journal of Research of the National Institute of Standards and Technology Book
Author : Anonim
Publisher : Unknown
Release : 1991-10
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Journal of Research of the National Institute of Standards and Technology book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Light Metals Advances in Research and Application 2011 Edition

Light Metals  Advances in Research and Application  2011 Edition Book
Author : Anonim
Publisher : ScholarlyEditions
Release : 2012-01-09
ISBN : 1464920834
Language : En, Es, Fr & De

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Book Description :

Light Metals: Advances in Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Light Metals. The editors have built Light Metals: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Light Metals in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Light Metals: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Chiral Reagents for Asymmetric Synthesis

Chiral Reagents for Asymmetric Synthesis Book
Author : Leo A. Paquette
Publisher : John Wiley & Sons
Release : 2003-08-01
ISBN : 9780470856253
Language : En, Es, Fr & De

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Book Description :

Derived from the renowned, Encyclopedia of Reagents for Organic Synthesis (EROS), the related editors have created a new handbook which focuses on chiral reagents used in asymmetric synthesis and is designed for the chemist at the bench. This new handbook follows the same format as the Encyclopedia, including an introduction and an alphabetical arrangement of the reagents. As chiral reagents are the key for the successful asymmetric synthesis, choosing the right reagents is essential, in this handy reference the editors give details on how to prepare, store and use the reagents as well as providing key reactions to demonstrate where reagents have been successfully used. Comprehensive information on 226 reagents Covers 64 reagents which were not included in EROS All information in one easy to use volume – at an affordable price All reagents included will be added to e-EROS – please visit the site where you can gain access to over 50,000 reactions and 3,800 of the most frequently consulted reagents. Visit: www.interscience.wiley.com/eros

Process Chemistry in the Pharmaceutical Industry

Process Chemistry in the Pharmaceutical Industry Book
Author : Kumar Gadamasetti
Publisher : CRC Press
Release : 1999-05-06
ISBN : 1482276097
Language : En, Es, Fr & De

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Book Description :

Providing guidance for chemists and other scientists entering pharmaceutical discovery and development, this up-to-the-minute reference presents contributions from an international group of nearly 50 renowned researchers-offering a solid grounding in synthetic and physical organic chemistry, and clarifying the roles of various special

Synthetic Methods in Drug Discovery

Synthetic Methods in Drug Discovery Book
Author : David C. Blakemore,Paul M. Doyle,Yvette M. Fobian
Publisher : Royal Society of Chemistry
Release : 2016-05-30
ISBN : 1782627863
Language : En, Es, Fr & De

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Book Description :

The number of available synthetic methods can be overwhelming. In order to create novel motifs and templates which confer new and potentially valuable drug-like properties, it is important to know which synthetic methodologies will give the best results. Similarly, which methodologies are used to progress potential drug candidates from leads through the development process? What are the current industrial research problems and how can they be resolved in an industrial setting? This book highlights key methods that have real impact in drug discovery and facilitate delivery of drug molecules. Synthetic Methods in Drug Discovery Volume 1 focuses on the hugely important area of transition metal mediated methods used in industry. Current methods of importance such as the Suzuki-Miyaura coupling, Buchwald-Hartwig couplings and CH activation are discussed. In addition, exciting emerging areas such as decarboxylative coupling, and the uses of iron and nickel in coupling reactions are also covered. This book provides both academic and industrial perspectives on some key reactions giving the reader an excellent overview of the techniques used in modern synthesis. Reaction types are conveniently framed in the context of their value to industry and the challenges and limitations of methodologies are discussed with relevant illustrative examples. Edited and authored by leading scientists from both academia and industry, this book will be a valuable reference for all chemists involved in drug discovery as well as postgraduate students in medicinal chemistry.

Methods and Applications of Cycloaddition Reactions in Organic Syntheses

Methods and Applications of Cycloaddition Reactions in Organic Syntheses Book
Author : Nagatoshi Nishiwaki
Publisher : John Wiley & Sons
Release : 2013-12-17
ISBN : 1118778200
Language : En, Es, Fr & De

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Book Description :

Advanced tools for developing new functional materials andapplications in chemical research, pharmaceuticals, and materialsscience Cycloadditions are among the most useful tools for organicchemists, enabling them to build carbocyclic and heterocyclicstructures. These structures can then be used to develop a broadrange of functional materials, including pharmaceuticals,agrochemicals, dyes, and optics. With contributions from aninternational team of leading experts and pioneers in cycloadditionchemistry, this book brings together and reviews recent advances,trends, and emerging research in the field. Methods and Applications of Cycloaddition Reactions inOrganic Syntheses focuses on two component cycloadditions, withchapters covering such topics as: N1 unit transfer reaction to C–C doublebonds [3+2] Cycloaddition of α, β-unsaturatedmetal-carbene complexes Formal [3+3] cycloaddition approach to natural productsynthesis Development of new methods for the construction of heterocyclesbased on cycloaddition reaction of 1,3-dipoles Cycloreversion approach for preparation of largeπ-conjugated compounds Transition metal-catalyzed or mediated [5+1]cycloadditions Readers will learn methods for seamlessly executing importantreactions such as Diels-Alder and stereoselective dipolar reactionsin order to fabricate heterocyclic compounds, natural products, andfunctional molecules. The book not only features cutting-edgetopics, but also important background information, such as thecontributors’ process for developing new methodologies, tohelp novices become fully adept in the field. References at the endof each chapter lead to original research papers and reviews forfacilitating further investigation of individual topics. Covering the state of the science and technology, Methods andApplications of Cycloaddition Reactions in Organic Synthesesenables synthetic organic chemists to advance their research anddevelop new functional materials and applications in chemicalresearch, pharmaceuticals, and materials science.

Enantioselective Chemical Synthesis

Enantioselective Chemical Synthesis Book
Author : Elias J. Corey,Laszlo Kurti
Publisher : Elsevier
Release : 2013-10-23
ISBN : 0128001518
Language : En, Es, Fr & De

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Book Description :

Written by world-renowned and best-selling experts, Nobel Laureate E. J. Corey and Laszlo Kurti, Enantioselective Chemical Synthesis offers an authoritative and comprehensive overview of the field’s progress; the processes and tools for key formations; future development for complex, stereocontrolled (enantiomeric or diastereoisomeric) molecules; and valuable examples of multi-step syntheses. Utilizing a color-coded scheme to illustrate chemical transformations, Enantioselective Chemical Synthesis provides clear explanation and guidance through vital asymmetrical syntheses and insight into the next steps for the field. Researchers, professionals, and academics will benefit from this valuable, thorough, and unique resource. In Part I, the authors present clearly, comprehensively and concisely the most useful enantioselective processes available to synthetic chemists. Part II provides an extensive discussion of the most logical ways to apply these new enantioselective methods to the planning of syntheses of stereochemically complex molecules. This hitherto neglected area is essential for the advancement of enantioselective synthesis to a more rational and powerful level. Part III describes in detail many reaction sequences which have been used successfully for the construction of a wide variety of complex target molecules Clearly explains stereochemical synthesis in theory and practice Provides a handy tool box for scientists wishing to understand and apply chiral chemical synthesis Describes almost 50 real life examples of asymmetric synthesis in practice and examines how the chiral centers were introduced at key synthetic stages

Handbook of Chiral Chemicals Second Edition

Handbook of Chiral Chemicals  Second Edition Book
Author : David Ager
Publisher : CRC Press
Release : 2005-10-21
ISBN : 9781420027303
Language : En, Es, Fr & De

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Book Description :

As pharmaceutical companies look to develop single enantiomers as drug candidates, chemists are increasingly faced with the problems associated with this subclass of organic synthesis. "The Handbook of Chiral Chemicals, Second Edition" highlights the problems associated with the production of chiral compounds on a commercial scale. The handbook first elaborates upon starting materials obtained from a 'chiral pool', which can be derived from natural products. Then it explains methods and reactions that can introduce or influence stereogenic centers, particularly asymmetric hydrogenations, oxidations, pericyclic reactions, and enzymatic methods.While hydrogenations have been the most widely employed approach for the large-scale synthesis of several commercial compounds, the search for the ideal catalyst has consistently led researchers to enzymes present in biological systems. Several chapters concentrate on understanding how to manipulate enzymes for catalyzing new reactions for taking new substrates. Other significant topics include chiral auxiliaries, chromatographic techniques, enantiomers-specific reactions, and resolution. This second edition updates all its chapters, illustrating the speed of development in this field, and features new chapters that highlight successful approaches in an industrial setting. "The Handbook of Chiral Chemicals, Second Edition" is a guide to advances in the field that result in more efficient and cost-effective synthesis of chiral chemicals.

Handbook of Reagents for Organic Synthesis

Handbook of Reagents for Organic Synthesis Book
Author : Tomislav Rovis
Publisher : John Wiley & Sons
Release : 2016-10-17
ISBN : 1119061008
Language : En, Es, Fr & De

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Book Description :

Spurred by the desire to make chemistry a sustainable and "greener" technology, the field of organocatalysis has grown to become one of the most important areas in synthetic organic chemistry. Organic catalysts can often replace potentially toxic metal catalysts and allow reactions to proceed under mild reaction conditions, thereby saving energy costs and rendering chemical processes inherently safer. More importantly perhaps, organocatalysis offers a complementary reactivity in many instances leading to increased versatility. This Handbook describes 126 key reagents for organocatalytic reactions and will be especially useful for professionals in the area of sustainable chemistry, medicinal research, as well as synthetic organic chemists working in academia and the pharmaceutical industry. All the information compiled in this volume is also available in electronic format on Wiley Online Library. The 126 reagents represented here are but a small fraction of the ca. 5,000 reagents available in the electronic Encyclopedia of Reagents for Organic Synthesis (e-EROS). e-EROS offers various search interfaces to locate reagents of interest, including chemical structure, substructure and reactions search modes. e-EROS is updated regularly with new and updated entries.

Bioreactor Engineering Research and Industrial Applications I

Bioreactor Engineering Research and Industrial Applications I Book
Author : Qin Ye,Jie Bao,Jian-Jiang Zhong
Publisher : Springer
Release : 2016-01-08
ISBN : 3662491613
Language : En, Es, Fr & De

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Book Description :

This book review series presents current trends in modern biotechnology. The aim is to cover all aspects of this interdisciplinary technology where knowledge, methods and expertise are required from chemistry, biochemistry, microbiology, genetics, chemical engineering and computer science. Volumes are organized topically and provide a comprehensive discussion of developments in the respective field over the past 3-5 years. The series also discusses new discoveries and applications. Special volumes are dedicated to selected topics which focus on new biotechnological products and new processes for their synthesis and purification. In general, special volumes are edited by well-known guest editors. The series editor and publisher will however always be pleased to receive suggestions and supplementary information. Manuscripts are accepted in English.

Lactams Unique Structures of Distinction for Novel Molecules

   Lactams  Unique Structures of Distinction for Novel Molecules Book
Author : Bimal K. Banik
Publisher : Springer
Release : 2012-09-28
ISBN : 3642331882
Language : En, Es, Fr & De

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Book Description :

I. Ojima • E. S. Zuniga • J. D. Seitz: Advances in the Use of Enantiopure β-Lactams for the Synthesis of Biologically Active Compounds of Medicinal Interests.- I. Fernández • Miguel A. Sierra: β -Lactams from Fischer Carbene Complexes: Scope, Limitations, and Reaction Mechanism.- Bablee Mandal • Basudeb Basu: Synthesis of β-Lactams Through Alkyne–Nitrone Cycloadditions.- T. T. Tidwell: Preparation of Bis-β-Lactams by Ketene–Imine Cycloadditions.- Edward Turos: The Chemistry and Biology of N-Thiolated β-Lactams.- Indrani Banik • Bimal K. Banik: Synthesis of β-Lactams and Their Chemical Manipulations Via Microwave-Induced Reactions.

Applications of Transition Metal Catalysis in Drug Discovery and Development

Applications of Transition Metal Catalysis in Drug Discovery and Development Book
Author : Matthew L. Crawley,Barry M. Trost
Publisher : John Wiley & Sons
Release : 2012-07-03
ISBN : 0470631325
Language : En, Es, Fr & De

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Book Description :

This book focuses on the drug discovery and development applications of transition metal catalyzed processes, which can efficiently create preclinical and clinical drug candidates as well as marketed drugs. The authors pay particular attention to the challenges of transitioning academically-developed reactions into scalable industrial processes. Additionally, the book lays the groundwork for how continued development of transition metal catalyzed processes can deliver new drug candidates. This work provides a unique perspective on the applications of transition metal catalysis in drug discovery and development – it is a guide, a historical prospective, a practical compendium, and a source of future direction for the field.