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Isocoumarin Thiaisocoumarin And Phosphaisocoumarin

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Isocoumarin Thiaisocoumarin and Phosphaisocoumarin

Isocoumarin  Thiaisocoumarin and Phosphaisocoumarin Book
Author : Sarbani Pal,Manojit Pal
Publisher : Elsevier
Release : 2018-10-16
ISBN : 0128154462
Language : En, Es, Fr & De

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Book Description :

Isocoumarin, Thiaisocoumarin and Phosphaisocoumarin: Natural Occurrences, Synthetic Approaches and Pharmaceutical Applications gives an overview of the various aspects of this class of heterocycle, with a major focus on synthesis and biological activity. Aromatic δ lactones or isocoumarins with thiaisocoumarins, phosphaisocoumarins and a-pyranone fused with a heteroaryl ring constitute an important class of heterocyclic compounds. This book provides the methods applied for the synthesis of thiaisocoumarins, phosphaisocoumarins, and a-pyranone fused with a heteroaryl ring. It is useful to medicinal and natural product chemists who want to synthesize target molecules and develop cutting-edge technologies to provide better solutions to researchers. Features an overview of isocoumarins and their role in pharmaceutical research Presents a template for the design, discovery and development of new and potential drugs in various therapeutic areas Includes comprehensive coverage of the synthesis of isocoumarins, from traditional methods, to transition metal catalyzed methods Looks at future applications for these important compounds in the areas of drug discovery and pharmaceutical research

Comprehensive Natural Products III

Comprehensive Natural Products III Book
Author : Anonim
Publisher : Elsevier
Release : 2020-07-22
ISBN : 0081026919
Language : En, Es, Fr & De

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Book Description :

Comprehensive Natural Products III, Third Edition, updates and complements the previous two editions, including recent advances in cofactor chemistry, structural diversity of natural products and secondary metabolites, enzymes and enzyme mechanisms and new bioinformatics tools. Natural products research is a dynamic discipline at the intersection of chemistry and biology concerned with isolation, identification, structure elucidation, and chemical characteristics of naturally occurring compounds such as pheromones, carbohydrates, nucleic acids and enzymes. This book reviews the accumulated efforts of chemical and biological research to understand living organisms and their distinctive effects on health and medicine and to stimulate new ideas among the established natural products community. Provides readers with an in-depth review of current natural products research and a critical insight into the future direction of the field Bridges the gap in knowledge by covering developments in the field since the second edition published in 2010 Split into 7 sections on key topics to allow students, researchers and professionals to find relevant information quickly and easily Ensures that the knowledge within is easily understood by and applicable to a large audience

Tellurium in Organic Synthesis

Tellurium in Organic Synthesis Book
Author : Nicola Petragnani,Hélio A. Stefani
Publisher : Academic Press
Release : 2007
ISBN : 9780080453101
Language : En, Es, Fr & De

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Book Description :

The increasing number of publications that use tellurium clearly demonstrates the important role of tellurium compounds as unique and powerful tools in a broad range of organic chemical manipulations, often characterized by their selective behavior. Tellurium in Organic Synthesis provides an overview of the principal aspects of organic tellurium chemistry. Many chapters have been enriched and updated in this second edition. New chapters include overviews of toxicology and pharmacology and a review on the preparation and reactivity of several tellurium heterocycles. The first part of the book focuses on the preparation of selected inorganic tellurium compounds and on the main classes of organotellurium compounds. The second part, and main interest of the book, details the use of these inorganic and organic compounds as reagents to perform specific organic manipulations and synthesis. Reactions covered include reduction, formation and reaction of anionic species, deprotection, tellurium cyclizations, formation of alkenes, use of vinyllic tellurides, free radical chemistry, transmetallations, and removal of tellurium. * Overview of inorganic and organic tellurium chemistry * Synthetic applications of tellurium compounds * All topics accompanied by detailed experimental procedures

Strategies and Tactics in Organic Synthesis

Strategies and Tactics in Organic Synthesis Book
Author : Michael Harmata
Publisher : Academic Press
Release : 2004-11-17
ISBN : 9780124502840
Language : En, Es, Fr & De

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Book Description :

This title provides a forum for investigators to discuss their approach to the science and art of organic synthesis in a unique way. There are stories that vividly demonstrate the power of the human endeavour known as organic synthesis and the creativity and tenacity of its practitioners.

Principles of Organic Chemistry

Principles of Organic Chemistry Book
Author : Robert J. Ouellette,J. David Rawn
Publisher : Academic Press
Release : 2015-02-13
ISBN : 0128026340
Language : En, Es, Fr & De

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Book Description :

Class-tested and thoughtfully designed for student engagement, Principles of Organic Chemistry provides the tools and foundations needed by students in a short course or one-semester class on the subject. This book does not dilute the material or rely on rote memorization. Rather, it focuses on the underlying principles in order to make accessible the science that underpins so much of our day-to-day lives, as well as present further study and practice in medical and scientific fields. This book provides context and structure for learning the fundamental principles of organic chemistry, enabling the reader to proceed from simple to complex examples in a systematic and logical way. Utilizing clear and consistently colored figures, Principles of Organic Chemistry begins by exploring the step-by-step processes (or mechanisms) by which reactions occur to create molecular structures. It then describes some of the many ways these reactions make new compounds, examined by functional groups and corresponding common reaction mechanisms. Throughout, this book includes biochemical and pharmaceutical examples with varying degrees of difficulty, with worked answers and without, as well as advanced topics in later chapters for optional coverage. Incorporates valuable and engaging applications of the content to biological and industrial uses Includes a wealth of useful figures and problems to support reader comprehension and study Provides a high quality chapter on stereochemistry as well as advanced topics such as synthetic polymers and spectroscopy for class customization

Interpretation of the Ultraviolet Spectra of Natural Products

Interpretation of the Ultraviolet Spectra of Natural Products Book
Author : A. I. Scott
Publisher : Elsevier
Release : 2013-10-22
ISBN : 1483137201
Language : En, Es, Fr & De

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Book Description :

Interpretation of the Ultraviolet Spectra of Natural Products focuses on the ultraviolet spectrum of chromophores. The book first discusses single chromophores, including absorption due to electron lone pairs in saturated systems and absorption of olefins, alkynes, carbonyl compounds, and thiocarbonyl compounds. The text also takes a look at conjugated chromosomes, such as polyenes, enynes, and conjugated azomethines. The selection also evaluates C-aromatic compounds. Topics include benzenoid and hydrocarbons; phenols and their ethers; styrenes and stilbenes; aromatic carbonyl compounds; and nitro compounds. The text also discusses O- and S- heteroaromatic compounds and N-heteroaromatic compounds. The book highlights the applications of spectrophotometry to the analysis of natural products. Topics include formation of derivatives having absorbing chromophores; reactions leading to changes in absorption of added reagents; and analyses involving transformation to products suitable for spectrophotometry. The text is a good reference for readers wanting to explore chromophores.

Transition Metal Catalyzed Furans Synthesis

Transition Metal Catalyzed Furans Synthesis Book
Author : Xiao-Feng Wu
Publisher : Elsevier
Release : 2015-09-08
ISBN : 0128040726
Language : En, Es, Fr & De

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Book Description :

Transition Metal Catalyzed Furans Synthesis provides an overview of Furans, describing properties of these heterocycle compounds and covering traditional synthetic procedures for them. This book then explores catalyzed procedures for Furans synthesis in greater detail and depth then is currently available in published Reviews. Finally, this useful short work discusses natural products and bio-active compounds containing Furans, information of particular interest for their applications to medicinal and pharmaceutical chemistry. The short series Transition Metal Catalyzed Heterocycles Synthesis Series, authored by Xiao-Feng Wu, summarizes recent achievements on heterocycles synthesis with transition metal as the catalysts, with each volume dedicated to one heterocycle compound. Brief, focused review of this active research area, Furans synthesis via transition metal catalysis Useful coverage of furans properties and procedures, as well as relevant Furan-containing natural products First volume in short work series, "Transition Metal-Catalyzed Heterocycles Synthesis"

Fluorescent Analogs of Biomolecular Building Blocks

Fluorescent Analogs of Biomolecular Building Blocks Book
Author : Marcus Wilhelmsson
Publisher : John Wiley & Sons
Release : 2016-04-04
ISBN : 1118175867
Language : En, Es, Fr & De

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Book Description :

The first book to serve as both an introduction and state-of-the-art biophysical applications of fluorescent probe, Fluorescent Analogues of Biomolecular Building Blocks focuses on design, synthesis, and implementation of new fluorescent analogues of biomolecular building blocks. Featuring a chapter by Nobelist Roger Tsien, the text focuses on designing fluorescent probes for the four major families of macromolecular building blocks and summarizes the most important and general contributions discussing fluorescent probes that were designed to shed light on biological processes.

Green Synthetic Approaches for Biologically Relevant Heterocycles

Green Synthetic Approaches for Biologically Relevant Heterocycles Book
Author : Goutam Brahmachari
Publisher : Elsevier
Release : 2021-03-20
ISBN : 0323851304
Language : En, Es, Fr & De

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Book Description :

Green Synthetic Approaches for Biologically Relevant Heterocycles, Second Edition, Volume One: Advanced Synthetic Techniques reviews this significant group of organic compounds within the context of sustainable methods and processes, expanding on the first edition with fully updated coverage and a whole range of new chapters. Volume One explores advanced synthetic techniques, with each chapter presenting in-depth coverage of various green protocols for the synthesis of a wide variety of bioactive heterocycles that are classified on the basis of ring-size and/or the presence of heteroatoms. Techniques covered range from high pressure cycloaddition reactions and microwave irradiation to sustainable one-pot domino reactions. This updated edition is an essential resource on sustainable approaches for academic researchers, R&D professionals, and students working across medicinal, organic, natural product and green chemistry. Provides fully updated coverage of the field of greener heterocycle synthesis Includes new chapters on varied multicomponent reactions, alongside both traditional and novel approaches Presents information in an accessible style with an emphasis on sustainability

Organic Chemistry Study Guide

Organic Chemistry Study Guide Book
Author : Robert J. Ouellette,J. David Rawn
Publisher : Elsevier
Release : 2015-04-30
ISBN : 012801864X
Language : En, Es, Fr & De

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Book Description :

Organic Chemistry Study Guide: Key Concepts, Problems, and Solutions features hundreds of problems from the companion book, Organic Chemistry, and includes solutions for every problem. Key concept summaries reinforce critical material from the primary book and enhance mastery of this complex subject. Organic chemistry is a constantly evolving field that has great relevance for all scientists, not just chemists. For chemical engineers, understanding the properties of organic molecules and how reactions occur is critically important to understanding the processes in an industrial plant. For biologists and health professionals, it is essential because nearly all of biochemistry springs from organic chemistry. Additionally, all scientists can benefit from improved critical thinking and problem-solving skills that are developed from the study of organic chemistry. Organic chemistry, like any "skill", is best learned by doing. It is difficult to learn by rote memorization, and true understanding comes only from concentrated reading, and working as many problems as possible. In fact, problem sets are the best way to ensure that concepts are not only well understood, but can also be applied to real-world problems in the work place. Helps readers learn to categorize, analyze, and solve organic chemistry problems at all levels of difficulty Hundreds of fully-worked practice problems, all with solutions Key concept summaries for every chapter reinforces core content from the companion book

Medicinal Foods as Potential Therapies for Type 2 Diabetes and Associated Diseases

Medicinal Foods as Potential Therapies for Type 2 Diabetes and Associated Diseases Book
Author : Solomon Habtemariam
Publisher : Academic Press
Release : 2019-06-08
ISBN : 0081029233
Language : En, Es, Fr & De

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Book Description :

Medicinal Foods as Potential Therapies for Type-2 Diabetes and Associated Diseases: The Chemical and Pharmacological Basis of their Action focuses on active pharmacological principles that modulate diabetes, associated risk factors, complications and the mechanism of action of widely used anti-diabetic herbal plants—rather than just the nutritional composition of certain foods. The book provides up-to-date information on acclaimed antidiabetic super fruits, spices and other food ingredients. Sections cover diabetes and obesity at the global level, the physiological control of carbohydrate and lipid metabolism, the pathophysiology of type-2 diabetes, the chemistry and pharmacology of a variety of spices, and much more. This book will be invaluable for research scientists and students in the medical and pharmaceutical sciences, medicinal chemistry, herbal medicine, drug discovery/development, nutrition science, and for herbal practitioners and those from the nutraceutical and pharm industries. Provides background knowledge on type-2 diabetes and its pathophysiology and therapeutic targets down to the molecular level Explores, in detail, the chemistry or secondary metabolites of the indicated foods that potentially modify diabetes and/or associated diseases Examines the pharmacological findings on medicinal foods, including available clinical trials

Bioprocess Engineering

Bioprocess Engineering Book
Author : Shijie Liu
Publisher : Newnes
Release : 2012-11-21
ISBN : 0444595228
Language : En, Es, Fr & De

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Book Description :

Bioprocess Engineering involves the design and development of equipment and processes for the manufacturing of products such as food, feed, pharmaceuticals, nutraceuticals, chemicals, and polymers and paper from biological materials. It also deals with studying various biotechnological processes. "Bioprocess Kinetics and Systems Engineering" first of its kind contains systematic and comprehensive content on bioprocess kinetics, bioprocess systems, sustainability and reaction engineering. Dr. Shijie Liu reviews the relevant fundamentals of chemical kinetics-including batch and continuous reactors, biochemistry, microbiology, molecular biology, reaction engineering, and bioprocess systems engineering- introducing key principles that enable bioprocess engineers to engage in the analysis, optimization, design and consistent control over biological and chemical transformations. The quantitative treatment of bioprocesses is the central theme of this book, while more advanced techniques and applications are covered with some depth. Many theoretical derivations and simplifications are used to demonstrate how empirical kinetic models are applicable to complicated bioprocess systems. Contains extensive illustrative drawings which make the understanding of the subject easy Contains worked examples of the various process parameters, their significance and their specific practical use Provides the theory of bioprocess kinetics from simple concepts to complex metabolic pathways Incorporates sustainability concepts into the various bioprocesses

Catalytic Amination for N Alkyl Amine Synthesis

Catalytic Amination for N Alkyl Amine Synthesis Book
Author : Feng Shi,Xinjiang Cui
Publisher : Academic Press
Release : 2018-03-14
ISBN : 0128122854
Language : En, Es, Fr & De

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Book Description :

Catalytic Amination for N-Alkyl Amine Synthesis provides a useful survey of this key type of reaction for chemistry researchers in academia and industry. Beginning with an introduction to amination and the development of the field, the book focuses on useful and high potential methods, such as the catalytic amination of alcohol with homogeneous and heterogeneous catalysts, the coupling reaction of olefin and amine, and the reductive amination of carbon dioxide with different reducing agents. The work also discusses two key examples of one-pot synthesis, the oxidative amination of alkane and amine and synthesis of N-alkyl amine with nitrobenzene and nitrile as starting materials. Valuable for chemists, materials scientists, chemical engineers and others, the book offers a unique overview of this growing area and its future possibilities. Describes the catalytic amination of alcohol with homogeneous and heterogeneous catalysts Discusses the one-pot oxidative amination of alkane and amine Explores the application of ammonia as the N-source in amination reaction to avoid primary or secondary amine synthesis

Handbook of Heterocyclic Chemistry

Handbook of Heterocyclic Chemistry Book
Author : Alan R. Katritzky
Publisher : Elsevier
Release : 2017-01-31
ISBN : 1483293424
Language : En, Es, Fr & De

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Book Description :

Provides a one-volume overall picture of the largest of the classical divisions of organic chemistry, suitable for the graduate or advanced undergraduate student, as well as for research workers, both specialists in the field and those engaged in another discipline and requiring knowledge of heterocyclic chemistry. It represents Volume 9 of Comprehensive Heterocyclic Chemistry and utilizes the general chapters which appear in the 8-volume work. The highly systematic coverage given to the subject makes this the most authoritative one-volume account of modern heterocyclic chemistry available.

Functional Dyes

Functional Dyes Book
Author : Sung-Hoon Kim
Publisher : Elsevier
Release : 2006-03-08
ISBN : 0080465625
Language : En, Es, Fr & De

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Book Description :

In the last 10 years organic dyes, traditionally used for coloring textiles and other materials, have become increasingly important in the hi-tech industries of electronics and optoelectronics. They can be used in optical data storage, new solar cells and biomedical sensors. Functional Dyes discusses the synthesis of these new, high-value dyes and pigments as well as their applications and performance. The chapters are arranged so that the reader logically advances from the fundamental concepts to more practical aspects of the technology in which they are used. In providing the reader with current information on functional dye chemistry, as well as important developments within the field, Functional Dyes is a valuable information source for dye and material chemists, researchers and graduates, who want a summary of the key advances in the field over the last 10 years and an authoritative view on future developments. * Provides a broad introduction to the science technology of the functional dye application * Reviews recent advances on synthesis and characteristics of the functional dyes and their applications * Is a valuable information source for dye and material chemists and researchers

Discovery and Development of Neuroprotective Agents from Natural Products

Discovery and Development of Neuroprotective Agents from Natural Products Book
Author : Goutam Brahmachari
Publisher : Elsevier
Release : 2017-05-18
ISBN : 0128097698
Language : En, Es, Fr & De

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Book Description :

Discovery and Development of Neuroprotective Agents from Natural Products draws together global research on medicinal agents from natural sources as starting points for the design of neuroprotective drugs. From the prediction of promising leads and identification of active agents to the extraction of complex molecules, the book explores a range of important topics to support the development of safer, more economical therapeutics for these increasingly prevalent diseases. Beginning with an overview of current developments in the field, the book goes on to explore the identification, extraction and phytochemistry of such neuroprotective agents as antioxidants, biophenols and naturally occurring anti-inflammatory steroid analogues. Specific natural sources of bioactive agents are reviewed, and the development of these agents into therapeutics for a number of specific neurological disorders, including Alzheimer’s disease, Parkinson’s disease and ischemic brain stroke, are discussed. Combining the expertise of specialists from around the world, this in the Natural Products Drug Discovery series aims to support and encourage researchers in the investigation of natural sources as starting points for the development of standardized, safe and effective neuroprotective drugs. Features chapters written by active researchers and leading global experts deeply engaged in the research field of natural product chemistry for drug discovery Includes comprehensive coverage of cutting-edge research advances in the design of drugs from natural products targeted at different kinds of neurodegenerative diseases Offers a practical review of identification, isolation and extraction techniques to support medicinal chemists in the lab

Medicinal Plants of South Asia

Medicinal Plants of South Asia Book
Author : Muhammad Asif Hanif,Haq Nawaz,Muhammad Mumtaz Khan,Hugh J. Byrne
Publisher : Elsevier
Release : 2019-09-14
ISBN : 0081026609
Language : En, Es, Fr & De

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Book Description :

Medicinal Plants of South Asia: Novel Sources for Drug Discovery provides a comprehensive review of medicinal plants of this region, highlighting chemical components of high potential and applying the latest technology to reveal the underlying chemistry and active components of traditionally used medicinal plants. Drawing on the vast experience of its expert editors and authors, the book provides a contemporary guide source on these novel chemical structures, thus making it a useful resource for medicinal chemists, phytochemists, pharmaceutical scientists and everyone involved in the use, sales, discovery and development of drugs from natural sources. Provides comprehensive reviews of 50 medicinal plants and their key properties Examines the background and botany of each source before going on to discuss underlying phytochemistry and chemical compositions Links phytochemical properties with pharmacological activities Supports data with extensive laboratory studies of traditional medicines

Metal and Nonmetal Assisted Synthesis of Six Membered Heterocycles

Metal and Nonmetal Assisted Synthesis of Six Membered Heterocycles Book
Author : Navjeet Kaur
Publisher : Elsevier
Release : 2020-04-25
ISBN : 0128202831
Language : En, Es, Fr & De

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Book Description :

Metal and Nonmetal Assisted Synthesis of Six-Membered Heterocycles provides a useful guide to key approaches being explored in this area. The volume highlights synthetic approaches and catalytic options that facilitate the construction of multiple substituted molecules under mild conditions from easily available starting substrates. Drawing on the experience of its expert author, the book is a useful guide on the key approaches being explored in this area. Following a user-friendly structure based on specific six-membered heterocycle ring groups, this volume highlights synthetic approaches and catalytic options that facilitate the construction of multiple substituted molecules under mild conditions from easily available starting substrates. Highlights new methodologies for the synthesis of different six-membered heterocycles Provides an up-to-date overview of this fast-moving field with an easy-to-use structure Includes novel approaches used in the study and application of catalysts in synthetic organic reactions

Palladium Catalyzed Modification of Nucleosides Nucleotides and Oligonucleotides

Palladium Catalyzed Modification of Nucleosides  Nucleotides and Oligonucleotides Book
Author : Anant R. Kapdi,Debabrata Maiti,Yogesh S. Sanghvi
Publisher : Elsevier
Release : 2018-06-04
ISBN : 012811293X
Language : En, Es, Fr & De

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Book Description :

Palladium-Catalyzed Modification of Nucleosides, Nucleotides and Oligonucleotides describes the procedures and protocols related to the modification of nucleosides, nucleotides and oligonucleotides via Pd-mediated cross-coupling processes. The book highlights the growing area of nucleic acid modification and how Pd-mediated coupling reactions can assist this development. Users will find key synthetic protocols for these reactions in this latest volume in the Latest Trends in Palladium Chemistry series. As most of the research in the field of antiviral agents has centered on the use of modified nucleosides that have exhibited promising activity, this book provides an up-to-date reference for both professionals in industry and other interested parties. Provides synthetic routes for useful nucleoside molecules, information otherwise found only through time-consuming literature searches Covers metal-mediated and metal-catalyzed cross coupling processes of nucleosides and related compounds Includes Suzuki-Miyaura, Stille and Sonogashira reactions, as well as C-H bond functionalization Highlights the growing area of nucleic acid modification and how Pd-mediated coupling reactions can assist

Molecular Modeling of Proteins

Molecular Modeling of Proteins Book
Author : Andreas Kukol
Publisher : Humana Press
Release : 2017-04-30
ISBN : 9781493954919
Language : En, Es, Fr & De

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Book Description :

Molecular Modeling of Proteins, Second Edition provides a theoretical background of various methods available and enables non-specialists to apply methods to their problems by including updated chapters and new material not covered in the first edition. This detailed volume opens by featuring classical and advanced simulation methods as well as methods to set-up complex systems such as lipid membranes and membrane proteins and continues with chapters devoted to the simulation and analysis of conformational changes of proteins, computational methods for protein structure prediction, usage of experimental data in combination with computational techniques, as well as protein-ligand interactions, which are relevant in the drug design process. Written for the highly successful Methods in Molecular Biology series, chapters include thorough introductions, step-by-step instructions and notes on troubleshooting and avoiding common pitfalls. Update-to-date and authoritative, Molecular Modeling of Proteins, Second Edition aims to aid researchers in the physical, chemical and biosciences interested in utilizing this powerful technology.