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Iron Oxide Nanoparticles For Biomedical Applications

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Iron Oxide Nanoparticles for Biomedical Applications

Iron Oxide Nanoparticles for Biomedical Applications Book
Author : Sophie Laurent,Morteza Mahmoudi
Publisher : Elsevier
Release : 2017-10-20
ISBN : 0081012756
Language : En, Es, Fr & De

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Book Description :

Iron Oxide Nanoparticles for Biomedical Applications: Synthesis, Functionalization and Application begins with several chapters covering the synthesis, stabilization, physico-chemical characterization and functionalization of iron oxide nanoparticles. The second part of the book outlines the various biomedical imaging applications that currently take advantage of the magnetic properties of iron oxide nanoparticles. Brief attention is given to potential iron oxide based therapies, while the final chapter covers nanocytotoxicity, which is a key concern wherever exposure to nanomaterials might occur. This comprehensive book is an essential reference for all those academics and professionals who require thorough knowledge of recent and future developments in the role of iron oxide nanoparticles in biomedicine. Unlocks the potential of iron oxide nanoparticles to transform diagnostic imaging techniques Contains full coverage of new developments and recent research, making this essential reading for researchers and engineers alike Explains the synthesis, processing and characterization of iron oxide nanoparticles with a view to their use in biomedicine

Superparamagnetic Iron Oxide Nanoparticles for Biomedical Applications

Superparamagnetic Iron Oxide Nanoparticles for Biomedical Applications Book
Author : Do-Kyung Kim,Kungl. Tekniska högskolan,Tekniska högskolan i Stockholm. Institutionen för materialvetenskap
Publisher : Unknown
Release : 2001
ISBN : 9789172831261
Language : En, Es, Fr & De

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Book Description :

Download Superparamagnetic Iron Oxide Nanoparticles for Biomedical Applications book written by Do-Kyung Kim,Kungl. Tekniska högskolan,Tekniska högskolan i Stockholm. Institutionen för materialvetenskap, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Iron Oxide Nanoparticles for Biomedical Applications

Iron Oxide Nanoparticles for Biomedical Applications Book
Author : Shirin Pourmiri
Publisher : Unknown
Release : 2020
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The research in this dissertation has been focused on the synthesis of iron oxide nanoparticles and their nanoclusters, the characterization of their magnetic and structural properties and their hyperthermia response for biomedical applications. The aim was to enhance the heating efficiency of nanoparticles using different methodologies such as changing the particle size and shape anisotropy, as well as increasing the dipolar interactions by nanoparticle clustering.

Biotransport of Iron Oxide Magnetic Nanoparticles for Biomedical Applications

Biotransport of Iron Oxide Magnetic Nanoparticles for Biomedical Applications Book
Author : Venkatasubramaniam S. Kalambur
Publisher : Unknown
Release : 2007
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Biotransport of Iron Oxide Magnetic Nanoparticles for Biomedical Applications book written by Venkatasubramaniam S. Kalambur, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Multifunctional Iron Oxide Nanoparticles for Biomedical Applications

Multifunctional Iron Oxide Nanoparticles for Biomedical Applications Book
Author : Yaolin Xu
Publisher : Unknown
Release : 2014
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This dissertation focuses on the preparation of multifunctional nanoparticles through the integration of iron oxide nanoparticles with other desired moieties. Iron oxide nanoparticles have been widely explored in localized therapy, targeted delivery, and magnetic resonance imaging. However, inaccessible MRI instruments for most research labs and lack of targeting ligands limits the further exploration of iron oxide nanoparticles in routine tumor diagnosis and efficient therapy. Therefore, the preparation of dual-imaging or targeted nanoparticles is highly desirable. In our studies, fluorescent gold nanoclusters or anti & ndashdisialoganglioside & ndashGD2 monoclonal antibodies are integrated onto iron oxide nanoparticle surfaces. The gold nanoclusters provide additional fluorescent imaging capability, which can be easily accessed in common research labs. The conjugation of cancer cell & ndashtargeting antibodies allows for specific localization of nanoparticles. Indeed, these are the two central themes of this dissertation. To prepare multifunctional nanoparticles, high & ndashquality iron oxide nanoparticles were first synthesized in organic solvents following a modified & ldquoheat & ndashup & rdquo method. During synthesis, a modification was made by introducing a co & ndashsurfactant (trioctylphosphine oxide & ndashTOPO). TOPO facilitated the subsequent ligand exchange process because it weakly bound to nanoparticle surfaces and prevented the formation of densely & ndashpacked surfactant coatings. As a result, hydrophilic molecules (such as polyacrylic acid, polyethylenimine, glutathione and dopamine) were capable of replacing the original ligands, yielding water & ndashsoluble iron oxide nanoparticles. In addition to water solubility, dopamine coatings offered nanoparticles additional conjugation capability upon surface oxidization. These surface & ndashoxidized nanoparticles can directly conjugate with amine and/or thiol group & ndashcontained molecules through Michael addition and/or Schiff base formation. Using this conjugation strategy, dual & ndashimaging nanoparticles were prepared by integrating dopamine & ndashcoated nanoparticles with protein (such as bovine serum albumin, trypsin and lysozyme) & ndash encapsulated fluorescent gold nanoclusters. All integrated nanoparticles maintained their functionalities and structural integrity in biological environments. Furthermore, effects of protein characteristics on the photo & ndashchemical properties of gold nanoclusters and integrated nanoparticles were systematically examined. Similarly, cancer cell & ndashtargeting molecules (e.g. anti & ndashGD2 monoclonal antibodies) were conjugated onto dopamine & ndashcoated nanoparticles. After conjugation, antibodies retained their high targeting specificity, suggested by our cellular targeting studies. More promisingly, conjugated nanoparticles were capable of transporting into cytosols, which opens up new possibilities in cancer & ndashcuring drug loading and targeted therapy. Besides these already & ndashpublished works, we have studied the biological responses of human monocytes to different surface & ndashcharged iron oxide nanoparticles (manuscript in preparation). For dual & ndashimaging nanoparticles, their stability and bio & ndashimaging potential will be evaluated in phorbol myristate acetate (PMA) & ndashtreated monocytes using differential interference contrast (DIC) and confocal microscopy.

Superparamagnetic Iron Oxide Nanoparticles

Superparamagnetic Iron Oxide Nanoparticles Book
Author : Morteza Mahmoudi
Publisher : Unknown
Release : 2011
ISBN : 9781617286315
Language : En, Es, Fr & De

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Book Description :

Download Superparamagnetic Iron Oxide Nanoparticles book written by Morteza Mahmoudi, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

M ssbauer Spectroscopy of Iron Oxide Nanoparticles

M  ssbauer Spectroscopy of Iron Oxide Nanoparticles Book
Author : Hien-Yoong Hah
Publisher : Unknown
Release : 2018
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Nanoparticles of Fe3O4 (magnetite) and gamma-Fe2O3 (maghemite) have been studied by Mössbauer spectroscopy. These nanoparticles have applications as contrast agents for Magnetic Resonance Imaging. At room temperature, they are superparamagnetic and the magnetic hyperfine fields were averaged to zero. The spectra of Fe3O4 were composed of two lines corresponding to two crystal sites, identified from their isomer shifts as Fe3+ on the tetrahedral A site and Fe2·5+ (mixed Fe2+ and Fe3+) on the octahedral B site. The relative intensity of the two lines shows that the samples are almost stoichiometric with the formula Fe3−x̳O4, where x is less than 0.04 at room temperature. The x that was obtained was compared to those obtained in a magnetic field and at room temperature. The lines are broad and the measurements as a function of temperature were analyzed using Néel's theory of superparamagnetism to yield values of the relaxation times. The same nanoparticles that have oxidized into gamma-Fe2O3 have been studied for comparison.

Syntheses and Surface Modifications of Gold and Iron Oxide Nanoparticles for Organic and Biomedical Applications

Syntheses and Surface Modifications of Gold and Iron Oxide Nanoparticles for Organic and Biomedical Applications Book
Author : Jinda Fan
Publisher : Unknown
Release : 2006
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Syntheses and Surface Modifications of Gold and Iron Oxide Nanoparticles for Organic and Biomedical Applications book written by Jinda Fan, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Synthesis and Development of Hydrophilic Iron Oxide Nanoparticles for Biomedical Applications

Synthesis and Development of Hydrophilic Iron Oxide Nanoparticles for Biomedical Applications Book
Author : He Wei (Ph.D.),Massachusetts Institute of Technology. Department of Chemistry
Publisher : Unknown
Release : 2014
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Uniformly sized superparamagnetic iron oxide nanoparticles (SPIONs) with inorganic diameters of 3-35 nm were synthesized. New surface ligand coatings were designed and synthesized, and the resulting hydrophilic SPIONs in biological buffers were found to be compact, stable, highly magnetic, and biocompatible. Furthermore, the hydrophilic SPIONs were stable in vitro in serums and cells as well as in vivo in mice. Functionalized SPIONs demonstrated the ability of specific labeling. Finally, the hydrophilic SPIONs have potential as a non-toxic alternative to Gadolinium based contrast agents for T1-weighted magnetic resonance imaging (MRI) and they have shown potential in multicolor MRI as well as magnetic particle imaging.

Superparamagnetic Iron Oxide Nanoparticles

Superparamagnetic Iron Oxide Nanoparticles Book
Author : Morteza Mahmoudi,Pieter Stroeve,Abbas S. Milani,Ali S. Arbab
Publisher : Nova Science Pub Incorporated
Release : 2011
ISBN : 9781616689643
Language : En, Es, Fr & De

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Book Description :

In recent years, the fabrication of nanoparticles and exploration of their properties have attracted the attention of physicists, chemists, biologists and engineers. Interest in nanoparticles arise from the fact that the mechanical, chemical, electrical, optical, magnetic, electro-optical and magneto-optical properties of these particles are different from their bulk properties and depend on the particle size. There are numerous areas where nanoparticulate systems are of scientific and technological interest. This book reviews research on the various components of superparamagnetic iron oxide nanoparticles.

Application and Biomedical Effects of Iron Oxide Nanoparticles

Application and Biomedical Effects of Iron Oxide Nanoparticles Book
Author : 蕭仲凱
Publisher : Unknown
Release : 2008
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Application and Biomedical Effects of Iron Oxide Nanoparticles book written by 蕭仲凱, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Synthesis Strategies of Single core and Multi core Iron Oxide Magnetic Nanoparticles for Biomedical Applications

Synthesis Strategies of Single core and Multi core Iron Oxide Magnetic Nanoparticles for Biomedical Applications Book
Author : Helena Gavilán Rubio
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

In this thesis, iron oxides nanoparticles has been the case of study (more specifically magnetite and maghemite iron oxide phases), since this nanomaterial presents some interesting features and advantages that arise from its chemical composition and atomic structure. First, the most important feature is that magnetic nanoparticles obey Coulomb’s law,[1] and this means that they can be manipulated by an external magnetic field gradient. Moreover, magnetic nanoparticles can be made to resonantly respond to a time-varying magnetic field, with advantageous results related to the transfer of energy from the exciting field to the nanoparticle.[2] Finally, magnetic nanoparticles affect the relaxivity of surrounding protons. Based on these features, magnetic nanoparticles are emerging functional materials in material science industry and biomedicine...

Mineralogy

Mineralogy Book
Author : Ali Al-Juboury
Publisher : BoD – Books on Demand
Release : 2020-05-27
ISBN : 1789858259
Language : En, Es, Fr & De

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Book Description :

Mineralogy - Significance and Applications includes new contributions to the field of mineralogy in terms of mineral chemistry and petrogenesis using updated facilities from regions in Asia and Europe to interpret petrologic significance. It discusses the industrial uses of some minerals as raw materials and in electrical firms and gemology. The book also introduces several works on synthesis of some compounds and applications of mineralogy in biomedicine, including iron oxide nanoparticles and nannocomposites, and their biomedical applications as diagnostic and drug delivery tools for treatment of cancer and many other diseases.

Nanomedicine

Nanomedicine Book
Author : Marc J. Williams,Serena A. Corr
Publisher : Elsevier Inc. Chapters
Release : 2013-09-19
ISBN : 0128055405
Language : En, Es, Fr & De

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Book Description :

The past two decades have seen a surge in the development and application of nanoparticles for biomedical uses, with a focused effort on engineering particles for ‘theranostic’ applications where diagnosis and disease treatment are possible using a single platform. Magnetic nanoparticles, in particular, are ideal candidates for this kind of multimodal action, given their potential use spans magnetic resonance (MR) imaging, magnetic hyperthermia and targeted drug delivery. This is due to unique properties their size bestows on them. Here, we examine these properties of magnetic nanoparticles and how they govern the particle efficacy for a desired application. Given the intimate link between synthetic approach chosen and subsequent properties, we will also discuss typical and emerging routes to magnetic nanoparticle preparation. We will, in detail, describe the uses of magnetic nanoparticles as diagnostic and therapeutic tools, with particular emphasis on their use as MR contrast agents and the most recent developments in targeted drug delivery. Finally, we will present an outlook for the future of these important materials.

Biomedical Applications of Magnetic Particles

Biomedical Applications of Magnetic Particles Book
Author : Jeffrey N. Anker,O. Thompson Mefford
Publisher : CRC Press
Release : 2020-12-17
ISBN : 1439839697
Language : En, Es, Fr & De

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Book Description :

Biomedical Applications of Magnetic Particles discusses fundamental magnetic nanoparticle physics and chemistry and explores important biomedical applications and future challenges. The first section presents the fundamentals of the field by explaining the theory of magnetism, describing techniques to synthesize magnetic particles, detailing methods to characterize magnetic particles, and quantitatively describing the applied magnetic forces, torques, and the resultant particle motions. The second section describes the wide range of biomedical applications, including chemical sensors, cellular actuators, drug delivery, magnetic hyperthermia, magnetic resonance imaging contrast enhancement, and toxicity. Additional key features include: Covers both introduction to physics and characterization of magnetic nanoparticles and the state of the art in biomedical applications Authoritative reference for scientists and engineers for all new or old to the field Describes how the size of magnetic nanoparticles affects their magnetic properties, colloidal properties, and biological properties. Written by a team of internationally respected experts, this book provides an up-to-date authoritative reference for scientists and engineers.

Clinical Applications of Magnetic Nanoparticles

Clinical Applications of Magnetic Nanoparticles Book
Author : Nguyen TK Thanh
Publisher : CRC Press
Release : 2018-02-06
ISBN : 1351685422
Language : En, Es, Fr & De

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Book Description :

Offering the latest information in magnetic nanoparticle (MNP) research, this book builds upon the success of the first volume and provides an updated and comprehensive review, from synthesis, characterization, and biofunctionalization to clinical applications of MNPs, including the diagnosis and treatment of cancers. The book captures some of emerging research area which was not available in the first volume. Good Manufacturing Practices and Commercialization of MNPs are also included. This volume, also written by some of the most qualified experts in the field, incorporates new developments in the literature, and continues to bridge the gaps between the different areas in this field.

Modified Seed Growth of Iron Oxide Nanoparticles in Benzyl Alcohol

Modified Seed Growth of Iron Oxide Nanoparticles in Benzyl Alcohol Book
Author : Stanley Eugene Gilliland (III)
Publisher : Unknown
Release : 2014
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Iron oxide nanoparticles have received sustained interest for biomedical applications as synthetic approaches are continually developed for precise control of nanoparticle properties. This thesis presents an investigation of parameters in the benzyl alcohol synthesis of iron oxide nanoparticles. A modified seed growth method was designed for obtaining optimal nanoparticle properties for magnetic fluid hyperthermia. With a one or two addition process, iron oxide nanoparticles were produced with crystallite sizes ranging from 5-20 nm using only benzyl alcohol and iron precursor. The effects of reaction environment, temperature, concentration, and modified seed growth parameters were investigated to obtain precise control over properties affecting radiofrequency heat generation. The reaction A2-24(205)_B2-24(205) produced monodispersed (PDI=0.265) nanoparticles with a crystallite size of 19.5±1.06 nm and the highest radiofrequency heating rate of 4.48 (°C/min)/mg (SAR=1,175.56 W/g, ILP=3.1127 nHm2/kg) for the reactions investigated. The benzyl alcohol modified seed growth method offers great potential for synthesizing iron oxide nanoparticles for radiofrequency hyperthermia.

Magnetic Nanoparticles

Magnetic Nanoparticles Book
Author : Evgeny Katz
Publisher : MDPI
Release : 2020-03-05
ISBN : 3039282689
Language : En, Es, Fr & De

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Book Description :

The present book covers all research areas related to magnetic nanoparticles, magnetic nanorods, and other magnetic nanospecies, their preparation, characterization, and various applications, specifically emphasizing biomedical applications. The chapters written by the leading experts cover different subareas of the science and technology related to various magnetic nanospecies—providing broad coverage of this multifaceted area and its applications. The different topics addressed in this book will be of great interest to the interdisciplinary community active in the area of nanoscience and nanotechnology. It is hoped that this collection and its various chapters will be important and beneficial for researchers and students working in various areas related to bionanotechnology, materials science, biosensor applications, medicine, and many others. Furthermore, this book is aimed at attracting young scientists and introducing them to this field, in addition to providing newcomers with an enormous collection of literature references.