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Ipscs For Modeling Infectious Diseases

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Pluripotent Stem Cells

Pluripotent Stem Cells Book
Author : Minoru Tomizawa
Publisher : BoD – Books on Demand
Release : 2016-07-20
ISBN : 9535124714
Language : En, Es, Fr & De

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Book Description :

Pluripotent stem cells have distinct characteristics: self-renewal and the potential to differentiate into various somatic cells. In recent years, substantial advances have been made from basic science to clinical applications. The vast amount knowledge available makes obtaining concise yet sufficient information difficult, hence the purpose of this book. In this book, embryonic stem cells, induced pluripotent stem cells, and mesenchymal stem cells are discussed. The book is divided into five sections: pluripotency, culture methods, toxicology, disease models, and regenerative medicine. The topics covered range from new concepts to current technologies. Readers are expected to gain useful information from expert contributors.

Recent Advances in iPSC Disease Modeling Volume 1

Recent Advances in iPSC Disease Modeling  Volume 1 Book
Author : ALEXANDER BIRBRAIR
Publisher : Academic Press
Release : 2020-07-16
ISBN : 0128232692
Language : En, Es, Fr & De

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Book Description :

Recent Advances in iPSC Disease Modeling, Volume 1 addresses how induced pluripotent stem cells can be used to model various diseases. Somatic cells are reprogrammed into induced pluripotent stem cells by the expression of specific transcription factors. These cells are transforming biomedical research in the last 15 years. This volume teaches readers about current advances in the field. This book describes the use of induced pluripotent stem cells to model several diseases in vitro, enabling us to study the cellular and molecular mechanisms involved in different pathologies. Further insights into these mechanisms will have important implications for our understanding of disease appearance, development, and progression. In recent years, remarkable progress has been made in the obtention of induced pluripotent stem cells and their differentiation into several cell types, tissues, and organs using state-of-art techniques. These advantages facilitated identification of key targets and definition of the molecular basis of several disorders. The volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation; and is contributed by world-renowned authors in the field. Provides overview of the fast-moving field of induced pluripotent stem cell technology, regenerative medicine, and therapeutics Covers the following diseases: severe congenital neutropenia, sickle cell and Diamond-Blackfan anemias, muscular dystrophies, Bernard-Soulier syndrome, familial hypercholesterolemia type II A, Werner syndrome, lysosomal storage diseases, and more Contains description of cutting-edge research on the development of disease-specific human pluripotent stem cells. These cells allow us to study cellular and molecular processes involved in several human diseases

iPSCs for Studying Infectious Diseases

iPSCs for Studying Infectious Diseases Book
Author : Alexander Birbrair
Publisher : Academic Press
Release : 2021-05-29
ISBN : 0128241896
Language : En, Es, Fr & De

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Book Description :

The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. iPSCs for Studying Infectious Diseases, Volume 8 addresses how important induced pluripotent stems cells are and how can they can help treat certain infectious diseases. Somatic cells can be reprogrammed into induced pluripotent stem cells by the expression of specific transcription factors. These cells have been transforming biomedical research over the last 15 years. This volume will address the advances in research of how induced pluripotent stem cells are being used for treatment of different infectious diseases, such as corona virus, coxsackievirus, salmonella infection, influenza virus and much more. The volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation; and is contributed by world-renowned authors in the field. Provides overview of the fast-moving field of stem cell biology and function, regenerative medicine, and therapeutics Covers infections by several pathogens, such as coronavirus, coxsackievirus, influenza virus, herpes simplex virus 1, T. gondii, T. cruzi, S. agalactiae, N. meningitidis, Salmonella, and more Is contributed by world-renowned experts in the field

Phenotyping of Human iPSC derived Neurons

Phenotyping of Human iPSC derived Neurons Book
Author : Elizabeth D. Buttermore
Publisher : Academic Press
Release : 2022-09-30
ISBN : 0128222786
Language : En, Es, Fr & De

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Book Description :

Phenotyping of Human iPSC-derived Neurons: Patient-Driven Research examines the steps in a preclinical pipeline that utilizes iPSC-derived neuronal technology to better understand neurological disorders and identify novel therapeutics, also providing considerations and best practices. By presenting example projects that identify phenotypes and mechanisms relevant to autism spectrum disorder and epilepsy, this book allows readers to understand what considerations are important to assess at the start of project design. Sections address reproducibility issues and advances in technology at each stage of the pipeline and provide suggestions for improvement. From patient sample collection and proper controls to neuronal differentiation, phenotyping, screening, and considerations for moving to the clinic, these detailed descriptions of each stage of the pipeline will help everyone, regardless of stage in the pipeline. In recent years, drug discovery in the neurosciences has struggled to identify novel therapeutics for patients with varying indications, including epilepsy, chronic pain, and psychosis. Current treatment options for such patients are decades old and offer little relief with many side effects. One explanation for this lull in novel therapeutics is a lack of novel target identification for neurological disorders (and target identification requires exemplar preclinical data). To improve on the preclinical work that often relies on rodent modeling, the field has begun utilizing patient-derived induced pluripotent stem cells (iPSCs) to differentiate neurons in vitro for preclinical characterization of neurological disease and target identification. Discusses techniques and new technology for iPSC culturing and neuronal differentiation to establish best practices in the lab Outlines considerations for phenotypic assay development Provides information about the successes, failures, and implications of phenotyping and screening with iPSC-derived neurons Describes how human iPSC-derived neurons are being used for preclinical discovery research as well as the development of therapeutics utilizing hiPSC-derived neurons

Lung Stem Cells in Development Health and Disease

Lung Stem Cells in Development  Health and Disease Book
Author : Nikolic, Marko Z.,Hogan, Brigid L.M.
Publisher : European Respiratory Society
Release : 2021-04-01
ISBN : 1849841349
Language : En, Es, Fr & De

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Book Description :

Most organs in the adult human body are able to maintain themselves and undergo repair after injury; these processes are largely dependent on stem cells. In this Monograph, the Guest Editors bring together leading authors in the field to provide information about the different classes of stem cells present both in the developing and adult lung: where they are found, how they function in homeostasis and pathologic conditions, the mechanisms that regulate their behaviour, and how they may be harnessed for therapeutic purposes. The book focuses on stem cells in the mouse and human lung but also includes the ferret as an increasingly important new model organism. Chapters also discuss how lung tissue, including endogenous stem cells, can be generated in vitro from pluripotent stem cell lines. This state-of-the-art collection comprehensively covers one of the most exciting areas of respiratory science

Frontiers in Pluripotent Stem Cells Research and Therapeutic Potentials Bench to Bedside

Frontiers in Pluripotent Stem Cells Research and Therapeutic Potentials Bench to Bedside Book
Author : Kuldip S. Sidhu
Publisher : Bentham Science Publishers
Release : 2012
ISBN : 1608052893
Language : En, Es, Fr & De

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Book Description :

"Pluripotent stem cells have garnered tremendous interest in recent years, which is primarily driven by the hope of finding a cure for several debilitating human diseases. Cell transplantation (regeneratve medicine) offers considerable therapeutic potentia"

Novel Concepts in iPSC Disease Modeling

Novel Concepts in iPSC Disease Modeling Book
Author : Alexander Birbrair
Publisher : Academic Press
Release : 2022-01-25
ISBN : 0128238836
Language : En, Es, Fr & De

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Book Description :

The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. iPSCs - Novel Concepts, Volume 15 addresses how important induced pluripotent stems cells are and how can they can help treat certain diseases. Somatic cells can be reprogrammed into induced pluripotent stem cells by the expression of specific transcription factors. These cells have been transforming biomedical research over the last 15 years. This volume will address the advances in research of how induced pluripotent stem cells are being used for treatment of different disorders, such as liver disease, type-1 diabetes, Parkinson’s disease, macular degeneration of the retina and much more. The volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation; and is contributed by world-renowned authors in the field. Provides overview of the fast-moving field of stem cell biology and function, regenerative medicine and therapeutics Covers spinal cord injuries, type-1 diabetes, liver disease, Parkinson’s disease, graft vs. host disease, and much more Contributed by world-renown experts in the field

Introduction to Biotech Entrepreneurship From Idea to Business

Introduction to Biotech Entrepreneurship  From Idea to Business Book
Author : Florentina Matei,Daniela Zirra
Publisher : Springer
Release : 2019-08-16
ISBN : 3030221415
Language : En, Es, Fr & De

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Book Description :

Primarily intended for biotechnology graduates, this handbook provides an overview of the requirements, opportunities and drawbacks of Biotech Entrepreneurship, while also presenting valuable training materials tailored to the industrial and market reality in the European Biotech Business. Potential investors and business consultants will find essential information on the benefits and potential risks involved in supporting biotech businesses. Further, the book addresses a broad range of Biotechnology fields, e.g. food biotech, industrial biotech, bioinformatics, animal and human health. Readers will learn the essentials of creating innovations, founding a biotech start-up, business management strategies, and European funding sources. In addition, the book discusses topics such as intellectual property management and innovation transfer. The book offers a comparative analysis of different countries’ perspectives and reviews the status quo in Western and Eastern European regions, also in comparison with other leading biotech countries such as the USA and Canada. A long list of potentially profitable biotech start-up ideas and a collection of success stories involving European companies are also included. The book is based on the Erasmus+ Strategic Partnership project “Supporting biotechnology students oriented towards an entrepreneurial path” (www.supbioent.usamv.ro), which involved the collaboration of Life Sciences and Economics departments at higher education institutions throughout Western and Eastern Europe.

Stem Cell Processing

Stem Cell Processing Book
Author : Phuc Van Pham
Publisher : Springer
Release : 2016-10-18
ISBN : 3319400738
Language : En, Es, Fr & De

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Book Description :

This invaluable resource delineates procedures for development and use of stem cells in the laboratory and explores the potential for clinical applications. The text discusses mesenchymal stem cell isolation, isolation of adipose derived stem cells, new trends of induced pluripotent stem cells in disease treatment, cord blood banking, future directions of the discussed therapies and much more. The chapters are contributed by preeminent scientists in the field and present a comprehensive picture of stem cell processes, from development in the laboratory to effects and side-effects of clinical application. Stem Cell Processing and the other books in the Stem Cells in Clinical Applications series, edited by Dr. Phuc Van Pham, is essential reading for scientists, researchers, advanced students and clinicians working in stem cells, regenerative medicine or tissue engineering.

iPS Cells for Modelling and Treatment of Human Diseases

iPS Cells for Modelling and Treatment of Human Diseases Book
Author : Michael J. Edel
Publisher : MDPI
Release : 2018-10-02
ISBN : 3038421227
Language : En, Es, Fr & De

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Book Description :

This book is a printed edition of the Special Issue "iPS Cells for Modelling and Treatment of Human Diseases" that was published in JCM

Tumor Organoids

Tumor Organoids Book
Author : Shay Soker,Aleksander Skardal
Publisher : Humana Press
Release : 2017-10-20
ISBN : 3319605119
Language : En, Es, Fr & De

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Book Description :

Cancer cell biology research in general, and anti-cancer drug development specifically, still relies on standard cell culture techniques that place the cells in an unnatural environment. As a consequence, growing tumor cells in plastic dishes places a selective pressure that substantially alters their original molecular and phenotypic properties.The emerging field of regenerative medicine has developed bioengineered tissue platforms that can better mimic the structure and cellular heterogeneity of in vivo tissue, and are suitable for tumor bioengineering research. Microengineering technologies have resulted in advanced methods for creating and culturing 3-D human tissue. By encapsulating the respective cell type or combining several cell types to form tissues, these model organs can be viable for longer periods of time and are cultured to develop functional properties similar to native tissues. This approach recapitulates the dynamic role of cell–cell, cell–ECM, and mechanical interactions inside the tumor. Further incorporation of cells representative of the tumor stroma, such as endothelial cells (EC) and tumor fibroblasts, can mimic the in vivo tumor microenvironment. Collectively, bioengineered tumors create an important resource for the in vitro study of tumor growth in 3D including tumor biomechanics and the effects of anti-cancer drugs on 3D tumor tissue. These technologies have the potential to overcome current limitations to genetic and histological tumor classification and development of personalized therapies.

Human Embryonic Stem Cells

Human Embryonic Stem Cells Book
Author : Arlene Chiu,Mahendra S. Rao
Publisher : Springer Science & Business Media
Release : 2003-08-01
ISBN : 1592594239
Language : En, Es, Fr & De

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Book Description :

A discussion of all the key issues in the use of human pluripotent stem cells for treating degenerative diseases or for replacing tissues lost from trauma. On the practical side, the topics range from the problems of deriving human embryonic stem cells and driving their differentiation along specific lineages, regulating their development into mature cells, and bringing stem cell therapy to clinical trials. Regulatory issues are addressed in discussions of the ethical debate surrounding the derivation of human embryonic stem cells and the current policies governing their use in the United States and abroad, including the rules and conditions regulating federal funding and questions of intellectual property.

iPSCs State of the Science

iPSCs   State of the Science Book
Author : Alexander Birbrair
Publisher : Academic Press
Release : 2022-01-09
ISBN : 0323856454
Language : En, Es, Fr & De

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Book Description :

iPSCs - State of the Science, Volume Sixteen, the latest release in the Advances in Stem Cell Biology series, is an expansive collection of information and new discoveries in the field. This volume addresses the importance of induced pluripotent stems cells and how can they be derived from different sources. It addresses advances in research in induced pluripotent stem cells from alternate sources, such as spermatogonial stem cells, ovarian tissue, cancer cells, and many other sources. It is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation, and is contributed by world-renowned authors. Provides an overview of the fast-moving field of stem cell biology and function, regenerative medicine and therapeutics Covers iPSCs derived from amniotic fluid, oral tissue derived iPSCs, muse cells, postmortem tissue, and much more Contributed by world-renowned experts in the field

Current Progress in iPSC derived Cell Types

Current Progress in iPSC derived Cell Types Book
Author : Alexander Birbrair
Publisher : Academic Press
Release : 2021-06-02
ISBN : 0128238852
Language : En, Es, Fr & De

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Book Description :

The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. Current Progress in iPSC-derived Cell Types, Volume 10 addresses how induced pluripotent stem cells can be differentiated into different cell types. Somatic cells can be reprogrammed into induced pluripotent stem cells by the expression of specific transcription factors. These cells have been transforming biomedical research over the last 15 years. This volume will address the advances in research of how research of induced pluripotent stem cells can be reprogrammed to develop new treatment technologies in regenerative medicine. The volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation; and is contributed by world-renowned authors in the field. Provides overview of the fast-moving field of stem cell biology and function, regenerative medicine and therapeutics Covers iPSCs derived cardiomyocytes, skeletal muscles, brown adipocytes, airway epithelial cells, and much more Contributed by world-renown experts in the field

Stem cells in Tissue Homeostasis and Disease

Stem cells in Tissue Homeostasis and Disease Book
Author : Yan-Ru Lou,Wencheng Zhang,Jianjun Zhou,Zhiying He
Publisher : Frontiers Media SA
Release : 2022-03-29
ISBN : 2889748014
Language : En, Es, Fr & De

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Book Description :

Download Stem cells in Tissue Homeostasis and Disease book written by Yan-Ru Lou,Wencheng Zhang,Jianjun Zhou,Zhiying He, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Translational Regenerative Medicine

Translational Regenerative Medicine Book
Author : Anthony Atala,Julie Allickson
Publisher : Academic Press
Release : 2014-12-01
ISBN : 0124104576
Language : En, Es, Fr & De

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Book Description :

Translational Regenerative Medicine is a reference book that outlines the life cycle for effective implementation of discoveries in the dynamic field of regenerative medicine. By addressing science, technology, development, regulatory, manufacturing, intellectual property, investment, financial, and clinical aspects of the field, this work takes a holistic look at the translation of science and disseminates knowledge for practical use of regenerative medicine tools, therapeutics, and diagnostics. Incorporating contributions from leaders in the fields of translational science across academia, industry, and government, this book establishes a more fluid transition for rapid translation of research to enhance human health and well-being. Provides formulaic coverage of the landscape, process development, manufacturing, challenges, evaluation, and regulatory aspects of the most promising regenerative medicine clinical applications Covers clinical aspects of regenerative medicine related to skin, cartilage, tendons, ligaments, joints, bone, fat, muscle, vascular system, hematopoietic /immune system, peripheral nerve, central nervous system, endocrine system, ophthalmic system, auditory system, oral system, respiratory system, cardiac system, renal system, hepatic system, gastrointestinal system, genitourinary system Identifies effective, proven tools and metrics to identify and pursue clinical and commercial regenerative medicine

Current Progress in iPSC Disease Modeling

Current Progress in iPSC Disease Modeling Book
Author : Alexander Birbrair
Publisher : Academic Press
Release : 2021-11-26
ISBN : 0323856438
Language : En, Es, Fr & De

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Book Description :

Current Progress in iPSC Disease Modeling, Volume Fourteen in the Advances in Stem Cell Biology series, is a timely and expansive collection of information and new discoveries in the field. This new volume addresses advances in research on how induced pluripotent stem cells are used for the creation of new tissues and organs. The creation of iPSC technology allowed the development of disease-specific human pluripotent stem cells. These cells allow researchers to study questions once impossible for some human diseases. This volume addresses iPSCs for vascular tissue engineering, bioprinting, derived lung organoids for pulmonary disorders, skeletal muscle engineering, human kidney organoids, and more. It is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation, and is contributed by world-renowned authors in the field. Provides an overview of the fast-moving field of stem cell biology and function, regenerative medicine and therapeutics Covers advances in research on how induced pluripotent stem cells are used to create new tissues/organs Contributed by world-renowned experts in the field

Group B Coxsackieviruses

Group B Coxsackieviruses Book
Author : Steven Tracy,M. Steven Oberste,Kristen M. Drescher
Publisher : Springer Science & Business Media
Release : 2008-02-13
ISBN : 3540755462
Language : En, Es, Fr & De

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Book Description :

At last – a volume that virologists have been waiting for: a fully updated new edition of a major study in a key subject area. The first edition of this work, published in 1997, described the molecular biology of coxsackie B viruses, as well as clinical, epidemiological, and immunological aspects of group B coxsackievirus disease. This brand new edition covers all the research accomplishments of the last ten years in this vital area of medicine, including immunopathology.

iPSC Derived Progenitors

iPSC Derived Progenitors Book
Author : Alexander Birbrair
Publisher : Academic Press
Release : 2021-11-10
ISBN : 0323900739
Language : En, Es, Fr & De

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Book Description :

iPSC Derived Progenitors, Volume Thirteen in the Advances in Stem Cell Biology series is a timely collection of information and new discoveries in the field of stem cell biology. The book addresses the importance of induced pluripotent stems cells and how can they be differentiated into different progenitors. Progenitors cells are often the first-step to making more differentiating cell types. This volume addresses iPSCs derived from bone, dental pulp, craniofacial, neural stem cells, otic, cardiac, and much more. The volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine, organ transplantation, and is contributed by world-renowned authors. Provides an overview of the fast-moving field of stem cell biology and function, regenerative medicine and therapeutics Covers how iPSCs can be differentiated into different progenitors Contributed by world renowned experts in the field

Alzheimer s and Parkinson s Diseases

Alzheimer   s and Parkinson   s Diseases Book
Author : Israel Hanin,Mitsuo Yoshida,Abraham Fisher
Publisher : Springer Science & Business Media
Release : 2013-06-29
ISBN : 1475791453
Language : En, Es, Fr & De

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Book Description :

This book represents the third in a series of International Conferences related to Alzheimer's (AD) and Parkinson's (PD) diseases. The first one took place in Eilat, Israel, in 1985; and the second one in Kyoto, Japan, in 1989. This book contains the full text of oral and poster presentations from the Third International Conference on Alzheimer's and Parkinson's Diseases: Recent Developments, held in Chicago, Illinois, U.S.A. on November 1-6, 1993. The Chicago Conference was attended by 270 participants. The Scientific Program was divided into nine oral sessions, a keynote presentation, and a poster session. The conference culminated in a Round Table Discussion involving all of the participants in the conference. The four and one-half day meeting served as an excellent medium for surveying the current status of clinical and preclinical developments in AD and PD. There were 59 oral presentations and 93 posters. This book incorporates a majority of both.