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Introductory Review On Sirtuins In Biology Aging And Disease

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Introductory Review on Sirtuins in Biology Aging and Disease

Introductory Review on Sirtuins in Biology  Aging  and Disease Book
Author : Leonard Guarente,Raul Mostoslavsky,Aleksey Kazantsev
Publisher : Academic Press
Release : 2018-04-20
ISBN : 012813500X
Language : En, Es, Fr & De

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Book Description :

Introductory Review on Sirtuins in Biology and Disease provides key insights for scientists and advanced students who need to understand sirtuins and the current research in this field. This book is ideal for pharmaceutical companies as they develop novel targets using sirtuins for metabolic diseases, cancer and neurodegenerative illnesses. Sirtuins are a diverse family of proteins, with several members in mammals. The functional diversity of sirtuins is rather broad, and they have been implicated in various central biological processes. Thus, they are also highly relevant in the context of various human diseases, from cancer to neurodegeneration. Covers both the general and specific aspects of sirtuin proteins and their role in biology, aging and disease Presents a top quality collection of leading experts who contribute on a wide range of sirtuin-related topics Ideal resource for pharmaceutical companies as they develop novel targets using sirtuins for metabolic diseases, cancer and neurodegenerative illnesses

Sirtuin Biology in Medicine

Sirtuin Biology in Medicine Book
Author : Kenneth Maiese
Publisher : Academic Press
Release : 2021-03-04
ISBN : 0128141190
Language : En, Es, Fr & De

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Book Description :

Sirtuin Biology in Medicine: Targeting New Avenues of Care in Development, Aging, and Disease provides a fascinating and in-depth analysis of sirtuins in the body during normal physiology as well during disease highlighting the targeting of sirtuin-controlled pathways for the development of innovative, efficacious, and safe therapeutic strategies for multiple disorders in the body that ultimately can affect lifespan extension. Sirtuins are expressed throughout the body, have broad biological effects, and can significantly impact both cellular survival and longevity during acute and long-term illnesses. These histone deacetylases play an intricate role in the pathology, progression, and treatment of several disease entities ranging from neurodegenerative disorders, cardiovascular disease, immune system dysfunction, reproductive dysfunction, endocrine disorders, gastrointestinal disease, drug dependency, and aging-related disorders. Implementing a translational medicine format, this unique reference highlights novel signaling pathways for sirtuins that promote stem cell proliferation, enhance cellular protection, modulate pathways of apoptosis and autophagy, and extend life span. Each chapter is presented with insightful detail that will be of interest and a comprehensive resource to audiences that include scientists, physicians, pharmaceutical industry experts, nutritionists, and students. Chapters are authored by internationally recognized experts who discuss the broad role of sirtuins in health and disease Details the basic and clinical role of sirtuins for the development of new clinical treatments Summarizes the multidiscipline views and publications for the compelling discipline of sirtuins by covering systems throughout the body Serves as an important resource for a broad audience of healthcare providers, scientists, drug developers, and students in both clinical and research settings

Food and Lifestyle in Health and Disease

Food and Lifestyle in Health and Disease Book
Author : Chuong Pham-Huy,Bruno Pham Huy
Publisher : CRC Press
Release : 2022-04-25
ISBN : 1000563596
Language : En, Es, Fr & De

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Book Description :

This book discusses various types of food and lifestyles for the prevention and treatment of diseases and disorders, including cardiovascular disorders, cancers, neurodegenerative diseases, diabetes, hypertension, and obesity. Discusses influences of environmental pollution, synergistic effects of different foods, and synergy of foods with physical activity or medicine. Provides examples of plant source foods, animal source foods, fungal source foods and explains their roles in human health and disease. Links the relationships between food, lifestyle and health.

GeNeDis 2020

GeNeDis 2020 Book
Author : Panayiotis Vlamos
Publisher : Springer Nature
Release : 2022-01-12
ISBN : 3030787877
Language : En, Es, Fr & De

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Book Description :

The 4th World Congress on Genetics, Geriatrics, and Neurodegenerative Diseases Research (GeNeDis 2020) focuses on the latest major challenges in scientific research, new drug targets, the development of novel biomarkers, new imaging techniques, novel protocols for early diagnosis of neurodegenerative diseases, and several other scientific advances, with the aim of better, safer, and healthier aging. The relation between genetics and its effect on several diseases are thoroughly examined in this volume. This volume focuses on the sessions from the conference on Genetics and Neurodegenerative Diseases.

The Healthspan Solution

The Healthspan Solution Book
Author : Raymond J. Cronise,Julieanna Hever
Publisher : Penguin
Release : 2019-12-17
ISBN : 1465497595
Language : En, Es, Fr & De

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Book Description :

Increase your lifespan and optimize your health with plant-based recipes for a longer, more vibrant life. Authors and leading plant-based nutrition experts Julieanna Hever and Ray Cronise have spent over a decade researching diet and nutrition, analyzing longevity studies, and helping their clients achieve sustainable, lasting health benefits by adopting a whole food, plant-based diet. In The Healthspan Solution, they share the simple and effective diet that has allowed their clients to lose weight, reverse disease, reduce or eliminate medication use, and achieve optimal health. This accessible and easy-to-follow guide examines the health risks posed by typical Western eating habits and explains how a diet rich in vegetables, fruits, whole grains, legumes, mushrooms, nuts, seeds, herbs and spices can lead to lower blood pressure, healthy weight management, and longer life. Their flexible, customizable approach to eating challenges the conventional idea of breakfast, lunch, and dinner and focuses instead on soups, salads, sides, and sweets. With 100 delicious recipes to choose from, The Healthspan Solution make adopting a plant-based lifestyle simple and sustainable. Evidence-based research on the scientific underpinnings of the healthspan diet Easy-to-follow guidelines simplify food choices without being restrictive Beautifully photographed recipes offer options and flexibility Praise for The Healthspan Solution: "Ray and Julieanna didn't write a fad diet book. It's about making a permanent lifestyle transformation. The magic is I still can eat anything I want. The trick is what I want has profoundly changed. They did the trick for me and saved my life-now let them help you."-Penn Jillette, Las Vegas entertainer and magician "Ray is a scientific visionary and Julieanna is a master of nutrition. Together they've written a fact-based recipe book for longevity that belongs in every kitchen. Buy it."-David Sinclair, PhD, AO, Professor of Genetics, Harvard Medical School "Working with Julieanna and Ray has given me a profoundly new understanding of how food impacts health and how what we eat is often dictated by social influences. I'm excited to be a part of their effort to push to this message out to a far bigger audience."-Cyan Banister, angel investor and entrepreneur "Julieanna and Ray are an incredible team. While others have sought to demonstrate the adequacy of an exclusively plant-sourced diet, they teach how it can be superior and mimics longevity research."-Rich Roll, plant-powered ultra athlete and author

Lifespan

Lifespan Book
Author : David A. Sinclair,Matthew D. LaPlante
Publisher : Atria Books
Release : 2019-09-10
ISBN : 1501191977
Language : En, Es, Fr & De

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Book Description :

A NEW YORK TIMES BESTSELLER “Brilliant and enthralling.”​ —The Wall Street Journal A paradigm-shifting book from an acclaimed Harvard Medical School scientist and one of Time’s most influential people. It’s a seemingly undeniable truth that aging is inevitable. But what if everything we’ve been taught to believe about aging is wrong? What if we could choose our lifespan? In this groundbreaking book, Dr. David Sinclair, leading world authority on genetics and longevity, reveals a bold new theory for why we age. As he writes: “Aging is a disease, and that disease is treatable.” This eye-opening and provocative work takes us to the frontlines of research that is pushing the boundaries on our perceived scientific limitations, revealing incredible breakthroughs—many from Dr. David Sinclair’s own lab at Harvard—that demonstrate how we can slow down, or even reverse, aging. The key is activating newly discovered vitality genes, the descendants of an ancient genetic survival circuit that is both the cause of aging and the key to reversing it. Recent experiments in genetic reprogramming suggest that in the near future we may not just be able to feel younger, but actually become younger. Through a page-turning narrative, Dr. Sinclair invites you into the process of scientific discovery and reveals the emerging technologies and simple lifestyle changes—such as intermittent fasting, cold exposure, exercising with the right intensity, and eating less meat—that have been shown to help us live younger and healthier for longer. At once a roadmap for taking charge of our own health destiny and a bold new vision for the future of humankind, Lifespan will forever change the way we think about why we age and what we can do about it.

Handbook of the Biology of Aging

Handbook of the Biology of Aging Book
Author : Matt Kaeberlein,George Martin
Publisher : Academic Press
Release : 2015-08-20
ISBN : 0124116205
Language : En, Es, Fr & De

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Book Description :

Handbook of the Biology of Aging, Eighth Edition, provides readers with an update on the rapid progress in the research of aging. It is a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology, and focuses on the trend of ‘big data’ approaches in the biological sciences, presenting new strategies to analyze, interpret, and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and the metabolomics methodologies applied to aging related problems. The book includes discussions on longevity pathways and interventions that modulate aging, innovative new tools that facilitate systems-level approaches to aging research, the mTOR pathway and its importance in age-related phenotypes, new strategies to pharmacologically modulate the mTOR pathway to delay aging, the importance of sirtuins and the hypoxic response in aging, and how various pathways interact within the context of aging as a complex genetic trait, amongst others. Covers the key areas in biological gerontology research in one volume, with an 80% update from the previous edition Edited by Matt Kaeberlein and George Martin, highly respected voices and researchers within the biology of aging discipline Assists basic researchers in keeping abreast of research and clinical findings outside their subdiscipline Presents information that will help medical, behavioral, and social gerontologists in understanding what basic scientists and clinicians are discovering New chapters on genetics, evolutionary biology, bone aging, and epigenetic control Provides a close examination of the diverse research being conducted today in the study of the biology of aging, detailing recent breakthroughs and potential new directions

Oxidative Stress Antioxidants Transcription Factors and Assimilation of Signal Transduction Pathways in Obesity Related Disorders

Oxidative Stress  Antioxidants  Transcription Factors  and Assimilation of Signal Transduction Pathways in Obesity Related Disorders Book
Author : Terry D. Hinds, Jr,David E. Stec,Barbara Wegiel
Publisher : Frontiers Media SA
Release : 2021-10-21
ISBN : 2889715272
Language : En, Es, Fr & De

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Book Description :

Topic Editors Terry Hinds and David Stec have submitted patents related to bilirubin and obesity related disorders. The other Topic Editor declare no potential conflicts of interest with regards to the Research Topic subject.

Molecular Biology of Aging

Molecular Biology of Aging Book
Author : Leonard Guarente,Linda Partridge,Douglas C. Wallace
Publisher : CSHL Press
Release : 2008
ISBN : 0879698241
Language : En, Es, Fr & De

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Book Description :

This volume covers the major threads in the molecular genetics of aging, including genes that regulate aging, causes of aging, evolutionary theories of aging, and the relationship between diet and aging. Among specific topics covered are calorie restriction, mitochondria, sirtuins, telomeres, stem cells, and cancer.

Epigenetics and Dermatology

Epigenetics and Dermatology Book
Author : Qianjin Lu,Christopher C. Chang,Bruce C. Richardson
Publisher : Academic Press
Release : 2015-02-16
ISBN : 0128012722
Language : En, Es, Fr & De

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Book Description :

Epigenetics and Dermatology explores the role of epigenetics in the pathogenesis of autoimmune-related skin diseases and skin cancer. Leading contributors cover common and uncommon skin conditions in which extensive epigenetic research has been done. They explain how environmental exposures (chemicals, drugs, sunlight, diet, stress, smoking, infection, etc.) in all stages of life (from a fetus in-utero to an elderly person) may result in epigenetic changes that lead to development of some skin diseases in life. They also discuss the possibilities of new and emergent epigenetic treatments which are gradually being adopted in management of various skin diseases. Chapters follow a conventional structure, covering fundamental biology of the disease condition, etiology and pathogenesis, diagnosis, commonly available treatments, and epigenetic therapy where applicable. Discusses the basic biology of skin diseases and skin cancers induced or aggravated by aberrant epigenetic changes Evaluates how to approach autoimmune-related skin diseases from a therapeutic perspective using the wealth of emergent epigenetic clinical trials Offers a coherent and structured table of contents with basic epigenetic biology followed by discussion of the spectrum of rheumatologic through neoplastic skin diseases, finally ending with a discourse on epigenetic therapy

Borrowed Time

Borrowed Time Book
Author : Sue Armstrong
Publisher : Bloomsbury Publishing
Release : 2019-01-24
ISBN : 1472936078
Language : En, Es, Fr & De

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Book Description :

As featured on BBC Radio 4's Start the Week 'A rich, timely study for the era of "global ageing"' Nature The ageing of the world population is one of the most important issues facing humanity in the 21st century – up there with climate change in its potential global impact. Sometime before 2020, the number of people over 65 worldwide will, for the first time, be greater than the number of 0–4 year olds, and it will keep on rising. The strains this is causing on society are already evident as health and social services everywhere struggle to cope with the care needs of the elderly. But why and how do we age? Scientists have been asking this question for centuries, yet there is still no agreement. There are a myriad competing theories, from the idea that our bodies simply wear out with the rough and tumble of living, like well-worn shoes or a rusting car, to the belief that ageing and death are genetically programmed and controlled. In Borrowed Time, Sue Armstrong tells the story of science's quest to understand ageing and to prevent or delay the crippling conditions so often associated with old age. She focusses inward – on what is going on in our bodies at the most basic level of the cells and genes as the years pass – to look for answers to why and how our skin wrinkles with age, our wounds take much longer to heal than they did when we were kids, and why words escape us at crucial moments in conversation.This book explores these questions and many others through interviews with key scientists in the field of gerontology and with people who have interesting and important stories to tell about their personal experiences of ageing.

Gerontology

Gerontology Book
Author : Grazia D’Onofrio,Daniele Sancarlo,Antonio Greco
Publisher : BoD – Books on Demand
Release : 2018-07-04
ISBN : 178923252X
Language : En, Es, Fr & De

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Book Description :

Aging well and actively is the real objective of human being. This book is an up-to-date and realistic view on physiopathological mechanisms of aging and age-related diseases. The book includes topical contributions from multiple disciplines to support the fundamental goals of extending active life and enhancing its quality.

Anti Aging Drug Discovery on the Basis of Hallmarks of Aging

Anti Aging Drug Discovery on the Basis of Hallmarks of Aging Book
Author : Sandeep Kumar Singh,Chih Li Lin,Shailendra Kumar Mishra
Publisher : Academic Press
Release : 2022-07-29
ISBN : 0323902367
Language : En, Es, Fr & De

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Book Description :

Anti-Aging Drug Discovery on the Basis of Hallmarks of Aging is a comprehensive and timely book on all aspects of anti-aging strategies. The book provides comprehensive, foundational knowledge on the mechanisms of aging and current anti-aging strategies and approaches developed. Aging research has experienced an unprecedented advance over recent years with the discovery that the rate of aging is determined, at least to some extent, mainly by our genetics and modulated by environmental factors. The hallmarks of aging describe the molecular and cellular processes that govern biological aging and their variation in individuals. Covers different aspects of anti-aging research, from foundational knowledge to future perspectives Provides understanding on the different hallmarks of aging and how they can be applied in the development of anti-aging drugs Discusses various anti-aging strategies, including telomerase reactivation, clearance of senescent cells, stem cell-based therapy, and others

An Introduction to Gerontology

An Introduction to Gerontology Book
Author : Ian Stuart-Hamilton
Publisher : Cambridge University Press
Release : 2011-03-31
ISBN : 1139500171
Language : En, Es, Fr & De

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Book Description :

With the world's population getting increasingly older, there has never been a more pressing need for the study of old age and ageing. An Introduction to Gerontology provides a wide-ranging introduction to this important topic. By assuming no prior expert knowledge and avoiding jargon, this book will guide students through all the main subjects in gerontology, covering both traditional areas, such as biological and social ageing, and more contemporary areas, such as technology, the arts and sexuality. An Introduction to Gerontology is written by a team of international authors with multidisciplinary backgrounds who draw evidence from a variety of different perspectives and traditions.

Ageless Quest

Ageless Quest Book
Author : Lenny Guarente,Leonard Guarente
Publisher : CSHL Press
Release : 2003
ISBN : 9780879696528
Language : En, Es, Fr & De

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Book Description :

Ageless Questis a personal, sometimes controversial, account of the pursuit of a genetic †̃cure' for aging by an expert in the field. The author is the Novartis Professor of Biology at the Massachusetts Institute of Technology. Aging has always been regarded as a highly complex process with many degenerative changes leading to the cessation of life. But recent research has identified a relatively simple mechanism that governs the pace of aging. Lenny Guarente's Ageless Questis a scientific detective story for the baby boom generation. It offers an insider's view of an area of potentially astonishing high reward—and equally high risk.

Endothelial Dysfunction

Endothelial Dysfunction Book
Author : Helena Lenasi
Publisher : BoD – Books on Demand
Release : 2018-10-24
ISBN : 1789842530
Language : En, Es, Fr & De

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Book Description :

The endothelium enables communication between blood and tissues and is actively involved in cardiovascular homeostasis. Endothelial dysfunction has been recognized as an early step in the development of cardiovascular diseases: respectively, endothelium represents a potential therapeutic niche with multiple targets. The purpose of the book is to point out some recent findings of endothelial physiology and pathophysiology emphasizing various aspects of endothelial dysfunction connected to the body's internal and external environment. While basic features of the endothelium are presented in an introductory chapter, the authors of the following 17 chapters have provided extensive insight into some selected topics of endothelial (dys)function. The book would hopefully be useful for anyone interested in recapitulating endothelial (patho)physiology and expanding knowledge of molecular mechanisms involved in endothelial dysfunction, relevant also for further clinical investigations.

Sirtuins in Biology and Disease

Sirtuins in Biology and Disease Book
Author : Tiago F. Outeiro,Aleksey G. Kazantsev
Publisher : Frontiers E-books
Release : 2022-09-29
ISBN : 9782889191178
Language : En, Es, Fr & De

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Book Description :

Sirtuins comprise a family of NAD+-dependent enzymes that have been shown to impact longevity in a number of eukaryotic organisms. Sir2 (Silent Information Regulator 2) was the first sirtuin protein discovered. The discovery that Sir2 requires NAD+ for its activity suggested a link between Sir2 activity and the phenomenon of caloric restriction in prolonging longevity. This link was strengthened by the observation that lifespan extension by caloric restriction requires Sir2 protein. Under conditions of caloric restriction, NAD+ levels are high, Sir2 is activated, and the rate of aging is decreased. These effects have been replicated in invertebrate organisms, where a close structural and functional homologue of Sir2 was found in C. elegans and Drosophila. The sirtuin-dependent effects on metabolism and ageing, observed in lower organisms, have ignited intensive investigation of their biological and therapeutic roles in mammals. There are seven known mammalian sirtuins, SIRTs 1-7, the most studied of which is SIRT1, a close structural and functional homologue of yeast Sir2. Enhancement of organismal longevity and other health-promoting effects of mammalian SIRT1 have frequently been attributed to the regulation of metabolism. A recognized molecular link between metabolism and aging stimulated a firestorm of investigations, aiming to combat metabolic and age-dependent human diseases. It has become clear, however, that the sirtuin family of proteins regulates a diverse repertoire of cellular functions in mammals. Mounting evidence implicating SIRT1 in important clinical indications, such as diabetes, cancer, cardiovascular dysfunction and neurodegenerative disease, suggest that modality as attractive therapeutic target. Subsequently, drug discovery and development, targeting sirtuin activation, has been intensified in the recent years. Despite rapid progress and accumulation of new data, the biological roles of other mammalian sirtuins have been less studied and remain poorly understood. There are several important questions that remain to be addressed. What are the functions of sirtuins in different cell types and tissues? Are all sirtuins involved in the regulation of metabolism and aging? What is the functional relationship between different sirtuins? What are the mechanisms of regulation of sirtuin activities? What is the role of sirtuins in disease and therapy? This issue aims to address these and other critical questions, relevant to Research Topic on sirtuin biology and therapeutics. To that end the issue solicits expert opinions of sirtuin research on structural biology, biochemistry, cell biology, animal genetics, pharmacology, medicinal chemistry and drug discovery, and on areas of investigation studying human conditions, like diabetes, cancer, cardio-vascular, and neutodegeneration. Of particular interest are the new methods and assays to study sirtuins in various organisms and developing sirtuin-based therapeutics. Furthermore, we propose to encourage contributors to discuss new concepts and paradigms, and to express their perspectives on the future development of the sirtuin research field. Altogether, we believe this issue provides a unique opportunity for comprehensive and diverse coverage of the topic, and will be of broad interest for the journal’s readership.

Biochemistry and Cell Biology of Ageing Part II Clinical Science

Biochemistry and Cell Biology of Ageing  Part II Clinical Science Book
Author : J. Robin Harris,Viktor I. Korolchuk
Publisher : Springer
Release : 2019-03-19
ISBN : 9811336814
Language : En, Es, Fr & De

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Book Description :

This volume of the subcellular Biochemistry series will attempt to bridge the gap between the subcellular events that are related to aging as they were described in the first volume of this set of two books and the reality of aging as this is seen in clinical practice. All chapters will start from the biochemistry or cell biology, where the data is available and work up towards the understanding that we have of aging in the various areas that are related to the subject. Key focus points for this volume are nutrition, external factors and genetics on aging. There will also be chapters that will focus on various organs or tissues in which aging has been well studied, like the eyes, the muscles, the immune system and the bones. The aim of the book project and the book project that is published in concert with this volume is to bring the subcellular and clinical areas into closer contact.

Neurobiology of Huntington s Disease

Neurobiology of Huntington   s Disease Book
Author : Donald C. Lo,Robert E. Hughes
Publisher : CRC Press
Release : 2010-07-02
ISBN : 1420008250
Language : En, Es, Fr & De

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Book Description :

In 1993, the genetic mutation responsible for Huntington’s disease (HD) was identified. Considered a milestone in human genomics, this discovery has led to nearly two decades of remarkable progress that has greatly increased our knowledge of HD, and documented an unexpectedly large and diverse range of biochemical and genetic perturbations that seem to result directly from the expression of the mutant huntingtin gene. Neurobiology of Huntington’s Disease: Applications to Drug Discovery presents a thorough review of the issues surrounding drug discovery and development for the treatment of this paradigmatic neurodegenerative disease. Drawing on the expertise of key researchers in the field, the book discusses the basic neurobiology of Huntington’s disease and how its monogenic nature confers enormous practical advantages for translational research, including the creation of robust experimental tools, models, and assays to facilitate discovery and validation of molecular targets and drug candidates for HD. Written to support future basic research as well as drug development efforts, this volume: Covers the latest research approaches in genetics, genomics, and proteomics, including high-throughput and high-content screening Highlights advances in the discovery and development of new drug therapies for neurodegenerative disorders Examines the practical realities of preclinical testing, clinical testing strategies, and, ultimately, clinical usage While the development of effective drug treatments for Huntington's disease continues to be tremendously challenging, a highly interactive and cooperative community of researchers and clinical investigators now brings us to the threshold of potential breakthroughs in the quest for therapeutic agents. The impressive array of drug discovery resources outlined in the text holds much promise for treating this devastating disease, providing hope to long-suffering Huntington’s disease patients and their families.

Reviews on Biomarker Studies in Aging and Anti Aging Research

Reviews on Biomarker Studies in Aging and Anti Aging Research Book
Author : Paul C. Guest
Publisher : Springer Nature
Release : 2019-09-06
ISBN : 3030256502
Language : En, Es, Fr & De

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Book Description :

Using both epidemiological and model organism approaches, we have gained new insights into the physiological and molecular aspects of aging, which has led to significant advancements in potential anti-aging strategies. Reviews on Biomarker Studies in Aging and Anti-Aging Research presents a series of reviews in various aspects of aging and age-related disease research along with several methods which have shown progress as potential anti-aging approaches. The book is aimed at researchers in the areas of aging and chronic disease, as well as to clinical scientists, physicians and major drug companies. It provides important information on disease mechanisms, and each chapter is presented in the context of the aging process, specific chronic diseases or different therapeutic areas.