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Introductory Review On Sirtuins In Biology Aging And Disease

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Introductory Review on Sirtuins in Biology Aging and Disease

Introductory Review on Sirtuins in Biology  Aging  and Disease Book
Author : Leonard Guarente,Raul Mostoslavsky,Aleksey Kazantsev
Publisher : Academic Press
Release : 2018-04-20
ISBN : 012813500X
Language : En, Es, Fr & De

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Book Description :

Introductory Review on Sirtuins in Biology and Disease provides key insights for scientists and advanced students who need to understand sirtuins and the current research in this field. This book is ideal for pharmaceutical companies as they develop novel targets using sirtuins for metabolic diseases, cancer and neurodegenerative illnesses. Sirtuins are a diverse family of proteins, with several members in mammals. The functional diversity of sirtuins is rather broad, and they have been implicated in various central biological processes. Thus, they are also highly relevant in the context of various human diseases, from cancer to neurodegeneration. Covers both the general and specific aspects of sirtuin proteins and their role in biology, aging and disease Presents a top quality collection of leading experts who contribute on a wide range of sirtuin-related topics Ideal resource for pharmaceutical companies as they develop novel targets using sirtuins for metabolic diseases, cancer and neurodegenerative illnesses

The Healthspan Solution

The Healthspan Solution Book
Author : Raymond J. Cronise,Julieanna Hever
Publisher : Penguin
Release : 2019-12-17
ISBN : 1465497595
Language : En, Es, Fr & De

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Book Description :

Increase your lifespan and optimize your health with plant-based recipes for a longer, more vibrant life. Authors and leading plant-based nutrition experts Julieanna Hever and Ray Cronise have spent over a decade researching diet and nutrition, analyzing longevity studies, and helping their clients achieve sustainable, lasting health benefits by adopting a whole food, plant-based diet. In The Healthspan Solution, they share the simple and effective diet that has allowed their clients to lose weight, reverse disease, reduce or eliminate medication use, and achieve optimal health. This accessible and easy-to-follow guide examines the health risks posed by typical Western eating habits and explains how a diet rich in vegetables, fruits, whole grains, legumes, mushrooms, nuts, seeds, herbs and spices can lead to lower blood pressure, healthy weight management, and longer life. Their flexible, customizable approach to eating challenges the conventional idea of breakfast, lunch, and dinner and focuses instead on soups, salads, sides, and sweets. With 100 delicious recipes to choose from, The Healthspan Solution make adopting a plant-based lifestyle simple and sustainable. Evidence-based research on the scientific underpinnings of the healthspan diet Easy-to-follow guidelines simplify food choices without being restrictive Beautifully photographed recipes offer options and flexibility Praise for The Healthspan Solution: "Ray and Julieanna didn't write a fad diet book. It's about making a permanent lifestyle transformation. The magic is I still can eat anything I want. The trick is what I want has profoundly changed. They did the trick for me and saved my life-now let them help you."-Penn Jillette, Las Vegas entertainer and magician "Ray is a scientific visionary and Julieanna is a master of nutrition. Together they've written a fact-based recipe book for longevity that belongs in every kitchen. Buy it."-David Sinclair, PhD, AO, Professor of Genetics, Harvard Medical School "Working with Julieanna and Ray has given me a profoundly new understanding of how food impacts health and how what we eat is often dictated by social influences. I'm excited to be a part of their effort to push to this message out to a far bigger audience."-Cyan Banister, angel investor and entrepreneur "Julieanna and Ray are an incredible team. While others have sought to demonstrate the adequacy of an exclusively plant-sourced diet, they teach how it can be superior and mimics longevity research."-Rich Roll, plant-powered ultra athlete and author

Sirtuins in Biology and Disease

Sirtuins in Biology and Disease Book
Author : Tiago F. Outeiro,Aleksey G. Kazantsev
Publisher : Frontiers E-books
Release : 2020-12-02
ISBN : 9782889191178
Language : En, Es, Fr & De

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Book Description :

Sirtuins comprise a family of NAD+-dependent enzymes that have been shown to impact longevity in a number of eukaryotic organisms. Sir2 (Silent Information Regulator 2) was the first sirtuin protein discovered. The discovery that Sir2 requires NAD+ for its activity suggested a link between Sir2 activity and the phenomenon of caloric restriction in prolonging longevity. This link was strengthened by the observation that lifespan extension by caloric restriction requires Sir2 protein. Under conditions of caloric restriction, NAD+ levels are high, Sir2 is activated, and the rate of aging is decreased. These effects have been replicated in invertebrate organisms, where a close structural and functional homologue of Sir2 was found in C. elegans and Drosophila. The sirtuin-dependent effects on metabolism and ageing, observed in lower organisms, have ignited intensive investigation of their biological and therapeutic roles in mammals. There are seven known mammalian sirtuins, SIRTs 1-7, the most studied of which is SIRT1, a close structural and functional homologue of yeast Sir2. Enhancement of organismal longevity and other health-promoting effects of mammalian SIRT1 have frequently been attributed to the regulation of metabolism. A recognized molecular link between metabolism and aging stimulated a firestorm of investigations, aiming to combat metabolic and age-dependent human diseases. It has become clear, however, that the sirtuin family of proteins regulates a diverse repertoire of cellular functions in mammals. Mounting evidence implicating SIRT1 in important clinical indications, such as diabetes, cancer, cardiovascular dysfunction and neurodegenerative disease, suggest that modality as attractive therapeutic target. Subsequently, drug discovery and development, targeting sirtuin activation, has been intensified in the recent years. Despite rapid progress and accumulation of new data, the biological roles of other mammalian sirtuins have been less studied and remain poorly understood. There are several important questions that remain to be addressed. What are the functions of sirtuins in different cell types and tissues? Are all sirtuins involved in the regulation of metabolism and aging? What is the functional relationship between different sirtuins? What are the mechanisms of regulation of sirtuin activities? What is the role of sirtuins in disease and therapy? This issue aims to address these and other critical questions, relevant to Research Topic on sirtuin biology and therapeutics. To that end the issue solicits expert opinions of sirtuin research on structural biology, biochemistry, cell biology, animal genetics, pharmacology, medicinal chemistry and drug discovery, and on areas of investigation studying human conditions, like diabetes, cancer, cardio-vascular, and neutodegeneration. Of particular interest are the new methods and assays to study sirtuins in various organisms and developing sirtuin-based therapeutics. Furthermore, we propose to encourage contributors to discuss new concepts and paradigms, and to express their perspectives on the future development of the sirtuin research field. Altogether, we believe this issue provides a unique opportunity for comprehensive and diverse coverage of the topic, and will be of broad interest for the journal’s readership.

Clocks and Rhythms

Clocks and Rhythms Book
Author : Cold Spring Harbor Laboratory
Publisher : CSHL Press
Release : 2007
ISBN : 0879698233
Language : En, Es, Fr & De

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Book Description :

Based on presentations by world–renowned investigators at the 72nd annual Cold Spring Harbor Symposium on Quantitative Biology, this volume reviews the latest advances in biological clocks and rhythms. Topics include genetic and cellular studies aimed at characterizing circadian mechanisms; systems approaches to understanding physiological, endocrine, and neural networks; and models used for studying mental and physical cycles. A variety of normal and abnormal chronobiological patterns are discussed, including sleep, aging, migration, hibernation, seasonality, depression, and arrhythmias.

Transcriptional Gene Regulation in Health and Disease

Transcriptional Gene Regulation in Health and Disease Book
Author : Anonim
Publisher : Academic Press
Release : 2018-01-15
ISBN : 0128123400
Language : En, Es, Fr & De

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Book Description :

Transcriptional Gene Regulation in Health and Disease, Volume 335, the latest release in the International Review of Cell and Molecular Biology reviews and details current advances in cell and molecular biology. The IRCMB series has a worldwide readership, maintaining a high standard by publishing invited articles on important and timely topics that are authored by prominent cell and molecular biologists. The articles published in IRCMB have a high impact and an average cited half-life of nine years. This great resource ranks high amongst scientific journals dealing with cell biology. Publishes only invited review articles on selected topics Authored by established and active cell and molecular biologists drawn from international sources Offers a wide range of perspectives on specific subjects

Psychology of Aging

Psychology of Aging Book
Author : Brian Yochim, PhD, ABPP,Erin Woodhead, PhD
Publisher : Springer Publishing Company
Release : 2017-12-28
ISBN : 0826137296
Language : En, Es, Fr & De

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Book Description :

"The book goes well beyond the information in undergraduate texts and provides stimulating and useful coverage of key topics in biopsychosocial aging. Psychology is not prepared for the future growth of our older adult population, and I suggest Psychology of Aging: A Biopsychosocial Perspective as required reading for students" --William E. Haley, PhD; Professor; School of Aging Studies; College of Behavioral and Community Sciences, Tampa, FL "This book distinguishes itself from previous publications on the topic with a thorough review of the history profession of geropsychology and its timely inclusion of chapters on brain imaging techniques and the aging brain, cultural differences in aging ethnic and sexual minorities, cognitive interventions, and more. This book is a must read for undergraduate and graduate students studying aging, and one I will definitely recommend to students new to the area."--Sherry A. Beaudreau, Ph.D., ABPP, VA Palo Alto Health Care System and Stanford University School of Medicine "Brian Yochim and Erin Woodhead have created an invaluable tool for learning about and teaching geropsychology...This book will serve as a seminal text in training psychologists, social workers, and many other disciplines in the psychology of aging." --Erin E. Emery-Tiburcio, Ph.D., ABPP, Rush University, Chicago, IL The only graduate text to encompass the full range of issues regarding the psychology of aging This is the first graduate-level text that offers a comprehensive, in-depth chronicle of issues surrounding the psychology of aging emphasizing psychology, with a foundation in the biology, and an expansion into the sociological aspects of aging. The text is divided into three sections: biological underpinnings of aging, psychological components of aging, and social aspects of aging. Among the multitude of topics addressed are biological theories of aging, neuroimaging methods in aging research, neuroplasticity, cognitive reserve and cognitive interventions, a detailed overview of neurocognitive disorders in aging such as Alzheimer's disease and Lewy body disease, relationships in aging, work vs. retirement, cultural issues in aging, and aging and the legal system, to name just a few critical topics. With an emphasis on promoting critical thinking, the text is enriched with discussion questions in each chapter along with suggestions for more in-depth readings. In addition it includes chapter PowerPoints and an Instructor’s Manual with sample syllabi for a 10-week course and a 15-week course. Written for graduate students in multiple gerontology-related disciplines, the text is also of value to individuals studying nursing, medicine, social work, biology, and occupational, physical, and speech therapies. Key Features: Addresses the biological underpinnings of aging, psychological components, and social aspects Written by a variety of experts on each area Emphasizes critical thinking throughout the text Presents discussion questions in each chapter Includes PowerPoints and an Instructor’s Manual with sample syllabi Tailored to graduate students from multiple disciplines embarking on clinical or research careers involving older adults.

Advances in Cancer Research

Advances in Cancer Research Book
Author : George F. Vande Woude,George Klein
Publisher : Academic Press
Release : 2009-09-12
ISBN : 9780080922331
Language : En, Es, Fr & De

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Book Description :

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics, including tumor dormancy, micro RNA, tumor angiogenesis, cancer in mouse models, liposome based chemo and autoimmunotherapy, signaling in angiogenesis, targeted cancer therapy, and regulatory t-cells.

The Biology of Senescence

The Biology of Senescence Book
Author : Bernard Swynghedauw
Publisher : Springer
Release : 2019-06-06
ISBN : 3030151115
Language : En, Es, Fr & De

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Book Description :

This book describes the fundamental process of senescence, and reviews a new concept developed by a number of research groups that is based on cellular senescence and its secretome. This concept provides a basic explanation of the main physiological and pathological features of senescence, and delineates possibilities for “treating” it. Following an introduction to the emerging medical landscape, the increasing incidence of a new epidemiological group (age-related “chronic non-transmissible diseases”), and the multiple origins of aging, the book explores and characterizes the senescent cell, which is linked to benign and pathological age-related manifestations. In turn, the closing chapters discuss how to “treat” or “prevent” the aging process, underscoring the central role of physical exercise and caloric reduction as compared to new senolytic approaches. Appendices are also provided, and address circadian rhythms, telomere shortening, diabetic cardiomyopathy, and senescence in plants and bacteria. Given its scope, the book will primarily be of interest to geriatricians, but will also appeal to a wider range of clinicians.

Issues in Geriatric Medicine and Aging Research 2011 Edition

Issues in Geriatric Medicine and Aging Research  2011 Edition Book
Author : Anonim
Publisher : ScholarlyEditions
Release : 2012-01-09
ISBN : 146496498X
Language : En, Es, Fr & De

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Book Description :

Issues in Geriatric Medicine and Aging Research: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Geriatric Medicine and Aging Research. The editors have built Issues in Geriatric Medicine and Aging Research: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Geriatric Medicine and Aging Research in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Geriatric Medicine and Aging Research: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

You Staying Young

You  Staying Young Book
Author : Michael F. Roizen,Mehmet Oz
Publisher : Simon and Schuster
Release : 2007-10-30
ISBN : 141655405X
Language : En, Es, Fr & De

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Book Description :

The body is the most fascinating machine ever created, and nobody talks about it in ways that are as illuminating and compelling as Dr. Michael Roizen and Dr. Mehmet Oz. Most people think of the aging of our bodies the same way we think of the aging of our cars: the older we get, the more inevitable it is that we're going to break down. Most of us believe that at age 40 or so, we begin the slow and steady decline of our minds, our eyes, our ears, our joints, our arteries, our libido, and every other system that affects the quality of life (and how long we live it). But according to Dr. Roizen and Dr. Oz, that's a mistake. Aging isn't a decline in our systems. It's actually very purposeful. The very systems and biological processes that age us are designed to help us when we're a little bit younger. So what's our role as part of the aging population? To learn how those systems work so we can reprogram them to work the way they did when we were younger. Your goal should be: die young at any age. That means you live a high quality of life (with everything from working joints to working genitals) until the day you die. At the core of this landmark book are the Major Agers -- 14 biological processes that control your rate of aging. Some you've heard of, some you haven't, and some you never knew contributed to the aging process. Some speed decline, others inhibit your repair mechanisms. These Major Agers are everything from short telomeres and inefficient mitochondria to stem cells and wacky hormones. The doctors explain the principles of longevity and many of the causes of aging and how to fight the effects. The climax of the book is a 14-day plan to help you along your path to staying young. The doctors want you to be able to integrate important processes into your daily life in order to make staying young routine, but first you'll need to measure your real age and health right now. Staying young encompasses your emotions and mental health as well as your exercise habits, eating habits, personal hygiene, and genes, among other things. Wouldn't you like to know how to prevent your body from aging badly? The original YOU book showed how bodies work in general, and YOU: On a Diet explained how bodies lose weight and stay fit. Now in YOU: Staying Young, Drs. Michael Roizen and Mehmet Oz illuminate the mysterious mechanisms with a lively metaphor -- the modern city. What differentiates a vibrant and thriving city that ages gracefully from one that is worn down and rusted out? Despite genetic differences, which are like the geography upon which the city is built, cities age differently because of the way residents treat their education system (stem cells), power plants (mitochondria), electrical grids (brains), transportation routes (blood vessels), and landfills (fat). You -- as mayor, resident, and street cleaner -- have the power to balance your biological budget to ensure a life that's both long and strong. Thankfully, just as cities can invest in renewal and improving their repair processes, so can you. YOU: Staying Young is filled with signature YOU Tools, including YOU Tests, YOU Tips, and visual and verbal metaphors to bring the science to life.

SUMMARY Lifespan Why We Age and Why We Don t Have To By David Sinclair The MW Summary Guide

SUMMARY  Lifespan  Why We Age   and Why We Don t Have To  By David Sinclair   The MW Summary Guide Book
Author : The Mindset Warrior
Publisher : KP
Release : 101-01-01
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

An Easy to Digest Summary Guide... ★☆BONUS MATERIAL AVAILABLE INSIDE★☆ The Mindset Warrior Summary Guides, provides you with a unique summarized version of the core information contained in the full book, and the essentials you need in order to fully comprehend and apply. Maybe you've read the original book but would like a reminder of the information? ✅ Maybe you haven't read the book, but want a short summary to save time? ✅ Maybe you'd just like a summarized version to refer to in the future? ✅ In any case, The Mindset Warrior Summary Guides can provide you with just that. Inside You'll Learn: ✱ Things in your environment—right now—that are rapidly aging you. What they are & What to do about them... ✱ Why protein isn't all it's cracked up to be, and how you should cycle it to maximize longevity. ✱ The supplements and medicines that are available (and still in development) that will allow you to easily live 6 - 10 years longer. ✱ In the U.S., about 85,000 people are misdiagnosed each year. Learn why that is and why in the future this won't be a problem. ✱ A behind the scenes look into what treatments are in development to help eradicate disease and cancer. And what you can start doing today to protect yourself. Lets get Started. Download Your Book Today... NOTE: To Purchase the "Lifespan"(full book); which this is not, simply type in the name of the book in the search bar of your bookstore.

The CR Way

The CR Way Book
Author : Paul McGlothin,Meredith Averill
Publisher : Harper Collins
Release : 2008-07-08
ISBN : 9780061734304
Language : En, Es, Fr & De

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Book Description :

When it comes to living longer, scientists are discovering that less is more. By following Calorie Restriction, a revolutionary diet that provides the body with fewer calories than is traditionally required, people are getting dramatic benefits. Now, with The CR Way, you too can slow the aging process; protect against cardiovascular disease, cancer, and diabetes; and increase your energy and mental capabilities. And, if needed, you'll lose weight and keep it off. Paul McGlothin and Meredith Averill, leaders of the Calorie Restriction Society, provide quick and easy menus and recipes so delicious that you will wonder why you ever wanted to eat more than you need. And for those who want some of the benefits without sacrificing all the calories, the authors will show you how to plan a diet that works for you. Groundbreaking and controversial, The CR Way is your key to a happier, healthier life.

Issues in Discovery Experimental and Laboratory Medicine 2011 Edition

Issues in Discovery  Experimental  and Laboratory Medicine  2011 Edition Book
Author : Anonim
Publisher : ScholarlyEditions
Release : 2012-01-09
ISBN : 1464963509
Language : En, Es, Fr & De

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Book Description :

Issues in Discovery, Experimental, and Laboratory Medicine: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Discovery, Experimental, and Laboratory Medicine. The editors have built Issues in Discovery, Experimental, and Laboratory Medicine: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Discovery, Experimental, and Laboratory Medicine in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Discovery, Experimental, and Laboratory Medicine: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Issues in Pharmacology Pharmacy Drug Research and Drug Innovation 2011 Edition

Issues in Pharmacology  Pharmacy  Drug Research  and Drug Innovation  2011 Edition Book
Author : Anonim
Publisher : ScholarlyEditions
Release : 2012-01-09
ISBN : 1464963444
Language : En, Es, Fr & De

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Book Description :

Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Pharmacology, Pharmacy, Drug Research, and Drug Innovation. The editors have built Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Pharmacology, Pharmacy, Drug Research, and Drug Innovation in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Cancer New Insights for the Healthcare Professional 2011 Edition

Cancer  New Insights for the Healthcare Professional  2011 Edition Book
Author : Anonim
Publisher : ScholarlyEditions
Release : 2012-01-09
ISBN : 1464900027
Language : En, Es, Fr & De

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Book Description :

Cancer: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Cancer. The editors have built Cancer: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Cancer in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Cancer: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.