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Introduction To Diffusion Tensor Imaging

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Introduction to Diffusion Tensor Imaging

Introduction to Diffusion Tensor Imaging Book
Author : Susumu Mori
Publisher : Elsevier Science Limited
Release : 2007
ISBN : 9780444528285
Language : En, Es, Fr & De

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Book Description :

The concept of Diffusion Tensor Imaging (DTI) is often difficult to grasp, even for Magnetic Resonance physicists. Introduction to Diffusion Tensor Imaging uses extensive illustrations (not equations) to help readers to understand how DTI works. Emphasis is placed on the interpretation of DTI images, the design of DTI experiments, and the forms of application studies. The theory of DTI is constantly evolving and so there is a need for a textbook that explains how the technique works in a way that is easy to understand - Introduction to Diffusion Tensor Imaging fills this gap. * Uses extensive illustrations to explain the concept of Diffusion Tensor Imaging * Easy to understand, even without a background in physics * Includes sections on image interpretation, experimental design and applications

Introduction to Diffusion Tensor Imaging

Introduction to Diffusion Tensor Imaging Book
Author : Susumu Mori,J-Donald Tournier
Publisher : Academic Press
Release : 2013-08-02
ISBN : 0123984076
Language : En, Es, Fr & De

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Book Description :

The concepts behind diffusion tensor imaging (DTI) are commonly difficult to grasp, even for magnetic resonance physicists. To make matters worse, a many more complex higher-order methods have been proposed over the last few years to overcome the now well-known deficiencies of DTI. In Introduction to Diffusion Tensor Imaging: And Higher Order Models, these concepts are explained through extensive use of illustrations rather than equations to help readers gain a more intuitive understanding of the inner workings of these techniques. Emphasis is placed on the interpretation of DTI images and tractography results, the design of experiments, and the types of application studies that can be undertaken. Diffusion MRI is a very active field of research, and theories and techniques are constantly evolving. To make sense of this constantly shifting landscape, there is a need for a textbook that explains the concepts behind how these techniques work in a way that is easy and intuitive to understand—Introduction to Diffusion Tensor Imaging fills this gap. Extensive use of illustrations to explain the concepts of diffusion tensor imaging and related methods Easy to understand, even without a background in physics Includes sections on image interpretation, experimental design, and applications Up-to-date information on more recent higher-order models, which are increasingly being used for clinical applications

Diffusion Tensor Imaging

Diffusion Tensor Imaging Book
Author : Bram Stieltjes,Romuald M. Brunner,Klaus Fritzsche,Frederik Laun
Publisher : Springer Science & Business Media
Release : 2013-02-14
ISBN : 3642204562
Language : En, Es, Fr & De

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Book Description :

Diffusion Tensor Imaging (DTI) is a variation of diffusion-weighed imaging. Particularly in the neurosciences, this technique has gained tremendous momentum in the past decade, both from a technical point of view as well as in its applications. DTI is mainly used in neurological diagnosis and psychiatric and neurologic research, e.g. in order to locate brain tumors and depict their invasivity. DTI offers a unique in-vivo insight into the three-dimensional structure of the human central nervous system. While easy interpretation and evaluation is often hampered by the complexity of both the technique and neuroanatomy, this atlas helps you recognize every one of the important structures rapidly and unambiguously. In the introduction, this atlas provides a concise outline of the evolution of diffusion imaging and describes its potential applications. In the core part of the atlas, the neuroanatomically important structures are clearly labeled both on DTI-derived color maps and conventional MRI. Complex fiber architecture is illustrated schematically and described concisely in textboxes directly on the relevant page. In the final part of the atlas, a straightforward, step-by-step approach for the three-dimensional reconstruction of the most prominent fiber structures is given, and potential pitfalls are indicated. The atlas aims at neuroscientists, neuoanatomists, neurologists, psychiatrists, clinical psychologists, physicists, and computer scientists. For advanced users, the atlas may serve as a reference work, while students and scientists are thoroughly introduced in DTI.

Introduction to Diffusion Tensor Imaging

Introduction to Diffusion Tensor Imaging Book
Author : Susumu Mori
Publisher : Elsevier
Release : 2007-05-17
ISBN : 9780080495767
Language : En, Es, Fr & De

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Book Description :

The concept of Diffusion Tensor Imaging (DTI) is often difficult to grasp, even for Magnetic Resonance physicists. Introduction to Diffusion Tensor Imaging uses extensive illustrations (not equations) to help readers to understand how DTI works. Emphasis is placed on the interpretation of DTI images, the design of DTI experiments, and the forms of application studies. The theory of DTI is constantly evolving and so there is a need for a textbook that explains how the technique works in a way that is easy to understand - Introduction to Diffusion Tensor Imaging fills this gap. * Uses extensive illustrations to explain the concept of Diffusion Tensor Imaging * Easy to understand, even without a background in physics * Includes sections on image interpretation, experimental design and applications

Statistical Diffusion Tensor Imaging From Data Quality to Fiber Tracking

Statistical Diffusion Tensor Imaging  From Data Quality to Fiber Tracking Book
Author : Susanne Heim
Publisher : Cuvillier Verlag
Release : 2007-08-09
ISBN : 3736923260
Language : En, Es, Fr & De

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Book Description :

Magnetic resonance diffusion tensor imaging (DTI) allows to infere the ultrastructure of living tissue. In brain mapping, neural fiber trajectories can be identified by exploiting the anisotropy of diffusion processes. Manifold statistical methods may be linked into the comprehensive processing chain that is spanned between DTI raw images and the reliable visualization of fibers. In this work, a space varying coefficients model (SVCM) using penalized B-splines was developed to integrate diffusion tensor estimation, regularization and interpolation into a unified framework. The implementation challenges originating in multiple 3d space varying coefficient surfaces and the large dimensions of realistic datasets were met by incorporating matrix sparsity and efficient model approximation. Superiority of B-spline based SVCM to the standard approach was demonstrable from simulation studies in terms of the precision and accuracy of the individual tensor elements. The integration with a probabilistic fiber tractography algorithm and application on real brain data revealed that the unified approach is at least equivalent to the serial application of voxelwise estimation, smoothing and interpolation. From the error analysis using boxplots and visual inspection the conclusion was drawn that both the standard approach and the B-spline based SVCM may suffer from low local adaptivity. Therefore, wavelet basis functions were employed for filtering diffusion tensor fields. While excellent local smoothing was indeed achieved by combining voxelwise tensor estimation with wavelet filtering, no immediate improvement was gained for fiber tracking. However, the thresholding strategy needs to be refined and the proposed model of an incorporation of wavelets into an SVCM needs to be implemented to finally assess their utility for DTI data processing. In summary, an SVCM with specific consideration of the demands of human brain DTI data was developed and implemented, eventually representing a unified postprocessing framework. This represents an experimental and statistical platform to further improve the reliability of tractography. The reader might find Chapters 1 and 4 particularly useful for a concise introduction to magnetic resonance imaging and to wavelet theory. The SVCM model was implemented in R and is available online as package of the same name.

MRI Atlas of Human White Matter

MRI Atlas of Human White Matter Book
Author : Susumu Mori,S. Wakana,Peter C M van Zijl,L.M. Nagae-Poetscher
Publisher : Elsevier
Release : 2005-05-11
ISBN : 9780080456164
Language : En, Es, Fr & De

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Book Description :

Recent advances in modern imaging techniques that can be used non-invasively for the visualization of the human brain have greatly enhanced the knowledge of brain anatomy and the understanding of its relationship to brain function. A unique new MRI modality, called diffusion tensor imaging (DTI) allows the three-dimensional study of the large white matter (WM) fiber bundles at macroscopic resolution (millimeter scale). MRI Atlas of Human White Matter provides a three-dimensional and two-dimensional in vivo atlas of various white matter tracts in the human brain. The images are based on diffusion tensor imaging and various tracts are reconstructed three-dimensionally from the data. Following an introduction and description of the methodology (Chapters 1 and 2), the 3D anatomy of individual tracts is delineated in Chapter 3. Chapter 4 consists of a series of color-coded orientation maps to delineate white matter anatomy in a slice-by-slice manner, in which the structures are extensively annotated. This richly illustrated Atlas is a valuable resource for students studying white matter anatomy and researchers working in brain research and radiology. This book also provides the structural assignment, which will assist neuroradiologists when interpreting diffusion tensor images in routine clinical studies. * Contains information demonstrating the clear separation of grey matter and white matter structures in the living human brain * 3D white matter tract reconstruction, with extensive 2D panels in all three viewing angles * Comprehensive annotations of white matter structures

Diffusion Tensor MRI of Human Ischaemic Stroke

Diffusion Tensor MRI of Human Ischaemic Stroke Book
Author : Susana Muñoz Maniega,Mark Bastin
Publisher : Unknown
Release : 2007
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The value of diffusion-weighted magnetic resonance imaging (DW-MRI) for early diagnosis of human ischaemic stroke has triggered the rapid development of this imaging technique. The introduction of the diffusion tensor (DT) model provides a range of tools that permit the quantitative assessment of this and many other neurological disorders. This thesis addresses some of the methodological issues encountered when using DT-MRI to image acute stroke patients.

Functional Neuroradiology

Functional Neuroradiology Book
Author : Scott H. Faro,Feroze B. Mohamed,Meng Law,John T. Ulmer
Publisher : Springer Science & Business Media
Release : 2011-09-08
ISBN : 9781441903457
Language : En, Es, Fr & De

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Book Description :

Functional Neuroradiology: Principles and Clinical Applications, is a follow-up to Faro and Mohamed’s groundbreaking work, Functional (BOLD)MRI: Basic Principles and Clinical Applications. This new 49 chapter textbook is comprehensive and offers a complete introduction to the state-of-the-art functional imaging in Neuroradiology, including the physical principles and clinical applications of Diffusion, Perfusion, Permeability, MR spectroscopy, Positron Emission Tomography, BOLD fMRI and Diffusion Tensor Imaging. With chapters written by internationally distinguished neuroradiologists, neurologists, psychiatrists, cognitive neuroscientists, and physicists, Functional Neuroradiology is divided into 9 major sections, including: Physical principles of all key functional techniques, Lesion characterization using Diffusion, Perfusion, Permeability, MR spectroscopy, and Positron Emission Tomography, an overview of BOLD fMRI physical principles and key concepts, including scanning methodologies, experimental research design, data analysis, and functional connectivity, Eloquent Cortex and White matter localization using BOLD fMRI and Diffusion Tensor Imaging, Clinical applications of BOLD fMRI in Neurosurgery, Neurology, Psychiatry, Neuropsychology, and Neuropharmacology, Multi-modality functional Neuroradiology, Beyond Proton Imaging, Functional spine and CSF imaging, a full-color Neuroanatomical Brain atlas of eloquent cortex and key white matter tracts and BOLD fMRI paradigms. By offering readers a complete overview of functional imaging modalities and techniques currently used in patient diagnosis and management, as well as emerging technology, Functional Neuroradiology is a vital information source for physicians and cognitive neuroscientists involved in daily practice and research.

Diffusion Tensor Imaging

Diffusion Tensor Imaging Book
Author : Wim Van Hecke,Louise Emsell,Stefan Sunaert
Publisher : Springer
Release : 2015-12-14
ISBN : 1493931180
Language : En, Es, Fr & De

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Book Description :

This book provides an overview of the practical aspects of diffusion tensor imaging (DTI), from understanding the basis of the technique through selection of the right protocols, trouble-shooting data quality, and analyzing DTI data optimally. DTI is a non-invasive magnetic resonance imaging (MRI) technique for visualizing and quantifying tissue microstructure based on diffusion. The book discusses the theoretical background underlying DTI and advanced techniques based on higher-order models and multi-shell diffusion imaging. It covers the practical implementation of DTI; derivation of information from DTI data; and a range of clinical applications, including neurosurgical planning and the assessment of brain tumors. Its practical utility is enhanced by decision schemes and a fully annotated DTI brain atlas, including color fractional anisotropy maps and 3D tractography reconstructions of major white matter fiber bundles. Featuring contributions from leading specialists in the field of DTI, Diffusion Tensor Imaging: A Practical Handbook is a valuable resource for radiologists, neuroradiologists, MRI technicians and clinicians.

Advances in Data Analysis of Diffusion Tensor Imaging

Advances in Data Analysis of Diffusion Tensor Imaging Book
Author : Cheng Guan Koay
Publisher : Unknown
Release : 2005
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Advances in Data Analysis of Diffusion Tensor Imaging book written by Cheng Guan Koay, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

MRI GOLD Introduction to Brain Research MRI

MRI GOLD Introduction to Brain Research MRI Book
Author : MRI GOLD
Publisher : Lulu.com
Release : 2021-07-26
ISBN : 1326876031
Language : En, Es, Fr & De

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Book Description :

Download MRI GOLD Introduction to Brain Research MRI book written by MRI GOLD, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Introduction to Functional Magnetic Resonance Imaging CD ROM

Introduction to Functional Magnetic Resonance Imaging CD ROM Book
Author : Richard B. Buxton
Publisher : Cambridge University Press
Release : 2002-03-25
ISBN : 9780521002752
Language : En, Es, Fr & De

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Book Description :

An Introduction to Functional Magnetic Resonance Imaging is an invaluable introduction to how fMRI works, from basic principles and underlying physics and physiology, to newer techniques such as arterial spin labeling and diffusion tensor imaging. The supplementary CD-ROM contains all the figures from the book as PowerPoint files, together with movies of cross-sectional anatomical MR images and a library of all the MR images used in the movies as individual Tiff files. As a resource for teachers and researchers, this combination of text and dual platform CD is unsurpassed.

Diffusion MRI

Diffusion MRI Book
Author : Heidi Johansen-Berg,Timothy E. J. Behrens
Publisher : Unknown
Release : 2013-11-26
ISBN : 9780123964601
Language : En, Es, Fr & De

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Book Description :

This title covers the field of diffusion imaging from the fundamental theory to its most cutting-edge applications. It contains sufficient detail to be a reference book for medical physicists, but also covers aspects of experimental design and example applications that will be of interest to clinical and basic neuroscientists. (Neuroscience)

In Vivo Quantification of Cardiac Microstructure with Convex Optimized Diffusion Weighted MRI

In Vivo Quantification of Cardiac Microstructure with Convex Optimized Diffusion Weighted MRI Book
Author : Eric Aliotta
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Diffusion weighted imaging (DWI) is a powerful quantitative magnetic resonance imaging (MRI) technique that can probe tissues in vivo at the microscopic level and provide insight into cellular microstructural environment. Cardiac DWI has great potential value in its ability to answer open questions regarding myocardial structure, dynamics, and remodeling. Unfortunately, several technical limitations of current DWI techniques make its application in the beating heart very challenging, which leads to erroneous or inconsistent results. Amongst the challenges are an extreme sensitivity to bulk physiological motion, low signal to noise ratios (SNR), long scan times, and geometric image distortions. In this dissertation, these limitations are addressed with novel technical developments applied to the DWI pulse sequence including convex optimized diffusion gradient waveform design and multi-parametric tissue characterization. A brief introduction to Nuclear Magnetic Resonance (NMR) and MRI is provided in Chapter 1. This leads into a description of the fundamental components of a DWI acquisition in Chapter 2 and an overview of the current state of cardiac DWI in Chapter 3. In Chapter 4, a novel DWI strategy called Convex Optimized Diffusion Encoding (CODE) is described. CODE is a mathematical framework that formulates diffusion encoding gradient design as a convex optimization problem and automatically generates motion compensated (MOCO) waveforms that achieve the shortest possible echo times (TE) and thus improve SNR. First and second order moment nulled CODE (CODE-M1M2) permits DWI that is robust to cardiac motion with higher SNR than an existing MOCO technique. First order motion compensated CODE-M1 also improves robustness to cardiac induced motion in liver DWI with higher SNR than M1 nulled bipolar DWI. CODE can also be used for non-motion compensated DWI and improves SNR compared with traditional monopolar DWI in the brain. In Chapter 5 we present a multi-parametric DWI strategy that simultaneously yields maps of the apparent diffusion coefficient (ADC) and T2 relaxation time constant in the heart (T2+ADC). Typically, DWI protocols include multiple acquisitions with a range of diffusion encoding strengths (b-value), but with constant TE to isolate the effect of diffusion of the signal. The joint T2+ADC approach varies both b-value and TE within the acquisition to facilitate estimation of both ADC and T2 relaxation. T2+ADC permits joint reconstruction with no increase in scan time compared with DWI alone and no effect on ADC measurement. In Chapter 6 we use CODE-M1M2 diffusion encoding to perform cardiac diffusion tensor imaging (cDTI) and generate maps of myocardial microstructure in healthy volunteers. cDTI can be used to map myocardial fiber and myolaminar sheetlet orientations, which can contribute to our understanding of ventricular microstructure in health and disease and facilitate sophisticated mechanical models of cardiac dynamics. However, it is important to understand the uncertainty underlying these measurements to inform interpretation and define acquisition limitations. We apply a previously described bootstrap technique to measure the uncertainty in the diffusion tensors derived from CODE-M1M2 cDTI and establish achievable levels of precision in clinically feasible scan times. In Chapter 7 the CODE framework is extended to compensate for the effect of eddy currents, which are a common cause of image distortions in DWI and DTI. Diffusion encoding gradients must be very strong to encode microscopic molecular displacements and these strong gradient pulses induce unwanted eddy currents in conductive MRI hardware components. If not addressed, eddy currents lead to distorted images and corrupted diffusion parameter estimates. We incorporate an eddy current model into the CODE optimization framework to develop eddy current nulled CODE (EN-CODE). EN-CODE accomplishes eddy current nulling with TEs that are comparable to traditional monopolar encoding and much shorter than the established twice refocused spin echo (TRSE) technique for eddy current nulling. The developments described in this dissertation represent an improvement in the flexibility, efficiency, and robustness of diffusion encoding. The CODE framework can also be easily modified to address additional constraints and thus may prove useful in currently unforeseen applications.

Translational Dynamics and Magnetic Resonance

Translational Dynamics and Magnetic Resonance Book
Author : Paul T. Callaghan
Publisher : OUP Oxford
Release : 2011-09-15
ISBN : 0191621048
Language : En, Es, Fr & De

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Book Description :

Taking the reader through the underlying principles of molecular translational dynamics, this book outlines the ways in which magnetic resonance, through the use of magnetic field gradients, can reveal those dynamics. The measurement of diffusion and flow, over different length and time scales, provides unique insight regarding fluid interactions with porous materials, as well as molecular organisation in soft matter and complex fluids. The book covers both time and frequency domain methodologies, as well as advances in scattering and diffraction methods, multidimensional exchange and correlation experiments and orientational correlation methods ideal for studying anisotropic environments. At the heart of these new methods resides the ubiquitous spin echo, a phenomenon whose discovery underpins nearly every major development in magnetic resonance methodology. Measuring molecular translational motion does not require high spectral resolution and so finds application in new NMR technologies concerned with 'outside the laboratory' applications, in geophysics and petroleum physics, in horticulture, in food technology, in security screening, and in environmental monitoring.

Magnetic Resonance Brain Imaging

Magnetic Resonance Brain Imaging Book
Author : Jörg Polzehl,Karsten Tabelow
Publisher : Springer Nature
Release : 2019-09-25
ISBN : 3030291847
Language : En, Es, Fr & De

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Book Description :

This book discusses the modeling and analysis of magnetic resonance imaging (MRI) data acquired from the human brain. The data processing pipelines described rely on R. The book is intended for readers from two communities: Statisticians who are interested in neuroimaging and looking for an introduction to the acquired data and typical scientific problems in the field; and neuroimaging students wanting to learn about the statistical modeling and analysis of MRI data. Offering a practical introduction to the field, the book focuses on those problems in data analysis for which implementations within R are available. It also includes fully worked examples and as such serves as a tutorial on MRI analysis with R, from which the readers can derive their own data processing scripts. The book starts with a short introduction to MRI and then examines the process of reading and writing common neuroimaging data formats to and from the R session. The main chapters cover three common MR imaging modalities and their data modeling and analysis problems: functional MRI, diffusion MRI, and Multi-Parameter Mapping. The book concludes with extended appendices providing details of the non-parametric statistics used and the resources for R and MRI data.The book also addresses the issues of reproducibility and topics like data organization and description, as well as open data and open science. It relies solely on a dynamic report generation with knitr and uses neuroimaging data publicly available in data repositories. The PDF was created executing the R code in the chunks and then running LaTeX, which means that almost all figures, numbers, and results were generated while producing the PDF from the sources.

MRI Atlas of Human White Matter

MRI Atlas of Human White Matter Book
Author : Susumu Mori
Publisher : Elsevier Science Limited
Release : 2005
ISBN : 9780444517418
Language : En, Es, Fr & De

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Book Description :

A unique new MRI modality, called diffusion tensor imaging (DTI) allows the three-dimensional study of the large white matter (WM) fiber bundles at macroscopic resolution (millimeter scale). This book provides a three-dimensional and two-dimensional in vivo atlas of various white matter tracts in the human brain. The images are based on diffusion tensor imaging and various tracts are reconstructed three-dimensionally from the data. Following an introduction and description of the methodology (Chapters 1 and 2), the 3D anatomy of individual tracts is delineated in Chapter 3. Chapter 4 consists of a series of color-coded orientation maps to delineate white matter anatomy in a slice-by-slice manner, in which the structures are extensively annotated.

Geometric and Variational Methods for Diffusion Tensor MRI Processing

Geometric and Variational Methods for Diffusion Tensor MRI Processing Book
Author : Christophe Lenglet
Publisher : Unknown
Release : 2006
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This thesis deals with the development of new processing tools for Diffusion Tensor Magnetic Resonance Imaging (DT-MRI). This recent MRI technique is of utmost importance to acquire a better understanding of the brain mechanisms and to improve the diagnosis of neurological disorders. We introduce new algorithms relying on Riemannian geometry, partial differential equations and front propagation techniques. The first part of this work is theoretical. After a few reminders about the human nervous system, MRI and differential geometry, we study the space of multivariate normal distributions. The introduction of a Riemannian structure on that space allows us to define statistics and intrinsic numerical schemes that will constitute the core of the algorithms proposed in the second part. The properties of that space are important for DT-MRI since diffusion tensors are the covariance matrices of normal laws modeling the diffusion of water molecules at each voxel of the acquired volume. The second part of this thesis is methodological. We start with the introduction of original approaches for the estimation and regularization of DT-MRI. We then show how to evaluate the degree of connectivity between cortical areas. Next, we introduce a statistical surface evolution framework for the segmentation of those images. Finally, we propose a non-rigid registration method. The last part of this thesis is dedicated to the application of our tools to two important neuroscience problems: the analysis of the connections between the cerebral cortex and the basal ganglia, implicated in motor tasks, and the study of the anatomo-functional network of the human visual cortex.

Annual Reports on NMR Spectroscopy

Annual Reports on NMR Spectroscopy Book
Author : Graham A. Webb
Publisher : Academic Press
Release : 2013-06-07
ISBN : 0124079059
Language : En, Es, Fr & De

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Book Description :

NMR is an analytical tool used by chemists and physicists to study the structure and dynamics of molecules. In recent years, no other technique has gained such significance as NMR spectroscopy. It is used in all branches of science in which precise structural determination is required and in which the nature of interactions and reactions in solution is being studied. Annual Reports on NMR Spectroscopy has established itself as a premier means for the specialist and non-specialist alike to become familiar with new techniques and applications of NMR spectroscopy. Nuclear magnetic resonance (NMR) is an analytical tool used by chemists and physicists to study the structure and dynamics of molecules In recent years, no other technique has gained such significance as NMR spectroscopy. It is used in all branches of science in which precise structural determination is required and in which the nature of interactions and reactions in solution is being studied Annual Reports on NMR Spectroscopy has established itself as a premier means for the specialist and non-specialist alike to become familiar with new techniques and applications of NMR spectroscopy

Parallel Imaging in Clinical MR Applications

Parallel Imaging in Clinical MR Applications Book
Author : Stefan O. Schönberg,Olaf Dietrich,Maximilian F Reiser
Publisher : Springer Science & Business Media
Release : 2007-01-11
ISBN : 354068879X
Language : En, Es, Fr & De

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Book Description :

This book presents the first in-depth introduction to parallel imaging techniques and, in particular, to the application of parallel imaging in clinical MRI. It will provide readers with a broader understanding of the fundamental principles of parallel imaging and of the advantages and disadvantages of specific MR protocols in clinical applications in all parts of the body at 1.5 and 3 Tesla.