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Innovative Approaches In Drug Discovery

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Innovative Approaches in Drug Discovery

Innovative Approaches in Drug Discovery Book
Author : Bhushan Patwardhan,Rathnam Chaguturu
Publisher : Academic Press
Release : 2016-10-03
ISBN : 0128018224
Language : En, Es, Fr & De

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Book Description :

Despite considerable technological advances, the pharmaceutical industry is experiencing a severe innovation deficit, especially in the discovery of new drugs. Innovative Approaches in Drug Discovery: Ethnopharmacology, Systems Biology and Holistic Targeting provides a critical review and analysis of health, disease and medicine, and explores possible reasons behind the present crisis in drug discovery. The authors illustrate the benefits of systems biology and pharmacogenomics approaches, and advocate the expansion from disease-centric discovery to person-centric therapeutics involving holistic, multi-target, whole systems approaches. This book lays a path for reigniting pharmaceutical innovation through a disciplined reemergence of pharmacognosy, embracing open innovation models and collaborative, trusted public-private partnerships. With unprecedented advances made in the development of biomedically-relevant tools and technologies, the need is great and the time is now for a renewed commitment towards expanding the repertoire of medicines. By incorporating real-life examples and state-of-the-art reviews, this book provides valuable insights into the discovery and development strategies for professionals, academicians, and students in the pharmaceutical sciences. Analyzes the reasons behind historical drug failures to provide valuable insights on lessons learned Uses current scientific research to promote learning from traditional knowledge systems and through the integration of traditional and western medicines Discusses advances in technologies and systems biology to support the transition from formulation discovery to therapeutic discovery

Innovative Approaches in Drug Research

Innovative Approaches in Drug Research Book
Author : A. F. Harms
Publisher : Elsevier Publishing Company
Release : 1986
ISBN : 9780444426062
Language : En, Es, Fr & De

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Book Description :

Download Innovative Approaches in Drug Research book written by A. F. Harms, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Molecular Modeling with the Aim Innovative Approaches for Drug Design

Molecular Modeling with the Aim  Innovative Approaches for Drug Design Book
Author : Dusanka Janezic
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

We have developed new computational tools at the molecular scale for protein-ligand binding in drug discovery, ProBiS Tools (algorithm, database, and web servers) for predicting and modeling of medically interesting proteins based on graph theoretical approaches, combined with molecular simulations based on our earlier developed fast maximum clique algorithm, for finding a maximum clique in an undirected graph that is up to 100 times faster than the best comparable algorithm. ProBiS Tools opens a whole new range of possibilities in drug discovery. Our newly developed approach is particularly useful in the context of precision medicine. Precision medicine promises more effective and safer treatments with lesser side effects. It depends on the advances within genomics, proteomics and transcriptomics fields that generate extensive amounts of data as well as it depends on the advances of computational biology. Our aim is extensive integration of the genomic, proteomic, and system level information (Figure 1) that enable evaluation of drug's effects on each and every person individually based on his/her genetic make-up. Our tools enable joining several otherwise disconnected areas of research, i.e., genome sequence studies, protein structures, and MD simulations.

Innovations and Implementations of Computer Aided Drug Discovery Strategies in Rational Drug Design

Innovations and Implementations of Computer Aided Drug Discovery Strategies in Rational Drug Design Book
Author : Sanjeev Kumar Singh
Publisher : Springer Nature
Release : 2021-05-10
ISBN : 9811589364
Language : En, Es, Fr & De

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Book Description :

Download Innovations and Implementations of Computer Aided Drug Discovery Strategies in Rational Drug Design book written by Sanjeev Kumar Singh, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Antiepileptic Drug Discovery

Antiepileptic Drug Discovery Book
Author : Alan Talevi,Luisa Rocha
Publisher : Humana Press
Release : 2016-09-24
ISBN : 9781493963539
Language : En, Es, Fr & De

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Book Description :

This thorough volume delves into antiepileptic drug discovery with a comprehensive collection of innovative approaches for the development of antiepileptic therapies, focusing on novel molecular targets for antiepileptic drugs, computer-aided approaches for the identification of new drug candidates, and therapeutic strategies to overcome refractory epilepsy. The last section illustrates the potential benefits that network pharmacology and rational drug repurposing could bring to the antiepileptic drug discovery community. Written for the Methods in Pharmacology and Toxicology series, chapters include the kind of detailed description and implementation advice to ensure results in the laboratory. Authoritative and practical, Antiepileptic Drug Discovery: Novel Approaches aims to provide medicinal chemists, pharmacologists, and other researchers with the tools need to further explore the study of pharmacoresistant epilepsy and the discovery of new antiepileptic drugs.

Applications of Pharmacokinetic Principles in Drug Development

Applications of Pharmacokinetic Principles in Drug Development Book
Author : Rajesh Krishna
Publisher : Springer Science & Business Media
Release : 2004
ISBN : 9780306477669
Language : En, Es, Fr & De

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Book Description :

This book presents a collection of articles that represent individual and expert perspectives in both preclinical and clinical development, including case studies on real-life examples of successful drugs that add value to the pharmacokinetic principles learned and applied. Unlike existing books that focus on pharmacokinetic theory, the current book emphasizes application of pharmacokinetic principles in new drug development.

Drug Design Strategies

Drug Design Strategies Book
Author : David J. Livingstone,Andrew M. Davis
Publisher : Royal Society of Chemistry
Release : 2011-11
ISBN : 1849731667
Language : En, Es, Fr & De

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Book Description :

Shows how different parts of the drug discovery process have developed, with particular emphasis on quantitative aspects and possible future progress.

Drug Discovery and Development Present and Future

Drug Discovery and Development   Present and Future Book
Author : Anonim
Publisher : Unknown
Release : 2011
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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Drug Design and Discovery in Alzheimer s Disease

Drug Design and Discovery in Alzheimer   s Disease Book
Author : Atta-ur-Rahman,Muhammad Iqbal Choudhary
Publisher : Elsevier
Release : 2015-06-27
ISBN : 0128039604
Language : En, Es, Fr & De

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Book Description :

Drug Design and Discovery in Alzheimer’s Disease includes expert reviews of recent developments in Alzheimer's disease (AD) and neurodegenerative disease research. Originally published by Bentham as Frontiers in Drug Design and Discovery, Volume 6and now distributed by Elsevier, this compilation of the sixteen articles, written by leading global researchers, focuses on key developments in the understanding of the disease at molecular levels, identification and validation of molecular targets, as well as innovative approaches towards drug discovery, development, and delivery. Beginning with an overview of AD pharmacotherapy and existing blockbuster drugs, the reviews cover the potential of both natural and synthetic small molecules; the role of cholinesterases in the on-set and progression of AD and their inhibition; the role of beta-site APP clearing enzyme-1 (BACE-1) in the production of ß-amyloid proteins, one of the key reasons of the progression of AD; and other targets identified for AD drug discovery. Edited and written by leading experts in Alzheimer’s disease (AD) and other neurodegenerative disease drug development Describes existing drugs for AD and current molecular understanding of the condition Reviews recent advances in the field, including coverage of cholinesterases, BACE-1, and other drug development targets

Innovative Methods for Rare Disease Drug Development

Innovative Methods for Rare Disease Drug Development Book
Author : Shein-Chung Chow
Publisher : CRC Press
Release : 2020-11-12
ISBN : 1000208214
Language : En, Es, Fr & De

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Book Description :

In the United States, a rare disease is defined by the Orphan Drug Act as a disorder or condition that affects fewer than 200,000 persons. For the approval of "orphan" drug products for rare diseases, the traditional approach of power analysis for sample size calculation is not feasible because there are only limited number of subjects available for clinical trials. In this case, innovative approaches are needed for providing substantial evidence meeting the same standards for statistical assurance as drugs used to treat common conditions. Innovative Methods for Rare Disease Drug Development focuses on biostatistical applications in terms of design and analysis in pharmaceutical research and development from both regulatory and scientific (statistical) perspectives. Key Features: Reviews critical issues (e.g., endpoint/margin selection, sample size requirements, and complex innovative design). Provides better understanding of statistical concepts and methods which may be used in regulatory review and approval. Clarifies controversial statistical issues in regulatory review and approval accurately and reliably. Makes recommendations to evaluate rare diseases regulatory submissions. Proposes innovative study designs and statistical methods for rare diseases drug development, including n-of-1 trial design, adaptive trial design, and master protocols like platform trials. Provides insight regarding current regulatory guidance on rare diseases drug development like gene therapy.

Drug Discovery Targeting Drug Resistant Bacteria

Drug Discovery Targeting Drug Resistant Bacteria Book
Author : Prashant Kesharwani,Sidharth Chopra,Arunava Dasgupta
Publisher : Academic Press
Release : 2020-05-15
ISBN : 0128184817
Language : En, Es, Fr & De

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Book Description :

Drug Discovery Targeting Drug-Resistant Bacteria explores the status and possible future of developments in fighting drug-resistant bacteria. The book covers the majority of microbial diseases and the drugs targeting them. In addition, it discusses the potential targeting strategies and innovative approaches to address drug resistance. It brings together academic and industrial experts working on discovering and developing drugs targeting drug-resistant (DR) bacterial pathogens. New drugs active against drug-resistant pathogens are discussed, along with new strategies being used to discover molecules acting via new modes of action. In addition, alternative therapies such as peptides and phages are included. Pharmaceutical scientists, microbiologists, medical professionals, pathologists, researchers in the field of drug discovery, infectious diseases and microbial drug discovery both in academia and in industrial settings will find this book helpful. Written by scientists with extensive industrial experience in drug discovery Provides a balanced view of the field, including its challenges and future directions Includes a special chapter on the identification and development of drugs against pathogens which exhibit the potential to be used as weapons of war

The Effectiveness of Innovative Approaches in the Treatment of Drug Abuse

The Effectiveness of Innovative Approaches in the Treatment of Drug Abuse Book
Author : Frank M. Tims,James A. Inciardi,Bennett W. Fletcher,Arthur MacNeill Horton, Jr.
Publisher : Praeger
Release : 1997
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

A continuation of the study researched in their previous volumes, this new book looks at the effectiveness of various treatment approaches. These essays represent an effort to systematically integrate science and practice in order to improve drug abuse treatment.

Phenotypic screening in the 21st century

Phenotypic screening in the 21st century Book
Author : Gul Erdemli,Birgit T Priest
Publisher : Frontiers Media SA
Release : 2015-04-21
ISBN : 2889194698
Language : En, Es, Fr & De

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Book Description :

In the genomic era of 1990s-2000s, pharmaceutical research moved to target-based drug discovery which enabled development of a number of small molecule drugs against a wide range of diseases. In many cases however, drugs that arose from genomics failed, questioning the validity of the targets and the suitability of target-based drug discovery as an optimal strategy for all disease states. For monogenic diseases, target-based approaches may be well-suited to the identification of novel therapies. Most diseases, however, are caused by a combination of several genetic and environmental factors and are likely to require simultaneous modulation of multiple molecular targets/pathways for successful treatment. For such diseases, reductionist approaches focusing on individual targets rather than biological networks are unlikely to succeed and new drug development strategies are required. In search of more successful approaches, the pharmaceutical industry is moving towards phenotypic screening beyond individual genes/targets. However, this requires rethinking of diseases and drug discovery approaches from a network and systems biology perspective. Since returning to the pre-genomics era of screening drug candidates in laborious animal models is not a feasible solution, the industry needs to evolve a new paradigm of phenotypic drug discovery within the context of systems biology. Such a paradigm must combine physiologically and disease relevant biological substrates with sufficient throughput, operational simplicity and statistical vigour. Biomarker strategies for translational medicine, as well as preclinical safety and selectivity assessments, would also need to be revised to adapt to the target agnostic style. This focused issue aims to discuss strategies, key concepts and technologies related to systems-based approaches in drug development. Design and implementation of innovative biological assays, featuring multiple target strategies, and rational drug design in the absence of target knowledge during the early drug discovery are illustrated with examples. Specific topics include: • The need for systems-based approaches in drug development • Phenotypic screening strategies • Compound libraries (natural product inspired compound collections) • Target deconvolution and identification • Target agnostic lead discovery and optimization • Multi-target approaches and decoding the phenotype (understanding biological interactions and multiscale systems modelling) • Translational aspects • Early evaluation of selectivity and safety in a target agnostic manner

Drug Discovery

Drug Discovery Book
Author : Robert A. Maxwell,Shohreh B. Eckhardt
Publisher : Springer Science & Business Media
Release : 1990-10-02
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

In their novel approach to Drug Discovery, Maxwell and Eckhardt explore their thesis that the discovery of new drugs-especially of innovative therapeutic agents-is an independent dynamic process that demands the full attention of researchers, rather than a spontaneous consequence of investigative research. Faced with a dearth of quantitative information on how and where innovative drugs were discovered, the authors have developed considerable quantitative data about this process in order to provide a deeper understanding of its true nature.Drug Discovery: A Casebook and Analysis offers a unique quantitative survey of research since World War II that led to the development of 32 innovative therapeutic agents. Factual and concise, each chapter presents a review of the original scientific contributions associated with the discovery of a specific drug. These chapters are followed by a computer analysis of important variables and finally by an interpretation. Drug categories discussed include: • cardiovascular and renal (including renal transplantation) • psychiatric • neurological • rheumatological • anesthesiological • pulmonary • gastrointestinal.Everyone interested in the basic or clinical research leading to important drugs-and the institutional interplay inherent in the process-will find Drug Discovery: A Casebook and Analysis a comprehensive, invaluable reference compendium!

Innovative Dosage Forms

Innovative Dosage Forms Book
Author : Yogeshwar Bachhav
Publisher : John Wiley & Sons
Release : 2019-08-09
ISBN : 3527812202
Language : En, Es, Fr & De

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Book Description :

Teaches future and current drug developers the latest innovations in drug formulation design and optimization This highly accessible, practice-oriented book examines current approaches in the development of drug formulations for preclinical and clinical studies, including the use of functional excipients to enhance solubility and stability. It covers oral, intravenous, topical, and parenteral administration routes. The book also discusses safety aspects of drugs and excipients, as well as regulatory issues relevant to formulation. Innovative Dosage Forms: Design and Development at Early Stage starts with a look at the impact of the polymorphic form of drugs on the preformulation and formulation development. It then offers readers reliable strategies for the formulation development of poorly soluble drugs. The book also studies the role of reactive impurities from the excipients on the formulation shelf life; preclinical formulation assessment of new chemical entities; and regulatory aspects for formulation design. Other chapters cover innovative formulations for special indications, including oncology injectables, delayed release and depot formulations; accessing pharmacokinetics of various dosage forms; physical characterization techniques to assess amorphous nature; novel formulations for protein oral dosage; and more. -Provides information that is essential for the drug development effort -Presents the latest advances in the field and describes in detail innovative formulations, such as nanosuspensions, micelles, and cocrystals -Describes current approaches in early pre-formulation to achieve the best in vivo results -Addresses regulatory and safety aspects, which are key considerations for pharmaceutical companies -Includes case studies from recent drug development programs to illustrate the practical challenges of preformulation design Innovative Dosage Forms: Design and Development at Early Stage provides valuable benefits to interdisciplinary drug discovery teams working in industry and academia and will appeal to medicinal chemists, pharmaceutical chemists, and pharmacologists.

Resolution Pharmacology Innovative Therapeutic Approaches Based on the Biology of Resolution to Control Chronic Diseases of Western Societies

Resolution Pharmacology   Innovative Therapeutic Approaches Based on the Biology of Resolution to Control Chronic Diseases of Western Societies Book
Author : Mauro Perretti,Trinidad Montero-Melendez,Lucy V. Norling
Publisher : Frontiers Media SA
Release : 2019-11-04
ISBN : 2889630846
Language : En, Es, Fr & De

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Book Description :

In this eBook, we have grouped together 16 original contributions which have addressed the translational potential for therapeutics developed on the conceptual framework of the resolution of inflammation. The take home message of our effort, and the efforts of our colleagues who wrote these pieces, is that completely different drugs can be designed and modelled on the mediators and targets of resolution. By implementing this 180° shift in the way we plan the drug development programme (that is by focusing on agonists and/or promoting the actions of pro-resolution agonists) we can offer a fresh approach to the clinical management of chronic diseases that affect the modern society. With this series of articles we foresee the birth of Resolution Pharmacology. The 16 contributions presented herein confirm the broad relevance of pro-resolving physio-pharmacology with the description of pro-resolving mechanisms in distinct diseases, from atherosclerosis and heart infarct, to cystic fibrosis and diabetes. This testifies on one hand the fundamental role that inflammatory mechanisms play in virtually all pathological settings and, on the other hand, the great potential that a novel approach to anti-inflammatory therapy by exploiting resolution mediators and targets may have. Thus, while there is broad recognition that evidence-based interventions have transformed cardiovascular, inflammation and endocrine care, new therapies are still needed for growing numbers of patients with unmet needs. As an example, an estimated 17 million people world-wide die annually of cardiovascular diseases, particularly heart attacks and strokes. Cardiovascular diseases occur almost equally in men and women and are the leading cause of death and morbidity worldwide. It is estimated that only 1/1,000 compounds entering preclinical testing are then trialled in man and the actual cost of developing a new therapeutic into clinical practice has grown exponentially over the past two decades (estimated $1.2B). Over the last 20 years or more, scientists have appreciated the biology of the resolution of inflammation, which provides a new paradigm in our understanding of the inflammatory process with the appreciation of genetic, molecular and cellular mechanisms that are engaged to actively resolve inflammation. The ‘resolution of acute inflammation’ is enabled by counter-regulatory checkpoints to terminate the host reaction while at the same time promoting healing and repair. The potential of lipid mediators to enact pro-resolving effects in the context of cystic fibrosis is presented by Recchiuti et al., while Fredman reasons on the potential for these molecules in atherosclerosis. This resonates well with the contributions from Bäck and colleagues who have focused on pro-resolving receptors to offer vasculo-protection in intimal hyperplasia and more generally in cardiovascular disease. On the same vein is the scholar contribution of Leoni and Soehnlein who focus on heart disease, with Qin et al. presenting the latest findings on the effect of an Annexin A1-derived peptide in myocardial infarction. Hansen et al. and de Gaetano et al. bring in the complexity of diabetes and associated morbidity with a focus on specialised pro-resolving lipid mediators but also introducing the potential of dietary approaches. As the western diet favours disease, an omega-3 rich diet can lead to higher availability of lipid mediators to afford tissue protection if not reverting its pathological status. Docosahexaenoic acid and its bioactive derivatives are endowed with potent anti-nociceptive properties following bone fracture, as shown by Zhang et al. The broad relevance of the pharmacological approach reaches the skin with Resolvin D1 protecting against UV irradiation (Saito et al.). Reduced skin inflammation is also achieved with an Annexin A1 peptide that impacts on the outcome of heterologous transplantation (Lacerda et al.). Indeed, modulating the phenotype of immune cells can provide long lasting beneficial outcomes, as attained with CDK inhibitors (Cartwright et al.) and PI3K inhibitors in experimental gout (Galvao et al.). Such an effect is also achieved with a third group of pro-resolving therapeutics, the melanocortin receptor agonists, with important modulation of macrophage reactivity (Patruno et al.) with Spana et al., providing new pharmacology following selective activation of the MC1 receptor. Finally, Hopkin et al. discuss the potential for targeting immune cell trafficking as a way to control immune mediated diseases, bringing in not only pro-resolving mediator agonists, but also approaches to reduce chemo/cytokine gradients or modulating S1P and 11-beta hydroxysteroid dehydrogenase. Finally, we wish to highlight that this wealth of science has also bought to the forefront specific pro-resolving receptors (including FPR2/ALX, GPR32, ChemR23 and MC1), all G protein coupled receptors that are therefore amenable to pharmacological exploitation for drug discovery programmes. We see that not only agonists to the receptors can be developed, some of them modelled on the natural ligands (e.g. resolvins, lipoxins, Annexin A1-derived peptides or melanocortin peptides), but also that the creativity of this pharmacology can be attained through biased ligands and positive allosteric modulators. Deep knowledge of pro-resolving receptor biology and their cell-specific signalling can accelerate the generation of novel anti-inflammatory depicted on the resolution of inflammation. In conclusion, with this eBook, we propose time is ready to exploit the concepts of resolution and use its targets and mediators for the identification of better drugs to establish ‘Resolution Pharmacology’. We predict Resolution Pharmacology will represent an important innovation in the way common diseases will be treated in the next decades of this millennium.

Essentials of Medicinal Chemistry

Essentials of Medicinal Chemistry Book
Author : Andrejus Korolkovas
Publisher : Wiley-Interscience
Release : 1988-08-16
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This text/reference presents fundamental aspects of medicinal chemistry and contains comprehensive information on approximately 5,000 drugs currently in use, describing their therapeutic uses, their mechanisms of action, and their main side and harmful effects. Employs the latest World Health Organization (WHO) pharmacological classification and provides extensive information for drugs on WHO's latest list of basic or essential pharmaceuticals, including history: chemical, trade and generic names; chemical structure; obtention; physical and chemical properties; mechanisms of action; therapeutic uses; adverse reactions; biotransformation; chemical and pharmacological incompatibilities; bioavailability; dosage; storage; and assay.

Drug Intelligence Clinical Pharmacy

Drug Intelligence   Clinical Pharmacy Book
Author : Anonim
Publisher : Unknown
Release : 1987
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Drug Intelligence Clinical Pharmacy book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Cognitive Enhancement

Cognitive Enhancement Book
Author : Kathleen M. Kantak,Joseph G. Wettstein
Publisher : Springer
Release : 2015-05-14
ISBN : 3319165224
Language : En, Es, Fr & De

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Book Description :

This book highlights the behavioral and neurobiological issues relevant for drug development, reviews evidence for an innovative approach for drug discovery and presents perspectives on multiple special topics ranging from therapeutic drug use in children, emerging technologies and non-pharmacological approaches to cognitive enhancement.

Journal of Pharmacological Methods

Journal of Pharmacological Methods Book
Author : Anonim
Publisher : Unknown
Release : 1987
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Journal of Pharmacological Methods book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.