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Innate Immunity

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Innate Immunity

Innate Immunity Book
Author : Yves Carton
Publisher : Iste Press - Elsevier
Release : 2019-11-15
ISBN : 1785483080
Language : En, Es, Fr & De

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Book Description :

Innate immunity is a new branch of immunology, confirmed by three Nobel Prize winners in 2011. It is the first line of defense against pathogens and is in a way the preliminary step of adaptive immunity which occurs later, and only present in vertebrates. This book examines the way in which innate immunity was discovered in invertebrates. As a starting point, it looks at the work of Louis Pasteur on silkworm disease and the findings of Ilya Metchnikov, discoverer of phagocytosis. It also investigates André Paillot, who in 1920 demonstrated the existence of humoral immunity in insects, unrelated to the type of immunity that was initially thought to be present in all vertebrates. Finally, Innate Immunity shows how the group directed by Jules Hoffmann found strong similarities between the innate immunity response of insects and mammals. The discovery of a receptor protein in Drosophila, which is also found in humans, was what led to Jules Hoffmann being awarded the Nobel Prize in 2011. Presents the transformations experienced by the domains of innate immunity Shows the lineage of these results Bridges the gap between innate immunity of invertebrates and that of vertebrates

Innate Immunity of Plants Animals and Humans

Innate Immunity of Plants  Animals and Humans Book
Author : Holger Heine
Publisher : Springer Science & Business Media
Release : 2007-12-07
ISBN : 3540739300
Language : En, Es, Fr & De

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Book Description :

This book has been cunningly designed to provide an overview of our current knowledge about the innate immune systems of these three types of organisms. It not only covers the innate immune mechanisms and responses of such diverse organisms as plants, Cnidaria, Drosophila, urochordates and zebrafish, but also the major receptor systems in mammalians and humans. It delves too into the central defense mechanisms, antimicrobial peptides and the complement system.

Innate Immunity Resistance and Disease Promoting Principles

Innate Immunity  Resistance and Disease Promoting Principles Book
Author : G. Hartmann,H. Wagner
Publisher : Karger Medical and Scientific Publishers
Release : 2013-06-05
ISBN : 3318023485
Language : En, Es, Fr & De

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Book Description :

Our understanding of the complex innate immune response is increasing rapidly. Its role in the protection against viral or bacterial pathogens is essential for the survival of an organism. However, it is equally important to avoid unregulated inflammation because innate immune responses can cause or promote chronic autoinflammatory diseases such as gout, atherosclerosis, type 2 diabetes or certain aspects of the metabolic syndrome. In this book leading international experts in the field of innate immunity share their findings, define the ‚state of the art‘ in this field and evaluate how insight into the molecular basis of these diseases could help in the design of new therapies. A tremendous amount of work on the innate immune response has been done over the last fifteen years, culminating in the 2011 Nobel Prize in Physiology/Medicine awarded for the discoveries of Toll genes in immunity in flies, membrane-bound Toll-like receptors in mammals, and dendritic cells as initiators of adaptive immunity.

Non specific Innate Immunity Against Escherichia Coli Infection in White Leghorn Chickens

Non specific Innate Immunity Against Escherichia Coli Infection in White Leghorn Chickens Book
Author : Hsuan-Jen Huang
Publisher : Unknown
Release : 2000
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Leghorns (Poultry), immunology, leghorns (Poultry), diseases, Escherichia coli infections in animals. - This research was initiated to investigate a high mortality problem occurring in market age broiler chickens in Oregon. Initial field investigations revealed that mortality was due to the systemic bacterial infections. The subsequent laboratory experiments suggested that suppressed short-term, non-specific innate immunity rather than pathogenic properties of bacteria caused the systemic bacterial infection. The objectives of research described were to analyze and characterize the type of innate immunity in chickens by developing a model; analyzing this immunity with artificial induction by inactive agents; and demonstrating the involvement of the type of immunity in viral infection. Escherichia coli strain 01:K1 causes systemic infection in chickens after the intra-airsac inoculation. Levels of immunity can be determined by the viable organism count in the internal organs of infected birds. Bacterial counts were significantly lower in the liver or spleen of vaccinated birds at 6, 12 or 24 hrs after inoculation than in controls. An oil-adjuvanted vaccine showed some deterioration in its immunogenicity after prolonged storage or heating at 100 C. Non-specific innate immunity induced by intravenous injection of inactivated bacteria or LPS, or subcutaneous injection of silver nitrate induced significant immunity in 24 hours against infection with E. coli based on viable bacterial counts in the spleen. Nonspecific immunity induced by formalin-inactivated Staphylococcus aureus cell suspension (FSA) was comparable to specific immunity induced by a specific vaccine as determined by cumulative mortality during 7 days and the viable bacterial count in the spleen after infection. This nonspecific immunity appeared as early as 6 hours and lasted for less than 72 hours after stimulation. Birds vaccinated with NDV vaccines induced significant protection against challenge exposure with 01:K1 strain for a period of 2-8 days post vaccination. Secondary NDV vaccination administered 14 days later failed to induce immunity against E. coli when infected 1 or 5 days after the vaccination. Treatment with cold stress or corticosterone suppressed the induction of nonspecific immunity by FSA or NDV vaccination. These results indicate that nonspecific innate immunity against E. coli in chickens can be induced by injection of killed bacteria or primary NDV vaccination.

Innate Immunity

Innate Immunity Book
Author : Jonathan Ewbank,Eric Vivier
Publisher : Springer Science & Business Media
Release : 2008
ISBN : 1588297462
Language : En, Es, Fr & De

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Book Description :

Immunologists today are interested in all of the diverse cell-types involved in host defense and have a deeper appreciation of the importance of innate immune mechanisms as a first line of protection against pathogens. This volume thus discusses the isolation and functional characterization of cells involved in innate immunity in mouse and man, including mast cells and eosinophils. Other focuses include natural killer cells, methods in statistics, in vivo imaging, genome engineering, and mutagenesis and culture that are adapted to the study of innate immunity in these hosts. These are complemented with a series of chapters dealing with alternative models: plants, worms, mosquitoes, flies, and fish. Together, these approaches and models are being used to dissect the complex interplay between hosts and pathogens and contribute to developing strategies to help fight infection. With chapters written by experts on the cutting-edge of this technology, Innate Immunity is an essential reference for immunologists, histologists, geneticists, and molecular biologists.

The Role of Interferon Regulatory Factor 3 in Innate Immunity

The Role of Interferon Regulatory Factor 3 in Innate Immunity Book
Author : Lorena Navarro
Publisher : Unknown
Release : 2002
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download The Role of Interferon Regulatory Factor 3 in Innate Immunity book written by Lorena Navarro, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Innate Immunity in Arabidopsis Thaliana

Innate Immunity in Arabidopsis Thaliana Book
Author : William Robert Underwood
Publisher : Unknown
Release : 2006
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Innate Immunity in Arabidopsis Thaliana book written by William Robert Underwood, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The Role and Molecular Mechanism of Interleukin 17A in Innate Immunity and Allergic Response in Human Airway Epithelium

The Role and Molecular Mechanism of Interleukin 17A in Innate Immunity and Allergic Response in Human Airway Epithelium Book
Author : Fei Huang
Publisher : Unknown
Release : 2007
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download The Role and Molecular Mechanism of Interleukin 17A in Innate Immunity and Allergic Response in Human Airway Epithelium book written by Fei Huang, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The Innate Immune System

The Innate Immune System Book
Author : Masaru Taniguchi,S. Akira,Toshinori Nakayama
Publisher : Elsevier Science Health Science Division
Release : 2005
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The Uehara Memorial Foundation Symposium 2005, entitled "The Innate Immune System: Strategies for Disease Control," was convened in Tokyo from July 11th to July 13th, 2005. The aim of the symposium was to bring together leading scientists in the field from all over the world, and to discuss the latest research findings on molecular events in the innate immune system, the interface between innate and acquired immunity, and potential applications of recent findings. It was an explicit aim of this symposium to increase our understanding in this field and further the development of novel strategies for disease control in the 21st century.--Preface.

The Human Body Concepts of Anatomy and Physiology

The Human Body  Concepts of Anatomy and Physiology Book
Author : Bruce Wingerd,Patty Bostwick Taylor
Publisher : Jones & Bartlett Publishers
Release : 2020-04-20
ISBN : 128421799X
Language : En, Es, Fr & De

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Book Description :

The new edition of Bruce Wingerd's The Human Body: Concepts of Anatomy and Physiology helps encourage learning through concept building, and is truly written with the student in mind. Learning Concepts divide each chapter into easily absorbed subunits of information, making learning more achievable. Since students in a one-semester course may have little experience with biological and chemical concepts, giving them tools such as "concept statements," "concept check" questions, and a "concept block study sheet" at the end of each chapter help them relate complex ideas to simple everyday events. The book also has a companion Student Notebook and Study Guide (available separately) that reinvents the traditional study guide by giving students a tool to help grasp information in class and then reinforce learning outside of class. With additional, powerful options like the ADAM Interactive Anatomy Online Student Lab Activity Guide, students have access to learning activities to help them study, understand, and retain critical course information.

Innate Immune System of Skin and Oral Mucosa

Innate Immune System of Skin and Oral Mucosa Book
Author : Nava Dayan,Philip W. Wertz
Publisher : John Wiley & Sons
Release : 2011-08-23
ISBN : 0470437774
Language : En, Es, Fr & De

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Book Description :

An in-depth look at cutting-edge research on the body's innate immune system Innate immunity is the body's first line of protection against potential microbial, viral, and environmental attacks, and the skin and oral mucosa are two of the most powerful barriers that which we rely on to stay well. The definitive book on the subject, Innate Immune System of Skin and Oral Mucosa: Properties and Impact in Pharmaceutics, Cosmetics, and Personal Care Products provides a comprehensive overview of these systems, including coverage of antimicrobial peptides and lipids and microbial challenges and stressors that can influence innate immunity. Designed to help experts and newcomers alike in fields like dermatology, oral pathology, cosmetics, personal care, and pharmaceuticals, the book is filled with suggestions to assist research and development. Looking at the many challenges facing the innate immune system, including the impact of topically applied skin products and medications, Innate Immune System of Skin and Oral Mucosa paves the way for next generation treatment avenues, preventative approaches, and drug development.

Trends in Innate Immunity

Trends in Innate Immunity Book
Author : Arne Egesten,Axel Schmidt,Heiko Herwald
Publisher : Karger Medical and Scientific Publishers
Release : 2008
ISBN : 3805585489
Language : En, Es, Fr & De

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Book Description :

The last decade has witnessed the delineation of innate immunity - a new area which has revolutionized our understanding of host-parasite interactions and their impact on defense mechanisms in infectious and noninfectious diseases. This volume of the book series 'Contributions to Microbiology' provides an update of the current knowledge of this expanding field of research and highlights some of its most important aspects. In eleven state-of-the-art articles, eminent international experts in the field address topics such as the innate immune system in mammals and insects, microbial protein ligands, antimicrobial peptides, complement, antibacterial chemokines, the role of neutrophils and monocytes, oxidative innate immune defenses and the effect of aging on innate immunity. The book will be a valuable resource for microbiologists, immunologists, students, scientists of other related disciplines, and clinicians with an interest in infectious or immunological diseases.

Target Pattern Recognition in Innate Immunity

Target Pattern Recognition in Innate Immunity Book
Author : Uday Kishore
Publisher : Springer Science & Business Media
Release : 2010-01-01
ISBN : 9781441909015
Language : En, Es, Fr & De

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Book Description :

Target pattern recognition in innate immunity is responsible for the immediate, usually protective, responses shown against invading microorganisms, and it is the principal feature of self and non-self recognition by virtue of the recognition of structures on the microbial pathogens, which are not found on host cells. This is an area that has been very actively researched, over approximately the past 12 years, and therefore this volume provides a timely comprehensive, and up to date, summary of the types and range of cell surface, intracellular, and secreted, host proteins involved in the recognition of microbial products, and of the protective mechanisms triggered as a result of the recognition events. The Toll-like receptors, first described in Drosophila and now well-characterised on human cells, provide an excellent demonstration of the wide range of different microbial products recognised by this family of receptors and of the signalling pathways which are triggered thus leading to induction of inflammatory cytokines and the activation of genes producing antimicrobial products. In addition, several cell surface proteins involved in target pattern recognition have been described on the surfaces of macrophages (macrophage mannose receptor and macrophage scavenger receptors), and on dendritic cells (DEC205), and to be involved with the uptake and clearance of whole microorganisms and polyanioic ligands. Pattern recognition is also utilised by intracellular receptors, with NOD-like receptors in the cytosol recognizing microbial molecules and activating the production of inflammatory cytokines or pathways that induce the production of inflammatory molecules. Secreted proteins, such as the pentraxins, which includes the acute phase reacting, C-reactive protein (CRP) and serum amyloid protein (SAP), and the collectins (mannan binding lectin, lung surfactant protein A and D) and ficolins can also readily recruit killing and clearance systems. Indeed, the serum complement system, which is one of the major defence systems in the bloodstream, is efficiently activated by CR P on its binding to the phosphocholine groups of microbial phospholipids—and the subsequent interaction of the bound CR P with C1q—to give classical pathway activation, or MBL, or ficolin, binding to arrays of mannose or N-acetyl-glucosamine residues, respectively, on the surfaces of microorganisms—to give lectin pathway activation. Also, in addition to the activation and clearance events associated with complement activation by some of the secreted pattern recognition receptors, it is accepted that all these pattern recognition receptors can generally accelerate the uptake and clearance of microbes via phagocytic cells. In view of the growing interest in the cross-talk between innate and adaptive immunity, a thorough understanding of the initial recognition and triggering events, mediated via innate immune receptors, as addressed in this volume, is clearly very useful in helping to also fully understand the mechanisms of activation and control of the adaptive immune system—and to allow a full assessment of the relative roles played by innate immunity and adaptive immunity against a particular infection in higher organisms.

Innate Immunity and the Eye

Innate Immunity and the Eye Book
Author : Manfred Zierhut,Friedrich Paulsen,Jerry Y Niederkorn
Publisher : JP Medical Ltd
Release : 2013-04-30
ISBN : 9350903091
Language : En, Es, Fr & De

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Book Description :

The innate immune system comprises the cells and mechanisms that are the first line of defence against infection by other organisms. This book provides a comprehensive synopsis of eye diseases, their immunological mechanisms and the role of the immune cells and mediators. Beginning with an introduction to the role of the innate immune system, the following chapters discuss the different types of immune cells in the eye and their role in the etiopathogenesis of various diseases including glaucoma and age-related macular degeneration. Edited by Manfred Zierhut, recognised expert from the University of Tuebingen Germany, this book is presented in an easy to read format, enabling practitioners to understand even the most sophisticated eye disorders from an immunological perspective. Key points Comprehensive synopsis of the role of the innate immune system in eye diseases Covers different types of immune cells Edited by internationally recognised specialist in Germany

Experimental Approaches For The Investigation Of Innate Immunity The Human Innate Immunity Handbook

Experimental Approaches For The Investigation Of Innate Immunity  The Human Innate Immunity Handbook Book
Author : Richard Bucala,Ruth R Montgomery
Publisher : World Scientific
Release : 2016-01-15
ISBN : 9814678740
Language : En, Es, Fr & De

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Book Description :

The recent explosion of information in innate immune pathways for recognition, effect or responses, and genetic regulation has given impetus to investigations into analogous pathways in the human immune response, which in turn has produced attendant insights into both normal physiology and immunopathology. This volume presents a compendium of methods and protocols for the investigation of human innate immunity with application to the study of normal immune function, immunosenescence, autoimmunity and infectious diseases. Among the topics covered are quantitative flow cytometry for Toll-like receptor expression and function; multidimensional single cell mass cytometry (CyTOF) in complex immune interactions and tumor immunity; imaging techniques such as Imagestream high resolution microscopy coupled to flow cytometry, immune cell infiltration of organotypic, biomimetic organs; high-throughput single cell secretion profiling; multiplexed transcriptomic profiling; microsatellite and microRNA methodologies, RNA interference; and the latest bioinformatics and biostatistical methodologies, including in-depth statistical modeling, genetic mapping, and systems approaches.

The Innate Immune System

The Innate Immune System Book
Author : Tom Monie
Publisher : Academic Press
Release : 2017-02-16
ISBN : 0081007582
Language : En, Es, Fr & De

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Book Description :

The Innate Immune System: A Compositional and Functional Perspective focuses on the components and functionality of the innate immune system, detailing how they work in their own right, and then progressing to cover their relevance to disease and how they interface with the adaptive response. Despite the growing appreciation of the importance of the innate immune system, many classical immunology books still focus predominantly on the adaptive immune response. Not only is this unbalanced, but it fails to reflect the growing synergy between the activation and function of the innate response and the final nature of adaptive response. This book fills the gap in knowledge that is needed to fully understand and appreciate the topic. Provides a clear, but simple picture of the main principle of innate immunity and the interlink with adaptive responses Fulfills an unmet need in the area of innate immunity Gives a constructive and progressive approach to introducing and explaining the key players in the innate immune response Introduces and explains the key players in the innate immune response with a constructive and progressive approach Presents the components of the innate response and shows how these interrelated areas connect with one another from a functional perspective Enables the reader to gradually increase their level of understanding and knowledge without the risk of becoming confused, thereby ensuring they fully comprehend the integrated signaling pathways

The Polarization and Regulation of Type 2 Innate Immune Responses

The Polarization and Regulation of Type 2 Innate Immune Responses Book
Author : Kanade Shinkai
Publisher : Unknown
Release : 2002
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Download The Polarization and Regulation of Type 2 Innate Immune Responses book written by Kanade Shinkai, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The Role of IFN alpha beta in the Innate Immune Response to African Trypanosomes

The Role of IFN  alpha   beta  in the Innate Immune Response to African Trypanosomes Book
Author : Rebecca Lopez
Publisher : Unknown
Release : 2007
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download The Role of IFN alpha beta in the Innate Immune Response to African Trypanosomes book written by Rebecca Lopez, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.