Skip to main content

Inhaled Medicines

In Order to Read Online or Download Inhaled Medicines Full eBooks in PDF, EPUB, Tuebl and Mobi you need to create a Free account. Get any books you like and read everywhere you want. Fast Download Speed ~ Commercial & Ad Free. We cannot guarantee that every book is in the library!

Inhaled Medicines

Inhaled Medicines Book
Author : Stavros Kassinos,Per Bäckman,Joy Conway,Anthony J. J. Hickey
Publisher : Academic Press
Release : 2021-01-20
ISBN : 0128149752
Language : En, Es, Fr & De

GET BOOK

Book Description :

Inhaled medicines are widely used to treat pulmonary and systemic diseases. The efficacy and safety of these medicines can be influenced by the deposited fraction, the regional deposition pattern within the lungs and by post-depositional events such as drug dissolution, absorption and clearance from the lungs. Optimizing performance of treatments thus requires that we understand and are able to quantify these product and drug attributes. Inhaled Medicines: Optimizing Development through Integration of In Silico, In Vitro and In Vivo Approaches explores the current state of the art with respect to inhalation drug delivery, technologies available to assess product performance, and novel in silico methods now available to link in vitro product performance to clinical performance. Recent developments in the latter field, especially the prospect of integration of three-dimensional Computational Fluid Particle Methods (3D-CFPD) with physiologically based pharmacokinetic (PBPK models), unlocks the potential for in silico population studies that can help inform and optimize treatment and product development strategies. In this highly multidisciplinary field, where progress occurs at the intersection of several disciplines of engineering and science, this work aims to integrate current knowledge and understanding and to articulate a clear vision for future developments. ● Considers the healthcare needs driving the field, and where inhaled drugs could have the maximum impact ● Gives a concise account of the state of the art in key areas and technologies such as device and formulation technologies, clinically relevant in vitro performance assessment, medical imaging, as well as in silico modelling and simulation ● Articulates how the combination of in vitro product performance data, medical imaging and simulations technologies in the framework of large scale in silico pre-clinical trials could revolutionize the field ● Provides systematic and thorough referencing to sources offering a more-in-depth analysis of technical issues

Pharmacokinetic modifying Effects of Glycerol in Inhaled Medicines

Pharmacokinetic modifying Effects of Glycerol in Inhaled Medicines Book
Author : Wachirun Terakosolphan
Publisher : Unknown
Release : 2019
ISBN : 0987650XXX
Language : En, Es, Fr & De

GET BOOK

Book Description :

Download Pharmacokinetic modifying Effects of Glycerol in Inhaled Medicines book written by Wachirun Terakosolphan, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Equivalence Testing of Inhaled Drugs

Equivalence Testing of Inhaled Drugs Book
Author : Marjolein Weda
Publisher : Unknown
Release : 2007
ISBN : 9789036728966
Language : En, Es, Fr & De

GET BOOK

Book Description :

Download Equivalence Testing of Inhaled Drugs book written by Marjolein Weda, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Pulmonary Drug Delivery

Pulmonary Drug Delivery Book
Author : Ali Nokhodchi,Gary P. Martin
Publisher : John Wiley & Sons
Release : 2015-06-01
ISBN : 1118799526
Language : En, Es, Fr & De

GET BOOK

Book Description :

Drug therapy via inhalation route is at the cutting edge of modern drug delivery research. There has been significant progress on the understanding of drug therapy via inhalation products. However, there are still problems associated with their formulation design, including the interaction between the active pharmaceutical ingredient(s) (APIs), excipients and devices. This book seeks to cover some of the most pertinent issues and challenges of such formulation design associated with industrial production and desirable clinical outcome. The chapter topics have been selected with a view to integrating the factors that require consideration in the selection and design of device and formulation components which impact upon patient usability and clinical effectiveness. The challenges involved with the delivery of macromolecules by inhalation to both adult and pediatric patients are also covered. Written by leading international experts from both academia and industry, the book will help readers (formulation design scientists, researchers and post-graduate and specialized undergraduate students) develop a deep understanding of key aspects of inhalation formulations as well as detail ongoing challenges and advances associated with their development.

Pharmacology and Therapeutics of Asthma and COPD

Pharmacology and Therapeutics of Asthma and COPD Book
Author : Clive P. Page,Peter J. Barnes
Publisher : Springer
Release : 2017-02-06
ISBN : 3319521756
Language : En, Es, Fr & De

GET BOOK

Book Description :

The present volume is supposed to be a major reference resource for chest physicians and those involved in the development of novel pharmaceutical entities for these diseases. Internationally recognized authorities review the most important new information on the advances in our understanding of the pathogenesis and treatment of these diseases, including the substantial advances in the topical delivery of inhaled medicines. Each chapter is extensively referenced, generously illustrated with clear diagrams and photographs, and represents a state-of-the-art review of this important area of respiratory medicine.

Leachables and Extractables Handbook

Leachables and Extractables Handbook Book
Author : Douglas J. Ball,Daniel L. Norwood,Cheryl L. M. Stults,Lee M. Nagao
Publisher : John Wiley & Sons
Release : 2012-02-08
ISBN : 1118147685
Language : En, Es, Fr & De

GET BOOK

Book Description :

A practical and science-based approach for addressingtoxicological concerns related to leachables and extractablesassociated with inhalation drug products Packaging and device components of Orally Inhaled and Nasal DrugProducts (OINDP)—such as metered dose inhalers, dry powderinhalers, and nasal sprays—pose potential safety risks fromleachables and extractables, chemicals that can be released ormigrate from these components into the drug product. Addressing theconcepts, background, historical use, and development of safetythresholds and their utility for qualifying leachables andextractables in OINDP, the Leachables and Extractables Handbooktakes a practical approach to familiarize readers with the recentrecommendations for safety and risk assessment established througha joint effort of scientists from the FDA, academia, and industry.Coverage includes best practices for the chemical evaluation andmanagement of leachables and extractables throughout thepharmaceutical product life cycle, as well as: Guidance for pharmaceutical professionals to qualify andrisk-assess container closure system leachables and extractables indrug products Principles for defining toxicological safety thresholds that areapplicable to OINDP and potentially applicable to other drugproducts Regulatory perspectives, along with an appendix of key terms anddefinitions, case studies, and sample protocols Analytical chemists, packaging and device engineers, formulationdevelopment scientists, component suppliers, regulatory affairsspecialists, and toxicologists will all benefit from the wealth ofinformation offered in this important text.

Pharmaceutical Inhalation Aerosol Technology Third Edition

Pharmaceutical Inhalation Aerosol Technology  Third Edition Book
Author : Anthony J. Hickey,Sandro R. da Rocha
Publisher : CRC Press
Release : 2019-03-26
ISBN : 0429619561
Language : En, Es, Fr & De

GET BOOK

Book Description :

This fully revised and updated third edition of Pharmaceutical Inhalation Aerosol Technology encompasses the scientific and technical foundation for the rationale, design, componentry, assembly and quality performance metrics of therapeutic inhalers in their delivery of pharmaceutical aerosols to treat symptoms or the underlying causes of disease. It focuses on the importance of pharmaceutical engineering as a foundational element of all inhaler products and their application to pulmonary drug delivery. The expanded scope considers previously unaddressed aspects of pharmaceutical inhalation aerosol technology and the patient interface by including aerosol delivery, lung deposition and clearance that are used as measures of effective dose delivery.

Inhalation Drug Delivery

Inhalation Drug Delivery Book
Author : Paolo Colombo,Daniela Traini,Francesca Buttini
Publisher : John Wiley & Sons
Release : 2012-12-19
ISBN : 1118397169
Language : En, Es, Fr & De

GET BOOK

Book Description :

There has been a rapid evolution in the field of inhalation drug therapy, including new drugs, increased regulation and quality control, and strong pressure from generics. Inhalation Drug Therapy brings together the most current inhalation drug research, as well as practical developments and processes, into one essential guide. Focusing on inhalation products and specific equipment and techniques used in manufacturing and quality control, the book balances research with the industrial aspects of creating the drugs, and features a highly regarded author team with both academic and industry experience.

U S News World Report

U S  News   World Report Book
Author : Anonim
Publisher : Unknown
Release : 2009
ISBN : 0987650XXX
Language : En, Es, Fr & De

GET BOOK

Book Description :

Download U S News World Report book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Nanoparticles in medicine and environment

Nanoparticles in medicine and environment Book
Author : J.C. Marijnissen,Leon Gradon
Publisher : Springer Science & Business Media
Release : 2009-12-01
ISBN : 9789048126323
Language : En, Es, Fr & De

GET BOOK

Book Description :

A huge effort is put into the science of nanoparticles and their production. In many cases it is unavoidable that nanoparticles are released into the environment, either during the production processes or during the use of a product made from these particles. It is also realized that combustion processes like traffic and power plants release nanoparticles into the atmosphere. However it is not known how nanoparticles interact with the human body, especially upon inhalation. At the same time research activities are devoted to understand how nano-sized medicine particles can be used to administer medicines via inhalation. In any case it is absolutely necessary to know how the nanoparticles interfere with the inhalation system, how they deposit and affect on the human system. Three main themes are discussed: Nanoparticle sources and production Nanoparticle inhalation and deposition Toxicological and medical consequences of nanoparticles Each theme is covered comprehensively, starting at nano-quantum effects up to technical and medical applications such as measuring equipment and inhalation instrumentation. This book brings together all sub-disciplines in the field related to aerosol nanoparticles. Each chapter is written by a world expert, giving the state of the art information and challenging open questions. The last chapter summarizes in an interdisciplinary way what is already known and what still is ahead of us.

Lung Disposition Model based Analyses of Clinical Pharmacokinetic Profiles for Inhaled Drugs

Lung Disposition Model based Analyses of Clinical Pharmacokinetic Profiles for Inhaled Drugs Book
Author : Anuja Raut
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

GET BOOK

Book Description :

There has been a desire to accurately interpret the inhaled pharmacokinetic (PK) profiles of drugs in humans to aid successful inhaled drug and product developments. However, challenges are layered, as 1) the drug dose delivered to the lung (DTL) from inhalers is a portion of the formulated dose but rarely determined; 2) lung delivery and regional deposition differ, depending on drug, formulation and inhaler; 3) drugs are not only absorbed from the lung but may also be from the gastrointestinal (GI) tract; and 4) in addition to absorption into the systemic circulation, multiple non-absorptive processes also eliminate drugs from the lung, such as mucociliary clearance, metabolism, phagocytosis and tissue binding. Hence, this thesis project aims to develop new lung disposition model-based analyses to derive the meaningful kinetic descriptors for lung disposition from inhaled PK profiles in humans. Two approaches, curve fitting- and moment-based approaches, were developed. Both approaches modeled the kinetics of lung disposition rate-controlled by absorption (ka) and non-absorptive loss (knal), assuming no contribution of GI absorption. An exhaustive literature review found necessary data sets for three drugs, tobramycin, calcitonin and ciprofloxacin. In the curve fitting-based approach, each inhaled PK profile was fitted to the lung disposition model, while the DTL was obtained from corresponding 1̐ʹ-scintigraphic lung deposition and the kinetic parameters of systemic disposition were fixed by separate intravenous PK profile model analysis. In the moment analysis-based approach, the mean lung residence times (MLRT) and the DTL-based bioavailability (FL) were estimated and used to determine the ka and knal values in the lung disposition model, given FL = MLRT·ka = ka/(ka+knal). The ka and knal values were successfully derived for all the three drugs delivered by dry powder inhalers (DPIs) and/or nebulizers (NEB) through both approaches. Their "goodness-of-fit" was reasonably satisfactory. The ka values appeared to be primarily described by partition-based diffusion affected by the three hydrophilic drug's molecular weight. In contrast, the knal values differed, yet appeared to become plausible, with a notion of additional non-absorptive confoundedness due to lung tissue binding (tobramycin) and metabolism (calcitonin), in addition to mucociliary clearance. The ka and knal values derived by the two approaches were comparable in majority of the cases. The success of these PK modeling analyses enabled further attempts to identify most influential attributes by simulation. The systemic PK and lung exposure profiles were predicted by simulation upon upon ±20 % changes in each of the DTL, ka and knal values to examine changes in the systemic PK metrics (Cmax, AUC and Tmax) and local lung exposure metrics (AUClung and LRT0.5). For all three drugs, the Cmax and AUC changes were identical to changes in the DTL without changing the Tmax. In contrast, impacts of the ka and knal changes differed between drugs, depending on the relative contribution of the rate constant to their sum (ka+knal). It appeared that the major contributor of the sum (ka+knal) was that rate-controlling the kinetics of lung disposition. In conclusion, this thesis project has successfully proposed two new approaches of curve fitting and moment-based analysis by accurately deriving the kinetic descriptors of lung disposition (ka and knal) for three drugs from the inhaled PK profiles in humans. Their applications were extended to predict likely changes in the systemic PK and local lung exposure metrics by simulation. While attempts should continue with more drugs, these approaches are believed to be useful in identifying critical attributes to determine the lung disposition kinetics and thus predicting the lung kinetic behavior and systemic PK profiles of new drug entities in humans.

The Mechanics of Inhaled Pharmaceutical Aerosols

The Mechanics of Inhaled Pharmaceutical Aerosols Book
Author : Warren H. Finlay
Publisher : Academic Press
Release : 2019-06-01
ISBN : 0081027869
Language : En, Es, Fr & De

GET BOOK

Book Description :

The Mechanics of Inhaled Pharmaceutical Aerosols: An Introduction, Second Edition provides a concise, but thorough exposition of fundamental concepts in the field of pharmaceutical aerosols. This revised edition will allow researchers in the field to gain a thorough understanding of the field from first principles, allowing them to understand, design, develop and improve inhaled pharmaceutical aerosol devices and therapies. Chapters consider mechanics and deposition, specifically in the respiratory tract, while others discuss the mechanics associated with the three existing types of pharmaceutical inhalation devices. This text will be very useful for academics and for courses taught at both undergraduate and graduate levels. Because of the interdisciplinary nature of this book, it will also serve a wide audience that includes engineers and scientists involved with inhaled aerosol therapies. Provides a concise, but thorough exposition of fundamental concepts in the field of pharmaceutical aerosols Allows researchers in the field to gain an up-to-date, thorough understanding of the field from first principles Introduces the pharmaceutical aerosols field to the many engineers and scientists entering the area

Cases illustrative of the efficacy of various medicines administered by inhalation in pulmonary consumption c

Cases illustrative of the efficacy of various medicines administered by inhalation  in pulmonary consumption   c    Book
Author : sir Charles Scudamore
Publisher : Unknown
Release : 1830
ISBN : 0987650XXX
Language : En, Es, Fr & De

GET BOOK

Book Description :

Download Cases illustrative of the efficacy of various medicines administered by inhalation in pulmonary consumption c book written by sir Charles Scudamore, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Inhaled Pharmaceutical Product Development Perspectives

Inhaled Pharmaceutical Product Development Perspectives Book
Author : Anthony J. Hickey
Publisher : Elsevier
Release : 2017-11-23
ISBN : 0128123362
Language : En, Es, Fr & De

GET BOOK

Book Description :

Inhaled Pharmaceutical Product Development Perspectives: Challenges and Opportunities describes methods and procedures for consideration when developing inhaled pharmaceuticals, while commenting on product development strategies and their suitability to support regulatory submission. It bridges the gap between the aspirations of scientists invested in new technology development and the requirements that must be met for any new product. The book brings together emerging analytical and inhalation technologies, providing perspectives that illuminate formulation and device design, development, regulatory compliance, and practice. Focusing on underlying scientific and technical principles known to be acceptable from the current regulatory perspective, this monograph will remain useful as a high-level guide to inhaled product development for the foreseeable future. Discusses development strategies and best practices in the context of regulatory requirements Written by a broadly qualified expert drawing on the knowledge and critical opinions of key individuals in the field Includes a foreword by Charles G. Thiel

Cases illustrative of the efficacy of various medicines administered by inhalation in preliminary consumption in certain morbid states of the trachea and bronchial tubes attended with distressing cough and in asthma

Cases illustrative of the efficacy of various medicines administered by inhalation  in preliminary consumption  in certain morbid states of the trachea and bronchial tubes  attended with distressing cough  and in asthma Book
Author : Sir Charles SCUDAMORE
Publisher : Unknown
Release : 1830
ISBN : 0987650XXX
Language : En, Es, Fr & De

GET BOOK

Book Description :

Download Cases illustrative of the efficacy of various medicines administered by inhalation in preliminary consumption in certain morbid states of the trachea and bronchial tubes attended with distressing cough and in asthma book written by Sir Charles SCUDAMORE, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Aerosols in Medicine

Aerosols in Medicine Book
Author : Folke Morén
Publisher : Elsevier Science Limited
Release : 1993
ISBN : 0987650XXX
Language : En, Es, Fr & De

GET BOOK

Book Description :

This edition includes chapters on the diagnostic and therapeutic use of aerosols, systemic therapy, and particle size analysis of therapeutic aerosols. It reviews the current state-of-the-art, details important applications and assesses environmental and occupational aerosols.

Advances in Pulmonary Drug Delivery

Advances in Pulmonary Drug Delivery Book
Author : Philip Chi Lip Kwok,Hak-Kim Chan
Publisher : CRC Press
Release : 2016-12-19
ISBN : 1315311968
Language : En, Es, Fr & De

GET BOOK

Book Description :

The respiratory tract has been used to deliver biologically active chemicals into the human body for centuries. However, the lungs are complex in their anatomy and physiology, which poses challenges to drug delivery. Inhaled formulations are generally more sophisticated than those for oral and parenteral administration. Pulmonary drug development is therefore a highly specialized area because of its many unique issues and challenges. Rapid progress is being made and offers novel solutions to existing treatment problems. Advances in Pulmonary Drug Delivery highlights the latest developments in this field.

Case Studies in Modern Drug Discovery and Development

Case Studies in Modern Drug Discovery and Development Book
Author : Xianhai Huang,Robert G. Aslanian
Publisher : John Wiley & Sons
Release : 2012-04-19
ISBN : 1118219678
Language : En, Es, Fr & De

GET BOOK

Book Description :

Learn why some drug discovery and development efforts succeed . . . and others fail Written by international experts in drug discovery and development, this book sets forth carefully researched and analyzed case studies of both successful and failed drug discovery and development efforts, enabling medicinal chemists and pharmaceutical scientists to learn from actual examples. Each case study focuses on a particular drug and therapeutic target, guiding readers through the drug discovery and development process, including drug design rationale, structure-activity relationships, pharmacology, drug metabolism, biology, and clinical studies. Case Studies in Modern Drug Discovery and Development begins with an introductory chapter that puts into perspective the underlying issues facing the pharmaceutical industry and provides insight into future research opportunities. Next, there are fourteen detailed case studies, examining: All phases of drug discovery and development from initial idea to commercialization Some of today's most important and life-saving medications Drugs designed for different therapeutic areas such as cardiovascular disease, infection, inflammation, cancer, metabolic syndrome, and allergies Examples of prodrugs and inhaled drugs Reasons why certain drugs failed to advance to market despite major research investments Each chapter ends with a list of references leading to the primary literature. There are also plenty of tables and illustrations to help readers fully understand key concepts, processes, and technologies. Improving the success rate of the drug discovery and development process is paramount to the pharmaceutical industry. With this book as their guide, readers can learn from both successful and unsuccessful efforts in order to apply tested and proven science and technologies that increase the probability of success for new drug discovery and development projects.

Handbook of Lung Targeted Drug Delivery Systems

Handbook of Lung Targeted Drug Delivery Systems Book
Author : Yashwant Pathak,Nazrul Islam
Publisher : CRC Press
Release : 2021-10-18
ISBN : 1000450767
Language : En, Es, Fr & De

GET BOOK

Book Description :

Handbook of Lung Targeted Drug Delivery Systems: Recent Trends and Clinical Evidences covers every aspect of the drug delivery to lungs, the physiology and pharmacology of the lung, modelling for lung delivery, drug devices focused on lung treatment, regulatory requirements, and recent trends in clinical applications. With the advent of nano sciences and significant development in the nano particulate drug delivery systems there has been a renewed interest in the lung as an absorption surface for various drugs. The emergence of the COVID-19 virus has brought lung and lung delivery systems into focus, this book covers new developments and research used to address the prevention and treatment of respiratory diseases. Written by well-known scientists with years of experience in the field this timely handbook is an excellent reference book for the scientists and industry professionals. Key Features: Focuses particularly on the chemistry, clinical pharmacology, and biological developments in this field of research. Presents comprehensive information on emerging nanotechnology applications in diagnosing and treating pulmonary diseases Explores drug devices focused on lung treatment, regulatory requirements, and recent trends in clinical applications Examines specific formulations targeted to pulmonary systems