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Inflammation And Natural Products

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Research Focus on Natural Products and the Body s Immune and Inflammatory Systems

Research Focus on Natural Products and the Body s Immune and Inflammatory Systems Book
Author : Kyoungho Suk
Publisher : Nova Publishers
Release : 2007
ISBN : 9781600217517
Language : En, Es, Fr & De

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Book Description :

The definition of 'natural' is 'produced or existing in nature.' Natural products refer to as any natural constituents, natural substances, or a group of the secondary metabolites that derive from plants, insects, marine plants and animals through their own metabolic pathways. Natural products are usually of high value and small quantity, and they have a variety of biological activities. Extensive research has been performed to understand the effects of natural products on the immune and inflammatory systems. However, the results have been published individually focusing on a particular aspect of immunity or inflammation. The readers in this field may benefit from a comprehensive review book that describes different aspects of immune/inflammatory responses together. This book provides an overview of how a variety of naturally occurring compounds may influence the body's immune and inflammatory systems with an emphasis on the actions of medicinal herbs. In this book, experts in each field present their recent data on the mechanisms by which natural products influence the immune and inflammatory responses. The experimental results that are described in this book are based on various in vitro as well as in vivo model systems. It is also discussed how such effects of natural products are related with their therapeutic applications for the treatment of immune and inflammatory diseases.

Terpenes from Natural Products with Potential Anti Inflammatory Activity

Terpenes from Natural Products with Potential Anti Inflammatory Activity Book
Author : Roberto José Serrano
Publisher :
Release : 2018
ISBN :
Language : En, Es, Fr & De

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Book Description :

The development and progression of many diseases is related with an inflammatory process, which could affect different organs or tissues. Currently, many drugs are used to treat inflammation. However, some of these compounds induce severe side effects. For this reason, the search of new therapeutic options for the treatment of inflammation is very desirable. Medicinal plants have been an interesting source for obtaining new active compounds, including several terpenes and terpenoids with anti-inflammatory activity. This book chapter includes 62 sesquiterpenes, 34 diterpenes, and 22 triterpenes with anti-inflammatory activity. The anti-inflammatory effect was evaluated using in vitro, in vivo, and both models. These terpenes were obtained from 44 plant species belonging to 25 botanical families. Eight of theses species belong to the Asteraceae family and four to Lamiaceae family, respectively, and the other species belong to 13 different botanical families, one sesquiterpene was obtained from a sponge and two diterpenes were isolated from corals.

Bioactive Natural Products Detection Isolation and Structural Determination

Bioactive Natural Products Detection  Isolation  and Structural Determination Book
Author : Steven M. Colegate,Russell J. Molyneux
Publisher : CRC Press
Release : 1993-09-29
ISBN : 9780849343728
Language : En, Es, Fr & De

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Book Description :

Bioactive Natural Products covers all the aspects of bioactive natural product research from ethnobotanical investigations to modern, technologically assisted isolation and structural determination of active compounds. An internationally selected group of experts share their knowledge of a wide range of bioactivities and chemical compound classes. Topics in the chapters describing the modern application of detection, isolation, and structural determination techniques are strongly supported by chapters detailing and reviewing research involving various classes of bioactivity. Research areas include the immunomodulatory, antiviral, cytotoxic, anti-inflammatory, and insect behavior classes of bioactivity. Extensive referencing throughout the text is helpful to those readers not familiar with this subject and serves as a critical review for more experienced researchers. The book is also excellent for upper division or post-graduate courses.

Discovery and Development of Anti inflammatory Agents from Natural Products

Discovery and Development of Anti inflammatory Agents from Natural Products Book
Author : Goutam Brahmachari
Publisher : Elsevier
Release : 2019-07-11
ISBN : 0128169931
Language : En, Es, Fr & De

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Book Description :

Discovery and Development of Anti-inflammatory Agents from Natural Products, the latest volume in the Natural Product Drug Discovery series, presents cutting-edge research advances in the field of bioactive natural products and natural drug formulations, with this volume focusing on molecules of natural origin and their synthetic analogues that have the potential to act against the pathogens responsible for inflammatory diseases. All aspects of each are covered, including isolations and structure elucidations, in vitro and in vivo biological activity, synthetic optimization, investigations of pharmacodynamics and kinetics, and the structure-activity relationships of anti-inflammatory natural products. Written by active researchers and leading experts, this book brings together an overview of current discoveries and trends in this field. It will be a valuable resource for researchers working to discover promising leads for the development of pharmaceuticals in the prevention and treatment of anti-inflammatory diseases. Features contributions from active researchers and leading experts working in medicinal natural products and herbal formulations Includes recent, cutting-edge advances on medicinal natural products, along with preventative therapies for different kinds of inflammation-directed diseases Offers an authoritative source of information on the industrial application of natural products for medicinal purposes

Pharmaceutical and Bioactive Natural Products

Pharmaceutical and Bioactive Natural Products Book
Author : David H. Attaway,Oskar R. Zaborsky
Publisher : Springer Science & Business Media
Release : 1993-03-31
ISBN : 9780306441745
Language : En, Es, Fr & De

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Book Description :

Biotechnology may be defined as the application of scientific and engineering principles to the processing of materials by biological agents to provide goods and services (Bullet al. , 1982, p. 21) or as any technique that uses living organisms (or parts of organisms) to make or modify products, to improve plants or animals, or to develop microorganisms for specific use (OTC, 1988). In line with these broad definitions we can consider marine biotechnology as the use of marine organisms or their constituents for useful purposes in a controlled fashion. This series will explore a range of scientific advances in support of marine biotechnology. It will provide information on advances in three categories: (1) basic knowledge, (2) ap plied research and development, and (3) commercial and institutional issues. We hope the presentation of the topics will generate interest and interaction among readers in the academic world, government, and industry. This first volume examines chemical and biological properties of some natural products that are useful or potentially useful in research and in the chemical and pharmaceutical industries. One chapter describes a system for producing such substances on a large scale. Biotechnology incorporates molecular biology in order to go beyond tradi tional biochemical technology such as the production of antibiotic drugs from bacterial cultures in bioreactors. Development of the technology for production of antibiotics in this way resulted from fundamental advances in chemistry, phar macology, microbiology, and biochemical engineering.

Studies in Natural Products Chemistry

Studies in Natural Products Chemistry Book
Author : Atta-ur-Rahman
Publisher : Elsevier
Release : 2020
ISBN : 0128179066
Language : En, Es, Fr & De

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Book Description :

Studies in Natural Products Chemistry: Bioactive Natural Products (Part XII), Volume 65, is the latest in a series that covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting-edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products. Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to quickly isolate and determine the structures and biological activity of natural products, thus opening up exciting opportunities in the field of new drug development to the pharmaceutical industry. Focuses on the chemistry of bioactive natural products Contains contributions by leading authorities in the field Presents sources of new pharmacophores

Inflammation Natural Resources and Its Applications

Inflammation  Natural Resources and Its Applications Book
Author : Parag Jain,Ravindra Pandey,Shiv Shankar Shukla
Publisher : Springer
Release : 2014-12-04
ISBN : 813222163X
Language : En, Es, Fr & De

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Book Description :

Inflammation is the very natural process of our body; it does its work immediately and smoothly along with lots of helpers. Inflammation is linked to immune system as acute inflammatory or pro-inflammatory phase through macrophage activation. This book is for researchers and scholars in the field of life sciences and medical sciences. The book contains all inflammatory sources around the world. It emphasizes on anti-inflammatory sources along with its active inflammatory constituents and other medicinal uses with authentic references. Anti-inflammation is a kind of activity with is found in nearly all of the natural sources used for major biological activities. So, the book helps them to correlate their activity of interest with anti-inflammatory source. The present work deals with illustrative representation of inflammation, causes of inflammation, inflammatory mediators, anti-inflammatory sources other uses and inflammation and lifestyle. It mainly provides the researchers the updated information from the ancient to the most recent ongoing research on inflammation. This book imparts pace to their idea of thinking, assist to make clear predictions before proceeding to research. The introduction includes natural sources of inflammation and its benefits; the sources are from plant, animal and marine. The book tells how these sources are useful for us to cure several diseases and opens new path for further research. Inflammation part of the book is well presented along with its phases, types and other diseases interrelated with inflammation. Inflammatory mediators, the foremost player of inflammation are defined in a very pleasant and convenient manner. The chapter includes both cell- derived and plasma - derived mediators illustratively with their synthesis and action. Natural source of anti-inflammation is the heart chapter of this book which contains all anti-inflammation sources from plants, marine and animals. This chapter also contains short description of most of the sources, its availability and uses. The authors have also added inflammatory models for assessment of biological activities of natural sources both in vitro and in vivo. Inflammation free lifestyle is described very nicely in the book. The contents are very specific and relevant to its topic; all the data provided is unique and useful. The anti-inflammatory table includes sources, plant parts used, active constituents and other uses. This data provides ample information regarding anti-inflammatory research and innovation. The highlights of this book shall be: -Describes almost all anti-inflammatory sources around the globe at one place in a more convenient tabulated form -Illustrative representation makes the book more attractive and interactive

Plant Natural Products for Human Health

Plant Natural Products for Human Health Book
Author : Chun-Tao Che,Hongjie Zhang
Publisher : MDPI
Release : 2019-03-21
ISBN : 3038977128
Language : En, Es, Fr & De

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Book Description :

Plants have served mankind as an important source of foods and medicines. While we all consume plants and their products for nutritional support, a majority of the world population also rely on botanical remedies to meet their health needs, either as their own “traditional medicine” or as “complementary and alternative medicine”. From a pharmaceutical point of view, many compounds obtained from plant sources have long been known to possess bio/pharmacological activities, and historically, plants have yielded many important drugs for human use, from morphine discovered in the early nineteenth century to the more recent paclitaxel and artemisinin. Today, we are witnessing a global resurgence in interest and use of plant-based therapies and botanical products, and natural products remain an important and viable source of lead compounds in many drug discovery programs. This Special Issue on “Plant Natural Products for Human Health” compiles a series of scientific reports to demonstrate the medicinal potentials of plant natural products. It covers a range of disease targets, such as diabetes, inflammation, cancer, neurological disease, cardiovascular disease, liver damage, bacterial, and fungus infection and malarial. These papers provide important insights into the current state of research on drug discovery and new techniques. It is hoped that this Special Issue will serve as a timely reference for researchers and scholars who are interested in the discovery of potentially useful molecules from plant sources for health-related applications.

The Benefits of Natural Products for Neurodegenerative Diseases

The Benefits of Natural Products for Neurodegenerative Diseases Book
Author : M. Mohamed Essa,Mohammed Akbar,Gilles Guillemin
Publisher : Springer
Release : 2016-09-20
ISBN : 3319283839
Language : En, Es, Fr & De

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Book Description :

Focuses on the effects of natural products and their active components on brain function and neurodegenerative disease prevention. Phytochemicals such as alkaloids, terpenes, flavanoids, isoflavones, saponins etc are known to possess protective activity against many neurological diseases. The molecular mechanisms behind the curative effects rely mainly on the action of phytonutrients on distinct signaling pathways associated with protein folding and neuro-inflammation. The diverse array of bioactive nutrients present in these natural products plays a pivotal role in prevention and cure of various neurodegenerative diseases, disorders, or insults, such as Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, traumatic brain injury, and other neuronal dysfunctions. However, the use of these antioxidants in the management of neurodegenerative conditions has so far been not well understood. This is a comprehensive collection addressing the effects on the brain of natural products and edible items such as reservatrol, curcumin, gingerol, fruits, vegetables, nuts, and marine products.

Lectures on Surgical Pathology

Lectures on Surgical Pathology Book
Author : Sir James Paget
Publisher :
Release : 1860
ISBN :
Language : En, Es, Fr & De

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Book Description :

Copy 1: Signed on title page S.N. Benham, M.D.; copy 2: 1978. Gift of Drs. Berry, Askins, and Suggs of Marion, S.C; copy 3: 1999, Gift of Forde A. McIver, M.D.

Bioactive Natural Products

Bioactive Natural Products Book
Author : Goutam Brahmachari
Publisher : John Wiley & Sons
Release : 2015-01-20
ISBN : 3527684425
Language : En, Es, Fr & De

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Book Description :

Natural compounds, which have evolved their function over millions of years, are often more efficient than man-made compounds if a specific biological activity is needed, e.g. as an enzyme inhibitor or as a toxin to kill a cancer cell. This book comprising of sixteen technical chapters, highlights the chemical and biological aspects of potential natural products with an intention of unravelling their pharmaceutical applicability in modern drug discovery processes. Key features: Covers the synthesis, semi-synthesis and also biosynthesis of potentially bioactive natural products Features chemical and biological advances in naturally occurring organic compounds describing their chemical transformations, mode of actions, and structure-activity relationships 40 expert scientists from around the world report their latest findings and outline future opportunities for the development of novel and highly potent drugs based on natural products operating at the interface of chemistry and biology Forward-looking: Addresses opportunities and cutting-edge developments rather than well-documented basic knowledge, pinpoints current trends and future directions in this rapidly-evolving field Application-oriented: Throughout the book, the focus is on actual and potential applications in pharmacology and biotechnology This book is an essential resource for natural products chemists, medicinal chemists, biotechnologists, biochemists, pharmacologists, as well as the pharmaceutical and biotechnological industries.

Obesity Inflammation and Cancer

Obesity  Inflammation and Cancer Book
Author : Andrew J. Dannenberg,Nathan A. Berger
Publisher : Springer Science & Business Media
Release : 2013-05-21
ISBN : 1461468191
Language : En, Es, Fr & De

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Book Description :

In addition to its metabolic and endocrinologic effects, obesity and adipose tissue have now been shown to be associated with low grade inflammation resulting in cellular and humoral inflammatory factors of which the latter may act by endocrine, paracrine and autocrine mechanisms. These inflammatory mediators have increasingly been suggested as contributing to the obesity link to carcinogenesis and cancer promotion. This volume of Energy Balance and Cancer will focus on recent developments and cutting edge research pointing to inflammation and inflammatory factors as key mediators of this linkage. The volume first provides information on inflammation as an important link between obesity and insulin resistance, which is in itself linked to promotion of cancer through hyperinsulinemia. The volume then covers some of the most important mechanisms by which obesity leads to inflammation, including the novel inflammasome concept, alterations in chromatin structure, circulating inflammatory factors, unique cellular interactions between adipocytes and macrophages and the direct link of dietary fat to inflammation and cancer. Overall, this volume will provide important insight to help understand how inflammation may help modulate the linkage between obesity and cancer and serve as a platform for developing future research in this area.

Mode of Action and Target Identification of Anti inflammatory Natural Products

Mode of Action and Target Identification of Anti inflammatory Natural Products Book
Author : Stefanie König
Publisher :
Release : 2019*
ISBN :
Language : En, Es, Fr & De

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Book Description :

In the present thesis, the mode of action of three different natural secondary metabolites was clarified in human cancer cells and primary immune cells. The investigated compounds of this work were (I) the mycotoxin gliotoxin from Aspergillus fumigatus targeting leukotriene A4 hydrolase (LTA4H) resulting in a reduction of the biosynthesis of the neutrophil chemoattractant leukotriene B4 (LTB4) in vivo and in vitro. Furthermore, gliotoxin caused a reduced neutrophil infiltration into the peritoneal cavity. Interestingly, gliotoxin suppressed solely LTB4 formation without compromising other eicosanoids identifying thereby the cause of neutropenia during invasive aspergillosis (IA). However, gliotoxin failed to impede LTA4H activity in non-cellular systems but pre-incubation with GSH enables inhibition of LTA4H activity by gliotoxin indicating that reducing conditions were crucial to cleave the intramolecular disulfide bond. The formed free thiol groups chelated the zinc ion in the active epoxide hydrolase center of LTA4H. Second (II), the melleolide dehydroarmillylorsellinate (DAO) exhibiting, on the one hand, anti-inflammatory features by abrogating 5-lipoxygenase (5-LOX) product formation due to an interaction with surface cysteines especially C159 located at the entrance to the active center of 5-LOX hampering the interaction between 5-LOX and the 5-LOX activating protein (FLAP), and on the other hand, manipulate monocyte functions by covalent binding of the cellular membrane constituent phosphatidylethanolamine (PE). And finally (III), myxochelin A biosynthesized by Pyxidicoccus fallax hampering 5-LOX activity due to iron chelation by the catechol basic structure. Over the last decades, the link between inflammation and cancer gains relevance. Hence, it is important to investigate new anti-inflammatory drugs to prevent chronic diseases, and to elucidate the mechanism of action of cytotoxic compounds to develop new strategies of action for anti-cancer drugs.

Inflammation Mediators Advances in Research and Application 2013 Edition

Inflammation Mediators   Advances in Research and Application  2013 Edition Book
Author : N.A
Publisher : ScholarlyEditions
Release : 2013-05-01
ISBN : 1490101152
Language : En, Es, Fr & De

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Book Description :

Inflammation Mediators—Advances in Research and Application: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about ZZZAdditional Research in a concise format. The editors have built Inflammation Mediators—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about ZZZAdditional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Inflammation Mediators—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.