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Infection And Autoimmunity

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Idiotypes in Medicine Autoimmunity Infection and Cancer

Idiotypes in Medicine  Autoimmunity  Infection and Cancer Book
Author : R.C. Kennedy,S. Ferrone,Yehuda Shoenfeld
Publisher : Elsevier
Release : 1997-11-19
ISBN : 9780080534435
Language : En, Es, Fr & De

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Book Description :

This is the most comprehensive review of the idiotypic network available. All the current knowledge of idiotypes of the various antibodies is incorporated in this volume. The pathogenic role of idiotypes in autoimmunity and cancer is reviewed in depth. The therapeutic part focusses on harnessing anti-idiotypes for treating autoimmunological disorders, and on the employment of idiotypes for vaccines in cancer and infectious diseases, as well as explaining the manipulation of the idiotypic network in autoimmunity and cancer idiotypes and vaccines.

Infection and Autoimmunity

Infection and Autoimmunity Book
Author : Yehuda Shoenfeld,Nancy Agmon-Levin,Noel R Rose
Publisher : Elsevier
Release : 2015-01-27
ISBN : 0444632727
Language : En, Es, Fr & De

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Book Description :

Autoimmune diseases are conditions where the immune system attacks the body organs instead of foreign invaders. This book deals with the various mechanisms by which infectious agents can trigger autoimmunity such as molecular mimicry and polyclonal activation. An overview is given with regard to bacteria, viruses, and parasites associated with autoimmunity, and a summary is given on classical autoimmune diseases and the infecting agents that can induce them. Includes completely updated and new chapters Brings the reader up to date and allows easy access to individual topics in one place Identifies infectious agents as pathogenic or protective in many autoimmune diseases

Vaccines and Autoimmunity

Vaccines and Autoimmunity Book
Author : Yehuda Shoenfeld,Nancy Agmon-Levin,Lucija Tomljenovic
Publisher : John Wiley & Sons
Release : 2015-07-07
ISBN : 1118663438
Language : En, Es, Fr & De

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Book Description :

In light of the discovery of Autoimmune Syndrome Induced by Adjuvants, or ASIA, Vaccines and Autoimmunity explores the role of adjuvants – specifically aluminum in different vaccines – and how they can induce diverse autoimmune clinical manifestations in genetically prone individuals. Vaccines and Autoimmunity is divided into three sections; the first contextualizes the role of adjuvants in the framework of autoimmunity, covering the mechanism of action of adjuvants, experimental models of adjuvant induced autoimmune diseases, infections as adjuvants, the Gulf War Syndrome, sick-building syndrome (SBS), safe vaccines, toll-like receptors, TLRS in vaccines, pesticides as adjuvants, oil as adjuvant, mercury, aluminum and autoimmunity. The following section reviews literature on vaccines that have induced autoimmune conditions such as MMR and HBV, among others. The final section covers diseases in which vaccines were known to be the solicitor – for instance, systemic lupus erythematosus – and whether it can be induced by vaccines for MMR, HBV, HCV, and others. Edited by leaders in the field, Vaccines and Autoimmunity is an invaluable resource for advanced students and researchers working in pathogenic and epidemiological studies.

The Role of Infections in Autoimmune Diseases

The Role of Infections in Autoimmune Diseases Book
Author : Hamidreza Honarmand,Zohreh Zareichian
Publisher : LAP Lambert Academic Publishing
Release : 2015-11-11
ISBN : 9783659797071
Language : En, Es, Fr & De

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Book Description :

Many environmental factors are known to affect the immune system. They may play a role as triggers of autoimmunity. Bacterial, viral and parasitic infections are known to induce and exacerbate autoimmune diseases, mainly by the mechanism of molecular mimicry. Actually viruses and bacteria are the major postulated environmental triggers of autoimmunity. There are multiple mechanisms by which host infection by a pathogen can lead to autoimmunity. The pathogen may carry elements that are similar enough in amino acid sequence or structure to self-antigen. T or B cells that are activated in response to the pathogen are also cross-reactive to self and lead to direct damage and further activation of other arms of the immune system.

Mosaic of Autoimmunity

Mosaic of Autoimmunity Book
Author : Carlo Perricone,Yehuda Shoenfeld
Publisher : Academic Press
Release : 2019-02-15
ISBN : 012814307X
Language : En, Es, Fr & De

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Book Description :

The Mosaic of Autoimmunity: The Novel Factors of Autoimmune Diseases describes the multifactorial origin and diversity of expression of autoimmune diseases in humans. The term implies that different combinations of factors in autoimmunity produce varying and unique clinical pictures in a wide spectrum of autoimmune diseases. Most of the factors involved in autoimmunity can be categorized into four groups: genetic, immune defects, hormonal and environmental factors. In this book, the environmental factors are reviewed, including infectious agents, vaccines as triggers of autoimmunity, smoking and its relationship with rheumatoid arthritis, systemic lupus erythematosus, thyroid disease, multiple sclerosis and inflammatory bowel diseases. An entirely new syndrome, the autoimmune/inflammatory syndrome induced by adjuvants (ASIA), is also included, along with other diseases that are now recognized as having an autoimmune etiopathogenesis. Highlights the concept of the mosaic of autoimmune manifestations Includes new visions on unsuspected molecules Provides updated knowledge to physicians helping patients with autoimmune diseases Presents thorough, up-to-date information on specific diseases, along with clinical applications

Microorganisms and Autoimmune Diseases

Microorganisms and Autoimmune Diseases Book
Author : Herman Friedman,Noel R. Rose,Mauro Bendinelli
Publisher : Springer
Release : 1996-07-31
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Experts in microbiology and autoimmunity examine the association between microorganisms and the development of specific categories of autoimmune diseases. The opening chapters explore the bacterial induction of diseases considered autoimmune in nature. Subsequent chapters describe the role of viruses in the induction of these diseases and of diseases with an autoimmune component. Specific topics include: the role of streptococcal infection in rheumatic fever and the role of Klebsiella in the development of ankylosing spondylitis.

Stress Inducible Cellular Responses

Stress Inducible Cellular Responses Book
Author : U. Feige,R.I. Morimoto,Barbara Polla
Publisher : Birkhäuser
Release : 2013-03-11
ISBN : 3034890885
Language : En, Es, Fr & De

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Book Description :

This book will deal with heat shock proteins and more generally with stress-related inducible gene expression as a pleiotropic adaptive response to stress. It presents a textbook-like overview of the field not only to heat shock experts, but to physiologists, pharmacologists, physicians, neuropsychologists and others as well. It is intended to be a state-of-the-art and perspective book rather than an up-to-date presentation of recent data. It should provide a basis for new experimetal approaches to fields at the edge of the classical heat shock field. Drugs, UV irradiation and environmental toxics will be considered as important modulators of the stress response. Radical scavengers such as superoxide dismutases and inducible regulatory proteins of metallic ion status such as ferritin as well as immunophilins and protein disulfide isomerases will be considered within the frame of stress proteins. The potential practical applications of heat shock proteins in toxicology and medicine for the diagnosis, prognosis and eventually therapy of clinical conditions associated with an increased oxidative burden will be outlined. The role of heat shock proteins in the modulation of immune responses will also be included. The book considers heat shock from a broad perspective including fields for which heat-shock may become of importance in the very near future such as cellular responses to environmental stresses and complex stress responses under specific conditions. It was also felt timely to incorporate a whole section on medical and technological applications of stress proteins. The book will be invaluable for all those working on stress and is intended for every "stress laboratory" as a source of knowledge and perspectives.

The Autoimmune Brain

The Autoimmune Brain Book
Author : David S. Younger
Publisher : Rowman & Littlefield Publishers
Release : 2019-11-10
ISBN : 1538117711
Language : En, Es, Fr & De

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Book Description :

There are millions of people who experience issues related to brain health--depression, attention issues, anxiety, forgetfulness, fatigue, and even chronic pain--yet can’t figure out what’s causing their problems and can’t find any relief. They may have seen a myriad of doctors, many of whom do not take their complaints seriously, or worse, turn to the easy, often inappropriate fix of antidepressants or antianxiety medications. Traditional medications, supplements, or other therapies haven’t worked. No matter what their age--from children to teens or seniors--people and their loved ones are frustrated, scared, and confused by their continued poor health. Countless others display severe psychiatric symptoms that seem to come out of nowhere, ranging from tics, obsessive-compulsive behaviors and anxiety, to depression, bipolar-like mood swings, and even borderline personality disorder and suicidal ideas. . Sometimes, the people affected are the only ones that notices a change to the way they think or feel, and they suffer in silence. Or, they reach out to try to get help, and are all too frequently misdiagnosed. Now, Dr. David Younger, a world-renowned physician, provides relief to these patients and their families. His diagnostic techniques and treatment protocols will help readers identify the true cause of their symptoms and put them on a clear path to healing so they no longer feel unbalanced, out of control, forgetful, and exhausted. THE AUTOIMMUNE BRAIN connects common brain health symptoms to the changes in the immune system, and particularly bacterial, viral, and parasitic infections. In this book, Dr. Younger explains his groundbreaking research and adds a new component: how traumatic stress (whether physical or emotional) and genetics affects this same triad as inextricable factors in initiating disease and brain health symptoms. In fact, a change in personality, behavior, coping style, and one’s emotional state may be the first clue that there is a health problem brewing somewhere else in the body. Readers will find new answers to troubling conditions, including: Alzheimer’s disease Anxiety Arthritis Autism Autonomic disturbances Bacterial and viral infections Bipolar Disorder Cancer Celiac disease and gluten intolerances Chronic Fatigue Syndrome (now referred to as Systemic Exertion Intolerance Disease) Chronic Pain Dementia Depression Endocrine Disorders Immune modulatory therapy using IVIg Lyme disease and co-infections Mast cell activation syndrome Medical cannabis Obsessive Compulsive Disorder Orthostatic hypotension Peripheral Neuropathy Porphyria Post-Traumatic Stress Disorder Postural orthostatic tachycardia

Lymphocyte Updates

Lymphocyte Updates Book
Author : Gheorghita Isvoranu
Publisher : BoD – Books on Demand
Release : 2017-07-12
ISBN : 9535133438
Language : En, Es, Fr & De

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Book Description :

This book represents a synergic effort of an international team of specialists in immunology to expand the scientific achievements in the field of lymphocytes. It offers important and specific updated information to researchers, students, teachers, and medical professionals. Moreover, considering the remarkable dynamics of immunology and immunotherapy, this book "Lymphocyte Updates - Cancer, Autoimmunity, and Infection" aims to represent a significant source of concise scientific data and advancement of knowledge in this field. The chapters offer new insights into the latest scientific progress on lymphocyte roles in protective immunity, as well as their involvement in pathogenesis of various disorders.

Janeway s Immunobiology

Janeway s Immunobiology Book
Author : Kenneth M. Murphy
Publisher : Unknown
Release : 2008
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Janeway s Immunobiology book written by Kenneth M. Murphy, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Regulatory T Cells

Regulatory T Cells Book
Author : Alexander Rudensky,Shimon Sakaguchi
Publisher : Academic Press
Release : 2011-12-06
ISBN : 0123878276
Language : En, Es, Fr & De

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Book Description :

Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future. This volume focuses on regulatory T-cells. Contributions from leading authorities and industry experts Informs and updates on all the latest developments in the field

Infection and Autoimmunity

Infection and Autoimmunity Book
Author : Yehuda Shoenfeld,Nancy Agmon-Levin,Noel Richard Rose,Y. Shoenfeld
Publisher : Elsevier
Release : 2004-09-18
ISBN : 0080534651
Language : En, Es, Fr & De

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Book Description :

Infection and Autoimmunity encompasses the different mechanisms involved in the infection-autoimmunity association/induction. Special attention is given to heat shock proteins (HSPs) and to transgenic mouse models to better understand infection-induced autoimmunity. Organized into six parts, this book first discusses the mechanisms of autoimmune induction by infection. Some chapters follow discussing the vaccination and vaccines, including the controversial issue of vaccine-autoimmunity relationship. Other chapters elucidate the relationship of bacteria and parasites to autoimmunity. Lastly, the aspects of infections and diseases are described. This reference material will help readers gain a deeper insight into the important etiological aspects of autoimmunity. The only book directed at the interactions between infectious agents and autoimmunity Describes the prevalence and incidence of the global issues and current therapeutic approaches Presents the measures for infection control Completely updated, with new chapters One-stop reference with easy access to topics

TCR Affinity and Negative Regulation Limit Autoimmunity microform

TCR Affinity and Negative Regulation Limit Autoimmunity  microform  Book
Author : Matthew Adam Gronski
Publisher : Library and Archives Canada = Bibliothèque et Archives Canada
Release : 2005
ISBN : 9780494077047
Language : En, Es, Fr & De

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Book Description :

Cytotoxic T lymphocytes (CTLs) represent a subset of lymphocytes that are important for effective immune responses to a variety of pathogens including viruses. However, these cells have also been implicated in the development of various autoimmune diseases. This thesis investigates some of the factors that are important during the development of autoimmunity and immune responses. In one study presented here, the importance of high affinity interactions between TCR of naive, autoreactive T cells and peptide/MHC for the development of autoimmunity was evaluated. It was found that high affinity interactions are important for disease development, unless the T cell negative regulatory molecule Cbl-b was missing. The second study was different in that the importance of affinity of self-reactive T cells for peptide/MHC on the tissue was assessed. Surprisingly, high affinity interactions at the target recognition stage were crucial for T cell infiltration into the tissue and disease development. In the final study, the role of the E3 ubiquitin ligase Cbl-b in autoimmunity was evaluated. Using gene deficient animals and a transgenic model of diabetes, it was found that Cbl-b plays a variety of roles in the immune system. It is required to maintain immunological ignorance in vivo and its absence circumvents the need for APC maturation signals to break tolerance and induce autoimmunity. Furthermore, Cbl-b is important in limiting pathogen-induced immune responses. Together, these results contribute to the understanding of factors that regulate the development of autoimmunity.

Autoantibodies and Cytokines

Autoantibodies and Cytokines Book
Author : Wahid Ali Khan
Publisher : Unknown
Release : 2019-04-24
ISBN : 1789848520
Language : En, Es, Fr & De

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Book Description :

The mechanism of autoantibodies cannot be explained without the detail knowledge of cytokines and interferon. These active molecules of immunology are very much dependent on each other and their function cannot be completed without their interaction towards each other. Currently, this the most updated book on this subject that helps the readers/students to upgrade their knowledge by going through chapter by chapter. Contribution by the renounced authors across the globe makes this book really unique and consider as one of the most updated textbook on this subject. This book provides a comprehensive guide to the function and types of autoantibodies and cytokines in basic and clinical field.

Autoimmune Neurology

Autoimmune Neurology Book
Author : Anonim
Publisher : Elsevier
Release : 2016-03-11
ISBN : 0444634460
Language : En, Es, Fr & De

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Book Description :

Autoimmune Neurology presents the latest information on autoimmune neurologic disease, the immune response to the body where organs run wild, causing the immune system to attack itself. Autoimmunity is a main element in numerous nervous system diseases and can target any structure within the central or peripheral nervous system. Over the past 20 years, significant advances in our understanding of the pathophysiology of autoimmune disorders, including the use of biomarkers has led to new diagnosis and treatment options. Neurologic conditions associated with autoimmune reactions include dementia, neuromuscular disease, epilepsy, sleep disorders, diabetes, and other common neurologic disorders and disease. This current tutorial-reference will be a must-have title for clinical neurologists, research neurologists, neuroscientists, and any medical professional working with autoimmune disease and disorders. Includes comprehensive coverage of autoimmune neurology Details the latest techniques for the study, diagnosis, and treatment of diseases and disorders, including dementia, neuromuscular disease, epilepsy, and sleep disorders Presents a focused reference for clinical practitioners and the clinical neurology and neurology research communities

Management of Infections in the Immunocompromised Host

Management of Infections in the Immunocompromised Host Book
Author : Brahm H. Segal
Publisher : Springer
Release : 2018-06-18
ISBN : 3319776746
Language : En, Es, Fr & De

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Book Description :

This book provides a comprehensive, state-of-the-art review of the concepts vital to a modern treatment of common and opportunistic infections in the immunocompromised host. Chapters are written by experts in the field, and include their views on gaps in the field and future directions of research. This book begins with an overview of the normally functioning immune system followed by a detailed discussion of the major primary immunodeficiencies. Specific chapters are dedicated to providing practical knowledge in the prevention and treatment of infections in specific immunocompromised patients, including those with cancer, transplant recipients, HIV infection, and autoimmune disorders. Emphasis is placed on diagnostic evaluation, antimicrobial selection that includes consideration of the threat of antimicrobial-resistant pathogens, and immunotherapy tailored to specific patients. Finally, dedicated chapters on stem cell transplantation for patients with primary immunodeficiencies, adoptive cellular immunotherapy, and gene therapy will provide readers with insight into these rapidly evolving and cutting edge therapies.Management of Infections in the Immunocompromised Host is a valuable resource for infectious diseases specialists, immunologists, oncologists, hematologists, general physicians, students, researchers, and all other working with immunocompromised patients.

Encyclopedia of Medical Immunology

Encyclopedia of Medical Immunology Book
Author : Ian R. Mackay,Noel R. Rose
Publisher : Unknown
Release : 2019
ISBN : 9781461492092
Language : En, Es, Fr & De

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Book Description :

Offering a broad appeal to microbiologists, immunologists, and infectious disease specialists, this four volume encyclopedia covers all autoimmune, tropical, and infectious diseases. Emphasis will also be placed on genetics, physiology, metabolism, pathogenesis and applied microbiology. Under the leadership of some of the most world renowned names in the field, the encyclopedia will bring together an outstanding collection of contributions by top scientists in a variety of fields. Volumes 1-3: Diseases will be divided by the 11 main sections of the body, namely Integumentary, Skeletal, Respiratory, Digestive, Urinary, and Reproductive. For some of the autoimmune disease, more then one system will be involved but the delineation serves to broadly break down the diseases into systems. Volume 4 will cover the vaccines for said diseases and future prospects will be offered by leaders in industry and academia. Volume 4 will also be broken down into all the body systems, as in the other two volumes. For each vaccine, for each disease, and in each system the following will be included: • A list of the vaccines currently available along with a list of the companies that manufacture them • Molecular Immunology of the Vaccine • Type of Immunity involved in protection • Mode of Vaccination for each vaccine; repeated boosters and length of immunological memory • Commercial production of vaccines • Storage of vaccines • Standardization and Control of Vaccines • WHO programs and World-Wide Disease Eradication Programs based upon Vaccines.

Sex Hormones and Immunity to Infection

Sex Hormones and Immunity to Infection Book
Author : Sabra L. Klein,Craig Roberts
Publisher : Springer Science & Business Media
Release : 2009-10-22
ISBN : 9783642021558
Language : En, Es, Fr & De

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Book Description :

Why sex matters Among human and nonhuman animals, the prevalence and intensity of infection typically is higher in males than females and may reflect differences in exposure as well as susceptibility to pathogens. Elevated immunity among females is a double-edged sword in which it is beneficial against infectious diseases but is detrimental in terms of increased development of autoimmune diseases. The present book critically reviews the evolutionary origin and the functional mechanisms responsible for sexual dimorphism in response to infection. It emphasizes the value of examining responses in both males and females to improve our understanding about host-pathogen interactions in both sexes. The contributors are experts in their specific disciplines which range from microbiology and immunology to genetics, pathology, and evolutionary biology. The book aims at bringing insight to the treatment and management of infectious diseases; it delineates areas where knowledge is lacking and highlights future avenues of research.

Autoantibodies

Autoantibodies Book
Author : Yehuda Shoenfeld,Pier Luigi Meroni,M. Eric Gershwin
Publisher : Newnes
Release : 2013-11-26
ISBN : 0444593772
Language : En, Es, Fr & De

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Book Description :

Autoimmune diseases are characterized by the occurrence of antibodies reacting with self-constituents of the body. The fully updated third edition of Autoantibodies is an in-depth review of the main autoantibodies identified up to now, with particular emphasis on those that display a diagnostic or prognostic clinical value. The new edition covers recent scientific advances, diagnostic techniques, and therapeutic technologies. Each chapter is focused on a single family of autoantibodies. This important reference contains historical notes, definitions, origins and sources of antigens recognized genetic associations, mediated pathogenic mechanisms, methods of detection, as well as clinical utility (disease prevalence and association, diagnostic value, sensitivity and specificity, prognostic value). This is an ideal reference for anyone involved in the field of autoimmune diseases. Presents all known, important autoantibodies in a single source, focusing on the antibodies needed for autoimmune disorder diagnosis Includes clinical applications for each autoantibody along with general information Organized by disease and disorder type, by autoantibody family, and completely cross-referenced