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Individualized Drug Therapy For Patients

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Individualized Drug Therapy for Patients

Individualized Drug Therapy for Patients Book
Author : Roger W Jelliffe,Michael Neely
Publisher : Academic Press
Release : 2016-11-15
ISBN : 0128033495
Language : En, Es, Fr & De

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Book Description :

Individualized Drug Therapy for Patients: Basic Foundations, Relevant Software and Clinical Applications focuses on quantitative approaches that maximize the precision with which dosage regimens of potentially toxic drugs can hit a desired therapeutic goal. This book highlights the best methods that enable individualized drug therapy and provides specific examples on how to incorporate these approaches using software that has been developed for this purpose. The book discusses where individualized therapy is currently and offers insights to the future. Edited by Roger Jelliffe, MD and Michael Neely, MD, renowned authorities in individualized drug therapy, and with chapters written by international experts, this book provides clinical pharmacologists, pharmacists, and physicians with a valuable and practical resource that takes drug therapy away from a memorized ritual to a thoughtful quantitative process aimed at optimizing therapy for each individual patient. Uses pharmacokinetic approaches as the tools with which therapy is individualized Provides examples using specific software that illustrate how best to apply these approaches and to make sense of the more sophisticated mathematical foundations upon which this book is based Incorporates clinical cases throughout to illustrate the real-world benefits of using these approaches Focuses on quantitative approaches that maximize the precision with which dosage regimens of potentially toxic drugs can hit a desired therapeutic goal

Clinical Pharmacokinetics

Clinical Pharmacokinetics Book
Author : Joseph Wartak
Publisher : Praeger Publishers
Release : 1983-01-01
ISBN : 9780030626524
Language : En, Es, Fr & De

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Book Description :

Download Clinical Pharmacokinetics book written by Joseph Wartak, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Applied Pharmacokinetics Pharmacodynamics

Applied Pharmacokinetics   Pharmacodynamics Book
Author : Michael E. Burton
Publisher : Lippincott Williams & Wilkins
Release : 2006
ISBN : 9780781744317
Language : En, Es, Fr & De

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Book Description :

The definitive advanced-level clinical pharmacokinetics text is now in its Fourth Edition, with new emphasis on the relationship between pharmacokinetics and pharmacodynamics. Written by 70 leading researchers and practitioners, this book is a rigorous yet practical text on the application of pharmacokinetic methods, pharmacodynamic principles, and pharmacotherapeutic data for optimal, individualized drug therapy. This edition includes case studies that apply concepts to actual patient problems. New chapters cover tacrolimus, mycophenolic acid, sirolimus, antipsychotics, and critical evaluation of therapeutic drug monitoring methods. Other new features include more drawings and reference tables and an appendix on outcome studies with therapeutic drug monitoring.

Variability in Response to Antihypertensive Drug Therapy

Variability in Response to Antihypertensive Drug Therapy Book
Author : Anonim
Publisher : Unknown
Release : 2014
ISBN : 9789462594029
Language : En, Es, Fr & De

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Book Description :

Download Variability in Response to Antihypertensive Drug Therapy book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Journal of the National Medical Association

Journal of the National Medical Association Book
Author : Anonim
Publisher : Unknown
Release : 2002
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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Abrams Clinical Drug Therapy

Abrams  Clinical Drug Therapy Book
Author : Geralyn Frandsen,Sandra Smith Pennington
Publisher : Wolters Kluwer Law & Business
Release : 2020-10
ISBN : 9781975160173
Language : En, Es, Fr & De

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Book Description :

Trusted by generations of nursing students and practicing nurses alike for its clear organization and approachable presentation, Abrams' Clinical Drug Therapy, Twelfth Edition continues a long tradition of guiding students and instructors through the practice of safe and effective medication administration. Expert pharmacology educators and clinicians explain the "why" behind each nursing action and emphasize individualized nursing care and drug therapy to promote optimal outcomes in every care setting. Filled with case studies, concept maps, and other engaging features, this updated edition establishes a solid foundation for understanding clinical drug therapy, reflects the latest evidence-based standards for administration, and details how to prevent or minimize adverse effects. A robust suite of online resources complements the text to guide students to success throughout their courses, NCLEX® exams, and nursing careers. Nursing Process Concept Maps simplify guidelines for visual learners. QSEN Safety Alerts help students ensure compliance with standards for safe practice. Clinical Application Case Studies reflect the SBAR model and challenge students to apply concepts to realistic patient care scenarios. Clinical Reasoning Case Studies test students' critical thinking and clinical judgment. Unfolding Patient Stories, written by the National League for Nursing, foster valuable reflection on commonly encountered clinical scenarios. Concept Mastery Alerts clarify commonly misunderstood concepts based on Lippincott® PrepU adaptive learning data. Learning Objectives highlight essential chapter content. Black Box Warnings alert students to life-threatening adverse effects identified by the FDA. Evidence-Based Practice boxes familiarize students with the latest clinical research and its relevance for effective nursing practice. NCLEX® Success sections reflect the latest NCLEX test plan and ready students for success on the exam. Drugs at a Glance tables summarize the routes and dosage ranges (for adults and children), as well as the pregnancy category, for each drug in the class. Drug Interactions and Herb and Dietary Interactions boxes highlight the risk of interactions as well as increased or decreased drug effects when drugs are combined with other medications, food, or herbal supplements. Patient Teaching Guidelines list specific information to improve patient and family education. Key Terms define important terminology for understanding chapter content.

Drug Benefits and Risks

Drug Benefits and Risks Book
Author : Chris J. van Boxtel,Budiono Santoso,I. Ralph Edwards
Publisher : John Wiley & Sons
Release : 2001-11-28
ISBN : 9780471899273
Language : En, Es, Fr & De

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Book Description :

This is an inclusive reference exploring the scientific basis and practice of drug therapy. The key concept is to look at the balance between the benefits and risks of drugs but in this context also the social impact which drugs have in modern societies is highlighted. Taking an evidence-based approach to the problem, the practice of clinical pharmacology and pharmacotherapy in the developing as well as the developed world is examined. For this purpose the book * Covers general clinical pharmacology, pharmacology of various drug groups and the treatments specific to various diseases * Gives guidance on how doctors should act so that drugs can be used effectively and safely * Encourages the rational use of drugs in society This book brings together a large amount of excellent content that will be invaluable for anyone working within, or associated with, the field of clinical pharmacology and pharmacotherapy - undergraduates, postgraduates, regulatory authorities and the pharmaceutical industry.

Biopharmaceutical Drug Design and Development

Biopharmaceutical Drug Design and Development Book
Author : Susanna Wu-Pong,Yon Rojanasakul
Publisher : Springer Science & Business Media
Release : 2010-01-11
ISBN : 1597455326
Language : En, Es, Fr & De

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Book Description :

This book provides a comprehensive examination of the newest biopharmaceutical drugs. Among the drugs discussed are ones in the categories of monoclonal antibodies for in-vivo use, cytokines, growth factors, enzymes, immunomodulators, thrombolytics, and immonotherapies including vaccines. Additionally, the volume examines new and emerging technologies, and contains a review of the Human Genome Project.

Abrams Clinical Drug Therapy International Edition

Abrams  Clinical Drug Therapy  International Edition Book
Author : Geralyn Frandsen
Publisher : Unknown
Release : 2017-11
ISBN : 9781496365316
Language : En, Es, Fr & De

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Book Description :

Download Abrams Clinical Drug Therapy International Edition book written by Geralyn Frandsen, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Pharmacogenetics and Individualized Therapy

Pharmacogenetics and Individualized Therapy Book
Author : Anke-Hilse Maitland-van der Zee,Ann K. Daly
Publisher : John Wiley & Sons
Release : 2012-04-02
ISBN : 1118116488
Language : En, Es, Fr & De

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Book Description :

This resource provides thorough coverage of pharmacogenetics and its impact on pharmaceuticals, therapeutics, and clinical practice. It opens with the basics of pharmacogenetics, including drug disposition and pharmacodynamics. The following section moves into specific disease areas, including cardiovascular, psychiatry, cancer, asthma/COPD, adverse drug reactions, transplantation, inflammatory bowel disease, and pain medication. Clinical practice and ethical issues make up the third section, with the fourth devoted to technologies like genotyping, genomics, and proteomics. In the fifth part, chapters discuss the impact of key regulatory issues on the pharmaceutical industry.

Clinical Trials of Drugs and Biopharmaceuticals

Clinical Trials of Drugs and Biopharmaceuticals Book
Author : Chi-Jen Lee,Lucia H. Lee,Christopher L. Wu,Benjamin R. Lee,Mei-Ling Chen
Publisher : CRC Press
Release : 2005-09-19
ISBN : 1420039148
Language : En, Es, Fr & De

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Book Description :

The pharmaceutical industry is on the verge of an exciting and challenging century. Advances in pharmaceutical sciences have dramatically changed the processes of discovery and development of new therapeutic drugs and, in turn, resulted in an extraordinary increase in the potential prophylactic and therapeutic interventions. In this atmosphere, an

Advances in Cardiopulmonary Rehabilitation

Advances in Cardiopulmonary Rehabilitation Book
Author : Jean Jobin,Francois Maltais,Pierre LeBlanc
Publisher : Human Kinetics
Release : 2000
ISBN : 9780736003124
Language : En, Es, Fr & De

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Book Description :

In recent years, research has demonstrated that exercise programs can benefit patients with chronic obstructive pulmonary disease (COPD) and patients with congestive heart failure (CHF). Yet many physicians do not refer such patients to any kind of exercise or rehabilitation program. Advances in Cardiopulmonary Rehabilitation examines the history of how pulmonary and cardiac diseases have been treated and shows how that history tends to constrain contemporary thinking in spite of significant advances in treatment. -Why do only a small percentage of eligible patients enroll in cardiopulmonary rehab programs? -What percentage of patients can be helped, and in what ways? -What are the most cost-efficient allocations of scarce financial resources for cardiac and pulmonary patients? The contributors to this book address these questions and provide answers that are challenging and often quite surprising. The First Québec International Symposium on Cardiopulmonary Rehabilitation was held in Québec City in May 1999, bringing together experts from around the world to discuss every aspect of cardiopulmonary rehabilitation. Editors Jean Jobin, PhD, François Maltais, MD, Pierre LeBlanc, MD, and Clermont Simard, PhD, selected the most groundbreaking papers presented at the conference and expanded on several of them for this reference. The book offers review articles and some original research. The editors' comprehensive introduction and conclusion provide an invaluable synthesis and overview of current understanding and future directions for cardiopulmonary rehabilitation. Whether you are a clinician, a researcher, an educator, or an administrator, Advances in Cardiopulmonary Rehabilitation will give you -an understanding of how trends in cardiopulmonary rehabilitation during the past century affect current practices, -hard data that will help you determine the best practices in cardiopulmonary rehabilitation, -data that will enhance your ability to treat patients you may have assumed were untreatable, and -a clear overview of recent research in cardiopulmonary rehabilitation. Part I explains not only what has happened in the past, but how past and current practices may influence the future. Part II offers thorough scientific reviews of pharmacological treatment for CHF and COPD. Part III, offers the clearest discussion available--accompanied by extensive data--of how to decide who should be referred and who should not. Part IV discusses peripheral muscle limitations and dysfunction. Part V addresses risks and benefits for different kinds of patients, home exercise programs for COPD patients, interactions between exercise and left ventricular remodeling, and effects of temperature extremes on people with cardiovascular disease. Part VI explains how cardiopulmonary illness, as well as various rehab approaches, affect a patient's psychosocial health, and examines economic evaluations of rehab programs. Part VII deals with factors that affect quality of life and how to measure outcomes of treatment in terms of quality of life. Finally, part VIII looks to the future--what is likely to happen in the areas of technology, pharmacology, psychosocial factors, and self-help care. This well-researched volume (more than 2,200 bibliographical references) is essential for anyone who deals with cardiac or pulmonary patients. This is the only single volume that probes the scientific, clinical, economic, and even psychosocial frontiers of cardiac and pulmonary rehabilitation.

Translational ADMET Drug for Therapy

Translational ADMET Drug for Therapy Book
Author : Souzan B. Yanni
Publisher : John Wiley & Sons
Release : 2015-10-19
ISBN : 1118838270
Language : En, Es, Fr & De

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Book Description :

Serving as a practical handbook about ADMET for drug therapy, this book presents effective technologies, methods, applications, data interpretation, and decision-making tactics for pharmaceutical and preclinical scientists. Chapters cover case studies and in vivo, in vitro, and computational tools for drug discovery and development, with new translational approaches to clinical drug investigations in various human populations. Illustrates ADME properties, from bedside to bench and bench to bedside, for the design of safe and effective medicine in human populations Provides examples that demonstrate the integration of in vitro, in vivo, and in silico data to address human PKPD and TKTD and help determine the proper therapeutic dosage Presents successful tools for evaluating drugs and covers current translational ADMET with regulatory guidelines Offers a hands-on manual for researchers and scientists to design and execute in vitro, in silico, preclinical, and clinical studies Includes discussion of IND / NDA filing and drug labeling to support drug registration and approval

Individualized Medicine

Individualized Medicine Book
Author : Tobias Fischer,Martin Langanke,Paul Marschall,Susanne Michl
Publisher : Springer
Release : 2015-01-16
ISBN : 331911719X
Language : En, Es, Fr & De

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Book Description :

In 2009 the University Medicine Greifswald launched the “Greifswald Approach to Individualized Medicine” (GANI_MED) to implement biomarker-based individualized diagnostic and therapeutic strategies in clinical settings. Individualized Medicine (IM) has led not only to controversies about its potentials, but also about its societal, ethical and health economic implications. This anthology focusses on these areas and includes – next to clinical examples illustrating how the integrated analysis of biomarkers leads to significant improvement of therapeutic outcomes for a subgroup of patients – chapters about the definition, history and epistemology of IM. Additionally there is a focus on conceptual philosophical questions as well as challenges for applied research ethics (informed consent process, the IT-based consent management and the handling of incidental findings). Finally it pays attention to health economic aspects. The possibilities of IM to initiate a paradigm shift in the German health care provision are investigated. Furthermore, it is asked whether the G-DRG system is ready for the implementation of such approaches into clinical routine.

Abrams Clinical Drug Therapy Lippincott photo atlas of medication administration

Abrams  Clinical Drug Therapy  Lippincott photo atlas of medication administration Book
Author : Anonim
Publisher : Unknown
Release : 2015
ISBN : 9781496347961
Language : En, Es, Fr & De

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Book Description :

Abrams' Clinical Drug Therapy has a long tradition of promoting safe and effective medication administration. Highly praised for its organized and readable presentation, this texts explains the "why" behind each nursing action, and emphasizes individualized nursing care and drug therapy.

Pharmacogenetics and Individualized Therapy

Pharmacogenetics and Individualized Therapy Book
Author : Anke-Hilse Maitland-van der Zee,Ann K. Daly
Publisher : John Wiley & Sons
Release : 2012-05-08
ISBN : 047043354X
Language : En, Es, Fr & De

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Book Description :

This resource provides thorough coverage of pharmacogenetics and its impact on pharmaceuticals, therapeutics, and clinical practice. It opens with the basics of pharmacogenetics, including drug disposition and pharmacodynamics. The following section moves into specific disease areas, including cardiovascular, psychiatry, cancer, asthma/COPD, adverse drug reactions, transplantation, inflammatory bowel disease, and pain medication. Clinical practice and ethical issues make up the third section, with the fourth devoted to technologies like genotyping, genomics, and proteomics. In the fifth part, chapters discuss the impact of key regulatory issues on the pharmaceutical industry.

The Future of Pharmaceutical Product Development and Research

The Future of Pharmaceutical Product Development and Research Book
Author : Anonim
Publisher : Academic Press
Release : 2020-09-02
ISBN : 0128144556
Language : En, Es, Fr & De

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Book Description :

The Future of Pharmaceutical Product Development and Research examines the latest developments in the pharmaceutical sciences, also highlighting key developments, research and future opportunities. Written by experts in the field, this volume in the Advances in Pharmaceutical Product Development and Research series deepens our understanding of the product development phase of drug discovery and drug development. Each chapter covers fundamental principles, advanced methodologies and technologies employed by pharmaceutical scientists, researchers and the pharmaceutical industry. The book focuses on excipients, radiopharmaceuticals, and how manufacturing should be conducted in an environment that follows Good Manufacturing Practice (GMP) guidelines. Researchers and students will find this book to be a comprehensive resource for those working in, and studying, pharmaceuticals, cosmetics, biotechnology, foods and related industries. Provides an overview of practical information for clinical trials Outlines how to ensure an environment that follows Good Manufacturing Practice (GMP) Examines recent developments and suggests future directions for drug production methods and techniques

Handbook of Institutional Pharmacy Practice

Handbook of Institutional Pharmacy Practice Book
Author : Thomas R. Brown
Publisher : ASHP
Release : 2006
ISBN : 158528114X
Language : En, Es, Fr & De

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Book Description :

This comprehensive text provides fundamental information on a broad spectrum of essential topics in health-system pharmacy practice. From an overview of health delivery systems and hospital pharmacy through various practice settings such as home care, long term care, hospice and palliative care, ambulatory care, and managed care this text focuses on various elements important to health-system pharmacies. The Handbook of Institutional Pharmacy Practice is the first step in developing a career in pharmacy and provides opportunities for study in career enhancement. New chapters included in the FOURTH EDITION: Integrity of the Drug Supply Overview of the History of Hospital Pharmacy in the United States Interprofessional Teams/Collaborative Practice Models Development, Implementation and Monitoring Therapeutic Plans and Evidence-Based Medicine

Quantitative Pharmacology and Individualized Therapy Strategies in Development of Therapeutic Proteins for Immune Mediated Inflammatory Diseases

Quantitative Pharmacology and Individualized Therapy Strategies in Development of Therapeutic Proteins for Immune Mediated Inflammatory Diseases Book
Author : Honghui Zhou,Diane R. Mould
Publisher : Wiley
Release : 2019-03-19
ISBN : 111928919X
Language : En, Es, Fr & De

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Book Description :

Thorough Overview Identifies and Addresses Critical Gaps in the Treatment of Several Chronic Diseases With increasing numbers of patients suffering from Immune-Mediated Inflammatory Diseases (IMIDs), and with the increasing reliance on biopharmaceuticals to treat them, it is imperative that researchers and medical practitioners have a thorough understanding of the absorption, distribution, metabolism and excretion (ADME) of therapeutic proteins as well as translational pharmacokinetic/pharmacodynamic (PK/PD) modeling for them. This comprehensive volume answers that need to be addressed. Featuring eighteen chapters from world-renowned experts and opinion leaders in pharmacology, translational medicine and immunology, editors Honghui Zhou and Diane Mould have curated a much-needed collection of research on the advanced applications of pharmacometrics and systems pharmacology to the development of biotherapeutics and individualized treatment strategies for the treatment of IMIDs. Authors discuss the pathophysiology of autoimmune diseases in addition to both theoretical and practical aspects of quantitative pharmacology for therapeutic proteins, current translational medicine research methodologies and novel thinking in treatment paradigm strategies for IMIDs. Other notable features include: • Contributions from well-known authors representing leading academic research centers, specialized contract research organizations and pharmaceutical industries whose pipelines include therapeutic proteins • Chapters on a wide range of topics (e.g., pathophysiology of autoimmune diseases, biomarkers in ulcerative colitis, model-based meta-analysis use in the development of therapeutic proteins) • Case studies of applying quantitative pharmacology approaches to guiding therapeutic protein drug development in IMIDs such as psoriasis, inflammatory bowel disease, multiple sclerosis and lupus Zhou and Mould’s timely contribution to the critical study of biopharmaceuticals is a valuable resource for any academic and industry researcher working in pharmacokinetics, pharmacology, biochemistry, or biotechnology as well as the many clinicians seeking the safest and most effective treatments for patients dealing with chronic immune disorders.

Science Based Bioethics

Science Based Bioethics Book
Author : John Loike,Ruth Fischbach
Publisher : Lulu.com
Release : 2014-01
ISBN : 1304768589
Language : En, Es, Fr & De

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Book Description :

This book has two primary aims, to analyze how advancing scientific discoveries uncover or elicit bioethical concerns and challenges and to provide the essential scientific background and bioethical information that allows scientists, healthcare professionals and clinical researchers to better comprehend, appreciate and address the complex bioethical dilemmas that our society confronts.