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In Vivo Models To Study Angiogenesis

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In Vivo Models to Study Angiogenesis

In Vivo Models to Study Angiogenesis Book
Author : Domenico Ribatti
Publisher : Academic Press
Release : 2017-08-18
ISBN : 0128140216
Language : En, Es, Fr & De

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Book Description :

In Vivo Models to Study Angiogenesis provides the latest information and an overview of the most common assays for studying angiogenesis in vivo. Under physiological conditions, angiogenesis is tightly controlled, whereas increased production of angiogenic stimuli and/or reduced production of angiogenic inhibitors leads to abnormal neovascularization, such as occurs in cancer, chronic inflammatory disease, diabetic retinopathy, macular degeneration and cardiovascular disorders. Several genetic and epigenetic mechanisms are involved in the early development of the vascular system. This book presents the latest information from the extensive literature and research available. Evidence is now emerging that blood vessels themselves have the ability to provide instructive regulatory signals to surrounding non-vascular target cells during organ development. Thus, endothelial cell signaling is currently believed to promote fundamental cues for cell fate specification, embryo patterning, organ differentiation and postnatal tissue remodeling. Provides information on the most common assays to study angiogenesis in vivo Presents an ideal reference for those interested in angiogenesis as a normal and vital process in growth and development Covers wound healing, the formation of granulation tissue, and the transition of tumors from benign to malignant

Angiogenesis

Angiogenesis Book
Author : William D. Figg,Judah Folkman
Publisher : Springer Science & Business Media
Release : 2008-05-24
ISBN : 0387715185
Language : En, Es, Fr & De

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Book Description :

Dr. Judah Folkman is considered the "father of angiogenesis." Because of Folkman's discovery and research, the possibilities of angiogenic therapy have broadened beyond cancer to many noncancerous diseases. Angiogenesis: An Integrative Approach from Science to Medicine is a comprehensive, concise summary of tumor angiogenesis. It is an up-to-date and authoritative reference for the angiogenesis field as it relates to oncology. This book represents the first collection in a volume of which Folkman is co-editor. Folkman has authored nearly 400 original papers and more than 100 book chapters.

Clinically Applied Microcirculation Research

Clinically Applied Microcirculation Research Book
Author : John H. Barker,Gary L. Anderson,Michael D. Menger
Publisher : Routledge
Release : 2019-06-04
ISBN : 0429523432
Language : En, Es, Fr & De

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Book Description :

First published in 1995: Clinically Applied Microcirculation Research combines state-of-the-art microcirculation technology with present and potential applications in clinical medicine. This comprehensive guide unites the expertise of clinicians and basic researchers from around the world. Many of the chapters are authored by scientist/physician teams. The book provides a broad overview of how microcirculation is involved in clinical research. This is also a valuable reference source for both the history of and latest developments in microcirculation research.

In Vivo Models of Inflammation

In Vivo Models of Inflammation Book
Author : Lisa A. Marshall,Douglas W. Morgan
Publisher : Birkhäuser
Release : 2013-11-11
ISBN : 3034877757
Language : En, Es, Fr & De

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Book Description :

The purpose of this volume in the series Progress in Inflammation Research is to pro vide the biomedical researcher with a description of the state of the art of the devel opment and use of animal models of diseases with components of inflammation. Par ticularly highlighted are those models which can serve as in vivo correlates of diseases most commonly targeted for therapeutic intervention. The format is designed with the laboratory in mind; thus it provides detailed descriptions of the methodologies and uses of the most significant models. Also, new approaches to the development of future models in selected therapeutic areas have been highlighted. While emphasis is on the newest models, new information broadening our understanding of several well-known models of proven clinical utility is included. In addition, we have pro vided coverage of transgenic and gene transfer technologies which will undoubtedly serve as tools for many future approaches. Provocative comments on the cutting edge and future directions are meant to stimulate new thinking. Of course, it is important to recognize that the experimental use of animals for human benefit carries with it a solemn responsibility for the welfare of these animals. The reader is referred to the section on current regulations governing animal use which addresses this concern. To fulfill our purpose, the content is organized according to therapeutic areas with the associated models arranged in subcategories of each therapeutic area.

The Textbook of Angiogenesis and Lymphangiogenesis Methods and Applications

The Textbook of Angiogenesis and Lymphangiogenesis  Methods and Applications Book
Author : Enrique Zudaire,Frank Cuttitta
Publisher : Springer Science & Business Media
Release : 2012-11-29
ISBN : 9400745818
Language : En, Es, Fr & De

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Book Description :

Angiogenesis and lymphangiogenesis have become attractive targets for drug therapy because of their key roles in a broad spectrum of pathological disease states ranging from macular degeneration to tumor growth and metastasis. A substantial increase in the research effort over the past decade has deepened our understanding of the basic mechanisms underlying angiogenesis and lymphangiogenesis, promoting the development of promising therapeutics for the clinical management of vascular-related diseases. These extraordinary advancements have been built upon a vast array of diverse analytical techniques developed globally throughout the field. Over the years, these methods have evolved to suit the specific needs of different researchers and experimental scenarios, resulting in a myriad of technical variants of basic assay approaches. "The Textbook of Angiogenesis and Lymphangiogenesis: Methods and Applications" is an up-to-date comprehensive textbook on angiogenesis and lymphangiogenesis techniques and applications. This volume is designed to embody the collective works of experts in the clinical as well as the basic research arenas who have significantly contributed to the development and application of techniques in all areas of angiogenesis and lymphangiogenesis. Each chapter introduces and discusses one or a group of closely related techniques and convey step-by-step protocol information and detailed technical guidance to the reader. Emphasis has been placed on explanatory illustrations, critical technical steps as well as divulging information on the benefits and caveats of specific practices related to the methods discussed. This manual is intended to serve as a written guide for both newcomers and established professionals in the field.

Vascular Morphogenesis In Vivo In Vitro In Mente

Vascular Morphogenesis  In Vivo  In Vitro  In Mente Book
Author : Charles Little,Vladimir Mironov,Helen Sage
Publisher : Springer Science & Business Media
Release : 1998-09-29
ISBN : 9780817639204
Language : En, Es, Fr & De

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Book Description :

This book is the concerted effort of an outstanding cast of multidisciplinary contributors who attempt to convey the current level of understanding of vascular morphogenesis. Detailed essays enhance the practical value of the volume for specialists and beginners alike. The book is highly recommended for researchers interested in how vessels are built, both in nature and via modeling. Students in a broad array of fields - biology, medicine, biomedical engineering, biophysics - will find this volume inspiring. The book also serves as an introduction to the field for computer specialists seeking new and exciting applications to computer modeling.

Angiogenesis In Vivo Systems

Angiogenesis  In Vivo Systems Book
Author : N.A
Publisher : Academic Press
Release : 2009-02-12
ISBN : 9780080921662
Language : En, Es, Fr & De

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Book Description :

Understanding how angiogenesis "works" and how to control it will have massive implications on the management, treatments, and ultimately the prevention of many common (and not so common) diseases. Angiogenesis is the growth of new blood vessels and is an important natural process in the body. A healthy body maintains a perfect balance of angiogenesis modulators. In many serious disease states, however, the body loses control over angiogenesis. Diseases that are angiogenesis-dependent result when blood vessels either grow excessively or insufficiently. * Tried-and-tested techniques written by researchers that developed them, used them, and brought them to fruition * Provides the "builder's manual" for essential techniques--a one-stop shop that eliminates needless searching among untested techniques * Includes step-by-step methods for understanding the cell and molecular basis of wound healing, vascular integrin signaling, mechanical signaling in blood vessels, and vascular proteomics

Angiogenesis In Vivo Systems

Angiogenesis  In Vivo Systems Book
Author : David A. Cheresh
Publisher : Academic Press
Release : 2009-02-12
ISBN : 9780080921655
Language : En, Es, Fr & De

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Book Description :

Angiogenesis is the growth of new blood vessels and is an important natural process in the body. A healthy body maintains a perfect balance of angiogenesis modulators. In many serious disease states, however, the body loses control over angiogenesis. Diseases that are angiogenesis-dependent result when blood vessels either grow excessively or insufficiently. Understanding how angiogenesis "works" and how to control it, will have massive implications on the management, treatments, and ultimately the prevention of many common (and not so common) diseases. Angiogenesis cuts across virtually every discipline. The Angiogenesis Foundation identified angiogenesis as a "common denominator" in our most serious diseases. Excessive angiogenesis occurs in diseases such as cancer, diabetic blindness, age-related macular degeneration, rheumatoid arthritis, psoriasis, and many other conditions. Insufficient angiogenesis occurs in diseases such as coronary artery disease, stroke, and delayed wound healing. * Tried-and-tested techniques written by researchers that developed them, used them, and brought them to fruition. * Provides the "builder's manual" for essential techniques. This is a one-stop shop that eliminates needless searching among untested techniques. * Includes step-by-step methods for understanding the cell and molecular basis of wound healing, vascular integrin signaling, mechanical signaling in blood vessels, and vascular proteomics

The Chick Embryo Chorioallantoic Membrane in the Study of Angiogenesis and Metastasis

The Chick Embryo Chorioallantoic Membrane in the Study of Angiogenesis and Metastasis Book
Author : Domenico Ribatti
Publisher : Springer Science & Business Media
Release : 2010-01-28
ISBN : 9789048138456
Language : En, Es, Fr & De

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Book Description :

The chick embryo chorioallantoic membrane (CAM) is an extraembryonic membrane which serves as a gas exchange surface and its function is supported by a dense capillary network. Because of its extensive vascularization and easy accessibility, the CAM has been broadly used to study the morpho-functional aspects of the angiogenesis process in vivo and to investigate the efficacy and mechanisms of action of pro-angiogenic and anti-angiogenic natural and synthetic molecules. The CAM is a suitable site for transplanting tissues, which can survive and develop in the CAM by peripheral anastomoses between graft and original CAM vasculature or by new angiogenic vessels grown from the CAM that invade the graft. While the formation of peripheral anastomoses between host and pre-existing donor vessels is the main, and the most common, mechanism involved in the revascularization of embryonic grafts, the growth of CAM-derived vessels into the graft is only stimulated in tumor grafts. The CAM has long been a favored system for the study of tumor angiogenesis and metastasis, because at this stage the chick immunocompetence system is not fully developed and the conditions for rejection have not been established. Tumors remain avascular for 72 h, after which they are penetrated by new blood vessels and begin a phase of rapid growth. Also, delivery of tumor cells onto the CAM allows the fine study of the effects of tumor derived angiogenic growth factors on blood vessel structure and functionality. The CAM may also used to verify the ability to inhibit the growth of capillaries by implanting tumors onto the CAM and by comparing tumor growth and vascularization with or without the administration of an anti-angiogenic molecule. Other studies using the tumor cells/CAM model have focused on the invasion of the chorionic epithelium and the blood vessels by tumor cells. The cells invade the epithelium and the mesenchymal connective tissue below, where they are found in the form of a dense bed of blood vessels, which is a target for intravasation.

Issues in Neurology Research and Practice 2011 Edition

Issues in Neurology Research and Practice  2011 Edition Book
Author : N.A
Publisher : ScholarlyEditions
Release : 2012-01-09
ISBN : 1464963568
Language : En, Es, Fr & De

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Book Description :

Issues in Neurology Research and Practice / 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Neurology Research and Practice. The editors have built Issues in Neurology Research and Practice: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Neurology Research and Practice in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Neurology Research and Practice: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Wound Healing

Wound Healing Book
Author : Luisa A. DiPietro,Aime L. Burns
Publisher : Springer Science & Business Media
Release : 2003
ISBN : 1592593321
Language : En, Es, Fr & De

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Book Description :

Recognized experts in the field offer a compendium of classic and contemporary protocols for those engaged in active lab studies of wound healing in humans and animals. Scientifically informative and clinically relevant, this text is a valuable resource for basic and clinical scientists interested in initiating or expanding their efforts in wound healing research.

Integrin Protocols

Integrin Protocols Book
Author : Anthony Howlett
Publisher : Springer Science & Business Media
Release : 1999
ISBN : 159259249X
Language : En, Es, Fr & De

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Book Description :

In Integrin Protocols, Anthony Howlett and a distinguished panel of experimentalists describe in detail a series of cutting-edge methods for dissecting the role of integrins in biological processes. This wide-ranging collection includes protocols for the analysis of integrin expression-at both the RNA and protein levels-and for elucidating the functional properties of integrins, including those at the cellular level. Each method provides step-by-step instructions for easy reproducibility, along with extensive notes about potential pitfalls, and tips on how to avoid failure. The emphasis is always on the practical steps necessary for experimental success and robust results. Offering powerful tools for understanding how integrins regulate cell growth, differentiation, migration, invasion, angiogenesis, and apoptosis, as well as how abnormalities of integrin expression and function may be implicated in various pathologic conditions, Integrin Protocols constitutes a gold-standard collection of techniques for both new and experienced investigators of the molecular and cellular basis of cardiovascular disease, inflammatory disorders, and cancer.

Angiogenesis in Health and Disease

Angiogenesis in Health and Disease Book
Author : Michael E. Maragoudakis,Pietro M. Gullino,Peter I. Lelkes
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 1461533589
Language : En, Es, Fr & De

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Book Description :

Angiogenesis describes the formation of new blood vessels, which arise as outgrowths from existing vessels. In many physiological processes such as ovulation and wound healing angiogenesis is involved for a relatively short time. Otherwise under normal physiological conditions in the adult organism angiogenesis is an extremely slow process. By contrast in certain disease states such as diabetic retinopathy, arthritis, chronic inflammation, hemangiomas, etc., angiogenesis persists and contributes to the pathology of these disease states. Some 50 such "angiogenic diseases" have been described where angiogeneSiS is involved. Also in tumor growth and metastasis angiogenesis is an essential process and precedes neoplastic transformation. Hence, angiogenesis could become an important diagnostic tool and a target for developing therapeutic agents. This book contains the proceedings of the NATO Advanced Study Institute on "Angiogenesis in Health and Disease" held in Porto Hydra, Greece, from June 16-27, 1991. This meeting was a comprehensive review of endothelial cell biology and endothelial cell phenotypic and functional heterogeneity in relation to angiogenesis under physiological and pathological conditions. Numerous in vitro and in vivo models were presented, which are used to study angiogenesis at the molecular and cellular levels and to evaluate chemical compounds or naturally occuring substances for their effect on angiogenesis. The presentations and discussions at this meeting provided an opportunity for the basic science and the clinical disciplines to meet, exchange information and provide future research directions for many investigators engaged in the study of angiogenesis.

Angiogenesis Assays

Angiogenesis Assays Book
Author : Carolyn A. Staton,Claire Lewis,Roy Bicknell
Publisher : John Wiley & Sons
Release : 2007-01-11
ISBN : 047002934X
Language : En, Es, Fr & De

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Book Description :

Angiogenesis, the development of new blood vessels from the existing vasculature, is essential for physiological growth and over 18,000 research articles have been published describing the role of angiogenesis in over 70 different diseases, including cancer, diabetic retinopathy, rheumatoid arthritis and psoriasis. One of the most important technical challenges in such studies has been finding suitable methods for assessing the effects of regulators of eh angiogenic response. While increasing numbers of angiogenesis assays are being described both in vitro and in vivo, it is often still necessary to use a combination of assays to identify the cellular and molecular events in angiogenesis and the full range of effects of a given test protein. Although the endothelial cell - its migration, proliferation, differentiation and structural rearrangement - is central to the angiogenic process, it is not the only cell type involved. the supporting cells, the extracellular matrix and the circulating blood with its cellular and humoral components also contribute. In this book, experts in the use of a diverse range of assays outline key components of these and give a critical appraisal of their strengths and weaknesses. Examples include assays for the proliferation, migration and differentiation of endothelial cells in vitro, vessel outgrowth from organ cultures, assessment of endothelial and mural cell interactions, and such in vivo assays as the chick chorioallantoic membrane, zebrafish, corneal, chamber and tumour angiogenesis models. These are followed by a critical analysis of the biological end-points currently being used in clinical trials to assess the clinical efficacy of anti-angiogenic drugs, which leads into a discussion of the direction future studies should take. This valuable book is of interest to research scientists currently working on angiogenesis in both the academic community and in the biotechnology and pharmaceutical industries. Relevant disciplines include cell and molecular biology, oncology, cardiovascular research, biotechnology, pharmacology, pathology and physiology.

Cornea and External Eye Disease

Cornea and External Eye Disease Book
Author : Thomas Reinhard,Frank Larkin,D. F. P. Larkin
Publisher : Springer Science & Business Media
Release : 2006
ISBN : 9783540226000
Language : En, Es, Fr & De

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Book Description :

This volume from the Essentials in Ophthalmology series presents recent developments in the diagnosis and treatment of corneal disease. Its intention is not to replace the relevant textbooks, but to serve as a bridge between the primary and tertiary literature. This well-structured volume covers the following main topics: Confocal microscopy of the cornea.- Treatment of adenoviral corneal opacities.- Conservative treatment of severe surface disorders.- Amniotic membrane transplantation.- Limbal stem cell transplantation.- Techniques in penetrating keratoplasty.- Deep anterior lamellar keratoplasty.- Corneal allograft rejection.- Infective complications following LASIK. All topics have direct clinical importance and will not only keep ophthalmologists up-to-date, but will inform them how to treat their cornea patients with optimal (or best possible) diagnostic and therapeutic procedures.

Methods in Endothelial Cell Biology

Methods in Endothelial Cell Biology Book
Author : Hellmut G. Augustin
Publisher : Springer Science & Business Media
Release : 2004-07-20
ISBN : 9783540213970
Language : En, Es, Fr & De

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Book Description :

Endothelial cell biology has developed into a vibrant discipline and has become a critical instrument to study several disease processes on the cellular and molecular level. It is now widely recognized that dysfunctions of normal endothelial cell homeostasis are involved in some of the most important human diseases, including ischemic heart diseases, hypertension, atherosclerosis, tumors, diabetes, arthritis, and inflammation. Further, the increasing importance and recognition of the field of vascular biology in general requires in vitro and in vivo techniques in order to address the complex questions. Methods in Endothelial Cell Biology is a comprehensive practical "how-to"-guide summarizing the most relevant established techniques as well as a number of new emerging techniques. Easy-to-follow reliable protocols provide a useful lab bench resource for the experienced researcher and newcomer to the field.

Rheumatoid Arthritis E Book

Rheumatoid Arthritis E Book Book
Author : Marc C. Hochberg,Alan J. Silman,Josef S. Smolen,Michael E. Weinblatt,Michael H. Weisman
Publisher : Elsevier Health Sciences
Release : 2008-11-07
ISBN : 0323071023
Language : En, Es, Fr & De

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Book Description :

First Prize, Orthopaedics and Rheumatology, BMA Awards 2009 This state-of-the-art reference provides current insights into the etiology, diagnosis and management of rheumatoid arthritis. Leading international authorities in RA examine all of the latest scientific and clinical developments in understanding and managing this challenging disease, including new concepts in pathogenesis, epidemiology, risk factors, imaging, clinical outcomes and treatment. It’s the guidance you need to offer optimal care to your patients with rheumatoid arthritis. Presents the work of leading international experts in rheumatoid arthritis for guidance you can trust. Provides the very latest understanding of the pathogenesis of rheumatoid arthritis, including molecular pathways/mechanisms, and genetic and environmental factors that instigate and drive the disease. Includes comprehensive coverage of clinical features of rheumatoid arthritis including articular, peri-articular and extra-articular manifestations, comorbidities, and outcome measures—disease activity, joint assessment, imaging, and more—for expert diagnosis and monitoring of disease progression. Examines evidence-based treatment options—including traditional and biologic DMARDs and combination therapies—as well as promising therapies on the horizon, placing up-to-date guidance on disease modifying or disease controlling agents at your fingertips.

Tumor Suppressor Genes

Tumor Suppressor Genes Book
Author : Wafik S. El-Deiry
Publisher : Springer Science & Business Media
Release : 2003
ISBN : 1592593291
Language : En, Es, Fr & De

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Book Description :

Powerful new tools are now available to discover and understand tumor suppressor genes (TSGs) and the biochemical mechanisms by which they control cancer development and progression. In Tumor Suppressor Genes, Volume 2: Regulation, Function, and Medicinal Applications, leading physician scientists and researchers explore the cell biology and biochemical function of the tumor suppressor genes, as well as their physiological role in vivo. The authors detail the physical methods-NMR, microarray approaches, posttranslational structure analysis, analysis of regulation at the gene expression and protein signaling levels-used to understand the function of tumor suppressor genes. In vivo approaches discussed include studies in yeast, Drosophila, mice, and human tumors. The authors also discuss how one ultimately derives a "tumor progression model," the drug discovery process, and the weaknesses of cancers that allow drugs to selectively kill them. Other aspects reviewed include screening strategies, targeting the blood supply of tumors, and the replacement of defective cancer genes to achieve a therapeutic effect. The companion volume of this set, Tumor Suppressor Genes, Volume 1: Pathways and Isolation Strategies, covers all known tumor suppressor genes, describing their cellular signaling pathways, how they were discovered, how they can be analyzed, and how they can be optimally used in cancer therapeutics Comprehensive and authoritative, the two volumes of Tumor Suppressor Genes provide an unparalleled compilation of key data on all known tumor suppressor pathways and a treasury of techniques for their discovery, analysis, and uses in cancer therapeutics.

Mathematical Biology II

Mathematical Biology II Book
Author : James D. Murray
Publisher : Springer Science & Business Media
Release : 2011-02-15
ISBN : 0387952284
Language : En, Es, Fr & De

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Book Description :

This richly illustrated third edition provides a thorough training in practical mathematical biology and shows how exciting mathematical challenges can arise from a genuinely interdisciplinary involvement with the biosciences. It has been extensively updated and extended to cover much of the growth of mathematical biology. From the reviews: ""This book, a classical text in mathematical biology, cleverly combines mathematical tools with subject area sciences."--SHORT BOOK REVIEWS