Skip to main content

In Vivo Analysis Of Trk Receptor Signalling In The Mouse Nervous System

In Order to Read Online or Download In Vivo Analysis Of Trk Receptor Signalling In The Mouse Nervous System Full eBooks in PDF, EPUB, Tuebl and Mobi you need to create a Free account. Get any books you like and read everywhere you want. Fast Download Speed ~ Commercial & Ad Free. We cannot guarantee that every book is in the library!

In Vivo Analysis of Trk Receptor Signalling in the Mouse Nervous System

In Vivo Analysis of Trk Receptor Signalling in the Mouse Nervous System Book
Author : Juan Antonio Postigo
Publisher : Unknown
Release : 2001
ISBN : 0987650XXX
Language : En, Es, Fr & De

GET BOOK

Book Description :

Download In Vivo Analysis of Trk Receptor Signalling in the Mouse Nervous System book written by Juan Antonio Postigo, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Life and Death in the Nervous System

Life and Death in the Nervous System Book
Author : C. F. Ibanez,T. Hokfelt,L. Olson,K. Fuxe,H. Jornvall,D. Ottoson
Publisher : Elsevier Health Sciences
Release : 1995-12-22
ISBN : 1483287955
Language : En, Es, Fr & De

GET BOOK

Book Description :

Life and Death in the Nervous System

Encyclopedia of Neuroscience Volume 1

Encyclopedia of Neuroscience  Volume 1 Book
Author : Larry R. Squire
Publisher : Academic Press
Release : 2009-06-12
ISBN : 0080963935
Language : En, Es, Fr & De

GET BOOK

Book Description :

The Encyclopedia of the Neuroscience explores all areas of the discipline in its focused entries on a wide variety of topics in neurology, neurosurgery, psychiatry and other related areas of neuroscience. Each article is written by an expert in that specific domain and peer reviewed by the advisory board before acceptance into the encyclopedia. Each article contains a glossary, introduction, a reference section, and cross-references to other related encyclopedia articles. Written at a level suitable for university undergraduates, the breadth and depth of coverage will appeal beyond undergraduates to professionals and academics in related fields.

Handbook of the Neuroscience of Aging

Handbook of the Neuroscience of Aging Book
Author : Patrick R. Hof,Charles V. Mobbs
Publisher : Academic Press
Release : 2010-05-22
ISBN : 9780080954059
Language : En, Es, Fr & De

GET BOOK

Book Description :

A single volume of 85 articles, the Handbook of the Neurobiology of Aging is an authoritative selection of relevant chapters from the Encyclopedia of Neuroscience, the most comprehensive source of neuroscience information assembled to date (AP Oct 2008). The study of neural aging is a central topic in neuroscience, neuropsychology and gerontology. Some well-known age-related neurological diseases include Parkinson's and Alzheimer's, but even more common are problems of aging which are not due to disease but to more subtle impairments in neurobiological systems, including impairments in vision, memory loss, muscle weakening, and loss of reproductive functions, changes in body weight, and sleeplessness. As the average age of our society increases, diseases of aging become more common and conditions associated with aging need more attention by doctors and researchers. This book offers an overview of topics related to neurobiological impairments which are related to the aging brain and nervous system. Coverage ranges from animal models to human imaging, fundamentals of age-related neural changes and pathological neurodegeneration, and offers an overview of structural and functional changes at the molecular, systems, and cognitive levels. Key pathologies such as memory disorders, Alzheimer's, dementia, Down syndrome, Parkinson's, and stroke are discussed, as are cutting edge interventions such as cell replacement therapy and deep brain stimulation. There is no other current single-volume reference with such a comprehensive coverage and depth. Authors selected are the internationally renowned experts for the particular topics on which they write, and the volume is richly illustrated with over 100 color figures. A collection of articles reviewing our fundamental knowledge of neural aging, the book provides an essential, affordable reference for scientists in all areas of Neuroscience, Neuropsychology and Gerontology. * The most comprehensive source of up-to-date data on the neurobiology of aging, review articles cover: normal, sensory and cognitive aging; neuroendocrine, structural and molecular factors; and fully address both patholgy and intervention * Chapters represent an authoritative selection of relevant material from the most comprehensive source of information about neuroscience ever assembled, (Encyclopedia of Neuroscience), synthesizing information otherwise dispersed across a number of journal articles and book chapters, and saving researchers the time consuming process of finding and integrating this information themselves * Offering outstanding scholarship, each chapter is written by an expert in the topic area and over 20% of chapters feature international contributors, (representing 11 countries) * Provides more fully vetted expert knowledge than any existing work with broad appeal for the US, UK and Europe, accurately crediting the contributions to research in those regions * Fully explores various pathologies associated with the aging brain (Alzheimer's, dementia, Parkinson's, memory disorders, stroke, Down's syndrome, etc.) * Coverage of disorders and key interventions makes the volume relevant to clinicians as well as researchers * Heavily illustrated with over 100 color figures

Developmental Neurobiology

Developmental Neurobiology Book
Author : Greg Lemke
Publisher : Academic Press
Release : 2010-05-22
ISBN : 9780123751676
Language : En, Es, Fr & De

GET BOOK

Book Description :

Developmental Neuroscience is one of the six core disciplines in Neuroscience, and yet no single volume, non-textbook reference exists on the market that provides researchers with more in-depth, high-level information on developmental neurobiology. Currently, anyone interested in the field at a higher level must sift through review articles published frequently and the more specific handbooks that focus on aspects of development rather than the field as a whole. This reference is the first of its kind to fill this need. It pulls together the relevant articles on the topic from the 10-volume Encyclopedia of Neuroscience (Academic Press, 2008) and serves as an affordable and immediate resource for scientists, postdocs, graduate students with an interest beyond the basic textbook materials on the subject. The first and only comprehensive, single-volume reference for developmental neuroscience that goes beyond the basic textbook information The 93 chapters cover topics ranging from cell fate determination, path finding, synapse generation, neural stem cells, to neurodegeneration and regeneration, carefully selected from the Encyclopedia of Neuroscience by one of the great developmental neuroscientists, Greg Lemke The best researchers in the field provide their conclusions in the context of the latest experimental results

Patterning and Cell Type Specification in the Developing CNS and PNS

Patterning and Cell Type Specification in the Developing CNS and PNS Book
Author : Anonim
Publisher : Academic Press
Release : 2013-05-06
ISBN : 0123973481
Language : En, Es, Fr & De

GET BOOK

Book Description :

The genetic, molecular, and cellular mechanisms of neural development are essential for understanding evolution and disorders of neural systems. Recent advances in genetic, molecular, and cell biological methods have generated a massive increase in new information, but there is a paucity of comprehensive and up-to-date syntheses, references, and historical perspectives on this important subject. The Comprehensive Developmental Neuroscience series is designed to fill this gap, offering the most thorough coverage of this field on the market today and addressing all aspects of how the nervous system and its components develop. Particular attention is paid to the effects of abnormal development and on new psychiatric/neurological treatments being developed based on our increased understanding of developmental mechanisms. Each volume in the series consists of review style articles that average 15-20pp and feature numerous illustrations and full references. Volume 1 offers 48 high level articles devoted mainly to patterning and cell type specification in the developing central and peripheral nervous systems. Series offers 144 articles for 2904 full color pages addressing ways in which the nervous system and its components develop Features leading experts in various subfields as Section Editors and article Authors All articles peer reviewed by Section Editors to ensure accuracy, thoroughness, and scholarship Volume 1 sections include coverage of mechanisms which: control regional specification, regulate proliferation of neuronal progenitors and control differentiation and survival of specific neuronal subtypes, and controlling development of non-neural cells

Mechanisms of Developmental Neuronal Remodeling in Dorsal Root Ganglia Sensory Neurons

Mechanisms of Developmental Neuronal Remodeling in Dorsal Root Ganglia Sensory Neurons Book
Author : Andres de Leon
Publisher : Unknown
Release : 2021
ISBN : 0987650XXX
Language : En, Es, Fr & De

GET BOOK

Book Description :

"Developmental neuronal cell death and axonal pruning are essential remodeling processes for the proper maturation and function of the nervous system. Dysregulation of developmental neuronal remodeling is associated with neuropsychiatric conditions such as autism and schizophrenia. Reactivation of similar degenerative mechanisms is suspected to contribute to the onset of neurodegenerative diseases. Understanding the mechanisms of degeneration during developmental neuronal remodeling could open new therapeutic strategies for the treatment of pathological neurodegeneration. Because of its accessibility, clear anatomical organization and the possibility to establish simple in vitro culture models, the sensory nervous system constitutes a convenient system for the study of developmental neuronal remodeling. This thesis explores different aspects of developmental neuronal remodelling in dorsal root ganglia (DRG) sensory neurons. Our first study, presented in Chapter 2, investigates the role of the amyloid-precursor protein (APP) in the developmental degeneration of NGF-dependent DRG neurons. Our results indicate that APP genetic deletion delays axonal degeneration and reduces the catastrophic axoplasmic Ca2+ rise triggered by NGF deprivation in vitro. We also observe an increase in the number of sciatic nerve axons in APP-null adult mice in vivo. We found evidence that APP regulates the amount of Ca2+ in the endoplasmic reticulum (ER), the store-operated Ca2+ entry (SOCE), and the mitochondrial membrane potential in DRG neurons. Interestingly, we observed that NGF deprivation triggers a transient increase in phosphorylated APP at threonine 668, a hallmark of APP pro-degenerative roles in other cellular models, and that the induction of this post-translational modification is modulated by TrkA receptor signaling thought the phospholipase C gamma (PLC[gamma]) and protein kinase C (PKC). Taken together, our findings support the hypothesis that APP plays a pro-degenerative role in developmental degeneration of DRG sensory neurons. Our second study presented in Chapter 3 investigates the mechanisms of developmental neuronal remodeling in a population of DRG neurons dependent on BDNF. Our results indicate differences and similarities between the molecular signaling pathways behind NGF and BDNF deprivation-induced degeneration. For instance, we observed that inhibitors of Trk receptors, PKC, protein translation or caspases protect DRG from NGF deprivation but do not protect DRG from BDNF deprivation. Interestingly, degeneration of BDNF-dependent sensory neurons requires BAX and appears to rely on reactive oxygen species generation rather than caspases to induce degeneration. These results highlight the complexity and divergence of mechanisms regulating developmental sensory neuron death. Our last study presented in Chapter 4 explores if local deprivation of trophic support using microfluidic chamber is a suitable model to study the mechanisms of developmental axonal pruning in embryonic DRG neurons. Using microfluidic devices to establish compartmentalized cultures of DRG neurons, we followed the variations of the number of DRG soma and axons over the course of several trophic support protocols: 1) Global NGF supply, 2) Global NGF deprivation or 3) Local NGF deprivation in distal axons. Our results showed that NGF deprivation in distal axons induces a sharp drop in embryonic DRG cell bodies that is not seen in mature neurons or in embryonic neurons not deprived of NGF. Thus, local NGF deprivation in distal axons from developing neurons may not be mimicking just pruning but a mix of cell death and axonal pruning. These results suggest reconsidering whether the use of embryonic DRG neurons in compartmentalized chambers is a reliable way to model axonal pruning in vitro"--

Mouse Models in the Study of Genetic Neurological Disorders

Mouse Models in the Study of Genetic Neurological Disorders Book
Author : Brian Popko
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 146154887X
Language : En, Es, Fr & De

GET BOOK

Book Description :

The number of mouse models that are available for the study of human genetic neurological disorders is large and growing rapidly. Therefore, it was difficult to select the models that were reviewed in this volume. Clearly, there are important models that are not discussed, and perhaps a volume twice this size would have been more appropriate. Moreover, the pace at which new models are being developed and analyzed is rapid. As this volume goes to press, I am sure that additional mouse genes responsible for naturally occurring neurological disorders are being discovered and that many new transgenic and mutant mouse strains are being developed. Therefore, this volume should not be viewed as a comprehensive compendium, but rather as an update of work in progress. It is exhilarating to witness the fast pace at which these models are being established as important tools in the study of basic neuroscience and neurological disorders. It will be even more exciting to see their utilization in the development and testing of therapeutic interventions for these diseases. I would like to thank each of the authors who have contributed to this volume for their time and their expertise. I would also like to thank Drs. Timothy Coetzee and Joshua Corbin for their advice in the selection of the topics covered. I am deeply indebted to Dr. Kunihiko Suzuki, who first approached me with the idea for this volume, for his guidance throughout its preparation.

Neurotrophins and the Neural Crest

Neurotrophins and the Neural Crest Book
Author : Maya Sieber-Blum
Publisher : CRC Press
Release : 1998-06-29
ISBN : 9780849340048
Language : En, Es, Fr & De

GET BOOK

Book Description :

The target of much current research, the neural crest is a transitory tissue of the vertebrate embryo that gives rise to many diverse structures in the adult organism, including the autonomic nervous system, the enteric nervous system, and most primary sensory ganglia, among other cell types and tissues. Reflecting recent investigations, Neurotrophins and the Neural Crest is dedicated to the roles neurotrophins play in neural crest cell differentiation and in the survival of neural crest derivatives. This timely book correlates in vitro data with results obtained from knock-out mice with targeted neurotrophin or receptor deletions, with the goal of determining the fidelity and usefulness of various experimental culture systems. It also covers embryonic expression patterns and functions of neurotrophins and their receptors. Chapters are organized to begin with neural crest-derived tissues as sources for experimental material, including sensory neurons, sympathetic neurons, enteric neurons, melanocytes, and calcitonin-producing cells from the thyroid, and concludes with discussions of the neural crest cells. A broad range of researchers and scientists involved in growth factors, neuroscience, developmental and cell biology, embryology, and many other fields, will find that Neurotrophins and the Neural Crest targets this fast-moving area of research completely and concisely.

Comprehensive Developmental Neuroscience Patterning and Cell Type Specification in the Developing CNS and PNS

Comprehensive Developmental Neuroscience  Patterning and Cell Type Specification in the Developing CNS and PNS Book
Author : A.M. Davies
Publisher : Elsevier Inc. Chapters
Release : 2013-05-06
ISBN : 0128062215
Language : En, Es, Fr & De

GET BOOK

Book Description :

Download Comprehensive Developmental Neuroscience Patterning and Cell Type Specification in the Developing CNS and PNS book written by A.M. Davies, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Molecular and Cellular Biology of Neuroprotection in the CNS

Molecular and Cellular Biology of Neuroprotection in the CNS Book
Author : Christian Alzheimer
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 1461501237
Language : En, Es, Fr & De

GET BOOK

Book Description :

Given the very limited capacity of regeneration in the brain, protecting neurons that are on the brink of death is a major challenge for basic and clinical neuroscience, with implications for a broad spectrum of acute and chronic neurological and psychiatric diseases. This book brings together leading experts from neurobiology, neurophysiology, neuropharmacology, neuroimmunology and clinical neuroscience to highlight the most recent milestones in this rapidly evolving field. The book will serve as a reference for both basic neuroscientists and clinicians interested in an authoritative update on the molecular and cellular biology of neuroprotection and its promises for new therapeutic strategies.

Cumulated Index Medicus

Cumulated Index Medicus Book
Author : Anonim
Publisher : Unknown
Release : 1992
ISBN : 0987650XXX
Language : En, Es, Fr & De

GET BOOK

Book Description :

Download Cumulated Index Medicus book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Receptor Activation by Antigens Cytokines Hormones and Growth Factors

Receptor Activation by Antigens  Cytokines  Hormones  and Growth Factors Book
Author : David Naor
Publisher : Unknown
Release : 1995
ISBN : 0987650XXX
Language : En, Es, Fr & De

GET BOOK

Book Description :

Upon ligand binding, cell-surface receptors transmit activity signals into the cell, activating multiple metabolic and mitogenic pathways. Although the nature of the stimulatory molecules is infinitely varied, the principles involved in propagating the signals are ubiquitous. Thus, such different stimulators as antigens, cytokines, hormones, and growth factors use similar transduction principles, including ligand-induced receptor internalisation of receptor-ligand complexes, activation of G proteins, aligomerisation, increases in Ca2+ uptake, activation of tyrosine kinases or other kinases and phosphatases, protein phosphorylation or dephosphorylation, and the triggering of oncogenes and transcription factors. The signalling molecules interact with each other through universal zippers, such as SH2 and SH3 domains. This volume integrates the work of the most significant contributors to the field in elucidating the mechanisms involved in these signal transduction pathways.

Hormonal Signaling in Biology and Medicine

Hormonal Signaling in Biology and Medicine Book
Author : Gerald Litwack
Publisher : Academic Press
Release : 2019-10-24
ISBN : 0128138157
Language : En, Es, Fr & De

GET BOOK

Book Description :

Hormonal Signaling in Biology and Medicine: Comprehensive Modern Endocrinology covers the endocrine secretions produced by every organ. This extensive collection of knowledge is organized by tissue, addressing how certain hormones are synthesized in multiple tissues, along with their structure, function and pathways, which are very applicable for researchers in drug design who need to focus on a specific step along the pathway. This is a must have reference for researchers in endocrinology and practicing endocrinologists, but it is also ideal for biochemists, pharmacologists, biologists and students. Serves as a valuable desk reference for researchers Provides information on the structure of a given hormone, its receptor(s), and the pathways that become activated Includes extensive citations to the literature that will enable the reader to dig more deeply into the effects of a given hormone

Neurotrophic Factors

Neurotrophic Factors Book
Author : Gary R. Lewin,Bruce D. Carter
Publisher : Springer Science & Business Media
Release : 2014-03-25
ISBN : 3642451063
Language : En, Es, Fr & De

GET BOOK

Book Description :

This book provides critical reviews of the role of neurotrophins and their receptors in a wide variety of diseases including neurodegenerative diseases like Huntington’s syndrome, cognitive function, psychiatric disorders such as clinical depression, Rett syndrome, motoneurone disease, spinal cord injury, pain, metabolic disease and cardiovascular disease. It also contains contributions from leaders in the field dealing with the basic biology, transcriptional and post-translational regulation of the neurotrophins and their receptors. The present book will review all recent areas of progress in the study of neurotrophins and their biological roles.

Degeneration and Regeneration in the Nervous System

Degeneration and Regeneration in the Nervous System Book
Author : Norman Saunders,Katarzyna Dziegielewska
Publisher : CRC Press
Release : 2003-09-02
ISBN : 0203304489
Language : En, Es, Fr & De

GET BOOK

Book Description :

Degeneration and Regeneration in the Nervous System brings together an international team of contributors to produce a series of critical reviews appraising key papers in the field. The pace of research on brain and spinal cord injury quickened considerably in the last ten years and there is much that is new and important that is covered in this book. However, there is still a long way to go before our knowledge will explain fully why the central nervous system has such a limited capacity for regeneration, and before experimental solutions can be applied to the patient. With emphasis on actual and therapeutic importance of the work reviewed, Degeneration and Regeneration in the Nervous System is a useful overview for graduate students, their teachers and researchers working in this field.

Molecular Neurobiology of Pain

Molecular Neurobiology of Pain Book
Author : David Borsook
Publisher : International Assn for the Study of Pain
Release : 1997
ISBN : 0987650XXX
Language : En, Es, Fr & De

GET BOOK

Book Description :

Patients may complain of hurting down to the bone, but researchers are finding that in fact pain can go clear down to the molecule. Specialists offer 18 papers from a conference in Boston in October 1996 on recent research and its implications for treatment. They cover development aspects of sensory neurons, the neurobiology of inflammation, nerve injury, receptor and ion channels involved in transmitting pain, and projections for future developments. Among specific topics are afferent pain neurons such as altered spinal connections and changes in transmitter and receptor complement, growth-factor contributions to inflammation, and cloning genes for opioid receptors and sodium channels. Annotation copyrighted by Book News, Inc., Portland, OR

Development of Auditory and Vestibular Systems 3 Molecular Development of the Inner Ear

Development of Auditory and Vestibular Systems 3  Molecular Development of the Inner Ear Book
Author : Raymond Romand,Isabel Varela-Nieto
Publisher : Elsevier
Release : 2003-12-15
ISBN : 9780080490915
Language : En, Es, Fr & De

GET BOOK

Book Description :

Thanks to advances in genetics and genomics, research on inner ear development has flourished. Better approaches and experimental models have shed light on the function of a variety of vertebrate genes and their related proteins. This latest volume of Current Topics in Developmental Biology delves into this new research to show how the discovery of more genes involved in the development of the inner ear leads to the generation of new models that examine a wealth of issues -- from the origins of human deafness to the roles of genes during inner ear induction, development and differentiation. The wide variety of experimental approaches will help readers to understand the broad range of issues related to inner ear morphogenesis and other concepts from complementary areas of investigation. This state-of-the-art overview will be essential reading for researchers, clinicians and students alike. * Scores of high-quality, full- color figures * Detailed schemes on the structure and timing of ear development * Current Topics in Developmental Biology is the longest-running forum for contemporary issues in developmental biology

Development of the Nervous System

Development of the Nervous System Book
Author : Dan H. Sanes,Thomas A. Reh,William A. Harris
Publisher : Academic Press
Release : 2011-01-25
ISBN : 9780080923208
Language : En, Es, Fr & De

GET BOOK

Book Description :

Development of the Nervous System presents a broad and basic treatment of the established and evolving principles of neural development as exemplified by key experiments and observations from past and recent times. The text is organized ontogenically. It begins with the emergence of the neural primordium and takes a chapter-by-chapter approach in succeeding events in neural development: patterning and growth of the nervous system, neuronal determination, axonal navigation and targeting, neuron survival and death, synapse formation and developmental plasticity. Finally, in the last chapter, with the construction phase nearing completion, we examine the emergence of behavior. This new edition reflects the complete modernization of the field that has been achieved through the intensive application of molecular, genetic, and cell biological approaches. It is richly illustrated with color photographs and original drawings. Combined with the clear and concise writing, the illustrations make this a book that is well suited to students approaching this intriguing field for the first time. Features Thorough survey of the field of neural development Concise but complete, suitable for a one semester course on upper level undergraduate or graduate level Focus on fundamental principles of organogenesis in the nervous system Integrates information from a variety of model systems, relating them to human nervous system development, including disorders of development Systematically develops knowledge from the description of key experiments and results Organized ontologically Carefully edited to be presented in one voice New edition thoroughly updated and revised to include major new findings All figures in full color, updated and revised Specific attention on revising the chapter on cognitive and behavioral development to provide a foundation and outlook towards those very fast moving areas Instructor website with figure bank and test questions Benefits The only thorough textbook of Developmental Neuroscience on the market Carefully structured and edited to map onto the syllabus of most developmental neuroscience courses Priced to be affordable for undergraduates even in addition to broader textbooks Carefully constructed instructor's website Specifically designed to make teaching of complicated subjects easy and fun for instructors and students alike