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In Vitro Toxicology

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In Vitro Toxicology

In Vitro Toxicology Book
Author : Alok Dhawan,Seok (Soga) Kwon
Publisher : Academic Press
Release : 2017-11-13
ISBN : 0128047712
Language : En, Es, Fr & De

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Book Description :

In Vitro Toxicology details the protocols and methods of in vitro testing, highlighting the usefulness of models, methods and the cost-effectiveness and reproducibility of such methodologies. The current approaches and strategies required to develop an easy, reliable, validated and high throughput system for use in alternative animal models to circumvent in vivo testing are discussed in detail. The book also includes chapters on the principles involved in the general selection and use of models that address safety concerns, regulatory acceptance and the current understandings and strategies for the identification of biomarkers in toxicity testing. Furthermore, principles involved in the general selection and use of models that address the issues of safety concerns and regulatory acceptance of these models are discussed, making the book beneficial to students, scientists, and regulators working in toxicology, as well as those in the field of chemicals and the safety assessment of novel materials. Discusses new techniques and protocols in a clear and concise manner includes examinations of nanotoxicity, genotoxicity and carcinogenicity Explains practical laboratory methods and the theories behind in vitro testing

In Vitro Toxicity Testing Protocols

In Vitro Toxicity Testing Protocols Book
Author : Sheila O’Hare,Christopher K. Atterwill
Publisher : Humana Press
Release : 2013-08-23
ISBN : 9781489940827
Language : En, Es, Fr & De

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Book Description :

In vitro toxicology is one of the most rapidly expanding areas of biological research today. It is generally conceded that this is a result of pressure from the public for safer products and environmental conditions and, in these recessionary times, pressure from company accountants, who often perceive in vitro experimentation as a cheaper option than lawsuits, fines, and expensive remediation. Toxicologists themselves form one group whose vigor and influence on the evolution of in vitro toxicology is often underestimated. Many toxicologists have for some time been unhappy with the quantity (often a result of unnecessary duplication), the reliability, and the ethical circumstances of much animal experimentation. It is hoped that the present book, In Vitro Toxicity Testing Protocols, will play some part in enabling and encouraging the more widespread use of in vitro techniques. Since in vitro toxicity testing methodology is evolving at such a rapid rate, this book can of necessity provide only a "snapshot" of the major techniques in use at the present time. As with the other publications in Humana Press' Methods in Molecular Biology series, the aim has been to supply information on the fundamental requirements for the establishment of new techniques within working laboratories and to describe a variety of basic in vitro methodologies. Certain of the techniques detailed here could more accurately be described as ex vivo rather than truly in vitro. No apology is made for the inclusion of these techniques.

In Vitro Toxicology Second Edition

In Vitro Toxicology  Second Edition Book
Author : Shayne C. Gad
Publisher : CRC Press
Release : 2000-11-02
ISBN : 1560327693
Language : En, Es, Fr & De

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Book Description :

Toxicology has made tremendous strides in the sophistication of the models used to identify and understand the mechanisms of agents that can harm or kill humand and other higher organisms. Non-animals or in vitro models started to gain significant use in the 1960s. As a result of the increased concern over animal welfare, economic factors, and the need for greater sensitivity and understanding of mechanisms, interest in in vitro^n models has risen. This volume demonstrates that there now exists a broad range of in vitro models for use in either identifying or understanding most forms of toxicity. The availability of in vitro models spans both the full range of endpoints (irritation, sensitization, lethality, mutagenicity, and devlopmental toxicity) and the full spectrum of target organ systems (skin, eye, heart, liver, kidney, nervous system, etc.). Chapters are devoted to each of these speciality areas from a perspective of presenting the principal models and their uses and limitations. Chapters that overview the principles involved in the general selection and use of models, and that address the issues of safety concerns and regulatory acceptance of these methods are also included.

Standard Operating Procedures In Vitro Toxicology

Standard Operating Procedures In Vitro Toxicology Book
Author : I.P. Sword,S.D. Thomson
Publisher : Springer
Release : 2011-10-09
ISBN : 9789400987173
Language : En, Es, Fr & De

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Book Description :

When Volume 1 (Toxicolpgy) in this series of Standard Operating Procedures was pub lished in early 1979, the FDA's Good Laboratory Practice Regulations did not have the force of United States Law, but nevertheless had a substantial impact on the conduct of toxicology in laboratories throughout the world. These Regulations are now in force, and Volume 2 (Pathology) was published later the same year. Our critics have implied that we have attempted to reduce toxicology to the level of the cookery book, or alternatively that we seek to impose our standards on others, In some sinister way ensuring that the IRI code will become the international norm. We dismiss these criticisms as arrant nonsense. The many thousands of volumes already sold worldwide can provide at best a framework for adaptation to suit local laboratory condi tions, and thus speed to GLP compliance those organisations which might otherwise have remained foundering at the starting post. If Volumes 1 and 2 of this series have con tributed anything to the conduct of toxicology it must surely be in those non-English speaking nations which, because of the international nature of pharmaceutical and chemical trading, are required by commercial pressures to be in compliance with a foreign law formulated in unfamiliar terminology and introduced for reasons that are not immediately obvious. Much has happened in the short period of time since Volumes 1 and 2 were published.

In Vitro Toxicology Systems

In Vitro Toxicology Systems Book
Author : Anna Bal-Price,Paul Jennings
Publisher : Humana Press
Release : 2016-09-03
ISBN : 9781493954803
Language : En, Es, Fr & De

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Book Description :

In Vitro Toxicology Systems brings together important issues and considerations needed in order to develop a workable, reliable, integrated testing strategy for the replacement of animals in toxicity testing regimes. This thorough volume includes sections on in vitro models for systemic organ toxicity, neurotoxicity, sensory organs, immunotoxicity and reproductive toxicity and addresses how stem cells may be used going forward. The book also tackles difficult areas of toxicology such as carcinogenicity and nanotoxicology, with additional chapters dedicated to kinetics, metabolism, and in vitro in vivo extrapolation. The book also addresses biological processes such as stress response pathways and mechanistic biomarkers and how these can be uncovered and measured using high content approaches. Reliable and authoritative, In Vitro Toxicology Systems will be of benefit not only to students, scientists and regulators working in the field of chemical safety assessment but also to a wider scientific audience.

Cell Culture Methods for In Vitro Toxicology

Cell Culture Methods for In Vitro Toxicology Book
Author : G. Stacey,Alan Doyle,Margherita Ferro
Publisher : Springer Science & Business Media
Release : 2013-06-29
ISBN : 9401709963
Language : En, Es, Fr & De

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Book Description :

Cell Culture Methods for in vitro Toxicology introduces the reader to a range of techniques involved in the use of in vitro cell culture in toxicological studies. It deals with major cell types studied in the field of toxicology and will be useful for anyone wishing to start work with animal cell cultures or to refresh their knowledge relating to in vitro cell models. Fundamental chapters deal with the general biology of cytotoxicity and cell immortalisation these are key issues for in vitro systems addressing the `3Rs' principle. Up-to-date overviews deal with the use of cells from liver, brain and intestine. In addition, biochemical analysis of cell responses, biotransformation pathways in cells and recombinant approaches to the early detection of cell stress are also covered in detail. Prominent features of in vitro technologies also include regulation, biosafety and standardisation. Dedicated chapters deal with these issues in a practical way in order to lead the reader to the right source of information. This book provides an up-to-date, informative and practical review of cell culture methods for in vitro toxicology. It will be of equal benefit to students and experienced toxicologists with little experience of in vitro cell culture.

In Vitro Toxicology

In Vitro Toxicology Book
Author : Alan M. Goldberg,Marilyn L. Principe
Publisher : Mary Ann Liebert
Release : 1991
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download In Vitro Toxicology book written by Alan M. Goldberg,Marilyn L. Principe, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

In Vitro Toxicology

In Vitro Toxicology Book
Author : Anonim
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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Cellular and Molecular Toxicology and In Vitro Toxicology

Cellular and Molecular Toxicology and In Vitro Toxicology Book
Author : Daniel Acosta
Publisher : CRC Press
Release : 2017-07-28
ISBN : 1351367757
Language : En, Es, Fr & De

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Book Description :

This work concentrates on cellular and molecular toxicity of selected well-known drugs or chemicals on the cardiovascular system. The primary objective is to provide a better understanding of the mechanisms by which xenobiotics are toxic to mammalian tissues and cells. The use of in vitro cellular and tissue systems provides attractive experimental models to assess toxic manifestations of xenobiotics. This work addresses the most recent findings on the cellular and molecular mechanisms of toxicity of several important cardiotoxic agents: doxorubicin, ethanol, cocaine, and the catecholamines. It presents an overview of vascular toxins and their biochemical effects. Included is a summary of in vitro cardiovascular techniques for assessing toxicity of xenobiotics. This publication is important for those in toxicology, tissue culture, pharmacology, in vitro toxicology, developmental biology and related areas.

In Vitro Toxicology

In Vitro Toxicology Book
Author : Alan M. Goldberg
Publisher : Mary Ann Liebert
Release : 1985
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download In Vitro Toxicology book written by Alan M. Goldberg, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Industrial in Vitro Toxicology

Industrial in Vitro Toxicology Book
Author : Industrial In Vitro Toxicology Group
Publisher : Unknown
Release : 1989
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Industrial in Vitro Toxicology book written by Industrial In Vitro Toxicology Group, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Principles of Toxicology Testing Second Edition

Principles of Toxicology Testing  Second Edition Book
Author : Frank A Barile
Publisher : CRC Press
Release : 2013-04-02
ISBN : 1842145282
Language : En, Es, Fr & De

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Book Description :

Nationally, toxicology programs have evolved from a traditional exploration of the chemistry and applied toxicity of chemicals and drugs to a more comprehensive study of toxicology and toxicology testing as independent entities. Consequently, the second edition of Principles of Toxicology Testing starts with basic toxicological principles, including absorption, distribution, metabolism, and elimination of toxins, including chemicals and drugs. The book then continues with animal (in vivo) and in vitro toxicology testing methods associated with toxicological analysis and preclinical drug development. As in the first edition, the book begins with an introduction into the fundamentals of toxicology (Section I) to prepare readers for the subsequent topics and continues through with a discussion of toxicokinetics and human risk assessment. This introductory material is useful in understanding the applications of toxicology testing. Section II describes the fundamental principles of toxicology testing in animals in greater detail. This section describes acute toxicity studies as well as subchronic and chronic studies performed on animals. Special emphasis is placed on study design and determination of classical indicators for acute and chronic testing, such as the LD50. The book examines other short- and long-term animal toxicity testing methodologies, including dermal, ocular, and reproductive toxicity testing. In addition, mutagenicity and carcinogenicity studies are also discussed in separate chapters. Section III introduces and discusses in vitro alternatives to animal toxicology tests. This section emphasizes cell culture methodology and cellular methods for acute systemic toxicity, target organ toxicity, and local toxicity. The contributors present the advantages and disadvantages of alternative methods. They also describe the use of high-throughput screening and its applications, the concepts of standardization and validation of in vitro techniques (especially large, organized validation efforts currently supported by US and EU regulatory agencies), and the theories supporting the development of in vitro methodologies. This second edition is a must-read for undergraduate and graduate toxicology students. Industrial and academic research centers will also find the text useful for establishing a toxicology testing laboratory.

Rapport Sur L tat Et Les Tendances de la Toxicologie in Vitro Et Modifications Des M thodologies Pour R duire L exp rimentation Animale

Rapport Sur L   tat Et Les Tendances de la Toxicologie in Vitro Et Modifications Des M  thodologies Pour R  duire L exp  rimentation Animale Book
Author : J. P. W. Gilman
Publisher : Division de la toxicologie des médicaments, Bureau de recherche sur les médicaments, Santé et bien-être social Canada
Release : 1991
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The primary purposes of toxicological testing are the protection of human health and the safeguarding of the environment from excessive manmade contamination. Responsibility for setting safety standards and monitoring their implementation lies mainly with the federal departments of health, agriculture, and the environment. This report discusses in some detail the state-of-the-art of in vitro toxicology and other trends in alternative toxicological testing that may lead to a reduction in the use of animals for these purposes. It covers both the national and international fields, particularly in pharmaceuticals and biologicals. The toxicological testing of consumer chemicals, agricultural chemicals, and foods is also considered in less detail. The report focuses on Canada and the testing R & D undertaken in this country.

In Vitro Toxicity Testing

In Vitro Toxicity Testing Book
Author : John M. Frazier
Publisher : CRC Press
Release : 1992-01-31
ISBN : 9781439805398
Language : En, Es, Fr & De

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Book Description :

This volume focuses on the potential application of in vitro procedures to identify and quantify the toxicological risk to target organs associated with the use of commerical products and therapeutic drugs.;Revealing how the results of in vitro toxicity testing can be used in safety assessment, In Vitro Toxicity Testing: explores whether existing test methods can accomplish the necessary goals and, if not, what research is needed to make these techniques a practical reality; presents the current status of toxicity testing in the areas of hepatotoxicity, renal toxicity, ocular irritation, and many others; outlines the role of validation in technology transfer from the research laboratory to safety evaluation; examines testing strategies and regulatory acceptance and addresses common concerns about the ultimate utilization of available methods in chemical safety/hazard considerations; and analyzes the perspective of industrial and regulatory agencies on the application of in vitro toxicity testing.;Generously referenced with over 1400 literature citations, In Vitro Toxicity Testing is for academic, industrial, and regulatory toxicologists; applied, molecular, and cell biologists; pharmacologists; animal welfare activists; and graduate students in pharmacology and toxicology courses.

In Vitro Toxicology the Current Status

In Vitro Toxicology   the Current Status Book
Author : Anonim
Publisher : Unknown
Release : 1998
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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In Vitro Methods in Toxicology

In Vitro Methods in Toxicology Book
Author : C. K. Atterwill,C. E. Steele
Publisher : Cambridge University Press
Release : 1987-10-22
ISBN : 9780521326841
Language : En, Es, Fr & De

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Book Description :

The volume brings together the once disparate knowledge of cultural techniques and thus provides an important reference work for industrial and academic toxicologists.

In Vitro Toxicology

In Vitro Toxicology Book
Author : Anonim
Publisher : Unknown
Release : 1988
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download In Vitro Toxicology book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Cellular and Molecular Toxicology and In Vitro Toxicology

Cellular and Molecular Toxicology and In Vitro Toxicology Book
Author : Daniel Acosta
Publisher : CRC Press
Release : 1990-08-22
ISBN : 9780849344213
Language : En, Es, Fr & De

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Book Description :

This work concentrates on cellular and molecular toxicity of selected well-known drugs or chemicals on the cardiovascular system. The primary objective is to provide a better understanding of the mechanisms by which xenobiotics are toxic to mammalian tissues and cells. The use of in vitro cellular and tissue systems provides attractive experimental models to assess toxic manifestations of xenobiotics. This work addresses the most recent findings on the cellular and molecular mechanisms of toxicity of several important cardiotoxic agents: doxorubicin, ethanol, cocaine, and the catecholamines. It presents an overview of vascular toxins and their biochemical effects. Included is a summary of in vitro cardiovascular techniques for assessing toxicity of xenobiotics. This publication is important for those in toxicology, tissue culture, pharmacology, in vitro toxicology, developmental biology and related areas.

The Market for in Vitro Toxicology Testing

The Market for in Vitro Toxicology Testing Book
Author : BCC Research
Publisher : Unknown
Release : 2007-03
ISBN : 9781596232754
Language : En, Es, Fr & De

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Book Description :

Download The Market for in Vitro Toxicology Testing book written by BCC Research, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

High Throughput Screening Methods in Toxicity Testing

High Throughput Screening Methods in Toxicity Testing Book
Author : Pablo Steinberg
Publisher : John Wiley & Sons
Release : 2013-02-26
ISBN : 1118538242
Language : En, Es, Fr & De

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Book Description :

Explores the benefits and limitations of the latesthigh-throughput screening methods With its expert coverage of high-throughput in vitroscreening methods for toxicity testing, this book makes it possiblefor researchers to accelerate and streamline the evaluation andrisk assessment of chemicals and drugs for toxicity. Moreover, itenables them to comply with the latest standards set forth by theU.S. National Research Council's "Toxicity Testing in the 21stCentury: A Vision and Strategy" and the E.U.'s REACH legislation.Readers will discover a variety of state-of-the-science,high-throughput screening methods presented by a group of leadingauthorities in toxicology and toxicity testing. High-Throughput Screening Methods in Toxicity Testing isdivided into five parts: General aspects, including predicting the toxicity potential ofchemicals and drugs via high-throughput bioactivity profiling Assessing different cytotoxicity endpoints Assessing DNA damage and carcinogenesis Assessing reproductive toxicity, cardiotoxicity, andhaematotoxicity Assessing drug metabolism and receptor-related toxicity Each chapter describes method principles and includes detailedinformation about data generation, data analysis, and applicationsin risk assessment. The authors not only enumerate the advantagesof each high-throughput method over comparable conventionalmethods, but also point out the high-throughput method'slimitations and potential pitfalls. In addition, the authorsdescribe current research efforts to make high-throughput toxicityscreening even more cost effective and streamlined. Throughout the book, readers will find plenty of figures andillustrations to help them understand and perform the latesthigh-throughput toxicity screening methods. This book is ideal for toxicologists and other researchers whoneed to implement high-throughput screening methods for toxicitytesting in their laboratories as well as for researchers who needto evaluate the data generated by these methods.