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Improving The Therapeutic Ratio In Head And Neck Cancer

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Improving the Therapeutic Ratio in Head and Neck Cancer

Improving the Therapeutic Ratio in Head and Neck Cancer Book
Author : Anonim
Publisher : Academic Press
Release : 2019-10-04
ISBN : 0128178698
Language : En, Es, Fr & De

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Book Description :

Improving the Therapeutic Ratio in Head and Neck Cancer provides a complete review of current approaches to modulating therapeutic sensitivity in head and neck cancer. It presents a broad background of current approaches and by highlighting the potential for clinical translational, introduces a roadmap for how to move promising preclinical findings into the clinic. The book discusses topics such as immunotherapy and molecularly targeted therapies in head and neck cancer, PI3k/mTOR pathway, autophagy inhibition to sensitize HNC to radiation and chemotherapy, TAM and Eph/Ephrin family proteins and metabolic reprogramming to modulate therapeutic sensitivity. Additionally, it details approaches to improve the response to immunotherapy, and Chk1/2 inhibition in radiation and cetuximab resistance. This book is a valuable source to head and neck cancer researchers and advanced students, and to those studying specific approaches in other model systems and disease sites. Provides key scientific background for clinicians when developing novel clinical trials and important examples for basic scientists of the types of work required to move a concept from the lab to the clinic Presents consistent pathway diagrams in each chapter, thus making it easier to understand complicated pathways Includes chapter summaries of the critical next steps needed to move studies from their current state into practice changing clinical data

Increasing the Therapeutic Ratio of Radiotherapy

Increasing the Therapeutic Ratio of Radiotherapy Book
Author : Philip J. Tofilon,Kevin Camphausen
Publisher : Springer
Release : 2016-11-21
ISBN : 3319408542
Language : En, Es, Fr & De

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Book Description :

Current cancer therapies are focused on three general strategies: modifying intrinsic radiosensitivity via molecular targeting, manipulating microenvironmental factors to enhance tumor susceptibility to radiation, and improving delivery of radiation to critical tumor locations while sparing normal tissues. The goal of this volume is to describe a number of promising approaches corresponding to each strategy. In general, research in radiation oncology tends to be siloed into fundamental biology, physics or treatment delivery. The strategies for improving therapeutic ratio encompassed in this book will involve each of these components of radiation oncology. Thus, they will illustrate the variety of disparate approaches available for potentially improving the efficacy of radiotherapy, which may then stimulate discussion across disciplines and foster further translational investigations. Although a goal of each chapter will be to highlight advances within an approach, of equal importance will be the delineation of barriers to successful clinical application and how to overcome or minimize such impediments. Along these lines, because therapeutic ratio incorporates both tumor and normal tissue radio response, a point of emphasis will be the mechanistic rationale for selectively modifying tumor (sensitization) or normal cells (protection). Finally, whereas the literature is replete with studies describing potential targets/strategies for increasing the therapeutic ratio for radiotherapy, this book will focus on those supported by in vivo data consistent with impending translational application along with those that are already being evaluated in the clinic.

Strategies to Enhance the Therapeutic Ratio of Radiation as a Cancer Treatment

Strategies to Enhance the Therapeutic Ratio of Radiation as a Cancer Treatment Book
Author : Mitchell S. Anscher,Kristoffer Valerie
Publisher : Springer
Release : 2016-10-20
ISBN : 331945594X
Language : En, Es, Fr & De

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Book Description :

This volume will describe recent progress and future directions in radiation oncology and biology research, focusing on strategies designed to improve disease control and reduce the risk of long-term adverse effects on patients. As more and more patients are becoming long-term survivors, this strategy will become increasingly important--in radiation oncology and throughout the field of oncology.

Novel Therapies in Head and Neck Cancer Beyond the Horizon

Novel Therapies in Head and Neck Cancer  Beyond the Horizon Book
Author : Maie A. St. John,No hee Park
Publisher : Academic Press
Release : 2020-06-29
ISBN : 0128209291
Language : En, Es, Fr & De

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Book Description :

Novel Therapies in Head and Neck Cancer: Beyond the Horizon, Volume Twelve, provides a high-level synthesis of the latest treatments and outcomes relating to head and neck cancer. Chemotherapy and immunotherapy for those cancer types are rapidly evolving, and an updated source based on the expertise of internationally renowned researchers is necessary. This book discusses the outcome of recent trials using chemotherapy, novel approaches for HPV+ SCCA, cases in which immunotherapy is more likely to be successful, and precision medicine based on target therapies. Additionally, new approaches for rare diseases in head and neck and novel drug delivery platforms are presented. This book will be a very useful source so that students, scientists and clinicians who can be facile with the data, build on what is known, and continue to offer cutting-edge, validated therapies to all patients. Covers new chemotherapy trials, specifically on HPV and non-HPV related cancer types Discusses the application of immunotherapy to treat rare types of head and neck cancer Presents updated information on targeted therapies, specifically focusing on skin cancer in the region

Modeling for Prediction of Radiation Induced Toxicity to Improve Therapeutic Ratio in the Modern Radiation Therapy Era

Modeling for Prediction of Radiation Induced Toxicity to Improve Therapeutic Ratio in the Modern Radiation Therapy Era Book
Author : Ester Orlandi,Tiziana Rancati,Giuseppe Sanguineti,Claudio Fiorino,Riccardo Valdagni
Publisher : Frontiers Media SA
Release : 2021-07-27
ISBN : 2889710882
Language : En, Es, Fr & De

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Book Description :

Download Modeling for Prediction of Radiation Induced Toxicity to Improve Therapeutic Ratio in the Modern Radiation Therapy Era book written by Ester Orlandi,Tiziana Rancati,Giuseppe Sanguineti,Claudio Fiorino,Riccardo Valdagni, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Basic Radiotherapy Physics and Biology

Basic Radiotherapy Physics and Biology Book
Author : David S. Chang,Foster D. Lasley,Indra J. Das,Marc S. Mendonca,Joseph R. Dynlacht
Publisher : Springer
Release : 2014-09-19
ISBN : 3319068415
Language : En, Es, Fr & De

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Book Description :

This book is a concise and well-illustrated review of the physics and biology of radiation therapy intended for radiation oncology residents, radiation therapists, dosimetrists, and physicists. It presents topics that are included on the Radiation Therapy Physics and Biology examinations and is designed with the intent of presenting information in an easily digestible format with maximum retention in mind. The inclusion of mnemonics, rules of thumb, and reader-friendly illustrations throughout the book help to make difficult concepts easier to grasp. Basic Radiotherapy Physics and Biology is a valuable reference for students and prospective students in every discipline of radiation oncology.

Head and Neck Cancer

Head and Neck Cancer Book
Author : John Frederick Ensley,Silvio Gutkind,John A. Jacobs,Scott Lippman
Publisher : Elsevier
Release : 2003-01-07
ISBN : 0080533841
Language : En, Es, Fr & De

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Book Description :

By detailing experimental and basic research, from premalignancy to fully invasive tumors, this book has wide applicability to all human carcinomas. No other group of human cancers is better positioned for the application of recently developed novel and targeted therapies, and this book uniquely presents the unusual opportunities tumors of the head and neck provide for clinical, translational, and basic science research. Cutting-edge and experimental treatment approaches are presented, along with future strategies and an evaluation of emerging technologies. Presents a multi-disciplinary perspective from authorities in diverse fields Addresses state-of-the art approaches in cancer research as well as other scientific opportunities in this field Provides comprehensive yet easily comprehendible source of information

Intensity Modulated Radiation Therapy for Head and Neck Cancer

Intensity Modulated Radiation Therapy for Head and Neck Cancer Book
Author : K. S. Clifford Chao,Gokhan Ozyigit
Publisher : Lippincott Raven
Release : 2003
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The first clinical book on the hottest topic in radiation oncology, this timely teaching text offers step-by-step guidance in use of IMRT for cancers at each subsite of the head and neck. The book's high-end content gives readers the clinical decision-making expertise and technical proficiency to incorporate this state-of-the-art radiation treatment technique into practice. Unique to this text is the site-specific instruction on target determination and delineation, to ensure adequate treatment of the tumor target while sparing adjacent normal tissue. More than 250 detailed full-color and black-and-white illustrations clarify each step in clinical implementations of head and neck cancer treatment, especially IMRT. The book provides a concise, pertinent overview of the natural course, lymph node spread, diagnostic criteria, and therapeutic options for each head and neck cancer subsite. Numerous tables provide extensive summaries of the IMRT literature. Figures with succinct explanatory text demonstrate the patterns of direct tumor extension and nodal metastasis with which target volumes are determined and delineated. Clinical outcomes for patients treated with IMRT and with conventional techniques are also included.

Non melanoma Skin Cancer of the Head and Neck

Non melanoma Skin Cancer of the Head and Neck Book
Author : Faruque Riffat,Carsten E. Palme,Michael Veness
Publisher : Springer
Release : 2015-09-30
ISBN : 8132224973
Language : En, Es, Fr & De

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Book Description :

Non-melanoma skin cancer is a global public health issue. With an ever-increasing, and ageing, world population coupled with increasing numbers of immunosuppressed individuals the number of patients continues to rise. The head and neck is overwhelmingly the most frequent location for the development of a non-melanoma skin cancer and as such challenges the clinician with its complex anatomy. The importance of maintaining the aesthetics of the face and the function of the anatomy cannot be overstated, yet ultimately it is always the aim of curing a patient with the minimum of morbidity that clinicians strive for. However, the spectrum of presentations and subsequent management varies widely, ranging from patients with the ubiquitous low-risk mid-face basal cell carcinoma to those diagnosed with relatively uncommon but potentially life-threatening high-risk squamous cell carcinomas (e.g. involving metastatic lymph nodes or with perineural invasion present) and Merkel cell carcinomas.

PET CT in Cancer An Interdisciplinary Approach to Individualized Imaging

PET CT in Cancer  An Interdisciplinary Approach to Individualized Imaging Book
Author : Mohsen Beheshti,Werner Langsteger,Alireza Rezaee
Publisher : Elsevier Health Sciences
Release : 2017-05-25
ISBN : 0323496083
Language : En, Es, Fr & De

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Book Description :

Edited, authored, and reviewed by an expert team of oncologists and nuclear physicians/radiologists, this one-of-a-kind title helps you make the most of the critical role PET/CT plays in cancer staging and therapeutic responses to individualized treatments. Drs. Mohsen Beheshti, Werner Langsteger, and Alireza Rezaee place an emphasis on cutting-edge research and evidence-based practice, ensuring that you’re up to date with every aspect of this fast-changing field. For each tumor entity, you’ll find authoritative discussions of background, pathology, common pattern of spread, TNM classification, clinical guidelines, discussion, evidence-based recommendations, key points, and pitfalls. Contains 130 teaching cases with high-quality PET/CT images. Presents clear, practical guidance from multiple experts across subspecialties: nuclear medicine, oncology, oncologic surgery, radiation oncology, and clinical research. Includes separate, comprehensive chapters on head and neck, lung, breast, esophageal/gastric, pancreas/neuroendocrine, colorectal, hepatobiliary, lymphoma, gynecologic, prostate, melanoma, and brain cancers. Features short reviews of clinical aspects of different cancers, primary diagnostic procedures, and recommendations regarding PET/CT from ESMO and NCCN. Helps to reveal positive outcomes or potential deficits or weaknesses in an individual plan of care, allowing for better outcomes in patient care, future cancer research, and application of radiotracers beyond 18F-FDG.

Metronomic Chemotherapy

Metronomic Chemotherapy Book
Author : Guido Bocci,Giulio Francia
Publisher : Springer
Release : 2014-09-04
ISBN : 3662436043
Language : En, Es, Fr & De

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Book Description :

This book analyzes all aspects of metronomic chemotherapy, a new approach involving low-dose, long-term, and frequently administered therapy that has preclinical and clinical activity in various tumors. After an opening section on the pharmacological bases of metronomic chemotherapy, including its antiangiogenic effects and impact on immunity, preclinical studies on various classes of drug are discussed. Clinical applications of metronomic chemotherapy in a wide variety of tumors are then addressed in detail, with description of the results of all published studies. The clinical pharmacology of metronomic chemotherapy is also considered in depth, encompassing pharmacokinetics, pharmacogenetics, pharmacoeconomics, and adverse drug reactions. The book closes by describing the role of this therapy in the veterinarian clinic.

Molecular Targeted Radiosensitizers

Molecular Targeted Radiosensitizers Book
Author : Henning Willers,Iris Eke
Publisher : Springer Nature
Release : 2020-08-10
ISBN : 3030497011
Language : En, Es, Fr & De

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Book Description :

Molecular Targeted Radiosensitizers: Opportunities and Challenges provides the reader with a comprehensive review of key pre-clinical research components required to identify effective radiosensitizing drugs. The book features discussions on the mechanisms and markers of clinical radioresistance, pre-clinical screening of targeted radiosensitizers, 3D radiation biology for studying radiosensitizers, in vivo determinations of local tumor control, genetically engineered mouse models for studying radiosensitizers, targeting the DNA damage response for radiosensitization, targeting tumor metabolism to overcome radioresistance, radiosensitizers in the era of immuno-oncology, and more. Additionally, the book features discussions on high-throughput drug screening, predictive biomarkers, pre-clinical tumor models, and the influence of the tumor microenvironment and the immune system, with a specific focus on the challenges radiation oncologists and medical oncologists currently face in testing radiosensitizers in human cancers. Edited by two acclaimed experts in radiation biology and radiosensitizers, with thirteen chapters contributed by experts, this new volume presents an in-depth look at current developments within a rapidly moving field, with a look at where the field will be heading and providing comprehensive insight into the framework of targeted radiosensitzer development. Essential reading for investigators in cancer research and radiation biology.

Metastases in Head and Neck Cancer

Metastases in Head and Neck Cancer Book
Author : Jochen A. Werner,R. Kim Davis
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 3642187226
Language : En, Es, Fr & De

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Book Description :

-Richly illustrated; 109 illustrations, 57 in color -Cover a wide range of diagnostic and theraputic techniques, i.e. MRI, PET, surgical treatment, radiation therapy

Encyclopedia of Cancer

Encyclopedia of Cancer Book
Author : Anonim
Publisher : Academic Press
Release : 2018-10-12
ISBN : 0128124857
Language : En, Es, Fr & De

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Book Description :

Encyclopedia of Cancer, Third Edition provides a comprehensive, up-to-date overview of the multiple facets of the disease, including research, treatment and societal impact. This new edition comprises 180 contributions from renown experts who present the latest in Mechanisms, Hallmarks of Cancer, Causes of Cancer, Prevention and Control, Diagnosis and Therapy, Pathology and the Genetics of specific Cancers. Readers will find a comprehensive overview of the main areas of oncology, including etiology, mechanisms, prevention, and treatments, from basic science to clinical applications and public health, all set alongside the latest advances and hot topics that have emerged since the previous edition. Topics of interest in the field, including genomics and epigenomics, our understanding of the causes of cancer and the approaches to preventing it (e.g., HPV vaccination, role of obesity and nutrition, molecular markers of environmental exposures), new screening techniques (e.g., low-dose CT for lung cancer) and improvements in the treatment of many cancers (e.g., breast cancer, lung adenocarcinoma) are comprehensively and authoritatively presented. Comprises 180 contributions from renowned experts who present the latest in mechanisms, hallmarks of cancer, causes, prevention and control, diagnosis and therapy, pathology and genetics Presents a comprehensive overview of the main areas of oncology, including etiology, mechanisms, prevention, and treatments, from basic science to clinical applications and public health

High Risk Cutaneous Squamous Cell Carcinoma

High Risk Cutaneous Squamous Cell Carcinoma Book
Author : Chrysalyne D. Schmults
Publisher : Springer
Release : 2016-04-29
ISBN : 3662470810
Language : En, Es, Fr & De

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Book Description :

This book is a cutting-edge resource that provides clinicians with the up-to-date practical knowledge required in order to manage SCC patients optimally. It summarizes newly available information relating to the definition of high-risk SCC, its pathophysiologic underpinnings, and its management. New prognostic information and staging systems are summarized that enable high-risk tumors to be defined more precisely than ever before. Many helpful tips are provided on the practical management of challenging cases, including multiple tumors/field cancerization, high-risk tumors, nodal metastases, and unresectable disease. The authors are all acknowledged experts in the emerging field of high-risk and advanced SCC.​

Critical Issues in Head and Neck Oncology

Critical Issues in Head and Neck Oncology Book
Author : Jan B. Vermorken,Volker Budach,C. René Leemans,Jean-Pascal Machiels,Piero Nicolai,Brian O’Sullivan
Publisher : Springer Nature
Release : 2021-06-02
ISBN : 3030632342
Language : En, Es, Fr & De

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Book Description :

This open access book discusses the most current issues in head and neck cancer with a focus on current trends such as biomarkers, precision medicine and immunotherapy. New approaches in the diagnosis such as liquid biopsies and imaging biomarkers to predict radiotherapy toxicity as well as approaches in the surgical management of head and neck cancers are discussed. The book discusses medical and surgical approaches in both primary, recurrent and metastatic disease and also covers approaches for rare head neck cancers. Readers will learn about the latest drug developments and epidemiological aspects in cancers ranging from Head and Neck Squamous Cell Cancer to Nasopharynx cancer. Edited by a team of world leaders in Head and Neck Cancer, this volume serves as an easy reference to the head and neck oncology practitioner and provides a contemporary overview for specialists the field. The chapters are based on the latest data presented at the 7th Trends in Head and Neck Oncology Conference and reflect the most up-to-date information in the field.

Carbon Ion Radiotherapy

Carbon Ion Radiotherapy Book
Author : Hirohiko Tsujii,Tadashi Kamada,Toshiyuki Shirai,Koji Noda,Hiroshi Tsuji,Kumiko Karasawa
Publisher : Springer Science & Business Media
Release : 2013-12-25
ISBN : 4431544577
Language : En, Es, Fr & De

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Book Description :

This book serves as a practical guide for the use of carbon ions in cancer radiotherapy. On the basis of clinical experience with more than 7,000 patients with various types of tumors treated over a period of nearly 20 years at the National Institute of Radiological Sciences, step-by-step procedures and technological development of this modality are highlighted. The book is divided into two sections, the first covering the underlying principles of physics and biology, and the second section is a systematic review by tumor site, concentrating on the role of therapeutic techniques and the pitfalls in treatment planning. Readers will learn of the superior outcomes obtained with carbon-ion therapy for various types of tumors in terms of local control and toxicities. It is essential to understand that the carbon-ion beam is like a two-edged sword: unless it is used properly, it can increase the risk of severe injury to critical organs. In early series of dose-escalation studies, some patients experienced serious adverse effects such as skin ulcers, pneumonitis, intestinal ulcers, and bone necrosis, for which salvage surgery or hospitalization was required. To preclude such detrimental results, the adequacy of therapeutic techniques and dose fractionations was carefully examined in each case. In this way, significant improvements in treatment results have been achieved and major toxicities are no longer observed. With that knowledge, experts in relevant fields expand upon techniques for treatment delivery at each anatomical site, covering indications and optimal treatment planning. With its practical focus, this book will benefit radiation oncologists, medical physicists, medical dosimetrists, radiation therapists, and senior nurses whose work involves radiation therapy, as well as medical oncologists and others who are interested in radiation therapy.

Carcinomas of the Head and Neck

Carcinomas of the Head and Neck Book
Author : Charlotte Jacobs
Publisher : Springer Science & Business Media
Release : 1990-07-31
ISBN : 9780792306689
Language : En, Es, Fr & De

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Book Description :

It was not too many years ago that the role of chemotherapy for head and neck cancer consisted of single-agent methotrexate for selected patients with recurrent disease. In the past decade, multiple new agents, high-dose chemotherapy, combinations, and intra-arterial approaches have been used for the patient with recurrent disease. Wheeler critically assesses the current status of these approaches. When oncologists began testing chemotherapy in the combined modality approach, trials consisted of induction chemotherapy and use of single agents as radiosensitizers. Although a great deal has been learned from these trials, benefit in terms of survival has been marginal. Even more promising may be the concomitant use of combination chemo therapy and radiation. Taylor describes the encouraging results as well as the potential. Induction chemotherapy may have a second important goal in addition to improving curability-it could be used for organ preservation. Dimery et al., present the background for this approach in the patient with laryngeal cancer as well as a description of their randomized trial for voice preservation. Head and neck squamous cancers are a heterogeneous group of diseases, and surgeons have long sought parameters that will help predict outcome.

Oral and Maxillofacial Surgery for the Clinician

Oral and Maxillofacial Surgery for the Clinician Book
Author : Krishnamurthy Bonanthaya,Elavenil Panneerselvam,Suvy Manuel,Vinay V. Kumar,Anshul Rai
Publisher : Springer Nature
Release : 2021
ISBN : 9811513465
Language : En, Es, Fr & De

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Book Description :

This book is an open access book with CC BY 4.0 license. This comprehensive open access textbook provides a comprehensive coverage of principles and practice of oral and maxillofacial surgery. With a range of topics starting from routine dentoalveolar surgery to advanced and complex surgical procedures, this volume is a meaningful combination of text and illustrations including clinical photos, radiographs, and videos. It provides guidance on evidence-based practices in context to existing protocols, guidelines and recommendations to help readers deal with most clinical scenarios in their daily surgical work. This multidisciplinary textbook is meant for postgraduate trainees, young practicing oral surgeons and experienced clinicians, as well as those preparing for university and board certification exams. It also aids in decision-making, the implementation of treatment plans and the management of complications that may arise. This book is an initiative of Association of Oral and Maxillofacial Surgeons of India (AOMSI) to its commitment to academic medicine. As part of this commitment, this textbook is in open access to help ensure widest possible dissemination to readers across the world.

Mitigation of Cancer Therapy Side Effects with Light

Mitigation of Cancer Therapy Side Effects with Light Book
Author : Raj Nair,René-Jean Bensadoun
Publisher : Morgan & Claypool Publishers
Release : 2016-11-01
ISBN : 1681741393
Language : En, Es, Fr & De

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Book Description :

'Light' from low level laser therapy, through a process called photobiomodulation (PBM), has been in existence in supportive care in cancer, in particular in the management of oral mucositis (OM) in patients undergoing chemotherapy, radiation therapy and haematopoietic stem cell transplantation. In this book the authors attempt to portray the current status of the supportive care interventions that are possible with PBM using low level laser therapy (LLLT) in patients undergoing cancer treatment for solid tumours, harmatological malignancies, and head and neck cancers.