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Immunomodulatory Biomaterials

Immunomodulatory Biomaterials Book
Author : Stephen F. Badylak,Jennifer Elisseeff
Publisher : Woodhead Publishing
Release : 2021-07-30
ISBN : 0128214562
Language : En, Es, Fr & De

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Book Description :

Biomaterials have existed for millennia as mechanical replacement structures following disease or injury. Biomaterial design has changed markedly from structural support with an “inert immune profile as the primary objective to designs that elicit an integrative local tissue response and a pro-repair immune cell phenotype. Immunomodulatory Biomaterials: Regulating the Immune Response with Biomaterials to Affect Clinical Outcome offers a single, comprehensive reference on biomaterials for modulation of the host response, for materials scientists, tissue engineers and those working in regenerative medicine. This book details methods, materials and strategies designed to regulate the host immune response following surgical implantation and thus facilitate specific local cell infiltration and tissue deposition. There has been a dramatic transformation in our understanding of the role of the immune system, both innate and adaptive; these changes include recognition of the plasticity of immune cells, especially macrophages, cross-talk between the immune system and stem cells, and the necessity for in situ transition between inflammatory and regulatory immune cell phenotypes. The exploitation of these findings and the design and manufacture of new biomaterials is occurring at an astounding pace. There is currently no book directed at the interdisciplinary principles guiding the design, manufacture, testing, and clinical translation of biomaterials that proactively regulate the host tissue immune response. The challenge for academia, industry, and regulatory agencies to encourage innovation while assuring safety and maximizing efficacy has never been greater. Given the highly interdisciplinary requirements for the design, manufacture and use of immunomodulatory biomaterials, this book will prove a useful single resource across disciplines. Holistically covers the design, manufacture, testing, and clinical translation of biomaterials that proactively regulate the host tissue immune response Provides a single reference for understanding and utilizing the host response in biomaterials design An international collaboration of leading researchers in the field offering a novel insight into this fast-growing area

Immunomodulatory Biomaterials to Mitigate Material induced Host Responses

Immunomodulatory Biomaterials to Mitigate Material induced Host Responses Book
Author : Yoon Kyung Kim
Publisher : Unknown
Release : 2013
ISBN : 9781303444975
Language : En, Es, Fr & De

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Book Description :

The foreign body response to biomaterial implants has been a major challenge in translating many medical devices into the clinic. The presence of inflammatory cells around the implanted device prevents its functional interaction with the surrounding tissue, and although some inflammation may be desirable to mediate the healing process, a persistent inflammatory response will eventually lead to device failure. Significant efforts to reduce foreign body response have been largely focused on developing hydrophilic and anti-fouling coating materials, however, simply preventing protein adsorption and immune cell adhesion has only had moderate success at reducing inflammation in vivo. In this thesis, we describe a novel approach to mitigate the foreign body response, whereby materials are designed to mimic host tissue by displaying endogenously expressed immunomodulatory molecules that interact with specific inhibitory receptors expressed on immune cells. More specifically, biomaterial surfaces are coated with the recombinantly produced immunomodulatory molecule, CD200, which interacts with the inhibitory receptor CD200R on myeloid cells, preventing material-induced host response by suppressing activation of infiltrated myeloid cells. In Chapter One, a brief introduction and background information is presented, followed by a description of the production and purification of recombinant CD200 protein from both mammalian cells and bacterial cells in Chapter Two. In Chapter Three, we examine whether immobilization of CD200 onto polystyrene surfaces influences on suppressing the activation of macrophages. We found that CD200 indeed suppresses the release of inflammatory mediators secreted by macrophage cells in vitro, and elicited less inflammation in vivo when compared to uncoated materials after subcutaneous implantation. In Chapter Four, we examine whether CD200 influences tissue regeneration after spinal cord injury. CD200-embedded fibrin gel was implanted to spinal cord injured mice, and the effect of CD200 on inflammation and regenerative process was examined. Lastly, Chapter Five concludes the work performed in this Ph.D. study and presents future directions. This work suggests that coating of endogenously expressed immunomodulatory proteins can be used as a strategy to reduce inflammatory response to biomaterials and may potentially be generalized to implants throughout the body.

Biomaterials and Immune Response

Biomaterials and Immune Response Book
Author : Nihal Engin Vrana
Publisher : CRC Press
Release : 2018-07-20
ISBN : 1351377558
Language : En, Es, Fr & De

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Book Description :

The interactions of the biomaterials with the host immune system is crucial for their functionality. This book aims to provide the reader with a better understanding of the role of the immune system in biomaterial applications. For this end, the book has dedicated chapters for i) explaining immune cells taking part in immune response to biomaterials/immune systems interface; ii) the effect of biomaterial shape, form and physicochemical properties on the response of immune system; iii) biofilm formation on implanted materials as a failure of immune system/biomaterial interactions; iv) tissue-specific effects of immune response and its consequences for tissue engineering and regenerative medicine; v) immune reaction in a clinical context (periodontology). In the field of biomaterials there are significant advances in using immunomodulation techniques to improve the success rates of implantable materials. For better understanding of such techniques it is required to have a full grasp of the biomaterial–immune system interactions. This would greatly enhance the understanding of why the human body reacts to implants in a certain way and how to improve the clinical outcomes by developing immune-instructive biomaterials. Provides keen insight into biomaterial–immune cell interactions Presents an explanation of state-of-the-art methodologies in immunomodulation Offers a concise and simple-to-understand treatment of biomaterial–immune cell interactions for materials scientists in a biology heavy topic Explores a comprehensive overview of biomaterial related complications Provides extensive references at the end of each chapter to enhance study for this very hot research area

Handbook of Biomaterials Biocompatibility

Handbook of Biomaterials Biocompatibility Book
Author : Masoud Mozafari
Publisher : Woodhead Publishing
Release : 2020-06-17
ISBN : 0081029683
Language : En, Es, Fr & De

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Book Description :

Handbook of Biomaterials Biocompatibility is a systematic reference on host response to different biomaterials, taking into account their physical, mechanical and chemical properties. The book reviews recent progress in the design and study of biomaterials biocompatibility, along with current understanding on how to control immune system response. Sections provide the fundamental theories and challenges of biomaterials biocompatibility, the role of different biomaterials physicochemical surface properties on cell responses, cell responses to different physicochemical properties of polymers, ceramics, metals, carbons and nanomaterials, and biomaterials in different tissues, such as the cardiac, nervous system, cartilage and bone. This resource will be suitable for those working in the fields of materials science, regenerative engineering, medicine, medical devices and nanotechnology. Reviews the fundamental theories and challenges of biomaterials biocompatibility, including an overview of the standards and regulations Provides an overview on the cellular and molecular mechanisms involved in host responses to biomaterials Systematically looks at cellular response and tissue response to a wide range of biomaterials, including polymers, metals, ceramics, alloys and nanomaterials

Biomaterial Mediated Control Over Macrophage Behavior for Tissue Regeneration

Biomaterial Mediated Control Over Macrophage Behavior for Tissue Regeneration Book
Author : Claire Elizabeth Witherel
Publisher : Unknown
Release : 2019
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Macrophages, the primary cell of the immune response, and fibroblasts, the major producers of extracellular matrix (ECM), have significant roles in wound healing and the foreign body response to implanted biomaterials. Macrophages are known to exhibit a spectrum of unique phenotypes in response to their environment; M1 macrophages, are associated with increased inflammation and initiating angiogenesis, while M2a macrophages have been associated with anti-inflammatory behavior and extracellular matrix deposition. Temporal control of macrophage phenotype from M1 to M2a has been shown to be critical in normal wound healing. On the other hand, dysregulated macrophage behavior has been associated with detrimental pathologies including chronic wounds and fibrosis. Therefore, the development of immunomodulatory biomaterials that can harness the natural immune response for repair and healing, hold significant promise for future of regenerative medicine. While it's appreciated that macrophages may hold the key to aberrant healing outcomes, it is not well understood how they direct pro-healing outcomes, especially within the context of a biomaterial implant. Therefore, the overall goals of this work were to 1. thoroughly characterize macrophage-biomaterial interactions and macrophage-fibroblast interactions further our understanding of how these cells may influence functional tissue regeneration, and 2. Utilize a model drug-eluting biomaterial to directly assess the role of M2a macrophages in tissue regeneration. To accomplish these goals, I investigated how macrophages change their behavior in response to 'successful', commercially- available wound matrices in vitro. Collectively, these studies showed that four commercially-available wound matrices evaluated pro-inflammatory macrophage behavior (more M1-like) and that direct contact (as opposed to soluble factors) of macrophages with a bioactive (i.e. containing cells and proteins) wound matrix was critical for reducing inflammation in pro-inflammatory macrophages. Next, I investigated the effects of macrophage-secreted signals on fibroblast behavior and matrix formation in vitro and employed model drug-eluting biomaterials to develop an M2a-promoting hydrogel to directly assess the role of M2a macrophages in the foreign body response in vivo. Together, these studies illustrated that M1 and M2a macrophage-derived signals significantly reduced the fiber diameter of fibroblast-derived deposition in vitro relative to other macrophage phenotypes. While clinically relevant macrophage-derived signals (M1+M2a and M1->M2a) returned fibroblast matrix fiber diameter to the in vitro baseline. IL4+IL13-releasing hydrogel resulted in a significant reduction in leukocyte recruitment 21 days relative to the Blank hydrogel control, suggesting an increased presence of other key ECM-producing cells. Alternatively, these results may also imply that IL4+IL13 hydrogels may change the quality and composition of ECM surrounding a biomaterial or at the tissue-biomaterial interface. Interestingly and in contrast to pilot data, the IL4+IL13 hydrogel yielded minimal differences in gene expression and histological outcomes compared the Blank control. Collectively, these preliminary and somewhat inconclusive in vivo results are likely due to technical challenges there were discovered in the in vivo experimental design. A final validation study showed that the IL4+IL13 hydrogels that were originally implanted within the same mouse as the Blank controls were likely releasing enough drug to have an impact on the outcomes of the Blank controls. Preliminary data from the validation study yielded a robust response of the IL4+IL13 hydrogel relative to the Blank control at the Day 3 time point. Future work will focus on elucidating the long-term effects of these IL4+IL13 hydrogels on ECM deposition. This work is critical for understanding how transient control of macrophage behavior is directly linked to tissue repair and regeneration outcomes. Due to the importance of macrophage behavior in all tissues, this project has the potential to translate into a myriad of other fields, especially those in which abnormal inflammation prevent tissue repair or regeneration.

Emerging Trends in Immunomodulatory Nanomaterials Toward Cancer Therapy

Emerging Trends in Immunomodulatory Nanomaterials Toward Cancer Therapy Book
Author : Anubhab Mukherjee,Vijay Sagar Madamsetty,Sudip Mukherjee
Publisher : Morgan & Claypool Publishers
Release : 2021-04-06
ISBN : 1636391052
Language : En, Es, Fr & De

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Book Description :

Recently, immunomodulatory nanomaterials have gained immense attention due to their involvement in the modulation of the body’s immune response to cancer therapy. This book highlights various immunomodulatory nanomaterials (including organic, polymer, inorganic, liposomes, viral, and protein nanoparticles) and their role in cancer therapy. Additionally, the mechanism of immunomodulation is reviewed in detail. Finally, the challenges of these therapies and their future outlook are discussed. We believe this book will be helpful to a broad community including students, researchers, educators, and industrialists.

Adverse Reactions to Biomaterials State of the Art in Biomaterial Risk Assessment Immunomodulation and In Vitro Models for Biomaterial Testing

Adverse Reactions to Biomaterials  State of the Art in Biomaterial Risk Assessment  Immunomodulation and In Vitro Models for Biomaterial Testing Book
Author : Nihal Engin Vrana,Amir M. Ghaemmaghami,Pinar Zorlutuna
Publisher : Frontiers Media SA
Release : 2019-05-15
ISBN : 2889458229
Language : En, Es, Fr & De

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Book Description :

Adverse immune reactions to biomaterials are important bottlenecks for translation of novel biomaterials for clinical use. Moreover, recent advances in highthrough-put biomaterial discovery and synthetic biology, while providing exciting new veues, also significantly increases potential risks related to the in vivo reactions to these new materials. For example, the novel materials might have unintended biological activities due to their natural building blocks. In this perspective, biomaterial field needs i) better understanding of cell/biomaterial interactions at systems level; ii) development of new analysis and testing tools for advanced risk assessment iii) tools and technologies for modulating reactions to biomaterials and iv) advanced in vitro models for understanding and testing of reactions to biomaterials. In the following collection of articles you will find examples of such systems,together with comprehensive reviews of current developments in in vitro model systems. The collection also contains articles that elucidate the immune reaction to biomaterials in vitro and in vitro.

Biomaterials and Immune Response

Biomaterials and Immune Response Book
Author : Nihal Engin Vrana
Publisher : CRC Press
Release : 2018-07-20
ISBN : 1351377566
Language : En, Es, Fr & De

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Book Description :

The interactions of the biomaterials with the host immune system is crucial for their functionality. This book aims to provide the reader with a better understanding of the role of the immune system in biomaterial applications. For this end, the book has dedicated chapters for i) explaining immune cells taking part in immune response to biomaterials/immune systems interface; ii) the effect of biomaterial shape, form and physicochemical properties on the response of immune system; iii) biofilm formation on implanted materials as a failure of immune system/biomaterial interactions; iv) tissue-specific effects of immune response and its consequences for tissue engineering and regenerative medicine; v) immune reaction in a clinical context (periodontology). In the field of biomaterials there are significant advances in using immunomodulation techniques to improve the success rates of implantable materials. For better understanding of such techniques it is required to have a full grasp of the biomaterial–immune system interactions. This would greatly enhance the understanding of why the human body reacts to implants in a certain way and how to improve the clinical outcomes by developing immune-instructive biomaterials. Provides keen insight into biomaterial–immune cell interactions Presents an explanation of state-of-the-art methodologies in immunomodulation Offers a concise and simple-to-understand treatment of biomaterial–immune cell interactions for materials scientists in a biology heavy topic Explores a comprehensive overview of biomaterial related complications Provides extensive references at the end of each chapter to enhance study for this very hot research area

Peptides and Proteins as Biomaterials for Tissue Regeneration and Repair

Peptides and Proteins as Biomaterials for Tissue Regeneration and Repair Book
Author : Mario Barbosa,M Cristina L Martins
Publisher : Woodhead Publishing
Release : 2017-09-25
ISBN : 008100852X
Language : En, Es, Fr & De

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Book Description :

Peptides and Proteins as Biomaterials for Tissue Regeneration and Repair highlights the various important considerations that go into biomaterial development, both in terms of fundamentals and applications. After covering a general introduction to protein and cell interactions with biomaterials, the book discusses proteins in biomaterials that mimic the extracellular matrix (ECM). The properties, fabrication and application of peptide biomaterials and protein-based biomaterials are discussed in addition to in vivo and in vitro studies. This book is a valuable resource for researchers, scientists and advanced students interested in biomaterials science, chemistry, molecular biology and nanotechnology. Presents an all-inclusive and authoritative coverage of the important role which protein and peptides play as biomaterials for tissue regeneration Explores protein and peptides from the fundamentals, to processing and applications Written by an international group of leading biomaterials researchers

Biomaterials Science

Biomaterials Science Book
Author : William R Wagner,Shelly E. Sakiyama-Elbert,Guigen Zhang,Michael J. Yaszemski
Publisher : Academic Press
Release : 2020-05-23
ISBN : 0128161388
Language : En, Es, Fr & De

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Book Description :

The revised edition of the renowned and bestselling title is the most comprehensive single text on all aspects of biomaterials science from principles to applications. Biomaterials Science, fourth edition, provides a balanced, insightful approach to both the learning of the science and technology of biomaterials and acts as the key reference for practitioners who are involved in the applications of materials in medicine. This new edition incorporates key updates to reflect the latest relevant research in the field, particularly in the applications section, which includes the latest in topics such as nanotechnology, robotic implantation, and biomaterials utilized in cancer research detection and therapy. Other additions include regenerative engineering, 3D printing, personalized medicine and organs on a chip. Translation from the lab to commercial products is emphasized with new content dedicated to medical device development, global issues related to translation, and issues of quality assurance and reimbursement. In response to customer feedback, the new edition also features consolidation of redundant material to ensure clarity and focus. Biomaterials Science, 4th edition is an important update to the best-selling text, vital to the biomaterials’ community. The most comprehensive coverage of principles and applications of all classes of biomaterials Edited and contributed by the best-known figures in the biomaterials field today; fully endorsed and supported by the Society for Biomaterials Fully revised and updated to address issues of translation, nanotechnology, additive manufacturing, organs on chip, precision medicine and much more. Online chapter exercises available for most chapters

Biomaterials for Passive and Active Immunomodulation

Biomaterials for Passive and Active Immunomodulation Book
Author : Jessica Leigh Schlosser
Publisher : Unknown
Release : 2014
ISBN : 9781321022452
Language : En, Es, Fr & De

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Book Description :

To mitigate a chronic inflammatory host response, engineers often choose an inert biomaterial that limits unwanted effects on the immune system. Poly(ethylene glycol)(PEG) is one such material used to passively modulate immune activation. PEG's unique ability to tightly associate with multiple water molecules per monomer, attributed to the hydrophilicity and charge distribution across the polymerized macromer, renders the material "invisible" to the body. Additionally, PEG is non-toxic, water soluble, and easily modified, making this polymer one of the most useful biomaterials in the field today. Unfortunately, PEG still ilicits an undesired inflammatory response from macrophages, characterized by release of cytokines TNF-[alpha] and IL-1[beta]. In previous studies, embedding or administering a protein that actively decreases this cytokine release profile can increase the biocompatibility of a biomaterial. CD200, a membrane glycoprotein whose receptor is found exclusively on myeloid cells, is one such anti-inflammatory protein. This self-recognition molecule sends an inhibitory signal when bound to CD200R on macrophages, thus reducing TNF-[alpha] and IL-[beta] expression. We proposed to combine passive (PEG) and active (CD200) immunomodulatory mechanisms for further control of biomaterial compatibility. Through confocal microscopy we show evidence of CD200 immobilization onto a PEG hydrogel, and ultimately demonstrate that these CD200-functionalized PEG hydrogels not only decrease the concentration of inflammatory cytokines in BMDMs, but also limit the inflammatory response in vivo up to 24 hours.

Designing a Novel Immunomodulatory Surface Modification to Promote Biomaterial tissue Integration

Designing a Novel Immunomodulatory Surface Modification to Promote Biomaterial tissue Integration Book
Author : Emily Beth Lurier
Publisher : Unknown
Release : 2019
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The foreign body response (FBR) to implanted biomaterials provides a major challenge for successful biomaterial-tissue integration in the body. During the FBR, biomaterials are encapsulated in a collagenous, scar-like capsule that prevents the material from interacting with the surrounding tissue. Ultimately, the biomaterial will fail due to degradation and encapsulation, resulting in the removal and replacement of the implant. The primary culprit of the FBR is macrophages, the primary cell type of the inflammatory response. Macrophages exist on a spectrum of behaviors, typically transitioning from an "M1" pro-inflammatory to "M2" pro-healing phenotype in healthy wound healing. The M2 phenotype can be further broken down into interleukin-4 (IL4) stimulated "M2a" and IL10 stimulated "M2c" macrophages, although the differences between these phenotypes in biomaterial-tissue integration have not been fully elucidated. During the FBR, this phenotypic transition is halted, and macrophages exhibit chronic M1 behavior leading to fibrous capsule formation. While many biomaterial strategies to inhibit chronic M1 behavior and promote the natural M1-to-M2 phenotype switch have been investigated, there is currently no method to inhibit the FBR. Furthermore, methods to temporally control macrophage behavior to prevent chronic responses in either direction have not been successfully implemented. Therefore, the overarching goals of this work were to (1) design an affinity-based cytokine release system to modulate macrophage phenotype over time and (2) test the ability of the drug delivery system using biotin-avidin to temporally modulate macrophage phenotype both in vitro and in vivo. First, an investigation into the M2c phenotype revealed that this phenotype may act at early stages of wound healing, primarily contributing to matrix remodeling. M2c macrophages were found to secrete high quantities of matrix degrading enzymes suggesting that this phenotype may not be beneficial in biomaterial-tissue integration. Comparatively, M2a macrophages have been previously shown to inhibit fibrous capsule formation and promote angiogenesis in the context of biomaterial-tissue integration. Therefore, the M2a polarizing cytokine IL4 was bound to Gelfoam scaffolds, used as a model biomaterial throughout, via the biotin-avidin affinity conjugation system. The biotin avidin system has been previously shown to release proteins over time and has the potential for creating a loadable protein drug delivery system in vitro. However, the ability to modulate macrophage activation by controlling the parameters of the system over time have not been thoroughly investigated. The effects of modulating both the fold molar excess of biotin on the scaffold surface and altering the avidin variants were investigated. Increasing the fold molar excess (FME) of biotin on the scaffold conjugated with CaptAvidin, and not Streptavidin, was shown to decrease IL4 release over time. Additionally, in a similar manner, increasing the FME of biotin on the scaffold with CaptAvidin and IL4 decreased M2a activation in vitro. Scaffolds with low levels of biotinylation in vivo were shown to have the highest reduction in fibrous capsule formation compared to groups with no IL4, adsorbed IL4 or a high degree of biotinylation. However, differences in gene expression signatures of explants were minimal. A more thorough investigation is required to determine the in vivo effects of modified scaffolds on fibrosis and angiogenesis. Overall, modifying scaffolds with biotin-avidin shows great potential in designing immunomodulatory drug delivery systems. to control macrophage activation over time. Future studies should focus on utilizing the biotin-avidin system as a loadable cytokine release system to control the M1-to-M2 phenotypic transition which would have significant impact on treating pathologies where this transition is halted, like fibrosis and chronic wounds.

Novel Biomaterials for Regenerative Medicine

Novel Biomaterials for Regenerative Medicine Book
Author : Heung Jae Chun,Kwideok Park,Chun-Ho Kim,Gilson Khang
Publisher : Springer
Release : 2018-10-24
ISBN : 9811309477
Language : En, Es, Fr & De

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Book Description :

This book explores in depth a wide range of new biomaterials that hold great promise for applications in regenerative medicine. The opening two sections are devoted to biomaterials designed to direct stem cell fate and regulate signaling pathways. Diverse novel functional biomaterials, including injectable nanocomposite hydrogels, electrosprayed nanoparticles, and waterborne polyurethane-based materials, are then discussed. The fourth section focuses on inorganic biomaterials, such as nanobioceramics, hydroxyapatite, and titanium dioxide. Finally, up-to-date information is provided on a wide range of smart natural biomaterials, ranging from silk fibroin-based scaffolds and collagen type I to chitosan, mussel-inspired biomaterials, and natural polymeric scaffolds. This is one of two books to be based on contributions from leading experts that were delivered at the 2018 Asia University Symposium on Biomedical Engineering in Seoul, Korea – the companion book examines in depth the latest enabling technologies for regenerative medicine.

Engineering Materials for Stem Cell Regeneration

Engineering Materials for Stem Cell Regeneration Book
Author : Faheem A. Sheikh
Publisher : Springer Nature
Release : 2021-11-29
ISBN : 9811644209
Language : En, Es, Fr & De

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Book Description :

Download Engineering Materials for Stem Cell Regeneration book written by Faheem A. Sheikh, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Biomaterials for Organ and Tissue Regeneration

Biomaterials for Organ and Tissue Regeneration Book
Author : Nihal Vrana,Helena Knopf-Marques,Julien Barthes
Publisher : Woodhead Publishing
Release : 2020-03-20
ISBN : 0081029071
Language : En, Es, Fr & De

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Book Description :

Biomaterials for Organ and Tissue Regeneration: New Technologies and Future Prospects examines the use of biomaterials in applications related to artificial tissues and organs. With a strong focus on fundamental and traditional tissue engineering strategies, the book also examines how emerging and enabling technologies are being developed and applied. Sections provide essential information on biomaterial, cell properties and cell types used in organ generation. A section on state-of-the-art in organ regeneration for clinical purposes is followed by a discussion on enabling technologies, such as bioprinting, on chip organ systems and in silico simulations. Provides a systematic overview of the field, from fundamentals, to current challenges and opportunities Encompasses the classic paradigm of tissue engineering for creation of new functional tissue Discusses enabling technologies such as bioprinting, organ-on-chip systems and in silico simulations

Synthesis Functionalization and Clinical Translation of Pharmaceutical Biomaterials

Synthesis  Functionalization  and Clinical Translation of Pharmaceutical Biomaterials Book
Author : Jianxun Ding,Mingqiang Li,Shixian Lv
Publisher : Frontiers Media SA
Release : 2021-08-18
ISBN : 2889711935
Language : En, Es, Fr & De

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Book Description :

Download Synthesis Functionalization and Clinical Translation of Pharmaceutical Biomaterials book written by Jianxun Ding,Mingqiang Li,Shixian Lv, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Biomaterials

Biomaterials Book
Author : Petrică Vizureanu,Claudia Manuela Da Cunha Ferreira Botelho
Publisher : BoD – Books on Demand
Release : 2020-11-11
ISBN : 1789844649
Language : En, Es, Fr & De

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Book Description :

This book provides an overview of biomaterials science with a focus on health and medical applications that can be improved with new biomaterials with non-allergenic elements. These materials are designed to meet functional requirements and overcome the disadvantages of classical alloys used as biomaterials in human tissue. Over seven chapters, this volume explains the problems created by classical alloys and examines how the new generation of biomaterials helps both doctors and patients. It is designed for students, doctors, patients, and researchers worldwide.

Advanced Therapies for Cardiac Regeneration

Advanced Therapies for Cardiac Regeneration Book
Author : Valeria Chiono,Ipsita Roy,Monica Boffito,Irene Carmagnola,Susanna Sartori
Publisher : Frontiers Media SA
Release : 2021-04-13
ISBN : 2889666956
Language : En, Es, Fr & De

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Book Description :

The Research Topic is organized in the framework of the project BIORECAR (grant number: 772168; http://www.biorecar.polito.it/index.html)

Biomaterials for Tissue Engineering for Rheumatoid Arthritis Based on Controlling Dendritic Cell Phenotype

Biomaterials for Tissue Engineering for Rheumatoid Arthritis Based on Controlling Dendritic Cell Phenotype Book
Author : Jaehyung Park
Publisher : Unknown
Release : 2009
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The host response toward biomaterial component of tissue-engineered devices has been extensively investigated. The objective of this research was to understand the response of dendritic cells (DCs) to different biomaterials upon contact and identify biomaterials suitable for use in tissue engineering constructs for rheumatoid arthritis (RA) applications. Differential levels of functional DC maturation were observed depending on the type of biomaterial in 2-dimensional films or 3-dimensional scaffolds used to treat immature DCs; Poly(lactic-co-glycolic acid) (PLGA) or chitosan supported higher levels of DC maturation, as compared to immature DCs. Alginate supported moderate levels of DC maturation. Agarose did not support DC maturation whereas hyaluronic acid inhibited DC maturation. Further, these DCs treated with different biomaterials induced differential phenotype and polarization of autologous T cells upon co-culture of DCs and T cells; DCs treated with PLGA induced T helper type I with immunogenic response while DCs treated with agarose did T helper type II with tolerogenic response. Effect of different biomaterials (PLGA and agarose) was assessed in vivo upon implantation of them into the knee joint of RA-induced rabbit. Total leukocyte concentrations in the peripheral blood or in the joint lavage of the left knees (untreated control) were observed in differential levels depending on the biomaterial implant, possibly due to the systemic circulation of the peripheral blood. Furthermore, cartilage and bone healing progression was differentially observed in the osteochondral defect of the knee joint of RA-induced rabbit, depending on type of biomaterial scaffold implanted into the defect. Collectively, these results demonstrate the multifunctional impacts of inherently different biomaterials on in vitro immunomodulation of phenotype and polarization of DCs and autologous T cells. Furthermore, taken together with these immunomodulatory impacts of biomaterials, in vivo effects of different biomaterial scaffolds on RA environment shown in this study can suggest the criteria of selection and design of biomaterials for orthopedic tissue engineering, which may ultimately be best integrated into the diseased cartilage and bone.