Immunology In The Twentieth Century

Book Description :

A History of Modern Immunology: A Path Toward Understanding describes, analyzes, and conceptualizes several seminal events and discoveries in immunology in the last third of the 20th century, the era when most questions about the biology of the immune system were raised and also found their answers. Written by an eyewitness to this history, the book gives insight into personal aspects of the important figures in the discipline, and its data driven emphasis on understanding will benefit both young and experienced scientists. This book provides a concise introduction to topics including immunological specificity, antibody diversity, monoclonal antibodies, major histocompatibility complex, antigen presentation, T cell biology, immunological tolerance, and autoimmune disease. This broad background of the discipline of immunology is a valuable companion for students of immunology, research and clinical immunologists, and research managers in the pharmaceutical and biotechnology industries. Contains the history of major breakthroughs in immunology featured with authenticity and insider details Gives an insight into personal aspects of the players in the history of immunology Enables the reader to recognize and select data of heuristic value which elucidate important facets of the immune system Provides good examples and guidelines for the recognition and selection of what is important for the exploration of the immune system Gives clear separation of descriptive and interpretive parts, allowing the reader to distinguish between facts and analysis provided by the author

Book Description :

Immunology in the Twentieth Century: From Basic Science to Clinical Application grew out of common knowledge that those who survived many of the common infectious diseases rarely contracted the same disease again. This book charts the historical development of this vital branch of medicine in a concise volume, covering both the basic science involved and the clinical applications. Immunology as a distinctive subject developed in the mid-twentieth century as researchers started to understand how the adaptive immune system aids the defense against pathogens. The subject has grown in importance and diversified into specialist fields, such as immunohistochemistry, immunogenetics and immunopathology.

Book Description :

Immunology in the Twentieth Century: From Basic Science to Clinical Application grew out of common knowledge that those who survived many of the common infectious diseases rarely contracted the same disease again. This book charts the historical development of this vital branch of medicine in a concise volume, covering both the basic science involved and the clinical applications. Immunology as a distinctive subject developed in the mid-twentieth century as researchers started to understand how the adaptive immune system aids the defense against pathogens. The subject has grown in importance and diversified into specialist fields, such as immunohistochemistry, immunogenetics and immunopathology. Provides a concise overhead of the history of immunology and its applications in medicine Includes a discussion of the scientists who were pioneers in landmark discoveries in immunology Summarizes the clinical applications of major discoveries

Book Description :

A Historical Perspective on Evidence-Based Immunology focuses on the results of hypothesis-driven, controlled scientific experiments that have led to the current understanding of immunological principles. The text helps beginning students in biomedical disciplines understand the basis of immunologic knowledge, while also helping more advanced students gain further insights. The book serves as a crucial reference for researchers studying the evolution of ideas and scientific methods, including fundamental insights on immunologic tolerance, interactions of lymphocytes with antigen TCR and BCR, the generation of diversity and mechanism of tolerance of T cells and B cells, the first cytokines, the concept of autoimmunity, the identification of NK cells as a unique cell type, the structure of antibody molecules and identification of Fab and Fc regions, and dendritic cells. Provides a complete review of the hypothesis-driven, controlled scientific experiments that have led to our current understanding of immunological principles Explains the types of experiments that were performed and how the interpretation of the experiments altered the understanding of immunology Presents concepts such as the division of lymphocytes into functionally different populations in their historical context Includes fundamental insights on immunologic tolerance, interactions of lymphocytes with antigen TCR and BCR, and the generation of diversity and mechanism of tolerance of T and B cells

Book Description :

Those entering the field of transplantation are frequently unaware of the topics historical roots and even of the background on which modern discoveries in tolerance, histocompabatibility antigens, and xenotransplantation are based. A History of Transplantation Immunology is an account, written by one of the founding fathers of the field, of how tissue and organ transplantation has become one of the most successful branches of late 20th century medicine. The book helps place the work of contemporary scientists into its proper context and makes fascinating reading for immunologists in all stages of their career. Describes landmarks in immunology and places them in historical context Beautifully written by one of the founding fathers of the field Portrays the surprising history of events in a colorful and readable manner Contains biographical sketches of some of the pioneers Illustrates the development of key ideas in immunology--tolerance, graft rejection, and transplantation Foreword by Ray Owen

Book Description :

Milestones in Immunology: Based on Collected Papers contains scientific milestones relating to the history of medicine over the past two centuries. The book highlights the contributions of pioneering scientists whose discoveries have paved the way for researchers working in the field of immunology. As the science of immunology grew from knowledge that survivors of common infectious diseases rarely contracted them again, the book uses this as a central thesis, helping readers understand how the adaptive immune system aids in defense against pathogens. In addition, the book covers special fields, such as immunohistochemistry, immunogenetics and immunopathology. For the past century, immunology has fascinated and inspired some of the greatest scientists of our time. Numerous Nobel Prizes have been awarded for fundamental discoveries in immunology, from Paul Ehrlich’ work on antibodies (1908) to the studies of Zinkernagel and Doherty (1986) elucidating mechanisms of cell-mediated immunity. Provides on update on developments since the publication of Nobel prize winning research for fundamental discoveries in immunology Discusses the changing theories and technologies that guided the field Lists all the important discoveries and books in the field Explains, in detail, the many Nobel prize-winning contributions of immunologists Provides recognition of the scientists who were pioneers of landmark discoveries in immunology

Book Description :

A History of Medical Bacteriology and Immunology provides the account of the history of bacteriology from the year 1900 to 1938. This book presents details about the discovery of the important pathogenic bacteria of man, of how they were shown to be causally related to disease, and of the use of these discoveries in the diagnosis, treatment, and prevention of disease. Other topics discussed include the development of the germ theory of infectious diseases; contribution of Louis Pasteur and Robert Koch to medical bacteriology; and discovery of the more important human pathogenic bacteria. This text also discusses the scientific basis and practical application of immunology to medicine; main developments in bacteriology during the early 20th century; and chemotherapy of bacterial disease. This medically oriented text is beneficial for students and individuals conducting study on medical bacteriology and immunology.

Book Description :

With over forty chapters, written by leading scholars, this comprehensive volume represents the best work in America, Europe, and Asia. Geographical diversity of the authors is reflected in the different perspectives devoted to the subject, and all major disciplinary developments are covered. There are also sections concerning the countries that have made the most significant contributions, the relationship between science and industry, the importance of instrumentation, and the cultural influence of scientific modes of thought. Students and professionals will come to appreciate how, and why, science has developed - as with any other human activity, it is subject to the dynamics of society and politics.

Book Description :

This work on science in the 20th century represents work in America, Europe and Asia. It includes such topics as the countries that have made the most significant contributions, the relationship between science and industry and the importance of instrumentation.

Book Description :

With over forty chapters, written by leading scholars, this comprehensive volume represents the best work in America, Europe and Asia. Geographical diversity of the authors is reflected in the different perspectives devoted to the subject, and all major disciplinary developments are covered. There are also sections concerning the countries that have made the most significant contributions, the relationship between science and industry, the importance of instrumentation, and the cultural influence of scientific modes of thought. Students and professionals will come to appreciate how, and why, science has developed - as with any other human activity, it is subject to the dynamics of society and politics.

Book Description :

This work is both a history of the renowned Liverpool School of Tropical Medicine and a study of the development of the discipline of tropical medicine in Britain in the twentieth century. The story of the School, and of the personalities and principles that have given it direction since its foundation, is presented against the background of the sweeping medical and social changes of this century. The result is a unique and dynamic study which demonstrates that as a socially-, politically- and economically- determined medical specialty, the history of tropical medicine is an ideal medium through which to explore the forces which shape medicine and its application in the contexts of imperialism, independence and the contemporary third world.

Book Description :

General Immunology provides a general overview of the immune system. It presents topics in immunology from all living groups, treating cells, tissues, organs, and organismal levels of biological organization. The book contains 23 chapters organized into eight sections. Section I serves as an introduction to immunology—a science, a sketch of its history, some of its more recent contributors, something about gathering facts, immunology journals, and the entire biomedical enterprise of which immunology is just a part. Section II is devoted to antigens while Section III examines the immune system in chordates and the ontogeny of the immune system. Section IV on cells of the immune system covers monocytes, macrophages, the three granulocytic types, and mast cells. Section V deals with phagocytosis and the interaction of lymphocytes. Section VI is devoted to antigens in relation to antibody synthesis, antigen-antibody interactions, immunologlobulin structure, and immunologlobulin assembly. Section VII on organs of the immune system examines bone marrow, thymus, spleen, lymph nodes, and lymphoid aggregations. Section VIII discusses the evolution of the immune system. This text was written for advanced undergraduates. However, its comprehensiveness makes it useful to immunologists and biologists at all levels as well as medical students and clinicians.

Book Description :

Immunity is as old as illness itself, yet historians have only just begun to take up the challenge of reconstructing the modern transformation of attempts to protect against disease. Crafting Immunity assembles in one volume the most recent efforts of an international group of scholars to place the diverse practices of immunity in their historical contexts. It is this diversity that provides the book with its greatest source of strength. Collectively, the papers in this volume suggest that it was the craft-like, small-scale, and local conditions of clinical medicine that turned the immunity of individuals and populations into biomedical objects. That is to say, the modern conception of immunity was at least as much the product of the work of healing as it was the systematic result of discoveries about the immune system. Working outside the narrow confines of laboratory histories, Crafting Immunity is the first attempt to set the problems of immunity into a variety of social, technological, institutional and intellectual contexts. It will appeal not only to historians and sociologists of health, but also to social and cultural historians interested in the biomedical creation of modern health regimens.

Book Description :

Lectures, Parties, and Nobel Prizes: living and researching at the Basel Institute for Immunology By the early seventies of the 20th century, the Basel Institute for Immunology had become one of the largest - and certainly the most prominent - immunology institutes in the world. Its lean structure was highly successful, and the quality of the research and its reputation remained outstandingly high throughout the three decades it existed. This book describes the institute's history from its conception and the laying of the foundation stone in 1969 by the pharmaceutical company Roche to the triumph of three Nobel Prizes (1984 and 1987) for Niels K. Jerne, Georges K�hler and Susumu Tonegawa. Can all this be portrayed to make the layman understand it and the scientist relish it? Indeed, the book succeeds in tuning in to what fascinates students, advanced researchers and scientists, historians, policy makers and philanthropists alike. The narrative reveals many aspects of the institute's life and also describes all its research and achievements. Immunologists at every level, from beginners to old hands, will find something of interest to them in this history, and some readers will even make use of the huge database (documents, pictures and films) linked to the book by hundreds of QR codes.

Book Description :

Every aspect of immune function and host defense is dependent upon a proper supply and balance of nutrients. Severe malnutrition can cause significant alteration in immune response, but even subclinical deficits may be associated with an impaired immune response, and an increased risk of infection. Infectious diseases have accounted for more off-duty days during major wars than combat wounds or nonbattle injuries. Combined stressors may reduce the normal ability of soldiers to resist pathogens, increase their susceptibility to biological warfare agents, and reduce the effectiveness of vaccines intended to protect them. There is also a concern with the inappropriate use of dietary supplements. This book, one of a series, examines the impact of various types of stressors and the role of specific dietary nutrients in maintaining immune function of military personnel in the field. It reviews the impact of compromised nutrition status on immune function; the interaction of health, exercise, and stress (both physical and psychological) in immune function; and the role of nutritional supplements and newer biotechnology methods reported to enhance immune function. The first part of the book contains the committee's workshop summary and evaluation of ongoing research by Army scientists on immune status in special forces troops, responses to the Army's questions, conclusions, and recommendations. The rest of the book contains papers contributed by workshop speakers, grouped under such broad topics as an introduction to what is known about immune function, the assessment of immune function, the effect of nutrition, and the relation between the many and varied stresses encountered by military personnel and their effect on health.

Book Description :

In this detailed history of infectious diseases, John Hamilton draws upon his extensive experience with other faculty members and staff and delivers an insider’s account of some of the more prevalent and/or serious diseases, the physicians and researchers studying them, and the programs supporting them at Duke University and its affiliate, the Durham VA Medical Center. Combining insights from his own experience and almost 100 interviews of current and former faculty members and staff and his complete access to the Medical Center Archives, he explores: Medical education, public health, and the disease portfolio before and during the 20th century in the world, the state and the city of Durham, North Carolina; Reasons why James B. “Buck” Duke invested his money into what became Duke University; Relevant personal and professional papers belonging to departed or deceased faculty; And provides extensive references for those who wish to delve into the science.

Book Description :

In this innovative, short, new textbook, Rod Langman offers a conceptual framework within which students can understand the evolution of the immune system. Evolutionary selection for resistance to infectious disease is shown to be the driving force that has shaped the immune system into a remarkably effective and efficient system of defense. In the midst of the current information explosion in immunological science, when many students are under the impression that the immune system is almost too complex to understand as a whole, The Immune System can be used alone as a text for an introductory course or used in conjunction with any of the several descriptive texts already on the market.

Book Description :

"A History of Modern Immunology: A Path Toward Understanding" describes, analyzes, and conceptualizes several seminal events and discoveries in immunology in the last third of the 20th century, the era when most questions about the biology of the immune system were raised and also found their answers. Written by an eyewitness to this history, the book gives insight into personal aspects of the important figures in the discipline, and its data driven emphasis on understanding will benefit both young and experienced scientists. This book provides a concise introduction to topics including immunological specificity, antibody diversity, monoclonal antibodies, major histocompatibility complex, antigen presentation, T cell biology, immunological tolerance, and autoimmune disease. This broad background of the discipline of immunology is a valuable companion for students of immunology, research and clinical immunologists, and research managers in the pharmaceutical and biotechnology industries. Contains the history of major breakthroughs in immunology featured with authenticity and insider detailsGives an insight into personal aspects of the players in the history of immunologyEnables the reader to recognize and select data of heuristic value which elucidate important facets of the immune systemProvides good examples and guidelines for the recognition and selection of what is important for the exploration of the immune systemGives clear separation of descriptive and interpretive parts, allowing the reader to distinguish between facts and analysis provided by the author

Book Description :

Public health action often involved controversies and recriminations over past failures.

Book Description :

Selected as a Doody's Core Title for 2022! Defining the field of immunology for 40 years, Paul’s Fundamental Immunology continues to provide detailed, authoritative, up-to-date information that uniquely bridges the gap between basic immunology and the disease process. The fully revised 8th edition maintains the excellence established by Dr. William E. Paul, who passed away in 2015, and is now under new editorial leadership of Drs. Martin F. Flajnik, Nevil J. Singh, and Steven M. Holland. It’s an ideal reference and gold standard text for graduate students, post-doctoral fellows, basic and clinical immunologists, microbiologists and infectious disease physicians, and any physician treating diseases in which immunologic mechanisms play a role.