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Immune Biology Of Allogeneic Hematopoietic Stem Cell Transplantation

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Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation

Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation Book
Author : Gerard Socie,Robert Zeiser,Bruce R. Blazar
Publisher : Academic Press
Release : 2018-11-22
ISBN : 0128134399
Language : En, Es, Fr & De

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Book Description :

Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation: Models in Discovery and Translation, Second Edition once again provides clinical and scientific researchers with a deep understanding of the current research in this field and the implications for translational practice. By providing an overview of the immune biology of HSCT, an explanation of immune rejection, and detail on antigens and their role in HSCT success, this book embraces biologists and clinicians who need a broad view of the deeply complex processes involved. It then moves on to discuss the immunobiology mechanisms that influence graft-versus-host disease (GVHD), graft-versus-leukemia effect, and transplantation success. Using illustrative figures, highlighting key issues, describing recent successes, and discussing unanswered questions, this book sums up the current state of HSCT to enhance the prospects for the future. The second edition is fully revised and includes new chapters on microbiome, metabolism, kinase targets, micro-RNA and mRNA regulatory mechanisms, signaling pathways in GVHD, innate lymphoid system development, recovery and function in GVHD, genetically engineered T-cell therapies, immune system engagers for GVHD and graft-versus-tumor, and hematopoietic cell transplant for tolerance induction in solid organ grafts. Brings together perspectives from leading laboratories and clinical research groups to highlight advances from bench to the bedside Guides readers through the caveats that must be considered when drawing conclusions from studies with animal models before correlating to clinical allogeneic hematopoietic stem cell transplantation (HSCT) scenarios Categorizes the published advances in various aspects of immune biology of allogeneic HSCT to illustrate opportunities for clinical applications

Hematopoietic Stem Cell Transplantation

Hematopoietic Stem Cell Transplantation Book
Author : Robert J. Soiffer
Publisher : Springer Science & Business Media
Release : 2008-11-14
ISBN : 9781597454384
Language : En, Es, Fr & De

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Book Description :

Remarkable developments in the field of transplantation have created opportunities to address the formidable challenges of transplantation across histocompatibility barriers, stem cell expansion, and prevention of complications and generation of graft-vs-tumor activity to eradicate residual disease. Stem Cell Transplantation for Hematologic and Other Disorders, Second Edition provides a glimpse into potential future applications of bone marrow derived stem cells in the field of cardiac repair. The updated chapters introduce the biologic underpinnings of hematopoietic cell transplantation, basic stem cell biology, immunobiology, and histocompatibility, with emphasis on indications and results of transplantation for specific diseases. Written by experts in the field, Stem Cell Transplantation for Hematologic Disorders, Second Edition provides seasoned professionals with a complete understanding of the current state of transplantation biology as well as a clear vision into the future.

The Biology of Human Invariant Natural Killer T Cells and Regulatory T Cells in Allogeneic Hematopoietic Stem Cell Transplantation

The Biology of Human Invariant Natural Killer T Cells and Regulatory T Cells in Allogeneic Hematopoietic Stem Cell Transplantation Book
Author : Bryan Jiaming Xie
Publisher : Unknown
Release : 2021
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Allogeneic hematopoietic stem cell transplant (HSCT) can be used as a curative treatment for patients with hematologic malignancies; however, acute graft-versus-host disease (aGVHD) is a highly inflammatory disease and a major complication that can occur following this therapy. Two populations capable of regulating immune responses are invariant natural killer T (iNKT) and regulatory T (Treg) cells, but their biology in the clinical aGVHD setting is not fully understood. Thus, I examined how iNKT and Treg cells regulate aGVHD in the clinical setting. To study human iNKT cells, I used a high-dimensional, data-driven approach to devise a framework for parsing human iNKT cell heterogeneity. A population of iNKT cells characterized by HLA-DR expression was found to be enriched in aGVHD patients and associated with exhaustion markers and a Th1 profile, suggesting a loss of immunoregulatory mechanisms in aGVHD. This phenotype, along with other discovered phenotypic markers, were also associated with aGVHD outcomes, suggesting that iNKT cells can potentially serve as a biomarker and therapeutic target in allogeneic HSCT. Beyond these potential clinical implications, a new framework was discovered for understanding human iNKT cell heterogeneity that advances our knowledge of human iNKT cell biology. As our understanding of fundamental human Treg cell biology is more advanced, a phase I/II study of the infusion of Treg cells with hematopoietic stem cells to prevent aGVHD in adult patients undergoing myeloablative allogeneic HSCT for hematological malignancies has been started and is ongoing. Clinically, greater than grade II aGVHD was noted in two patients in the first cohort of five patients who received cryopreserved Treg cells. In a second cohort of seven patients who received fresh Treg cells and single agent aGVHD prophylaxis, none developed aGVHD. A key finding is that patients in the second cohort showed immune reconstitution comparable to patients who underwent allogeneic HSCT on standard-of-care. Together, these studies reveal new insights into the biology of human iNKT and Treg cells in the clinical aGVHD setting.

Cells of the Immune System

Cells of the Immune System Book
Author : Ota Fuchs,Seyyed Shamsadin Athari
Publisher : BoD – Books on Demand
Release : 2020-05-13
ISBN : 1789855837
Language : En, Es, Fr & De

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Book Description :

The cells of the immune system are lymphocytes (T-cells, B-cells and NK (natural killer) cells), neutrophils, eosinophils, and monocytes/macrophages. This book is an overview of some types of these cells and their role in recognizing and/or reacting against foreign material. The immune system is characterized by collaboration between cells and proteins. The development of all cells of the immune system begins in the bone marrow with a hematopoietic stem cell. Two chapters deal with neutrophils, three chapters with T-cells, four chapters with eosinophils, and other chapters review the immunomodulation of macrophages, the role of transcription factor KLF4 in regulating plasticity of myeloid-derived suppressor cells, immune reconstitution after allogeneic hematopoietic stem cell transplantation, and role of sorption detoxification in the therapy of acute radiation sickness.

Hematopoietic Stem Cell Transplantation

Hematopoietic Stem Cell Transplantation Book
Author : Michael R. Bishop
Publisher : Springer Science & Business Media
Release : 2009-09-25
ISBN : 9780387785806
Language : En, Es, Fr & De

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Book Description :

The dogmas of the quiet past are inadequate to the stormy present. The occasion is piled high with difficulty, and we must rise with the occasion. As our case is new, so we must think anew and act anew. Abraham Lincoln, 1862 When I came across this quote, it made me recall my first participation at an international meeting on bone marrow transplantation, at a time when this was the only term that was used to describe the field. During a particular session there was a presentation on the use of peripheral blood as the sole source of stem cells for transplantation, and a member of the audience rose to state that it was medically unethical to consider such treatment, as it certainly could not contain stem cells. Now nearly twenty years later, peripheral blood is the predominant source of stem cells used for hematopoietic stem cell transplantation. In the same period of time there have been several other dogmatic opinions, which permeate all of medicine, that have come and gone in the field of hematopoietic stem cell transplantation, and will continue to do so with advancements from basic and clinical research. It is within this context that the format of this book was devised. Traditionally reviews on specific topics related to hematopoietic stem cell transplantation reflect the views of a single author or a research group.

Graft Versus Host Disease New Insights for the Healthcare Professional 2013 Edition

Graft Versus Host Disease  New Insights for the Healthcare Professional  2013 Edition Book
Author : Anonim
Publisher : ScholarlyEditions
Release : 2013-07-22
ISBN : 1481659014
Language : En, Es, Fr & De

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Book Description :

Graft-Versus-Host Disease: New Insights for the Healthcare Professional: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Diagnosis and Screening. The editors have built Graft-Versus-Host Disease: New Insights for the Healthcare Professional: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Diagnosis and Screening in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Graft-Versus-Host Disease: New Insights for the Healthcare Professional: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Pediatric Hematopoietic Stem Cell Transplantation for Pharmacists

Pediatric Hematopoietic Stem Cell Transplantation for Pharmacists Book
Author : Carolina Witchmichen Penteado Schmidt
Publisher : Springer Nature
Release : 2020-06-02
ISBN : 3030434915
Language : En, Es, Fr & De

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Book Description :

This unique book is the first on pediatric hematopoietic stem cell transplantation that is especially intended for pharmacists – in recognition of the fact that Pediatric Oncology Pharmacy is an area where more and more specific knowledge is required in daily practice, yet pharmacists who work in pediatric stem cell transplantation do not have a book addressing their specific needs. This pioneering book will likely become the new gold standard for practice, addressing subjects such as stem cells and their differentiation mechanisms; aspects of embryonic and non-embryonic stem cells; stem cell transplantation in pediatrics; stem cell sources and related technical choices; stem cell donors; scheduling transplantations; diseases and chemotherapy protocols that require stem cell transplantation; stem cell homing; engraftment and repopulation of stem cells in bone marrow; autologous stem cell transplantation in pediatrics; allogeneic stem cell transplantation in pediatrics; and indications for autologous and allogeneic pediatric stem cell transplantation. Further, it discusses pediatric graft-versus-host disease and the pharmacist; antibacterial and antifungal prophylaxis; detailed chemotherapy, conditioning and trials for pediatric stem cell transplantation; conditioning granulocyte colony-stimulating factor (G-CSF) in pediatric stem cell transplantation; analyzing prescriptions and programming a pediatric stem cell transplantation; handling chemotherapy and adjuvant drugs for pediatric stem cell transplantation; stem cell transplantation in children up to 1 year old; and clinical pharmacy in pediatric stem cell transplantation. An easy-to-read yet comprehensive guide covering a wide range of topics essential to daily practice, the book offers an invaluable asset for pediatric hemato/ oncology pharmacists, hematologist pharmacists, clinical pharmacists, pediatric pharmacists, pharmaceutical residents and researchers alike.

Thomas Hematopoietic Cell Transplantation

Thomas  Hematopoietic Cell Transplantation Book
Author : Stephen J. Forman,Robert S. Negrin,Joseph H. Antin,Frederick R. Appelbaum
Publisher : John Wiley & Sons
Release : 2015-12-23
ISBN : 1118416074
Language : En, Es, Fr & De

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Book Description :

Fully revised for the fifth edition, this outstanding reference on bone marrow transplantation is an essential, field-leading resource. Extensive coverage of the field, from the scientific basis for stem-cell transplantation to the future direction of research Combines the knowledge and expertise of over 170 international specialists across 106 chapters Includes new chapters addressing basic science experiments in stem-cell biology, immunology, and tolerance Contains expanded content on the benefits and challenges of transplantation, and analysis of the impact of new therapies to help clinical decision-making Includes a fully searchable Wiley Digital Edition with downloadable figures, linked references, and more References for this new edition are online only, accessible via the Wiley Digital Edition code printed inside the front cover or at www.wiley.com/go/forman/hematopoietic.

How to improve immune reconstitution in allogeneic hematopoietic stem cell transplantation

How to improve immune reconstitution in allogeneic hematopoietic stem cell transplantation  Book
Author : Antoine Toubert,Hermann Einsele
Publisher : Frontiers Media SA
Release : 2015-03-12
ISBN : 2889194914
Language : En, Es, Fr & De

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Book Description :

Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is widely used in the treatment of haematological malignancies as a form of immunotherapy acting through a graft-versus-leukemia (GvL) reaction. This curative allogeneic response can be associated with severe drawbacks, such as frequent and severe graft-versus-host disease (GvHD) and a long-lasting immunodeficiency, especially now with the development of innovative strategies such as umbilical cord blood transplantation or transplants from haplo-identical family donors (Haplo-HSCT). In the long-term follow-up of these patients, severe post-transplant infections, relapse or secondary malignancies may be directly related to persistent immune defects. Reconstitution of the different lymphocyte populations (B, T, NK, NKT) and antigen presenting cells of myeloid origin (monocytes, macrophages and dendritic cells) should be considered not only quantitatively but especially qualitatively, in terms of functional subsets. Immune deficiency leading to an increased susceptibility to infections lasts for more than a year. Although infections that occur in the first month mostly result from a deficiency in both granulocytes and mononuclear cells (MNC), later post-engraftment infections are due to a deficiency in MNC subsets, primarily CD4 T-cells and B-cells. T-cell reconstitution has been extensively studied because of the central role of T-cells in mediating both GvHD, evidenced by the reduced incidence of this complication following T-Cell depletion, and a GvL effect as shown by DLI. In the recent years there has been renewed interest in the role of NK-cells, especially in the context of Haplo-HSCT, and in B-cell reconstitution. This Frontiers Research Topic will provide state of the art knowledge of the mechanisms of immune reconstitution in an allogeneic environment, in order to improve monitoring and therapeutic intervention in allo-HSCT patients.

Thomas Hematopoietic Cell Transplantation

Thomas  Hematopoietic Cell Transplantation Book
Author : Stephen J. Forman,Robert S. Negrin,Joseph H. Antin,Frederick R. Appelbaum
Publisher : John Wiley & Sons
Release : 2015-12-14
ISBN : 1118416120
Language : En, Es, Fr & De

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Book Description :

Fully revised for the fifth edition, this outstanding reference on bone marrow transplantation is an essential, field-leading resource. Extensive coverage of the field, from the scientific basis for stem-cell transplantation to the future direction of research Combines the knowledge and expertise of over 170 international specialists across 106 chapters Includes new chapters addressing basic science experiments in stem-cell biology, immunology, and tolerance Contains expanded content on the benefits and challenges of transplantation, and analysis of the impact of new therapies to help clinical decision-making Includes a fully searchable Wiley Digital Edition with downloadable figures, linked references, and more References for this new edition are online only, accessible via the Wiley Digital Edition code printed inside the front cover or at www.wiley.com/go/forman/hematopoietic.

Bone Marrow Cells Advances in Research and Application 2011 Edition

Bone Marrow Cells  Advances in Research and Application  2011 Edition Book
Author : Anonim
Publisher : ScholarlyEditions
Release : 2012-01-09
ISBN : 1464923736
Language : En, Es, Fr & De

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Book Description :

Bone Marrow Cells: Advances in Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Bone Marrow Cells. The editors have built Bone Marrow Cells: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Bone Marrow Cells in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Bone Marrow Cells: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Immune Tolerance Post Allogeneic Hematopoietic Cell Transplantation

Immune Tolerance Post Allogeneic Hematopoietic Cell Transplantation Book
Author : Dominik Schneidawind,Everett Meyer
Publisher : Frontiers Media SA
Release : 2020-05-22
ISBN : 2889637204
Language : En, Es, Fr & De

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Book Description :

Download Immune Tolerance Post Allogeneic Hematopoietic Cell Transplantation book written by Dominik Schneidawind,Everett Meyer, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Hematopoietic Stem Cell Transplantation for the Pediatric Hematologist Oncologist

Hematopoietic Stem Cell Transplantation for the Pediatric Hematologist Oncologist Book
Author : Valerie I. Brown
Publisher : Springer
Release : 2017-12-22
ISBN : 3319631462
Language : En, Es, Fr & De

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Book Description :

This volume provides a comprehensive and state-of-the-art review on pediatric hematopoietic stem cell transplantation (HSCT). The book covers such topics as graft versus host disease (GVHD), HSC mobilization, stem cell selection, and HSCT-relevant laboratory assays and techniques. The text is specially formatted so that the scientific basis of HSCT and ethical considerations are integrated into the relevant clinical framework. Each chapter also includes diagrams, illustrations, and tables that summarize key points and concepts that can be used as a quick visual reference for the reader. Written by experts in the field, Hematopoietic Stem Cell Transplantation for the Pediatric Hematologist/Oncologist is a valuable resource on pediatric HSCT suited for pediatric hematologists-oncologists, fellows, advanced practitioners, clinical nurses, and other referring physicians.

Advances in Allogeneic Hematopoietic Stem Cell Transplantation

Advances in Allogeneic Hematopoietic Stem Cell Transplantation Book
Author : Richard K. Burt,Mary M. Brush
Publisher : Springer
Release : 2012-11-28
ISBN : 1461549876
Language : En, Es, Fr & De

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Book Description :

The field of hematopoietic stem cell transplantation is rapidly evolving. Realization that hematopoietic stem cells give rise to the immune compartment has resulted in clinical trials of hematopoietic stem cell transplantation for patients with autoimmune diseases. Allogeneic hematopoietic transplants are a form of adoptive immunotherapy resulting in beneficial graft versus tumor effects. Large numbers of hematopoietic cells can be collected with ease. Therefore, a renewable source of cells for ex vivo genetic manipulations is readily available. Multiple trials combining hematopoietic transplants and gene therapy are in progress. One such application is the infusion of allogeneic lymphocytes containing a suicide gene to abort graft versus host disease. Hematopoietic stem cell transplantation is in reality the clinical and practical application of cellular therapy. Hematopoietic transplant physicians are by design or by practical application evolving into cell and gene therapy specialists. The excitement and enthusiasm in hematopoietic transplantation is that it offers a door to the future. A future not of drugs or titrating poisonous chemotherapy but rather of cellular and gene therapy. 1 ALLOGENEIC PERIPHERAL BLOOD STEM CELL TRANSPLANTATION FOR HEMATOLOGIC DISEASES Martin Korbling University o/Texas MD. Anderson Cancer Center, Houston, Texas 77030 INTRODUCTION Circulating hematopoietic stem cells have emerged as an alternative to bone marrow (BM) stem cells for allografting. For many years the reconstitutive potential of circulating stem cells was questioned; peripheral blood stem cells (PBSC) were even characterized a waste product (1).

Stem Cells in Clinical Practice and Tissue Engineering

Stem Cells in Clinical Practice and Tissue Engineering Book
Author : Rakesh Sharma
Publisher : BoD – Books on Demand
Release : 2018-05-02
ISBN : 1789230101
Language : En, Es, Fr & De

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Book Description :

Stem Cells in Clinical Practice and Tissue Engineering is a concise book on applied methods of stem cell differentiation and optimization using tissue engineering methods. These methods offer immediate use in clinical regenerative medicine. The present volume will serve the purpose of applied stem cell differentiation optimization methods in clinical research projects, as well as be useful to relatively experienced stem cell scientists and clinicians who might wish to develop their stem cell clinical centers or research labs further. Chapters are arranged in the order of basic concepts of stem cell differentiation, clinical applications of pluripotent stem cells in skin, cardiac, bone, dental, obesity centers, followed by tissue engineering, new materials used, and overall evaluation with their permitted legal status.

Stem Cell Therapy for Autoimmune Disease

Stem Cell Therapy for Autoimmune Disease Book
Author : Richard K. Burt
Publisher : CRC Press
Release : 2019-11-11
ISBN : 1000716856
Language : En, Es, Fr & De

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Book Description :

Stem cell transplantation may be complicated by treatment-related mortality and like the immune system that it regenerates has equal potential to either create and preserve or destroy. The dual nature that defines stem cells is differentiation that ultimately leads to death and self-renewal, which leads to immortality. What types of stem cells are there? How are they collected? What are their attributes and characteristics? This textbook devotes many chapters to familiarize the reader with the basic science, clinical aspects, and new questions being raised in the field of stem cell biology. Blood stem cells for tolerance and tissue regeneration are a rapidly developing research and clinical field that is being applied to autoimmune diseases. In clinical trials, autologous hematopoietic (blood) stem cells are being used to reduce the cytopenic interval following intense immune suppressive transplant regimens. While as yet not delineated, some possible mechanisms and pathways leading to tolerance after hematopoietic stem cell transplantation are suggested in these chapters. Tissue regeneration from blood stem cells is also suggested by animal experiments on stem cell plasticity or metamoirosis (i.e., change in fate) as described within this textbook. Ongoing early clinical trials on tissue regeneration from blood stem cells are described in the chapter on stem cell therapy for cardiac and peripheral vascular disease. Whether autologous hematopoietic stem cells, through the process of mobilization and reinfusion, may be manipulated to contribute to tissue repair in autoimmune diseases is a future area for translational research.

Immune Reconstitution After Allogeneic Hematopoietic Stem Cell Transplantation

Immune Reconstitution After Allogeneic Hematopoietic Stem Cell Transplantation Book
Author : Brigitta Omazic
Publisher : Unknown
Release : 2004
ISBN : 9789171401175
Language : En, Es, Fr & De

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Book Description :

Download Immune Reconstitution After Allogeneic Hematopoietic Stem Cell Transplantation book written by Brigitta Omazic, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Novel Immunological Biomarkers for Allogeneic HSCT Outcome

Novel Immunological Biomarkers for Allogeneic HSCT Outcome Book
Author : Raffaella Greco,Fabio Ciceri,Jacopo Peccatori,John Andrew Snowden,Francesca Bonifazi
Publisher : Frontiers Media SA
Release : 2021-05-03
ISBN : 2889667340
Language : En, Es, Fr & De

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Book Description :

Download Novel Immunological Biomarkers for Allogeneic HSCT Outcome book written by Raffaella Greco,Fabio Ciceri,Jacopo Peccatori,John Andrew Snowden,Francesca Bonifazi, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Bone Marrow Cells Advances in Research and Application 2013 Edition

Bone Marrow Cells   Advances in Research and Application  2013 Edition Book
Author : Anonim
Publisher : ScholarlyEditions
Release : 2013-06-21
ISBN : 148168583X
Language : En, Es, Fr & De

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Book Description :

Bone Marrow Cells—Advances in Research and Application: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Monocytes. The editors have built Bone Marrow Cells—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Monocytes in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Bone Marrow Cells—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.