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Identification And Quantification Of Drugs Metabolites Drug Metabolizing Enzymes And Transporters

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Identification and Quantification of Drugs Metabolites Drug Metabolizing Enzymes and Transporters

Identification and Quantification of Drugs  Metabolites  Drug Metabolizing Enzymes  and Transporters Book
Author : Shuguang Ma,Swapan Chowdhury
Publisher : Elsevier
Release : 2020-07-09
ISBN : 0128200197
Language : En, Es, Fr & De

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Book Description :

Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters, Second Edition, is completely updated to provide an overview of the last decade’s numerous advances in analytical technologies for detection and quantification of drugs, metabolites, and biomarkers. This new edition goes beyond LC-MS and features all-new chapters on how to evaluate drug absorption, distribution, metabolism, and excretion, potential for hepatic and renal toxicity, immunogenicity of biotherapeutics and translational tools for predicting human dosage, safety and efficacy of small molecules and biologics. This book will be an important handbook and desk reference for pharmacologists, toxicologists, clinical scientists, and students interested in the fields of pharmacology, biochemistry, and drug metabolism. Four sections in the book with 24 chapters give readers an overview of state-of-the-art techniques for identifying and quantifying drugs, metabolites and biomarkers, including a chapter on new approaches for quantification of enzymes and transporters in different tissues Focuses on the role of drug metabolism enzymes, transporters in disposition and drug-drug interactions, as well as strategies for evaluating drug metabolism and safety using advanced liver and kidney models. Discussions on immunogenicity risks of biologics and their evaluation methods have been included Includes several chapters on advanced translational sciences to predict human dosage, pharmacokinetics and efficacy for small molecules and biotherapeutics All chapters are written by experts with a wide range of practical experience from the industry and academia

Identification and Quantification of Drugs Metabolites and Metabolizing Enzymes by LC MS

Identification and Quantification of Drugs  Metabolites and Metabolizing Enzymes by LC MS Book
Author : Swapan Chowdhury
Publisher : Elsevier
Release : 2005-11-04
ISBN : 9780080456065
Language : En, Es, Fr & De

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Book Description :

As new techniques of transferring from liquid to gas phase and measuring masses of drug molecules and metabolites become more prevalent, so do the technical challenges of putting these techniques into proper use, as well as the task of consolidating emerging applications. Identification and Quantification of Drugs, Metabolites and Metabolizing Enzymes by LC-MS, Volume 6 fills the gap in the lack of presently available literature by providing a critical review in the current use of liquid chromatography-mass spectrometry (LC-MS) in drug discovery and development. With chapters written by experts with a wide range of practical experience from the pharmaceutical industry, emphasis is placed on techniques and applications. The book also includes chapters on how to utilize LC-MS instrumentation for current drug metabolism problems. This book is intended for those beginning to use LC-MS for drug metabolism studies as well as for those considered advanced practitioners. * Introduces readers to the practical applications of modern liquid chromatography-mass spectrometry (LC-MS) in a wide range of drug metabolism studies· * Provides a comprehensive description of different forms of metabolites, with detailed discussion on the wide range of methodologies used to identify them * Highlights problems associated with drug quantification and offers practical solutions

Biodegradation and Biodeterioration at the Nanoscale

Biodegradation and Biodeterioration at the Nanoscale Book
Author : Hafiz M.N. Iqbal,Muhammad Bilal,Tuan Anh Nguyen,Ghulam Yasin
Publisher : Elsevier
Release : 2021-10-08
ISBN : 0128241799
Language : En, Es, Fr & De

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Book Description :

Biodegradation and Biodeterioration at the Nanoscale describes the biodegradation and biodeterioration of materials in the presence of nanomaterials. The book's chapters focus on the basic principles, action mechanisms and promising applications of advanced nanomaterials, along with their integration with biotechnological processes for controlled degradation and deterioration of materials. In addition, the current research indications, positive or negative environmental impacts, legislation and future directions are also discussed. This book is an important reference source for researchers, engineers and scientists working in environmental remediation, biotechnology, materials science, corrosion and nanotechnology. Provides detailed coverage on how nano-biomaterials degrade and deteriorate Compares how different types of bionanomaterials decompose Explains how the priorities of bionanomaterials affect their deterioration rate

Cerebral endothelial and glial cells are more than bricks in the Great Wall of the brain insights into the way the blood brain barrier actually works Celebrating the centenary of Goldman s experiments

Cerebral endothelial and glial cells are more than bricks in the Great Wall of the brain  insights into the way the blood brain barrier actually works  Celebrating the centenary of Goldman   s experiments  Book
Author : Elena García-Martín,George E. Barreto,José A. G. Agúndez,Rubem C. A. Guedes,Ramon Santos El-Bachá
Publisher : Frontiers Media SA
Release : 2015-07-02
ISBN : 2889195724
Language : En, Es, Fr & De

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Book Description :

When Ehrlich discovered the first evidence of the blood-brain barrier in 1885, he probably did not perceive the Great Wall that remained hidden from consciousness inside the central nervous system. Ehrlich had observed that acidic vital dyes did not stain the brain if they were injected into the blood stream. A century ago (1913), Goldman showed that the injection of trypan blue in the cerebrospinal fluid stained only the brain, but not the other organs. For almost a century it was thought that the blood-brain barrier (BBB) consisted in a physical barrier, resulting from the restricted permeability of the cerebral endothelial cell layer, as they are joined by tight junctions. However, as scientists are always looking for news in what is already discovered, in the end of the 20th century we had evidences that cerebral endothelial and glial cells express several drug metabolizing enzymes consisting in a second protection system: a metabolic barrier. Furthermore, the drugs and their metabolites must overcome the activity of several multidrug resistance proteins that function as ATP-dependent efflux pumps, consisting in the third line of defence: the active barrier. Therefore, the way the BBB actually works should be better explained. Several endogenous compounds, as well as xenobiotics, may be activated by enzymes of the metabolic barrier, generating reactive oxygen species that could damage neurons. Therefore, endothelial and glial cells possess endogenous protecting compounds and enzymes against oxidants, consisting in an antioxidant barrier. When all these systems fail, glial cells, mainly microglia, secrete cytokines in an attempt to crosstalk with defence cells asking for help, which consists in an immune barrier. In cerebral regions that are devoid of the physical barrier, such as circumventricular organs, the metabolic, active, antioxidant and immune barriers are reinforced. It is important to understand how cells involved in the BBB interact with one another and the dynamic mechanisms of their functions. This Research Topic published in this e-Book considers recent highlights in BBB structure, cell and molecular biology, biotransformation, physiology, pathology, pharmacology, immunology and how these basic knowledges can be applied in drug discovery and clinical researches, rewriting what is already written, and paving the way that goes to the Great Wall in the Frontiers of the Brain in this new century that is just beginning.

Early Drug Development

Early Drug Development Book
Author : Mitchell N. Cayen
Publisher : John Wiley & Sons
Release : 2011-02-25
ISBN : 9781118035207
Language : En, Es, Fr & De

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Book Description :

The focus of early drug development has been the submission of an Investigational New Drug application to regulatory agencies. Early Drug Development: Strategies and Routes to First-in-Human Trials guides drug development organizations in preparing and submitting an Investigational New Drug (IND) application. By explaining the nuts and bolts of preclinical development activities and their interplay in effectively identifying successful clinical candidates, the book helps pharmaceutical scientists determine what types of discovery and preclinical research studies are needed in order to support a submission to regulatory agencies.

Drug Metabolism in Drug Design and Development

Drug Metabolism in Drug Design and Development Book
Author : Donglu Zhang,Mingshe Zhu,William G. Humphreys
Publisher : John Wiley & Sons
Release : 2007-11-16
ISBN : 9780470191682
Language : En, Es, Fr & De

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Book Description :

The essentials of drug metabolism vital to developing new therapeutic entities Information on the metabolism and disposition of candidate drugs is a critical part of all aspects of the drug discovery and development process. Drug metabolism, as practiced in the pharmaceutical industry today, is a complex, multidisciplinary field that requires knowledge of sophisticated analytical technologies and expertise in mechanistic and kinetic enzymology, organic reaction mechanism, pharmacokinetic analysis, animal physiology, basic chemical toxicology, preclinical pharmacology, and molecular biology. With chapters contributed by experts in their specific areas, this reference covers: * Basic concepts of drug metabolism * The role of drug metabolism in the pharmaceutical industry * Analytical techniques in drug metabolism * Common experimental approaches and protocols Drug Metabolism in Drug Design and Development emphasizes practical considerations such as the data needed, the experiments and analytical methods typically employed, and the interpretation and application of data. Chapters highlight facts, common protocols, detailed experimental designs, applications, and limitations of techniques. This is a comprehensive, hands-on reference for drug metabolism researchers as well as other professionals involved in pre-clinical drug discovery and development.

Handbook of Radioactivity Analysis

Handbook of Radioactivity Analysis Book
Author : Michael F. L'Annunziata
Publisher : Academic Press
Release : 2020-03-07
ISBN : 0128143967
Language : En, Es, Fr & De

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Book Description :

Handbook of Radioactivity Analysis: Radiation Physics and Detectors, Volume One, and Radioanalytical Applications, Volume Two, Fourth Edition, constitute an authoritative reference on the principles, practical techniques and procedures for the accurate measurement of radioactivity - everything from the very low levels encountered in the environment, to higher levels measured in radioisotope research, clinical laboratories, biological sciences, radionuclide standardization, nuclear medicine, nuclear power, and fuel cycle facilities, and in the implementation of nuclear forensic analysis and nuclear safeguards. It includes sample preparation techniques for all types of matrices found in the environment, including soil, water, air, plant matter and animal tissue, and surface swipes. Users will find the latest advances in the applications of radioactivity analysis across various fields, including environmental monitoring, radiochemical standardization, high-resolution beta imaging, automated radiochemical separation, nuclear forensics, and more. Spans two volumes, Radiation Physics and Detectors and Radioanalytical Applications Includes a new chapter on the analysis of environmental radionuclides Provides the latest advances in the applications of liquid and solid scintillation analysis, alpha- and gamma spectrometry, mass spectrometric analysis, Cherenkov counting, flow-cell radionuclide analysis, radionuclide standardization, aerosol analysis, high-resolution beta imaging techniques, analytical techniques in nuclear forensics, and nuclear safeguards Describes the timesaving techniques of computer-controlled automatic separation and activity analysis of radionuclides Provides an extensive table of the radiation characteristics of most radionuclides of interest for the radioanalytical chemist

Handbook of Radioactivity Analysis

Handbook of Radioactivity Analysis Book
Author : Michael F. L'Annunziata
Publisher : Academic Press
Release : 2020-03-03
ISBN : 0128143983
Language : En, Es, Fr & De

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Book Description :

Handbook of Radioactivity Analysis: Radiation Physics and Detectors, Volume One, and Radioanalytical Applications, Volume Two, Fourth Edition, is an authoritative reference on the principles, practical techniques and procedures for the accurate measurement of radioactivity - everything from the very low levels encountered in the environment, to higher levels measured in radioisotope research, clinical laboratories, biological sciences, radionuclide standardization, nuclear medicine, nuclear power, and fuel cycle facilities, and in the implementation of nuclear forensic analysis and nuclear safeguards. It includes sample preparation techniques for all types of matrices found in the environment, including soil, water, air, plant matter and animal tissue, and surface swipes. Users will find a detailed discussion of our current understanding of the atomic nucleus, nuclear stability and decay, nuclear radiation, and the interaction of radiation with matter relating to the best methods for radionuclide detection and measurement. Spans two volumes, Radiation Physics and Detectors and Radioanalytical Applications Includes a much-expanded treatment of calculations required in the measurement of radionuclide decay, energy of decay, nuclear reactions, radiation attenuation, nuclear recoil, cosmic radiation, and synchrotron radiation Includes the latest advances in liquid and solid scintillation analysis, alpha- and gamma spectrometry, mass spectrometric analysis, gas ionization and nuclear track analysis, and neutron detection and measurement Covers high-sample-throughput microplate techniques and multi-detector assay methods

Psychopharmacology Abstracts

Psychopharmacology Abstracts Book
Author : Anonim
Publisher : Unknown
Release : 1976
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Psychopharmacology Abstracts book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Transporters and Drug Metabolizing Enzymes in Drug Toxicity

Transporters and Drug Metabolizing Enzymes in Drug Toxicity Book
Author : Albert P. Li
Publisher : John Wiley & Sons
Release : 2021-06-29
ISBN : 1119170990
Language : En, Es, Fr & De

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Book Description :

This book provides a comprehensive and up-to-date coverage of the relationship between drug metabolism enzymes and transporters on drug toxicity, along with methods to investigate their role on adverse drug reactions. Unites both the metabolism and transporter components of drug toxicity – two aspects not normally connected and the latter often neglected Familiarizes readers with the mechanism and species differences in drug metabolizing enzymes and transporters Discusses promising approaches to accurately predict human drug toxicity via the incorporation of human drug metabolism in toxicity evaluation

International Pharmaceutical Product Registration Second Edition

International Pharmaceutical Product Registration  Second Edition Book
Author : Anthony C. Cartwright,Brian R. Matthews
Publisher : CRC Press
Release : 2016-04-19
ISBN : 1420081837
Language : En, Es, Fr & De

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Book Description :

Discover the latest ICH news from international experts in the pharmaceutical industry, academia, and regulatory bodies. The recent International Conference on Harmonisation (ICH) revisions of regulatory requirements for quality, nonclinical, and clinical pharmaceutical product registration are the focus of this timely update. This cutting-edge resource includes the major headings in the modular structure of the Common Technical Document (CTD), which is now the agreed format for product information submission. The format, specification, and technical requirements of the e-CTD, the electronic version of CTD, are also thoroughly discussed. The book is organized into six highly practical segments: Part I: CTD, eCTD, Module 1, and Environmental Risk Assessment Part II: CTD Summaries Part III: Quality Topics Part IV: Nonclinical Topics Part V: Clinical Topics Part VI: Other Topics (including drug-device combination products) This text is a must-have for those in the pharmaceutical industry determining regulatory requirements for the major world markets in Europe, the US, Canada, and Japan.

Mass Spectrometry in Drug Metabolism and Disposition

Mass Spectrometry in Drug Metabolism and Disposition Book
Author : Mike S. Lee,Mingshe Zhu
Publisher : John Wiley & Sons
Release : 2011-03-16
ISBN : 9780470934692
Language : En, Es, Fr & De

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Book Description :

This book examines the background, industrial context, process, analytical methodology, and technology of metabolite identification. It emphasizes the applications of metabolite identification in drug research. While primarily a textbook, the book also functions as a comprehensive reference to those in the industry. The authors have worked closely together and combine complementary backgrounds to bring technical and cultural awareness to this very important endeavor while serving to address needs within academia and industry It also contains a variety of problem sets following specific sections in the text.

Cumulated Index Medicus

Cumulated Index Medicus Book
Author : Anonim
Publisher : Unknown
Release : 1980
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Cumulated Index Medicus book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Goodman and Gilman s The Pharmacological Basis of Therapeutics Twelfth Edition

Goodman and Gilman s The Pharmacological Basis of Therapeutics  Twelfth Edition Book
Author : Laurence Brunton,Bruce Chabner,Bjorn Knollman
Publisher : McGraw Hill Professional
Release : 2010-12-20
ISBN : 0071624422
Language : En, Es, Fr & De

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Book Description :

The landmark text in medical pharmacology is now in full color Includes DVD with image bank A Doody's Core Title ESSENTIAL PURCHASE for 2011! 4 STAR DOODY'S REVIEW! "This 12th edition of the most authoritative book in pharmacology is the best both in content and physical appearance....This edition of Goodman & Gilman's continues to be the most authoritative and widely used resource bridging the discipline of pharmacology with therapeutics. Moreover, readers will find this edition to be substantially improved from past editions in both content and physical appearance."--Doody's Review Service The most universally respected and read medical text in all of pharmacology, Goodman & Gilman’s The Pharmacological Basis of Therapeutics represents the pinnacle of authority and accuracy in describing the actions and uses of therapeutic agents in relation to physiology and pathophysiology. Goodman & Gilman’s careful balance of basic science and clinical application has guided thousands of practitioners and students to a clear understanding of the drugs essential to preventing, diagnosing, and treating disease. Enriched by a new full-color presentation and updated to reflect all critical new developments in drug action and drug-disease interaction, the twelfth edition includes more than 440 color illustrations depicting key principles and actions of specific pathways and therapeutic agents. The companion DVD includes all the images and tables in the text along with narrated animations. Goodman & Gilman’s The Pharmacological Basis of Therapeutics, 12e is divided into nine sections, covering: General Principles Neuropharmacology Modulation of Cardiovascular Function Inflammation, Immunomodulation, and Hematopoiesis Endocrine Pharmacology Gastrointestinal Pharmacology Chemotherapy of Infectious Disease Chemotherapy of Neoplastic Diseases Special Systems Pharmacology More than a textbook, Goodman & Gilman's is a working template for the effective and rational prescribing of drugs in daily practice.

Goodman and Gilman s The Pharmacological Basis of Therapeutics 13th Edition

Goodman and Gilman s The Pharmacological Basis of Therapeutics  13th Edition Book
Author : Laurence Brunton,Bjorn Knollman,Randa Hilal-Dandan
Publisher : McGraw Hill Professional
Release : 2017-10-26
ISBN : 1259584747
Language : En, Es, Fr & De

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Book Description :

The gold-standard of pharmacology texts – completely updated to reflect the latest research and developments A Doody’s Core Title for 2019! Goodman & Gilman’s: The Pharmacological Basis of Therapeutics, Thirteenth Edition represents the pinnacle of authority and accuracy in describing the actions and uses of therapeutic agents in relation to physiology and pathophysiology. Goodman & Gilman’s careful balance of basic science and clinical application has guided thousands of practitioners and students to a clear understanding of the drugs essential to preventing, diagnosing, and treating disease. The Thirteenth Edition includes more than 500 color illustrations, with many new figures emphasizing mechanisms of drug action. More than 30 new contributors have added to this edition, while the focus on basic principles is undiminished. This edition is enhanced by timely new content: •NEW chapters including Treatment of Pulmonary Arterial Hypertension, Immunity and Inflammation, Immunoglobulins and Vaccines, and Treatment of Viral Hepatitis •Expanded coverage of cardiovascular disease, with separate chapters on myocardial ischemia, hypertension, and heart failure •Increased emphasis on cellular signaling pathways involved in drug action •Summary tables at the end of each chapter that organize drugs discussed in that chapter into relevant categories and detail therapeutic usage, clinical pharmacology, and tips •Chapter Content Outlines at the beginning of each chapter •Abbreviation boxes in every chapter to easily identify the abbreviations appearing in that chapter More than a textbook, Goodman & Gilman’s is a working template for the effective and rational prescribing of drugs in daily practice.

Psychopharmacology Abstracts

Psychopharmacology Abstracts Book
Author : Anonim
Publisher : Unknown
Release : 1976
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Psychopharmacology Abstracts book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Transporters in Drug Development

Transporters in Drug Development Book
Author : Yuichi Sugiyama,Bente Steffansen
Publisher : Springer Science & Business Media
Release : 2013-09-16
ISBN : 1461482291
Language : En, Es, Fr & De

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Book Description :

Transporters in Drug Development examines how membrane transporters can be dealt with in academic–industrial drug discovery and pharmaceutical development as well as from a regulatory perspective. The book describes methods and examples of in vitro characterization of single transporters in the intestines, liver and kidneys as well as characterization of substrate overlap between various transporters. Furthermore, probes and biomarkers are suggested for studies of the transporters’ impact on the pharmacokinetics of drug substrates/candidates interacting on transporters. The challenges of translating in vitro observed interaction of transporters into in vivo relevance are explored, and the book highlights perspectives of applying targeted proteomics and mechanistic modeling in this process.

Preclinical Development Handbook

Preclinical Development Handbook Book
Author : Shayne Cox Gad
Publisher : John Wiley & Sons
Release : 2008-03-21
ISBN : 0470249021
Language : En, Es, Fr & De

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Book Description :

A clear, straightforward resource to guide you through preclinical drug development Following this book's step-by-step guidance, you can successfully initiate and complete critical phases of preclinical drug development. The book serves as a basic, comprehensive reference to prioritizing and optimizing leads, dose formulation, ADME, pharmacokinetics, modeling, and regulations. This authoritative, easy-to-use resource covers all the issues that need to be considered and provides detailed instructions for current methods and techniques. Each chapter is written by one or more leading experts in the field. These authors, representing the many disciplines involved in preclinical toxicology screening and testing, give you the tools needed to apply an effective multidisciplinary approach. The editor has carefully reviewed all the chapters to ensure that each one is thorough, accurate, and clear. Among the key topics covered are: * Modeling and informatics in drug design * Bioanalytical chemistry * Absorption of drugs after oral administration * Transporter interactions in the ADME pathway of drugs * Metabolism kinetics * Mechanisms and consequences of drug-drug interactions Each chapter offers a full exploration of problems that may be encountered and their solutions. The authors also set forth the limitations of various methods and techniques used in determining the safety and efficacy of a drug during the preclinical stage. This publication should be readily accessible to all pharmaceutical scientists involved in preclinical testing, enabling them to perform and document preclinical safety tests to meet all FDA requirements before clinical trials may begin.

Drug Metabolism Pharmacokinetics and Bioanalysis

Drug Metabolism  Pharmacokinetics and Bioanalysis Book
Author : Hye Suk Lee,Kwang-Hyeon Liu
Publisher : MDPI
Release : 2019-06-12
ISBN : 3038979163
Language : En, Es, Fr & De

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Book Description :

Drug metabolism/pharmacokinetics and drug interaction studies have been extensively carried out in order to secure the druggability and safety of new chemical entities throughout the development of new drugs. Recently, drug metabolism and transport by phase II drug metabolizing enzymes and drug transporters, respectively, as well as phase I drug metabolizing enzymes, have been studied. A combination of biochemical advances in the function and regulation of drug metabolizing enzymes and automated analytical technologies are revolutionizing drug metabolism research. There are also potential drug–drug interactions with co-administered drugs due to inhibition and/or induction of drug metabolic enzymes and drug transporters. In addition, drug interaction studies have been actively performed to develop substrate cocktails that do not interfere with each other and a simultaneous analytical method of substrate drugs and their metabolites using a tandem mass spectrometer. This Special Issue has the aim of highlighting current progress in drug metabolism/pharmacokinetics, drug interactions, and bioanalysis.

Handbook of Drug Metabolism Third Edition

Handbook of Drug Metabolism  Third Edition Book
Author : Paul G. Pearson,Larry C. Wienkers
Publisher : CRC Press
Release : 2019-05-20
ISBN : 1482262045
Language : En, Es, Fr & De

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Book Description :

This book continues to be the definitive reference on drug metabolism with an emphasis on new scientific and regulatory developments. It has been updated based on developments that have occurred in the last 5 years, with new chapters on large molecules disposition, stereo-selectivity in drug metabolism, drug transporters and metabolic activation of drugs. Some chapters have been prepared by new authors who have emerged as subject area experts in the decade that has passed since publication of the first edition.