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Hypothalamus And Neuroendocrine Disorders

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The Human Hypothalamus

The Human Hypothalamus Book
Author : Dick F. Swaab,Ruud M. Buijs,Paul J. Lucassen,Ahmad Salehi,Felix Kreier
Publisher : Elsevier
Release : 2021-07-04
ISBN : 0128206845
Language : En, Es, Fr & De

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Book Description :

The Human Hypothalamus: Neuroendocrine Disorders, Volume 181 in the Handbook of Clinical Neurology series, provides comprehensive summaries of recent research on the brain and nervous system as they relate to clinical neurology. This volume summarizes the role of the hypothalamus in neuroendocrine disorders, identifying the mechanism of action, disorder etiology, and best practices for assessment and treatment. Disorders covered include pituitary hypothalamic disorders of development and growth, hypothalamic tumor related disorders, hypothalamic autoimmune disorders and infection, disorders of vasopressin, water and sodium homeostasis, eating disorders, and gonadotropic hormone regulation disorders. Discusses the importance of the hypothalamus in human growth and development Reviews hypothalamic related tumors, as well as pituitary, autoimmune, vasopressin and hormone regulation disorders Includes metabolic and eating disorders Identifies mechanisms of disease action and etiology Provides best practice information for assessment and treatment

Clinical Neuroendocrinology

Clinical Neuroendocrinology Book
Author : Joy Foster
Publisher : American Medical Publishers
Release : 2021-11-16
ISBN : 9781639271115
Language : En, Es, Fr & De

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Book Description :

Neuroendocrinology is the domain of biology that is concerned with the study of the interaction between the nervous system and the endocrine system. In the process of neuroendocrine integration, the nervous and endocrine systems act together in order to control the physiological processes of the human body. For understanding and treating neurobiological brain disorders, neuroendocrinology is used as an essential part. The neuroendocrine system is the tool through which the hypothalamus maintains homeostasis that helps in regulating metabolism, eating, reproduction, osmolarity, blood pressure and drinking behavior. The four main neuroendocrine systems are hypothalamic-pituitary-adrenal axis, hypothalamic-pituitary-thyroid axis, hypothalamic-pituitary-gonadal axis and hypothalamic-neurohypophyseal system. This book contains some path-breaking studies in the field of neuroendocrinology. It strives to provide a fair idea about this discipline and to help develop a better understanding of the latest advances within this field. This book is appropriate for students seeking detailed information in this area as well as for experts.

An Introduction to Neuroendocrinology

An Introduction to Neuroendocrinology Book
Author : Michael Wilkinson,Richard E. Brown
Publisher : Cambridge University Press
Release : 2015-06-04
ISBN : 1316297950
Language : En, Es, Fr & De

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Book Description :

How does the brain regulate sexual behavior, or control our body weight? How do we cope with stress? Addressing these questions and many more besides, this thoroughly revised new edition reflects the significant advances that have been made in the study of neuroendocrinology over the last twenty years. The text examines the importance of the hypothalamus in regulating hormone secretion from the endocrine glands, describing novel sites of hormone release including bone, heart, skeletal muscle and liver. The role of steroid hormone, neurotransmitter and peptide receptors, and the molecular responses of target tissues, is integrated into the discussion of the neuroendocrine brain, especially through changes in gene expression. Particular attention is attached to neuropeptides, including their profound influence on behavior. Complete with new full-color figures throughout, along with review and essay questions for each chapter, this is an ideal resource for undergraduate and graduate students of neuroscience, psychology, biology and physiology.

Human Hypothalamus Basic and Clinical Aspects

Human Hypothalamus  Basic and Clinical Aspects Book
Author : Dick F. Swaab
Publisher : Elsevier
Release : 2003-12-29
ISBN : 9780444513571
Language : En, Es, Fr & De

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Book Description :

As the human hypothalamus has traditionally been considered part of the neuroendocrine system, it has been of little interest to neurologists. This volume creates renewed interest in the subject, highlighting groundbreaking research that links this complex part of the human brain to a variety of neurological and psychological disorders. Clinicians, researchers, and practitioners from a variety of medical fields will find this to be a comprehensive presentation of new research that applies to a variety of disorders, including their origin, diagnosis, and treatment. From groundbreaking discussions that link the human hypothalamus to attention deficits in the dementias, to its role in disorders such as narcolepsy and certain epilepsies, users will find this volume to be an invaluable resource for research and patient care. Specific information on topics including depression, eating disorders, aggression, and mental retardation are included, giving those in the field of neurology, psychiatry, endocrinology, and pediatrics a comprehensive understanding on how the human hypothalamus is related to patient disorders in these fields. * A comprehensive accounting of groundbreaking new research regarding the human hypothalamus * New insights on the hypothalamus and its role in disorders, including dementias, epilepsies, and associated psychiatric diseases * A greater understanding of how the human hypothalamus impacts research and treatment protocols in a variety of fields, including neurology, endocrinology, and psychology

Endocrinology Adult and Pediatric Neuroendocrinology and The Pituitary Gland E Book

Endocrinology Adult and Pediatric  Neuroendocrinology and The Pituitary Gland E Book Book
Author : Shlomo Melmed,J. Larry Jameson,Leslie J. De Groot
Publisher : Elsevier Health Sciences
Release : 2013-05-09
ISBN : 0323221556
Language : En, Es, Fr & De

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Book Description :

Apply the latest advances in management of neuroendocrine and pituitary disorders with the Endocrinology: Adult and Pediatric: Neuroendocrinology and The Pituitary Gland eBook! Brought to you by the same expert endocrinologists responsible for the highly acclaimed two-volume Endocrinology clinical reference, this endocrinology eBook puts all of the newest latest know-how of the Pituitary Gland and Neuroendocrinology at your fingertips, instantly accessible on your favorite eReader - so you can offer your patients the best care. Stay abreast of the newest knowledge on neuroendocrinology and the pituitary gland, including our most recent understanding of the fundamental cellular and physiologic functions of the neuroendocrine system, mechanisms underlying clinical disorders, and approaches to managing patients harboring disorders of the hypothalamus and pituitary gland. Approach any subject either by specific gland or through a discussion of multi-hormonal integration of endocrine function, as led by the "master conductor of the endocrine orchestra," the pituitary gland. Gain a state-of-the-art understanding of comprehensive descriptors, integrating endocrine cell ontogeny, hormonal control of growth and maturation processes, and childhood and young adult pathophysiology with maturation and aging processes. Count on all the authority that has made Endocrinology, 6th Edition, edited by Drs. Jameson and DeGroot, the go-to medical reference for endocrinologists worldwide. Make the best clinical endocrinology decisions with an enhanced emphasis on evidence-based practice in conjunction with expert opinion. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Compatible with Kindle®, nook®, and other popular devices.

Human Hypothalamus Basic and Clinical Aspects

Human Hypothalamus  Basic and Clinical Aspects Book
Author : Dick F. Swaab
Publisher : Elsevier
Release : 2003-12-29
ISBN : 9780444513571
Language : En, Es, Fr & De

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Book Description :

As the human hypothalamus has traditionally been considered part of the neuroendocrine system, it has been of little interest to neurologists. This volume creates renewed interest in the subject, highlighting groundbreaking research that links this complex part of the human brain to a variety of neurological and psychological disorders. Clinicians, researchers, and practitioners from a variety of medical fields will find this to be a comprehensive presentation of new research that applies to a variety of disorders, including their origin, diagnosis, and treatment. From groundbreaking discussions that link the human hypothalamus to attention deficits in the dementias, to its role in disorders such as narcolepsy and certain epilepsies, users will find this volume to be an invaluable resource for research and patient care. Specific information on topics including depression, eating disorders, aggression, and mental retardation are included, giving those in the field of neurology, psychiatry, endocrinology, and pediatrics a comprehensive understanding on how the human hypothalamus is related to patient disorders in these fields. * A comprehensive accounting of groundbreaking new research regarding the human hypothalamus * New insights on the hypothalamus and its role in disorders, including dementias, epilepsies, and associated psychiatric diseases * A greater understanding of how the human hypothalamus impacts research and treatment protocols in a variety of fields, including neurology, endocrinology, and psychology

Human Hypothalamus Basic and Clinical Aspects Part II

Human Hypothalamus  Basic and Clinical Aspects  Part II Book
Author : Dick F. Swaab
Publisher : Elsevier
Release : 2004-01-13
ISBN : 9780444514905
Language : En, Es, Fr & De

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Book Description :

This volume provides a comprehensive understanding of the human hypothalamus, an extremely complex structure that consists of a large number of very different functional units. It approaches the subject in a way that has not historically existed in standard neuropathological investigations of the human brain. As the hypothalamus was traditionally considered to be a neuroendocrine structure, and hence of little interest to neurologists, this volume explores new findings in the field and the value they bring to the field of neurology. New understandings of the role the hypothalamus plays in memory and attention deficits in the dementias, along with greater evidence that the hypothalamus is related to symptoms and signs in both neurological and psychological disorders provide users in the fields of neuroscience, endocrinology, pediatrics, and psychology with a comprehensive resource on which to base new research and exploration. * A new understanding of the role of the human hypothalamus in neurological disorders * Clinical evidence regarding a plethora of neurological disorders and how they relate to the human hypothalamus * A greater understanding of the direct connection between both neurological and psychological disorders and the role of the hypothalamus in these disorders

Corticotropin Releasing Factor

Corticotropin Releasing Factor Book
Author : Derek J. Chadwick,Joan Marsh,Kate Ackrill
Publisher : John Wiley & Sons
Release : 2008-04-30
ISBN : 047051437X
Language : En, Es, Fr & De

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Book Description :

Working on Corticotropin-Releasing Factor in a variety of systems, experts present a coherent depiction of this peptide's role in the control and coordination of the response to stress-inducing situations.

Hormonal and Neuroendocrine Regulation of Energy Balance

Hormonal and Neuroendocrine Regulation of Energy Balance Book
Author : Maria Moreno,Antonia Lanni
Publisher : Frontiers Media SA
Release : 2016-07-18
ISBN : 2889198855
Language : En, Es, Fr & De

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Book Description :

Alteration in adequate energy balance maintenance results in serious disturbances such as obesity and its related metabolic disorders. In Mammals, energy balance is homeostatically controlled through hormonal and neuroendocrine systems which cooperation is based on cross-talk between central and peripheral signals. The hypothalamus as well as peripheral hormones among which adipokines from adipose tissue and thyroid hormones play a crucial role in energy homeostasis. Unraveling the physiological, cellular and molecular mechanisms through which hormonal and neuroendocrine systems regulate energy balance has been a long-standing challenge in biology and is now more necessary when considering the world-wide increasing prevalence of obesity. Indeed, recognizing and understanding the biochemical and nutrient signaling pathways contributing to the nervous and endocrine integration of physiological mechanisms involved in the normal and/or abnormal regulation of energy balance is fundamental also to the development of new, effective, and targeted treatments for obesity. Recent studies have highlighted the role of hypothalamic pro-opiomelanocortin-expressing neurons in the regulation of energy homeostasis by controlling energy expenditure and food intake. This is accomplished through a precise balance of production and degradation of a-melanocyte-stimulating hormone, an anorexigenic neuropeptide which is degraded to an inactive form unable to inhibit food intake by the key enzyme prolyl carboxypeptidase (PRCP), thus suggesting that pharmacologic approaches targeting PRCP may provide a novel and effective option for the management of obesity and its associated metabolic disorders. Indeed, efforts have been made to generate potent, brain-penetrant PRCP inhibitors. Weight loss due to negative energy balance is a goal for obese subjects not always reachable by dietary caloric restriction or increased physical activity. Lipid-lowering therapies have been suggested to have potential benefits, however, the establishment of comprehensive therapeutic strategies is still awaited. Recently, it has been reported that thyroid hormone (TH)- derivatives such as 3,5-diiodothyronine and 3-iodothyronamine possess interesting biological activities, opening new perspectives in thyroid physiology and TH derivatives therapeutic usage. Moreover, several studies, focusing on the interaction between thyroid hormone (TH), the autonomic nervous system and the liver, revealed an important role for the hypothalamus in the differential effects of TH on autonomic outflow to peripheral organs controlling energy balance. This Research Topic aims to give a comprehensive and integrate view of the factors involved in the endocrine and neuroendocrine signaling in energy balance regulation to highlight their involvement into physiological processes and regulatory systems as well as their perturbation during pathological processes.

The Hypothalamus

The Hypothalamus Book
Author : Association for Research in Nervous and Mental Disease
Publisher : Unknown
Release : 1978
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download The Hypothalamus book written by Association for Research in Nervous and Mental Disease, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Human Hypothalamus Basic and Clinical Aspects Part II

Human Hypothalamus  Basic and Clinical Aspects  Part II Book
Author : Dick F. Swaab
Publisher : Elsevier
Release : 2004-01-13
ISBN : 9780444514905
Language : En, Es, Fr & De

GET BOOK

Book Description :

This volume provides a comprehensive understanding of the human hypothalamus, an extremely complex structure that consists of a large number of very different functional units. It approaches the subject in a way that has not historically existed in standard neuropathological investigations of the human brain. As the hypothalamus was traditionally considered to be a neuroendocrine structure, and hence of little interest to neurologists, this volume explores new findings in the field and the value they bring to the field of neurology. New understandings of the role the hypothalamus plays in memory and attention deficits in the dementias, along with greater evidence that the hypothalamus is related to symptoms and signs in both neurological and psychological disorders provide users in the fields of neuroscience, endocrinology, pediatrics, and psychology with a comprehensive resource on which to base new research and exploration. * A new understanding of the role of the human hypothalamus in neurological disorders * Clinical evidence regarding a plethora of neurological disorders and how they relate to the human hypothalamus * A greater understanding of the direct connection between both neurological and psychological disorders and the role of the hypothalamus in these disorders

Disruption of Neuroendocrine Signaling During Cholestatic Liver Disease Pathogenic Role of Bile Acids in the CNS

Disruption of Neuroendocrine Signaling During Cholestatic Liver Disease  Pathogenic Role of Bile Acids in the CNS Book
Author : Matthew Allan Quinn
Publisher : Unknown
Release : 2013
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

ABSTRACT: The hypothalamic-pituitary adrenal (HPA) axis is suppressed during cholestasis, a condition in which bile cannot flow properly in the bile ducts leading to an increase in circulating bile acids. A key pathogenic hallmark of cholestatic liver disease is an outgrowth of the biliary tree. The consequences of a suppressed HPA axis on biliary growth has yet to be determined. We show biliary outgrowth is induced when circulating glucocorticoids are diminished. Bile acids are detergent molecules synthesized in the liver, which also possess signaling properties. The blood brain barrier (BBB) is known to become compromised during the course of liver disease, however the mechanism has yet to be fully elucidated. When bile acids are increased to a pathogenic level in the circulation, the BBB becomes compromised. This is due to a disruption of tight junctions in vascular endothelial cells induced by the detergent properties of bile acids. Once bile acids permeabilize the BBB they gain entrance to the brain where they accumulate in the hypothalamus. In the hypothalamus, bile acids act in a neuroendocrine fashion to reduce the activity of the HPA axis. The dampening effects of bile acids on circulating corticosterone is independent of altering GABAergic tone and the bile acid/neurosteroids receptor TGR5 activation. Bile acids can bind to the glucocorticoid receptor and lead to its nuclear translocation in a similar fashion to glucocorticoids. Hence, there is a possibility that bile acids act as decoy glucocorticoids to activate the glucocorticoid receptor and limit the activity of the HPA axis. These data suggests a novel relationship exists between the body's stress axis and biliary tree. Moreover, bile acids are potentially a molecular link between the liver and the CNS, namely the hypothalamus, and should be viewed now as a neuroendocrine hormone and not merely a detergent.

The Spectrum of Neuroendocrine Neoplasia

The Spectrum of Neuroendocrine Neoplasia Book
Author : Sylvia L. Asa,Stefano La Rosa,Ozgur Mete
Publisher : Springer Nature
Release : 2020-10-19
ISBN : 3030543919
Language : En, Es, Fr & De

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Book Description :

Neuroendocrine neoplasms comprise a large family of proliferative lesions that involve almost every part of the body. Our understanding of their cells of origin as well as the pathology, pathophysiology and genetics of these neoplasms has made tremendous advances in the last few decades. While they are often discussed as separate entities in textbooks of gastroenteropancreatic pathology and pulmonary pathology, their scope is much broader. The book conveys the similarities and differences of these fascinating tumors that may be found from the hypothalamus and pituitary to the rectum, and in soft tissue as well as in many organs. Written by experts in the field, the authors emphasize their structural, functional, predictive and prognostic features and attempt to provide the clinical context that allows improved diagnosis and therapy while building on the genetics that clarifies patterns of inheritance and predisposition to tumor development through precursor lesions. The Spectrum of Neuroendocrine Neoplasia provides a broad overview of neuroendocrine neoplasms using a practical approach to diagnosis, histological classification and therapy, and presents the most important and significant developments of the technologies used to diagnose, classify and treat them.

Neurosecretion and Neuroendocrine Activity

Neurosecretion and Neuroendocrine Activity Book
Author : W. Bargmann,A. Oksche,A. Polenov,B. Scharrer
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 3642668852
Language : En, Es, Fr & De

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Book Description :

This volume on the evolutionary aspects of neuro-endocrinology is based on contributions from the 7th International Symposium on Neurosecretion, which took place in Leningrad, on August 15-21, 1976. The book deals with three major approaches in elucidating the general evolutionary events responsible for the structure and function of neurosecretory elements: (1) phylogenetic development of neurosecretory elements and their function, (2) ontogenetic development of neurosecretory elements and their function, and (3) the role of neuroendocrine mechanisms in realizing species adaptation, i.e., mechanisms causing the evolutionary process. Half of the chapters deal with evolutionary aspects. The majority of them are concerned with the role of different types of neurosecretory cells in the regulation of homeostasis and of the function of endocrine glands, primarily that of the adenohypophysis. The other half are concerned with various aspects of neurosecretion, featuring two main problems: (1) investigation of neural and hormonal mechanisms regulating the function of neurosecretory cells and neurosecretory centers as a whole, and (2) investigation of the role of neurosecretory systems in the regulation of adaptive reactions of the organism.

The Neuroendocrine Immune Network in Ageing

The Neuroendocrine Immune Network in Ageing Book
Author : R.H. Straub,Eugenio Mocchegiani
Publisher : Elsevier
Release : 2004-07-24
ISBN : 9780080479668
Language : En, Es, Fr & De

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Book Description :

The book describes the mechanisms involved in the maintenance of neuroendocrine-immune interactions in ageing. The lack of this maintenance leads to the appearance of age-related diseases (cancer, infections, dementia) and subsequent disability. The capacity of some hormones or nutritional factors in restoring and remodelling the neuroendocrine-immune response during ageing is reported presenting possible new anti-ageing strategies in order to reach healthy ageing and longevity.

The Physiology of Stress

The Physiology of Stress Book
Author : Mary Frances Asterita
Publisher : Unknown
Release : 1985
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download The Physiology of Stress book written by Mary Frances Asterita, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Handbook of Neuroendocrinology

Handbook of Neuroendocrinology Book
Author : Cooper Grant
Publisher : Murphy & Moore Publishing
Release : 2021-11-16
ISBN : 9781639872916
Language : En, Es, Fr & De

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Book Description :

The functional and anatomical interactions between the endocrine system and the nervous system are studied under the field of neuroendocrinology. The neuroendocrine system is responsible for maintaining homeostasis, and managing reproduction, eating and drinking behavior, metabolism, energy utilization, and blood pressure. The advances in neuroendocrinology are essential to the study and management of neurobiological brain disorders. The endocrine system is made up of several glands which are responsible for the production and secretion of different hormones. The hypothalamus is an integral part of the neuroendocrine system. It connects the nervous system to the endocrine system through the pituitary gland. The pituitary gland consists of two portions, the anterior pituitary gland and the posterior pituitary gland. This book unravels the recent studies in the field of neuroendocrinology. It presents researches and studies performed by experts across the globe. Researchers and students in this field will be assisted by this book.

Surgery of the Diencephalon

Surgery of the Diencephalon Book
Author : Robert Holtzman
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 1468455869
Language : En, Es, Fr & De

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Book Description :

The problems of surgical intervention in and about the diencephalic region have stimu lated the interest of neurosurgeons throughout the world. It was therefore not totally surprising when Professor A. N. Konovalov proposed this topic for discussion at the Fifth Annual Stonwin Medical Conference. Bringing the leading figures in this area to New York for a roundtable conference was an exciting challenge. Professor Russel H. Patterson, Jr., generously consented to be our guest of honor. The conference was held at the Winston Estate on July 13-14, 1987, and met our every expectation for a vigorous exchange of individual experiences and more importantly for a dialogue directed toward present and future expectations in the surgery of this region. In addition, the discussions at that small dinner at the Harvard Club of New York led to the creation of an exchange program for neurosurgical residents, fellows, and faculty members of the N. N. Burdenko Neurosurgical Institute, Academy of Medical Science, and the Department of Neurosurgery of the New York Neurological Institute, which was planned for the spring and summer of 1988. The Stonwin Conference and the exchange agreement and program fostered by the Harry Winston Medical Foundation, Inc., represent the fulfillment of goals con ceived by Harry Winston and promulgated by his sons Ronald and Bruce. Henry B. Roberts, Jr.

Neuroendocrine Control of Feeding Behavior

Neuroendocrine Control of Feeding Behavior Book
Author : Serge H. Luquet,Riccarda Granata,Hubert Vaudry
Publisher : Frontiers Media SA
Release : 2019-11-20
ISBN : 2889632024
Language : En, Es, Fr & De

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Book Description :

The hypothalamus plays a crucial role in the regulation of food intake and energy homeostasis. Hypothalamic neuronal circuits thus represent a privileged target for the treatment of eating disorders and metabolic diseases. The present eBook constitutes a unique collection of research articles and reviews that highlight new concepts and recent findings about the neuroendocrine control of feeding behavior.